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Aliases for CHAF1A Gene

Aliases for CHAF1A Gene

  • Chromatin Assembly Factor 1 Subunit A 2 3 5
  • Chromatin Assembly Factor 1, Subunit A (P150) 2 3
  • Chromatin Assembly Factor I P150 Subunit 3 4
  • Chromatin Assembly Factor I (150 KDa) 2 3
  • CAF-I 150 KDa Subunit 3 4
  • CAF-1 Subunit A 3 4
  • CAF-I P150 3 4
  • CAF1P150 3 4
  • Hp150 3 4
  • CTB-50L17.7 3
  • CAF-1 3
  • CAF1B 3
  • P150 3
  • CAF1 3
  • CAF 4

External Ids for CHAF1A Gene

Previous GeneCards Identifiers for CHAF1A Gene

  • GC19P004494
  • GC19P004342
  • GC19P004353
  • GC19P004165

Summaries for CHAF1A Gene

Entrez Gene Summary for CHAF1A Gene

  • Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CHAF1A Gene

CHAF1A (Chromatin Assembly Factor 1 Subunit A) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation. GO annotations related to this gene include identical protein binding and unfolded protein binding.

UniProtKB/Swiss-Prot for CHAF1A Gene

  • Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity).

Gene Wiki entry for CHAF1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHAF1A Gene

Genomics for CHAF1A Gene

Regulatory Elements for CHAF1A Gene

Enhancers for CHAF1A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CHAF1A on UCSC Golden Path with GeneCards custom track

Promoters for CHAF1A Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CHAF1A on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CHAF1A gene promoter:

Genomic Location for CHAF1A Gene

Chromosome:
19
Start:
4,402,612 bp from pter
End:
4,448,308 bp from pter
Size:
45,697 bases
Orientation:
Plus strand

Genomic View for CHAF1A Gene

Genes around CHAF1A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHAF1A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHAF1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHAF1A Gene

Proteins for CHAF1A Gene

  • Protein details for CHAF1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13111-CAF1A_HUMAN
    Recommended name:
    Chromatin assembly factor 1 subunit A
    Protein Accession:
    Q13111
    Secondary Accessions:
    • Q6NXG5
    • Q7Z7K3
    • Q9UJY8

    Protein attributes for CHAF1A Gene

    Size:
    956 amino acids
    Molecular mass:
    106926 Da
    Quaternary structure:
    • Homodimer. Part of the CAF-1 complex that contains RBBP4, CHAF1B and CHAF1A. CHAF1A binds directly to CHAF1B. Only minor amounts of RBBP4 are complexed with CHAF1A and CHAF1B in G1 phase. CHAF1A binds directly to PCNA and to CBX1. Binds MBD1. Interacts directly with CBX5 via the PxVxL motif. During DNA replication, it forms a S phase-specific complex that facilitates DNA methylation and histone H3 Lys-9 methylation during replication-coupled chromatin assembly and is at least composed of the CHAF1A, MBD1 and SETDB1. Interacts with CBX5.
    SequenceCaution:
    • Sequence=AAA76736.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF04291.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH52620.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH52620.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 426.; Evidence={ECO:0000305};

    Alternative splice isoforms for CHAF1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHAF1A Gene

Proteomics data for CHAF1A Gene at MOPED

Post-translational modifications for CHAF1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CHAF1A Gene

No data available for DME Specific Peptides for CHAF1A Gene

Domains & Families for CHAF1A Gene

Protein Domains for CHAF1A Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CHAF1A Gene

Graphical View of Domain Structure for InterPro Entry

Q13111

UniProtKB/Swiss-Prot:

CAF1A_HUMAN :
  • Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
  • Belongs to the CHAF1A family.
Domain:
  • Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain.
Family:
  • Belongs to the CHAF1A family.
genes like me logo Genes that share domains with CHAF1A: view

No data available for Gene Families for CHAF1A Gene

Function for CHAF1A Gene

Molecular function for CHAF1A Gene

UniProtKB/Swiss-Prot Function:
Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity).
genes like me logo Genes that share phenotypes with CHAF1A: view

Animal Models for CHAF1A Gene

MGI Knock Outs for CHAF1A:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CHAF1A Gene

Localization for CHAF1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHAF1A Gene

Nucleus. Note=DNA replication foci.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHAF1A Gene COMPARTMENTS Subcellular localization image for CHAF1A gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for CHAF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IDA --
genes like me logo Genes that share ontologies with CHAF1A: view

Pathways & Interactions for CHAF1A Gene

genes like me logo Genes that share pathways with CHAF1A: view

Pathways by source for CHAF1A Gene

1 Cell Signaling Technology pathway for CHAF1A Gene

Gene Ontology (GO) - Biological Process for CHAF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006281 DNA repair IEA --
genes like me logo Genes that share ontologies with CHAF1A: view

No data available for SIGNOR curated interactions for CHAF1A Gene

Drugs & Compounds for CHAF1A Gene

No Compound Related Data Available

Transcripts for CHAF1A Gene

Unigene Clusters for CHAF1A Gene

Chromatin assembly factor 1, subunit A (p150):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHAF1A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - - -
SP2:
SP3:
SP4: - -
SP5:

