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CGB8 Gene

protein-coding   GIFtS: 43
GCID: GC19M049550

Chorionic Gonadotropin, Beta Polypeptide 8

  See CGB8-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chorionic Gonadotropin, Beta Polypeptide 81 2
Chorionic Gonadotropin Beta 8 Subunit2
CG-beta3
CGB33
Chorionic Gonadotrophin Chain Beta3

External Ids:    HGNC: 164531   Entrez Gene: 941152   Ensembl: ENSG000002130307   OMIM: 6088275   UniProtKB: P012333   

Export aliases for CGB8 gene to outside databases

Previous GC identifers: GC19M050210 GC19M049919 GC19M054226 GC19M054243 GC19M054245 GC19M054247 GC19M054227 GC19M054228 GC19M054229 GC19M054248 GC19M045927


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CGB8 Gene:
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 8 subunit of chorionic
gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta
subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and
stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta
subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and
contiguous with the luteinizing hormone beta subunit gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CGB8 Gene:
CGB8 (chorionic gonadotropin, beta polypeptide 8) is a protein-coding gene. Diseases associated with CGB8 include cryptococcosis. An important paralog of this gene is TSHB.

UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CGB8 gene promoter:
         NF-1   NF-1/L   Pax-5   p53   POU3F1   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCGB8 promoter sequence
   Search Chromatin IP Primers for CGB8

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CGB8


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.32

CGB8 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CGB8 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049550:  view genomic region     (about GC identifiers)

Start:
49,550,895 bp from pter      End:
49,552,400 bp from pter
Size:
1,506 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233 (See protein sequence)
Recommended Name: Choriogonadotropin subunit beta precursor  
Size: 165 amino acids; 17739 Da
Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to
thyrotropin, lutropin, follitropin and gonadotropin
Developmental stage: Made by the first trimester placenta
Sequence caution: Sequence=CAA25068.1; Type=Erroneous initiation; Sequence=CAA25069.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for CGB8:
1HCN (3D)        1HRP (3D)        1QFW (3D)        1XUL (3D)    
Secondary accessions: A1A5E0 B9ZVP5 Q13991 Q14000 Q3KPI3 Q3SY41 Q8WTT5 Q8WXL1 Q8WXL2 Q8WXL3
Q8WXL4
Alternative splicing: 2 isoforms:  P01233-1   P01233-2   (Ref.2 (CAA25069) sequence is in conflict in positions: 7:G->R, 9:A->V, 12:D->G)

Explore the universe of human proteins at neXtProt for CGB8: NX_P01233

Explore proteomics data for CGB8 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CGB8 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149439.1  
    ENSEMBL proteins: 
     ENSP00000403649   ENSP00000347582  
    Reactome Protein details: P01233

    CGB8 Human Recombinant Protein Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for CGB8 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR018245 Gonadotropin_bsu_CS
     IPR001545 Gonadotropin_bsu
     IPR006208 Cys_knot

    Graphical View of Domain Structure for InterPro Entry P01233

    ProtoNet protein and cluster: P01233

    3 Blocks protein domains:
    IPB001545 Gonadotropin
    IPB002400 Growth factor cystine knot superfamily signature
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Similarity: Belongs to the glycoprotein hormones subunit beta family


    Find genes that share domains with CGB8           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CGHB_HUMAN, P01233
    Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity ----
         
    Find genes that share ontologies with CGB8           About GenesLikeMe


    Phenotypes:
         1 GenomeRNAi human phenotype for CGB8:
     Decreased Hepatitis C virus re 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CGB8
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CGHB_HUMAN, P01233: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol4
    endoplasmic reticulum1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----

    Find genes that share ontologies with CGB8           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CGB8 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Peptide hormone biosynthesis0.00
    Glycoprotein hormones0.00
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with CGB8           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for CGB8
        Glycoprotein hormones


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CGB8
    Interactions:

        Search GeneGlobe Interaction Network for CGB8

    STRING Interaction Network Preview (showing 5 interactants - click image to see 6)

    Selected Interacting proteins for CGB8 (P012332, 3 ENSP000003475824) via UniProtKB, MINT, STRING, and/or I2D (see all 10)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CGAP012152, 3, ENSP000003585954MINT-24926 I2D: score=5 STRING: ENSP00000358595
    CKBP122773I2D: score=1 
    EWSR1Q018443I2D: score=1 
    FSHBP012253I2D: score=1 
    LHCGRP228883I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process ----
    GO:0007165signal transduction ----
    GO:0007267cell-cell signaling ----
    GO:0007292female gamete generation ----
    GO:0016486peptide hormone processing ----

    Find genes that share ontologies with CGB8           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CGB8 (CGHB)

    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Pharmaceutical: Available under the names Novarel (Ferring) and Profasi (Serono). Used as adjunctive therapy in
    the treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting
    from caloric restriction, that it causes a more attractive or 'normal' distribution of fat, or that it decreases
    the hunger and discomfort associated with calorie-restricted diets



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CGB8 gene: 
    NM_033183.2  

    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000448456(uc002pmb.4) ENST00000355414
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat CGB8

