Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CH25H Gene

protein-coding   GIFtS: 59
GCID: GC10M090955

Cholesterol 25-Hydroxylase

  See CH25H-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Cholesterol 25-Hydroxylase1 2
Cholesterol 25-Monooxygenase2 3
h25OH2 3
EC 1.14.99.383 8
C25H2

External Ids:    HGNC: 19071   Entrez Gene: 90232   Ensembl: ENSG000001381357   OMIM: 6045515   UniProtKB: O959923   

Export aliases for CH25H gene to outside databases

Previous GC identifers: GC10M089847 GC10M090187 GC10M091096 GC10M090630 GC10M084600


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CH25H Gene:
This is an intronless gene that is involved in cholesterol and lipid metabolism. The encoded protein is a membrane
protein and contains clusters of histidine residues essential for catalytic activity. Unlike most other sterol
hydroxylases, this enzyme is a member of a small family of enzymes that utilize diiron cofactors to catalyze the
hydroxylation of hydrophobic substrates. (provided by RefSeq, Jul 2008)

GeneCards Summary for CH25H Gene:
CH25H (cholesterol 25-hydroxylase) is a protein-coding gene. Diseases associated with CH25H include alzheimer's disease. GO annotations related to this gene include cholesterol 25-hydroxylase activity and iron ion binding. An important paralog of this gene is MSMO1.

UniProtKB/Swiss-Prot: CH25H_HUMAN, O95992
Function: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol
biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor
that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of
25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
RefSeq DNA sequence at NCBI GenBank:
NC_000010.10  NC_018921.2  NT_030059.14  
Regulatory elements:
   Regulatory transcription factor binding sites in the CH25H gene promoter:
         AML1a   ATF-2   POU3F1   HEN1   POU2F1   POU2F1b   POU2F1a   POU2F1c   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCH25H promoter sequence
   Search Chromatin IP Primers for CH25H

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CH25H


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23   Ensembl cytogenetic band:  10q23.31   HGNC cytogenetic band: 10q23

CH25H Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CH25H gene location

GeneLoc information about chromosome 10         GeneLoc Exon Structure

GeneLoc location for GC10M090955:  view genomic region     (about GC identifiers)

Start:
90,965,694 bp from pter      End:
90,967,071 bp from pter
Size:
1,378 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CH25H_HUMAN, O95992 (See protein sequence)
Recommended Name: Cholesterol 25-hydroxylase  
Size: 272 amino acids; 31745 Da
Cofactor: Iron
Secondary accessions: B2RBY3

Explore the universe of human proteins at neXtProt for CH25H: NX_O95992

Explore proteomics data for CH25H at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn5, Asn163, Asn189
  • Selected DME Specific Peptides for CH25H (O95992) (see all 5)
     WLSVEDH  QLLPCLG  APYFTHWDK  HRLVPFGWYGGV 


    See CH25H Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_003947.1  
    ENSEMBL proteins: 
     ENSP00000360918  
    Reactome Protein details: O95992

    CH25H Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CH25H
    OriGene Protein Over-expression Lysate for CH25H
    OriGene MassSpec for CH25H
    OriGene Custom Protein Services for CH25H
    GenScript Custom Purified and Recombinant Proteins Services for CH25H
    Novus Biologicals CH25H Proteins
    Novus Biologicals CH25H Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CH25H

     
    Search eBioscience for Proteins for CH25H 

    CH25H Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CH25H
    Novus Biologicals CH25H Antibodies
    Abcam antibodies for CH25H
    Cloud-Clone Corp. Antibodies for CH25H
    Search ThermoFisher Antibodies for CH25H
    LSBio Antibodies in human, mouse, rat for CH25H

    CH25H Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CH25H
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CH25H
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CH25H
    Cloud-Clone Corp. CLIAs for CH25H
    Search eBioscience for ELISAs for CH25H 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    HGNC Gene Families:
    FATHD: Fatty acid hydroxylase domain containing

