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CHAF1A Gene

protein-coding   GIFtS: 58
GCID: GC19P004402

Chromatin Assembly Factor 1, Subunit A (P150)

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chromatin Assembly Factor 1, Subunit A (P150)1 2     hp1502 3
Chromatin Assembly Factor I (150 KDa)1 2     CAF-12
Chromatin Assembly Factor I P150 Subunit2 3     CAF12
CAF1P1502 3     CAF1B2
CAF-1 Subunit A2 3     P1502
CAF-I 150 KDa Subunit2 3     Chromatin Assembly Factor 1 Subunit A2
CAF-I P1502 3     CAF3

External Ids:    HGNC: 19101   Entrez Gene: 100362   Ensembl: ENSG000001676707   OMIM: 6012465   UniProtKB: Q131113   

Export aliases for CHAF1A gene to outside databases

Previous GC identifers: GC19P004494 GC19P004342 GC19P004353 GC19P004165


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CHAF1A Gene:
Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150
(CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 (PubMed
7600578)).(supplied by OMIM, Mar 2008)

GeneCards Summary for CHAF1A Gene:
CHAF1A (chromatin assembly factor 1, subunit A (p150)) is a protein-coding gene. GO annotations related to this gene include unfolded protein binding and identical protein binding.

UniProtKB/Swiss-Prot: CAF1A_HUMAN, Q13111
Function: Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication
and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the
nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B
can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds
to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly
synthesized cbx proteins to heterochromatic DNA replication foci (By similarity). Also involved in vitamin
D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex
recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the
CYP27B1 gene

Gene Wiki entry for CHAF1A Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NC_018930.2  NT_011295.12  
Regulatory elements:
   Regulatory transcription factor binding sites in the CHAF1A gene promoter:
         c-Fos   AP-1   AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCHAF1A promoter sequence
   Search Chromatin IP Primers for CHAF1A

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CHAF1A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19p13.3   Ensembl cytogenetic band:  19p13.3   HGNC cytogenetic band: 19p13.3

CHAF1A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CHAF1A gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P004402:  view genomic region     (about GC identifiers)

Start:
4,402,659 bp from pter      End:
4,445,015 bp from pter
Size:
42,357 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CAF1A_HUMAN, Q13111 (See protein sequence)
Recommended Name: Chromatin assembly factor 1 subunit A  
Size: 956 amino acids; 106926 Da
Subunit: Homodimer. Part of the CAF-1 complex that contains RBBP4, CHAF1B and CHAF1A. CHAF1A binds directly to
CHAF1B. Only minor amounts of RBBP4 are complexed with CHAF1A and CHAF1B in G1 phase. CHAF1A binds directly to
PCNA and to CBX1. Binds MBD1. Interacts directly with CBX5 via the PxVxL motif. During DNA replication, it forms
a S phase-specific complex that facilitates DNA methylation and histone H3 'Lys-9' methylation during
replication-coupled chromatin assembly and is at least composed of the CHAF1A, MBD1 and SETDB1. Component of the
WINAC complex, at least composed of SMARCA2, SMARCA4, SMARCB1, SMARCC1, SMARCC2, SMARCD1, SMARCE1, ACTL6A,
BAZ1B/WSTF, ARID1A, SUPT16H, CHAF1A and TOP2B. Interacts with CBX5
Developmental stage: Active complex is found in G1, S and G2 phases
Sequence caution: Sequence=AAA76736.1; Type=Erroneous initiation; Sequence=AAF04291.1; Type=Erroneous initiation;
Sequence=AAH52620.1; Type=Erroneous initiation; Note=Translation N-terminally extended; Sequence=AAH52620.1;
Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 426;
Secondary accessions: Q6NXG5 Q7Z7K3 Q9UJY8
Alternative splicing: 3 isoforms:  Q13111-1   Q13111-2   Q13111-3   

Explore the universe of human proteins at neXtProt for CHAF1A: NX_Q13111

Explore proteomics data for CHAF1A at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CHAF1A Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005474.2  
    ENSEMBL proteins: 
     ENSP00000301280   ENSP00000465142   ENSP00000467296   ENSP00000466888   ENSP00000466475  

