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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CGNL1 Gene

protein-coding   GIFtS: 50
GCID: GC15P057668

cingulin-like 1
 Explore 5 diseases affiliated with
CGNL1 via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CGNL1    

Aliases
for CGNL1 gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cingulin-Like 11 2     Junction-Associated Coiled-Coil Protein2 3
JACOP1 2 3     FLJ149571 5
KIAA17491 3 5     Cingulin-Like Protein 12
Paracingulin3     Paracingulin3

External Ids:    HGNC: 259311   Entrez Gene: 849522   Ensembl: ENSG000001288497   OMIM: 6078565   UniProtKB: Q0VF963   

Export aliases for CGNL1 gene to outside databases

Previous GC identifers: GC15P055456 GC15P034553


Summaries
for CGNL1 gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
Entrez Gene summary for CGNL1:
This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight cell-cell
junctions and mediates junction assembly and maintenance by regulating the activity of the small GTPases RhoA and
Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this gene with the
aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants have been observed
for this gene. (provided by RefSeq, Nov 2011)

UniProtKB/Swiss-Prot: CGNL1_HUMAN, Q0VF96
Function: May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based
cytoskeletons (By similarity)




Genomic Views
for CGNL1 gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NC_018926.1  NT_010194.17  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CGNL1 gene promoter:
         C/EBPbeta   Pax-2   Pax-2a   Tal-1beta   E47   AREB6   deltaCREB   Cart-1   Chx10   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CGNL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CGNL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CGNL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.3   Ensembl cytogenetic band:  15q21.3   HGNC cytogenetic band: 15q21.3

CGNL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CGNL1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P057668:  view genomic region     (about GC identifiers)

Start:
 57,668,165 bp from pter      End:
 57,842,925 bp from pter
Size:
 174,761 bases      Orientation:
 plus strand

Proteins
for CGNL1 gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CGNL1_HUMAN, Q0VF96 (See protein sequence)
Recommended Name: Cingulin-like protein 1  
Size: 1302 amino acids; 149079 Da
Subunit: Homodimer or oligomer (By similarity)
Subcellular location: Cell junction, tight junction (By similarity). Note=Localizes to the apical junction complex
composed of tight and adherens junctions (By similarity)
Sequence caution: Sequence=AAH30995.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A
sequence;
Secondary accessions: Q05BZ4 Q52LR0 Q695C7 Q7Z2L3 Q96JV2 Q96MN6 Q9C0B4
Alternative splicing: 2 isoforms:  Q0VF96-1   Q0VF96-2   

Explore the universe of human proteins at neXtProt for CGNL1: NX_Q0VF96

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q0VF96

    • CGNL1 Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins (2 alternative transcripts): 
    NP_001239264.1  NP_116255.2  

    ENSEMBL proteins: 
     ENSP00000281282  

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    Uscn Proteins for CGNL1

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005923tight junction IEA--
    GO:0015629actin cytoskeleton ----
    GO:0016459myosin complex IEA--
    GO:0043296apical junction complex ----


    CGNL1 for ontologies           About GeneDecksing



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    Protein Domains /
    Families
    for CGNL1 gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CGNL1 for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002928 Myosin_tail

    Graphical View of Domain Structure for InterPro Entry Q0VF96

    ProtoNet protein and cluster: Q0VF96

    UniProtKB/Swiss-Prot: CGNL1_HUMAN, Q0VF96
    Domain: The head region is responsible for junction-based distribution (By similarity)
    Similarity: Belongs to the cingulin family


    Function
    for CGNL1 gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CGNL1_HUMAN, Q0VF96
    Function: May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based
    cytoskeletons (By similarity)

    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate CGNL1 (see all 28):
    hsa-miR-148b* hsa-let-7d hsa-miR-520d-5p hsa-miR-488 hsa-let-7c hsa-miR-219-5p hsa-miR-3133 hsa-miR-29b-1*
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    OriGene shRNA RFP: CGNL1
    OriGene siRNA: CGNL1
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    Gene Editing
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    Clone
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    Search LifeMap BioReagents cell lines for CGNL1

    In Situ Assay
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    Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--


    CGNL1 for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CGNL1:
     G0/1 arrest  Increased G1 DNA content 


    Pathways & Interactions
    for CGNL1 gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CGNL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for CGNL1 (Q0VF963 ENSP000002812824) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APCP250543, ENSP000002574304I2D: score=3 STRING: ENSP00000257430
    YWHAEP622583, ENSP000002643354I2D: score=3 STRING: ENSP00000264335
    YWHAGP619813, ENSP000003063304I2D: score=3 STRING: ENSP00000306330
    YWHAZP631043, ENSP000003095034I2D: score=2 STRING: ENSP00000309503
    WNK1Q9H4A33, ENSP000003130594I2D: score=1 STRING: ENSP00000313059
    About this table

