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CGN Gene

protein-coding   GIFtS: 60
GCID: GC01P151483

Cingulin

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
cingulin1 2
KIAA13193

External Ids:    HGNC: 174291   Entrez Gene: 575302   Ensembl: ENSG000001433757   OMIM: 6094735   UniProtKB: Q9P2M73   

Export aliases for CGN gene to outside databases

Previous GC identifers: GC01P149325 GC01P147231 GC01P148258 GC01P148700 GC01P148296 GC01P149750 GC01P122861


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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GeneCards Summary for CGN Gene:
CGN (cingulin) is a protein-coding gene. GO annotations related to this gene include motor activity and actin binding. An important paralog of this gene is CGNL1.

UniProtKB/Swiss-Prot: CING_HUMAN, Q9P2M7
Function: Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular
permeability barrier

Gene Wiki entry for CGN (Cingulin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000001.10  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CGN gene promoter:
         IRF-1   HNF-4alpha2   HNF-4alpha1   CREB   E2F   E2F-1   deltaCREB   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCGN promoter sequence
   Search Chromatin IP Primers for CGN

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CGN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

CGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CGN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P151483:  view genomic region     (about GC identifiers)

Start:
151,482,986 bp from pter      End:
151,511,168 bp from pter
Size:
28,183 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CING_HUMAN, Q9P2M7 (See protein sequence)
Recommended Name: Cingulin  
Size: 1197 amino acids; 136386 Da
Subunit: Homodimer (By similarity). Interacts with TJP1/ZO-1
Sequence caution: Sequence=AAF74498.1; Type=Erroneous initiation; Sequence=AAI52446.1; Type=Erroneous initiation;
Sequence=BAA92557.1; Type=Erroneous initiation; Sequence=BAF82696.1; Type=Erroneous initiation;
Sequence=CAI16590.1; Type=Erroneous initiation; Sequence=EAW53434.1; Type=Erroneous initiation;
Secondary accessions: A6H8L3 A7MD22 Q5T386 Q9NR25
Alternative splicing: 2 isoforms:  Q9P2M7-1   Q9P2M7-2   (May be due to an intron retention)

Explore the universe of human proteins at neXtProt for CGN: NX_Q9P2M7

Explore proteomics data for CGN at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys461, Lys580, Lys658
  • Modification sites at PhosphoSitePlus

  • See CGN Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_065821.1  
    ENSEMBL proteins: 
     ENSP00000425532   ENSP00000422299   ENSP00000410836   ENSP00000271636   ENSP00000390686  
    Reactome Protein details: Q9P2M7

    CGN Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CGN
    GenScript Custom Purified and Recombinant Proteins Services for CGN
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CGN

     
    Search eBioscience for Proteins for CGN 

    CGN Antibody Products:

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    Novus Biologicals CGN Antibodies
    Abcam antibodies for CGN
    Cloud-Clone Corp. Antibodies for CGN
    ThermoFisher Antibodies for CGN
    LSBio Antibodies in human, mouse, rat for CGN

    CGN Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CGN
    Cloud-Clone Corp. CLIAs for CGN
    Search eBioscience for ELISAs for CGN 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    1 InterPro protein domain:
     IPR002928 Myosin_tail

    Graphical View of Domain Structure for InterPro Entry Q9P2M7

    ProtoNet protein and cluster: Q9P2M7

    UniProtKB/Swiss-Prot: CING_HUMAN, Q9P2M7
    Domain: Deletion of the ZO-1 interaction motif (ZIM) decreases but does not abolish colocalization with ZO-1
    Similarity: Belongs to the cingulin family


    Find genes that share domains with CGN           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CING_HUMAN, Q9P2M7
    Function: Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular
    permeability barrier

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0003779actin binding ISS--
    GO:0005515protein binding IPI11042084
         
    Find genes that share ontologies with CGN           About GenesLikeMe


    Phenotypes:
         2 GenomeRNAi human phenotypes for CGN:
     Decreased viability of wild-ty  Increased G1 DNA content 

         2 MGI mutant phenotypes (inferred from 2 alleles(MGI details for Cgn):
     digestive/alimentary  homeostasis/metabolism 

    Find genes that share phenotypes with CGN           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cgntm1.1Citi for CGN

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CGN
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CGN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CGN
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CGN

    miRNA
    Products:
        
    miRTarBase miRNAs that target CGN:
    hsa-mir-186-5p (MIRT021173), hsa-mir-125b-5p (MIRT004994), hsa-mir-19b-3p (MIRT031289)

    Block miRNA regulation of human, mouse, rat CGN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CGN (see all 19):
    hsa-miR-3910 hsa-miR-125a-5p hsa-miR-202 hsa-miR-486-3p hsa-miR-3133 hsa-miR-124 hsa-miR-125b hsa-miR-15b*
    SwitchGear 3'UTR luciferase reporter plasmidCGN 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CGN
    Predesigned siRNA for gene silencing in human, mouse, rat CGN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CGN

    Clone
    Products:
         
