Aliases for CH25H Gene
External Ids for CH25H Gene
Previous GeneCards Identifiers for CH25H Gene
This is an intronless gene that is involved in cholesterol and lipid metabolism. The encoded protein is a membrane protein and contains clusters of histidine residues essential for catalytic activity. Unlike most other sterol hydroxylases, this enzyme is a member of a small family of enzymes that utilize diiron cofactors to catalyze the hydroxylation of hydrophobic substrates. [provided by RefSeq, Jul 2008]
GeneCards Summary for CH25H Gene
CH25H (Cholesterol 25-Hydroxylase) is a Protein Coding gene. Diseases associated with CH25H include alzheimer disease. Among its related pathways are Metabolism and Synthesis of bile acids and bile salts. GO annotations related to this gene include oxidoreductase activity and steroid hydroxylase activity. An important paralog of this gene is FAXDC2.
UniProtKB/Swiss-Prot for CH25H Gene
Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation.