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CGRRF1 Gene

protein-coding   GIFtS: 51
GCID: GC14P054976

Cell Growth Regulator With Ring Finger Domain 1

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cell Growth Regulator With Ring Finger Domain 11 2     RING Finger Protein 1972 3
CGR192 3 5     Cell Growth Regulator With RING Finger Domain Protein 12
Cell Growth Regulatory Gene 19 Protein2 3     GCRRF15
RNF1972 3     

External Ids:    HGNC: 155281   Entrez Gene: 106682   Ensembl: ENSG000001005327   OMIM: 6061385   UniProtKB: Q996753   

Export aliases for CGRRF1 gene to outside databases

Previous GC identifers: GC14P052966 GC14P054046 GC14P035139


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CGRRF1 Gene:
CGRRF1 (cell growth regulator with ring finger domain 1) is a protein-coding gene.

UniProtKB/Swiss-Prot: CGRF1_HUMAN, Q99675
Function: Able to inhibit growth in several cell lines (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000014.8  NC_018925.2  NT_026437.13  
Regulatory elements:
   Regulatory transcription factor binding sites in the CGRRF1 gene promoter:
         SRF   SRF (504 AA)   HNF-1A   CREB   Pax-3   FOXC1   deltaCREB   HNF-1   Zic1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CGRRF1 promoter sequence
   Search Chromatin IP Primers for CGRRF1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CGRRF1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 14q22.2   Ensembl cytogenetic band:  14q22.2   HGNC cytogenetic band: 14q22.2

CGRRF1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CGRRF1 gene location

GeneLoc information about chromosome 14         GeneLoc Exon Structure

GeneLoc location for GC14P054976:  view genomic region     (about GC identifiers)

Start:
54,976,530 bp from pter      End:
55,005,567 bp from pter
Size:
29,038 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CGRF1_HUMAN, Q99675 (See protein sequence)
Recommended Name: Cell growth regulator with RING finger domain protein 1  
Size: 332 amino acids; 38242 Da
1 PDB 3D structure from and Proteopedia for CGRRF1:
2EA5 (3D)    
Secondary accessions: Q96BX2

Explore the universe of human proteins at neXtProt for CGRRF1: NX_Q99675

Explore proteomics data for CGRRF1 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CGRRF1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_006559.1  
    ENSEMBL proteins: 
     ENSP00000451532   ENSP00000216420   ENSP00000450430   ENSP00000450728   ENSP00000470702  

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    Cloud-Clone Corp. Proteins for CGRRF1

     
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    RNF: RING-type (C3HC4) zinc fingers

    2 InterPro protein domains:
     IPR001841 Znf_RING
     IPR013083 Znf_RING/FYVE/PHD

    Graphical View of Domain Structure for InterPro Entry Q99675

    ProtoNet protein and cluster: Q99675

    1 Blocks protein domain: IPB001841 Zn-finger

    UniProtKB/Swiss-Prot: CGRF1_HUMAN, Q99675
    Similarity: Contains 1 RING-type zinc finger


    Find genes that share domains with CGRRF1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CGRF1_HUMAN, Q99675
    Function: Able to inhibit growth in several cell lines (By similarity)

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005515protein binding ----
    GO:0008270zinc ion binding IEA--
         
    Find genes that share ontologies with CGRRF1           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CGRRF1:
     Elongated cells with protrusio 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CGRRF1
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    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CGRRF1:
    hsa-miR-544
    SwitchGear 3'UTR luciferase reporter plasmidCGRRF1 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CGRRF1
    Predesigned siRNA for gene silencing in human, mouse, rat CGRRF1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CGRF1_HUMAN, Q99675: Nucleus
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus5
    extracellular3
    plasma membrane2
    endoplasmic reticulum1
    lysosome1

    Gene Ontology (GO): 3 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005634nucleus IDA--
    GO:0005730NOT nucleolus IDA--
    GO:0043231intracellular membrane-bounded organelle IDA--

    Find genes that share ontologies with CGRRF1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Pathway & Disease-focused RT2 Profiler PCR Array including CGRRF1: 
              Ubiquitin Ligases in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CGRRF1

