Set Analyses:
Advanced Search

Advanced Search

 
Search By
Section (entire)
for


 



CGB7 Gene

protein-coding   GIFtS: 46
GCID: GC19M049557

Chorionic Gonadotropin, Beta Polypeptide 7

  See CGB7-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

TryGeneCards Plus

Aliases
Chorionic Gonadotropin, Beta Polypeptide 71 2     CG-beta3
CGB62 5     CGB33
CG-beta-a2     Chorionic Gonadotrophin Chain Beta3
Chorionic Gonadotropin Beta 7 Subunit2     

External Ids:    HGNC: 164511   Entrez Gene: 940272   Ensembl: ENSG000001963377   OMIM: 6088265   UniProtKB: P012333   

Export aliases for CGB7 gene to outside databases

Previous GC identifers: GC19M050215 GC19M049920 GC19M054233 GC19M054242 GC19M054249 GC19M045934


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

TryGeneCards Plus

Entrez Gene summary for CGB7 Gene:
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 7 subunit of chorionic
gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta
subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and
stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta
subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and
contiguous with the luteinizing hormone beta subunit gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CGB7 Gene:
CGB7 (chorionic gonadotropin, beta polypeptide 7) is a protein-coding gene. Diseases associated with CGB7 include gestational choriocarcinoma, and nonseminomatous germ cell tumor. An important paralog of this gene is TSHB.

UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

Gene Wiki entry for CGB7 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
About This Section

TryGeneCards Plus
Regulatory elements:
   Regulatory transcription factor binding sites in the CGB7 gene promoter:
         Pax-5   p53   NF-YA   Egr-4   NF-YB   CBF-A   CBF-B   CP1A   NF-Y   CBF(2)   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCGB7 promoter sequence
   Search Chromatin IP Primers for CGB7

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CGB7


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.32

CGB7 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CGB7 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049557:  view genomic region     (about GC identifiers)

Start:
49,557,531 bp from pter      End:
49,562,117 bp from pter
Size:
4,587 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
About This Section

TryGeneCards Plus

UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233 (See protein sequence)
Recommended Name: Choriogonadotropin subunit beta precursor  
Size: 165 amino acids; 17739 Da
Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to
thyrotropin, lutropin, follitropin and gonadotropin
Developmental stage: Made by the first trimester placenta
Sequence caution: Sequence=CAA25068.1; Type=Erroneous initiation; Sequence=CAA25069.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for CGB7:
1HCN (3D)        1HRP (3D)        1QFW (3D)        1XUL (3D)    
Secondary accessions: A1A5E0 B9ZVP5 Q13991 Q14000 Q3KPI3 Q3SY41 Q8WTT5 Q8WXL1 Q8WXL2 Q8WXL3
Q8WXL4
Alternative splicing: 2 isoforms:  P01233-1   P01233-2   (Ref.2 (CAA25069) sequence is in conflict in positions: 7:G->R, 9:A->V, 12:D->G)

Explore the universe of human proteins at neXtProt for CGB7: NX_P01233

Explore proteomics data for CGB7 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CGB7 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149133.1  
    ENSEMBL proteins: 
     ENSP00000469076   ENSP00000470813   ENSP00000366493   ENSP00000348545  
    Reactome Protein details: P01233

    CGB7 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Browse OriGene full length recombinant human proteins expressed in human HEK293 cells
    OriGene Protein Over-expression Lysate for CGB7
    OriGene Custom MassSpec
    OriGene Custom Protein Services for CGB7
    GenScript Custom Purified and Recombinant Proteins Services for CGB7
    Novus Biologicals CGB7 Protein
    Novus Biologicals CGB7 Lysate
    Browse Sino Biological Recombinant Proteins
    Sino Biological Cell Lysate for CGB7
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp.

     
    Search eBioscience for Proteins for CGB7 

    CGB7 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CGB7
    Browse R&D Systems for Antibodies
    Browse OriGene Antibodies
    OriGene Custom Antibody Services for CGB7
    Novus Biologicals CGB7 Antibodies
    Search for Antibodies for CGB7 at Abcam
    Browse Antibodies at Cloud-Clone Corp.
    ThermoFisher Antibodies for CGB7
    LSBio Antibodies in human, mouse, rat for CGB7

    CGB7 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CGB7
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CGB7
    Browse Enzo Life Sciences for kits & assays
    Browse ELISAs at Cloud-Clone Corp.
    Browse CLIAs at Cloud-Clone Corp.
    Search eBioscience for ELISAs for CGB7 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    TryGeneCards Plus
    3 InterPro protein domains:
     IPR018245 Gonadotropin_bsu_CS
     IPR001545 Gonadotropin_bsu
     IPR006208 Cys_knot