    1 InterPro protein domain:
     IPR006694 Fatty_acid_hydroxylase

    Graphical View of Domain Structure for InterPro Entry O95992

    ProtoNet protein and cluster: O95992

    1 Blocks protein domain: IPB006088 Sterol desaturase

    UniProtKB/Swiss-Prot: CH25H_HUMAN, O95992
    Similarity: Belongs to the sterol desaturase family


    Find genes that share domains with CH25H           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CH25H_HUMAN, O95992
    Function: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol
    biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor
    that blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of
    25-hydroxycholesterol by macrophages may play a role in Leydig cell differentiation
    Catalytic activity: Cholesterol + AH(2) + O(2) = 25-hydroxycholesterol + A + H(2)O

         Genatlas biochemistry entry for CH25H:
    cholesterol 25-hydrolase,member of a small family of enzymes with diiron cofactors,potent oxysterol regulator of
    lipid metabolism

         Enzyme Number (IUBMB): EC 1.14.99.381 2

         Gene Ontology (GO): 4 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0001567cholesterol 25-hydroxylase activity IEA--
    GO:0005506iron ion binding IEA--
    GO:0008395steroid hydroxylase activity TAS--
    GO:0016491oxidoreductase activity ----
         
    Find genes that share ontologies with CH25H           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CH25H:
     Decreased viability of wild-ty 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ch25h):
     hematopoietic system  immune system 

    Find genes that share phenotypes with CH25H           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Ch25htm1Rus for CH25H

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CH25H
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CH25H

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CH25H
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CH25H

    miRNA
    Products:
        
    miRTarBase miRNAs that target CH25H:
    hsa-mir-26b-5p (MIRT029826)

    Block miRNA regulation of human, mouse, rat CH25H using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CH25H:
    hsa-miR-10b* hsa-miR-1283 hsa-miR-1303 hsa-miR-3143 hsa-miR-338-3p
    SwitchGear 3'UTR luciferase reporter plasmidCH25H 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CH25H
    Predesigned siRNA for gene silencing in human, mouse, rat CH25H

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CH25H

    Clone
    Products:
         
    OriGene clones in human, mouse for CH25H (see all 5)
    OriGene ORF clones in mouse, rat for CH25H
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CH25H (NM_003956)
    Sino Biological Human cDNA Clone for CH25H
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CH25H
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CH25H

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CH25H
    Browse ESI BIO Cell Lines and PureStem Progenitors for CH25H 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CH25H


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CH25H_HUMAN, O95992: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum5
    cytosol4
    plasma membrane3
    nucleus1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005789endoplasmic reticulum membrane IEA--
    GO:0005829cytosol TAS--
    GO:0016021integral component of membrane IEA--

    Find genes that share ontologies with CH25H           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CH25H About    
    See pathways by source

    SuperPathContained pathways About
    1Synthesis of bile acids and bile salts
    Synthesis of bile acids and bile salts0.88
    Primary bile acid biosynthesis0.00
    Bile acid and bile salt metabolism0.73
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37


    Find genes that share SuperPaths with CH25H           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CH25H
        Synthesis of bile acids and bile salts


    1 Kegg Pathway  (Kegg details for CH25H):
        Primary bile acid biosynthesis

        Pathway & Disease-focused RT2 Profiler PCR Array including CH25H: 
              Cardiotoxicity in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CH25H

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CH25H (ENSP000003609184) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYP27A1ENSP000002584154STRING: ENSP00000258415
    CELENSP000003611514STRING: ENSP00000361151
    DHCR24ENSP000003603164STRING: ENSP00000360316
    LIPAENSP000003373544STRING: ENSP00000337354
    C14orf1ENSP000002563194STRING: ENSP00000256319
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006629lipid metabolic process TAS9852097
    GO:0006633fatty acid biosynthetic process IEA--
    GO:0006699bile acid biosynthetic process TAS--
    GO:0008203cholesterol metabolic process IEA--
    GO:0008206bile acid metabolic process TAS--

