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Aliases for CGB7 Gene

Aliases for CGB7 Gene

  • Chorionic Gonadotropin, Beta Polypeptide 7 2 3
  • CGB6 3 6
  • Chorionic Gonadotropin Beta 7 Subunit 3
  • Chorionic Gonadotrophin Chain Beta 4
  • CGB CGB5 CGB7 CGB8 4
  • CG-Beta-A 3
  • CG-Beta 4
  • CGB3 4

External Ids for CGB7 Gene

Summaries for CGB7 Gene

Entrez Gene Summary for CGB7 Gene

  • This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 7 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CGB7 Gene

CGB7 (Chorionic Gonadotropin, Beta Polypeptide 7) is a Protein Coding gene. Diseases associated with CGB7 include gestational choriocarcinoma and nonseminomatous germ cell tumor. An important paralog of this gene is TSHB.

UniProtKB/Swiss-Prot for CGB7 Gene

  • Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

Gene Wiki entry for CGB7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGB7 Gene

Genomics for CGB7 Gene

Genomic Location for CGB7 Gene

Start:
49,054,274 bp from pter
End:
49,058,860 bp from pter
Size:
4,587 bases
Orientation:
Minus strand

Genomic View for CGB7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CGB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGB7 Gene

Regulatory Elements for CGB7 Gene

Proteins for CGB7 Gene

  • Protein details for CGB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01233-CGHB_HUMAN
    Recommended name:
    Choriogonadotropin subunit beta
    Protein Accession:
    P01233
    Secondary Accessions:
    • A1A5E0
    • B9ZVP5
    • Q13991
    • Q14000
    • Q3KPI3
    • Q3SY41
    • Q8WTT5
    • Q8WXL1
    • Q8WXL2
    • Q8WXL3
    • Q8WXL4

    Protein attributes for CGB7 Gene

    Size:
    165 amino acids
    Molecular mass:
    17739 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin
    SequenceCaution:
    • Sequence=CAA25068.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA25069.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CGB7 Gene

    Alternative splice isoforms for CGB7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CGB7 Gene

Proteomics data for CGB7 Gene at MOPED

Post-translational modifications for CGB7 Gene

  • Modification sites at PhosphoSitePlus
  • Glycosylation at Asn33, Asn50, Ser141, Ser147, Ser152, and Ser158

Other Protein References for CGB7 Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CGB7 Gene

Domains for CGB7 Gene

Graphical View of Domain Structure for InterPro Entry

P01233

UniProtKB/Swiss-Prot:

CGHB_HUMAN
Family:
  • Belongs to the glycoprotein hormones subunit beta family.:
    • P01233
genes like me logo Genes that share domains with CGB7: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CGB7 Gene

Function for CGB7 Gene

Molecular function for CGB7 Gene

UniProtKB/Swiss-Prot Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

Gene Ontology (GO) - Molecular Function for CGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity --
genes like me logo Genes that share ontologies with CGB7: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CGB7 Gene

Localization for CGB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGB7 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CGB7 Gene COMPARTMENTS Subcellular localization image for CGB7 gene
Compartment Confidence
extracellular 5
cytosol 4
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
genes like me logo Genes that share ontologies with CGB7: view

Pathways for CGB7 Gene

SuperPathways for CGB7 Gene

No Data Available

Interacting Proteins for CGB7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366493%0d%0a9606.ENSP00000358595%0d%0a
Selected Interacting proteins: P01233-CGHB_HUMAN ENSP00000366493 for CGB7 Gene via MINT I2D STRING

Gene Ontology (GO) - Biological Process for CGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process --
GO:0007165 signal transduction --
GO:0007267 cell-cell signaling --
GO:0007292 female gamete generation --
GO:0016486 peptide hormone processing --
genes like me logo Genes that share ontologies with CGB7: view

No data available for Pathways by source for CGB7 Gene

Compounds for CGB7 Gene

UniProtKB/Swiss-Prot:

P01233-CGHB_HUMAN
Pharmaceutical: Available under the names Novarel (Ferring) and Profasi (Serono). Used as adjunctive therapy in the treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting from caloric restriction, that it causes a more attractive or normal distribution of fat, or that it decreases the hunger and discomfort associated with calorie-restricted diets

(14) Novoseek inferred chemical compound relationships for CGB7 Gene

Compound -log(P) Hits PubMed IDs
oestriol 77 8
methotrexate 49.9 7
ctp 49.4 7
progesterone 34.9 10
etoposide 25 1
genes like me logo Genes that share compounds with CGB7: view

