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Aliases for CGRRF1 Gene

Aliases for CGRRF1 Gene

  • Cell Growth Regulator With Ring Finger Domain 1 2 3 5
  • Cell Growth Regulatory Gene 19 Protein 3 4
  • RING Finger Protein 197 3 4
  • RNF197 3 4
  • CGR19 3 4
  • Cell Growth Regulator With RING Finger Domain Protein 1 3

External Ids for CGRRF1 Gene

Previous GeneCards Identifiers for CGRRF1 Gene

  • GC14P052966
  • GC14P054046
  • GC14P054976
  • GC14P035139

Summaries for CGRRF1 Gene

GeneCards Summary for CGRRF1 Gene

CGRRF1 (Cell Growth Regulator With Ring Finger Domain 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CGRRF1 Gene

  • Able to inhibit growth in several cell lines.

Additional gene information for CGRRF1 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGRRF1 Gene

Genomics for CGRRF1 Gene

Regulatory Elements for CGRRF1 Gene

Enhancers for CGRRF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH14H054648 1.5 Ensembl ENCODE dbSUPER 9.9 +142.1 142087 7 FOXA2 ARID4B SIN3A FOS ATF7 SP5 REST PPARG NFIL3 MIER3 CGRRF1 SAMD4A LOC729451
GH14H054642 1.3 Ensembl ENCODE dbSUPER 10.8 +133.6 133620 2 ELF3 SOX13 TBP CTCF TFAP4 FOXA2 SAP130 ARID4B CEBPG RAD21 SAMD4A CGRRF1 LOC729451
GH14H054487 1.1 ENCODE 11.8 -20.4 -20374 3 HDGF PKNOX1 ARID4B SIN3A YBX1 DMAP1 ZNF2 YY1 ZNF143 ZNF207 ATG14 BMP4 MAPK1IP1L SOCS4 ENSG00000259318 ENSG00000258753 ATP5C1P1 RPL34P28 COX5AP1 ENSG00000258050
GH14H054664 1.2 Ensembl ENCODE dbSUPER 10.7 +158.6 158574 8 STAT1 NR3C1 BATF ZNF664 JUND GATA3 POLR2A SCRT2 FOS PRDM10 SAMD4A CGRRF1 LOC729451
GH14H054482 1.1 Ensembl ENCODE 10.9 -26.4 -26361 1 FOXA2 RAD21 RARA YY1 MIXL1 PPARG ZNF592 NFIL3 RCOR2 HNF4A CGRRF1 GMFB ENSG00000258753
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CGRRF1 on UCSC Golden Path with GeneCards custom track

Promoters for CGRRF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000068704 189 1600 HDGF FOXA2 PKNOX1 ARID4B SIN3A DMAP1 YY1 ZNF143 SP3 SP5

Genomic Location for CGRRF1 Gene

Chromosome:
14
Start:
54,509,812 bp from pter
End:
54,539,309 bp from pter
Size:
29,498 bases
Orientation:
Plus strand

Genomic View for CGRRF1 Gene

Genes around CGRRF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGRRF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGRRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGRRF1 Gene

Proteins for CGRRF1 Gene

  • Protein details for CGRRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99675-CGRF1_HUMAN
    Recommended name:
    Cell growth regulator with RING finger domain protein 1
    Protein Accession:
    Q99675
    Secondary Accessions:
    • Q96BX2

    Protein attributes for CGRRF1 Gene

    Size:
    332 amino acids
    Molecular mass:
    38242 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CGRRF1 Gene

neXtProt entry for CGRRF1 Gene

Post-translational modifications for CGRRF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CGRRF1 Gene

No data available for DME Specific Peptides for CGRRF1 Gene

Domains & Families for CGRRF1 Gene

Gene Families for CGRRF1 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins
  • Predicted membrane proteins

Protein Domains for CGRRF1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CGRRF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CGRRF1: view

No data available for UniProtKB/Swiss-Prot for CGRRF1 Gene

Function for CGRRF1 Gene

Molecular function for CGRRF1 Gene

UniProtKB/Swiss-Prot Function:
Able to inhibit growth in several cell lines.

