Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CHAF1A Gene

Aliases for CHAF1A Gene

  • Chromatin Assembly Factor 1, Subunit A (P150) 2 3
  • Chromatin Assembly Factor I P150 Subunit 3 4
  • Chromatin Assembly Factor I (150 KDa) 2 3
  • CAF-I 150 KDa Subunit 3 4
  • CAF-1 Subunit A 3 4
  • CAF-I P150 3 4
  • CAF1P150 3 4
  • Hp150 3 4
  • Chromatin Assembly Factor 1 Subunit A 3
  • CTB-50L17.7 3
  • Caf1b 3
  • CAF-1 3
  • P150 3
  • CAF1 3
  • CAF 4

External Ids for CHAF1A Gene

Summaries for CHAF1A Gene

Entrez Gene Summary for CHAF1A Gene

  • Chromatin assembly factor I (CAF1) is a nuclear complex consisting of p50, p60 (CHAF1B; MIM 601245), and p150 (CHAF1A) subunits that assembles histone octamers onto replicating DNA in vitro (Kaufman et al., 1995 [PubMed 7600578]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CHAF1A Gene

CHAF1A (Chromatin Assembly Factor 1, Subunit A (P150)) is a Protein Coding gene. Among its related pathways are Chromatin Regulation / Acetylation. GO annotations related to this gene include identical protein binding and unfolded protein binding.

UniProtKB/Swiss-Prot for CHAF1A Gene

  • Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity).

Gene Wiki entry for CHAF1A Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHAF1A Gene

Genomics for CHAF1A Gene

Genomic Location for CHAF1A Gene

Start:
4,402,662 bp from pter
End:
4,445,018 bp from pter
Size:
42,357 bases
Orientation:
Plus strand

Genomic View for CHAF1A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHAF1A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHAF1A Gene

Regulatory Elements for CHAF1A Gene

Transcription factor binding sites by QIAGEN in the CHAF1A gene promoter:

Proteins for CHAF1A Gene

  • Protein details for CHAF1A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q13111-CAF1A_HUMAN
    Recommended name:
    Chromatin assembly factor 1 subunit A
    Protein Accession:
    Q13111
    Secondary Accessions:
    • Q6NXG5
    • Q7Z7K3
    • Q9UJY8

    Protein attributes for CHAF1A Gene

    Size:
    956 amino acids
    Molecular mass:
    106926 Da
    Quaternary structure:
    • Homodimer. Part of the CAF-1 complex that contains RBBP4, CHAF1B and CHAF1A. CHAF1A binds directly to CHAF1B. Only minor amounts of RBBP4 are complexed with CHAF1A and CHAF1B in G1 phase. CHAF1A binds directly to PCNA and to CBX1. Binds MBD1. Interacts directly with CBX5 via the PxVxL motif. During DNA replication, it forms a S phase-specific complex that facilitates DNA methylation and histone H3 Lys-9 methylation during replication-coupled chromatin assembly and is at least composed of the CHAF1A, MBD1 and SETDB1. Interacts with CBX5.
    SequenceCaution:
    • Sequence=AAA76736.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAF04291.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=AAH52620.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAH52620.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence starting in position 426.; Evidence={ECO:0000305};

    Alternative splice isoforms for CHAF1A Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHAF1A Gene

Proteomics data for CHAF1A Gene at MOPED

Post-translational modifications for CHAF1A Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CHAF1A Gene

No data available for DME Specific Peptides for CHAF1A Gene

Domains for CHAF1A Gene

Protein Domains for CHAF1A Gene

InterPro:
ProtoNet:

UniProtKB/Swiss-Prot:

CAF1A_HUMAN
Domain:
  • Contains one Pro-Xaa-Val-Xaa-Leu (PxVxL) motif, which is required for interaction with chromoshadow domains. This motif requires additional residues -7, -6, +4 and +5 of the central Val which contact the chromoshadow domain:
    • Q13111
Family:
  • Belongs to the CHAF1A family.:
    • Q13111
genes like me logo Genes that share domains with CHAF1A: view

