Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 
or upload a file of gene symbols


Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CGN Gene

protein-coding   GIFtS: 60
GCID: GC01P151483

Cingulin

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
cingulin1 2
KIAA13193

External Ids:    HGNC: 174291   Entrez Gene: 575302   Ensembl: ENSG000001433757   OMIM: 6094735   UniProtKB: Q9P2M73   

Export aliases for CGN gene to outside databases

Previous GC identifers: GC01P149325 GC01P147231 GC01P148258 GC01P148700 GC01P148296 GC01P149750 GC01P122861


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

GeneCards Summary for CGN Gene: 
CGN (cingulin) is a protein-coding gene. Diseases associated with CGN include lung squamous cell carcinoma, and cystitis, and among its related super-pathways are Sertoli-Sertoli Cell Junction Dynamics and Cell adhesion Endothelial cell contacts by junctional mechanisms. GO annotations related to this gene include motor activity and actin binding. An important paralog of this gene is CGNL1.

UniProtKB/Swiss-Prot: CING_HUMAN, Q9P2M7
Function: Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular
permeability barrier

Gene Wiki entry for CGN (Cingulin) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NT_004487.19  NC_018912.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CGN gene promoter:
         IRF-1   HNF-4alpha2   HNF-4alpha1   CREB   E2F   E2F-1   deltaCREB   c-Myb   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCGN promoter sequence
   Search SABiosciences Chromatin IP Primers for CGN

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CGN


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q21   Ensembl cytogenetic band:  1q21.3   HGNC cytogenetic band: 1q21

CGN Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CGN gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P151483:  view genomic region     (about GC identifiers)

Start:
151,482,986 bp from pter      End:
151,511,168 bp from pter
Size:
28,183 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CING_HUMAN, Q9P2M7 (See protein sequence)
Recommended Name: Cingulin  
Size: 1197 amino acids; 136386 Da
Subunit: Homodimer (By similarity). Interacts with TJP1/ZO-1
Subcellular location: Cell junction, tight junction (By similarity). Note=Localizes to the apical junction complex
composed of tight and adherens junctions (By similarity)
Sequence caution: Sequence=AAF74498.1; Type=Erroneous initiation; Sequence=AAI52446.1; Type=Erroneous initiation;
Sequence=BAA92557.1; Type=Erroneous initiation; Sequence=BAF82696.1; Type=Erroneous initiation;
Sequence=CAI16590.1; Type=Erroneous initiation; Sequence=EAW53434.1; Type=Erroneous initiation;
Secondary accessions: A6H8L3 A7MD22 Q5T386 Q9NR25
Alternative splicing: 2 isoforms:  Q9P2M7-1   Q9P2M7-2   (May be due to an intron retention)

Explore the universe of human proteins at neXtProt for CGN: NX_Q9P2M7

Explore proteomics data for CGN at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9P2M7

  • CGN Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CGN Protein Expression
    REFSEQ proteins: NP_065821.1  
    ENSEMBL proteins: 
     ENSP00000425532   ENSP00000422299   ENSP00000410836   ENSP00000271636   ENSP00000390686  
    Reactome Protein details: Q9P2M7
    Human Recombinant Protein Products for CGN: 
    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    Browse OriGene Protein Over-expression Lysates
    OriGene Custom MassSpec 
    OriGene Custom Protein Services for CGN
    GenScript Custom Purified and Recombinant Proteins Services for CGN
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CGN 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005923tight junction NAS12529927
    GO:0016459myosin complex IEA--
    GO:0030054cell junction TAS--
    GO:0043296apical junction complex ----

    CGN for ontologies           About GeneDecksing



    CGN Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CGN
    GenScript Custom Superior Antibodies Services for CGN
    Novus Biologicals CGN Antibodies
    Abcam antibodies for CGN
    Cloud-Clone Corp. Antibodies for CGN 
    ThermoFisher Antibodies for CGN
    LSBio Antibodies in human, mouse, rat for CGN 

    Assay Products for CGN: 
    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CGN
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CGN
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CGN 
    Cloud-Clone Corp. CLIAs for CGN


