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Aliases for CGB8 Gene

Aliases for CGB8 Gene

  • Chorionic Gonadotropin, Beta Polypeptide 8 2 3
  • Chorionic Gonadotrophin Chain Beta 4
  • CGB CGB5 CGB7 CGB8 4
  • CG-Beta 4
  • CGB3 4

External Ids for CGB8 Gene

Previous GeneCards Identifiers for CGB8 Gene

  • GC19M050210
  • GC19M049919
  • GC19M054226
  • GC19M054243
  • GC19M054245
  • GC19M054247
  • GC19M054227
  • GC19M054228
  • GC19M054229
  • GC19M054248
  • GC19M049550
  • GC19M045927

Summaries for CGB8 Gene

Entrez Gene Summary for CGB8 Gene

  • This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 8 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CGB8 Gene

CGB8 (Chorionic Gonadotropin, Beta Polypeptide 8) is a Protein Coding gene. Diseases associated with CGB8 include cryptococcosis. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Peptide hormone metabolism. An important paralog of this gene is TSHB.

UniProtKB/Swiss-Prot for CGB8 Gene

  • Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGB8 Gene

Genomics for CGB8 Gene

Regulatory Elements for CGB8 Gene

Genomic Location for CGB8 Gene

Start:
49,047,638 bp from pter
End:
49,049,111 bp from pter
Size:
1,474 bases
Orientation:
Minus strand

Genomic View for CGB8 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CGB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGB8 Gene

Proteins for CGB8 Gene

  • Protein details for CGB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01233-CGHB_HUMAN
    Recommended name:
    Choriogonadotropin subunit beta
    Protein Accession:
    P01233
    Secondary Accessions:
    • A1A5E0
    • B9ZVP5
    • Q13991
    • Q14000
    • Q3KPI3
    • Q3SY41
    • Q8WTT5
    • Q8WXL1
    • Q8WXL2
    • Q8WXL3
    • Q8WXL4

    Protein attributes for CGB8 Gene

    Size:
    165 amino acids
    Molecular mass:
    17739 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin
    SequenceCaution:
    • Sequence=CAA25068.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA25069.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CGB8 Gene

    Alternative splice isoforms for CGB8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CGB8 Gene

Proteomics data for CGB8 Gene at MOPED

Post-translational modifications for CGB8 Gene

  • Glycosylation at Asn33, Asn50, Ser141, Ser147, Ser152, and Ser158
  • Modification sites at PhosphoSitePlus

Other Protein References for CGB8 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CGB8 Gene

Domains for CGB8 Gene

Suggested Antigen Peptide Sequences for CGB8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P01233

UniProtKB/Swiss-Prot:

CGHB_HUMAN :
  • P01233
Family:
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with CGB8: view

No data available for Gene Families for CGB8 Gene

Function for CGB8 Gene

Molecular function for CGB8 Gene

UniProtKB/Swiss-Prot Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

Gene Ontology (GO) - Molecular Function for CGB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity --
genes like me logo Genes that share ontologies with CGB8: view

Phenotypes for CGB8 Gene

GenomeRNAi human phenotypes for CGB8:
genes like me logo Genes that share phenotypes with CGB8: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CGB8 Gene

Localization for CGB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGB8 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CGB8 Gene COMPARTMENTS Subcellular localization image for CGB8 gene
Compartment Confidence
extracellular 5
cytosol 4
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CGB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
genes like me logo Genes that share ontologies with CGB8: view

Pathways for CGB8 Gene

genes like me logo Genes that share pathways with CGB8: view

Pathways by source for CGB8 Gene

Interacting Proteins for CGB8 Gene

Gene Ontology (GO) - Biological Process for CGB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process --
GO:0007165 signal transduction --
GO:0007267 cell-cell signaling --
GO:0007292 female gamete generation --
GO:0016486 peptide hormone processing --
genes like me logo Genes that share ontologies with CGB8: view

Compounds for CGB8 Gene

UniProtKB/Swiss-Prot:

P01233-CGHB_HUMAN
Pharmaceutical: Available under the names Novarel (Ferring) and Profasi (Serono). Used as adjunctive therapy in the treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting from caloric restriction, that it causes a more attractive or normal distribution of fat, or that it decreases the hunger and discomfort associated with calorie-restricted diets
genes like me logo Genes that share compounds with CGB8: view

Transcripts for CGB8 Gene

mRNA/cDNA for CGB8 Gene

(247) Selected AceView cDNA sequences:
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CGB8 Gene

No ASD Table

Relevant External Links for CGB8 Gene

GeneLoc Exon Structure for
CGB8
ECgene alternative splicing isoforms for
CGB8

Expression for CGB8 Gene

mRNA expression in normal human tissues for CGB8 Gene

mRNA Expression by UniProt/SwissProt for CGB8 Gene

P01233-CGHB_HUMAN
Tissue specificity: Placenta
genes like me logo Genes that share expressions with CGB8: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Protein expression for CGB8 Gene

Orthologs for CGB8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGB8 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia LHB 36
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LHB 36
  • 64 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Lhb 36
  • 62 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia LHB 36
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii lhb 36
  • 39 (a)
OneToMany
Species with no ortholog for CGB8:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGB8 Gene

ENSEMBL:
Gene Tree for CGB8 (if available)
TreeFam:
Gene Tree for CGB8 (if available)

Paralogs for CGB8 Gene

Paralogs for CGB8 Gene

Selected SIMAP similar genes for CGB8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CGB8: view

Variants for CGB8 Gene

Sequence variations from dbSNP and Humsavar for CGB8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs1058676 -- 49,048,776(-) GAGGT(A/T)TAAAG utr-variant-5-prime
rs2161412 -- 49,047,371(-) GGTGG(C/T)GGGCG downstream-variant-500B
rs2387591 -- 49,048,586(+) AGGAA(A/C)TGCCC intron-variant
rs3179073 -- 49,048,761(-) GTACA(A/C)GAGGC utr-variant-5-prime
rs3179074 -- 49,048,748(-) GGGAC(A/G)CACCA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CGB8 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833857 CNV Loss 17160897
nsv912248 CNV Loss 21882294
dgv3970n71 CNV Loss 21882294
nsv833859 CNV Loss 17160897
nsv912251 CNV Loss 21882294
esv22462 CNV Gain 19812545
nsv912252 CNV Loss 21882294
dgv592n67 CNV Loss 20364138

Relevant External Links for CGB8 Gene

HapMap Linkage Disequilibrium report
CGB8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGB8 Gene

Disorders for CGB8 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CGB8 Gene including...

Search for CGB8 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CGB8 Gene

genes like me logo Genes that share disorders with CGB8: view

No data available for UniProtKB/Swiss-Prot for CGB8 Gene

Publications for CGB8 Gene

  1. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PMID: 6194155) Policastro P. … Boime I. (J. Biol. Chem. 1983) 2 3 4
  2. A map of the hCG beta-LH beta gene cluster. (PMID: 2422163) Policastro P.F. … Boime I. (J. Biol. Chem. 1986) 3 4
  3. Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. (PMID: 6690982) Talmadge K. … Fiddes J.C. (Nature 1984) 3 4
  4. Malignant transformation of nontrophoblastic cells is associated with the expression of chorionic gonadotropin beta genes normally transcribed in trophoblastic cells. (PMID: 9012484) Bellet D. … Vidaud M. (Cancer Res. 1997) 3
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CGB8 Gene

Sources for CGB8 Gene

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