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Aliases for CHAD Gene

Aliases for CHAD Gene

  • Chondroadherin 2 3 3 5
  • Cartilage Leucine-Rich Protein 3 4
  • Chondroadherin Proteoglycan 2 3
  • SLRR4A 3 4

External Ids for CHAD Gene

Previous GeneCards Identifiers for CHAD Gene

  • GC17M048254
  • GC17M051023
  • GC17M048883
  • GC17M049016
  • GC17M045896
  • GC17M048541
  • GC17M043909

Summaries for CHAD Gene

Entrez Gene Summary for CHAD Gene

  • Chondroadherin is a cartilage matrix protein thought to mediate adhesion of isolated chondrocytes. The protein contains 11 leucine-rich repeats flanked by cysteine-rich regions. The chondroadherin messenger RNA is present in chondrocytes at all ages. [provided by RefSeq, Jul 2008]

GeneCards Summary for CHAD Gene

CHAD (Chondroadherin) is a Protein Coding gene. Among its related pathways are ECM-receptor interaction and Focal Adhesion. An important paralog of this gene is IGFALS.

UniProtKB/Swiss-Prot for CHAD Gene

  • Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHAD Gene

Genomics for CHAD Gene

Regulatory Elements for CHAD Gene

Enhancers for CHAD Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH17F050171 1.8 FANTOM5 Ensembl ENCODE 9.8 +277.1 277118 42.5 CREB3L1 ZFP64 YBX1 FEZF1 DMAP1 YY1 ZNF143 ZNF263 SP3 TBX21 ENSG00000262837 SGCA FLJ45513 TMEM92-AS1 COL1A1 TMEM92 XYLT2 PPP1R9B ENSG00000253730 SAMD14
GH17F050423 1.4 Ensembl ENCODE 11.7 +42.9 42889 6.9 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 SLC30A9 ZNF143 RSAD1 ENSG00000262837 CHAD ENSG00000253102 LRRC59 UTP18 CACNA1G-AS1 EPN3 MYCBPAP CACNA1G
GH17F050633 1.4 FANTOM5 ENCODE 11.6 -169.1 -169071 10.1 PKNOX1 CREB3L1 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 FOS ABCC3 CHAD LOC105371823 MYCBPAP CACNA1G CACNA1G-AS1 SPATA20 LOC105371824 EPN3 ANKRD40
GH17F050870 1.2 FANTOM5 Ensembl ENCODE 13 -402.2 -402220 3.0 TFAP4 SAP130 FOXA3 SIN3A ZMYM3 MAX HMG20A MNT RAD21 ZNF121 CHAD ENSG00000247011 ENSG00000251665 TOB1-AS1 MYCBPAP CACNA1G GC17M050874 TOB1
GH17F050659 1.4 Ensembl ENCODE 10.2 -192.1 -192099 4.9 HDGF PKNOX1 ARNT MLX ZFP64 ARID4B SIN3A DMAP1 YY1 ZNF207 ABCC3 ANKRD40 LOC101927253 CACNA1G-AS1 CACNA1G ACSF2 SPATA20 EPN3 LOC105371824 MYCBPAP
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CHAD on UCSC Golden Path with GeneCards custom track

Promoters for CHAD Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001808024 581 201 HDGF BRD4 LEF1 IRF2 PKNOX1 NFRKB ZNF76 FEZF1 CDC5L ZNF766

Genomic Location for CHAD Gene

Chromosome:
17
Start:
50,464,492 bp from pter
End:
50,469,881 bp from pter
Size:
5,390 bases
Orientation:
Minus strand

Genomic View for CHAD Gene

Genes around CHAD on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHAD Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHAD Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHAD Gene

Proteins for CHAD Gene

  • Protein details for CHAD Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15335-CHAD_HUMAN
    Recommended name:
    Chondroadherin
    Protein Accession:
    O15335
    Secondary Accessions:
    • A8K812
    • Q6GTU0
    • Q96RJ5

