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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CGN Gene

protein-coding   GIFtS: 56
GCID: GC01P151483

cingulin
 Explore 7 diseases affiliated with
CGN via
MalaCards
our new
 Human Malady Compendium 
Biological research products
for CGN    

Aliases
for CGN gene

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, and/or 10fRNAdb)
About This Section
Aliases
Cingulin1
KIAA13191 3

External Ids:    HGNC: 174291   Entrez Gene: 575302   Ensembl: ENSG000001433757   OMIM: 6094735   UniProtKB: Q9P2M73   

Export aliases for CGN gene to outside databases

Previous GC identifers: GC01P149325 GC01P147231 GC01P148258 GC01P148700 GC01P148296 GC01P149750 GC01P122861


Summaries
for CGN gene

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section
UniProtKB/Swiss-Prot: CING_HUMAN, Q9P2M7
Function: Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability
barrier

Gene Wiki entry for CGN (Cingulin)


Genomic Views
for CGN gene

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.1  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CGN gene promoter:
         IRF-1   HNF-4alpha2   HNF-4alpha1   CREB   E2F   E2F-1   deltaCREB   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CGN promoter sequence
   Search SABiosciences Chromatin IP Primers for CGN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CGN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

CGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CGN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P151483:  view genomic region     (about GC identifiers)

Start:
 151,482,986 bp from pter      End:
 151,511,168 bp from pter
Size:
 28,183 bases      Orientation:
 plus strand

Proteins
for CGN gene

(According to 1UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to 2PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section
UniProtKB/Swiss-Prot: CING_HUMAN, Q9P2M7 (See protein sequence)
Recommended Name: Cingulin  
Size: 1197 amino acids; 136386 Da
Subunit: Homodimer (By similarity). Interacts with TJP1/ZO-1
Subcellular location: Cell junction, tight junction (By similarity). Note=Localizes to the apical junction complex
composed of tight and adherens junctions (By similarity)
Sequence caution: Sequence=AAF74498.1; Type=Erroneous initiation; Sequence=AAI52446.1; Type=Erroneous initiation;
Sequence=BAA92557.1; Type=Erroneous initiation; Sequence=BAF82696.1; Type=Erroneous initiation; Sequence=CAI16590.1;
Type=Erroneous initiation; Sequence=EAW53434.1; Type=Erroneous initiation;
Secondary accessions: A6H8L3 A7MD22 Q5T386 Q9NR25
Alternative splicing: 2 isoforms:  Q9P2M7-1   Q9P2M7-2   (May be due to an intron retention)

Explore the universe of human proteins at neXtProt for CGN: NX_Q9P2M7

Post-translational modifications:

  • View modification sites using PhosphoSitePlus2
  • View neXtProt modification sites for NX_Q9P2M7

    • CGN Protein expression data from MOPED and PaxDb:    About this image 
    Estimated protein expression log10 (pmol).

    REFSEQ proteins: NP_065821.1  
    ENSEMBL proteins: 
     ENSP00000425532   ENSP00000422299   ENSP00000410836   ENSP00000271636   ENSP00000390686  
    Reactome Protein details: Q9P2M7
    Human Recombinant Protein Products: 
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom Protein Services for CGN 
    GenScript Custom Purified and Recombinant Proteins Services for CGN
    Browse Sino Biological Recombinant Proteins
    Browse ProSpec Recombinant Proteins
    Uscn Proteins for CGN

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005923tight junction NAS12529927
    GO:0016459myosin complex IEA--
    GO:0030054cell junction TAS--
    GO:0043296apical junction complex ----


    CGN for ontologies           About GeneDecksing



    CGN Antibody Products: 
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    Novus Biologicals CGN Antibodies
    Search for Antibodies for CGN at Abcam  
    Uscn Antibodies for CGN
    Search ThermoFisher Antibodies for CGN

    Assay Products for CGN: 
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    Uscn ELISAs and CLIAs for CGN

    Protein Domains /
    Families
    for CGN gene

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    CGN for domains           About GeneDecksing

    1 InterPro domain/family:
     IPR002928 Myosin_tail

    Graphical View of Domain Structure for InterPro Entry Q9P2M7

    ProtoNet protein and cluster: Q9P2M7

    UniProtKB/Swiss-Prot: CING_HUMAN, Q9P2M7
    Domain: Deletion of the ZO-1 interaction motif (ZIM) decreases but does not abolish colocalization with ZO-1
    Similarity: Belongs to the cingulin family


    Function
    for CGN gene

    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
    About This Section
    Function Summary:

