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CGNL1 Gene

protein-coding   GIFtS: 54
GCID: GC15P057668

Cingulin-Like 1

  See CGNL1-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cingulin-Like 11 2     Cingulin-Like Protein 12
Junction-Associated Coiled-Coil Protein2 3     paracingulin2
JACOP2 3     Paracingulin3
KIAA17493 5     FLJ149575

External Ids:    HGNC: 259311   Entrez Gene: 849522   Ensembl: ENSG000001288497   OMIM: 6078565   UniProtKB: Q0VF963   

Export aliases for CGNL1 gene to outside databases

Previous GC identifers: GC15P055456 GC15P034553


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CGNL1 Gene:
This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight
cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small
GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this
gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants
have been observed for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for CGNL1 Gene:
CGNL1 (cingulin-like 1) is a protein-coding gene. Diseases associated with CGNL1 include estrogen excess, and aromatase excess syndrome. GO annotations related to this gene include motor activity. An important paralog of this gene is CGN.

UniProtKB/Swiss-Prot: CGNL1_HUMAN, Q0VF96
Function: May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based
cytoskeletons (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000015.9  NT_010194.18  NC_018926.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CGNL1 gene promoter:
         C/EBPbeta   Pax-2   Pax-2a   Tal-1beta   E47   AREB6   deltaCREB   Cart-1   Chx10   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCGNL1 promoter sequence
   Search Chromatin IP Primers for CGNL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CGNL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.3   Ensembl cytogenetic band:  15q21.3   HGNC cytogenetic band: 15q21.3

CGNL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CGNL1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P057668:  view genomic region     (about GC identifiers)

Start:
57,668,165 bp from pter      End:
57,842,925 bp from pter
Size:
174,761 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CGNL1_HUMAN, Q0VF96 (See protein sequence)
Recommended Name: Cingulin-like protein 1  
Size: 1302 amino acids; 149079 Da
Subunit: Homodimer or oligomer (By similarity)
Sequence caution: Sequence=AAH30995.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: Q05BZ4 Q52LR0 Q695C7 Q7Z2L3 Q96JV2 Q96MN6 Q9C0B4
Alternative splicing: 2 isoforms:  Q0VF96-1   Q0VF96-2   

Explore the universe of human proteins at neXtProt for CGNL1: NX_Q0VF96

Explore proteomics data for CGNL1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys525, Lys681
  • Modification sites at PhosphoSitePlus

  • See CGNL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001239264.1  NP_116255.2  

    ENSEMBL proteins: 
     ENSP00000281282  

    CGNL1 Human Recombinant Protein Products:

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    antibodies-online peptides for CGNL1

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    antibodies-online antibodies for CGNL1 (10 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002928 Myosin_tail

    Graphical View of Domain Structure for InterPro Entry Q0VF96

    ProtoNet protein and cluster: Q0VF96

    UniProtKB/Swiss-Prot: CGNL1_HUMAN, Q0VF96
    Domain: The head region is responsible for junction-based distribution (By similarity)
    Similarity: Belongs to the cingulin family


    Find genes that share domains with CGNL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CGNL1_HUMAN, Q0VF96
    Function: May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based
    cytoskeletons (By similarity)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
         
    Find genes that share ontologies with CGNL1           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CGNL1:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CGNL1
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    miRTarBase miRNAs that target CGNL1:
    hsa-mir-215-5p (MIRT024620), hsa-mir-335-5p (MIRT018735), hsa-mir-125a-5p (MIRT045751), hsa-mir-192-5p (MIRT026805), hsa-mir-744-5p (MIRT037512), hsa-mir-130b-5p (MIRT038313)

    Block miRNA regulation of human, mouse, rat CGNL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CGNL1 (see all 28):
    hsa-miR-148b* hsa-let-7d hsa-miR-520d-5p hsa-miR-488 hsa-let-7c hsa-miR-219-5p hsa-miR-3133 hsa-miR-29b-1*
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CGNL1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CGNL1_HUMAN, Q0VF96: Cell junction, tight junction (By similarity). Note=Localizes to the apical junction complex
    composed of tight and adherens junctions (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    nucleus3
    cytoskeleton2
    cytosol2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005923tight junction IEA--
    GO:0015629actin cytoskeleton ----
    GO:0016459myosin complex IEA--
    GO:0043296apical junction complex ----

