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Aliases for CHADL Gene

Aliases for CHADL Gene

  • Chondroadherin Like 2 3 5
  • SLRR4B 3 4
  • Chondroadherin-Like Protein 3
  • Chondroadherin-Like 2

External Ids for CHADL Gene

Previous GeneCards Identifiers for CHADL Gene

  • GC22U900391
  • GC22M039955
  • GC22M041625
  • GC22M024589
  • GC22M041213
  • GC22M041357

Summaries for CHADL Gene

GeneCards Summary for CHADL Gene

CHADL (Chondroadherin Like) is a Protein Coding gene. GO annotations related to this gene include collagen binding and collagen fibril binding. An important paralog of this gene is IGFALS.

UniProtKB/Swiss-Prot for CHADL Gene

  • Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocytes differentiation by acting on its cellular collagenous microenvironment.

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHADL Gene

Genomics for CHADL Gene

Regulatory Elements for CHADL Gene

Enhancers for CHADL Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH22G041409 2.1 FANTOM5 Ensembl ENCODE dbSUPER 4.9 -171.2 -171214 6.2 HDGF MLX WRNIP1 ARID4B SIN3A DMAP1 ZNF2 YY1 ZNF143 ZNF207 MEI1 EP300 POLR3H PHF5A CYP2D8P NAGA ENSG00000232754 ENSG00000272834 NDUFA6 TEF
GH22G041699 1.2 FANTOM5 Ensembl ENCODE 6.4 -458.1 -458079 1.7 CTCF HDGF ZNF680 RNF2 AGO1 NRF1 MAX E2F4 POLR2A ZBTB33 MEI1 CHADL WBP2NL ENSG00000273424 GC22M041711
GH22G041237 1.3 Ensembl ENCODE dbSUPER 5.1 +3.7 3667 2.1 BCOR RING1 CTCF MAX ZMYM3 RBBP5 UBTF RAD21 POLR2A ZNF143 CHADL GC22M041808
GH22G041401 1.6 FANTOM5 Ensembl ENCODE dbSUPER 3.7 -160.5 -160544 1.6 ELF3 TFAP4 SAP130 ZSCAN4 ARID4B SIN3A MAX BRCA1 RAD21 RFX5 MEI1 POLR3H CSDC2 ENSG00000235513 CHADL TEF TOB2 PIR55540 GC22P041413
GH22G040433 1.4 Ensembl ENCODE dbSUPER 4.1 +805.3 805269 6.0 FOXA2 TBL1XR1 WRNIP1 RAD21 TCF12 RELB IKZF2 CREM PAF1 ZNF654 MKL1 ENSG00000229999 SGSM3 LOC101927257 CHADL ENSG00000227413
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHADL on UCSC Golden Path with GeneCards custom track

Genomic Location for CHADL Gene

Chromosome:
22
Start:
41,209,869 bp from pter
End:
41,241,762 bp from pter
Size:
31,894 bases
Orientation:
Minus strand

Genomic View for CHADL Gene

Genes around CHADL on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHADL Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHADL Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHADL Gene

Proteins for CHADL Gene

  • Protein details for CHADL Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NUI6-CHADL_HUMAN
    Recommended name:
    Chondroadherin-like protein
    Protein Accession:
    Q6NUI6
    Secondary Accessions:
    • Q05CY2
    • Q4G0S0
    • Q5JY13
    • Q86XY1
    • Q96E60

    Protein attributes for CHADL Gene

    Size:
    762 amino acids
    Molecular mass:
    82388 Da
    Quaternary structure:
    • Associates with collagen and binds to collagen fibrils.
    SequenceCaution:
    • Sequence=AAH19839.1; Type=Frameshift; Positions=504; Evidence={ECO:0000305}; Sequence=AAH68590.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CHADL Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CHADL Gene

Post-translational modifications for CHADL Gene

  • Glycosylation at posLast=5252 and Asn626
  • Modification sites at PhosphoSitePlus

Other Protein References for CHADL Gene

No data available for DME Specific Peptides for CHADL Gene

Domains & Families for CHADL Gene

Suggested Antigen Peptide Sequences for CHADL Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NUI6

UniProtKB/Swiss-Prot:

CHADL_HUMAN :
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.
genes like me logo Genes that share domains with CHADL: view

No data available for Gene Families for CHADL Gene

Function for CHADL Gene

Molecular function for CHADL Gene

UniProtKB/Swiss-Prot Function:
Potential negative modulator of chondrocyte differentiation. Inhibits collagen fibrillogenesis in vitro. May influence chondrocytes differentiation by acting on its cellular collagenous microenvironment.