         UniProtKB/Swiss-Prot: CING_HUMAN, Q9P2M7
    Function: Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular permeability
    barrier

    miRNA
    Products:            		miRTarBase miRNAs that target CGN:
    hsa-mir-125b (MIRT004994)

    OriGene 3'-UTR Clone: CGN
    Browse MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CGN
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate CGN (see all 19):
    hsa-miR-3910 hsa-miR-125a-5p hsa-miR-202 hsa-miR-486-3p hsa-miR-3133 hsa-miR-124 hsa-miR-125b hsa-miR-15b*
    SwitchGear 3'UTR luciferase reporter plasmid: CGN 3' UTR sequence
    Inhib. RNA
    Products:            		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CGN (see all 4)
    OriGene shRNA RFP: CGN
    OriGene siRNA: CGN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CGN

    Gene Editing
    Products:    		DNA2.0 Custom Protein Engineering Service for CGN

    Clone
    Products:             		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CGN (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CGN
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CGN (NM_006998)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CGN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CGN 

    Cell Line
    Products:             		GenScript Custom overexpressing Cell Line Services for CGN
    Search LifeMap BioReagents cell lines for CGN

    In Situ Assay
    Products:       
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGN

    Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0003779actin binding ISS--
    GO:0005515protein binding IPI11042084


    CGN for ontologies           About GeneDecksing


    2 GenomeRNAi human phenotypes for CGN:
     Decreased viability of wild-ty  Increased G1 DNA content 


    Pathways & Interactions
    for CGN gene

    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
    About This Section

    Unified GeneCards pathways - 5/8 super-pathways (see all 8) About this table 
    See pathways by source

    Super-pathwaycontained gene-specific pathways
    1Cell adhesion_Gap junctions
    		Cell adhesion_Gap junctions1.00
    		Cell adhesion Gap junctions0.89
    2Cell adhesion Tight junctions
    		Cell adhesion Tight junctions1.00
    		Cell adhesion_Tight junctions0.99
    3Cell adhesion Endothelial cell contacts by junctional mechanisms
    		Cell adhesion Endothelial cell contacts by junctional mechanisms1.00
    		Cell adhesion_Endothelial cell contacts by junctional mechanisms0.97
    4Sertoli-Sertoli Cell Junction Dynamics
    		Sertoli-Sertoli Cell Junction Dynamics1.00
    		Epithelial Tight Junctions0.36
    5TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)
    		TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)1.00
    		Disassembly of tight junctions0.94

    Pathway sources
    See GeneCards unified pathways
    Show all pathways

    3 EMD Millipore Pathways for CGN
        Cell adhesion Gap junctions
    Cell adhesion Tight junctions
    Cell adhesion Endothelial cell contacts by junctional mechanisms

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CGN
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions

    3 GeneGo (Thomson Reuters) Pathways for CGN
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Tight junctions
    Cell adhesion Gap junctions

    4        Reactome Pathways for CGN
        Signaling by TGF-beta Receptor Complex
    Signal Transduction
    Disassembly of tight junctions
    TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)


    1         Kegg Pathway  (Kegg details for CGN):
        Tight junction


    CGN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CGN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for CGN (Q9P2M72, 3 ENSP000002716364) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50356 I2D: score=4 STRING: ENSP00000306330
    SFNP319472, 3MINT-3974952 I2D: score=2 
    YWHAZP631042, 3, ENSP000003095034MINT-3318838 I2D: score=1 STRING: ENSP00000309503
    TJP1Q071573, ENSP000002815374I2D: score=4 STRING: ENSP00000281537
    ARHGEF2Q929743, ENSP000003153254I2D: score=2 STRING: ENSP00000315325
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0008150biological_process ND--


    CGN for ontologies           About GeneDecksing



    Drugs & Compounds
    for CGN gene

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CGN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CGN
    4 Novoseek chemical compound relationships for CGN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    biotin 30.6 1 10940624 (1)
    calcium 22.2 8 7593331 (3), 1556151 (1), 19176351 (1)
    cycloheximide 20.2 1 15634758 (1)
    serine 10.5 1 7593331 (1)

    Search CenterWatch for drugs/clinical trials and news about CGN / CING 

    Transcripts
    for CGN gene

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section
    REFSEQ mRNAs for CGN gene: 
    NM_020770.2  

    Unigene Cluster for CGN:

