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Aliases for CGRRF1 Gene

Aliases for CGRRF1 Gene

  • Cell Growth Regulator With Ring Finger Domain 1 2 3 5
  • Cell Growth Regulatory Gene 19 Protein 3 4
  • RING Finger Protein 197 3 4
  • RNF197 3 4
  • CGR19 3 4

External Ids for CGRRF1 Gene

Previous GeneCards Identifiers for CGRRF1 Gene

  • GC14P052966
  • GC14P054046
  • GC14P054976
  • GC14P035139

Summaries for CGRRF1 Gene

GeneCards Summary for CGRRF1 Gene

CGRRF1 (Cell Growth Regulator With Ring Finger Domain 1) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CGRRF1 Gene

  • Able to inhibit growth in several cell lines.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGRRF1 Gene

Genomics for CGRRF1 Gene

Regulatory Elements for CGRRF1 Gene

Promoters for CGRRF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CGRRF1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CGRRF1 Gene

Chromosome:
14
Start:
54,509,812 bp from pter
End:
54,539,309 bp from pter
Size:
29,498 bases
Orientation:
Plus strand

Genomic View for CGRRF1 Gene

Genes around CGRRF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGRRF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGRRF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGRRF1 Gene

Proteins for CGRRF1 Gene

  • Protein details for CGRRF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q99675-CGRF1_HUMAN
    Recommended name:
    Cell growth regulator with RING finger domain protein 1
    Protein Accession:
    Q99675
    Secondary Accessions:
    • Q96BX2

    Protein attributes for CGRRF1 Gene

    Size:
    332 amino acids
    Molecular mass:
    38242 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CGRRF1 Gene

neXtProt entry for CGRRF1 Gene

Proteomics data for CGRRF1 Gene at MOPED

Post-translational modifications for CGRRF1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CGRRF1 Gene

Antibody Products

No data available for DME Specific Peptides for CGRRF1 Gene

Domains & Families for CGRRF1 Gene

Gene Families for CGRRF1 Gene

Protein Domains for CGRRF1 Gene

InterPro:
Blocks:
ProtoNet:

Suggested Antigen Peptide Sequences for CGRRF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q99675

UniProtKB/Swiss-Prot:

CGRF1_HUMAN :
  • Contains 1 RING-type zinc finger.
Similarity:
  • Contains 1 RING-type zinc finger.
genes like me logo Genes that share domains with CGRRF1: view

Function for CGRRF1 Gene

Molecular function for CGRRF1 Gene

UniProtKB/Swiss-Prot Function:
Able to inhibit growth in several cell lines.
genes like me logo Genes that share phenotypes with CGRRF1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CGRRF1

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CGRRF1 Gene

Localization for CGRRF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGRRF1 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CGRRF1 Gene COMPARTMENTS Subcellular localization image for CGRRF1 gene
Compartment Confidence
nucleus 5
extracellular 3
plasma membrane 2
endoplasmic reticulum 1
lysosome 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CGRRF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016021 integral component of membrane IEA --
genes like me logo Genes that share ontologies with CGRRF1: view

Pathways & Interactions for CGRRF1 Gene

SuperPathways for CGRRF1 Gene

No Data Available

Interacting Proteins for CGRRF1 Gene

STRING Interaction Network Preview (showing 3 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000216420%0d%0a9606.ENSP00000288774%0d%0a9606.ENSP00000344818%0d%0a9606.ENSP00000360116%0d%0a
Selected Interacting proteins: Q99675-CGRF1_HUMAN ENSP00000216420 for CGRRF1 Gene via I2D STRING

Gene Ontology (GO) - Biological Process for CGRRF1 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CGRRF1 Gene

Drugs & Compounds for CGRRF1 Gene

No Compound Related Data Available

Transcripts for CGRRF1 Gene

Unigene Clusters for CGRRF1 Gene

Cell growth regulator with ring finger domain 1:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CGRRF1 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c · 11d
SP1: - - - - - - - - - - -
SP2: - - - - - - - -
SP3: - - - - - - - - - - - -
SP4: - - - - - - - - -
SP5: - - - - -
SP6: - - - - -
SP7: - - - - - - - - - - - - - - - -
SP8: - - - - - - - - -
SP9: - - - - - - -
SP10: - - - -
SP11: - - - - - -
SP12: - -
SP13:
SP14:

