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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CGNL1 Gene

protein-coding   GIFtS: 53
GCID: GC15P057668

Cingulin-Like 1

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cingulin-Like 11 2     Cingulin-Like Protein 12
Junction-Associated Coiled-Coil Protein2 3     paracingulin2
JACOP2 3     Paracingulin3
KIAA17493 5     FLJ149575

External Ids:    HGNC: 259311   Entrez Gene: 849522   Ensembl: ENSG000001288497   OMIM: 6078565   UniProtKB: Q0VF963   

Export aliases for CGNL1 gene to outside databases

Previous GC identifers: GC15P055456 GC15P034553


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CGNL1 Gene:
This gene encodes a member of the cingulin family. The encoded protein localizes to both adherens and tight
cell-cell junctions and mediates junction assembly and maintenance by regulating the activity of the small
GTPases RhoA and Rac1. Heterozygous chromosomal rearrangements resulting in association of the promoter for this
gene with the aromatase gene are a cause of aromatase excess syndrome. Alternatively spliced transcript variants
have been observed for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for CGNL1 Gene: 
CGNL1 (cingulin-like 1) is a protein-coding gene. Diseases associated with CGNL1 include estrogen excess, and aromatase excess syndrome. GO annotations related to this gene include motor activity. An important paralog of this gene is CGN.

UniProtKB/Swiss-Prot: CGNL1_HUMAN, Q0VF96
Function: May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based
cytoskeletons (By similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000015.9  NT_010194.17  NC_018926.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CGNL1 gene promoter:
         C/EBPbeta   Pax-2   Pax-2a   Tal-1beta   E47   AREB6   deltaCREB   Cart-1   Chx10   LyF-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCGNL1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CGNL1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CGNL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 15q21.3   Ensembl cytogenetic band:  15q21.3   HGNC cytogenetic band: 15q21.3

CGNL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CGNL1 gene location

GeneLoc information about chromosome 15         GeneLoc Exon Structure

GeneLoc location for GC15P057668:  view genomic region     (about GC identifiers)

Start:
57,668,165 bp from pter      End:
57,842,925 bp from pter
Size:
174,761 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CGNL1_HUMAN, Q0VF96 (See protein sequence)
Recommended Name: Cingulin-like protein 1  
Size: 1302 amino acids; 149079 Da
Subunit: Homodimer or oligomer (By similarity)
Subcellular location: Cell junction, tight junction (By similarity). Note=Localizes to the apical junction complex
composed of tight and adherens junctions (By similarity)
Sequence caution: Sequence=AAH30995.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential
poly-A sequence;
Secondary accessions: Q05BZ4 Q52LR0 Q695C7 Q7Z2L3 Q96JV2 Q96MN6 Q9C0B4
Alternative splicing: 2 isoforms:  Q0VF96-1   Q0VF96-2   

Explore the universe of human proteins at neXtProt for CGNL1: NX_Q0VF96

Explore proteomics data for CGNL1 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q0VF96

  • CGNL1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CGNL1 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_001239264.1  NP_116255.2  

    ENSEMBL proteins: 
     ENSP00000281282  

    Human Recombinant Protein Products for CGNL1: 
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    Cloud-Clone Corp. Proteins for CGNL1 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005923tight junction IEA--
    GO:0015629actin cytoskeleton ----
    GO:0016459myosin complex IEA--
    GO:0043296apical junction complex ----

    CGNL1 for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR002928 Myosin_tail

    Graphical View of Domain Structure for InterPro Entry Q0VF96

    ProtoNet protein and cluster: Q0VF96

    UniProtKB/Swiss-Prot: CGNL1_HUMAN, Q0VF96
    Domain: The head region is responsible for junction-based distribution (By similarity)
    Similarity: Belongs to the cingulin family


    CGNL1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CGNL1_HUMAN, Q0VF96
    Function: May be involved in anchoring the apical junctional complex, especially tight junctions, to actin-based
    cytoskeletons (By similarity)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
         
    CGNL1 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CGNL1:
     G0/1 arrest  Increased G1 DNA content 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CGNL1 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CGNL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CGNL1 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CGNL1 

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    hsa-miR-148b* hsa-let-7d hsa-miR-520d-5p hsa-miR-488 hsa-let-7c hsa-miR-219-5p hsa-miR-3133 hsa-miR-29b-1*
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CGNL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    5/7 Interacting proteins for CGNL1 (Q0VF963 ENSP000002812824) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    APCP250543, ENSP000002574304I2D: score=3 STRING: ENSP00000257430
    YWHAEP622583, ENSP000002643354I2D: score=3 STRING: ENSP00000264335
    YWHAGP619813, ENSP000003063304I2D: score=3 STRING: ENSP00000306330
    YWHAZP631043, ENSP000003095034I2D: score=2 STRING: ENSP00000309503
    WNK1Q9H4A33, ENSP000003130594I2D: score=1 STRING: ENSP00000313059
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CGNL1

