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Aliases for CGREF1 Gene

Aliases for CGREF1 Gene

  • Cell Growth Regulator With EF-Hand Domain 1 2 3 5
  • Cell Growth Regulatory Gene 11 Protein 3 4
  • Hydrophobestin 3 4
  • CGR11 3 4
  • Cell Growth Regulator With EF Hand Domain Protein 1 3

External Ids for CGREF1 Gene

Previous GeneCards Identifiers for CGREF1 Gene

  • GC02M027280
  • GC02M027298
  • GC02M027235
  • GC02M027176
  • GC02M027321
  • GC02M027064

Summaries for CGREF1 Gene

GeneCards Summary for CGREF1 Gene

CGREF1 (Cell Growth Regulator With EF-Hand Domain 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding.

UniProtKB/Swiss-Prot for CGREF1 Gene

  • Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGREF1 Gene

Genomics for CGREF1 Gene

Regulatory Elements for CGREF1 Gene

Enhancers for CGREF1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH02F027085 1.4 Ensembl ENCODE 10.8 +31.6 31641 4.8 HDGF CREB3L1 MLX ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF143 KHK SLC5A6 ATRAID ABHD1 CGREF1 PREB TRIM54 UCN MPV17 LOC100129724
GH02F027091 1.3 Ensembl ENCODE 11.1 +25.0 25013 7.0 CREB3L1 MLX ZFP64 ARID4B DMAP1 YY1 SLC30A9 ZNF143 PAF1 SP5 KHK EMILIN1 ABHD1 CGREF1 SLC5A6 ATRAID CAD PRR30 TCF23 PREB
GH02F027169 1.3 Ensembl ENCODE 10.5 -52.1 -52142 2.9 ATF1 MLX ARID4B DMAP1 ZNF48 YY1 ZNF143 ZNF263 SP5 ZHX2 ATRAID GTF3C2 TCF23 PRR30 PREB SLC5A6 ABHD1 CAD DNAJC5G SLC30A3
GH02F027953 1.6 FANTOM5 Ensembl ENCODE 4.1 -838.6 -838574 9.4 PKNOX1 MLX SIN3A YY1 FOS REST PPARG SSRP1 PBX2 STAT3 FOSL2 RBKS FLJ31356 FNDC4 C2orf16 CGREF1 LINC01460 BRE GCKR LOC100422227
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CGREF1 on UCSC Golden Path with GeneCards custom track

Promoters for CGREF1 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00001820890 227 201 MXI1 SIN3A ZIC2 HIC1 GLIS2 POLR2A EZH2 RNF2 NRF1 MNT

Genomic Location for CGREF1 Gene

27,098,889 bp from pter
27,119,127 bp from pter
20,239 bases
Minus strand

Genomic View for CGREF1 Gene

Genes around CGREF1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGREF1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGREF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGREF1 Gene

Proteins for CGREF1 Gene

  • Protein details for CGREF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cell growth regulator with EF hand domain protein 1
    Protein Accession:
    Secondary Accessions:
    • A6NHV7
    • B4DXY8
    • B5MCB7
    • B5MCC9
    • B5MCP5
    • E7EU99
    • Q8N4B7

    Protein attributes for CGREF1 Gene

    301 amino acids
    Molecular mass:
    31905 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CGREF1 Gene


neXtProt entry for CGREF1 Gene

Post-translational modifications for CGREF1 Gene

  • Probably digested extracellularly by an unknown serine protease generating extremely hydrophobic bioactive peptides.
  • Glycosylation at Ser 69, Ser 159, Ser 170, and Thr 181
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CGREF1 Gene

Domains & Families for CGREF1 Gene

Gene Families for CGREF1 Gene

Protein Domains for CGREF1 Gene

Suggested Antigen Peptide Sequences for CGREF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Both EF-hands are required for function.
  • Both EF-hands are required for function.
  • Contains 2 EF-hand domains.
genes like me logo Genes that share domains with CGREF1: view

Function for CGREF1 Gene

Molecular function for CGREF1 Gene

UniProtKB/Swiss-Prot Function:
Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines.
UniProtKB/Swiss-Prot Induction:
By p53/TP53.