    Cingulin
    Hs.591464  [show with all ESTs]
    Unigene Representative Sequence: BC146657
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505188 ENST00000502442 ENST00000427934 ENST00000271636(uc009wmw.3)
    ENST00000416743 ENST00000464886 ENST00000473377(uc010pde.2) ENST00000467998


    miRNA
    Products:             		 OriGene 3'-UTR Clone: CGN
    Browse OriGene MicroRNA Expression Plasmids
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CGN
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate CGN (see all 19):
    hsa-miR-3910 hsa-miR-125a-5p hsa-miR-202 hsa-miR-486-3p hsa-miR-3133 hsa-miR-124 hsa-miR-125b hsa-miR-15b*
    SwitchGear 3'UTR luciferase reporter plasmid: CGN 3' UTR sequence
    Inhib. RNA
    Products:             		Browse for Gene Knock-down Tools from EMD Millipore
    OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CGN (see all 4)
    OriGene shRNA RFP: CGN
    OriGene siRNA: CGN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CGN
    Clone
    Products:             		 OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CGN (see all 2)
    OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CGN
    OriGene custom cloning services – gene synthesis, subcloning, mutagenesis, variant library, vector shuttling 
    GenScript: all cDNA clones in your preferred vector: CGN (NM_006998)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CGN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CGN 
    Primer
    Products:            		 OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CGN
    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CGN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CGN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CGN

    Additional cDNA sequence: 

    AB037740.1 AF263462.1 AK290007.1 BC146657.1 BC150604.1 BC152445.1 BX647343.1 DQ656045.2 
    DQ656046.2 

    6 DOTS entries:

    DT.441586  DT.101975686  DT.100818183  DT.121448827  DT.121448820  DT.40125203 

    24/144 AceView cDNA sequences (see all 144):

    AI420955 AA516438 AI015351 BM714478 AI354620 BM352700 CK821947 AA293711 
    BU739454 CB241818 BE467550 BE218913 AI669161 AI698733 CB156995 AA872166 
    CK821946 AB037740 BU785515 AI280931 AA480171 AA342213 BM069563 AA325786 

    GeneLoc Exon Structure


    Expression
    for CGN gene

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CGN expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS
    CGAP TAG: TGCCCAACTT

    Microarray
    RNAseq (Illumina Body Map)
    (100×FPKM)½
    SAGE (Serial Analysis of Gene Expression)
    About this image

    CGN expression in embryonic tissues and stem cells
    Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine    About this table
    1 LifeMap In Vivo Development Anatomical Compartment/Cell 
    Tissue Anatomical Compartment CellCategory (developmental path)
    HeartAtrioventricular CanalAtrioventricular Canal CellsMyocardium
    Expression: Positive    Negative     Selective marker
    Experimental details: Curated     Microarrays     In-situ hybridization
    Stem Cell Differentiation: 2 LifeMap Cells 
    NameCategory
    PureStem™ epithelial progenitor E164 (Embryonic Progenitor Cell)Intermediate Mesoderm, Kidney
    Definitive endoderm-like cells (Generation of mesend...)

    See CGN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CGN

    SOURCE GeneReport for Unigene cluster: Hs.591464

    UniProtKB/Swiss-Prot: CING_HUMAN, Q9P2M7
    Tissue specificity: Localized on the cytoplasmic face of tight junctions of polarized epithelia and some endothelia.
    Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart

        SABiosciences Expression via Pathway-Focused PCR Array including CGN: 
              Tight Junctions in human mouse rat

    Primer
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    Browse OriGene validated miRNA SYBR primer pairs
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CGN
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CGN
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CGN
    In Situ
    Assay Products:     
         		Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGN

    Orthologs
    for CGN gene

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section
    This gene was present in the common ancestor of animals.

    Orthologs for CGN gene from 6/17 species (see all 17)    About this table
    Organism Taxonomic
    classification    		 Gene Description Human
    Similarity    		 Orthology
    Type    		 Details
    chicken
    (Gallus gallus)    		 Aves CGN1 cingulin 63.27(n)
    56.56(a)    		   425665  XM_423398.3  XP_423398.3 
    lizard
    (Anolis carolinensis)    		 Reptilia CGN6
    --
    		 --
    		 49(a)
    23(a)
    		 1 ↔ 1
    possible ortholog
    		 GL343554.1(195798-245464)
    GL343680.1(160971-163659)
    African clawed frog
    (Xenopus laevis)    		 Amphibia AF207901.12   -- 77.3(n)    AF207901.1 
    zebrafish
    (Danio rerio)    		 Actinopterygii LOC5614231 cingulin-like 49.8(n)
    40.96(a)    		   561423  XM_684828.4  XP_689920.3 
    fruit fly
    (Drosophila melanogaster)    		 Insecta Prm6
    		 Paramyosin
    		 16(a)
    		 possible ortholog
    		 3L(8725958-8738410)
    worm
    (Caenorhabditis elegans)    		 Secernentea unc-156
    		 Paramyosin
    		 16(a)
    		 possible ortholog
    		 I(7376601-7383194)