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR022043 CAF1A

    Graphical View of Domain Structure for InterPro Entry Q13111

    ProtoNet protein and cluster: Q13111

    UniProtKB/Swiss-Prot: CAF1A_HUMAN, Q13111
    Domain: Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow
    domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the
    chromoshadow domain
    Similarity: Belongs to the CHAF1A family


    Find genes that share domains with CHAF1A           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CAF1A_HUMAN, Q13111
    Function: Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication
    and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the
    nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B
    can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds
    to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly
    synthesized cbx proteins to heterochromatic DNA replication foci (By similarity). Also involved in vitamin
    D-coupled transcription regulation via its association with the WINAC complex, a chromatin-remodeling complex
    recruited by vitamin D receptor (VDR), which is required for the ligand-bound VDR-mediated transrepression of the
    CYP27B1 gene

         Gene Ontology (GO): 5 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003682chromatin binding TAS7600578
    GO:0005515protein binding IPI15805117
    GO:0042802identical protein binding IPI16826239
    GO:0051082unfolded protein binding TAS7600578
    GO:0070087chromo shadow domain binding IPI15882967
         
    Find genes that share ontologies with CHAF1A           About GenesLikeMe


    Phenotypes:
         6 GenomeRNAi human phenotypes for CHAF1A:
     Decreased G3BP1 protein expres  Increased HPV18 LCR reporter a  Increased S DNA content, incre  Increased cell number in S and 
     S arrest  Synthetic lethal with Ras 

         3 MGI mutant phenotypes (inferred from 1 allele(MGI details for Chaf1a):
     cellular  embryogenesis  mortality/aging 

    Find genes that share phenotypes with CHAF1A           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Chaf1atm1Ger for CHAF1A

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    miRTarBase miRNAs that target CHAF1A:
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    Block miRNA regulation of human, mouse, rat CHAF1A using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CHAF1A (see all 27):
    hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-302e hsa-miR-1297 hsa-miR-520a-3p hsa-miR-372 hsa-miR-93
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CAF1A_HUMAN, Q13111: Nucleus. Note=DNA replication foci
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    cytosol1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0033186CAF-1 complex IDA8858152
    GO:0071778WINAC complex IDA--

    Find genes that share ontologies with CHAF1A           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CHAF1A About    
    See pathways by source

    SuperPathContained pathways About
    1Chromatin Regulation / Acetylation
    Chromatin Regulation / Acetylation


    Find genes that share SuperPaths with CHAF1A           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Cell Signaling Technology (CST) Pathway for CHAF1A
        Chromatin Regulation / Acetylation


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CHAF1A
    Interactions:

        GeneGlobe Interaction Network for CHAF1A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CHAF1A (Q131111, 2, 3 ENSP000003012804) via UniProtKB, MINT, STRING, and/or I2D (see all 141)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H3CP684312, 3MINT-7221140 MINT-7221095 MINT-7220359 I2D: score=6 
    HIST1H3DP684312, 3MINT-7221140 MINT-7221095 MINT-7220359 I2D: score=6 
    HIST1H3FP684312, 3MINT-7221140 MINT-7221095 MINT-7220359 I2D: score=6 
    HIST1H3GP684312, 3MINT-7221140 MINT-7221095 MINT-7220359 I2D: score=6 
    HIST1H3IP684312, 3MINT-7221140 MINT-7221095 MINT-7220359 I2D: score=6 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006260DNA replication IEA--
    GO:0006281DNA repair IEA--
    GO:0006335DNA replication-dependent nucleosome assembly TAS7600578
    GO:0006351transcription, DNA-templated IEA--
    GO:0006355regulation of transcription, DNA-templated IEA--

    Find genes that share ontologies with CHAF1A           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
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      Browse compounds at ApexBio 

    Browse Tocris compounds for CHAF1A (CAF1A)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CHAF1A gene: 
    NM_005483.2  

    Unigene Cluster for CHAF1A:

