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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CH25H Gene

protein-coding GIFtS: 57
GCID: GC10M090955

cholesterol 25-hydroxylase

Explore 5 diseases affiliated with
CH25H via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cholesterol 25-Hydroxylase¹ ²
Cholesterol 25-Monooxygenase² ³
H25OH¹
EC 1.14.99.38³ ⁸
C25H²

External Ids:	HGNC: 1907¹	Entrez Gene: 9023²	Ensembl: ENSG00000138135⁷	OMIM: 604551⁵	UniProtKB: O95992³

Export aliases for CH25H gene to outside databases

Previous GC identifers: GC10M089847 GC10M090187 GC10M091096 GC10M090630 GC10M084600

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CH25H:

This is an intronless gene that is involved in cholesterol and lipid metabolism. The encoded protein is a membrane

protein and contains clusters of histidine residues essential for catalytic activity. Unlike most other sterol

hydroxylases, this enzyme is a member of a small family of enzymes that utilize diiron cofactors to catalyze the

hydroxylation of hydrophobic substrates. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CH25H_HUMAN, O95992

Function: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol

biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that

blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by

macrophages may play a role in Leydig cell differentiation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000010.10 NC_018921.1 NT_030059.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CH25H gene promoter:
AML1a ATF-2 POU3F1 HEN1 POU2F1 POU2F1b POU2F1a POU2F1c c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CH25H promoter sequence

Search SABiosciences Chromatin IP Primers for CH25H

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CH25H

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 10q23 Ensembl cytogenetic band: 10q23.31 HGNC cytogenetic band: 10q23

CH25H Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CH25H gene location

GeneLoc information about chromosome 10 GeneLoc Exon Structure

GeneLoc location for GC10M090955: view genomic region (about GC identifiers)

Start:	90,965,694 bp from pter	End:	90,967,071 bp from pter
Size:	1,378 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CH25H_HUMAN, O95992 (See protein sequence)

Recommended Name: Cholesterol 25-hydroxylase

Size: 272 amino acids; 31745 Da

Cofactor: Iron

Subcellular location: Endoplasmic reticulum membrane; Multi-pass membrane protein (By similarity)

Secondary accessions: B2RBY3

Explore the universe of human proteins at neXtProt for CH25H: NX_O95992

Post-translational modifications:

N-glycosylated¹

View neXtProt modification sites for NX_O95992

4/5 DME Specific Peptides for CH25H (O95992) (see all 5)

WLSVEDH

QLLPCLG

APYFTHWDK

HRLVPFGWYGGV

CH25H Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_003947.1

ENSEMBL proteins:

ENSP00000360918

Reactome Protein details: O95992
Human Recombinant Protein Products for CH25H:

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	Uscn Proteins for CH25H

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005789	endoplasmic reticulum membrane	IEA	--
GO:0005829	cytosol	TAS	--
GO:0016021	integral to membrane	IEA	--

CH25H for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CH25H

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CH25H for domains About GeneDecksing

1 InterPro domain/family:

IPR006694 Fatty_acid_hydroxylase

Graphical View of Domain Structure for InterPro Entry O95992

ProtoNet protein and cluster: O95992

1 Blocks protein family: IPB006088 Sterol desaturase

UniProtKB/Swiss-Prot: CH25H_HUMAN, O95992

Similarity: Belongs to the sterol desaturase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CH25H_HUMAN, O95992

Function: Catalyzes the formation of 25-hydroxycholesterol from cholesterol, leading to repress cholesterol

biosynthetic enzymes. May play an important role in regulating lipid metabolism by synthesizing a corepressor that

blocks sterol regulatory element binding protein (SREBP) processing. In testis, production of 25-hydroxycholesterol by

macrophages may play a role in Leydig cell differentiation

Catalytic activity: Cholesterol + AH(2) + O(2) = 25-hydroxycholesterol + A + H(2)O

Genatlas biochemistry entry for CH25H:

cholesterol 25-hydrolase,member of a small family of enzymes with diiron cofactors,potent oxysterol regulator of lipid

metabolism

Enzyme Number (IUBMB): EC 1.14.99.38¹ ²

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0001567	cholesterol 25-hydroxylase activity	IEA	--
GO:0005506	iron ion binding	IEA	--
GO:0008395	steroid hydroxylase activity	TAS	--

CH25H for ontologies About GeneDecksing

Phenotypes:
1 GenomeRNAi human phenotype for CH25H:

Decreased viability of wild-ty

1 MGI mutant phenotype (inferred from 1 allele) (MGI details for Ch25h):

immune system

CH25H for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Ch25h^tm1Rus for CH25H

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CH25H

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CH25H
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate CH25H:
		hsa-miR-10b* hsa-miR-1283 hsa-miR-1303 hsa-miR-3143 hsa-miR-338-3p
		SwitchGear 3'UTR luciferase reporter plasmid: CH25H 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CH25H (see all 7) OriGene shRNA RFP: CH25H OriGene siRNA: CH25H
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		Sirion Biotech Custom design and validation of potent shRNA sequences against CH25H

