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Aliases for CGB7 Gene

Aliases for CGB7 Gene

  • Chorionic Gonadotropin Beta Subunit 7 2 3 5
  • Chorionic Gonadotropin, Beta Polypeptide 7 2 3
  • Chorionic Gonadotropin Beta 7 Subunit 3
  • Choriogonadotropin Subunit Beta 7 3
  • CG-Beta-A 3
  • CGB6 3

External Ids for CGB7 Gene

Previous GeneCards Identifiers for CGB7 Gene

  • GC19M050215
  • GC19M049920
  • GC19M054233
  • GC19M054242
  • GC19M054249
  • GC19M049557
  • GC19M045934

Summaries for CGB7 Gene

Entrez Gene Summary for CGB7 Gene

  • This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 7 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CGB7 Gene

CGB7 (Chorionic Gonadotropin Beta Subunit 7) is a Protein Coding gene. Diseases associated with CGB7 include Trisomy 22 and Choriocarcinoma. GO annotations related to this gene include hormone activity. An important paralog of this gene is CGB8.

UniProtKB/Swiss-Prot for CGB7 Gene

  • Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

Gene Wiki entry for CGB7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGB7 Gene

Genomics for CGB7 Gene

Regulatory Elements for CGB7 Gene

Enhancers for CGB7 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19F049038 0.6 ENCODE 17.7 +20.1 20062 0.2 SMARCE1 PKNOX1 ZIC2 KAT2B ARID1B ZNF121 JUND ATF3 IKZF1 GLIS1 CGB7 NTF4 RUVBL2 NTF6B SNAR-G1
GH19F049106 0.6 ENCODE 11.9 -48.0 -48005 0.6 CTCF HDAC1 ARID4B BACH1 SIN3A ZNF2 RAD21 ZNF316 GATA3 ZNF366 SNRNP70 CGB8 KCNA7 NTF4 CGB7 GC19P049111
GH19F049113 0.5 ENCODE 11.9 -55.6 -55620 2.2 HDGF ATF1 PKNOX1 ARNT CREB3L1 ARID4B SIN3A DMAP1 ZNF48 ETS1 TEAD2 GRWD1 PLEKHA4 KDELR1 ENSG00000268157 ADM5 CGB8 LIN7B SNRNP70 ENSG00000197813
GH19F049012 1 ENCODE 11.8 +44.8 44799 2.2 ESRRA ATF1 JUN KLF17 ZFHX2 ZNF366 POLR2A CREM ZNF652 ZBTB10 LOC101059948 CGB3 CGB7 NTF4 KCNA7 LIN7B C19orf73 PPFIA3 RUVBL2 NUCB1
GH19F048988 1.3 FANTOM5 Ensembl ENCODE 11.6 +66.8 66807 7.2 MLX CREB3L1 ZFP64 DMAP1 FEZF1 YY1 SLC30A9 ZNF143 ZNF263 SP3 GRWD1 TEAD2 NUP62 AKT1S1 KDELR1 ENSG00000268157 SNORD35A LOC101059948 PLEKHA4 PRR12
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CGB7 on UCSC Golden Path with GeneCards custom track

Promoters for CGB7 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000348126 860 401 BCOR KLF1 ZMYM3 KDM1A

Genomic Location for CGB7 Gene

Chromosome:
19
Start:
49,054,274 bp from pter
End:
49,058,860 bp from pter
Size:
4,587 bases
Orientation:
Minus strand

Genomic View for CGB7 Gene

Genes around CGB7 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGB7 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGB7 Gene

Proteins for CGB7 Gene

  • Protein details for CGB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DN87-CGB7_HUMAN
    Recommended name:
    Choriogonadotropin subunit beta 7
    Protein Accession:
    P0DN87
    Secondary Accessions:
    • A1A5E0
    • B9ZVP5
    • P01233
    • Q13991
    • Q14000
    • Q3KPI3
    • Q3SY41
    • Q8WTT5
    • Q8WXL1
    • Q8WXL2
    • Q8WXL3
    • Q8WXL4

    Protein attributes for CGB7 Gene

    Size:
    165 amino acids
    Molecular mass:
    17757 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain identical in LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones and confers receptor and biological specificity.
    Miscellaneous:
    • Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific hCGb proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8).

neXtProt entry for CGB7 Gene

Post-translational modifications for CGB7 Gene

No Post-translational modifications

Other Protein References for CGB7 Gene

No data available for DME Specific Peptides for CGB7 Gene

Domains & Families for CGB7 Gene

Graphical View of Domain Structure for InterPro Entry

P0DN87

UniProtKB/Swiss-Prot:

CGB7_HUMAN :
  • Belongs to the glycoprotein hormones subunit beta family.
Family:
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with CGB7: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CGB7 Gene

Function for CGB7 Gene

Molecular function for CGB7 Gene

UniProtKB/Swiss-Prot Function:
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role for pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

Gene Ontology (GO) - Molecular Function for CGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IEA --
genes like me logo Genes that share ontologies with CGB7: view

Phenotypes for CGB7 Gene

genes like me logo Genes that share phenotypes with CGB7: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CGB7 Gene