    ENSEMBL Gene Tree for CGN (if available)
    TreeFam Gene Tree for CGN (if available) 

    Paralogs
    for CGN gene

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CGN gene
    CCDC102A2  CGNL12  CCDC102B2  
    4 SIMAP similar genes for CGN using alignment to 5 protein entries:     CING_HUMAN (see all proteins):
    MYH7B    MYH10    MYH11    CGNL1

    CGN for paralogs           About GeneDecksing



    Genomic Variants
    for CGN gene

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/527 NCBI SNPs in CGN are shown (see all 527)     About this table
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance    		Chr 1 posSequence#AA
    Chg    		TypeMore#Allele
    freq    		PopTotal
    sample    		More
    ----------
    rs1125937481,2
    		--151481943(+) AGCCCG/AGTGTG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1872567771,2
    		--151482233(+) GTGAAA/GCCCTG 1 -- us2k10--------
    rs1904443261,2
    		--151482254(+) AAAATA/CCAAAA 1 -- us2k10--------
    rs1149403051,2
    		F,--151482309(+) GAGCCG/CAGATT 1 -- us2k11Minor allele frequency- C:0.07NA 120
    rs1816306691,2
    		--151482338(+) CTGGGC/TGATAG 1 -- us2k10--------
    rs1867655001,2
    		--151482366(+) AAAAAA/CAAAAA 1 -- us2k10--------
    rs18915941,2
    		C,F,H,--151482369(-) TTGTTA/C/G/T 
                TTTTT     		1 -- us2k1 trp315NS EA NA WA CSA 669
    rs107888081,2
    		C,F,A,H,--151482459(+) AAAAAC/TAAGAA 1 -- us2k111Minor allele frequency- T:0.49NA WA CSA EA 374
    rs75475901,2
    		C,F,--151482468(+) AAAAAT/ATTTTT 1 -- us2k11Minor allele frequency- A:0.50EA 120
    rs760095411,2
    		F,--151482474(+) TTTTTT/AAAAAA 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for CGN (151482986 - 151511168 bp)
    Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
          Database of Genomic Variants (DGV) variations for CGN: --

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    Disorders / Diseases
    for CGN gene

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    CGN for disorders           About GeneDecksing

    OMIM gene information: 609473    OMIM disorders: --

    7 diseases for CGN:    About MalaCards
    squamous cell carcinoma    lung squamous cell carcinoma    cystitis    adenocarcinoma
    carcinoma    breast cancer    interstitial cystitis

    4 Novoseek disease relationships for CGN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma 9.21 2 2012170 (2)
    metastasis 0.241 2 2012170 (1)
    carcinoma squamous cell 0 4 17585317 (2)
    tumors 0 7 2012170 (1), 17585317 (1)


    Export disorders for CGN gene to outside databases

    Publications
    for CGN gene

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CGN gene, integrated from 9 sources (see all 67):
    (articles sorted by number of sources associating them with CGN)    		    Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and Xenopus cingulin share a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assembly. (PubMed id 11042084)1, 2, 3, 9 Citi S.... Parry D.A.D. (2000)
    2. Evidence for a functional interaction between cingulin and ZO-1 in cultured cells. (PubMed id 12023291)1, 2, 9 D'Atri F.... Citi S. (2002)
    3. Tight junctions of the blood-brain barrier: developme nt, composition and regulation. (PubMed id 12529927)1, 3, 9 Wolburg H. and Lippoldt A. (2002)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    7. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    8. Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition. (PubMed id 15866167)1, 9 Aijaz S....Matter K. (2005)
    9. Proteomics strategy to identify substrates of LNX, a P DZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (2012)
    10. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)

    External Searches for CGN gene

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  
      Query String
    		PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    Genome Databases showing CGN gene

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57530 HGNC: 17429 AceView: CGN Ensembl:ENSG00000143375 euGenes: HUgn57530
    ECgene: CGN Kegg: 57530 H-InvDB: CGN

    Other Databases showing CGN gene

    (According to HUGE)
    About This Section
    HUGE: KIAA1319

    Specialized Databases showing CGN gene

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CGN Pharmacogenomics, SNPs, Pathways

    Intellectual Property
    for CGN gene

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    		Patent Information for CGN gene:
    Search GeneIP for patents involving CGN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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