Aliases for CHAC2 Gene
External Ids for CHAC2 Gene
Previous GeneCards Identifiers for CHAC2 Gene
The protein encoded by this gene is a gamma-glutamyl cyclotransferase that catalyzes the conversion of glutathione to 5-oxoproline and cysteinylglycine. It is thought that this gene is upregulated in response to endoplasmic reticulum stress and that the glutathione depletion enhances apoptosis. [provided by RefSeq, Sep 2016]
GeneCards Summary for CHAC2 Gene
CHAC2 (ChaC Cation Transport Regulator Homolog 2) is a Protein Coding gene. Among its related pathways are Glutathione metabolism and Cytochrome P450 - arranged by substrate type. GO annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is CHAC1.
UniProtKB/Swiss-Prot for CHAC2 Gene
Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.