    Search CenterWatch for drugs/clinical trials and news about CGNL1

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CGNL1 gene (2 alternative transcripts): 
    NM_001252335.1  NM_032866.4  

    Unigene Cluster for CGNL1:

    Cingulin-like 1
    Hs.148989  [show with all ESTs]
    Unigene Representative Sequence: NM_001252335
    3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000559194 ENST00000281282(uc010bfw.3 uc002aeg.3) ENST00000557813(uc002aeh.3)

    miRNA
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    8/28 QIAGEN miScript miRNA Assays for microRNAs that regulate CGNL1 (see all 28):
    hsa-miR-148b* hsa-let-7d hsa-miR-520d-5p hsa-miR-488 hsa-let-7c hsa-miR-219-5p hsa-miR-3133 hsa-miR-29b-1*
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    Inhib. RNA
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CGNL1

    Additional mRNA sequence: 

    AB051536.2 AK027025.1 AK027863.1 AK056673.1 AK307410.1 AL110171.1 AY274808.1 AY610514.1 
    BC021799.1 BC030995.1 BC062770.1 BC093827.1 BC112049.1 BC118918.1 BC118919.1 

    3 DOTS entries:

    DT.115309  DT.100672418  DT.95264972 

    24/118 AceView cDNA sequences (see all 118):

    AA205737 BQ018491 AA778107 AY274808 AA678787 BX102494 AI467921 BU687691 
    NM_032866 AW850124 CB269228 BC021799 BF057380 AI685849 AA595322 AA913116 
    AI493329 AL110171 AW873580 CK430250 AA142981 AI635664 AA782165 BG426971 

    GeneLoc Exon Structure

    5/7 Alternative Splicing Database (ASD) splice patterns (SP) for CGNL1 (see all 7)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6a · 6b · 6c ^ 7 ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18 ^ 19 ^ 20 ^ 21 ^ 22 ^
    SP1:                                                                                                                                                            
    SP2:                                                                                                                                                            
    SP3:              -     -           -                                                                                                                           
    SP4:              -     -     -                                                                                                                                 
    SP5:                                                                                                                                                            

    ExUns: 23 ^ 24
    SP1:            
    SP2:            
    SP3:            
    SP4:            
    SP5:            


    ECgene alternative splicing isoforms for CGNL1

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CGNL1 expression in normal human tissues (normalized intensities)      CGNL1 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGAGTGAATT
    CGNL1 Expression
    About this image


    CGNL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/20 selected tissues (see all 20) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 11 entries
             PureStem endothelial progenitor 30-SM2-1
             Human Renal Glomerular Endothelial Cells (HRGEC)   
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 6 entries
             C2a
             ESI-017   
     
     Umbilical Cord (Extraembryonic Tissues)    fully expand to see all 4 entries
             Wharton's jelly-derived stem cells
             Human Umbilical Vein Endothelial Cells (HUVEC) (ScienceCell)   
     
     Kidney (Urinary System)    fully expand to see all 3 entries
             Human Renal Mesangial Cells (HRMC)   
     
     Eye (Sensory Organs)    fully expand to see all 2 entries
             Human Retinal Pigment Epithelial Cells (HRPEpiC)   

    See CGNL1 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CGNL1

    SOURCE GeneReport for Unigene cluster: Hs.148989

    UniProtKB/Swiss-Prot: CGNL1_HUMAN, Q0VF96
    Tissue specificity: Smooth muscle, spleen, testis, fetal brain, amygdala, corpus callosum, cerebellum, thalamus
    and subthalamic nucleus of adult brain

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGNL1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CGNL1 gene from 7/16 species (see all 16)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cgnl11 , 5 cingulin-like 11, 5 81.94(n)1
    82.95(a)1
      9 (39.85 cM)5
    681781  NM_026599.41  NP_080875.31 
     716265095 
    chicken
    (Gallus gallus)
    Aves CGNL11 cingulin-like 1 65.88(n)
    63.85(a)
      415405  XM_413790.3  XP_413790.3 
    lizard
    (Anolis carolinensis)
    Reptilia CGNL16
    Uncharacterized protein
    61(a)
    1 ↔ 1
    GL343573.1(351249-373618)
    African clawed frog
    (Xenopus laevis)
    Amphibia Xl.70822 Xenopus laevis transcribed sequence with weak similarity more 75.08(n)    BJ058476.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cgnl11 cingulin-like 1 56.93(n)
    51.74(a)
      553350  XM_003198999.1  XP_003199047.1 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG316386
    --
    12(a)
    1 → many
    2L(6491122-6496986)
    worm
    (Caenorhabditis elegans)
    Secernentea F53F10.16
    Protein F53F10.1
    14(a)
    1 → many
    I(3834117-3837765)


    ENSEMBL Gene Tree for CGNL1 (if available)
    TreeFam Gene Tree for CGNL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CGNL1 gene
    CGN2  
    1 SIMAP similar gene for CGNL1 using alignment to 2 protein entries:     CGNL1_HUMAN (see all proteins):
    CGN

