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Aliases for CGB8 Gene

Aliases for CGB8 Gene

  • Chorionic Gonadotropin Beta Subunit 8 2 3 5
  • Chorionic Gonadotropin, Beta Polypeptide 8 2
  • Chorionic Gonadotropin Chain Beta 4
  • Choriogonadotropin Subunit Beta 4
  • CGB3 CGB5 CGB8 4
  • CG-Beta 4
  • CGB 4

External Ids for CGB8 Gene

Previous GeneCards Identifiers for CGB8 Gene

  • GC19M050210
  • GC19M049919
  • GC19M054226
  • GC19M054243
  • GC19M054245
  • GC19M054247
  • GC19M054227
  • GC19M054228
  • GC19M054229
  • GC19M054248
  • GC19M049550
  • GC19M045927

Summaries for CGB8 Gene

Entrez Gene Summary for CGB8 Gene

  • This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 8 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CGB8 Gene

CGB8 (Chorionic Gonadotropin Beta Subunit 8) is a Protein Coding gene. Diseases associated with CGB8 include Ulcerative Stomatitis and Mixed Ductal-Endocrine Carcinoma. Among its related pathways are Transport to the Golgi and subsequent modification and Peptide hormone metabolism. GO annotations related to this gene include hormone activity. An important paralog of this gene is CGB3.

UniProtKB/Swiss-Prot for CGB8 Gene

  • Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha- subunit is identical to the pituitary gonadotropin hormones (LH, FSH and TSH). The beta-subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGB8 Gene

Genomics for CGB8 Gene

Regulatory Elements for CGB8 Gene

Enhancers for CGB8 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CGB8 on UCSC Golden Path with GeneCards custom track

Genomic Location for CGB8 Gene

Chromosome:
19
Start:
49,047,638 bp from pter
End:
49,049,111 bp from pter
Size:
1,474 bases
Orientation:
Minus strand

Genomic View for CGB8 Gene

Genes around CGB8 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGB8 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGB8 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGB8 Gene

Proteins for CGB8 Gene

  • Protein details for CGB8 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DN86-CGB3_HUMAN
    Recommended name:
    Choriogonadotropin subunit beta 3
    Protein Accession:
    P0DN86
    Secondary Accessions:
    • A1A5E0
    • B9ZVP5
    • P01233
    • Q13991
    • Q14000
    • Q3KPI3
    • Q3SY41
    • Q8WTT5
    • Q8WXL1
    • Q8WXL2
    • Q8WXL3
    • Q8WXL4

    Protein attributes for CGB8 Gene

    Size:
    165 amino acids
    Molecular mass:
    17739 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain identical to LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones.
    • Heterodimer of a common alpha chain identical to LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones.
    • Heterodimer of a common alpha chain identical to LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones.
    Miscellaneous:
    • Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific CGB proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8).
    SequenceCaution:
    • Sequence=CAA25068.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA25069.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CGB8 Gene

    Alternative splice isoforms for CGB8 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CGB8 Gene

Post-translational modifications for CGB8 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CGB8 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CGB8 Gene

Domains & Families for CGB8 Gene

Protein Domains for CGB8 Gene

Suggested Antigen Peptide Sequences for CGB8 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0DN86

UniProtKB/Swiss-Prot:

CGB3_HUMAN :
  • Belongs to the glycoprotein hormones subunit beta family.
Family:
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with CGB8: view

No data available for Gene Families for CGB8 Gene

Function for CGB8 Gene

Molecular function for CGB8 Gene

UniProtKB/Swiss-Prot Function:
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha- subunit is identical to the pituitary gonadotropin hormones (LH, FSH and TSH). The beta-subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
genes like me logo Genes that share phenotypes with CGB8: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CGB8 Gene

Localization for CGB8 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGB8 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CGB8 Gene COMPARTMENTS Subcellular localization image for CGB8 gene
Compartment Confidence
extracellular 5
cytosol 3
golgi apparatus 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CGB8 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CGB8: view

Pathways & Interactions for CGB8 Gene

genes like me logo Genes that share pathways with CGB8: view

Pathways by source for CGB8 Gene

Interacting Proteins for CGB8 Gene

STRING Interaction Network Preview (showing 4 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000403649%0d%0a9606.ENSP00000358595%0d%0a9606.ENSP00000348307%0d%0a9606.ENSP00000312027%0d%0a9606.ENSP00000305529%0d%0a
Selected Interacting proteins: ENSP00000403649 for CGB8 Gene via STRING