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    1 InterPro protein domain:
     IPR002928 Myosin_tail

    Graphical View of Domain Structure for InterPro Entry Q9P2M7

    ProtoNet protein and cluster: Q9P2M7

    UniProtKB/Swiss-Prot: CING_HUMAN, Q9P2M7
    Domain: Deletion of the ZO-1 interaction motif (ZIM) decreases but does not abolish colocalization with ZO-1
    Similarity: Belongs to the cingulin family


    CGN for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CING_HUMAN, Q9P2M7
    Function: Probably plays a role in the formation and regulation of the tight junction (TJ) paracellular
    permeability barrier

         Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003774motor activity IEA--
    GO:0003779actin binding ISS--
    GO:0005515protein binding IPI11042084
         
    CGN for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CGN:
     Decreased viability of wild-ty  Increased G1 DNA content 

         2 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cgn):
     digestive/alimentary  homeostasis/metabolism 

    CGN for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Cgntm1.1Citi for CGN

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CGN 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CGN

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CGN 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CGN 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CGN:
    hsa-mir-125b (MIRT004994)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CGN
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate CGN (see all 19):
    hsa-miR-3910 hsa-miR-125a-5p hsa-miR-202 hsa-miR-486-3p hsa-miR-3133 hsa-miR-124 hsa-miR-125b hsa-miR-15b*
    SwitchGear 3'UTR luciferase reporter plasmidCGN 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CGN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CGN

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CGN
    Sirion Biotech Customized adenovirus for overexpression of CGN

    Clone
    Products:
         
    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CGN (see all 5)
    OriGene ORF clones in mouse, rat for CGN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CGN (NM_006998)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CGN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CGN
    Sirion Biotech Customized lentivirus for stable overexpression of CGN 
                         Customized lentivirus expression plasmids for stable overexpression of CGN 

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CGN
    Search LifeMap BioReagents cell lines for CGN
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGN


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CGN About   (see all 8)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Sertoli-Sertoli Cell Junction Dynamics
    Sertoli-Sertoli Cell Junction Dynamics0.38
    Epithelial Tight Junctions0.36
    2Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Endothelial cell contacts by junctional mechanisms0.97
    3Cell adhesion Gap junctions
    Cell adhesion Gap junctions0.89
    4Transcriptional activity of SMAD2/SMAD3:SMAD4 heterotrimer
    Signaling by TGF-beta Receptor Complex0.61
    5Signaling by GPCR
    Signal Transduction0.55

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    3 EMD Millipore Pathways for CGN
        Cell adhesion Gap junctions
    Cell adhesion Tight junctions
    Cell adhesion Endothelial cell contacts by junctional mechanisms

    2 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CGN
        Sertoli-Sertoli Cell Junction Dynamics
    Epithelial Tight Junctions

    3 GeneGo (Thomson Reuters) Pathways for CGN
        Cell adhesion Endothelial cell contacts by junctional mechanisms
    Cell adhesion Tight junctions
    Cell adhesion Gap junctions

    3        Reactome Pathways for CGN
        Signaling by TGF-beta Receptor Complex
    Signal Transduction
    TGF-beta receptor signaling in EMT (epithelial to mesenchymal transition)


    1         Kegg Pathway  (Kegg details for CGN):
        Tight junction


    CGN for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CGN

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/48 Interacting proteins for CGN (Q9P2M72, 3 ENSP000002716364) via UniProtKB, MINT, STRING, and/or I2D (see all 48)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    YWHAGP619812, 3, ENSP000003063304MINT-50356 I2D: score=4 STRING: ENSP00000306330
    SFNP319472, 3MINT-3974952 I2D: score=2 
    YWHAZP631042, 3, ENSP000003095034MINT-3318838 I2D: score=1 STRING: ENSP00000309503
    TJP1Q071573, ENSP000002815374I2D: score=4 STRING: ENSP00000281537
    ARHGEF2Q929743, ENSP000003153254I2D: score=2 STRING: ENSP00000315325
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007179transforming growth factor beta receptor signaling pathway TAS--
    GO:0008150biological_process ND--

