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Aliases for CGREF1 Gene

Aliases for CGREF1 Gene

  • Cell Growth Regulator With EF-Hand Domain 1 2 3
  • Cell Growth Regulatory Gene 11 Protein 3 4
  • Hydrophobestin 3 4
  • CGR11 3 4
  • Cell Growth Regulator With EF Hand Domain Protein 1 3
  • Cell Growth Regulator With EF Hand Domain 1 3

External Ids for CGREF1 Gene

Previous GeneCards Identifiers for CGREF1 Gene

  • GC02M027280
  • GC02M027298
  • GC02M027235
  • GC02M027176
  • GC02M027321
  • GC02M027064

Summaries for CGREF1 Gene

GeneCards Summary for CGREF1 Gene

CGREF1 (Cell Growth Regulator With EF-Hand Domain 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding.

UniProtKB/Swiss-Prot for CGREF1 Gene

  • Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGREF1 Gene

Genomics for CGREF1 Gene

Regulatory Elements for CGREF1 Gene

Genomic Location for CGREF1 Gene

27,098,889 bp from pter
27,119,127 bp from pter
20,239 bases
Minus strand

Genomic View for CGREF1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CGREF1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGREF1 Gene

Proteins for CGREF1 Gene

  • Protein details for CGREF1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cell growth regulator with EF hand domain protein 1
    Protein Accession:
    Secondary Accessions:
    • A6NHV7
    • B4DXY8
    • B5MCB7
    • B5MCC9
    • B5MCP5
    • E7EU99
    • Q8N4B7

    Protein attributes for CGREF1 Gene

    301 amino acids
    Molecular mass:
    31905 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CGREF1 Gene


neXtProt entry for CGREF1 Gene

Proteomics data for CGREF1 Gene at MOPED

Post-translational modifications for CGREF1 Gene

  • Probably digested extracellularly by an unknown serine protease generating extremely hydrophobic bioactive peptides.
  • Glycosylation at Thr61, Ser69, Ser159, Ser170, Ser175, and Thr181
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CGREF1 Gene

Domains for CGREF1 Gene

Gene Families for CGREF1 Gene

  • EFHAND :EF-hand domain containing

Protein Domains for CGREF1 Gene

Suggested Antigen Peptide Sequences for CGREF1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Q99674
  • Both EF-hands are required for function.
  • Contains 2 EF-hand domains.
genes like me logo Genes that share domains with CGREF1: view

Function for CGREF1 Gene

Molecular function for CGREF1 Gene

UniProtKB/Swiss-Prot Function: Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in several cell lines.
UniProtKB/Swiss-Prot Induction: By p53/TP53.

Gene Ontology (GO) - Molecular Function for CGREF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
genes like me logo Genes that share ontologies with CGREF1: view

Phenotypes for CGREF1 Gene

genes like me logo Genes that share phenotypes with CGREF1: view

Animal Model Products

CRISPR Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CGREF1 Gene

Localization for CGREF1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGREF1 Gene


Subcellular locations from

Jensen Localization Image for CGREF1 Gene COMPARTMENTS Subcellular localization image for CGREF1 gene
Compartment Confidence
extracellular 2
cytoskeleton 1
cytosol 1
endoplasmic reticulum 1
golgi apparatus 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CGREF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CGREF1: view

Pathways for CGREF1 Gene

SuperPathways for CGREF1 Gene

No Data Available

Interacting Proteins for CGREF1 Gene

Gene Ontology (GO) - Biological Process for CGREF1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006950 response to stress TAS 8968090
GO:0007050 cell cycle arrest IEA --
GO:0007155 cell adhesion IEA --
GO:0008285 negative regulation of cell proliferation TAS 8968090
GO:0030308 negative regulation of cell growth IEA --
genes like me logo Genes that share ontologies with CGREF1: view

No data available for Pathways by source for CGREF1 Gene

Transcripts for CGREF1 Gene

Unigene Clusters for CGREF1 Gene

Cell growth regulator with EF-hand domain 1:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CGREF1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CGREF1 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6

Relevant External Links for CGREF1 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CGREF1 Gene

mRNA expression in normal human tissues for CGREF1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CGREF1 Gene

SOURCE GeneReport for Unigene cluster for CGREF1 Gene Hs.159525

genes like me logo Genes that share expressions with CGREF1: view

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CGREF1 Gene

Orthologs for CGREF1 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGREF1 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CGREF1 35
  • 99.16 (n)
  • 98.11 (a)
  • 71 (a)
(Bos Taurus)
Mammalia CGREF1 35
  • 80.79 (n)
  • 72.9 (a)
  • 72 (a)
(Canis familiaris)
Mammalia CGREF1 35
  • 80.64 (n)
  • 73.46 (a)
  • 49 (a)
(Mus musculus)
Mammalia Cgref1 35
  • 75.3 (n)
  • 66.91 (a)
Cgref1 16
Cgref1 36
  • 56 (a)
(Monodelphis domestica)
Mammalia CGREF1 36
  • 46 (a)
(Rattus norvegicus)
Mammalia Cgref1 35
  • 74.4 (n)
  • 65.58 (a)
(Danio rerio)
Actinopterygii CGREF1 36
  • 25 (a)
Species with no ortholog for CGREF1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGREF1 Gene

Gene Tree for CGREF1 (if available)
Gene Tree for CGREF1 (if available)

Paralogs for CGREF1 Gene

No data available for Paralogs for CGREF1 Gene

Variants for CGREF1 Gene

Sequence variations from dbSNP and Humsavar for CGREF1 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1057389 - 27,101,503(-) AGCTG(A/G)GGGCC missense, reference, intron-variant
rs1057391 -- 27,101,486(-) AGGCT(A/G)AAGGA missense, reference, intron-variant
rs1057393 -- 27,101,421(-) GCCCC(C/T)GGGCC reference, synonymous-codon, intron-variant
rs1866559 -- 27,112,718(+) AACCA(C/T)ATTAT intron-variant, upstream-variant-2KB
rs1866560 -- 27,105,685(-) CCTGT(A/C)ATCCC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CGREF1 Gene

Variant ID Type Subtype PubMed ID
nsv455974 CNV Loss 19166990
nsv817673 CNV Gain 17921354
nsv833603 CNV Loss 17160897
esv2673470 CNV Deletion 23128226
esv2719833 CNV Deletion 23290073
esv989926 CNV Deletion 20482838
esv2719834 CNV Deletion 23290073
esv1742991 CNV Deletion 17803354
nsv873753 CNV Loss 21882294

Relevant External Links for CGREF1 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGREF1 Gene

Disorders for CGREF1 Gene

(1) University of Copenhagen DISEASES for CGREF1 Gene

Relevant External Links for CGREF1

Genetic Association Database (GAD)
Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CGREF1: view

No data available for UniProtKB/Swiss-Prot for CGREF1 Gene

Publications for CGREF1 Gene

  1. Induction of cell growth regulatory genes by p53. (PMID: 8968090) Madden S.L. … Beaudry G.A. (Cancer Res. 1996) 2 3 4
  2. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PMID: 20628086) Bailey S.D. … Anand S. (Diabetes Care 2010) 3 48
  3. Discovery of genetic biomarkers contributing to variation in drug response of cytidine analogues using human lymphoblastoid cell lines. (PMID: 24483146) Li L. … Wang L. (BMC Genomics 2014) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 4
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4

Products for CGREF1 Gene

Sources for CGREF1 Gene

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