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Aliases for CHAC2 Gene

Aliases for CHAC2 Gene

  • ChaC, Cation Transport Regulator Homolog 2 (E. Coli) 2 3 5
  • ChaC, Cation Transport Regulator-Like 2 (E. Coli) 2
  • Gamma-GCT Acting On Glutathione Homolog 2 2
  • Cation Transport Regulator-Like Protein 2 4
  • Gamma-GCG 2 4
  • EC 2.3.2.- 4

External Ids for CHAC2 Gene

Previous GeneCards Identifiers for CHAC2 Gene

  • GC02U900806
  • GC02P053848
  • GC02P053994
  • GC02P053729

Summaries for CHAC2 Gene

GeneCards Summary for CHAC2 Gene

CHAC2 (ChaC, Cation Transport Regulator Homolog 2 (E. Coli)) is a Protein Coding gene. Among its related pathways are Metabolism and Phase II conjugation. GO annotations related to this gene include transferase activity, transferring acyl groups. An important paralog of this gene is CHAC1.

UniProtKB/Swiss-Prot for CHAC2 Gene

  • Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CHAC2 Gene

Genomics for CHAC2 Gene

Regulatory Elements for CHAC2 Gene

Promoters for CHAC2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CHAC2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CHAC2 Gene

Chromosome:
2
Start:
53,767,792 bp from pter
End:
53,775,196 bp from pter
Size:
7,405 bases
Orientation:
Plus strand

Genomic View for CHAC2 Gene

Genes around CHAC2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CHAC2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CHAC2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CHAC2 Gene

Proteins for CHAC2 Gene

  • Protein details for CHAC2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8WUX2-CHAC2_HUMAN
    Recommended name:
    Putative glutathione-specific gamma-glutamylcyclotransferase 2
    Protein Accession:
    Q8WUX2
    Secondary Accessions:
    • Q8WVI8

    Protein attributes for CHAC2 Gene

    Size:
    184 amino acids
    Molecular mass:
    20875 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CHAC2 Gene

Proteomics data for CHAC2 Gene at MOPED

Post-translational modifications for CHAC2 Gene

  • Ubiquitination at Lys 178
  • Modification sites at PhosphoSitePlus

Other Protein References for CHAC2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CHAC2 Gene

Domains & Families for CHAC2 Gene

Protein Domains for CHAC2 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CHAC2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q8WUX2

UniProtKB/Swiss-Prot:

CHAC2_HUMAN :
  • Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
Family:
  • Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.
genes like me logo Genes that share domains with CHAC2: view

No data available for Gene Families for CHAC2 Gene

Function for CHAC2 Gene

Molecular function for CHAC2 Gene

UniProtKB/Swiss-Prot CatalyticActivity:
Glutathione = 5-oxoproline + cysteinylglycine.
UniProtKB/Swiss-Prot Function:
Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides.

Enzyme Numbers (IUBMB) for CHAC2 Gene

Gene Ontology (GO) - Molecular Function for CHAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016746 transferase activity, transferring acyl groups IEA --
genes like me logo Genes that share ontologies with CHAC2: view
genes like me logo Genes that share phenotypes with CHAC2: view

Animal Model Products

No data available for Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CHAC2 Gene

Localization for CHAC2 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CHAC2 Gene COMPARTMENTS Subcellular localization image for CHAC2 gene
Compartment Confidence
cytosol 5

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CHAC2 Gene

Pathways & Interactions for CHAC2 Gene

genes like me logo Genes that share pathways with CHAC2: view

Pathways by source for CHAC2 Gene

Interacting Proteins for CHAC2 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000295304%0d%0a9606.ENSP00000359211%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000406598%0d%0a9606.ENSP00000304697%0d%0a
Selected Interacting proteins: Q8WUX2-CHAC2_HUMAN ENSP00000295304 for CHAC2 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for CHAC2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with CHAC2: view

No data available for SIGNOR curated interactions for CHAC2 Gene

Drugs & Compounds for CHAC2 Gene

No Compound Related Data Available

Transcripts for CHAC2 Gene

mRNA/cDNA for CHAC2 Gene

(1) REFSEQ mRNAs :
(5) Additional mRNA sequences :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CHAC2 Gene

ChaC, cation transport regulator homolog 2 (E. coli):
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CHAC2 Gene