Relevant External Links for CGRRF1 Gene

GeneLoc Exon Structure for
CGRRF1
ECgene alternative splicing isoforms for
CGRRF1

Expression for CGRRF1 Gene

mRNA expression in normal human tissues for CGRRF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

SOURCE GeneReport for Unigene cluster for CGRRF1 Gene Hs.59106

genes like me logo Genes that share expression patterns with CGRRF1: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CGRRF1 Gene

Orthologs for CGRRF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGRRF1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CGRRF1 35
  • 93.78 (n)
  • 96.39 (a)
CGRRF1 36
  • 96 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CGRRF1 35
  • 93.07 (n)
  • 93.98 (a)
CGRRF1 36
  • 94 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cgrrf1 35
  • 84.4 (n)
  • 84.71 (a)
Cgrrf1 16
Cgrrf1 36
  • 84 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CGRRF1 35
  • 99.9 (n)
  • 99.7 (a)
CGRRF1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cgrrf1 35
  • 82.87 (n)
  • 84.71 (a)
oppossum
(Monodelphis domestica)
Mammalia CGRRF1 36
  • 79 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CGRRF1 36
  • 64 (a)
OneToOne
chicken
(Gallus gallus)
Aves CGRRF1 35
  • 77.44 (n)
  • 79.57 (a)
CGRRF1 36
  • 76 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CGRRF1 36
  • 75 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cgrrf1 35
  • 69.54 (n)
  • 68.31 (a)
zebrafish
(Danio rerio)
Actinopterygii cgrrf1 35
  • 56.98 (n)
  • 51.38 (a)
cgrrf1 36
  • 50 (a)
OneToOne
Species with no ortholog for CGRRF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGRRF1 Gene

ENSEMBL:
Gene Tree for CGRRF1 (if available)
TreeFam:
Gene Tree for CGRRF1 (if available)

Paralogs for CGRRF1 Gene

(6) SIMAP similar genes for CGRRF1 Gene using alignment to 5 proteins:

genes like me logo Genes that share paralogs with CGRRF1: view

No data available for Paralogs for CGRRF1 Gene

Variants for CGRRF1 Gene

Sequence variations from dbSNP and Humsavar for CGRRF1 Gene

SNP ID Clin Chr 14 pos Sequence Context AA Info Type
rs11555279 - 54,530,154(-) TGAAG(C/G/T)AATAA reference, missense
rs1130012 -- 54,538,147(+) TGTTG(A/G)AAAAG reference, missense
rs1130093 -- 54,538,609(+) CTCTT(A/G)AAAAA utr-variant-3-prime
rs1959806 -- 54,535,461(-) CAGAT(A/G)TAAAA intron-variant
rs1959807 -- 54,531,732(-) AACTA(C/T)CAGAC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CGRRF1 Gene

Variant ID Type Subtype PubMed ID
nsv832802 CNV Loss 17160897

Variation tolerance for CGRRF1 Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.09; 61.04% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CGRRF1 Gene

HapMap Linkage Disequilibrium report
CGRRF1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGRRF1 Gene

Disorders for CGRRF1 Gene

Relevant External Links for CGRRF1

Genetic Association Database (GAD)
CGRRF1
Human Genome Epidemiology (HuGE) Navigator
CGRRF1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CGRRF1

No disorders were found for CGRRF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CGRRF1 Gene

Publications for CGRRF1 Gene

  1. Induction of cell growth regulatory genes by p53. (PMID: 8968090) Madden S.L. … Beaudry G.A. (Cancer Res. 1996) 2 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. CGRRF1 as a novel biomarker of tissue response to metformin in the context of obesity. (PMID: 24680596) Zhang Q. … Lu K.H. (Gynecol. Oncol. 2014) 3
  4. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PMID: 22493164) Woodsmith J. … Sanderson C.M. (Mol. Cell Proteomics 2012) 3
  5. Genome-wide association scan of dental caries in the permanent dentition. (PMID: 23259602) Wang X. … Marazita M.L. (BMC Oral Health 2012) 3

Products for CGRRF1 Gene

Sources for CGRRF1 Gene

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