CGB8 Gene
protein-coding GIFtS: 44
GCID: GC19M049550
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|
chorionic gonadotropin, beta polypeptide 8
| |
Aliases
for CGB8 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Chorionic Gonadotropin, Beta Polypeptide 81 2 | | Chorionic Gonadotropin Beta 8 Subunit2 | | CG-Beta1 | | CGB33 | | Chorionic Gonadotrophin Chain Beta3 |
Export aliases for CGB8 gene to outside databasesPrevious GC identifers: GC19M050210 GC19M049919 GC19M054226 GC19M054243 GC19M054245 GC19M054247 GC19M054227 GC19M054228 GC19M054229 GC19M054248 GC19M045927 |
Summaries
for CGB8 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CGB8:
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 8 subunit of chorionicgonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique betasubunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulatesthe ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG isencoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with theluteinizing hormone beta subunit gene. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy
|
Genomic Views
for CGB8 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CGB8 gene promoter:
NF-1 NF-1/L Pax-5 p53 POU3F1 Egr-4
Other transcription factors
Search SABiosciences Chromatin IP Primers for CGB8
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CGB8 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.32CGB8 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19M049550: view genomic region
(about GC identifiers)
Start:
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49,550,895 bp from pter |
End:
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49,552,400 bp from pter |
Size:
|
1,506 bases |
Orientation:
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minus strand |
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Proteins
for CGB8 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233 (See
protein sequence)Recommended Name: Choriogonadotropin subunit beta precursor Size: 165 amino acids; 17739 Da
Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity tothyrotropin, lutropin, follitropin and gonadotropin
Subcellular location: Secreted
Developmental stage: Made by the first trimester placenta
Sequence caution: Sequence=CAA25068.1; Type=Erroneous initiation; Sequence=CAA25069.1; Type=Erroneous initiation;
4 PDB 3D structures from  and Proteopedia  for CGB8:1HCN (3D)
1HRP (3D)
1QFW (3D)
1XUL (3D)
Secondary accessions: A1A5E0 B9ZVP5 Q13991 Q14000 Q3KPI3 Q3SY41 Q8WTT5 Q8WXL1 Q8WXL2 Q8WXL3 Q8WXL4Alternative splicing: 2 isoforms: P01233-1 P01233-2 (Ref.2 (CAA25069) sequence is in conflict in positions: 7:G->R, 9:A->V, 12:D->G)Explore the universe of human proteins at neXtProt for CGB8: NX_P01233
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P01233
CGB8 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_149439.1
ENSEMBL proteins: ENSP00000403649 ENSP00000347582 Reactome Protein details: P01233
Human Recombinant Protein Products:
Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
-- | -- | | GO:0005625 | soluble fraction |
-- | -- |
CGB8 for ontologies About GeneDecksing
CGB8 Antibody Products:
Assay Products for CGB8: |
Protein
Domains /
Families
for CGB8 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CGB8 for domains About GeneDecksing
3 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry P01233ProtoNet protein and cluster: P01233 3 Blocks protein families: IPB001545 Gonadotropin IPB002400 Growth factor cystine knot superfamily signature IPB006208 Cystine knot domain
UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233Similarity: Belongs to the glycoprotein hormones subunit beta family |
Function
for CGB8 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CGB8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CGB8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling 
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Synthesis Service for CGB8 | |  | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CGB8 |
Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005179 | hormone activity |
-- | -- |
CGB8 for ontologies About GeneDecksing
1 GenomeRNAi human phenotype for CGB8:
|
Pathways & Interactions
for CGB8 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Pathway sources
See GeneCards unified pathways
Show all pathways
4 
Reactome Pathways for CGB8
CGB8 for pathways About GeneDecksing
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CGB8
STRING Interaction
Network Preview (showing 4 interactants - click image to see more details)
5/8 Interacting proteins for CGB8 (P012332, 3 ENSP000003475824) via UniProtKB, MINT, STRING, and/or I2D (see all 8)About this table
Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table
CGB8 for ontologies About GeneDecksing
|
Drugs & Compounds
for CGB8 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CGB8
UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233Pharmaceutical: Available under the names Novarel (Ferring) and Profasi (Serono). Used as adjunctive therapy in thetreatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting fromcaloric restriction, that it causes a more attractive or 'normal' distribution of fat, or that it decreases the hungerand discomfort associated with calorie-restricted diets
Search CenterWatch for drugs/clinical trials and news about CGB8 / CGHB
|
Transcripts
for CGB8 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CGB8 gene: NM_033183.2 2 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000448456(uc002pmb.4) ENST00000355414
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CGB8
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CGB8
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CGB8 (NM_033183) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CGB8 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CGB8 |
24/247 AceView cDNA sequences (see all 247): NM_033043 NM_033378 BC051378 AA331012 CA944648 BC006290 T50278 AA330859 BC069367 BX336252 CF528169 AI149559 BU752275 BQ011267 N29831 CF528653 AI417614 BX439414 AI128424 BV177010 AA330717 CR597606 BU752320 BU752315
GeneLoc Exon Structure
|
Expression
for CGB8 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CGB8 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --
About this image
See CGB8 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CGB8
UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233Tissue specificity: Placenta
SABiosciences Custom PCR Arrays for CGB8
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CGB8
Browse OriGene validated miRNA SYBR primer pairs
| | | Search SABiosciences RT2 qPCR
Primer Assays in human, mouse, rat CGB8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CGB8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CGB8 |
Orthologs
for CGB8 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of chordates.