No data available for Gene Families for CHAF1A Gene

Function for CHAF1A Gene

Molecular function for CHAF1A Gene

UniProtKB/Swiss-Prot Function: Core component of the CAF-1 complex, a complex thought to mediate chromatin assembly in DNA replication and DNA repair. Assembles histone octamers onto replicating DNA in vitro. CAF-1 performs the first step of the nucleosome assembly process, bringing newly synthesized histones H3 and H4 to replicating DNA; histones H2A/H2B can bind to this chromatin precursor subsequent to DNA replication to complete the histone octamer. CHAF1A binds to histones H3 and H4. It may play a role in heterochromatin maintenance in proliferating cells by bringing newly synthesized cbx proteins to heterochromatic DNA replication foci (By similarity).

Gene Ontology (GO) - Molecular Function for CHAF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003682 chromatin binding TAS 7600578
GO:0005515 protein binding IPI 15805117
GO:0042802 identical protein binding IPI 16826239
GO:0051082 unfolded protein binding TAS 7600578
GO:0070087 chromo shadow domain binding IPI 15882967
genes like me logo Genes that share ontologies with CHAF1A: view
genes like me logo Genes that share phenotypes with CHAF1A: view

Animal Models for CHAF1A Gene

MGI Knock Outs for CHAF1A:

miRNA for CHAF1A Gene

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CHAF1A Gene

Localization for CHAF1A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHAF1A Gene

Nucleus. Note=DNA replication foci.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHAF1A Gene COMPARTMENTS Subcellular localization image for CHAF1A gene
Compartment Confidence
nucleus 5
cytosol 1

Gene Ontology (GO) - Cellular Components for CHAF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000790 nuclear chromatin IDA 14718166
GO:0033186 CAF-1 complex IDA 8858152
GO:0043234 protein complex IDA 14718166
genes like me logo Genes that share ontologies with CHAF1A: view

Pathways for CHAF1A Gene

genes like me logo Genes that share pathways with CHAF1A: view

Pathways by source for CHAF1A Gene

1 Cell Signaling Technology pathway for CHAF1A Gene

Gene Ontology (GO) - Biological Process for CHAF1A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006260 DNA replication IEA --
GO:0006281 DNA repair IEA --
GO:0006335 DNA replication-dependent nucleosome assembly IDA 14718166
GO:0006351 transcription, DNA-templated --
GO:0006355 regulation of transcription, DNA-templated --
genes like me logo Genes that share ontologies with CHAF1A: view

Transcripts for CHAF1A Gene

Unigene Clusters for CHAF1A Gene

Chromatin assembly factor 1, subunit A (p150):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHAF1A Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d ^ 4 ^ 5a · 5b ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14a · 14b ^ 15
SP1: - - -
SP2:
SP3:
SP4: - -
SP5:

Relevant External Links for CHAF1A Gene

GeneLoc Exon Structure for
CHAF1A
ECgene alternative splicing isoforms for
CHAF1A

Expression for CHAF1A Gene

mRNA expression in normal human tissues for CHAF1A Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHAF1A Gene

SOURCE GeneReport for Unigene cluster for CHAF1A Gene Hs.79018

genes like me logo Genes that share expressions with CHAF1A: view

Orthologs for CHAF1A Gene

This gene was present in the common ancestor of animals.