No ASD Table

Relevant External Links for CHAC2 Gene

GeneLoc Exon Structure for
CHAC2
ECgene alternative splicing isoforms for
CHAC2

Expression for CHAC2 Gene

mRNA expression in normal human tissues for CHAC2 Gene

Protein differential expression in normal tissues from HIPED for CHAC2 Gene

This gene is overexpressed in Testis (33.4), Retina (13.4), Fetal Liver (10.2), and Tonsil (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, MOPED, and MaxQB for CHAC2 Gene



SOURCE GeneReport for Unigene cluster for CHAC2 Gene Hs.585944

genes like me logo Genes that share expression patterns with CHAC2: view

Protein tissue co-expression partners for CHAC2 Gene

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CHAC2 Gene

Orthologs for CHAC2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CHAC2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CHAC2 35
  • 92.64 (n)
  • 91.86 (a)
CHAC2 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CHAC2 35
  • 95.47 (n)
  • 94.57 (a)
CHAC2 36
  • 85 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Chac2 35
  • 91.76 (n)
  • 93.82 (a)
Chac2 16
Chac2 36
  • 94 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CHAC2 35
  • 99.64 (n)
  • 100 (a)
CHAC2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Chac2 35
  • 91.95 (n)
  • 94.38 (a)
oppossum
(Monodelphis domestica)
Mammalia CHAC2 36
  • 80 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CHAC2 36
  • 68 (a)
OneToOne
chicken
(Gallus gallus)
Aves CHAC2 35
  • 78.49 (n)
  • 83.72 (a)
CHAC2 36
  • 78 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CHAC2 36
  • 54 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia chac2 35
  • 79.71 (n)
  • 87.5 (a)
zebrafish
(Danio rerio)
Actinopterygii chac2 35
  • 67.05 (n)
  • 72.16 (a)
chac2 36
  • 69 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP002216 35
  • 53.64 (n)
  • 51.15 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG2540 35
  • 52.05 (n)
  • 50.29 (a)
CG2540 36
  • 26 (a)
OneToOne
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AFR184C 35
  • 47.62 (n)
  • 41.56 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C11649g 35
  • 47.29 (n)
  • 41.28 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes GCG1 35
  • 49.46 (n)
  • 42.58 (a)
-- 36
  • 30 (a)
OneToMany
GCG1 38
thale cress
(Arabidopsis thaliana)
eudicotyledons AT1G44790 35
  • 52.06 (n)
  • 46.63 (a)
rice
(Oryza sativa)
Liliopsida Os04g0448600 35
  • 57.95 (n)
  • 47.71 (a)
bread mold
(Neurospora crassa)
Ascomycetes NCU02737 35
  • 48.8 (n)
  • 47.06 (a)
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes SPBC31F10.03 35
  • 48.19 (n)
  • 41.71 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 60 (a)
OneToOne
Species with no ortholog for CHAC2:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CHAC2 Gene

ENSEMBL:
Gene Tree for CHAC2 (if available)
TreeFam:
Gene Tree for CHAC2 (if available)

Paralogs for CHAC2 Gene

Paralogs for CHAC2 Gene

(1) SIMAP similar genes for CHAC2 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CHAC2: view

Variants for CHAC2 Gene

Sequence variations from dbSNP and Humsavar for CHAC2 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
VAR_038123 -

Structural Variations from Database of Genomic Variants (DGV) for CHAC2 Gene

Variant ID Type Subtype PubMed ID
nsv834058 CNV Gain+Loss 17160897

Variation tolerance for CHAC2 Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.96; 19.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CHAC2 Gene

HapMap Linkage Disequilibrium report
CHAC2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CHAC2 Gene

Disorders for CHAC2 Gene

Relevant External Links for CHAC2

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CHAC2

No disorders were found for CHAC2 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CHAC2 Gene

Publications for CHAC2 Gene

  1. Mammalian proapoptotic factor ChaC1 and its homologues function as I^-glutamyl cyclotransferases acting specifically on glutathione. (PMID: 23070364) Kumar A. … Bachhawat A.K. (EMBO Rep. 2012) 2 3 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. A census of human soluble protein complexes. (PMID: 22939629) Havugimana P.C. … Emili A. (Cell 2012) 3
  4. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3
  5. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PMID: 17207965) Lamesch P. … Vidal M. (Genomics 2007) 3

Products for CHAC2 Gene

Sources for CHAC2 Gene

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