Orthologs for CGB8 gene from 2/6 species (see all 6) About this table
| Organism |
Taxonomic
classification |
Gene |
Description |
Human
Similarity |
Orthology
Type |
Details |
lizard
(Anolis carolinensis) |
Reptilia |
-- |
-- |
37(a) |
1 → many |
6(80158039-80158659) |
zebrafish
(Danio rerio) |
Actinopterygii |
lhb6 |
luteinizing hormone, beta polypeptide |
40(a) |
1 → many |
Zv9_scaffold3525(54871-57837) |
ENSEMBL Gene Tree for CGB8 (if available)
TreeFam Gene Tree for CGB8 (if available) |
Paralogs
for CGB8 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CGB8 gene
- CGB51 2 CGB1 2 TSHB2 FSHB2 CGB22 LHB2 ENSG000002673352 CGB72
- CGB12
8 SIMAP similar genes for CGB8 using alignment to 2 protein entries: CGHB_HUMAN (see all proteins):CGB CGB5 CGB2 CGB7 CGB1 LHB
FSHB TSHB
CGB8 for paralogs About GeneDecksing
|
Genomic Variants
for CGB8 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 19 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CGB8 (49550895 - 49552400 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CGB8
3 CNVs: 67577 5109 32261 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CGB8 |
|
Disorders
/ Diseases
for CGB8 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CGB8 for disorders About GeneDecksing
OMIM gene information: 608827
OMIM disorders: --
4  diseases for CGB8: About MalaCardsmixed ductal-endocrine carcinoma habitual abortion cryptococcosis carcinoma
1 disease from the University of Copenhagen DISEASES database for CGB8:Cryptococcosis Export disorders for CGB8 gene to outside databases
|
Publications
for CGB8 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CGB8 gene, integrated from 9 sources (see all 27):
(articles sorted by number of sources associating them with CGB8) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PubMed id 6194155)1, 2, 3 Policastro P....Boime I. (1983)
- A map of the hCG beta-LH beta gene cluster. (PubMed id 2422163)1, 2 Policastro P.F.... Boime I. (1986)
- Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. (PubMed id 6690982)1, 2 Talmadge K.... Fiddes J.C. (1984)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
- Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
- Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection. (PubMed id 11861891)2 Maston G.A. and Ruvolo M. (2002)
- Malignant transformation of nontrophoblastic cells is associated with the expression of chorionic gonadotropin beta genes normally transcribed in trophoblastic cells. (PubMed id 9012484)1 Bellet D....Vidaud M. (1997)
- Crystal structure of human chorionic gonadotropin. (PubMed id 8202136)2 Lapthorn A.J.... Isaacs N.W. (1994)
|
External Searches for CGB8 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
|
Genome Databases showing CGB8 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CGB8 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CGB8 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CGB8 | Pharmacogenomics, SNPs, Pathways | | Wikipedia | http://en.wikipedia.org/wiki/Human_chorionic_gonadotropin |
|
| | |
About This Section
| Patent Information for CGB8 gene:
Search GeneIP for patents involving CGB8
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CGB8 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CGB8 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CGB8 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CGB8 | | | OriGene Protein Over-expression Lysate for CGB8 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CGB8 | | Browse 3'-UTR reporter clones for miRNA target validation | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CGB8 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CGB8 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling | | | OriGene Custom Antibody Services for CGB8 | | OriGene Custom Protein Services for CGB8 | | | OriGene Custom Immunoassay Development | | |
| |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CGB8 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CGB8 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CGB8 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CGB8 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CGB8 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CGB8 |
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| | | | Search Tocris compounds for CGB8 |
| |  |  |  |  | | | | |
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 | | | | |  |  |  | | | | Search ThermoFisher Antibodies for CGB8 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CGB8 |
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