Aliases for CGB8 Gene
External Ids for CGB8 Gene
Previous GeneCards Identifiers for CGB8 Gene
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 8 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]
GeneCards Summary for CGB8 Gene
CGB8 (Chorionic Gonadotropin Beta Subunit 8) is a Protein Coding gene. Diseases associated with CGB8 include Ulcerative Stomatitis and Mixed Ductal-Endocrine Carcinoma. Among its related pathways are Transcriptional regulation by the AP-2 (TFAP2) family of transcription factors and Peptide hormone metabolism. GO annotations related to this gene include hormone activity. An important paralog of this gene is CGB5.
UniProtKB/Swiss-Prot for CGB8 Gene
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.