CHAC2 Gene
protein-coding GIFtS: 40
GCID: GC02P053994
|
|
ChaC, cation transport regulator homolog 2 (E. coli)(Previous names: ChaC, cation transport regulator-like 2 (E. coli) )
| |
Aliases
for CHAC2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| ChaC, Cation Transport Regulator Homolog 2 (E. Coli)1 2 | | ChaC, Cation Transport Regulator-Like 2 (E. Coli)1 | | Cation Transport Regulator-Like Protein 22 | | ChaC, Cation Transport Regulator-Like 22 |
Export aliases for CHAC2 gene to outside databasesPrevious GC identifers: GC02U900806 GC02P053848 GC02P053729 |
Summaries
for CHAC2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
-- |
Genomic Views
for CHAC2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000002.11 NC_018913.1 NT_022184.15
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CHAC2 gene promoter:
Nkx2-2 p300 FOXO3 FOXO3b C/EBPalpha POU2F1 POU2F1b POU2F1a FOXO3a POU2F1c
Other transcription factors
Search SABiosciences Chromatin IP Primers for CHAC2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHAC2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 2p16 Ensembl cytogenetic band: 2p16.2 HGNC cytogenetic band: 2p16CHAC2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 2 GeneLoc Exon Structure GeneLoc location for GC02P053994: view genomic region
(about GC identifiers)
Start:
|
53,994,929 bp from pter |
End:
|
54,002,333 bp from pter |
Size:
|
7,405 bases |
Orientation:
|
plus strand |
|
Proteins
for CHAC2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CHAC2_HUMAN, Q8WUX2 (See
protein sequence)Recommended Name: Cation transport regulator-like protein 2 Size: 184 amino acids; 20875 Da
Secondary accessions: Q8WVI8Explore the universe of human proteins at neXtProt for CHAC2: NX_Q8WUX2
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q8WUX2
CHAC2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_001008708.1
ENSEMBL proteins: ENSP00000295304
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005575 | cellular_component |
ND | -- |
CHAC2 for ontologies About GeneDecksing
CHAC2 Antibody Products:
Assay Products for CHAC2: |
Protein
Domains /
Families
for CHAC2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CHAC2 for domains About GeneDecksing
2 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q8WUX2ProtoNet protein and cluster: Q8WUX2 UniProtKB/Swiss-Prot: CHAC2_HUMAN, Q8WUX2Similarity: Belongs to the chaC family |
Function
for CHAC2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHAC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHAC2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
| |  | GenScript: all cDNA clones in your preferred vector: CHAC2 (NM_001008708) | |  | Browse Sino Biological Human cDNA Clones | |  | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHAC2 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHAC2 |
In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHAC2 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0003674 | molecular_function |
ND | -- |
CHAC2 for ontologies About GeneDecksing
|
Pathways & Interactions
for CHAC2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CHAC2
STRING Interaction
Network Preview (showing 2 interactants - click image to see more details)
5/15 Interacting proteins for CHAC2 (Q8WUX23 ENSP000002953044) via UniProtKB, MINT, STRING, and/or I2D (see all 15)About this table
Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0008150 | biological_process |
ND | -- |
CHAC2 for ontologies About GeneDecksing
|
Drugs & Compounds
for CHAC2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CHAC2
Search CenterWatch for drugs/clinical trials and news about CHAC2
|
Transcripts
for CHAC2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CHAC2 gene: NM_001008708.2 Unigene Cluster for CHAC2: ChaC, cation transport regulator homolog 2 (E. coli) Hs.585944 [show with all ESTs]Unigene Representative Sequence: AK0972601 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000295304(uc002rxk.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHAC2 (see all 3)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHAC2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CHAC2 (NM_001008708) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CHAC2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHAC2 |
Additional cDNA sequence: AK097260.1 BC017941.1 BC019239.1 BC025376.1 BC053896.1 3 DOTS entries: DT.40199260 DT.91831291 DT.99935593
GeneLoc Exon Structure
|
Expression
for CHAC2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CHAC2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CTTAGAAATA
About this image
See CHAC2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CHAC2
SOURCE GeneReport for Unigene cluster: Hs.585944
SABiosciences Custom PCR Arrays for CHAC2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHAC2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CHAC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHAC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHAC2 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHAC2 |
Orthologs
for CHAC2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the last universal common ancestor (LUCA).
Orthologs for CHAC2 gene from 8/29 species (see all 29) About this table
ENSEMBL Gene Tree for CHAC2 (if available)
TreeFam Gene Tree for CHAC2 (if available) |
Paralogs
for CHAC2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CHAC2 gene
- CHAC12
1 SIMAP similar gene for CHAC2 using alignment to 1 protein entry: CHAC2_HUMAN:CHAC1
CHAC2 for paralogs About GeneDecksing
|
Genomic Variants
for CHAC2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CHAC2
1 CNV: 4285 | SABiosciences Cancer Mutation PCR Assays |
|
Disorders
/ Diseases
for CHAC2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
| -- |
Publications
for CHAC2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CHAC2 gene integrated from 9 sources:
(articles sorted by number of sources associating them with CHAC2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- A census of human soluble protein complexes. (PubMed id 22939629)1 Havugimana P.C....Emili A. (2012)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- Mass spectrometric analysis of lysine ubiquitylation r eveals promiscuity at site level. (PubMed id 21139048)1 Danielsen J.M....Nielsen M.L. (2011)
- hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (2007)
- Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)2 Hillier L.W....Wilson R.K. (2005)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
|
External Searches for CHAC2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CHAC2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CHAC2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CHAC2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CHAC2 | Pharmacogenomics, SNPs, Pathways |
|
| | |
About This Section
| Patent Information for CHAC2 gene:
Search GeneIP for patents involving CHAC2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CHAC2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CHAC2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CHAC2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CHAC2 | | | OriGene Protein Over-expression Lysate for CHAC2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CHAC2 | | OriGene 3'-UTR Clone for CHAC2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CHAC2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CHAC2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | OriGene Purified Protein for CHAC2 | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CHAC2 | | OriGene Custom Protein Services for CHAC2 | | | OriGene Custom Immunoassay Development | | |
| |
 |
 |
| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CHAC2 | | | Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CHAC2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CHAC2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CHAC2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CHAC2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CHAC2 |
| |
 |  |  |  | |
| | | | Search Tocris compounds for CHAC2 |
| |  |  |  |  | | | | |
 |
 |
 |
 | | | CHAC2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CHAC2 |
|  |  |  | | | | Search ThermoFisher Antibodies for CHAC2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CHAC2 |
|
|
|
|