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    4 Interacting proteins for CGRRF1 (Q996753 ENSP000002164204) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    UBE2UQ5VVX93, ENSP000003601164I2D: score=2 STRING: ENSP00000360116
    CREB3O438893I2D: score=1 
    PEX10ENSP000002887744STRING: ENSP00000288774
    UBCENSP000003448184STRING: ENSP00000344818
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    Gene Ontology (GO): 3 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006950response to stress TAS8968090
    GO:0007050cell cycle arrest IEA--
    GO:0008285negative regulation of cell proliferation TAS8968090

    Find genes that share ontologies with CGRRF1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CGRRF1 (CGRF1)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CGRRF1 gene: 
    NM_006568.2  

    Unigene Cluster for CGRRF1:

    Cell growth regulator with ring finger domain 1
    Hs.59106  [show with all ESTs]
    Unigene Representative Sequence: AK090727
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000554791 ENST00000216420(uc010tra.1 uc001xay.3) ENST00000556216
    ENST00000557317 ENST00000557755 ENST00000557512 ENST00000557184 ENST00000557429
    ENST00000556172
    miRNA
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    Block miRNA regulation of human, mouse, rat CGRRF1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CGRRF1:
    hsa-miR-544
    SwitchGear 3'UTR luciferase reporter plasmidCGRRF1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CGRRF1
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      QuantiTect SYBR Green Assays in human, mouse, rat CGRRF1
      QuantiFast Probe-based Assays in human, mouse, rat CGRRF1

    Additional mRNA sequence: 

    AK090727.1 AK289478.1 AK315318.1 BC015063.1 U66469.1 

    9 DOTS entries:

    DT.313498  DT.100790306  DT.100023789  DT.100809081  DT.95374754  DT.120763577  DT.75187532  DT.91668120 
    DT.95374755 

    Selected AceView cDNA sequences (see all 131):

    NM_006568 BM052880 U66469 AW664053 BQ004774 AI300249 CD108348 AA379787 
    BG661242 AI378687 BP370370 AI077398 AI363454 AA825685 AA885367 BU169892 
    AA634503 AA363995 BQ640768 AA761310 AA768422 BP371294 CD364323 AA609078 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CGRRF1 (see all 14)    About this scheme

    ExUns: 1 ^ 2a · 2b ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10a · 10b ^ 11a · 11b · 11c · 11d
    SP1:        -     -     -           -     -     -                 -     -     -                       -     -                                 
    SP2:        -     -     -                 -     -                 -     -     -                                                               
    SP3:        -     -     -     -     -     -     -                 -     -     -                       -     -                                 
    SP4:                    -           -     -     -                 -     -     -                       -     -                                 
    SP5:                                -     -                       -     -     -                                                               


    ECgene alternative splicing isoforms for CGRRF1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CGRRF1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAATCTACAG
    CGRRF1 Expression
    About this image

    CGRRF1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CGRRF1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.59106
        Pathway & Disease-focused RT2 Profiler PCR Array including CGRRF1: 
              Ubiquitin Ligases in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGRRF1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CGRRF1 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cgrrf11 , 5 cell growth regulator with ring finger domain 11, 5 84.4(n)1
    84.71(a)1
      14 (24.34 cM)5
    687551  NM_026832.31  NP_081108.21 
     468321345 
    chicken
    (Gallus gallus)
    Aves CGRRF11 cell growth regulator with ring finger domain 1 77.44(n)
    79.57(a)
      776040  XM_001235055.3  XP_001235056.1 
    lizard
    (Anolis carolinensis)
    Reptilia CGRRF16
    cell growth regulator with ring finger domain 1
    75(a)
    1 ↔ 1
    GL343533.1(264245-282219)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cgrrf11 cell growth regulator with ring finger domain 1 69.54(n)
    68.31(a)
      100492896  XM_002936901.2  XP_002936947.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cgrrf11 cell growth regulator with ring finger domain 1 56.98(n)
    51.38(a)
      692284  NM_001045257.1  NP_001038722.1 