    Graphical View of Domain Structure for InterPro Entry P01233

    ProtoNet protein and cluster: P01233

    3 Blocks protein domains:
    IPB001545 Gonadotropin
    IPB002400 Growth factor cystine knot superfamily signature
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Similarity: Belongs to the glycoprotein hormones subunit beta family


    Find genes that share domains with CGB7           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CGHB_HUMAN, P01233
    Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity ----
         
    Find genes that share ontologies with CGB7           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CGB7
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CGB7

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CGB7
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CGB7

    miRNA
    Products:
        
    Block miRNA regulation of human, mouse, rat CGB7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CGB7
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CGB7
    Predesigned siRNA for gene silencing in human, mouse, rat CGB7

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CGB7

    Clone
    Products:
         
    OriGene clones in human, mouse for CGB7 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CGB7 (NM_033142)
    Sino Biological Human cDNA Clone for CGB7
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CGB7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CGB7

    Cell Line
    Products:
         
    GenScript Custom overexpressing Cell Line Services for CGB7
    Browse ESI BIO Cell Lines and PureStem Progenitors for CGB7 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGB7


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
    About This Section

    TryGeneCards Plus

    Subcellular locations from UniProtKB/Swiss-Prot
    CGHB_HUMAN, P01233: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol4
    endoplasmic reticulum1
    nucleus1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----

    Find genes that share ontologies with CGB7           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
    About This Section

    TryGeneCards Plus

    SuperPaths for CGB7 About    
    See pathways by source

    SuperPathContained pathways About
    1Selected targets of Oct 3 4
    Selected targets of Oct 3 4


    Find genes that share SuperPaths with CGB7           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CGB7
        Glycoprotein hormones


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CGB7
    Interactions:

        Search GeneGlobe Interaction Network for CGB7

    STRING Interaction Network Preview (showing 2 interactants - click image to see more details)

    Selected Interacting proteins for CGB7 (P012332, 3 ENSP000003485454) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CGAP012152, 3MINT-24926 I2D: score=5 
    CKBP122773I2D: score=1 
    EWSR1Q018443I2D: score=1 
    FSHBP012253I2D: score=1 
    LHCGRP228883I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process ----
    GO:0007165signal transduction ----
    GO:0007267cell-cell signaling ----
    GO:0007292female gamete generation ----
    GO:0016486peptide hormone processing ----

    Find genes that share ontologies with CGB7           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
    About This Section

    TryGeneCards Plus
    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CGB7 (CGHB)

    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Pharmaceutical: Available under the names Novarel (Ferring) and Profasi (Serono). Used as adjunctive therapy in
    the treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting
    from caloric restriction, that it causes a more attractive or 'normal' distribution of fat, or that it decreases
    the hunger and discomfort associated with calorie-restricted diets

    Selected Novoseek inferred chemical compound relationships for CGB7 gene (see all 14)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oestriol 77 10 10073912 (1), 15512289 (1), 9203211 (1), 10416963 (1) (see all 8)
    methotrexate 49.9 9 9740461 (1), 17356825 (1), 18751412 (1), 14530615 (1) (see all 7)
    ctp 49.4 8 17092639 (3), 16636974 (1), 16644100 (1), 1379674 (1) (see all 5)
    progesterone 34.9 10 1379268 (2), 10656995 (1), 1379267 (1), 12581973 (1) (see all 9)
    etoposide 25 1 7532652 (1)
    bleomycin 20.2 1 18751412 (1)
    cisplatin 14.3 1 18751412 (1)
    gnrh 4.32 1 8096491 (1)
    estradiol 0 3 1833973 (2), 11078984 (1)
    lactate 0 3 17122498 (1), 16474737 (1), 1716953 (1)



    Find genes that share compounds with CGB7           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
    About This Section

    TryGeneCards Plus

    REFSEQ mRNAs for CGB7 gene: 
    NM_033142.1  

    6 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000596965 ENST00000597853 ENST00000593309 ENST00000598442 ENST00000377280
    ENST00000356213(uc002pmc.3 uc002pmd.3 uc002pme.3 uc010emq.1)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CGB7 using miScript Target Protectors
    Search for qRT-PCR Assays for microRNAs that regulate CGB7
    Browse SwitchGear 3'UTR luciferase reporter plasmids
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CGB7
    Predesigned siRNA for gene silencing in human, mouse, rat CGB7
    Clone
    Products:
         
