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Aliases for CHADL Gene

Aliases for CHADL Gene

  • Chondroadherin Like 2 3 5
  • Chondroadherin-Like 2 3
  • SLRR4B 3 4

External Ids for CHADL Gene

Previous GeneCards Identifiers for CHADL Gene

  • GC22U900391
  • GC22M039955
  • GC22M041625
  • GC22M024589

Summaries for CHADL Gene

GeneCards Summary for CHADL Gene

CHADL (Chondroadherin Like) is a Protein Coding gene. GO annotations related to this gene include collagen binding and collagen fibril binding. An important paralog of this gene is LRRTM2.

UniProtKB/Swiss-Prot for CHADL Gene

  • Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocytes differentiation by acting on its cellular collagenous microenvironment.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHADL Gene

Genomics for CHADL Gene

Regulatory Elements for CHADL Gene

Promoters for CHADL Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CHADL on UCSC Golden Path with GeneCards custom track

Genomic Location for CHADL Gene

Chromosome:
22
Start:
41,209,869 bp from pter
End:
41,241,762 bp from pter
Size:
31,894 bases
Orientation:
Minus strand

Genomic View for CHADL Gene

Genes around CHADL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHADL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHADL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHADL Gene

Proteins for CHADL Gene

  • Protein details for CHADL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NUI6-CHADL_HUMAN
    Recommended name:
    Chondroadherin-like protein
    Protein Accession:
    Q6NUI6
    Secondary Accessions:
    • Q05CY2
    • Q4G0S0
    • Q5JY13
    • Q86XY1
    • Q96E60

    Protein attributes for CHADL Gene

    Size:
    762 amino acids
    Molecular mass:
    82388 Da
    Quaternary structure:
    • Associates with collagen and binds to collagen fibrils.
    SequenceCaution:
    • Sequence=AAH19839.1; Type=Frameshift; Positions=504; Evidence={ECO:0000305}; Sequence=AAH68590.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CHADL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHADL Gene

Proteomics data for CHADL Gene at MOPED

Post-translational modifications for CHADL Gene

  • Glycosylation at Asn 52 and Asn 626
  • Modification sites at PhosphoSitePlus

Other Protein References for CHADL Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHADL Gene

Domains & Families for CHADL Gene

Suggested Antigen Peptide Sequences for CHADL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NUI6

UniProtKB/Swiss-Prot:

CHADL_HUMAN :
  • Contains 2 LRRCT domains.
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.
  • Contains 19 LRR (leucine-rich) repeats.
Domain:
  • Contains 2 LRRCT domains.
  • Contains 2 LRRNT domains.
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.
Similarity:
  • Contains 19 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with CHADL: view

No data available for Gene Families for CHADL Gene

Function for CHADL Gene

Molecular function for CHADL Gene

UniProtKB/Swiss-Prot Function:
Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocytes differentiation by acting on its cellular collagenous microenvironment.

Phenotypes for CHADL Gene

GenomeRNAi human phenotypes for CHADL:
genes like me logo Genes that share phenotypes with CHADL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CHADL

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CHADL Gene

Localization for CHADL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHADL Gene

Secreted. Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHADL Gene COMPARTMENTS Subcellular localization image for CHADL gene
Compartment Confidence
extracellular 4
mitochondrion 3
golgi apparatus 1
lysosome 1
peroxisome 1
vacuole 1

No data available for Gene Ontology (GO) - Cellular Components for CHADL Gene

Pathways & Interactions for CHADL Gene

SuperPathways for CHADL Gene

No Data Available

Interacting Proteins for CHADL Gene

Gene Ontology (GO) - Biological Process for CHADL Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CHADL Gene

Drugs & Compounds for CHADL Gene

No Compound Related Data Available

Transcripts for CHADL Gene

Unigene Clusters for CHADL Gene

Chondroadherin-like:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHADL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - -
SP2: -
SP3:

Relevant External Links for CHADL Gene

GeneLoc Exon Structure for
CHADL
ECgene alternative splicing isoforms for
CHADL

Expression for CHADL Gene

mRNA expression in normal human tissues for CHADL Gene

mRNA differential expression in normal tissues according to GTEx for CHADL Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x10.5) and Brain - Substantia nigra (x5.2).