    Protein attributes for CHAD Gene

    Size:
    359 amino acids
    Molecular mass:
    40476 Da
    Quaternary structure:
    • Mostly monomeric (By similarity). Interacts with collagen type II.

neXtProt entry for CHAD Gene

Post-translational modifications for CHAD Gene

  • Glycosylation at Ser 144
  • Modification sites at PhosphoSitePlus

Other Protein References for CHAD Gene

Antibody Products

  • R&D Systems Antibodies for CHAD (Chondroadherin)
  • Abcam antibodies for CHAD

No data available for DME Specific Peptides for CHAD Gene

Domains & Families for CHAD Gene

Gene Families for CHAD Gene

Suggested Antigen Peptide Sequences for CHAD Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15335

UniProtKB/Swiss-Prot:

CHAD_HUMAN :
  • Contains 1 LRRCT domain.
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.
  • Contains 9 LRR (leucine-rich) repeats.
Domain:
  • Contains 1 LRRCT domain.
  • Contains 1 LRRNT domain.
Family:
  • Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class IV subfamily.
Similarity:
  • Contains 9 LRR (leucine-rich) repeats.
genes like me logo Genes that share domains with CHAD: view

Function for CHAD Gene

Molecular function for CHAD Gene

GENATLAS Biochemistry:
chondroadherin,36kDa,expressed in chodrocytes,leucine-rich repeat (LRR) family
UniProtKB/Swiss-Prot Function:
Promotes attachment of chondrocytes, fibroblasts, and osteoblasts. This binding is mediated (at least for chondrocytes and fibroblasts) by the integrin alpha(2)beta(1). May play an important role in the regulation of chondrocyte growth and proliferation (By similarity).

Gene Ontology (GO) - Molecular Function for CHAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004860 protein kinase inhibitor activity IBA --
genes like me logo Genes that share ontologies with CHAD: view

Phenotypes for CHAD Gene

genes like me logo Genes that share phenotypes with CHAD: view

Animal Models for CHAD Gene

MGI Knock Outs for CHAD:

Animal Model Products

  • Taconic Biosciences Mouse Models for CHAD

Inhibitory RNA Products

Clone Products

Cell Line Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CHAD Gene

Localization for CHAD Gene

Subcellular locations from UniProtKB/Swiss-Prot for CHAD Gene

Secreted, extracellular space, extracellular matrix.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CHAD gene
Compartment Confidence
extracellular 5
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CHAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
GO:0005578 proteinaceous extracellular matrix IEA --
GO:0005737 cytoplasm IBA --
genes like me logo Genes that share ontologies with CHAD: view

Pathways & Interactions for CHAD Gene

genes like me logo Genes that share pathways with CHAD: view

Pathways by source for CHAD Gene

1 BioSystems pathway for CHAD Gene

Gene Ontology (GO) - Biological Process for CHAD Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006469 negative regulation of protein kinase activity IBA --
GO:0019221 cytokine-mediated signaling pathway IBA --
GO:0046426 negative regulation of JAK-STAT cascade IBA --
GO:0060348 bone development IEA --
GO:1900155 negative regulation of bone trabecula formation IEA --
genes like me logo Genes that share ontologies with CHAD: view

No data available for SIGNOR curated interactions for CHAD Gene

Drugs & Compounds for CHAD Gene

(1) Drugs for CHAD Gene - From: Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials

(1) Additional Compounds for CHAD Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CHAD: view

Transcripts for CHAD Gene

mRNA/cDNA for CHAD Gene

Unigene Clusters for CHAD Gene

Chondroadherin:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHAD Gene

No ASD Table

Relevant External Links for CHAD Gene

GeneLoc Exon Structure for
CHAD
ECgene alternative splicing isoforms for
CHAD

Expression for CHAD Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CHAD Gene

mRNA differential expression in normal tissues according to GTEx for CHAD Gene

This gene is overexpressed in Brain - Cerebellar Hemisphere (x5.2), Brain - Cerebellum (x5.1), Liver (x5.1), and Pancreas (x4.7).