    OriGene clones in human, mouse for CGB7 (see all 5)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CGB7 (NM_033142)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CGB7
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CGB7
    Primer
    Products:
        
    OriGene qPCR primer pairs and template standards for CGB7
    OriGene qSTAR qPCR primer pairs in human, mouse for CGB7
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CGB7
      QuantiTect SYBR Green Assays in human, mouse, rat CGB7
      QuantiFast Probe-based Assays in human, mouse, rat CGB7

    Selected AceView cDNA sequences (see all 409):

    BM977377 CF527874 CF527893 CF528345 CF528240 CF527851 BU752328 BQ007403 
    AI188689 CF527834 BU752304 CF528125 CF527795 CF528337 H95121 AA330859 
    BQ007360 CF527846 N27073 AU138071 CF527771 AI189442 CF528112 BX359929 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    TryGeneCards Plus

    CGB7 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CGB7 Expression
    About this image

    CGB7 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CGB7 Protein Expression

    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Tissue specificity: Placenta

        Custom PCR Arrays for CGB7
    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CGB7
    OriGene qSTAR qPCR primer pairs in human, mouse for CGB7
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CGB7
    QuantiTect SYBR Green Assays in human, mouse, rat CGB7
    QuantiFast Probe-based Assays in human, mouse, rat CGB7
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGB7

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    TryGeneCards Plus

    This gene was present in the common ancestor of chordates.

    Orthologs for CGB7 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    37(a)
    1 → many
    6(80158039-80158659)
    zebrafish
    (Danio rerio)
    Actinopterygii lhb6
    luteinizing hormone, beta polypeptide
    39(a)
    1 → many
    Zv9_scaffold3525(54871-57837) ENSDARG00000035709
            Species with no ortholog for CGB7

    ENSEMBL Gene Tree for CGB7 (if available)
    TreeFam Gene Tree for CGB7 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

    TryGeneCards Plus
    Paralogs for CGB7 gene
    TSHB2  FSHB2  CGB22  LHB2  CGB82  ENSG000002673352  CGB52  CGB2  
    CGB12  
    8 SIMAP similar genes for CGB7 using alignment to 2 protein entries:     CGHB_HUMAN (see all proteins):
    CGB8    CGB2    CGB    CGB5    CGB1    LHB
    FSHB    TSHB

    Find genes that share paralogs with CGB7           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
    About This Section

    TryGeneCards Plus

    Selected SNPs for CGB7 (see all 135)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1504109931,2
    --49557049(+) ACCTCC/TTGAGC 1 -- ds50010--------
    rs3733373451,2
    C--49557117(+) TCTTT-/TTTTTT 1 -- ds50010--------
    rs1115545681,2
    C,F--49557145(+) GTCTCG/CCTCCG 1 -- ds50011Minor allele frequency- C:0.50CSA 2
    rs801985561,2
    C--49557150(+) GCTCCG/ATCATG 1 -- ds50011Minor allele frequency- A:0.50CSA 2
    rs1451680861,2
    --49557202(+) TCCCCC/GTCCCA 1 -- ds50010--------
    rs789925681,2
    C--49557355(+) TGATCC/AGCCTG 1 -- ds50011Minor allele frequency- A:0.00CSA 1
    rs353361691,2
    C,F--49557372(-) ACTTTG/CGGAGG 1 -- ds50013Minor allele frequency- C:0.32EU WA EA 190
    rs1452453341,2
    C--49557392(+) ACAGGC/GGTGAG 1 -- ds50010--------
    rs355947691,2
    C,F--49557408(-) CGGCKG/AGGCGC 1 -- ds50013Minor allele frequency- A:0.01EU WA EA 190
    rs347264181,2
    C,F--49557409(-) ACGGCG/TGGGCG 1 -- ds50016Minor allele frequency- T:0.36EU WA EA NA CSA 195

    HapMap Linkage Disequilibrium report for CGB7 (49557531 - 49562117 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CGB7 (see all 11):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2675899CNV Deletion23128226
    nsv833859CNV Loss17160897
    nsv912248CNV Loss21882294
    nsv833857CNV Loss17160897
    nsv912251CNV Loss21882294
    dgv3970n71CNV Loss21882294
    nsv912252CNV Loss21882294
    dgv592n67CNV Loss20364138
    nsv520785CNV Gain19592680
    esv22462CNV Gain19812545

