CHADL Gene
protein-coding GIFtS: 39
GCID: GC22M041625
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chondroadherin-like
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Aliases
for CHADL gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chondroadherin-Like1 | | SLRR4B1 2 3 | | Chondroadherin-Like Protein2 |
| External Ids: | HGNC: 251651 | Entrez Gene: 1503562 | Ensembl: ENSG000001003997 | UniProtKB: Q6NUI63 |
Export aliases for CHADL gene to outside databasesPrevious GC identifers: GC22U900391 GC22M039955 GC22M024589
|---|
Summaries
for CHADL gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CHADL gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000022.10 NC_018933.1 NT_011520.12
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CHADL gene promoter:
Pax-5 Brachyury Olf-1 AP-4 LCR-F1 C/EBPalpha E47 CREB Max c-Myc
Other transcription factors
Search SABiosciences Chromatin IP Primers for CHADL
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHADL |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 22q13.2 Ensembl cytogenetic band: 22q13.2 HGNC cytogenetic band: 22q13.2CHADL Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 22 GeneLoc Exon Structure GeneLoc location for GC22M041625: view genomic region
(about GC identifiers)
Start:
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41,625,514 bp from pter |
End:
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41,636,938 bp from pter |
Size:
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11,425 bases |
Orientation:
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minus strand |
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Proteins
for CHADL gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CHADL_HUMAN, Q6NUI6 (See
protein sequence)Recommended Name: Chondroadherin-like protein precursor Size: 762 amino acids; 82388 Da
Subcellular location: Secreted, extracellular space, extracellular matrix (By similarity)
Sequence caution: Sequence=AAH19839.1; Type=Frameshift; Positions=504; Sequence=AAH68590.1; Type=Erroneous initiation;
Secondary accessions: Q05CY2 Q4G0S0 Q5JY13 Q86XY1 Q96E60Alternative splicing: 2 isoforms: Q6NUI6-1 Q6NUI6-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CHADL: NX_Q6NUI6
CHADL Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_612490.1
ENSEMBL proteins: ENSP00000392046 ENSP00000216241 ENSP00000412359
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005578 | proteinaceous extracellular matrix |
IEA | -- | | GO:0031012 | colocalizes with extracellular matrix |
ISS | -- |
CHADL for ontologies About GeneDecksing
CHADL Antibody Products:
Assay Products for CHADL: |
Protein
Domains /
Families
for CHADL gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CHADL for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q6NUI6ProtoNet protein and cluster: Q6NUI6 3 Blocks protein families: IPB000372 Cysteine-rich flanking region IPB000483 Cysteine-rich flanking region IPB001611 Leucine-rich repeat signature
UniProtKB/Swiss-Prot: CHADL_HUMAN, Q6NUI6Similarity: Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamilySimilarity: Contains 19 LRR (leucine-rich) repeatsSimilarity: Contains 2 LRRCT domainsSimilarity: Contains 2 LRRNT domains |
Function
for CHADL gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHADL (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHADL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CHADL (NM_138481) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHADL | |  | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CHADL |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHADL |
|
Pathways & Interactions
for CHADL gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHADL
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
2 Interacting proteins for CHADL (ENSP000002162414) via UniProtKB, MINT, STRING, and/or I2DAbout this table
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Drugs & Compounds
for CHADL gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CHADL
Search CenterWatch for drugs/clinical trials and news about CHADL
|
Transcripts
for CHADL gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CHADL gene: NM_138481.1 Unigene Cluster for CHADL: Chondroadherin-like Hs.344488 [show with all ESTs]Unigene Representative Sequence: BC0685903 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000417999 ENST00000216241(uc003azq.4 uc010gyj.3) ENST00000455425
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHADL (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHADL
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CHADL (NM_138481) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHADL | | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CHADL |
Additional cDNA sequence: BC012882.1 BC019839.1 BC040188.1 BC048421.1 BC068590.1 3 DOTS entries: DT.91659395 DT.120647809 DT.40115125 24/323 AceView cDNA sequences (see all 323): CR615880 BM810912 CR456557 BU190935 BQ685176 CR599804 AA974279 BU194287 BU191873 BQ061240 H55068 BP430397 BQ682655 BQ431750 CF126041 BE729240 BQ687185 BU172655 BM553409 AI648516 BM542955 BQ772731 BQ217588 AA709404
GeneLoc Exon Structure
3 Alternative Splicing Database (ASD) splice patterns (SP) for CHADL About this scheme
| ExUns: | 1a | · | 1b | · | 1c | ^ | 2 | ^ | 3 | ^ | 4a | · | 4b | ^ | 5 | ^ | 6a | · | 6b |
|---|
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| SP1: | | | | | | | - | | - | | - | | | | | | | | | | |
| SP2: | | | | | - | | | | | | | | | | | | | | | | |
| SP3: | | | | | | | | | | | | | | | | | | | | |
ECgene alternative splicing isoforms for CHADL
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Expression
for CHADL gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CHADL expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GCCTTCCAGG
About this image
See CHADL Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHADL
SOURCE GeneReport for Unigene cluster: Hs.344488
SABiosciences Custom PCR Arrays for CHADL
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHADL
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHADL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHADL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHADL | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHADL |
Orthologs
for CHADL gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CHADL gene from 5/16 species (see all 16) About this table
ENSEMBL Gene Tree for CHADL (if available)
TreeFam Gene Tree for CHADL (if available) |
Paralogs
for CHADL gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CHADL gene
- FLRT12 GP52 CPN22 LRIG32 LRRTM42 CHAD2 FLRT32 LRRC152
- LRIG22 LRRTM32 IGFALS2 LRIG12 LRRTM22 FLRT22 VASN2 LRRTM12
4 SIMAP similar genes for CHADL using alignment to 3 protein entries: CHADL_HUMAN (see all proteins):CHAD ISLR RTN4RL2 SLIT2
CHADL for paralogs About GeneDecksing
|
Genomic Variants
for CHADL gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 22 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CHADL (41625514 - 41636938 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CHADL: -- | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHADL |
|
Disorders
/ Diseases
for CHADL gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CHADL gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CHADL gene integrated from 9 sources:
(articles sorted by number of sources associating them with CHADL) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1, 3 Strausberg R.L....Marra M.A. (2002)
- Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (2008)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- The DNA sequence of human chromosome 22. (PubMed id 10591208)2 Dunham I....O'Brien K.P. (1999)
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External Searches for CHADL gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CHADL gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CHADL gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CHADL gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CHADL | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CHADL gene:
Search GeneIP for patents involving CHADL
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CHADL gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CHADL | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHADL | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHADL | | | Browse OriGene Protein Over-expression Lysates | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CHADL | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHADL | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHADL | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CHADL | | OriGene Custom Protein Services for CHADL | | | OriGene Custom Immunoassay Development | | |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHADL | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHADL | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHADL | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHADL | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHADL | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHADL |
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 |  |  |  | |
| | | | Search Tocris compounds for CHADL |
| |  |  |  |  | | | | |
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 |
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 | | | CHADL Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHADL |
|  |  |  | | | | Search ThermoFisher Antibodies for CHADL |
| | | Search Vector BioLabs for ready-to-use adenovirus/AAV for human, mouse, rat CHADL |
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