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Aliases for CGB7 Gene

Aliases for CGB7 Gene

  • Chorionic Gonadotropin Beta Subunit 7 2 3 5
  • Chorionic Gonadotropin, Beta Polypeptide 7 2 3
  • Chorionic Gonadotropin Beta 7 Subunit 3
  • Choriogonadotropin Subunit Beta 7 3
  • CG-Beta-A 3
  • CGB6 3

External Ids for CGB7 Gene

Previous GeneCards Identifiers for CGB7 Gene

  • GC19M050215
  • GC19M049920
  • GC19M054233
  • GC19M054242
  • GC19M054249
  • GC19M049557
  • GC19M045934

Summaries for CGB7 Gene

Entrez Gene Summary for CGB7 Gene

  • This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 7 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CGB7 Gene

CGB7 (Chorionic Gonadotropin Beta Subunit 7) is a Protein Coding gene. Diseases associated with CGB7 include Trisomy 22 and Sacrococcygeal Teratoma. GO annotations related to this gene include hormone activity. An important paralog of this gene is CGB5.

UniProtKB/Swiss-Prot for CGB7 Gene

  • Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

Gene Wiki entry for CGB7 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGB7 Gene

Genomics for CGB7 Gene

Regulatory Elements for CGB7 Gene

Enhancers for CGB7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G048977 1.8 FANTOM5 Ensembl ENCODE dbSUPER 10.8 +79.7 79714 2.9 PKNOX1 ATF1 SIN3A GLIS2 ZNF143 FOS SP3 JUNB TSHZ1 ZNF623 NUCB1-AS1 NUCB1 KCNA7 TULP2 CGB7 NTF4 C19orf73 FUT1 GC19P048966 RUVBL2
GH19G048988 1.6 FANTOM5 ENCODE 11.6 +66.8 66807 7.2 CREB3L1 MLX AGO1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 GRWD1 NUP62 PRR12 SNORD35A PIH1D1 KDELR1 AKT1S1 ALDH16A1 SNORD35B LOC101059948
GH19G049207 1.6 FANTOM5 Ensembl ENCODE 11.3 -149.5 -149472 1.4 PKNOX1 ATF1 ARNT ARID4B SIN3A ZNF2 ZNF48 ZNF121 FOS SP5 PPP1R15A CD37 SNRNP70 PPFIA3 C19orf73 LIN7B NTF4 CGB7 SLC6A16 KCNA7
GH19G049145 1.5 Ensembl ENCODE dbSUPER 11.5 -87.5 -87522 1.6 ATF1 ARNT ARID4B SIN3A ZNF121 GLIS2 ZNF143 SP3 REST ZNF592 PPFIA3 C19orf73 PRR12 LIN7B KCNA7 SNRNP70 NTF4 CGB7 CD37 SLC6A16
GH19G049135 1.5 Ensembl ENCODE dbSUPER 11.5 -77.6 -77639 1.6 HDGF ATF1 FOXA2 PKNOX1 ZFP64 SIN3A FEZF1 YY1 SLC30A9 ELK1 LIN7B SNRNP70 PPFIA3 NTF4 CGB7 KCNA7 CCDC155 NUCB1 TULP2 HRC
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CGB7 on UCSC Golden Path with GeneCards custom track

Genomic Location for CGB7 Gene

Chromosome:
19
Start:
49,054,274 bp from pter
End:
49,058,860 bp from pter
Size:
4,587 bases
Orientation:
Minus strand

Genomic View for CGB7 Gene

Genes around CGB7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGB7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGB7 Gene

Proteins for CGB7 Gene

  • Protein details for CGB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DN87-CGB7_HUMAN
    Recommended name:
    Choriogonadotropin subunit beta 7
    Protein Accession:
    P0DN87
    Secondary Accessions:
    • A1A5E0
    • B9ZVP5
    • P01233
    • Q13991
    • Q14000
    • Q3KPI3
    • Q3SY41
    • Q8WTT5
    • Q8WXL1
    • Q8WXL2
    • Q8WXL3
    • Q8WXL4

    Protein attributes for CGB7 Gene

    Size:
    165 amino acids
    Molecular mass:
    17757 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain identical in LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones and confers receptor and biological specificity.
    Miscellaneous:
    • Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8).

neXtProt entry for CGB7 Gene

Post-translational modifications for CGB7 Gene

No Post-translational modifications

Other Protein References for CGB7 Gene

No data available for DME Specific Peptides for CGB7 Gene

Domains & Families for CGB7 Gene

Graphical View of Domain Structure for InterPro Entry

P0DN87

UniProtKB/Swiss-Prot:

CGB7_HUMAN :
  • Belongs to the glycoprotein hormones subunit beta family.
Family:
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with CGB7: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CGB7 Gene

Function for CGB7 Gene

Molecular function for CGB7 Gene

UniProtKB/Swiss-Prot Function:
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

Gene Ontology (GO) - Molecular Function for CGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with CGB7: view

Phenotypes for CGB7 Gene

genes like me logo Genes that share phenotypes with CGB7: view

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CGB7 Gene

Localization for CGB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGB7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CGB7 gene
Compartment Confidence
extracellular 5
cytosol 3
golgi apparatus 2
nucleus 1
endoplasmic reticulum 1