Orthologs for CHAF1A Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHAF1A 36
  • 98.99 (n)
  • 99.16 (a)
CHAF1A 37
  • 99 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CHAF1A 36
  • 80.77 (n)
  • 78.42 (a)
CHAF1A 37
  • 77 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHAF1A 36
  • 83.05 (n)
  • 80.76 (a)
CHAF1A 37
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chaf1a 36
  • 71.38 (n)
  • 66.06 (a)
Chaf1a 16
Chaf1a 37
  • 68 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHAF1A 37
  • 62 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHAF1A 37
  • 34 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chaf1a 36
  • 71.79 (n)
  • 66.89 (a)
chicken
(Gallus gallus)
Aves CHAF1A 36
  • 65.14 (n)
  • 60.05 (a)
CHAF1A 37
  • 58 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHAF1A 37
  • 54 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia LOC398222 36
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100485264 36
  • 60.98 (n)
  • 59.72 (a)
Str.1170 36
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.5956 36
zebrafish
(Danio rerio)
Actinopterygii chaf1a 37
  • 45 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta Caf1-180 37
  • 19 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea chaf-1 37
  • 26 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1879 36
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 42 (a)
OneToOne
Species with no ortholog for CHAF1A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CHAF1A Gene

ENSEMBL:
Gene Tree for CHAF1A (if available)
TreeFam:
Gene Tree for CHAF1A (if available)

Paralogs for CHAF1A Gene

Pseudogenes.org Pseudogenes for CHAF1A Gene

genes like me logo Genes that share paralogs with CHAF1A: view

No data available for Paralogs for CHAF1A Gene

Variants for CHAF1A Gene

Sequence variations from dbSNP and Humsavar for CHAF1A Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2992 -- 4,443,049(-) TAAGC(A/G)TTCTA utr-variant-3-prime
rs9352 - 4,442,339(+) TGCTG(C/T)GGGTG reference, missense
rs105037 -- 4,414,597(+) ACTCA(A/G)GGGTG intron-variant
rs105038 -- 4,414,713(+) TTCTG(C/T)TGTTT intron-variant
rs171474 -- 4,402,939(+) TTCAC(A/C)CCCTG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHAF1A Gene

Variant ID Type Subtype PubMed ID
nsv910817 CNV Loss 21882294
nsv833718 CNV Loss 17160897
nsv910820 CNV Gain 21882294
dgv3674n71 CNV Loss 21882294
nsv910827 CNV Loss 21882294
nsv833720 CNV Loss 17160897
dgv3676n71 CNV Loss 21882294
dgv3677n71 CNV Loss 21882294

Relevant External Links for CHAF1A Gene

HapMap Linkage Disequilibrium report
CHAF1A

Disorders for CHAF1A Gene

(1) University of Copenhagen DISEASES for CHAF1A Gene

Relevant External Links for CHAF1A

Genetic Association Database (GAD)
CHAF1A
Human Genome Epidemiology (HuGE) Navigator
CHAF1A
genes like me logo Genes that share disorders with CHAF1A: view

No data available for UniProtKB/Swiss-Prot for CHAF1A Gene

Publications for CHAF1A Gene

  1. The p150 and p60 subunits of chromatin assembly factor I: a molecular link between newly synthesized histones and DNA replication. (PMID: 7600578) Kaufman P.D. … Stillman B. (Cell 1995) 2 3 4 23
  2. Replication-dependent marking of DNA by PCNA facilitates CAF-1- coupled inheritance of chromatin. (PMID: 10052459) Shibahara K. … Stillman B. (Cell 1999) 3 4 23
  3. A CAF-1-PCNA-mediated chromatin assembly pathway triggered by sensing DNA damage. (PMID: 10648606) Moggs J.G. … Almouzni G. (Mol. Cell. Biol. 2000) 3 4 23
  4. CAF-1 and the inheritance of chromatin states: at the crossroads of DNA replication and repair. (PMID: 10893180) Ridgway P. … Almouzni G. (J. Cell Sci. 2000) 3 4 23
  5. Genomic sequence and expression analyses of human chromatin assembly factor 1 p150 gene. (PMID: 11250073) Dong H. … Huang G.M. (Gene 2001) 3 4 23

Products for CHAF1A Gene

Sources for CHAF1A Gene

Back to Top

Content