Protein differential expression in normal tissues from HIPED for CHADL Gene

This gene is overexpressed in Heart (50.3), Retina (9.3), and Ovary (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHADL Gene



SOURCE GeneReport for Unigene cluster for CHADL Gene Hs.344488

genes like me logo Genes that share expression patterns with CHADL: view

Protein tissue co-expression partners for CHADL Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CHADL Gene

Orthologs for CHADL Gene

This gene was present in the common ancestor of animals.

Orthologs for CHADL Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHADL 35
  • 86.59 (n)
  • 85.49 (a)
CHADL 36
  • 83 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHADL 35
  • 85.96 (n)
  • 82.85 (a)
CHADL 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chadl 35
  • 83.82 (n)
  • 82.29 (a)
Chadl 16
Chadl 36
  • 82 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHADL 35
  • 99.52 (n)
  • 99.08 (a)
CHADL 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chadl 35
  • 84.2 (n)
  • 83.36 (a)
oppossum
(Monodelphis domestica)
Mammalia CHADL 36
  • 44 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHADL 36
  • 65 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHADL 35
  • 63.66 (n)
  • 54.65 (a)
CHADL 36
  • 53 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 19 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia chadl 35
  • 52.3 (n)
  • 48.99 (a)
zebrafish
(Danio rerio)
Actinopterygii chadlb 35
  • 54.81 (n)
  • 49.36 (a)
chadla 36
  • 38 (a)
OneToMany
chadlb 36
  • 45 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta haf 36
  • 9 (a)
OneToMany
Species with no ortholog for CHADL:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHADL Gene

ENSEMBL:
Gene Tree for CHADL (if available)
TreeFam:
Gene Tree for CHADL (if available)

Paralogs for CHADL Gene

(3) SIMAP similar genes for CHADL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CHADL: view

Variants for CHADL Gene

Sequence variations from dbSNP and Humsavar for CHADL Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs9619955 - 41,235,278(+) CCCTC(C/T)GGCCA reference, missense
rs9619954 - 41,235,246(+) GCAGT(C/T)TTCAA reference, missense
rs139487 -- 41,232,060(+) gggcg(C/T)ggtgg intron-variant
rs139488 -- 41,232,136(+) GACCA(G/T)CCTGG intron-variant
rs139489 -- 41,232,150(+) ACACG(A/G)TGAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHADL Gene

Variant ID Type Subtype PubMed ID
nsv524585 CNV Loss 19592680
nsv915116 CNV Loss 21882294
nsv915117 CNV Loss 21882294
nsv915118 CNV Loss 21882294
nsv915119 CNV Loss 21882294
nsv459888 CNV Gain 19166990

Variation tolerance for CHADL Gene

Gene Damage Index Score: 6.66; 78.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHADL Gene

HapMap Linkage Disequilibrium report
CHADL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHADL Gene

Disorders for CHADL Gene

Relevant External Links for CHADL

Genetic Association Database (GAD)
CHADL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHADL

No disorders were found for CHADL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHADL Gene

Publications for CHADL Gene

  1. The novel small leucine-rich protein chondroadherin-like (CHADL) is expressed in cartilage and modulates chondrocyte differentiation. (PMID: 25451920) Tillgren V. … Kalamajski S. (J. Biol. Chem. 2015) 2 3 4 67
  2. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3
  3. Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. (PMID: 22261194) Barallobre-Barreiro J. … Mayr M. (Circulation 2012) 3
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3
  5. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) KAPnig R. … Chanda S.K. (Cell 2008) 3

Products for CHADL Gene

Sources for CHADL Gene

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