    CGN for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CGN for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CGN (CING)

    4 Novoseek inferred chemical compound relationships for CGN gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    biotin 30.6 1 10940624 (1)
    calcium 22.2 8 7593331 (3), 1556151 (1), 19176351 (1)
    cycloheximide 20.2 1 15634758 (1)
    serine 10.5 1 7593331 (1)

    Search CenterWatch for drugs/clinical trials and news about CGN / CING

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CGN gene: 
    NM_020770.2  

    Unigene Cluster for CGN:

    Cingulin
    Hs.591464  [show with all ESTs]
    Unigene Representative Sequence: BC146657
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000505188 ENST00000502442 ENST00000427934 ENST00000271636(uc009wmw.3)
    ENST00000416743 ENST00000464886 ENST00000473377(uc010pde.2) ENST00000467998

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CGN
    8/19 QIAGEN miScript miRNA Assays for microRNAs that regulate CGN (see all 19):
    hsa-miR-3910 hsa-miR-125a-5p hsa-miR-202 hsa-miR-486-3p hsa-miR-3133 hsa-miR-124 hsa-miR-125b hsa-miR-15b*
    SwitchGear 3'UTR luciferase reporter plasmidCGN 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CGN
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CGN
    Clone
    Products:
         
    OriGene clones in human, mouse for CGN (see all 5)
    OriGene ORF clones in mouse, rat for CGN
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CGN (NM_006998)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CGN
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CGN
    Sirion Biotech Customized lentivirus for stable overexpression of CGN 
                         Customized lentivirus expression plasmids for stable overexpression of CGN 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CGN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CGN
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CGN
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CGN

    Additional mRNA sequence: 

    AB037740.1 AF263462.1 AK290007.1 BC146657.1 BC150604.1 BC152445.1 BX647343.1 DQ656045.2 
    DQ656046.2 

    6 DOTS entries:

    DT.441586  DT.101975686  DT.100818183  DT.121448827  DT.121448820  DT.40125203 

    24/144 AceView cDNA sequences (see all 144):

    BE467550 AI354620 AI669161 BM714478 BE219551 AI698733 AW445027 AA342213 
    AA325786 AA293711 BU739454 AI015351 AB037740 AA872166 AA394274 BM352700 
    BE218606 AA516438 BX095062 AI620406 CK821946 AI302109 AA960974 AA342212 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CGN expression in normal human tissues (normalized intensities)      CGN embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGCCCAACTT
    CGN Expression
    About this image


    CGN expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/21 selected tissues (see all 21) fully expand
     
     Inner Cell Mass (Early Embryonic Tissues)    fully expand to see all 6 entries
             ESI-049   
     
     Epithelium (Uncategorized)    fully expand to see all 5 entries
             Human Pulmonary Alveolar Epithelial Cells (HPAEpiC)   
     
     Uterus (Reproductive System)    fully expand to see all 3 entries
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 3 entries
             seminal vesicle ; glandular cells   
     
     Lung (Respiratory System)    fully expand to see all 3 entries
             lung ; pneumocytes   

    See CGN Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CGN

    SOURCE GeneReport for Unigene cluster: Hs.591464

    UniProtKB/Swiss-Prot: CING_HUMAN, Q9P2M7
    Tissue specificity: Localized on the cytoplasmic face of tight junctions of polarized epithelia and some
    endothelia. Expressed in pancreas, kidney, liver and lung, but not in skeletal muscle, placenta, brain or heart

        SABiosciences Expression via Pathway-Focused PCR Array including CGN: 
              Tight Junctions in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CGN
    SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CGN
    QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CGN
    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CGN
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGN

