CGREF1 Gene
protein-coding GIFtS : 46
GCID: GC02 M027321
cell growth regulator with EF-hand domain 1
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Aliasesfor CGREF1 gene
(According to
1 HGNC ,
2 Entrez Gene ,
3 UniProtKB/Swiss-Prot ,
4 UniProtKB/TrEMBL , 5 OMIM , 6 GeneLoc ,
7 Ensembl ,
8 DME ,
9 miRBase ,
and/or 10 fRNAdb )About This Section Aliases Cell Growth Regulator With EF-Hand Domain 1 1 2 Cell Growth Regulator With EF Hand Domain Protein 12 CGR111 2 3 Hydrophobestin3 Cell Growth Regulatory Gene 11 Protein2 3 Hydrophobestin3 Cell Growth Regulator With EF Hand Domain 12
Export aliases for CGREF1 gene to outside databases Previous GC identifers: GC02M027280 GC02M027298 GC02M027235 GC02M027176 GC02M027064
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Summariesfor CGREF1 gene (According to Entrez Gene ,
Tocris Bioscience ,
Wikipedia's
Gene Wiki ,
PharmGKB ,
UniProtKB/Swiss-Prot ,
and/or
UniProtKB/TrEMBL )
About This Section UniProtKB/Swiss-Prot: CGRE1_HUMAN, Q99674 Function : Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in severalcell lines
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Genomic Viewsfor CGREF1 gene
(According to
GeneLoc and/or
HGNC , and/or
Entrez Gene (NCBI build 37) ,
and/or miRBase ,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69) ,
Regulatory elements and Epigenetics data according to
QIAGEN ,
SABiosciences , and/or
SwitchGear Genomics )About This Section RefSeq DNA sequence: NC_000002.11 NC_018913.1 NT_022184.15 Regulatory elements: SABiosciences Regulatory transcription factor binding sites in the CGREF1 gene promoter: Nkx2-2 AP-2gamma LCR-F1 HNF-4alpha1 AREB6 HEN1 STAT3 AP-2beta AP-2alpha AP-2alphaA Other transcription factors Search SABiosciences Chromatin IP Primers for CGREF1 Epigenetics: QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CGREF1
Genomic Location: Genomic View : UCSC Golden Path with GeneCards custom track Entrez Gene cytogenetic band: 2p23.3 Ensembl cytogenetic band: 2p23.3 HGNC cytogenetic band: 2p23.3 CGREF1 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different) GeneLoc information about chromosome 2 GeneLoc Exon Structure
GeneLoc location for GC02M027321: view genomic region
(about GC identifiers )
Start:
27,321,757 bp from pter
End:
27,341,995 bp from pter
Size:
20,239 bases
Orientation:
minus strand
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Proteinsfor CGREF1 gene
(According to
1 UniProtKB ,
HORDE ,
neXtProt ,
Ensembl ,
and/or Reactome ,
Modification sites according to 2 PhosphoSitePlus ,
Specific Peptides from DME ,
Protein expression images according to data from SPIRE MOPED and PaxDb ,
RefSeq according to NCBI ,
PDB rendering according to OCA and/or Proteopedia ,
Recombinant Proteins
from
EMD Millipore ,
R&D Systems ,
GenScript ,
Enzo Life Sciences ,
OriGene ,
Novus Biologicals ,
Sino Biological ,
ProSpec , and/or
Uscn ,
Biochemical Assays by
EMD Millipore ,
R&D Systems ,
OriGene ,
GenScript ,
Cell Signaling Technology ,
Enzo Life Sciences , and/or
Uscn ,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene ,
Antibodies by
EMD Millipore ,
R&D Systems ,
GenScript ,
Cell Signaling Technology ,
OriGene ,
Novus Biologicals ,
Thermo Fisher Scientific ,
Abcam , and/or
Uscn )
About This Section UniProtKB/Swiss-Prot: CGRE1_HUMAN, Q99674 (See
protein sequence )Recommended Name: Cell growth regulator with EF hand domain protein 1 precursor Size : 301 amino acids; 31905 Da
Subcellular location : Secreted (By similarity)
Secondary accessions : A6NHV7 B5MCB7 Q8N4B7Alternative splicing : 2 isoforms : Q99674-1 Q99674-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CGREF1: NX_Q99674 Post-translational modifications:
Probably digested extracellularly by an unknown serine protease generating extremely hydrophobic bioactive peptides (By similarity)1
View modification sites using PhosphoSitePlus 2 View neXtProt modification sites for NX_Q99674 CGREF1 Protein expression data from MOPED and PaxDb : About this image
REFSEQ proteins (4 alternative transcripts):
NP_001159711.1 NP_001159712.1 NP_001159713.1 NP_006560.3 ENSEMBL proteins: ENSP00000394306 ENSP00000385103 ENSP00000385452 ENSP00000386113 ENSP00000324025 ENSP00000385574 ENSP00000395042 ENSP00000260595 Human Recombinant Protein Products: Gene Ontology (GO): 1 cellular component term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005576 extracellular region
IEA --
CGREF1 for ontologies About GeneDecksing CGREF1 Antibody Products: Assay Products for CGREF1:
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Protein
Domains / Familiesfor CGREF1 gene (According to InterPro , ProtoNet ,
UniProtKB , and/or BLOCKS ,
Sets of similar genes according to GeneDecks )
About This Section
CGREF1 for domains About GeneDecksing 3 InterPro domains/families :
Graphical View of Domain Structure for InterPro Entry Q99674 ProtoNet protein and cluster: Q99674
UniProtKB/Swiss-Prot: CGRE1_HUMAN, Q99674 Domain : Both EF-hands are required for function (By similarity)Similarity : Contains 2 EF-hand domains
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Functionfor CGREF1 gene
(According to 1 UniProtKB ,
Genatlas ,
LifeMap Discovery™ ,
IUBMB , and/or
2 DME ,
Human phenotypes from GenomeRNAi ,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences ,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene ,
RNAi from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
microRNA from QIAGEN ,
Gene Editing from DNA2.0 ,
Clones from EMD Millipore ,
OriGene ,
SwitchGear Genomics ,
GenScript ,
Sino Biological ,
DNA2.0 ,
and Vector BioLabs ,
Cell Lines from GenScript ,
LifeMap BioReagents ,
In Situ Hybridization Assays from Advanced Cell Diagnostics ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene .)
About This Section Function Summary: UniProtKB/Swiss-Prot: CGRE1_HUMAN, Q99674 Function : Mediates cell-cell adhesion in a calcium-dependent manner (By similarity). Able to inhibit growth in severalcell lines Induction : By p53/TP53
Clone Products: Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CGREF1 (see all 8 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CGREF1 (see all 5 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 4 ): CGREF1 (NM_006569 ) Browse Sino Biological Human cDNA Clones DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CGREF1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CGREF1
In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGREF1
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view) : About this table
GO ID Qualified GO term Evidence PubMed IDs GO:0005509 calcium ion binding
IEA --
CGREF1 for ontologies About GeneDecksing 1 GenomeRNAi human phenotype for CGREF1 :
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Pathways & Interactionsfor CGREF1 gene
(Pathways according to
EMD Millipore ,
R&D Systems ,
Cell Signaling Technology ,
KEGG ,
PharmGKB ,
BioSystems ,
Reactome ,
Tocris Bioscience ,
GeneGo (Thomson Reuters) ,
QIAGEN ,
and/or UniProtKB ,
Sets of similar genes according to GeneDecks ,
Interaction Networks according to
SABiosciences ,
and/or STRING ,
Interactions according to 1 UniProtKB ,
2 MINT ,
3 I2D , and/or
4 STRING ,
with links to IntAct and
Ensembl ,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene) .