    OriGene clones in human, mouse for CGN (see all 7)
    OriGene ORF clones in mouse, rat for CGN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CGN (NM_006998)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CGN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CGN

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CGN
    Browse ESI BIO Cell Lines and PureStem Progenitors for CGN 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGN


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CING_HUMAN, Q9P2M7: Cell junction, tight junction (By similarity). Note=Localizes to the apical junction complex
    composed of tight and adherens junctions (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytosol3
    golgi apparatus3
    nucleus3
    plasma membrane3
    cytoskeleton2

    Gene Ontology (GO): 4 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005923tight junction NAS12529927
    GO:0016459myosin complex IEA--
    GO:0030054cell junction TAS--
    GO:0043296apical junction complex ----

    Find genes that share ontologies with CGN           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CGN About   (see all 8)  
    See pathways by source

    SuperPathSelected contained pathways About (see all per SuperPath)
    1Loss of Function of SMAD2/3 in Cancer
    Loss of Function of SMAD2/3 in Cancer0.60
    TGFBR1 KD Mutants in Cancer0.60
    Loss of Function of SMAD4 in Cancer0.60
    SMAD2/3 MH2 Domain Mutants in Cancer0.60
    TGFBR2 MSI Frameshift Mutants in Cancer0.60
    SMAD2/3 Phosphorylation Motif Mutants in Cancer0.60
    Signaling by TGF-beta Receptor Complex in Cancer0.60
    SMAD4 MH2 Domain Mutants in Cancer0.60
    2Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    3Signaling by GPCR
    Signal Transduction0.58
    4Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Tight junctions0.33
    5Tight junction
    Tight junction


    Find genes that share SuperPaths with CGN           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CGN
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions

    3 GeneGo (Thomson Reuters) Pathways for CGN
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Tight junctions
    Cell adhesion Gap junctions

    1 Reactome Pathway for CGN
        TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)


    1 Kegg Pathway  (Kegg details for CGN):
        Tight junction

        Pathway & Disease-focused RT2 Profiler PCR Array including CGN: 
              Tight Junctions in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CGN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CGN (Q9P2M72, 3 ENSP000002716364) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50356 I2D: score=4 STRING: ENSP00000306330
    SFNP319472, 3MINT-3974952 I2D: score=2 
    YWHAZP631042, 3, ENSP000003095034MINT-3318838 I2D: score=1 STRING: ENSP00000309503
    TJP1Q071573, ENSP000002815374I2D: score=4 STRING: ENSP00000281537
    ARHGEF2Q929743, ENSP000003153254I2D: score=2 STRING: ENSP00000315325
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0008150biological_process ND--

    Find genes that share ontologies with CGN           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CGN (CING)

    4 Novoseek inferred chemical compound relationships for CGN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    biotin 30.6 1 10940624 (1)
    calcium 22.2 8 7593331 (3), 1556151 (1), 19176351 (1)
    cycloheximide 20.2 1 15634758 (1)
    serine 10.5 1 7593331 (1)



    Find genes that share compounds with CGN           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CGN gene: 
    NM_020770.2  

    Unigene Cluster for CGN:

    Cingulin
    Hs.591464  [show with all ESTs]
    Unigene Representative Sequence: BC146657
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505188 ENST00000502442 ENST00000427934 ENST00000271636(uc009wmw.3)
    ENST00000416743 ENST00000464886 ENST00000473377(uc010pde.2) ENST00000467998

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CGN using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CGN (see all 19):
    hsa-miR-3910 hsa-miR-125a-5p hsa-miR-202 hsa-miR-486-3p hsa-miR-3133 hsa-miR-124 hsa-miR-125b hsa-miR-15b*
    SwitchGear 3'UTR luciferase reporter plasmidCGN 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CGN
    Predesigned siRNA for gene silencing in human, mouse, rat CGN
    Clone
    Products:
         
    OriGene clones in human, mouse for CGN (see all 7)
    OriGene ORF clones in mouse, rat for CGN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CGN (NM_006998)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CGN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CGN
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CGN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CGN
      QuantiTect SYBR Green Assays in human, mouse, rat CGN
      QuantiFast Probe-based Assays in human, mouse, rat CGN

    Additional mRNA sequence: 

    AB037740.1 AF263462.1 AK290007.1 BC146657.1 BC150604.1 BC152445.1 BX647343.1 DQ656045.2 
    DQ656046.2 

    6 DOTS entries:

    DT.441586  DT.101975686  DT.100818183  DT.121448827  DT.121448820  DT.40125203 

    Selected AceView cDNA sequences (see all 144):

    AI669161 BM352988 BX095062 AA394274 BU785515 BM981727 CK821947 AA988451 
    BE218913 AW445027 AA960974 AW630295 AA293711 BE467550 AA480171 AI698733 
    AA872166 AI689104 AB037740 BM352700 AI302109 CB241818 CB156995 BM069563 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CGN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCCAACTT
    CGN Expression
    About this image


    CGN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Heart (Cardiovascular System)
             Atrioventricular Canal Cells Atrioventricular Canal
     