    Find genes that share ontologies with CH25H           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CH25H

    5 HMDB Compounds for CH25H    About this table
    CompoundSynonyms CAS #PubMed Ids
    25-Hydroxycholesterol(beta)-cholest-5-ene-3-25-diol (see all 8)2140-46-7--
    Cholesterol(+)-ent-Cholesterol (see all 39)57-88-5--
    IronArmco iron (see all 19)7439-89-6--
    OxygenOxygen (see all 5)7782-44-7--
    WaterDihydrogen oxide (see all 2)7732-18-5--

    2 Novoseek inferred chemical compound relationships for CH25H gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    25-hydroxycholesterol 80.7 2 16696936 (1)
    cholesterol 45.4 19 9852097 (4), 16157450 (2), 16696936 (2), 16909003 (2) (see all 5)



    Find genes that share compounds with CH25H           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CH25H gene: 
    NM_003956.3  

    Unigene Cluster for CH25H:

    Cholesterol 25-hydroxylase
    Hs.47357  [show with all ESTs]
    Unigene Representative Sequence: BC017843
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000371852(uc001kfz.3)
    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CH25H using miScript Target Protectors
    5 qRT-PCR Assays for microRNAs that regulate CH25H:
    hsa-miR-10b* hsa-miR-1283 hsa-miR-1303 hsa-miR-3143 hsa-miR-338-3p
    SwitchGear 3'UTR luciferase reporter plasmidCH25H 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CH25H
    Predesigned siRNA for gene silencing in human, mouse, rat CH25H
    Clone
    Products:
         
    OriGene clones in human, mouse for CH25H (see all 5)
    OriGene ORF clones in mouse, rat for CH25H
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CH25H (NM_003956)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CH25H
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CH25H
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CH25H
    OriGene qSTAR qPCR primer pairs in human, mouse for CH25H
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CH25H
      QuantiTect SYBR Green Assays in human, mouse, rat CH25H
      QuantiFast Probe-based Assays in human, mouse, rat CH25H

    Additional mRNA sequence: 

    AF059214.1 AK314865.1 BC017843.1 BC072430.1 

    3 DOTS entries:

    DT.65287277  DT.91754712  DT.104523 

    22 AceView cDNA sequences:

    BX108159 AV709483 NM_003956 BC017843 CK822146 BM312357 AU100341 AI081548 
    BI757977 BC072430 N51903 BM543807 BI757508 AF059214 AW242961 N51873 
    CD686039 N45640 BP382057 BG484561 CK001840 W01328 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CH25H expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TTTCTGCTGG
    CH25H Expression
    About this image


    CH25H expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 6) fully expand
     
     Fibroblasts
             Cardiac Fibroblasts Myocardium
             Detroit 551
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 2 entries
             Line H9 (Naive)
     
     Heart (Cardiovascular System)
             Cardiac Fibroblasts Myocardium
     
     Epidermis (Integumentary System)
             Detroit 551
     
     Endothelium (Cardiovascular System)
             Adult Endothelial Cells Blood Brain Barrier
    CH25H Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CH25H Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.47357
        Pathway & Disease-focused RT2 Profiler PCR Array including CH25H: 
              Cardiotoxicity in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CH25H
    OriGene qSTAR qPCR primer pairs in human, mouse for CH25H
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CH25H
    QuantiTect SYBR Green Assays in human, mouse, rat CH25H
    QuantiFast Probe-based Assays in human, mouse, rat CH25H
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CH25H