Localization for CGB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGB7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CGB7 Gene COMPARTMENTS Subcellular localization image for CGB7 gene
Compartment Confidence
extracellular 5
cytosol 3
golgi apparatus 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CGB7: view

Pathways & Interactions for CGB7 Gene

SuperPathways for CGB7 Gene

No Data Available

Interacting Proteins for CGB7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366493%0d%0a9606.ENSP00000358595%0d%0a
Selected Interacting proteins: ENSP00000366493 for CGB7 Gene via STRING

Symbol External ID(s) Details
CGA

Gene Ontology (GO) - Biological Process for CGB7 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CGB7 Gene

Drugs & Compounds for CGB7 Gene

(10) Drugs for CGB7 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Luteinizing hormone releasing hormone human acetate salt (LHRH) Pharma 0

(5) Additional Compounds for CGB7 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CGB7 Gene

genes like me logo Genes that share compounds with CGB7: view

Transcripts for CGB7 Gene

mRNA/cDNA for CGB7 Gene

Unigene Clusters for CGB7 Gene

Chorionic gonadotropin, beta polypeptide 7:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CGB7 Gene

No ASD Table

Relevant External Links for CGB7 Gene

GeneLoc Exon Structure for
CGB7
ECgene alternative splicing isoforms for
CGB7

Expression for CGB7 Gene

mRNA expression in normal human tissues for CGB7 Gene

mRNA differential expression in normal tissues according to GTEx for CGB7 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x6.9), Skin - Sun Exposed (Lower leg) (x6.5), Prostate (x4.5), and Esophagus - Mucosa (x4.1).

NURSA nuclear receptor signaling pathways regulating expression of CGB7 Gene:

CGB7

SOURCE GeneReport for Unigene cluster for CGB7 Gene:

Hs.681647

mRNA Expression by UniProt/SwissProt for CGB7 Gene:

P0DN87-CGB7_HUMAN
Tissue specificity: High expression in the placenta throughout pregnancy.
genes like me logo Genes that share expression patterns with CGB7: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CGB7 Gene

Orthologs for CGB7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGB7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CGB7 34 35
  • 99.6 (n)
cow
(Bos Taurus)
Mammalia LHB 35
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LHB 35
  • 64 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Lhb 35
  • 62 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia LHB 35
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 37 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii lhb 35
  • 39 (a)
OneToMany
Species where no ortholog for CGB7 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGB7 Gene

ENSEMBL:
Gene Tree for CGB7 (if available)
TreeFam:
Gene Tree for CGB7 (if available)

Paralogs for CGB7 Gene

Paralogs for CGB7 Gene

(8) SIMAP similar genes for CGB7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CGB7: view

Variants for CGB7 Gene

Sequence variations from dbSNP and Humsavar for CGB7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs111554568 -- 49,053,888(+) GTCTC(C/G)CTCCG downstream-variant-500B
rs111632238 -- 49,056,192(+) ACCGC(A/G)TAGTG upstream-variant-2KB, utr-variant-5-prime
rs111695299 -- 49,057,245(+) GATTA(G/T)AGCCT upstream-variant-2KB, utr-variant-5-prime
rs111775228 -- 49,055,410(+) GGCTT(C/T)ATACC utr-variant-5-prime
rs111869612 -- 49,057,540(+) GTTCT(A/G)CCCCC intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CGB7 Gene

Variant ID Type Subtype PubMed ID
dgv592n67 CNV loss 20364138
esv22462 CNV gain 19812545
esv2675899 CNV deletion 23128226
esv3644611 CNV loss 21293372
esv3644612 CNV gain 21293372
nsv520785 CNV gain 19592680
nsv833857 CNV loss 17160897
nsv833859 CNV loss 17160897
nsv953598 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495
nsv978832 CNV duplication 23825009

Variation tolerance for CGB7 Gene

Residual Variation Intolerance Score: 75% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.71; 78.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CGB7 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CGB7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGB7 Gene

Disorders for CGB7 Gene

MalaCards: The human disease database

(11) MalaCards diseases for CGB7 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
trisomy 22
  • chromosome 22 trisomy
choriocarcinoma
  • choriocarcinoma, no icd-o subtype
down syndrome
  • complete trisomy 21 syndrome
ectopic pregnancy
  • eccyesis
seminoma
  • seminoma, pure
- elite association - COSMIC cancer census association via MalaCards
Search CGB7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CGB7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CGB7
genes like me logo Genes that share disorders with CGB7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CGB7 Gene

Publications for CGB7 Gene

  1. Expression of beta-subunit of HCG genes during normal and failed pregnancy. (PMID: 16123088) Rull K. … Laan M. (Hum. Reprod. 2005) 4 22 64
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  3. Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection. (PMID: 11861891) Maston G.A. … Ruvolo M. (Mol. Biol. Evol. 2002) 3 22 64
  4. Malignant transformation of nontrophoblastic cells is associated with the expression of chorionic gonadotropin beta genes normally transcribed in trophoblastic cells. (PMID: 9012484) Bellet D. … Vidaud M. (Cancer Res. 1997) 3 22 64
  5. Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo. (PMID: 1371113) Bo M. … Boime I. (J. Biol. Chem. 1992) 3 22 64

Products for CGB7 Gene

Sources for CGB7 Gene

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