     Ovary (Reproductive System)
             Oviduct
     
     Epidermis (Integumentary System)
    CGN Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CGN Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.591464

    UniProtKB/Swiss-Prot: CING_HUMAN, Q9P2M7
    Tissue specificity: Localized on the cytoplasmic face of tight junctions of polarized epithelia and some
    endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart

        Pathway & Disease-focused RT2 Profiler PCR Array including CGN: 
              Tight Junctions in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CGN
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CGN
    QuantiTect SYBR Green Assays in human, mouse, rat CGN
    QuantiFast Probe-based Assays in human, mouse, rat CGN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CGN gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cgn1 , 5 cingulin1, 5 85.7(n)1
    87.07(a)1
      3 (40.74 cM)5
    707371  NM_001037711.21  NP_001032800.21 
     947600695 
    chicken
    (Gallus gallus)
    Aves CGN1 cingulin 63.29(n)
    56.88(a)
      425665  XM_004948381.1  XP_004948438.1 
    African clawed frog
    (Xenopus laevis)
    Amphibia AF207901.12   -- 77.3(n)    AF207901.1 
    zebrafish
    (Danio rerio)
    Actinopterygii cgnb1 cingulin b 49.89(n)
    40.32(a)
      100005752  NM_001044762.1  NP_001038227.1 


    ENSEMBL Gene Tree for CGN (if available)
    TreeFam Gene Tree for CGN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CGN gene
    CGNL12  
    4 SIMAP similar genes for CGN using alignment to 5 protein entries:     CING_HUMAN (see all proteins):
    MYH7B    MYH10    MYH11    CGNL1

    Find genes that share paralogs with CGN           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CGN (see all 700)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1125937481,2
    C,F--151481943(+) AGCCCG/AGTGTG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1872567771,2
    --151482233(+) GTGAAA/GCCCTG 1 -- us2k10--------
    rs1904443261,2
    --151482254(+) AAAATA/CCAAAA 1 -- us2k10--------
    rs1149403051,2
    F--151482309(+) GAGCCG/CAGATT 1 -- us2k11Minor allele frequency- C:0.07NA 120
    rs1816306691,2
    --151482338(+) CTGGGC/TGATAG 1 -- us2k10--------
    rs1867655001,2
    --151482366(+) AAAAAA/CAAAAA 1 -- us2k10--------
    rs18915941,2
    C,F,H--151482369(-) ttgttG/Tttttt 1 -- us2k1 trp315Minor allele frequency- T:0.06NS EA NA WA CSA 669
    rs107888081,2
    C,F,A,H--151482459(+) AAAAAC/TAAGAA 1 -- us2k111Minor allele frequency- T:0.49NA WA CSA EA 374
    rs75475901,2
    C,F--151482468(+) aaaaaT/Attttt 1 -- us2k11Minor allele frequency- A:0.50EA 120
    rs760095411,2
    F--151482474(+) TTTTTT/AAAAAA 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for CGN (151482986 - 151511168 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CGN: --
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CGN
    DNA2.0 Custom Variant and Variant Library Synthesis for CGN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 609473    OMIM disorders: --


    Find genes that share disorders with CGN           About GenesLikeMe

    4 Novoseek inferred disease relationships for CGN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma 9.21 2 2012170 (2)
    metastasis 0.241 2 2012170 (1)
    carcinoma squamous cell 0 4 17585317 (2)
    tumors 0 7 2012170 (1), 17585317 (1)

    Genetic Association Database (GAD): CGN

    Export disorders for CGN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CGN gene, integrated from 10 sources (see all 70):
    (articles sorted by number of sources associating them with CGN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and Xenopus cingulin share a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assembly. (PubMed id 11042084)1, 2, 3, 9 Citi S.... Parry D.A.D. (J. Struct. Biol. 2000)
    2. Evidence for a functional interaction between cingulin and ZO-1 in cultured cells. (PubMed id 12023291)1, 2, 9 D'Atri F.... Citi S. (J. Biol. Chem. 2002)
    3. Tight junctions of the blood-brain barrier: development, composition and regulation. (PubMed id 12529927)1, 3, 9 Wolburg H. and Lippoldt A. (Vascul. Pharmacol. 2002)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)
    7. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (DNA Res. 2000)
    8. Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition. (PubMed id 15866167)1, 9 Aijaz S....Matter K. (Dev. Cell 2005)
    9. Protein interaction network of the mammalian Hippo pathway reveals mechanisms of kinase-phosphatase interactions. (PubMed id 24255178)1 Couzens A.L....Gingras A.C. (Sci Signal 2013)
    10. Proteomics strategy to identify substrates of LNX, a PDZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (J. Proteome Res. 2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 57530 HGNC: 17429 AceView: CGN Ensembl:ENSG00000143375 euGenes: HUgn57530
    ECgene: CGN Kegg: 57530 H-InvDB: CGN

    (According to HUGE)
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    HUGE: KIAA1319

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CGN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CGN gene:
    Search GeneIP for patents involving CGN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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