    Chromatin assembly factor 1, subunit A (p150)
    Hs.79018  [show with all ESTs]
    Unigene Representative Sequence: NM_005483
    7 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000301280(uc002mal.3) ENST00000587580 ENST00000585854 ENST00000587739
    ENST00000585371 ENST00000587368 ENST00000589648
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    hsa-miR-302d hsa-miR-520e hsa-miR-106a hsa-miR-302e hsa-miR-1297 hsa-miR-520a-3p hsa-miR-372 hsa-miR-93
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    Additional mRNA sequence: 

    BC005813.2 BC011560.1 BC041606.1 BC052620.1 BC067093.1 U20979.1 

    11 DOTS entries:

    DT.451772  DT.75189320  DT.434268  DT.121498113  DT.100780596  DT.75189324  DT.100780601  DT.86855262 
    DT.92429446  DT.92429450  DT.95198998 

    Selected AceView cDNA sequences (see all 238):

    BM676380 BM465304 AW015784 BM824075 BU931789 BM971109 BQ651348 NM_005483 
    BU943473 BU152683 BQ652141 BC052620 BE504627 BC041606 BC067093 BM917102 
    AI217058 BC011560 BQ644096 BQ648579 BM927772 AI191348 AI494528 Z43197 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CHAF1A    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
    SP1:                    -                                         -                                               -                           
    SP2:                                                                                                                                          
    SP3:                                                                                                                                          
    SP4:              -     -                                                                                                                     
    SP5:                                                                                                                                          


    ECgene alternative splicing isoforms for CHAF1A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CHAF1A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CHAF1A Expression
    About this image


    CHAF1A expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Ovary (Reproductive System)
             Oviduct
     
     Bone (Muscoskeletal System)
             Bone Marrow
    CHAF1A Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CHAF1A Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.79018
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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals.

    Orthologs for CHAF1A gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Chaf1a1 , 5 chromatin assembly factor 1, subunit A (p150)1, 5 71.38(n)1
    66.06(a)1
      17 (29.13 cM)5
    272211  NM_013733.31  NP_038761.11 
     560404165 
    chicken
    (Gallus gallus)
    Aves CHAF1A1 chromatin assembly factor 1, subunit A (p150) 65.14(n)
    60.05(a)
      770217  NM_001079752.2  NP_001073220.2 
    lizard
    (Anolis carolinensis)
    Reptilia CHAF1A6
    chromatin assembly factor 1, subunit A (p150)
    54(a)
    1 ↔ 1
    GL343757.1(191971-207622)
    African clawed frog
    (Xenopus laevis)
    Amphibia LOC3982222 chromatin assembly factor 1 p150 subunit 76.53(n)    AF222339.1 
    zebrafish
    (Danio rerio)
    Actinopterygii chaf1a6
    chromatin assembly factor 1, subunit A (p150)
    45(a)
    1 ↔ 1
    22(22639669-22665315) ENSDARG00000062152
    fruit fly
    (Drosophila melanogaster)
    Insecta Caf1-1806
    Caf1-180
    19(a)
    1 ↔ 1
    X(8496394-8500335)
    worm
    (Caenorhabditis elegans)
    Secernentea chaf-16
    Protein CHAF-1 (chaf-1) mRNA, complete cds
    26(a)
    1 ↔ 1
    I(9077566-9080024) WBGene00011532


    ENSEMBL Gene Tree for CHAF1A (if available)
    TreeFam Gene Tree for CHAF1A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CHAF1A gene