    Drugs & Compounds
    for CGNL1 gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CGNL1
    Search CenterWatch for drugs/clinical trials and news about CGNL1 

    Transcripts
    for CGNL1 gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CGNL1 gene (2 alternative transcripts): 
    NM_001252335.1  NM_032866.4  

    Unigene Cluster for CGNL1:

    Cingulin-like 1
    Hs.148989  [show with all ESTs]
    Unigene Representative Sequence: NM_001252335
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559194 ENST00000281282(uc010bfw.3 uc002aeg.3) ENST00000557813(uc002aeh.3)


    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate CGNL1 (see all 28):
    hsa-miR-148b* hsa-let-7d hsa-miR-520d-5p hsa-miR-488 hsa-let-7c hsa-miR-219-5p hsa-miR-3133 hsa-miR-29b-1*
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
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    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CGNL1 (see all 7)
    OriGene shRNA RFP: CGNL1
    OriGene siRNA: CGNL1
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CGNL1
    Clone
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    Primer
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    Additional cDNA sequence: 

    AB051536.2 AK027025.1 AK027863.1 AK056673.1 AK307410.1 AL110171.1 AY274808.1 AY610514.1 
    BC021799.1 BC030995.1 BC062770.1 BC093827.1 BC112049.1 BC118918.1 BC118919.1 

    3 DOTS entries:

    DT.115309  DT.100672418  DT.95264972 

    24/118 AceView cDNA sequences (see all 118):

    BX102494 AI493329 AI685849 AW850124 BF057380 AA913116 AA205737 AA678787 
    BC021799 AA595322 NM_032866 BQ018491 CB269228 AA778107 AI467921 AY274808 
    BU687691 BE161738 BQ694494 AI635664 CK430250 BM706094 AW873580 AA205724 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CGNL1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:              -     -           -                                                                                                                           
    SP4:              -     -     -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for CGNL1

    Expression
    for CGNL1 gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CGNL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGAGTGAATT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CGNL1 expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartEndocardiumEndocardial Tube CellsEndocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 10 LifeMap Cells 
    NameCategory
    PureStem™ endothelial progenitor 30-MV2-12 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial Progenitor 30-SM2-3 (Embryonic Progenitor Cell)Blood, Endothelium
    PureStem™ endothelial progenitor 30-SM2-1 (Embryonic Progenitor Cell)Endothelium
    PureStem™ endothelial progenitor RP1-MV2-18 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor E68 (Embryonic Progenitor Cell)
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    PureStem™ endothelial progenitor 30-MV2-14 (Embryonic Progenitor Cell)Endothelium
    PureStem™ progenitor T36 (Embryonic Progenitor Cell)
    Midbrain dopaminergic-like neurons (Generation of midbra...)
    Definitive endoderm-like cells (A scalable, suspensi...)

    See CGNL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CGNL1

    SOURCE GeneReport for Unigene cluster: Hs.148989

    UniProtKB/Swiss-Prot: CGNL1_HUMAN, Q0VF96
    Tissue specificity: Smooth muscle, spleen, testis, fetal brain, amygdala, corpus callosum, cerebellum, thalamus and
    subthalamic nucleus of adult brain

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    In Situ
    Assay Products:     
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    Orthologs
    for CGNL1 gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CGNL1 gene from 7/19 species (see all 19)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    mouse
    (Mus musculus)    		 Mammalia Cgnl11 , 5 cingulin-like 11, 5 81.94(n)1
    82.95(a)1    		   9 (39.85 cM)5
    681781  NM_026599.41  NP_080875.31 
     716265095 
    chicken
    (Gallus gallus)    		 Aves CGNL11 cingulin-like 1 65.88(n)
    63.85(a)    		   415405  XM_413790.3  XP_413790.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CGNL16
    --
    		 --
    		 61(a)
    26(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343573.1(351249-373618)
    GL343680.1(160971-163659)
    African clawed frog
    (Xenopus laevis)    		 Amphibia Xl.70822 Xenopus laevis transcribed sequence with weak similarity more 75.08(n)    BJ058476.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii cgnl11 cingulin-like 1 56.93(n)
    51.74(a)    		   553350  XM_003198999.1  XP_003199047.1 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Prm6
    		 Paramyosin
    		 16(a)
    		 possible ortholog
    		 3L(8725958-8738410)
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-156
    		 Paramyosin
    		 16(a)
    		 possible ortholog
    		 I(7376601-7383194)