SIGNOR curated interactions for CGB8 Gene

Activates:

Gene Ontology (GO) - Biological Process for CGB8 Gene

None

Drugs & Compounds for CGB8 Gene

(1) Drugs for CGB8 Gene - From: ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Luteinizing hormone releasing hormone human acetate salt (LHRH) Pharma 0

(1) ApexBio Compounds for CGB8 Gene

genes like me logo Genes that share compounds with CGB8: view

Transcripts for CGB8 Gene

mRNA/cDNA for CGB8 Gene

(1) REFSEQ mRNAs :
(247) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CGB8 Gene

No ASD Table

Relevant External Links for CGB8 Gene

GeneLoc Exon Structure for
CGB8
ECgene alternative splicing isoforms for
CGB8

Expression for CGB8 Gene

mRNA expression in normal human tissues for CGB8 Gene

NURSA nuclear receptor signaling pathways regulating expression of CGB8 Gene:

CGB8

mRNA Expression by UniProt/SwissProt for CGB8 Gene:

P0DN86-CGB3_HUMAN
Tissue specificity: High expression in the placenta throughout pregnancy.
genes like me logo Genes that share expression patterns with CGB8: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CGB8 Gene

Orthologs for CGB8 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGB8 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LHB 35
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LHB 35
  • 64 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia LHB 35
  • 55 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Lhb 35
  • 62 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 97 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii lhb 35
  • 39 (a)
OneToMany
Species where no ortholog for CGB8 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGB8 Gene

ENSEMBL:
Gene Tree for CGB8 (if available)
TreeFam:
Gene Tree for CGB8 (if available)

Paralogs for CGB8 Gene

Paralogs for CGB8 Gene

(8) SIMAP similar genes for CGB8 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CGB8: view

Variants for CGB8 Gene

Sequence variations from dbSNP and Humsavar for CGB8 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs3179073 -- 49,048,761(-) GTACA(A/C/T)GAGGC utr-variant-5-prime
rs3179074 -- 49,048,748(-) GGGAC(A/G)CACCA utr-variant-5-prime
rs4002416 -- 49,048,566(+) CATTT(C/T)AGATC intron-variant
rs4002417 -- 49,048,578(+) CCACC(C/T)TCAGG intron-variant
rs4002419 -- 49,050,875(+) GCACA(C/T)GGAGA upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CGB8 Gene

Variant ID Type Subtype PubMed ID
dgv592n67 CNV loss 20364138
esv22462 CNV gain 19812545
nsv833857 CNV loss 17160897
nsv833859 CNV loss 17160897
nsv953598 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495
nsv978832 CNV duplication 23825009

Variation tolerance for CGB8 Gene

Gene Damage Index Score: 0.09; 2.03% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CGB8 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CGB8

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGB8 Gene

Disorders for CGB8 Gene

MalaCards: The human disease database

(3) MalaCards diseases for CGB8 Gene - From: DISEASES

Disorder Aliases PubMed IDs
ulcerative stomatitis
  • stomatitis ulcerative
mixed ductal-endocrine carcinoma
3-methylcrotonyl-coa carboxylase deficiency
  • 3-methylcrotonylglycinuria
- elite association - COSMIC cancer census association via MalaCards
Search CGB8 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CGB8

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CGB8
genes like me logo Genes that share disorders with CGB8: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CGB8 Gene

Publications for CGB8 Gene

  1. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PMID: 6194155) Policastro P. … Boime I. (J. Biol. Chem. 1983) 2 3 4 65
  2. A map of the hCG beta-LH beta gene cluster. (PMID: 2422163) Policastro P.F. … Boime I. (J. Biol. Chem. 1986) 3 4 65
  3. Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. (PMID: 6690982) Talmadge K. … Fiddes J.C. (Nature 1984) 3 4 65
  4. Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues. (PMID: 18048458) Rull K. … Laan M. (Mol. Hum. Reprod. 2008) 22 65
  5. High divergence in primate-specific duplicated regions: human and chimpanzee chorionic gonadotropin beta genes. (PMID: 18606016) Hallast P. … Laan M. (BMC Evol. Biol. 2008) 22 65

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