    Find genes that share paralogs with CHAF1A           About GenesLikeMe


    1 Pseudogenes.org Pseudogene for CHAF1A
    PGOHUM00000236323


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CHAF1A (see all 1058)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs2006771911,2
    --4402659(+) CCGCG-/GCG   
      GCAGCA
    GCGGC
    1 -- cds10--------
    rs777345481,2
    C--4402840(+) GGAAGG/AGGGGG 1 -- int13Minor allele frequency- A:0.27WA EA 240
    rs1714741,2
    C,F,A--4402936(+) TTCACC/ACCCTG 1 -- int19Minor allele frequency- A:0.43MN NA CSA WA EA 611
    rs1179981881,2
    F--4403007(+) GTTGTA/GGCCGC 1 -- int11Minor allele frequency- G:0.01EA 120
    rs2433381,2
    C,F,A,H--4403017(+) CGACCA/GTATTG 1 -- int126Minor allele frequency- G:0.41MN NS EA NA CSA WA 2955
    rs729887231,2
    --4403063(+) CAGGAC/TTCTCT 1 -- int10--------
    rs1815341751,2
    --4403088(+) GAGGGA/GCCGAG 1 -- int10--------
    rs1119808121,2
    C,F--4403169(+) ACCATG/ATTGGA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1397507551,2
    --4403246(+) TGAGGA/GTCGGG 1 -- int10--------
    rs2433391,2
    C,F,O--4403261(+) GCCCGA/GGTAAG 1 -- int112Minor allele frequency- N:0.00EA NA WA CSA 581

    HapMap Linkage Disequilibrium report for CHAF1A (4402659 - 4445015 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CHAF1A:    About this table    
    Variant IDTypeSubtypePubMed ID
    dgv3677n71CNV Loss21882294
    nsv910827CNV Loss21882294
    dgv3674n71CNV Loss21882294
    dgv3676n71CNV Loss21882294
    nsv833718CNV Loss17160897
    nsv910817CNV Loss21882294
    nsv833720CNV Loss17160897
    nsv910820CNV Gain21882294

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CHAF1A
    DNA2.0 Custom Variant and Variant Library Synthesis for CHAF1A

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601246    OMIM disorders: --

    1 disease from the University of Copenhagen DISEASES database for CHAF1A:
    Cornelia de Lange syndrome

    Find genes that share disorders with CHAF1A           About GenesLikeMe

    Genetic Association Database (GAD): CHAF1A
    Human Genome Epidemiology (HuGE) Navigator: CHAF1A (4 documents)

    Export disorders for CHAF1A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CHAF1A gene, integrated from 10 sources (see all 122):
    (articles sorted by number of sources associating them with CHAF1A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication. (PubMed id 7600578)1, 2, 3, 9 Kaufman P.D.... Stillman B. (Cell 1995)
    2. Dimerization of the largest subunit of chromatin assembly factor 1: importance in vitro and during Xenopus early development. (PubMed id 11296234)1, 2, 9 Quivy J.-P.... Almouzni G. (EMBO J. 2001)
    3. Genomic sequence and expression analyses of human chromatin assembly factor 1 p150 gene. (PubMed id 11250073)1, 2, 9 Dong H.... Huang G.M. (Gene 2001)
    4. CAF-1 and the inheritance of chromatin states: at the crossroads of DNA replication and repair. (PubMed id 10893180)1, 2, 9 Ridgway P. and Almouzni G. (J. Cell Sci. 2000)
    5. Replication-dependent marking of DNA by PCNA facilitates CAF-1- coupled inheritance of chromatin. (PubMed id 10052459)1, 2, 9 Shibahara K. and Stillman B. (Cell 1999)
    6. A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage. (PubMed id 10648606)1, 2, 9 Moggs J.G.... Almouzni G. (Mol. Cell. Biol. 2000)
    7. Human POGZ modulates dissociation of HP1alpha from mitotic chromosome arms through Aurora B activation. (PubMed id 20562864)1, 2 Nozawa R.S.... Obuse C. (Nat. Cell Biol. 2010)
    8. Investigation of genetic susceptibility factors for human longevity - a targeted nonsynonymous SNP study. (PubMed id 20800603)1, 4 Flachsbart F....Nebel A. (Mutat. Res. 2010)
    9. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    10. The mammalian heterochromatin protein 1 binds diverse nuclear proteins through a common motif that targets the chromoshadow domain. (PubMed id 15882967)1, 2 Lechner M.S.... Rauscher F.J. III (Biochem. Biophys. Res. Commun. 2005)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10036 HGNC: 1910 AceView: CHAF1A Ensembl:ENSG00000167670 euGenes: HUgn10036
    ECgene: CHAF1A H-InvDB: CHAF1A

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CHAF1A Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CHAF1A Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CHAF1A gene:
    Search GeneIP for patents involving CHAF1A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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