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CGN gene from 6/13 species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cgn1 , 5 cingulin1, 5 85.7(n)1
    87.07(a)1
      3 (40.74 cM)5
    707371  NM_001037711.21  NP_001032800.21 
     947600695 
    chicken
    (Gallus gallus)
    Aves CGN1 cingulin 63.27(n)
    56.56(a)
      425665  XM_423398.3  XP_423398.3 
    African clawed frog
    (Xenopus laevis)
    Amphibia AF207901.12   -- 77.3(n)    AF207901.1 
    zebrafish
    (Danio rerio)
    Actinopterygii LOC5614231 cingulin-like 49.8(n)
    40.96(a)
      561423  XM_684828.4  XP_689920.3 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG316386
    --
    11(a)
    1 → many
    2L(6491122-6496986)
    worm
    (Caenorhabditis elegans)
    Secernentea F53F10.16
    Protein F53F10.1
    13(a)
    1 → many
    I(3834117-3837765)


    ENSEMBL Gene Tree for CGN (if available)
    TreeFam Gene Tree for CGN (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CGN gene
    CGNL12  
    4 SIMAP similar genes for CGN using alignment to 5 protein entries:     CING_HUMAN (see all proteins):
    MYH7B    MYH10    MYH11    CGNL1

    CGN for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/700 SNPs in CGN are shown (see all 700)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1125937481,2
    C,F--151481943(+) AGCCCG/AGTGTG 1 -- us2k11Minor allele frequency- A:0.50CSA 2
    rs1872567771,2
    --151482233(+) GTGAAA/GCCCTG 1 -- us2k10--------
    rs1904443261,2
    --151482254(+) AAAATA/CCAAAA 1 -- us2k10--------
    rs1149403051,2
    F--151482309(+) GAGCCG/CAGATT 1 -- us2k11Minor allele frequency- C:0.07NA 120
    rs1816306691,2
    --151482338(+) CTGGGC/TGATAG 1 -- us2k10--------
    rs1867655001,2
    --151482366(+) AAAAAA/CAAAAA 1 -- us2k10--------
    rs18915941,2
    C,F,H--151482369(-) ttgttG/Tttttt 1 -- us2k1 trp315Minor allele frequency- T:0.06NS EA NA WA CSA 669
    rs107888081,2
    C,F,A,H--151482459(+) AAAAAC/TAAGAA 1 -- us2k111Minor allele frequency- T:0.49NA WA CSA EA 374
    rs75475901,2
    C,F--151482468(+) aaaaaT/Attttt 1 -- us2k11Minor allele frequency- A:0.50EA 120
    rs760095411,2
    F--151482474(+) TTTTTT/AAAAAA 1 -- us2k11Minor allele frequency- A:0.03WA 118

    HapMap Linkage Disequilibrium report for CGN (151482986 - 151511168 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CGN: --
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CGN
    DNA2.0 Custom Variant and Variant Library Synthesis for CGN

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 609473    OMIM disorders: --

    7 diseases for CGN:    About MalaCards
    lung squamous cell carcinoma    cystitis    colon adenocarcinoma    squamous cell carcinoma
    adenocarcinoma    endotheliitis    breast cancer


    CGN for disorders           About GeneDecksing

    4 Novoseek inferred disease relationships for CGN gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    adenocarcinoma 9.21 2 2012170 (2)
    metastasis 0.241 2 2012170 (1)
    carcinoma squamous cell 0 4 17585317 (2)
    tumors 0 7 2012170 (1), 17585317 (1)

    Genetic Association Database (GAD): CGN

    Export disorders for CGN gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CGN gene, integrated from 9 sources (see all 69):
    (articles sorted by number of sources associating them with CGN)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human and Xenopus cingulin share a modular organization of the coiled-coil rod domain: predictions for intra- and intermolecular assembly. (PubMed id 11042084)1, 2, 3, 9 Citi S.... Parry D.A.D. (2000)
    2. Evidence for a functional interaction between cingulin and ZO-1 in cultured cells. (PubMed id 12023291)1, 2, 9 D'Atri F.... Citi S. (2002)
    3. Tight junctions of the blood-brain barrier: developme nt, composition and regulation. (PubMed id 12529927)1, 3, 9 Wolburg H. and Lippoldt A. (2002)
    4. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    6. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (2003)
    7. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PubMed id 10718198)1, 2 Nagase T.... Ohara O. (2000)
    8. Binding of GEF-H1 to the tight junction-associated adaptor cingulin results in inhibition of Rho signaling and G1/S phase transition. (PubMed id 15866167)1, 9 Aijaz S....Matter K. (2005)
    9. Proteomics strategy to identify substrates of LNX, a P DZ domain-containing E3 ubiquitin ligase. (PubMed id 22889411)1 Guo Z....Gao Y. (2012)
    10. Functional dissection of lysine deacetylases reveals t hat HDAC1 and p300 regulate AMPK. (PubMed id 22318606)1 Lin Y.Y....Boeke J.D. (2012)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 57530 HGNC: 17429 AceView: CGN Ensembl:ENSG00000143375 euGenes: HUgn57530
    ECgene: CGN Kegg: 57530 H-InvDB: CGN