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CH25H

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Synthesis of bile acids and bile salts

	Synthesis of bile acids and bile salts	1.00			Bile acid and bile salt metabolism	0.70
	Primary bile acid biosynthesis	0.84

Metabolism

Metabolism

1.00

Metabolism of lipids and lipoproteins

0.34

Pathway sources
See GeneCards unified pathways
Show all pathways

4 Reactome Pathways for CH25H

	Bile acid and bile salt metabolism
	Metabolism
	Synthesis of bile acids and bile salts
	Metabolism of lipids and lipoproteins

1 Kegg Pathway (Kegg details for CH25H):

Primary bile acid biosynthesis

CH25H for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CH25H

STRING Interaction Network Preview (showing 5 interactants - click image to see 14)

5/14 Interacting proteins for CH25H (ENSP00000360918⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 14)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CYP27A1	ENSP00000258415⁴	STRING: ENSP00000258415
CYP46A1	ENSP00000261835⁴	STRING: ENSP00000261835
CYP7A1	ENSP00000301645⁴	STRING: ENSP00000301645
CYP7B1	ENSP00000310721⁴	STRING: ENSP00000310721
CEL	ENSP00000361151⁴	STRING: ENSP00000361151

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006629	lipid metabolic process	TAS	9852097
GO:0006633	fatty acid biosynthetic process	IEA	--
GO:0006699	bile acid biosynthetic process	TAS	--
GO:0008203	cholesterol metabolic process	IEA	--
GO:0008206	bile acid metabolic process	TAS	--

CH25H for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CH25H for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CH25H

5 HMDB Compounds for CH25H About this table

Compound	Synonyms	CAS #	PubMed Ids
25-Hydroxycholesterol	(beta)-cholest-5-ene-3-25-diol (see all 8)	2140-46-7	--
Cholesterol	(+)-ent-Cholesterol (see all 39)	57-88-5	--
Iron	Armco iron (see all 19)	7439-89-6	--
Oxygen	Oxygen (see all 5)	7782-44-7	--
Water	Dihydrogen oxide (see all 2)	7732-18-5	--

2 Novoseek chemical compound relationships for CH25H gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
25-hydroxycholesterol	80.7	2	16696936 (1)
cholesterol	45.4	19	9852097 (4), 16157450 (2), 16696936 (2), 16909003 (2) (see all 5)

Search CenterWatch for drugs/clinical trials and news about CH25H

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CH25H gene:

NM_003956.3

Unigene Cluster for CH25H:

Cholesterol 25-hydroxylase

Hs.47357 [show with all ESTs]

Unigene Representative Sequence: BC017843

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000371852(uc001kfz.3)

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CH25H
		5 QIAGEN miScript miRNA Assays for microRNAs that regulate CH25H:
		hsa-miR-10b* hsa-miR-1283 hsa-miR-1303 hsa-miR-3143 hsa-miR-338-3p
		SwitchGear 3'UTR luciferase reporter plasmid: CH25H 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
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		GenScript: all cDNA clones in your preferred vector: CH25H (NM_003956)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CH25H
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CH25H
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CH25H

Additional cDNA sequence:

AF059214.1 AK314865.1 BC017843.1 BC072430.1

3 DOTS entries:

DT.65287277 DT.91754712 DT.104523

22 AceView cDNA sequences:

NM_003956 BX108159 BC017843 AV709483 BM543807 AU100341 BC072430 BI757977

CK822146 AW242961 BM312357 N51903 BI757508 AI081548 AF059214 N51873

CD686039 N45640 BP382057 BG484561 W01328 CK001840

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CH25H expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TTTCTGCTGG

About this image

CH25H expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Blood Brain Barrier

Adult Endothelial Cells

Blood Brain Barrier, Endothelium

Heart

Myocardium

Cardiac Fibroblasts

Epicardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CH25H Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CH25H

SOURCE GeneReport for Unigene cluster: Hs.47357

SABiosciences Expression via Pathway-Focused PCR Array including CH25H:

Cardiotoxicity in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CH25H

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CH25H gene from 6/15 species (see all 15) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CH25H¹	cholesterol 25-hydroxylase	61.94(n) 61.94(a)		423788 XM_421660.3 XP_421660.2
lizard (Anolis carolinensis)	Reptilia	CH25H⁶	--	60(a)	1 ↔ 1	GL343246.1(749-1498)
zebrafish (Danio rerio)	Actinopterygii	ch25h¹	cholesterol 25-hydroxylase	62.31(n) 58.37(a)		494109 NM_001008652.1 NP_001008652.1
worm (Caenorhabditis elegans)	Secernentea	F35C8.5³	--	31(a)		X(5401092-5402850) --
thale cress (Arabidopsis thaliana)	eudicotyledons	SBH2⁶ SBH1⁶	sphingoid base hydroxylase 1	19(a) 18(a)	1 ↔ many 1 ↔ many	1(4880051-4881964) 1(26193659-26195695)
rice (Oryza sativa)	Liliopsida	-- DSH1⁶ (see all 5)	sphingolipid C4-hydroxylase SUR2, putative, expres... sphingolipid C4-hydroxylase SUR2, putative, expres... (see all 5)	20(a) 19(a) (see all 5)	1 ↔ many 1 ↔ many (see all 5)	2(31293702-31296089) 6(6588793-6590800)

