Aliases for CHAC1 Gene
External Ids for CHAC1 Gene
Previous GeneCards Identifiers for CHAC1 Gene
GeneCards Summary for CHAC1 Gene
CHAC1 (ChaC Glutathione-Specific Gamma-Glutamylcyclotransferase 1) is a Protein Coding gene. GO annotations related to this gene include transferase activity, transferring acyl groups and Notch binding. An important paralog of this gene is CHAC2.
UniProtKB/Swiss-Prot for CHAC1 Gene
Catalyzes the cleavage glutathione into 5-oxoproline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. Glutathione depletion is an important factor for apoptosis initiation and execution (PubMed:23070364). Acts as a pro-apoptotic component of the unfolded protein response pathway by mediating the pro-apoptotic effects of the ATF4-ATF3-DDIT3/CHOP cascade (PubMed:19109178). Negative regulator of Notch signaling pathway involved in embryonic neurogenesis: acts by inhibiting Notch cleavage by furin, maintaining Notch in an immature inactive form, thereby promoting neurogenesis in embryos (PubMed:22445366).