    (According to HUGE)
    About This Section
    HUGE: KIAA1319

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CGN Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CGN gene:
    Search GeneIP for patents involving CGN

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

     
     EMD Millipore Custom Antibody & Bulk Services
     EMD Millipore Preclinical / Clinical Development Services
     EMD Millipore Immunoassay Services
     EMD Millipore Target Screening & Profiling Services

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Kinase Activity Assays/Reagents  
     Browse ELISpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Multiplex/Array Assay Kits/Reagents  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Protease Activity Assays and Reagents   Browse Recombinant/Natural Proteins  
     Browse Stem Cell Products   Browse Tocris Biochemicals & Compounds  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CGN  
     Browse OriGene qPCR primer pairs and template standards   Browse OriGene Protein Over-expression Lysates  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CGN  
     OriGene qSTAR qPCR primer pairs in human, mouse for CGN   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     OriGene ORF clones in mouse, rat for CGN   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CGN   OriGene Custom Protein Services for CGN  

     
     
     QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CGN
     QIAGEN SeqTarget long-range PCR primers for resequencing CGN
     QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CGN
     QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CGN
     QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CGN
     QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CGN
     GenScript Custom Purified and Recombinant Proteins Services for CGN GenScript cDNA clones with any tag delivered in your preferred vector for CGN
     GenScript Custom Assay Services for CGN GenScript Custom Superior Antibodies Services for CGN
     GenScript Custom overexpressing Cell Line Services for CGN CloneReady with Over 120,000 Genes
     Gene Synthesis: Any Gene in Any Vector Vector-based siRNA and miRNA, Ready for Transfection
     Gene Mutant Library, Variants up to 10^11 Plasmid Preparation
     Custom Peptide Services
     Search for Antibodies & Assays

     Regulatory tfbs in CGN promoter
     Search Chromatin IP Primers for CGN
     RT2 qPCR Primer Assay in human, mouse, rat CGN
     GNC Network for CGN
     SABiosciences PCR Arrays including human, mouse, rat CGN
     Search Tocris compounds for CGN (CING)
     Browse Sino Biological Proteins and Antibodies
     Browse Sino Biological Cell Lysates
     Browse Sino Biological cDNA Clones
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies
     Novus Tissue Slides
     CGN antibodies
     Antibodies for CGN
     See all of Abcam's Antibodies, Kits and Proteins for CGN
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins




     Proteins for CGN
     Antibodies for CGN
     ELISAs for CGN
     CLIAs for CGN
     Search LifeMap BioReagents cell lines for CGN
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGN
     SwitchGear 3'UTR luciferase reporter plasmids for CGN
     SwitchGear Promoter luciferase reporter plasmids for CGN
     ThermoFisher Antibodies for CGN
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CGN
     inGenious Targeting Laboratory - Custom generated mouse model solutions for CGN
     inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CGN
    Customized:
     lentivirus for stable overexpression of CGN
     lentivirus expression plasmids for stable overexpression of CGN
     adenovirus for overexpression of CGN
     LSBio Antibodies in human, mouse, rat for CGN
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
           
    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

    View Random Gene

    Category
    (GIFtS: 73)
    transforming growth factor, beta 1
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CGN gene at Home site.
    hostname: 356977-web1.xennexinc.com index build: 106 solr: 1.4