Transcripts for CGB7 Gene

Unigene Clusters for CGB7 Gene

Chorionic gonadotropin, beta polypeptide 7:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CGB7 Gene

No ASD Table

Relevant External Links for CGB7 Gene

GeneLoc Exon Structure for
CGB7
ECgene alternative splicing isoforms for
CGB7

Expression for CGB7 Gene

mRNA expression in normal human tissues for CGB7 Gene

mRNA differential expression in normal tissues according to GTEx for CGB7 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (6.9), Skin - Sun Exposed (Lower leg) (6.5), Prostate (4.5), and Esophagus - Mucosa (4.1).

SOURCE GeneReport for Unigene cluster for CGB7 Gene Hs.681647

mRNA Expression by UniProt/SwissProt for CGB7 Gene

P01233-CGHB_HUMAN
Tissue specificity: Placenta
genes like me logo Genes that share expressions with CGB7: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein expression for CGB7 Gene

Orthologs for CGB7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGB7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CGB7 35
  • 99.6 (n)
  • 100 (a)
CGB7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LHB 36
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LHB 36
  • 64 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Lhb 36
  • 62 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia LHB 36
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii lhb 36
  • 39 (a)
OneToMany
Species with no ortholog for CGB7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGB7 Gene

ENSEMBL:
Gene Tree for CGB7 (if available)
TreeFam:
Gene Tree for CGB7 (if available)

Paralogs for CGB7 Gene

Paralogs for CGB7 Gene

Selected SIMAP similar genes for CGB7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CGB7: view

Variants for CGB7 Gene

Sequence variations from dbSNP and Humsavar for CGB7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3810178 -- 49,055,843(+) GAGGG(C/T)CTCCC upstream-variant-2KB, utr-variant-5-prime, intron-variant
rs3810179 -- 49,056,072(+) ACATT(A/G)TCTGG upstream-variant-2KB, utr-variant-5-prime, intron-variant
rs3810180 -- 49,056,261(+) TGGCC(C/G)GGCAG upstream-variant-2KB, utr-variant-5-prime, intron-variant
rs3810181 -- 49,056,860(+) ACCGA(A/C/T)GGAGG upstream-variant-2KB, intron-variant
rs3810182 -- 49,057,204(+) GTGAA(A/G)GGTGG upstream-variant-2KB, utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CGB7 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833857 CNV Loss 17160897
nsv912248 CNV Loss 21882294
dgv3970n71 CNV Loss 21882294
nsv833859 CNV Loss 17160897
nsv912251 CNV Loss 21882294
esv22462 CNV Gain 19812545
nsv912252 CNV Loss 21882294
dgv592n67 CNV Loss 20364138
esv2675899 CNV Deletion 23128226
nsv520785 CNV Gain 19592680

Relevant External Links for CGB7 Gene

HapMap Linkage Disequilibrium report
CGB7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGB7 Gene

Disorders for CGB7 Gene

(1) University of Copenhagen DISEASES for CGB7 Gene

(32) Novoseek inferred disease relationships for CGB7 Gene

Disease -log(P) Hits PubMed IDs
down syndrome 87.7 50
choriocarcinoma 73.4 6
pregnancy ectopic 69.5 12
trisomy 66.6 15
pregnancy tubal 59.4 3
genes like me logo Genes that share disorders with CGB7: view

No data available for UniProtKB/Swiss-Prot for CGB7 Gene

Publications for CGB7 Gene

  1. Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection. (PMID: 11861891) Maston G.A. … Ruvolo M. (Mol. Biol. Evol. 2002) 3 4 23
  2. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PMID: 6194155) Policastro P. … Boime I. (J. Biol. Chem. 1983) 2 3 4
  3. The amino acid sequence of human chorionic gonadotropin. The alpha subunit and beta subunit. (PMID: 1150658) Morgan F.J. … Canfield R.E. (J. Biol. Chem. 1975) 3 4
  4. Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form. (PMID: 1688430) Saccuzo Beebe J. … Ruddon R.W. (J. Biol. Chem. 1990) 3 4
  5. Site-specific N-glycosylation of human chorionic gonadotrophin -- structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy. (PMID: 1820200) Weisshaar G. … Renwick A.G.C. (Glycobiology 1991) 3 4

Products for CGB7 Gene

Sources for CGB7 Gene

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