Protein differential expression in normal tissues from HIPED for CHAD Gene

This gene is overexpressed in Synovial fluid (36.1), Serum (23.9), and Breast (7.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CHAD Gene



Protein tissue co-expression partners for CHAD Gene

NURSA nuclear receptor signaling pathways regulating expression of CHAD Gene:

CHAD

SOURCE GeneReport for Unigene cluster for CHAD Gene:

Hs.97220

mRNA Expression by UniProt/SwissProt for CHAD Gene:

O15335-CHAD_HUMAN
Tissue specificity: Present in chondrocytes at all ages.
genes like me logo Genes that share expression patterns with CHAD: view

Orthologs for CHAD Gene

This gene was present in the common ancestor of animals.

Orthologs for CHAD Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CHAD 34 35
  • 99.44 (n)
cow
(Bos Taurus)
Mammalia CHAD 34 35
  • 91.89 (n)
dog
(Canis familiaris)
Mammalia CHAD 34 35
  • 90.81 (n)
rat
(Rattus norvegicus)
Mammalia Chad 34
  • 87.93 (n)
mouse
(Mus musculus)
Mammalia Chad 34 16 35
  • 87.44 (n)
oppossum
(Monodelphis domestica)
Mammalia CHAD 35
  • 87 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHAD 34 35
  • 71.61 (n)
lizard
(Anolis carolinensis)
Reptilia CHAD 35
  • 71 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chad 34
  • 68.84 (n)
zebrafish
(Danio rerio)
Actinopterygii chad 34 35
  • 64.48 (n)
fruit fly
(Drosophila melanogaster)
Insecta haf 35
  • 7 (a)
OneToMany
Species where no ortholog for CHAD was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHAD Gene

ENSEMBL:
Gene Tree for CHAD (if available)
TreeFam:
Gene Tree for CHAD (if available)

Paralogs for CHAD Gene

(5) SIMAP similar genes for CHAD Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CHAD: view

Variants for CHAD Gene

Sequence variations from dbSNP and Humsavar for CHAD Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type
rs1052255 -- 50,464,578(-) GCAGG(A/T)CATCG intron-variant, nc-transcript-variant, reference, utr-variant-3-prime, stop-gained
rs10707664 -- 50,466,089(+) TTTTT(-/T)CCTTT intron-variant
rs111276495 -- 50,470,681(+) GCCAG(A/G)GGATG intron-variant, upstream-variant-2KB
rs112560818 -- 50,470,636(+) GGAGC(C/G)GGGGA intron-variant, upstream-variant-2KB
rs112633417 -- 50,469,319(+) GCGGG(A/G)CCGGA intron-variant, upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CHAD Gene

Variant ID Type Subtype PubMed ID
nsv2081 CNV deletion 18451855
nsv833476 CNV loss 17160897
nsv952340 CNV deletion 24416366

Variation tolerance for CHAD Gene

Residual Variation Intolerance Score: 58.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.31; 62.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHAD Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CHAD

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHAD Gene

Disorders for CHAD Gene

Relevant External Links for CHAD

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHAD

No disorders were found for CHAD Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHAD Gene

Publications for CHAD Gene

  1. The structure and chromosome location of the human chondroadherin gene (CHAD). (PMID: 9344663) Grover J. … Roughley P.J. (Genomics 1997) 2 3 4 22 64
  2. Association of chondroadherin with collagen type II. (PMID: 11445564) Maansson B. … Heinegaard D. (J. Biol. Chem. 2001) 3 4 22 64
  3. Variation in chondroadherin abundance and fragmentation in the human scoliotic disc. (PMID: 19525844) Haglund L. … Roughley P. (Spine 2009) 3 22 64
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  5. Integrin alpha2beta1 is a receptor for the cartilage matrix protein chondroadherin. (PMID: 9281592) Camper L. … Lundgren-Akerlund E. (J. Cell Biol. 1997) 3 22 64

Products for CHAD Gene

Sources for CHAD Gene

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