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CGB7
    DNA2.0 Custom Variant and Variant Library Synthesis for CGB7

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

    TryGeneCards Plus
    OMIM gene information: 608826    OMIM disorders: --

    8 diseases for CGB7:    
    About MalaCards
    gestational choriocarcinoma    nonseminomatous germ cell tumor    seminoma    sacrococcygeal teratoma
    choriocarcinoma    cryptococcosis    bladder carcinoma    neural tube defects

    1 disease from the University of Copenhagen DISEASES database for CGB7:
    Cryptococcosis

    Find genes that share disorders with CGB7           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CGB7 gene (see all 32)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    down syndrome 87.7 53 7693095 (3), 7506599 (2), 10073912 (1), 11559909 (1) (see all 47)
    choriocarcinoma 73.4 9 1649392 (1), 20415215 (1), 10341006 (1), 8883763 (1) (see all 6)
    pregnancy ectopic 69.5 13 1379268 (2), 1826038 (1), 8501201 (1), 16123088 (1) (see all 11)
    trisomy 66.6 15 7506599 (4), 9238717 (1), 20101668 (1), 11559905 (1) (see all 12)
    pregnancy tubal 59.4 3 7769076 (1), 8530682 (1), 8671345 (1)
    seminoma 53.2 4 11005453 (1), 18578862 (1), 1716953 (1), 8653285 (1)
    hydatidiform mole 51.3 2 8883763 (2)
    teratoma 43.6 1 9021828 (1)
    carcinoma embryonal 33.7 1 11005453 (1)
    chromosomal aberrations 31.7 2 9313073 (1), 8284287 (1)


    Export disorders for CGB7 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    TryGeneCards Plus

    PubMed articles for CGB7 gene, integrated from 10 sources (see all 268):
    (articles sorted by number of sources associating them with CGB7)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PubMed id 6194155)1, 2, 3 Policastro P....Boime I. (J. Biol. Chem. 1983)
    2. Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection. (PubMed id 11861891)1, 2, 9 Maston G.A. and Ruvolo M. (Mol. Biol. Evol. 2002)
    3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    5. Crystal structure of human chorionic gonadotropin. (PubMed id 8202136)1, 2 Lapthorn A.J.... Isaacs N.W. (Nature 1994)
    6. Site-specific N-glycosylation of human chorionic gonadotrophin -- structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy. (PubMed id 1820200)1, 2 Weisshaar G.... Renwick A.G.C. (Glycobiology 1991)
    7. Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form. (PubMed id 1688430)1, 2 Saccuzo Beebe J.... Ruddon R.W. (J. Biol. Chem. 1990)
    8. A map of the hCG beta-LH beta gene cluster. (PubMed id 2422163)1, 2 Policastro P.F.... Boime I. (J. Biol. Chem. 1986)
    9. Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. (PubMed id 6690982)1, 2 Talmadge K.... Fiddes J.C. (Nature 1984)
    10. Assignment of disulfide bonds in the beta subunit of human chorionic gonadotropin. (PubMed id 7240231)1, 2 Mise T. and Bahl O.P. (J. Biol. Chem. 1981)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

    TryGeneCards Plus
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

    TryGeneCards Plus
    Entrez Gene: 94027 HGNC: 16451 AceView: CGB_ Ensembl:ENSG00000196337 euGenes: HUgn94027
    ECgene: CGB7 H-InvDB: CGB7

    (According to HUGE)
    About This Section

    TryGeneCards Plus
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

    TryGeneCards Plus
    NameDescription
    PharmGKB entry for CGB7 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Human_chorionic_gonadotropin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

    TryGeneCards Plus
    Patent Information for CGB7 gene:
    Search GeneIP for patents involving CGB7

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
    About This Section

    TryGeneCards Plus

     Browse Small Molecules at EMD Millipore
     Browse Purified and Recombinant Proteins at EMD Millipore
     Browse Kits and Assays available from EMD Millipore
     EMD Millipore Mono- and Polyclonal Antibodies for the study of CGB7
     