About This Section Interactions: Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CGREF1 Gene Ontology (GO): 5 biological process terms (GO ID links to tree view) : About this table
CGREF1 for ontologies About GeneDecksing
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Drugs & Compoundsfor CGREF1 gene (Chemical Compounds according to UniProtKB , Enzo Life Sciences ,
EMD Millipore , Tocris Bioscience
HMDB ,
BitterDB , and/or
Novoseek , and Drugs according to
DrugBank ,
Enzo Life Sciences , and/or
PharmGKB , with drugs/clinical trials/news
search links to CenterWatch )
About This Section Browse Tocris compounds for CGREF1 Search CenterWatch for drugs/clinical trials and news about CGREF1 / CGRE1
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Transcriptsfor CGREF1 gene (Secondary structures according to
fRNAdb ,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank , RefSeq according to Entrez Gene ,
DOTS (version 10), and/or
AceView ,
transcript ids from Ensembl
with links to UCSC ,
exon structure from GeneLoc ,
alternative splicing isoforms according to ASD and/or
ECgene ,
RNAi Products from
EMD Millipore ,
siRNAs from
OriGene ,
QIAGEN ,
shRNA from
OriGene ,
microRNA from QIAGEN ,
Tagged/untagged cDNA clones from
OriGene ,
SwitchGear Genomics ,
GenScript ,
DNA2.0 ,
Vector BioLabs ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN
)About This Section REFSEQ mRNAs for CGREF1 gene (4 alternative transcripts): NM_001166239.1 NM_001166240.1 NM_001166241.1 NM_006569.5 Unigene Cluster for CGREF1:
Cell growth regulator with EF-hand domain 1 Hs.159525 [show with all ESTs ] Unigene Representative Sequence: NM_006569 9 Ensembl transcripts including schematic representations, and UCSC links where relevant : ENST00000440612 ENST00000402550 (uc021vez.1 ) ENST00000402394 (uc002riq.3 uc021vfa.1 uc002rir.2 )ENST00000405600 (uc010eys.2 ) ENST00000312734 ENST00000404694 (uc010eyr.2 )ENST00000467539 ENST00000452318 (uc010ylf.2 ) ENST00000260595 Clone Products: OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CGREF1 (see all 8 ) OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CGREF1 (see all 5 )OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling GenScript: all cDNA clones in your preferred vector (see all 4 ): CGREF1 (NM_006569 ) DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CGREF1 Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CGREF1
Additional cDNA sequence: AK290128.1 AK302185.1 AK309147.1 BC034764.1 U66468.1
7 DOTS entries : DT.95104790 DT.447396
DT.447395 DT.100773249 DT.97851257 DT.121007671 DT.97846451 24/66 AceView cDNA sequences (see all 66 ):
BM711657 CR619230 BM849276 BM673850 BM785106 CR593274 BQ446998 AA325461 CR623121 Z41432 CB160391 NM_006569 BM738764 BM716977 BX419588 AA814489 AL525583 BM742679 AL536349 AW071890 AU141077 BF063291 T33525 AI880122 GeneLoc Exon Structure 2 Alternative Splicing Database (ASD) splice patterns (SP) for CGREF1 About this scheme ExUns: 1a · 1b ^ 2 ^ 3 ^ 4a · 4b ^ 5 ^ 6 SP1 :                 SP2 :                
ECgene alternative splicing isoforms for CGREF1
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Expression for CGREF1 gene
(RNA expression data according to
H-InvDB ,
NONCODE ,
miRBase , and
RNAdb ,
Expression images according to data from
BioGPS ,
Illumina Human BodyMap , and
CGAP
SAGE ,
Sets of similar genes according to GeneDecks ,
in vivo and in vitro expression data from LifeMap Discovery™ ,
plus additional links to
Genevestigator , and/or
SOURCE , and/or
BioGPS , and/or
UniProtKB ,
PCR Arrays from
SABiosciences ,
Primers from
OriGene ,
SABiosciences , and/or
QIAGEN ,
In Situ Hybridization Assays from Advanced Cell Diagnostics )
About This Section CGREF1 expression in normal human tissues (normalized intensities) See probesets specificity/sensitivity at GeneAnnot About this image BioGPS CGAP TAG: CTGGGCATTT
About this image CGREF1 expression in embryonic tissues and stem cells Expression by the Database of Embryonic development, Stem cell research, and
Regenerative medicine About this table See CGREF1 Protein Expression from SPIRE MOPED and PaxDB Genevestigator expression for CGREF1 SOURCE GeneReport for Unigene cluster: Hs.159525 SABiosciences Custom PCR Arrays for CGREF1 Primer Products: OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CGREF1Browse OriGene validated miRNA SYBR primer pairs SABiosciences RT2 qPCR Primer Assay in human , mouse , rat CGREF1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CGREF1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CGREF1 In Situ Assay Products: Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGREF1
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Orthologsfor CGREF1 gene
(Orthologs according to
1,2 HomoloGene (2 older version, for species not in 1 newer version),
3 euGenes ,
4 SGD
,
5 MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase ,
and/or
6 Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam )
About This Section
This gene was present in the common ancestor of chordates.