    ENSEMBL Gene Tree for CGNL1 (if available)
    TreeFam Gene Tree for CGNL1 (if available) 

    Paralogs
    for CGNL1 gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CGNL1 gene
    CGN2  CCDC102A2  CCDC102B2  
    1 SIMAP similar gene for CGNL1 using alignment to 2 protein entries:     CGNL1_HUMAN (see all proteins):
    CGN

    CGNL1 for paralogs           About GeneDecksing



    Genomic Variants
    for CGNL1 gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4069 NCBI SNPs in CGNL1 are shown (see all 4069)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 15 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1445015421,2
    		Cother67826752(+) CCTCCC/TTTGGT 4 L F mis11Minor allele frequency- T:0.00NA 4550
    rs740161701,2
    		C,--34490584(+) TCCCCC/TATCTG 1 -- us2k11Minor allele frequency- T:0.50WA 2
    rs734195001,2
    		C,F,--34490612(+) GGTGCC/TCTCTA 1 -- us2k13Minor allele frequency- T:0.11WA 122
    rs762239861,2
    		C,F,--34490783(+) GCAGCC/TTCTGC 1 -- us2k11Minor allele frequency- T:0.07NA 120
    rs790784461,2
    		F,--34490866(+) CCTGCT/CAACTC 1 -- us2k11Minor allele frequency- C:0.04WA 118
    rs22558711,2
    		C--34491466(+) AAAGTA/CCAGGT 1 -- us2k11Minor allele frequency- C:0.00NA 2
    rs18144821,2
    		C,--34491695(-) GTAAAG/CTGAGG 1 -- us2k13Minor allele frequency- C:0.07CSA WA NA 240
    rs775460051,2
    		C,F,--34491781(+) TAGGTG/ACTCAA 1 -- us2k11Minor allele frequency- A:0.07NA 120
    rs753375311,2
    		--34491788(+) TCAATA/GAATAG 1 -- us2k11Minor allele frequency- G:0.01WA 118
    rs784437951,2
    		C,F,--34491818(+) GAAGAG/ACGCTA 1 -- us2k11Minor allele frequency- A:0.07NA 120

    HapMap Linkage Disequilibrium report for CGNL1 (57668165 - 57842925 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
    Database of Genomic Variants (DGV): 6 variations for CGNL1
         6 CNVs: 49570 8799 102108 49569 4902 34472

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    Disorders / Diseases
    for CGNL1 gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CGNL1 for disorders           About GeneDecksing

    OMIM gene information: 607856    OMIM disorders: --

    UniProtKB/Swiss-Prot: CGNL1_HUMAN, Q0VF96
  • Defects in CGNL1 are a cause of aromatase excess syndrome (AEXS) [MIM:139300]. A disorder characterized by an
    • estrogen excess due to an increased aromatase activity. Note=A chromosomal aberration inv(15)(q21.2;q21.3) has been
    found in patients with aromatase excess syndrome. The inversion moves the promoter of the CGNL1 gene into a 5-prime
    position in relation to the aromatase coding region

    5 diseases for CGNL1:    About MalaCards
    aromatase excess syndrome    estrogen excess    corpus callosum    gynecomastia
    bipolar disorder

    1 disease from the University of Copenhagen DISEASES database for CGNL1:
    Gynecomastia

    Export disorders for CGNL1 gene to outside databases

    Publications
    for CGNL1 gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CGNL1 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with CGNL1)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Estrogen excess associated with novel gain-of-function mutations affecting the aromatase gene. (PubMed id 12736278)1, 2 Shozu M.... Bulun S.E. (2003)
    4. Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions. (PubMed id 18653465)1, 9 Guillemot L....Citi S. (2008)
    5. Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder. (PubMed id 21305692)1 Belmonte Mahon P....Zandi P.P. (2011)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    8. A role for ZO-1 and PLEKHA7 in recruiting paracinguli n to tight and adherens junctions of epithelial cells. (PubMed id 21454477)1 Pulimeno P....Citi S. (2011)
    9. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
    10. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)

    External Searches for CGNL1 gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CGNL1 gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84952 HGNC: 25931 AceView: FLJ14957 Ensembl:ENSG00000128849 euGenes: HUgn84952
    ECgene: CGNL1 H-InvDB: CGNL1

    Other Databases showing CGNL1 gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1749

    Specialized Databases showing CGNL1 gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CGNL1 Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CGNL1 gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CGNL1 gene:
    Search GeneIP for patents involving CGNL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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