    CGNL1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/4724 SNPs in CGNL1 are shown (see all 4724)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 15 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1445015421,2
    Cuntested137793740(+) CCTCCC/TTTGGT 4 L F mis11Minor allele frequency- T:0.00NA 4550
    rs2020939401,2
    --34500535(+) TAAAC-/TTTA  
            
    TTTTC
    1 -- int10--------
    rs16644631,2
    C,A--34500538(-) GAAAAG/TAAAGT 1 -- int16Minor allele frequency- T:0.00NA CSA 10
    rs1430700471,2
    C--34500540(+) TTTAT-/TTTC  
            
    TTTCT
    1 -- int10--------
    rs58128911,2
    C--34505764(+) AACCT-/CCCACC 1 -- int11Minor allele frequency- C:0.00NA 2
    rs58128921,2
    C--34507838(+) TCTTT-/CCCCCC 1 -- int1 trp30--------
    rs105327521,2
    C--34515863(+) ATACC-/T/TT  
            
    TTTTT
    1 -- int11CSA 2
    rs2018359441,2
    C--34515864(+) ATACC-/TTTTTTT 1 -- int10--------
    rs360603821,2
    C--34521537(+) TCCTT-/C/C   
      TT
    /TTC
    TTTCT
    3 -- int1 cds10--------
    rs1129005951,2
    F--34527329(+) TACCAA/GGTTCA 1 -- int11Minor allele frequency- G:0.00CSA 1

    HapMap Linkage Disequilibrium report for CGNL1 (57668165 - 57842925 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CGNL1:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2454508CNV Deletion19546169
    nsv904255CNV Loss21882294
    nsv904254CNV Gain21882294
    nsv457166CNV Gain19166990
    nsv833021CNV Gain17160897
    esv2751536CNV Gain17911159
    dgv2387n71CNV Gain21882294
    nsv833022CNV Gain17160897
    nsv516366CNV Gain+Loss19592680
    nsv7266OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 607856    OMIM disorders: --

    UniProtKB/Swiss-Prot: CGNL1_HUMAN, Q0VF96
  • Aromatase excess syndrome (AEXS) [MIM:139300]: An autosomal dominant disorder characterized by increased
    extraglandular aromatization of steroids that presents with heterosexual precocity in males and isosexual
    precocity in females. Note=The gene represented in this entry is involved in disease pathogenesis. A chromosomal
    aberration inv(15)(q21.2;q21.3) has been found in patients with aromatase excess syndrome. The inversion moves
    the promoter of the CGNL1 gene into a 5-prime position in relation to the aromatase coding region

  • 4 diseases for CGNL1:    About MalaCards
    estrogen excess    aromatase excess syndrome    gynecomastia    bipolar disorder

    1 disease from the University of Copenhagen DISEASES database for CGNL1:
    Gynecomastia

    CGNL1 for disorders           About GeneDecksing

    Genetic Association Database (GAD): CGNL1

    Export disorders for CGNL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CGNL1 gene, integrated from 9 sources (see all 16):
    (articles sorted by number of sources associating them with CGNL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 11214970)1, 2, 3 Nagase T.... Ohara O. (2000)
    2. Genome-wide association analysis of age at onset and psychotic symptoms in bipolar disorder. (PubMed id 21305692)1, 4 Belmonte Mahon P....Zandi P.P. (2011)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    4. Estrogen excess associated with novel gain-of-function mutations affecting the aromatase gene. (PubMed id 12736278)1, 2 Shozu M.... Bulun S.E. (2003)
    5. Paracingulin regulates the activity of Rac1 and RhoA GTPases by recruiting Tiam1 and GEF-H1 to epithelial junctions. (PubMed id 18653465)1, 9 Guillemot L....Citi S. (2008)
    6. A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (2011)
    7. System-wide temporal characterization of the proteome and phosphoproteome of human embryonic stem cell differentiation. (PubMed id 21406692)2 Rigbolt K.T....Blagoev B. (2011)
    8. A role for ZO-1 and PLEKHA7 in recruiting paracinguli n to tight and adherens junctions of epithelial cells. (PubMed id 21454477)1 Pulimeno P....Citi S. (2011)
    9. Comparative proteomic analysis identifies a role for S UMO in protein quality control. (PubMed id 21693764)1 Tatham M.H....Hay R.T. (2011)
    10. A human MAP kinase interactome. (PubMed id 20936779)1 Bandyopadhyay S....Ideker T. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Free Text  

      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 84952 HGNC: 25931 AceView: FLJ14957 Ensembl:ENSG00000128849 euGenes: HUgn84952
    ECgene: CGNL1 H-InvDB: CGNL1

    (According to HUGE)
    About This Section
    HUGE: KIAA1749

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CGNL1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CGNL1 gene:
    Search GeneIP for patents involving CGNL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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