    Find genes that share ontologies with CGNL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CGNL1
    Interactions:

        Search GeneGlobe Interaction Network for CGNL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CGNL1 (Q0VF963 ENSP000002812824) via UniProtKB, MINT, STRING, and/or I2D (see all 39)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APCP250543, ENSP000002574304I2D: score=3 STRING: ENSP00000257430
    YWHAEP622583, ENSP000002643354I2D: score=3 STRING: ENSP00000264335
    YWHAGP619813, ENSP000003063304I2D: score=3 STRING: ENSP00000306330
    YWHAZP631043, ENSP000003095034I2D: score=2 STRING: ENSP00000309503
    WNK1Q9H4A33, ENSP000003130594I2D: score=1 STRING: ENSP00000313059
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CGNL1



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CGNL1 gene (2 alternative transcripts): 
    NM_001252335.1  NM_032866.4  

    Unigene Cluster for CGNL1:

    Cingulin-like 1
    Hs.148989  [show with all ESTs]
    Unigene Representative Sequence: NM_001252335
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559194 ENST00000281282(uc010bfw.3 uc002aeg.3) ENST00000557813(uc002aeh.3)

    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CGNL1 (see all 28):
    hsa-miR-148b* hsa-let-7d hsa-miR-520d-5p hsa-miR-488 hsa-let-7c hsa-miR-219-5p hsa-miR-3133 hsa-miR-29b-1*
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    OriGene qSTAR qPCR primer pairs in human, mouse for CGNL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CGNL1
      QuantiTect SYBR Green Assays in human, mouse, rat CGNL1
      QuantiFast Probe-based Assays in human, mouse, rat CGNL1

    Additional mRNA sequence: 

    AB051536.2 AK027025.1 AK027863.1 AK056673.1 AK307410.1 AL110171.1 AY274808.1 AY610514.1 
    BC021799.1 BC030995.1 BC062770.1 BC093827.1 BC112049.1 BC118918.1 BC118919.1 

    3 DOTS entries:

    DT.115309  DT.100672418  DT.95264972 

    Selected AceView cDNA sequences (see all 118):

    BC021799 AI467921 AW850124 AY274808 AA678787 AA595322 AI685849 AI493329 
    BU687691 BQ018491 BX102494 AA205737 BF057380 CB269228 AA778107 NM_032866 
    AA913116 AW136348 AK056673 BM705309 AA782165 CK430250 BM706094 BQ649026 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CGNL1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:              -     -           -                                                                                                                           
    SP4:              -     -     -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for CGNL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CGNL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGTGAATT
    CGNL1 Expression
    About this image


    CGNL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 11) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 3 entries
             Human embryonic stem cells (family)
     
     Heart (Cardiovascular System)    fully expand to see all 2 entries
             Cushion Mesenchymal Cells Endocardium
     
     Bone (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
     
     Cartilage (Muscoskeletal System)
             HyStem+TGFbeta3+GDF5-induced 7SMOO32 cells
     
     Umbilical Cord (Extraembryonic Tissues)
             Wharton's jelly-derived stem cells
    CGNL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CGNL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.148989

    UniProtKB/Swiss-Prot: CGNL1_HUMAN, Q0VF96
    Tissue specificity: Smooth muscle, spleen, testis, fetal brain, amygdala, corpus callosum, cerebellum, thalamus
    and subthalamic nucleus of adult brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGNL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CGNL1 gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cgnl11 , 5 cingulin-like 11, 5 82(n)1
    82.87(a)1
      9 (39.85 cM)5
    681781  NM_026599.41  NP_080875.31 
     716265095 
    chicken
    (Gallus gallus)
    Aves CGNL11 cingulin-like 1 66.38(n)
    63.74(a)
      415405  XM_413790.4  XP_413790.4 
    lizard
    (Anolis carolinensis)
    Reptilia CGNL16
    cingulin-like 1
    60(a)
    1 ↔ 1
    GL343573.1(351249-373618)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.70822 Xenopus laevis transcribed sequence with weak similarity more 75.08(n)    BJ058476.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cgnl11 cingulin-like 1 58.26(n)
    53.38(a)
      553350  XM_003198999.2  XP_003199047.1 


    ENSEMBL Gene Tree for CGNL1 (if available)
    TreeFam Gene Tree for CGNL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CGNL1 gene
    CGN2  
    1 SIMAP similar gene for CGNL1 using alignment to 2 protein entries:     CGNL1_HUMAN (see all proteins):
    CGN