Orthologs for CGREF1 gene from 2/7 species (see all 7 ) About this table
ENSEMBL Gene Tree for CGREF1 (if available)TreeFam Gene Tree for CGREF1 (if available)
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Paralogsfor CGREF1 gene (Paralogs according to
1 HomoloGene , 2 Ensembl , and 3 SIMAP , Pseudogenes according to 4 Pseudogene.org Build 68)About This Section --
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Genomic Variantsfor CGREF1 gene (SNPs/Variants according to the
1 NCBI SNP Database ,
2 Ensembl ,
3 PupaSUITE ,
UniProtKB , and
DNA2.0 ,
Linkage Disequilibrium by HapMap ,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants , Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB) , Blood group antigen gene mutations by BGMUT ,
Resequencing Primers from QIAGEN ,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences )
About This Section
Genomic Data Transcription Related Data Allele Frequencies SNP ID Valid Clinical significance Chr 2 pos Sequence # AA Chg Type More # Allele freq Pop Total sample More
HapMap Linkage Disequilibrium report for CGREF1 (27321757 - 27341995 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions) Database of Genomic Variants (DGV): 1 variation for CGREF1 1 CNV : 9399
SABiosciences Cancer Mutation PCR Assays
QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CGREF1
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Disorders
/ Diseasesfor CGREF1 gene
(in which this Gene is Involved, According to MalaCards ,
OMIM, UniProtKB ,
the University of Copenhagen DISEASES
database ,
Genatlas , GeneTests ,
GAD ,
HuGE Navigator ,
and/or TGDB .)
About This Section
CGREF1 for disorders About MalaCards
CGREF1 for disorders About GeneDecksing
OMIM gene information: 606137
OMIM disorders : --1 disease from the University of Copenhagen DISEASES database for CGREF1 :Dermatitis herpetiformis Human Genome Epidemiology (HuGE) Navigator: CGREF1 (3 documents) Export disorders for CGREF1 gene to outside databases
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Publicationsfor CGREF1 gene (in
PubMed .