Relevant External Links for CHAF1A Gene

GeneLoc Exon Structure for
CHAF1A
ECgene alternative splicing isoforms for
CHAF1A

Expression for CHAF1A Gene

mRNA expression in normal human tissues for CHAF1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CHAF1A Gene

This gene is overexpressed in Adipocyte (44.7) and Testis (14.3).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHAF1A Gene



SOURCE GeneReport for Unigene cluster for CHAF1A Gene Hs.79018

genes like me logo Genes that share expression patterns with CHAF1A: view

Protein tissue co-expression partners for CHAF1A Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CHAF1A Gene

Orthologs for CHAF1A Gene

This gene was present in the common ancestor of animals.

Orthologs for CHAF1A Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHAF1A 35
  • 80.77 (n)
  • 78.42 (a)
CHAF1A 36
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHAF1A 35
  • 83.05 (n)
  • 80.76 (a)
CHAF1A 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chaf1a 35
  • 71.38 (n)
  • 66.06 (a)
Chaf1a 16
Chaf1a 36
  • 68 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHAF1A 35
  • 98.99 (n)
  • 99.16 (a)
CHAF1A 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chaf1a 35
  • 71.79 (n)
  • 66.89 (a)
oppossum
(Monodelphis domestica)
Mammalia CHAF1A 36
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHAF1A 36
  • 34 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHAF1A 35
  • 65.14 (n)
  • 60.05 (a)
CHAF1A 36
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHAF1A 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485264 35
  • 60.98 (n)
  • 59.72 (a)
Str.1170 35
African clawed frog
(Xenopus laevis)
Amphibia LOC398222 35
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5956 35
zebrafish
(Danio rerio)
Actinopterygii chaf1a 36
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Caf1-180 36
  • 19 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea chaf-1 36
  • 26 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1879 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for CHAF1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHAF1A Gene

ENSEMBL:
Gene Tree for CHAF1A (if available)
TreeFam:
Gene Tree for CHAF1A (if available)

Paralogs for CHAF1A Gene

Pseudogenes.org Pseudogenes for CHAF1A Gene

genes like me logo Genes that share paralogs with CHAF1A: view

No data available for Paralogs for CHAF1A Gene

Variants for CHAF1A Gene

Sequence variations from dbSNP and Humsavar for CHAF1A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs35651457 - 4,409,299(+) ACTTG(A/T)CGTTC nc-transcript-variant, reference, missense
rs2230635 - 4,409,514(+) TGCCT(A/G/T)TGGTG nc-transcript-variant, reference, missense
rs8100525 - 4,433,415(+) CCCCA(A/G)AGAGG nc-transcript-variant, reference, missense
rs9352 - 4,442,339(+) TGCTG(C/T)GGGTG nc-transcript-variant, reference, missense
rs243383 - 4,443,002(+) TGACC(A/G/T)CGAGC intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CHAF1A Gene

Variant ID Type Subtype PubMed ID
nsv910817 CNV Loss 21882294
nsv833718 CNV Loss 17160897
nsv910820 CNV Gain 21882294
dgv3674n71 CNV Loss 21882294
nsv910827 CNV Loss 21882294
nsv833720 CNV Loss 17160897
dgv3676n71 CNV Loss 21882294
dgv3677n71 CNV Loss 21882294

Variation tolerance for CHAF1A Gene

Residual Variation Intolerance Score: 16.3% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.96; 59.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CHAF1A Gene

Disorders for CHAF1A Gene

Relevant External Links for CHAF1A

Genetic Association Database (GAD)
CHAF1A
Human Genome Epidemiology (HuGE) Navigator
CHAF1A
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHAF1A

No disorders were found for CHAF1A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHAF1A Gene

Publications for CHAF1A Gene

  1. The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication. (PMID: 7600578) Kaufman P.D. … Stillman B. (Cell 1995) 2 3 4 23 67
  2. The p150 subunit of CAF-1 causes association of SUMO2/3 with the DNA replication foci. (PMID: 19919826) Uwada J. … Saitoh H. (Biochem. Biophys. Res. Commun. 2010) 3 23
  3. Chromatin restoration following nucleotide excision repair involves the incorporation of ubiquitinated H2A at damaged genomic sites. (PMID: 19059499) Zhu Q. … Wani A.A. (DNA Repair (Amst.) 2009) 3 23
  4. Two fundamentally distinct PCNA interaction peptides contribute to chromatin assembly factor 1 function. (PMID: 19822659) Rolef Ben-Shahar T. … Verreault A. (Mol. Cell. Biol. 2009) 3 23
  5. The replication kinase Cdc7-Dbf4 promotes the interaction of the p150 subunit of chromatin assembly factor 1 with proliferating cell nuclear antigen. (PMID: 16826239) GAcrard A. … Almouzni G. (EMBO Rep. 2006) 3 23

Products for CHAF1A Gene

Sources for CHAF1A Gene

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