ENSEMBL Gene Tree for CH25H (if available)
TreeFam Gene Tree for CH25H (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CH25H gene

MSMO1² C5orf4²

CH25H for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 10 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs151320954^1,2		--	90965281(+)	`CACATC/TTATCA`	1	--	ds500¹		0	--	--	--	--
rs182114430^1,2		--	90965336(+)	`GGCACA/GCCTCC`	1	--	ds500¹		0	--	--	--	--
rs140653157^1,2		--	90965488(+)	`GCGTGC/TTTTTC`	1	--	ds500¹		0	--	--	--	--
rs74149929^1,2	C	--	90965557(+)	`AACAAC/TCCCCA`	1	--	ds500¹		1		WA	2
rs75021885^1,2	C	--	90965681(+)	`TGAAAC/G/TGGAAG`	1	--	ds500¹		3		WA NA	240
rs3802658^1,2	C,F,A,H	--	90965691(-)	`TAAGTA/GTTGAC`	1	--	ds500¹ ese³		18		NS EA NA	2118
rs41284114^1,2	C	--	90965697(+)	`ACTTAT/CTTGAT`	1	--	ut3¹		1		NA	120
rs3802657^1,2	C,F,A	--	90965708(-)	`AAAAAC/ACATGA`	1	--	ut3¹		7		NA EA	374
rs12243890^1,2	F	--	90965709(+)	`CATGGT/GTTTTT`	1	--	ut3¹ trp³		1		WA	118
rs4077998^1,2	C,F,H	--	90965827(+)	`TTGATT/GGCTTT`	1	--	ut3¹		17		NS EA NA WA CSA	1667

HapMap Linkage Disequilibrium report for CH25H (90965694 - 90967071 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CH25H
3 CNVs: 3816 53302 4708

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CH25H

DNA2.0 Custom Variant and Variant Library Synthesis for CH25H

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CH25H for disorders           About GeneDecksing

OMIM gene information: 604551    OMIM disorders: --

5 diseases for CH25H:    About MalaCards

cholesterol cerebral amyloid angiopathy alzheimer's disease cerebritis

prostatitis

1 Novoseek disease relationship for CH25H gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
alzheimers disease	39.7	2	16157450 (1), 16909003 (1)

Genetic Association Database (GAD): CH25H
Human Genome Epidemiology (HuGE) Navigator: CH25H (10 documents)

Export disorders for CH25H gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CH25H gene, integrated from 9 sources (see all 19):
(articles sorted by number of sources associating them with CH25H)

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Association studies of cholesterol metabolism genes (CH25H, ABCA1 and CH24H) in Alzheimer's disease. (PubMed id 16157450)^{1, 2, 4, 9} Shibata N.... Rogaeva E. (2006)
cDNA cloning of mouse and human cholesterol 25-hydroxylases, polytopic membrane proteins that synthesize a potent oxysterol regulator of lipid metabolism. (PubMed id 9852097)^{1, 2, 3, 9} Lund E.G.... Russell D.W. (1998)
Association analysis of genes involved in cholesterol metabolism located within the linkage region on chromosome 10 and Alzheimer's disease. (PubMed id 15465627)^{1, 2, 4, 9} Riemenschneider M.... Kurz A. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The DNA sequence and comparative analysis of human chromosome 10. (PubMed id 15164054)^{1, 2} Deloukas P.... Rogers J. (2004)
Cholesterol 25-hydroxylase on chromosome 10q is a susceptibility gene for sporadic Alzheimer's disease. (PubMed id 16909003)^{1, 9} Papassotiropoulos A....Nitsch R.M. (2005)
Systematic analysis of candidate genes for Alzheimer' s disease in a French, genome-wide association study. (PubMed id 20413850)¹ Laumet G....Lambert J.C. (2010)
Identification of genomic predictors of atrioventricu lar conduction: using electronic medical records as a tool for genome science. (PubMed id 21041692)¹ Denny J.C....Roden D.M. (2010)
Intermediate phenotypes identify divergent pathways t o Alzheimer's disease. (PubMed id 20574532)¹ Shulman J.M....De Jager P.L. (2010)
Capillary cerebral amyloid angiopathy identifies a di stinct APOE epsilon4-associated subtype of sporadic Alzheimer's disease. (PubMed id 20535486)¹ Thal D.R....Ghebremedhin E. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 9023	HGNC: 1907	AceView: CH25H	Ensembl:ENSG00000138135	euGenes: HUgn9023
ECgene: CH25H	Kegg: 9023	H-InvDB: CH25H

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CH25H	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CH25H gene
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Patent Information for CH25H gene:
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cholesterol 25-hydroxylase

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cholesterol 25-hydroxylase

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