Associations of this gene to articles via
1 Entrez Gene ,
2 UniProtKB/Swiss-Prot ,
3 HGNC ,
4 GAD ,
5 PharmGKB ,
6 HMDB ,
7 DrugBank ,
8 UniProtKB/TrEMBL ,
9 Novoseek , and/or
10 fRNAdb )
About This Section PubMed articles for CGREF1 gene integrated from 9 sources : (articles sorted by number of sources associating them with CGREF1) Utopia : connect your pdf to the dynamic world of online information
Induction of cell growth regulatory genes by p53. (PubMed id 8968090) 1 , 2 , 3 Madden S.L.... Beaudry G.A. (1996) Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086) 1 Bailey S.D....Anand S. (2010) Gene-centric association signals for lipids and apoli poproteins identified via the HumanCVD BeadChip. (PubMed id 19913121) 1 Talmud P.J.... . (2009) Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560) 1 Kimura K.... Sugano S. (2006) Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621) 2 Hillier L.W....Wilson R.K. (2005) Transcriptome analysis of human gastric cancer. (PubMed id 16341674) 1 Oh J.H....Kim N.S. (2005) The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334) 2 Gerhard D.S....Malek J. (2004) Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039) 2 Ota T.... Sugano S. (2004) Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932) 1 Strausberg R.L....Marra M.A. (2002) Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548) 1 Bonaldo M.F.... Soares M.B. (1996)
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External Searches for CGREF1 gene
(in PubMed ,
OMIM , and NCBI Bookshelf ) About This Section
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Genome Databases showing CGREF1 gene
(According to
Entrez Gene ,
HGNC ,
AceView ,
euGenes ,
Ensembl ,
miRBase ,
ECgene ,
Kegg ,
and/or
H-InvDB )
About This Section
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Other Databases showing CGREF1 gene
(According to HUGE )
About This Section --
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Specialized Databases showing CGREF1 gene (According to PharmGKB ,
ATLAS , HORDE , IMGT , LEIDEN , UniProtKB/Swiss-Prot , and/or UniProtKB/TrEMBL ,Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot )About This Section
Name Description
PharmGKB entry for CGREF1 Pharmacogenomics, SNPs, Pathways
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About This Section Patent Information for CGREF1 gene: Search GeneIP for patents involving CGREF1 GeneCards and IP: Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
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Productsfor CGREF1 gene (Antibodies, recombinant proteins, and assays from EMD Millipore , R&D Systems , OriGene , QIAGEN , GenScript , Cell Signaling Technology , SABiosciences , Novus Biologicals , Sino Biological , Enzo Life Sciences , Abcam , ProSpec , Uscn , Thermo Fisher Scientific , Gene Editing from DNA2.0 , Clones from EMD Millipore , OriGene , GenScript , Sino Biological , DNA2.0 , SwitchGear Genomics , Vector BioLabs , Cell lines from GenScript and LifeMap BioReagents , PCR Arrays from SABiosciences , Drugs and/or compounds from EMD Millipore , Tocris Bioscience , and/or
Enzo Life Sciences ), In Situ Hybridization Assays from Advanced Cell Diagnostics About This Section
Browse OriGene Antibodies OriGene shRNA RFP for CGREF1 OriGene 29mer shRNA kits in GFP-retroviral vector in human , mouse , rat for CGREF1 OriGene genome-wide validated SYBR primer pairs in human , mouse , rat for CGREF1 OriGene Protein Over-expression Lysate for CGREF1 Browse OriGene Fluorogenic Cell Assay Kits OriGene siRNA for CGREF1 OriGene 3'-UTR Clone for CGREF1 OriGene untagged cDNA clones in CMV expression vector in human , mouse , rat for CGREF1 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human , mouse , rat for CGREF1 Browse OriGene GFP tagged cDNA clones in CMV expression vector Browse OriGene MicroRNA Expression Plasmids Browse OriGene basic RS shRNAs Browse OriGene validated miRNA SYBR primer pairs OriGene Purified Protein for CGREF1 OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling OriGene Custom Antibody Services for CGREF1 OriGene Custom Protein Services for CGREF1 OriGene Custom Immunoassay Development
QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CGREF1 QIAGEN SeqTarget long-range PCR primers in human , mouse , rat for resequencing CGREF1 QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CGREF1 QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human , mouse , rat CGREF1 QIAGEN QuantiFast Probe-based Assays in human , mouse , rat CGREF1 QIAGEN QuantiTect SYBR Green Assays in human , mouse , rat CGREF1
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CGREF1 Proteins, Antibodies, CLIAs, and ELISAs
Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGREF1
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Vector BioLabs ready-to-use adenovirus/AAV for human , mouse , rat CGREF1
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