Gene Ontology (GO) - Molecular Function for CHADL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005518 collagen binding IDA 25451920
GO:0098633 collagen fibril binding IDA 25451920
genes like me logo Genes that share ontologies with CHADL: view

Phenotypes for CHADL Gene

GenomeRNAi human phenotypes for CHADL:
genes like me logo Genes that share phenotypes with CHADL: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CHADL

CRISPR Products

Inhibitory RNA Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CHADL Gene

Localization for CHADL Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHADL Gene

Secreted. Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHADL gene
Compartment Confidence
extracellular 5
mitochondrion 3
peroxisome 1
lysosome 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CHADL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0031012 colocalizes_with extracellular matrix IDA,ISS 22261194
genes like me logo Genes that share ontologies with CHADL: view

Pathways & Interactions for CHADL Gene

SuperPathways for CHADL Gene

No Data Available

Interacting Proteins for CHADL Gene

Gene Ontology (GO) - Biological Process for CHADL Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0032331 negative regulation of chondrocyte differentiation IEA,ISS --
GO:1904027 negative regulation of collagen fibril organization IDA 25451920
genes like me logo Genes that share ontologies with CHADL: view

No data available for Pathways by source and SIGNOR curated interactions for CHADL Gene

Drugs & Compounds for CHADL Gene

No Compound Related Data Available

Transcripts for CHADL Gene

Unigene Clusters for CHADL Gene

Chondroadherin-like:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHADL Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6a · 6b
SP1: - - -
SP2: -
SP3:

Relevant External Links for CHADL Gene

GeneLoc Exon Structure for
CHADL
ECgene alternative splicing isoforms for
CHADL

Expression for CHADL Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CHADL Gene

mRNA differential expression in normal tissues according to GTEx for CHADL Gene

This gene is overexpressed in Brain - Spinal cord (cervical c-1) (x10.5) and Brain - Substantia nigra (x5.2).

Protein differential expression in normal tissues from HIPED for CHADL Gene

This gene is overexpressed in Heart (50.3), Retina (9.3), and Ovary (8.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHADL Gene



Protein tissue co-expression partners for CHADL Gene

NURSA nuclear receptor signaling pathways regulating expression of CHADL Gene:

CHADL

SOURCE GeneReport for Unigene cluster for CHADL Gene:

Hs.344488

Evidence on tissue expression from TISSUES for CHADL Gene

  • Nervous system(4.4)
genes like me logo Genes that share expression patterns with CHADL: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CHADL Gene

Orthologs for CHADL Gene

This gene was present in the common ancestor of animals.

Orthologs for CHADL Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHADL 34 35
  • 99.52 (n)
cow
(Bos Taurus)
Mammalia CHADL 34 35
  • 86.59 (n)
dog
(Canis familiaris)
Mammalia CHADL 34 35
  • 85.96 (n)
rat
(Rattus norvegicus)
Mammalia Chadl 34
  • 84.2 (n)
mouse
(Mus musculus)
Mammalia Chadl 34 16 35
  • 83.82 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia CHADL 35
  • 65 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CHADL 35
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHADL 34 35
  • 63.66 (n)
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 19 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia chadl 34
  • 52.3 (n)
zebrafish
(Danio rerio)
Actinopterygii chadlb 34 35
  • 54.81 (n)
chadla 35
  • 38 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta haf 35
  • 9 (a)
OneToMany
Species where no ortholog for CHADL was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHADL Gene

ENSEMBL:
Gene Tree for CHADL (if available)
TreeFam:
Gene Tree for CHADL (if available)

Paralogs for CHADL Gene

(3) SIMAP similar genes for CHADL Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CHADL: view

Variants for CHADL Gene

Sequence variations from dbSNP and Humsavar for CHADL Gene

SNP ID Clin Chr 22 pos Sequence Context AA Info Type
rs1000054281 -- 41,241,667(+) ATCTT(C/G)ATTTT upstream-variant-2KB, utr-variant-5-prime
rs1000070747 -- 41,235,482(+) CTCAA(A/C)AAGCA intron-variant
rs1000360076 -- 41,215,347(+) TTAAC(A/G)ATCTT intron-variant
rs1000363070 -- 41,241,378(+) AAATA(A/G)TTTAA upstream-variant-2KB, utr-variant-5-prime
rs1000424836 -- 41,228,020(+) CTCTT(C/T)CCCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CHADL Gene

Variant ID Type Subtype PubMed ID
esv3647794 CNV loss 21293372
nsv459888 CNV gain 19166990
nsv524585 CNV loss 19592680
nsv589049 CNV gain 21841781
nsv589050 CNV gain 21841781

Variation tolerance for CHADL Gene

Gene Damage Index Score: 6.66; 78.43% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHADL Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHADL

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHADL Gene

Disorders for CHADL Gene

Relevant External Links for CHADL

Genetic Association Database (GAD)
CHADL
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHADL

No disorders were found for CHADL Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHADL Gene

Publications for CHADL Gene

  1. The novel small leucine-rich protein chondroadherin-like (CHADL) is expressed in cartilage and modulates chondrocyte differentiation. (PMID: 25451920) Tillgren V. … Kalamajski S. (J. Biol. Chem. 2015) 2 3 4 64
  2. Biological insights from 108 schizophrenia-associated genetic loci. (PMID: 25056061) (Nature 2014) 3 64
  3. Proteomics analysis of cardiac extracellular matrix remodeling in a porcine model of ischemia/reperfusion injury. (PMID: 22261194) Barallobre-Barreiro J. … Mayr M. (Circulation 2012) 3 64
  4. Toward a confocal subcellular atlas of the human proteome. (PMID: 18029348) Barbe L. … Andersson-Svahn H. (Mol. Cell Proteomics 2008) 3 64
  5. Global analysis of host-pathogen interactions that regulate early-stage HIV-1 replication. (PMID: 18854154) KAPnig R. … Chanda S.K. (Cell 2008) 3 64

Products for CHADL Gene

Sources for CHADL Gene

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