Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CGRRF1 Gene

Aliases for CGRRF1 Gene

  • Cell Growth Regulator With Ring Finger Domain 1 2 3
  • CGR19 3 4 6
  • Cell Growth Regulatory Gene 19 Protein 3 4
  • RING Finger Protein 197 3 4
  • RNF197 3 4
  • Cell Growth Regulator With RING Finger Domain Protein 1 3
  • GCRRF1 6

External Ids for CGRRF1 Gene

Summaries for CGRRF1 Gene

GeneCards Summary for CGRRF1 Gene

CGRRF1 (Cell Growth Regulator With Ring Finger Domain 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CGRRF1 Gene

  • Able to inhibit growth in several cell lines.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGRRF1 Gene

Genomics for CGRRF1 Gene

Genomic Location for CGRRF1 Gene

Start:
54,509,812 bp from pter
End:
54,539,309 bp from pter
Size:
29,498 bases
Orientation:
Plus strand

Genomic View for CGRRF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CGRRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGRRF1 Gene

Regulatory Elements for CGRRF1 Gene

Proteins for CGRRF1 Gene

  • Protein details for CGRRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99675-CGRF1_HUMAN
    Recommended name:
    Cell growth regulator with RING finger domain protein 1
    Protein Accession:
    Q99675
    Secondary Accessions:
    • Q96BX2

    Protein attributes for CGRRF1 Gene

    Size:
    332 amino acids
    Molecular mass:
    38242 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CGRRF1 Gene

neXtProt entry for CGRRF1 Gene

Proteomics data for CGRRF1 Gene at MOPED

Post-translational modifications for CGRRF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CGRRF1 Gene

No data available for DME Specific Peptides for CGRRF1 Gene

Domains for CGRRF1 Gene

Gene Families for CGRRF1 Gene

HGNC:
  • RNF :RING-type (C3HC4) zinc fingers

Protein Domains for CGRRF1 Gene

InterPro:
Blocks:
ProtoNet:

UniProtKB/Swiss-Prot:

CGRF1_HUMAN
Similarity:
  • Contains 1 RING-type zinc finger.:
    • Q99675
genes like me logo Genes that share domains with CGRRF1: view

Function for CGRRF1 Gene

Molecular function for CGRRF1 Gene

UniProtKB/Swiss-Prot Function: Able to inhibit growth in several cell lines.

Gene Ontology (GO) - Molecular Function for CGRRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
GO:0008270 zinc ion binding IEA --
genes like me logo Genes that share ontologies with CGRRF1: view

Phenotypes for CGRRF1 Gene

GenomeRNAi human phenotypes for CGRRF1:
genes like me logo Genes that share phenotypes with CGRRF1: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CGRRF1 Gene

Localization for CGRRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGRRF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CGRRF1 Gene COMPARTMENTS Subcellular localization image for CGRRF1 gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 2
endoplasmic reticulum 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CGRRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus --
GO:0005654 nucleoplasm IDA --
GO:0043231 intracellular membrane-bounded organelle IDA --
genes like me logo Genes that share ontologies with CGRRF1: view

Pathways for CGRRF1 Gene

SuperPathways for CGRRF1 Gene

No Data Available

Interacting Proteins for CGRRF1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000216420%0d%0a9606.ENSP00000288774%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000360116%0d%0a
Selected Interacting proteins: ENSP00000216420 Q99675-CGRF1_HUMAN for CGRRF1 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CGRRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress TAS 8968090
GO:0007050 cell cycle arrest IEA --
GO:0008285 negative regulation of cell proliferation TAS 8968090
genes like me logo Genes that share ontologies with CGRRF1: view

No data available for Pathways by source for CGRRF1 Gene

Transcripts for CGRRF1 Gene

Unigene Clusters for CGRRF1 Gene

Cell growth regulator with ring finger domain 1:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CGRRF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c · 11d
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - -
SP10: - - - -
SP11: - - - - - -
SP12: - -
SP13:
SP14:

Relevant External Links for CGRRF1 Gene

GeneLoc Exon Structure for
CGRRF1
ECgene alternative splicing isoforms for
CGRRF1

Expression for CGRRF1 Gene

mRNA expression in normal human tissues for CGRRF1 Gene

SOURCE GeneReport for Unigene cluster for CGRRF1 Gene Hs.59106

genes like me logo Genes that share expressions with CGRRF1: view

Orthologs for CGRRF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGRRF1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CGRRF1 36
  • 99.9 (n)
  • 99.7 (a)
CGRRF1 37
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CGRRF1 36
  • 93.78 (n)
  • 96.39 (a)
CGRRF1 37
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CGRRF1 36
  • 93.07 (n)
  • 93.98 (a)
CGRRF1 37
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cgrrf1 36
  • 84.4 (n)
  • 84.71 (a)
Cgrrf1 16
Cgrrf1 37
  • 84 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CGRRF1 37
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CGRRF1 37
  • 64 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cgrrf1 36
  • 82.87 (n)
  • 84.71 (a)
chicken
(Gallus gallus)
Aves CGRRF1 36
  • 77.44 (n)
  • 79.57 (a)
CGRRF1 37
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CGRRF1 37
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cgrrf1 36
  • 69.54 (n)
  • 68.31 (a)
zebrafish
(Danio rerio)
Actinopterygii cgrrf1 36
  • 56.98 (n)
  • 51.38 (a)
cgrrf1 37
  • 50 (a)
OneToOne
Species with no ortholog for CGRRF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGRRF1 Gene

ENSEMBL:
Gene Tree for CGRRF1 (if available)
TreeFam:
Gene Tree for CGRRF1 (if available)

Paralogs for CGRRF1 Gene

Selected SIMAP similar genes for CGRRF1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CGRRF1: view

No data available for Paralogs for CGRRF1 Gene

Variants for CGRRF1 Gene

Sequence variations from dbSNP and Humsavar for CGRRF1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type MAF
rs1130012 -- 54,538,147(+) TGTTG(A/G)AAAAG missense, reference
rs1130093 -- 54,538,609(+) CTCTT(A/G)AAAAA utr-variant-3-prime
rs1954209 -- 54,516,669(-) TCAAT(A/G)AGCTC intron-variant
rs1954210 -- 54,516,539(-) GGAAA(A/G)AAAGA intron-variant
rs1959806 -- 54,535,461(-) CAGAT(A/G)TAAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CGRRF1 Gene

Variant ID Type Subtype PubMed ID
nsv832802 CNV Loss 17160897

Relevant External Links for CGRRF1 Gene

HapMap Linkage Disequilibrium report
CGRRF1

Disorders for CGRRF1 Gene

Relevant External Links for CGRRF1

Genetic Association Database (GAD)
CGRRF1
Human Genome Epidemiology (HuGE) Navigator
CGRRF1
genes like me logo Genes that share disorders with CGRRF1: view

No data available for UniProtKB/Swiss-Prot for CGRRF1 Gene

Publications for CGRRF1 Gene

  1. Induction of cell growth regulatory genes by p53. (PMID: 8968090) Madden S.L. … Beaudry G.A. (Cancer Res. 1996) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PMID: 20677014) Shimada M. … Tokunaga K. (Hum. Genet. 2010) 3 49
  4. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PMID: 21906983) Kim W. … Gygi S.P. (Mol. Cell 2011) 3
  5. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 3

Products for CGRRF1 Gene

Sources for CGRRF1 Gene

Back to Top

Content