    Selected AceView cDNA sequences (see all 247):

    AA331012 NM_033378 T50278 BC069367 AA330859 NM_033043 BC006290 CA944648 
    BC051378 BU752378 CR590789 BQ004068 BV177010 CR616977 BV199138 BU752736 
    AI149559 AI128424 AI417614 CF528653 BE733206 AI149072 CF528169 BQ003981 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CGB8 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CGB8 Expression
    About this image

    CGB8 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CGB8 Protein Expression

    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Tissue specificity: Placenta

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CGB8 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    36(a)
    1 → many
    6(80158039-80158659)
    zebrafish
    (Danio rerio)
    Actinopterygii lhb6
    luteinizing hormone, beta polypeptide
    39(a)
    1 → many
    Zv9_scaffold3525(54871-57837) ENSDARG00000035709
            Species with no ortholog for CGB8

    ENSEMBL Gene Tree for CGB8 (if available)
    TreeFam Gene Tree for CGB8 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CGB8 gene
    CGB51 2  CGB1 2  TSHB2  FSHB2  CGB22  LHB2  ENSG000002673352  CGB72  
    CGB12  
    8 SIMAP similar genes for CGB8 using alignment to 2 protein entries:     CGHB_HUMAN (see all proteins):
    CGB    CGB5    CGB1    CGB2    CGB7    LHB
    FSHB    TSHB

    Find genes that share paralogs with CGB8           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CGB8 (see all 128)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs21614121,2
    C,F--49550628(-) GGTGGT/CGGGCG 1 -- ds50011Minor allele frequency- C:0.49NA 120
    rs713527231,2
    C--49550846(+) ACCCAC/TCCTGT 1 -- ds50011Minor allele frequency- T:0.50NA 2
    rs713527251,2
    C--49550936(+) GTGTCC/TGAGGG 2 S syn11Minor allele frequency- T:0.50NA 2
    rs621278711,2
    C,F--49550972(+) AGGCTG/CGGGGG 2 /P syn11Minor allele frequency- C:0.17EU 367
    rs2000879151,2
    F--49551000(+) AGGAGT/GCCTGG 2 /D /A mis11Minor allele frequency- G:0.01EU 605
    rs2012104671,2
    F--49551513(+) CACACG/TGGGCA 2 P syn11Minor allele frequency- T:0.01EU 679
    rs2001938941,2
    F--49551556(+) TGGGGC/TGGCAC 2 H R mis11Minor allele frequency- T:0.00EU 641
    rs1512417441,2
    F--49551573(+) CGAAGC/TGGCTC 2 P syn11Minor allele frequency- T:0.03EU 500
    rs1450497521,2
    --49551693(+) CCCATC/TCCACG 1 -- int10--------
    rs40024161,2
    C--49551823(+) CATTTC/TAGATC 1 -- int11Minor allele frequency- T:0.00NA 2

    HapMap Linkage Disequilibrium report for CGB8 (49550895 - 49552400 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 9 variations for CGB8:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv833859CNV Loss17160897
    nsv912248CNV Loss21882294
    nsv833857CNV Loss17160897
    nsv912251CNV Loss21882294
    dgv3970n71CNV Loss21882294
    nsv912252CNV Loss21882294
    dgv592n67CNV Loss20364138
    esv22462CNV Gain19812545
    nsv9739CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608827    OMIM disorders: --

    1 disease for CGB8:    
    About MalaCards
    cryptococcosis

    1 disease from the University of Copenhagen DISEASES database for CGB8:
    Cryptococcosis

    Find genes that share disorders with CGB8           About GenesLikeMe


    Export disorders for CGB8 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CGB8 gene, integrated from 10 sources (see all 27):
    (articles sorted by number of sources associating them with CGB8)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PubMed id 6194155)1, 2, 3 Policastro P....Boime I. (J. Biol. Chem. 1983)
    2. A map of the hCG beta-LH beta gene cluster. (PubMed id 2422163)1, 2 Policastro P.F.... Boime I. (J. Biol. Chem. 1986)
    3. Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. (PubMed id 6690982)1, 2 Talmadge K.... Fiddes J.C. (Nature 1984)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (Nat. Genet. 2004)
    6. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (Nature 2004)
    7. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002)
    8. Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection. (PubMed id 11861891)2 Maston G.A. and Ruvolo M. (Mol. Biol. Evol. 2002)
    9. Malignant transformation of nontrophoblastic cells is associated with the expression of chorionic gonadotropin beta genes normally transcribed in trophoblastic cells. (PubMed id 9012484)1 Bellet D....Vidaud M. (Cancer Res. 1997)
    10. Crystal structure of human chorionic gonadotropin. (PubMed id 8202136)2 Lapthorn A.J.... Isaacs N.W. (Nature 1994)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 94115 HGNC: 16453 AceView: CGB5andCGB2 Ensembl:ENSG00000213030 euGenes: HUgn94115
    ECgene: CGB8 H-InvDB: CGB8

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CGB8 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Human_chorionic_gonadotropin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CGB8 gene:
    Search GeneIP for patents involving CGB8

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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