Gene Ontology (GO) - Cellular Components for CGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CGB7: view

Pathways & Interactions for CGB7 Gene

No Data Available

Interacting Proteins for CGB7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366493%0d%0a9606.ENSP00000358595%0d%0a
Selected Interacting proteins: ENSP00000366493 for CGB7 Gene via STRING

Symbol External ID(s) Details
CGA

Gene Ontology (GO) - Biological Process for CGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 7723844
GO:0007165 signal transduction TAS 10468638
GO:0007267 cell-cell signaling TAS 6194155
GO:0007292 female gamete generation TAS 10468638
genes like me logo Genes that share ontologies with CGB7: view

No data available for Pathways by source and SIGNOR curated interactions for CGB7 Gene

Drugs & Compounds for CGB7 Gene

(10) Drugs for CGB7 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Luteinizing hormone releasing hormone human acetate salt (LHRH) Pharma 0

(5) Additional Compounds for CGB7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CGB7 Gene

genes like me logo Genes that share compounds with CGB7: view

Transcripts for CGB7 Gene

mRNA/cDNA for CGB7 Gene

Unigene Clusters for CGB7 Gene

Chorionic gonadotropin, beta polypeptide 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CGB7 Gene

No ASD Table

Relevant External Links for CGB7 Gene

GeneLoc Exon Structure for
CGB7
ECgene alternative splicing isoforms for
CGB7

Expression for CGB7 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CGB7 Gene

mRNA differential expression in normal tissues according to GTEx for CGB7 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x6.9), Skin - Sun Exposed (Lower leg) (x6.5), Prostate (x4.5), and Esophagus - Mucosa (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of CGB7 Gene:

CGB7

SOURCE GeneReport for Unigene cluster for CGB7 Gene:

Hs.681647

mRNA Expression by UniProt/SwissProt for CGB7 Gene:

P0DN87-CGB7_HUMAN
Tissue specificity: High expression in the placenta throughout pregnancy.

Evidence on tissue expression from TISSUES for CGB7 Gene

  • Eye(2.7)
  • Adrenal gland(2.2)
  • Nervous system(2.1)
genes like me logo Genes that share expression patterns with CGB7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CGB7 Gene

Orthologs for CGB7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGB7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CGB7 34 35
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia LHB 35
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LHB 35
  • 64 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Lhb 35
  • 62 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia LHB 35
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 37 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii lhb 35
  • 39 (a)
OneToMany
Species where no ortholog for CGB7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGB7 Gene

ENSEMBL:
Gene Tree for CGB7 (if available)
TreeFam:
Gene Tree for CGB7 (if available)

Paralogs for CGB7 Gene

Paralogs for CGB7 Gene

(8) SIMAP similar genes for CGB7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CGB7: view

Variants for CGB7 Gene

Sequence variations from dbSNP and Humsavar for CGB7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000289437 -- 49,055,296(+) GTCTG(C/T)CCCTT intron-variant
rs1000373517 -- 49,058,545(+) AATCC(C/G)CTTTT intron-variant, upstream-variant-2KB
rs1000476557 -- 49,058,905(+) CAGAG(A/G)CAGAG intron-variant, upstream-variant-2KB
rs1000744674 -- 49,057,748(+) CGTGG(A/T)TGCCC intron-variant
rs1000820047 -- 49,057,873(+) CGCCA(G/T)CGCCG intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CGB7 Gene

Variant ID Type Subtype PubMed ID
dgv592n67 CNV loss 20364138
esv22462 CNV gain 19812545
esv2675899 CNV deletion 23128226
esv3644611 CNV loss 21293372
esv3644612 CNV gain 21293372
nsv520785 CNV gain 19592680
nsv833857 CNV loss 17160897
nsv833859 CNV loss 17160897
nsv953598 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495
nsv978832 CNV duplication 23825009

Variation tolerance for CGB7 Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.71; 78.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CGB7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CGB7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGB7 Gene

Disorders for CGB7 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CGB7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
trisomy 22
  • chromosome 22 trisomy
sacrococcygeal teratoma
triploidy
  • chromosome triploidy syndrome
choriocarcinoma
  • chorioepithelioma
ectopic pregnancy
  • eccyesis
- elite association - COSMIC cancer census association via MalaCards
Search CGB7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CGB7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CGB7
genes like me logo Genes that share disorders with CGB7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CGB7 Gene

Publications for CGB7 Gene

  1. Expression of beta-subunit of HCG genes during normal and failed pregnancy. (PMID: 16123088) Rull K. … Laan M. (Hum. Reprod. 2005) 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection. (PMID: 11861891) Maston G.A. … Ruvolo M. (Mol. Biol. Evol. 2002) 3 22 64
  4. Malignant transformation of nontrophoblastic cells is associated with the expression of chorionic gonadotropin beta genes normally transcribed in trophoblastic cells. (PMID: 9012484) Bellet D. … Vidaud M. (Cancer Res. 1997) 3 22 64
  5. Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo. (PMID: 1371113) Bo M. … Boime I. (J. Biol. Chem. 1992) 3 22 64

Products for CGB7 Gene

Sources for CGB7 Gene

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