     EMD Millipore genomic analysis products

      
     Browse Antibodies   Browse Cell Culture Products  
     Browse ELISAs   Browse Flow Cytometry Kits  
     Browse Primer Pairs   Browse Enzyme Activity Assays/Reagents  
     Browse ELISpot/FluoroSpot Kits/Development Modules   Browse TFB/Immunoprecipitation Assays  
     Browse Apoptosis Detection Kits/Reagents   Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents  
     Browse DNA Damage/Repair Kits/Reagents   Browse Luminex Assays  
     Browse Cell Selection/Detection Kits/Reagents   Browse Secondary Antibodies/Controls/Staining Reagents  
     Browse Recombinant/Natural Proteins   Browse Stem Cell Products  
     Browse cDNA Clones   Browse Proteome Profiler Antibody Arrays  
     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CGB7  
     OriGene qPCR primer pairs and template standards for CGB7   OriGene Protein Over-expression Lysate for CGB7  
     OriGene Custom Mass Spec   OriGene clones in human, mouse for CGB7  
     OriGene qSTAR qPCR primer pairs in human, mouse for CGB7   Browse OriGene full length recombinant human proteins expressed in human HEK293 cells  
     Browse OriGene ORF clones   OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling  
     OriGene Custom Antibody Services for CGB7   OriGene Custom Protein Services for CGB7  

     
     
     Block miRNA regulation of human, mouse, rat CGB7 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CGB7
     DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CGB7 Predesigned siRNA for gene silencing in human, mouse, rat CGB7
     QuantiFast Probe-based Assays in human, mouse, rat CGB7 QuantiTect SYBR Green Assays in human, mouse, rat CGB7
     Custom PCR Arrays for CGB7 Search Chromatin IP Primers for CGB7
     Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CGB7 Search GeneGlobe Interaction Network for CGB7
     Regulatory tfbs in CGB7 promoter
     GenScript Custom Purified and Recombinant Proteins Services for CGB7 GenScript cDNA clones with any tag delivered in your preferred vector for CGB7
     GenScript Custom Assay Services for CGB7 GenScript Custom overexpressing Cell Line Services for CGB7
     CloneReady with Over 120,000 Genes  Gene Synthesis: Any Gene in Any Vector
     Vector-based siRNA and miRNA, Ready for Transfection Gene Mutant Library, Variants up to 10^11
     Plasmid Preparation Custom Peptide Services
     Search for Antibodies & Assays

     Search Tocris compounds for CGB7 (CGHB)
     Browse Sino Biological Proteins
     Cell Lysates for CGB7
     cDNA Clones for CGB7
     4000+ Proteins
     Search Sino Biological for antibodies, proteins & pathways
     Protein Production Services
     Transfection Reagents
     Protein A/G/L resins
     Isotyping reagents
     Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

     Novus Tissue Slides
     CGB7 antibodies
     CGB7 proteins
     CGB7 lysates
     Search for Antibodies for CGB7 at Abcam
     See all of Abcam's Antibodies, Kits and Proteins for CGB7
     Custom Antibody / Protein Production Service
     Bulk Purchasing
     Advantages of Rabbit Monoclonal antibodies
     Abcam protocols and scientific support
     Browse ProSpec Recombinant Proteins
     Browse Proteins at Cloud-Clone Corp.
     Browse Antibodies at Cloud-Clone Corp.
     Browse ELISAs at Cloud-Clone Corp.
     Browse CLIAs at Cloud-Clone Corp.



     Browse ESI BIO Cell Lines and PureStem Progenitors for CGB7
     Gene Synthesis
     Protein Engineering
     Variant Library Synthesis
     Codon Optimization
     Protein Production and Purification
     Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGB7
     Browse SwitchGear 3'UTR luciferase reporter plasmids for CGB7
     SwitchGear Promoter luciferase reporter plasmids for CGB7
     ThermoFisher Antibodies for CGB7
     Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CGB7
     inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CGB7
     inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CGB7
     LSBio Antibodies in human, mouse, rat for CGB7
    Customized transgenic rodents for:
     Humanization
     Biomarker expression
     Off-target effect monitoring
     Translational medicine
     Tissue-specific gene expresssion
     Time-controlled gene expresssion
     Browse compounds at ApexBio
     Search Addgene for plasmids for CGB7
      Search eBioscience for proteins for CGB7
      Search eBioscience for elisas for CGB7
      eBioscience FlowRNA Probe Sets
           
    GeneCards Homepage - Last full update: 7 May 2014 - Incrementals: 9 May 2014 , 2 Jun 2014 , 26 Jun 2014 , 30 Jun 2014 , 21 Aug 2014 , 8 Sep 2014

    View Random Gene

    Category
    (GIFtS: )
    GIFtS Group
    The GeneCards human gene database gene index: 1 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


    Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

    Hot genes      Disease genes      CGB7 gene at Home site.
    Version: 3.12.224 13 Oct 2014
    hostname: 356980-web2.xennexinc.com index build: 128 solr: 1.4