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Aliases for CHAC2 Gene

Aliases for CHAC2 Gene

  • ChaC, Cation Transport Regulator Homolog 2 (E. Coli) 2 3
  • ChaC, Cation Transport Regulator-Like 2 (E. Coli) 2
  • Gamma-GCT Acting On Glutathione Homolog 2 2
  • Cation Transport Regulator-Like Protein 2 4
  • Gamma-GCG 2 4
  • EC 2.3.2.- 4

External Ids for CHAC2 Gene

Summaries for CHAC2 Gene

GeneCards Summary for CHAC2 Gene

CHAC2 (ChaC, Cation Transport Regulator Homolog 2 (E. Coli)) is a Protein Coding gene. An important paralog of this gene is CHAC1.

UniProtKB/Swiss-Prot for CHAC2 Gene

  • Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHAC2 Gene

Genomics for CHAC2 Gene

Genomic Location for CHAC2 Gene

53,767,792 bp from pter
53,775,196 bp from pter
7,405 bases
Plus strand

Genomic View for CHAC2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CHAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHAC2 Gene

Regulatory Elements for CHAC2 Gene

Proteins for CHAC2 Gene

  • Protein details for CHAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Putative glutathione-specific gamma-glutamylcyclotransferase 2
    Protein Accession:
    Secondary Accessions:
    • Q8WVI8

    Protein attributes for CHAC2 Gene

    184 amino acids
    Molecular mass:
    20875 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHAC2 Gene

Proteomics data for CHAC2 Gene at MOPED

Post-translational modifications for CHAC2 Gene

  • Modification sites at PhosphoSitePlus
  • Ubiquitination at Lys178

Other Protein References for CHAC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHAC2 Gene

Domains for CHAC2 Gene

Protein Domains for CHAC2 Gene



  • Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.:
    • Q8WUX2
genes like me logo Genes that share domains with CHAC2: view

No data available for Gene Families for CHAC2 Gene

Function for CHAC2 Gene

Molecular function for CHAC2 Gene

UniProtKB/Swiss-Prot CatalyticActivity: Glutathione = 5-oxoproline + cysteinylglycine.
UniProtKB/Swiss-Prot Function: Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

Enzyme Numbers (IUBMB) for CHAC2 Gene

Gene Ontology (GO) - Molecular Function for CHAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with CHAC2: view

No data available for Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CHAC2 Gene

Localization for CHAC2 Gene

Subcellular locations from

Jensen Localization Image for CHAC2 Gene COMPARTMENTS Subcellular localization image for CHAC2 gene
Compartment Confidence
cytosol 2

Gene Ontology (GO) - Cellular Components for CHAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005575 cellular_component ND --
genes like me logo Genes that share ontologies with CHAC2: view

Pathways for CHAC2 Gene

SuperPathways for CHAC2 Gene

No Data Available

Interacting Proteins for CHAC2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
Selected Interacting proteins: ENSP00000295304 Q8WUX2-CHAC2_HUMAN for CHAC2 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CHAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008150 biological_process ND --
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with CHAC2: view

No data available for Pathways by source for CHAC2 Gene

Transcripts for CHAC2 Gene

mRNA/cDNA for CHAC2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHAC2 Gene

ChaC, cation transport regulator homolog 2 (E. coli):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CHAC2 Gene

No ASD Table

Relevant External Links for CHAC2 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CHAC2 Gene

mRNA expression in normal human tissues for CHAC2 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CHAC2 Gene

SOURCE GeneReport for Unigene cluster for CHAC2 Gene Hs.585944

genes like me logo Genes that share expressions with CHAC2: view

Orthologs for CHAC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHAC2 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CHAC2 36
  • 99.64 (n)
  • 100 (a)
CHAC2 37
  • 100 (a)
(Bos Taurus)
Mammalia CHAC2 36
  • 92.64 (n)
  • 91.86 (a)
CHAC2 37
  • 90 (a)
(Canis familiaris)
Mammalia CHAC2 36
  • 95.47 (n)
  • 94.57 (a)
CHAC2 37
  • 85 (a)
(Mus musculus)
Mammalia Chac2 36
  • 91.76 (n)
  • 93.82 (a)
Chac2 16
Chac2 37
  • 94 (a)
(Monodelphis domestica)
Mammalia CHAC2 37
  • 80 (a)
(Ornithorhynchus anatinus)
Mammalia CHAC2 37
  • 68 (a)
(Rattus norvegicus)
Mammalia Chac2 36
  • 91.95 (n)
  • 94.38 (a)
(Gallus gallus)
Aves CHAC2 36
  • 78.49 (n)
  • 83.72 (a)
CHAC2 37
  • 78 (a)
(Anolis carolinensis)
Reptilia CHAC2 37
  • 54 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia chac2 36
  • 79.71 (n)
  • 87.5 (a)
(Danio rerio)
Actinopterygii chac2 36
  • 67.05 (n)
  • 72.16 (a)
chac2 37
  • 69 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002216 36
  • 53.64 (n)
  • 51.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2540 36
  • 52.05 (n)
  • 50.29 (a)
CG2540 37
  • 26 (a)
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR184C 36
  • 47.62 (n)
  • 41.56 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes -- 37
  • 30 (a)
-- 39
GCG1 36
  • 49.46 (n)
  • 42.58 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C11649g 36
  • 47.29 (n)
  • 41.28 (a)
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G44790 36
  • 52.06 (n)
  • 46.63 (a)
(Oryza sativa)
Liliopsida Os04g0448600 36
  • 57.95 (n)
  • 47.71 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02737 36
  • 48.8 (n)
  • 47.06 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC31F10.03 36
  • 48.19 (n)
  • 41.71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 37
  • 60 (a)
Species with no ortholog for CHAC2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHAC2 Gene

Gene Tree for CHAC2 (if available)
Gene Tree for CHAC2 (if available)

Paralogs for CHAC2 Gene

Paralogs for CHAC2 Gene

Selected SIMAP similar genes for CHAC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CHAC2: view

Variants for CHAC2 Gene

Sequence variations from dbSNP and Humsavar for CHAC2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
VAR_038123 -

Structural Variations from Database of Genomic Variants (DGV) for CHAC2 Gene

Variant ID Type Subtype PubMed ID
nsv834058 CNV Gain+Loss 17160897

Relevant External Links for CHAC2 Gene

HapMap Linkage Disequilibrium report

Disorders for CHAC2 Gene

No disorders were found for CHAC2 Gene.

No data available for UniProtKB/Swiss-Prot for CHAC2 Gene

Publications for CHAC2 Gene

  1. Mammalian proapoptotic factor ChaC1 and its homologues function as I^-glutamyl cyclotransferases acting specifically on glutathione. (PMID: 23070364) Kumar A. … Bachhawat A.K. (EMBO Rep. 2012) 2 3
  2. A COFRADIC protocol to study protein ubiquitination. (PMID: 24816145) Stes E. … Gevaert K. (J. Proteome Res. 2014) 3
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4
  4. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CHAC2 Gene

Sources for CHAC2 Gene

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