    Find genes that share paralogs with CGNL1           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CGNL1 (see all 4724)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1445015421,2
    Cuntested137793740(+) CCTCCC/TTTGGT 4 L F mis11Minor allele frequency- T:0.00NA 4550
    rs2020939401,2
    --34500535(+) TAAAC-/TTTA  
            
    TTTTC
    1 -- int10--------
    rs16644631,2
    C,A--34500538(-) GAAAAG/TAAAGT 1 -- int16Minor allele frequency- T:0.00NA CSA 10
    rs1430700471,2
    C--34500540(+) TTTAT-/TTTC  
            
    TTTCT
    1 -- int10--------
    rs58128911,2
    C--34505764(+) AACCT-/CCCACC 1 -- int11Minor allele frequency- C:0.00NA 2
    rs58128921,2
    C--34507838(+) TCTTT-/CCCCCC 1 -- int1 trp30--------
    rs105327521,2
    C--34515863(+) ATACC-/T/TT  
            
    TTTTT
    1 -- int11CSA 2
    rs2018359441,2
    C--34515864(+) ATACC-/TTTTTTT 1 -- int10--------
    rs360603821,2
    C--34521537(+) TCCTT-/C/C   
      TT
    /TTC
    TTTCT
    3 -- int1 cds10--------
    rs1129005951,2
    F--34527329(+) TACCAA/GGTTCA 1 -- int11Minor allele frequency- G:0.00CSA 1

    HapMap Linkage Disequilibrium report for CGNL1 (57668165 - 57842925 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CGNL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2454508CNV Deletion19546169
    nsv904255CNV Loss21882294
    nsv904254CNV Gain21882294
    nsv457166CNV Gain19166990
    nsv833021CNV Gain17160897
    esv2751536CNV Gain17911159
    dgv2387n71CNV Gain21882294
    nsv833022CNV Gain17160897
    nsv516366CNV Gain+Loss19592680
    nsv7266OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 607856    OMIM disorders: --

    UniProtKB/Swiss-Prot: CGNL1_HUMAN, Q0VF96
  • Aromatase excess syndrome (AEXS) [MIM:139300]: An autosomal dominant disorder characterized by increased
    extraglandular aromatization of steroids that presents with heterosexual precocity in males and isosexual
    precocity in females. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal
    aberration inv(15)(q21.2;q21.3) has been found in patients with aromatase excess syndrome. The inversion moves
    the promoter of the CGNL1 gene into a 5-prime position in relation to the aromatase coding region

  • 2 diseases for CGNL1:    
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    estrogen excess    aromatase excess syndrome

    1 disease from the University of Copenhagen DISEASES database for CGNL1:
    Gynecomastia

    Find genes that share disorders with CGNL1           About GenesLikeMe

    Genetic Association Database (GAD): CGNL1

    Export disorders for CGNL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CGNL1 gene, integrated from 10 sources (see all 16):
    (articles sorted by number of sources associating them with CGNL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (DNA Res. 2000)
    2. Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder. (PubMed id 21305692)1, 4 Belmonte Mahon P....Zandi P.P. (Am. J. Med. Genet. B Neuropsychiatr. Genet. 2011)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. Estrogen excess associated with novel gain-of-function mutations affecting the aromatase gene. (PubMed id 12736278)1, 2 Shozu M.... Bulun S.E. (N. Engl. J. Med. 2003)
    5. Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions. (PubMed id 18653465)1, 9 Guillemot L....Citi S. (Mol. Biol. Cell 2008)
    6. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (Sci. Signal. 2011)
    8. A role for ZO-1 and PLEKHA7 in recruiting paracingulin to tight and adherens junctions of epithelial cells. (PubMed id 21454477)1 Pulimeno P....Citi S. (J. Biol. Chem. 2011)
    9. Comparative proteomic analysis identifies a role for SUMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (Sci Signal 2011)
    10. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (Nat. Methods 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 84952 HGNC: 25931 AceView: FLJ14957 Ensembl:ENSG00000128849 euGenes: HUgn84952
    ECgene: CGNL1 H-InvDB: CGNL1

    (According to HUGE)
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    HUGE: KIAA1749

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CGNL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CGNL1 gene:
    Search GeneIP for patents involving CGNL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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