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CH25H gene from Selected species (see all 14)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ch25h1 , 5 cholesterol 25-hydroxylase1, 5 81.98(n)1
    78.52(a)1
      19 (29.69 cM)5
    126421  NM_009890.11  NP_034020.11 
     344737865 
    chicken
    (Gallus gallus)
    Aves CH25H1 cholesterol 25-hydroxylase 61.83(n)
    61.69(a)
      423788  NM_001277354.1  NP_001264283.1 
    lizard
    (Anolis carolinensis)
    Reptilia CH25H6
    cholesterol 25-hydroxylase
    60(a)
    1 ↔ 1
    GL343246.1(749-1498)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia LOC1004949061 cholesterol 25-hydroxylase-like protein-like 62.88(n)
    53.73(a)
      100494906  XM_002935432.2  XP_002935478.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ch25h1 cholesterol 25-hydroxylase 62.31(n)
    58.37(a)
      494109  NM_001008652.1  NP_001008652.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG111626
    --
    22(a)
    many ↔ many
    X(13570927-13571915)
    worm
    (Caenorhabditis elegans)
    Secernentea F35C8.53   -- 31(a)   X(5401092-5402850)   --
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes ERG256
    C-4 methyl sterol oxidase, catalyzes the first of ...
    24(a)
    1 → many
    VII(610564-611493) YGR060W


    ENSEMBL Gene Tree for CH25H (if available)
    TreeFam Gene Tree for CH25H (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CH25H gene
    MSMO12  FAXDC22  

    Find genes that share paralogs with CH25H           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CH25H (see all 87)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 10 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1513209541,2
    --90965281(+) CACATC/TTATCA 1 -- ds50010--------
    rs1821144301,2
    --90965336(+) GGCACA/GCCTCC 1 -- ds50010--------
    rs1406531571,2
    --90965488(+) GCGTGC/TTTTTC 1 -- ds50010--------
    rs741499291,2
    C,F--90965557(+) AACAAC/TCCCCA 1 -- ds50011Minor allele frequency- T:0.50WA 2
    rs750218851,2
    C,F--90965681(+) TGAAAC/G/TGGAAG 1 -- ds50013WA NA 240
    rs38026581,2
    C,F,A,H--90965691(-) TAAGTA/GTTGAC 1 -- ds5001 ese318Minor allele frequency- G:0.33NS EA NA 2118
    rs412841141,2
    C--90965697(+) ACTTAT/CTTGAT 1 -- ut311Minor allele frequency- C:0.01NA 120
    rs38026571,2
    C,F,A--90965708(-) AAAAAC/ACATGA 1 -- ut317Minor allele frequency- A:0.39NA EA 374
    rs122438901,2
    C,F--90965709(+) CATGGT/GTTTTT 1 -- ut31 trp31Minor allele frequency- G:0.03WA 118
    rs40779981,2
    C,F,H--90965827(+) TTGATT/GGCTTT 1 -- ut3117Minor allele frequency- G:0.06NS EA NA WA CSA 1667

    HapMap Linkage Disequilibrium report for CH25H (90965694 - 90967071 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 5 variations for CH25H:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv517170CNV Loss19592680
    nsv437127CNV Loss16327808
    dgv118n27CNV Loss19166990
    nsv831944CNV Gain17160897
    dgv317e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CH25H
    DNA2.0 Custom Variant and Variant Library Synthesis for CH25H

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 604551    OMIM disorders: --

    1 disease for CH25H:    
    About MalaCards
    alzheimer's disease


    Find genes that share disorders with CH25H           About GenesLikeMe

    1 Novoseek inferred disease relationship for CH25H gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    alzheimers disease 39.7 2 16157450 (1), 16909003 (1)

    Genetic Association Database (GAD): CH25H
    Human Genome Epidemiology (HuGE) Navigator: CH25H (10 documents)