Phenotypes From GWAS Catalog for CGRRF1 Gene

Gene Ontology (GO) - Molecular Function for CGRRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CGRRF1: view
genes like me logo Genes that share phenotypes with CGRRF1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CGRRF1

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CGRRF1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CGRRF1 Gene

Localization for CGRRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGRRF1 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CGRRF1 gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 2
endoplasmic reticulum 1
lysosome 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Nucleoplasm (3)
  • Vesicles (2)
See all subcellular structures

Gene Ontology (GO) - Cellular Components for CGRRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm IDA --
GO:0016020 membrane IEA --
GO:0016021 integral component of membrane IEA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with CGRRF1: view

Pathways & Interactions for CGRRF1 Gene

SuperPathways for CGRRF1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CGRRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress TAS 8968090
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest IEA --
GO:0008285 negative regulation of cell proliferation TAS 8968090
genes like me logo Genes that share ontologies with CGRRF1: view

No data available for Pathways by source and SIGNOR curated interactions for CGRRF1 Gene

Drugs & Compounds for CGRRF1 Gene

No Compound Related Data Available

Transcripts for CGRRF1 Gene

Unigene Clusters for CGRRF1 Gene

Cell growth regulator with ring finger domain 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CGRRF1
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CGRRF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c · 11d
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - -
SP10: - - - -
SP11: - - - - - -
SP12: - -
SP13:
SP14:

Relevant External Links for CGRRF1 Gene

GeneLoc Exon Structure for
CGRRF1
ECgene alternative splicing isoforms for
CGRRF1

Expression for CGRRF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CGRRF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

NURSA nuclear receptor signaling pathways regulating expression of CGRRF1 Gene:

CGRRF1

SOURCE GeneReport for Unigene cluster for CGRRF1 Gene:

Hs.59106

Evidence on tissue expression from TISSUES for CGRRF1 Gene

  • Nervous system(4.4)
  • Muscle(4.2)
genes like me logo Genes that share expression patterns with CGRRF1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CGRRF1 Gene

Orthologs for CGRRF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGRRF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CGRRF1 33 34
  • 99.9 (n)
cow
(Bos Taurus)
Mammalia CGRRF1 33 34
  • 93.78 (n)
dog
(Canis familiaris)
Mammalia CGRRF1 33 34
  • 93.07 (n)
mouse
(Mus musculus)
Mammalia Cgrrf1 33 16 34
  • 84.4 (n)
rat
(Rattus norvegicus)
Mammalia Cgrrf1 33
  • 82.87 (n)
oppossum
(Monodelphis domestica)
Mammalia CGRRF1 34
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CGRRF1 34
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves CGRRF1 33 34
  • 77.44 (n)
lizard
(Anolis carolinensis)
Reptilia CGRRF1 34
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cgrrf1 33
  • 69.54 (n)
zebrafish
(Danio rerio)
Actinopterygii cgrrf1 33 34
  • 56.98 (n)
Species where no ortholog for CGRRF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGRRF1 Gene

ENSEMBL:
Gene Tree for CGRRF1 (if available)
TreeFam:
Gene Tree for CGRRF1 (if available)

Paralogs for CGRRF1 Gene

(6) SIMAP similar genes for CGRRF1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CGRRF1: view

No data available for Paralogs for CGRRF1 Gene

Variants for CGRRF1 Gene

Sequence variations from dbSNP and Humsavar for CGRRF1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs1000008891 -- 54,521,219(+) ACTTT(G/T)GGAGG intron-variant
rs1000216724 -- 54,514,836(+) AATTT(A/C)CCTTT intron-variant
rs1000299173 -- 54,527,369(+) TGACG(A/T)GTTAA intron-variant
rs1000467493 -- 54,535,684(+) TTTGT(C/G)CTAGA intron-variant
rs1000487878 -- 54,509,278(+) ATAAG(C/G)AATGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CGRRF1 Gene

Variant ID Type Subtype PubMed ID
esv3551581 CNV deletion 23714750
nsv832802 CNV loss 17160897

Variation tolerance for CGRRF1 Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 61.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CGRRF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CGRRF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGRRF1 Gene

Disorders for CGRRF1 Gene

Relevant External Links for CGRRF1

Genetic Association Database (GAD)
CGRRF1
Human Genome Epidemiology (HuGE) Navigator
CGRRF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CGRRF1

No disorders were found for CGRRF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CGRRF1 Gene

Publications for CGRRF1 Gene

  1. Induction of cell growth regulatory genes by p53. (PMID: 8968090) Madden SL … Beaudry GA (Cancer research 1996) 2 3 4 60
  2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M … Tokunaga K (Human genetics 2010) 3 45 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. Architecture of the human interactome defines protein communities and disease networks. (PMID: 28514442) Huttlin EL … Harper JW (Nature 2017) 3 60
  5. Defining the Protein-Protein Interaction Network of the Human Protein Tyrosine Phosphatase Family. (PMID: 27432908) Li X … Wang W (Molecular & cellular proteomics : MCP 2016) 3 60

Products for CGRRF1 Gene

Sources for CGRRF1 Gene

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