Gene Ontology (GO) - Molecular Function for CGREF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0046872 metal ion binding IEA --
genes like me logo Genes that share ontologies with CGREF1: view
genes like me logo Genes that share phenotypes with CGREF1: view

Animal Model Products

  • Taconic Biosciences Mouse Models for CGREF1

Inhibitory RNA Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CGREF1 Gene

Localization for CGREF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGREF1 Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CGREF1 gene
Compartment Confidence
extracellular 4
cytoskeleton 2
nucleus 2
cytosol 2
golgi apparatus 2
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CGREF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CGREF1: view

Pathways & Interactions for CGREF1 Gene

SuperPathways for CGREF1 Gene

No Data Available

Interacting Proteins for CGREF1 Gene

Gene Ontology (GO) - Biological Process for CGREF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress TAS 8968090
GO:0007049 cell cycle IEA --
GO:0007050 cell cycle arrest IEA --
GO:0007155 cell adhesion IEA --
GO:0008285 negative regulation of cell proliferation TAS 8968090
genes like me logo Genes that share ontologies with CGREF1: view

No data available for Pathways by source and SIGNOR curated interactions for CGREF1 Gene

Transcripts for CGREF1 Gene

Unigene Clusters for CGREF1 Gene

Cell growth regulator with EF-hand domain 1:
Representative Sequences:

Inhibitory RNA Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CGREF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6

Relevant External Links for CGREF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CGREF1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CGREF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CGREF1 Gene

This gene is overexpressed in Lavage (50.7).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CGREF1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CGREF1 Gene:


SOURCE GeneReport for Unigene cluster for CGREF1 Gene:

genes like me logo Genes that share expression patterns with CGREF1: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CGREF1 Gene

Orthologs for CGREF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGREF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CGREF1 34 35
  • 99.16 (n)
(Bos Taurus)
Mammalia CGREF1 34 35
  • 80.79 (n)
(Canis familiaris)
Mammalia CGREF1 34 35
  • 80.64 (n)
(Mus musculus)
Mammalia Cgref1 34 16 35
  • 75.3 (n)
(Rattus norvegicus)
Mammalia Cgref1 34
  • 74.4 (n)
(Monodelphis domestica)
Mammalia CGREF1 35
  • 46 (a)
(Danio rerio)
Actinopterygii CGREF1 35
  • 25 (a)
Species where no ortholog for CGREF1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGREF1 Gene

Gene Tree for CGREF1 (if available)
Gene Tree for CGREF1 (if available)

Paralogs for CGREF1 Gene

No data available for Paralogs for CGREF1 Gene

Variants for CGREF1 Gene

Sequence variations from dbSNP and Humsavar for CGREF1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs10190104 -- 27,109,286(+) aggat(C/G)gcttg intron-variant
rs10202362 -- 27,118,277(+) caggc(C/G)ggcag intron-variant
rs10563799 -- 27,113,116(+) GAGAG(-/AG)GGCTG intron-variant
rs1057389 -- 27,101,503(-) AGCTG(A/G)GGGCC intron-variant, reference, missense
rs1057391 -- 27,101,486(-) AGGCT(A/G)AAGGA intron-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CGREF1 Gene

Variant ID Type Subtype PubMed ID
nsv833603 CNV loss 17160897
nsv817673 CNV gain 17921354
nsv455974 CNV loss 19166990
esv989926 CNV deletion 20482838
esv3590133 CNV loss 21293372
esv2719834 CNV deletion 23290073
esv2719833 CNV deletion 23290073
esv2673470 CNV deletion 23128226
esv1742991 CNV deletion 17803354
dgv6744n54 CNV loss 21841781

Variation tolerance for CGREF1 Gene

Residual Variation Intolerance Score: 63% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 2.72; 46.59% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CGREF1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGREF1 Gene

Disorders for CGREF1 Gene

Relevant External Links for CGREF1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CGREF1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CGREF1 Gene

Publications for CGREF1 Gene

  1. Induction of cell growth regulatory genes by p53. (PMID: 8968090) Madden S.L. … Beaudry G.A. (Cancer Res. 1996) 2 3 4 64
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 46 64
  3. The novel secretory protein CGREF1 inhibits the activation of AP-1 transcriptional activity and cell proliferation. (PMID: 26022276) Deng W. … Ma D. (Int. J. Biochem. Cell Biol. 2015) 3 64
  4. Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines. (PMID: 24483146) Li L. … Wang L. (BMC Genomics 2014) 3 64
  5. Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip. (PMID: 19913121) Talmud P.J. … . (Am. J. Hum. Genet. 2009) 3 64

Products for CGREF1 Gene

Sources for CGREF1 Gene

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