    Export disorders for CH25H gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CH25H gene, integrated from 10 sources (see all 19):
    (articles sorted by number of sources associating them with CH25H)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease. (PubMed id 16157450)1, 2, 4, 9 Shibata N.... Rogaeva E. (Neurosci. Lett. 2006)
    2. cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism. (PubMed id 9852097)1, 2, 3, 9 Lund E.G.... Russell D.W. (J. Biol. Chem. 1998)
    3. Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer's disease. (PubMed id 15465627)1, 2, 4, 9 Riemenschneider M.... Kurz A. (Neurobiol. Aging 2004)
    4. Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease. (PubMed id 16909003)1, 4, 9 Papassotiropoulos A....Nitsch R.M. (Neurodegener Dis 2005)
    5. Systematic analysis of candidate genes for Alzheimer's disease in a French, genome-wide association study. (PubMed id 20413850)1, 4 Laumet G....Lambert J.C. (J. Alzheimers Dis. 2010)
    6. Capillary cerebral amyloid angiopathy identifies a distinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease. (PubMed id 20535486)1, 4 Thal D.R....Ghebremedhin E. (Acta Neuropathol. 2010)
    7. Intermediate phenotypes identify divergent pathways to Alzheimer's disease. (PubMed id 20574532)1, 4 Shulman J.M....De Jager P.L. (PLoS ONE 2010)
    8. Association of CR1, CLU and PICALM with Alzheimer's disease in a cohort of clinically characterized and neuropathologically verified individuals. (PubMed id 20534741)1, 4 Corneveaux J.J....Huentelman M.J. (Hum. Mol. Genet. 2010)
    9. Assessment of Alzheimer's disease case-control associations using family-based methods. (PubMed id 18830724)1, 4 Schjeide B.M....Bertram L. (Neurogenetics 2009)
    10. Association studies of 23 positional/functional candidate genes on chromosome 10 in late-onset Alzheimer's disease. (PubMed id 17373700)1, 4 Morgan A.R....Williams J. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 9023 HGNC: 1907 AceView: CH25H Ensembl:ENSG00000138135 euGenes: HUgn9023
    ECgene: CH25H Kegg: 9023 H-InvDB: CH25H

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CH25H Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CH25H gene:
    Search GeneIP for patents involving CH25H

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CH25H  
     OriGene qPCR primer pairs and template standards for CH25H   OriGene Protein Over-expression Lysate for CH25H  
     OriGene MassSpec something-or-other for CH25H   OriGene clones in human, mouse for CH25H  
     OriGene qSTAR qPCR primer pairs in human, mouse for CH25H   OriGene Purified Protein for CH25H  
     OriGene ORF clones in mouse, rat for CH25H   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CH25H   OriGene Custom Protein Services for CH25H  

     
     
     Block miRNA regulation of human, mouse, rat CH25H using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CH25H
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CH25H Predesigned siRNA for gene silencing in human, mouse, rat CH25H
     QuantiFast Probe-based Assays in human, mouse, rat CH25H QuantiTect SYBR Green Assays in human, mouse, rat CH25H
     PCR Arrays including human, mouse, rat CH25H Search Chromatin IP Primers for CH25H
     Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CH25H  GeneGlobe Interaction Network for CH25H
     Regulatory tfbs in CH25H promoter
     GenScript Custom Purified and Recombinant Proteins Services for CH25H GenScript cDNA clones with any tag delivered in your preferred vector for CH25H
     GenScript Custom Assay Services for CH25H GenScript Custom overexpressing Cell Line Services for CH25H
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CH25H
     Browse Sino Biological Proteins
     Browse Sino Biological Cell Lysates
     cDNA Clones for CH25H
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CH25H antibodies
     CH25H proteins
     CH25H lysates
     Antibodies for CH25H
     See all of Abcam's Antibodies, Kits and Proteins for CH25H
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Proteins for CH25H
     Antibodies for CH25H
     ELISAs for CH25H
     CLIAs for CH25H



     Browse ESI BIO Cell Lines and PureStem Progenitors for CH25H
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CH25H
     SwitchGear 3'UTR luciferase reporter plasmids for CH25H
     SwitchGear Promoter luciferase reporter plasmids for CH25H
     Search ThermoFisher Antibodies for CH25H
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CH25H
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CH25H
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CH25H
     LSBio Antibodies in human, mouse, rat for CH25H
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CH25H
      Search eBioscience for proteins for CH25H
      Search eBioscience for elisas for CH25H
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CH25H gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4