    ENSEMBL Gene Tree for CGRRF1 (if available)
    TreeFam Gene Tree for CGRRF1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CGRRF1 gene
    6 SIMAP similar genes for CGRRF1 using alignment to 5 protein entries:     CGRF1_HUMAN (see all proteins):
    FAM138C    DNAPTP3    FLJ20555    AHSA1    KIAA1651    OK/SW-cl.41

    Find genes that share paralogs with CGRRF1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CGRRF1 (see all 664)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 14 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1840920601,2
    --54974598(+) TAGAGA/TCAGGG 1 -- us2k10--------
    rs1163193581,2
    F--54974745(+) GGTTTC/GAAGCT 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs1125271381,2
    C,F--54974772(+) AGATAG/ATAAAG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1885938711,2
    --54974819(+) TTTTTA/TTAAAA 1 -- us2k10--------
    rs1932517141,2
    --54974820(+) TTTTTA/TAAAAA 1 -- us2k10--------
    rs1853364021,2
    C--54974914(+) TACCCA/GACATA 1 -- us2k10--------
    rs777217251,2
    C,F--54974935(+) CGGTGG/TCACAA 1 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1874766831,2
    --54975033(+) AAGAGA/GGCTCC 1 -- us2k10--------
    rs172534871,2
    C,F--54975079(+) TCTCCC/GCAAGG 1 -- us2k14Minor allele frequency- G:0.01NA 262
    rs783238041,2
    C,F--54975096(+) AAGCAT/ACCAGG 1 -- us2k12Minor allele frequency- A:0.08WA EA 238

    HapMap Linkage Disequilibrium report for CGRRF1 (54976530 - 55005567 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 1 variation for CGRRF1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv832802CNV Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CGRRF1
    DNA2.0 Custom Variant and Variant Library Synthesis for CGRRF1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 606138    OMIM disorders: --


    Find genes that share disorders with CGRRF1           About GenesLikeMe

    Genetic Association Database (GAD): CGRRF1
    Human Genome Epidemiology (HuGE) Navigator: CGRRF1 (1 document)

    Export disorders for CGRRF1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CGRRF1 gene, integrated from 10 sources (see all 12):
    (articles sorted by number of sources associating them with CGRRF1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Induction of cell growth regulatory genes by p53. (PubMed id 8968090)1, 2, 3 Madden S.L.... Beaudry G.A. (Cancer Res. 1996)
    2. An approach based on a genome-wide association study reveals candidate loci for narcolepsy. (PubMed id 20677014)1, 4 Shimada M....Tokunaga K. (Hum. Genet. 2010)
    3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    4. Systematic analysis of dimeric E3-RING interactions reveals increased combinatorial complexity in human ubiquitination networks. (PubMed id 22493164)1 Woodsmith J....Sanderson C.M. (amp 2012)
    5. Systematic validation of antibody binding and protein subcellular localization using siRNA and confocal microscopy. (PubMed id 22361696)2 Stadler C.... Lundberg E. (J. Proteomics 2012)
    6. Genome-wide association scan of dental caries in the permanent dentition. (PubMed id 23259602)1 Wang X....Marazita M.L. (BMC Oral Health 2012)
    7. Systematic and quantitative assessment of the ubiquitin-modified proteome. (PubMed id 21906983)1 Kim W....Gygi S.P. (Mol. Cell 2011)
    8. A comprehensive framework of E2-RING E3 interactions of the human ubiquitin-proteasome system. (PubMed id 19690564)1 van Wijk S.J....Timmers H.T. (Mol. Syst. Biol. 2009)
    9. Toward a confocal subcellular atlas of the human proteome. (PubMed id 18029348)1 Barbe L....Andersson-Svahn H. (amp 2008)
    10. hORFeome v3.1: a resource of human open reading frames representing over 10,000 human genes. (PubMed id 17207965)1 Lamesch P.... Vidal M. (Genomics 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10668 HGNC: 15528 AceView: CGRRF1 Ensembl:ENSG00000100532 euGenes: HUgn10668
    ECgene: CGRRF1 H-InvDB: CGRRF1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CGRRF1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CGRRF1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CGRRF1 gene:
    Search GeneIP for patents involving CGRRF1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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