Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CGB7 Gene

Aliases for CGB7 Gene

  • Chorionic Gonadotropin, Beta Polypeptide 7 2 3
  • Chorionic Gonadotropin Beta 7 Subunit 3
  • Chorionic Gonadotrophin Chain Beta 4
  • CGB CGB5 CGB7 CGB8 4
  • CG-Beta-A 3
  • CG-Beta 4
  • CGB3 4
  • CGB6 3

External Ids for CGB7 Gene

Previous GeneCards Identifiers for CGB7 Gene

  • GC19M050215
  • GC19M049920
  • GC19M054233
  • GC19M054242
  • GC19M054249
  • GC19M049557
  • GC19M045934

Summaries for CGB7 Gene

Entrez Gene Summary for CGB7 Gene

  • This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 7 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CGB7 Gene

CGB7 (Chorionic Gonadotropin, Beta Polypeptide 7) is a Protein Coding gene. Diseases associated with CGB7 include trisomy 22 and nonseminomatous germ cell tumor. Among its related pathways are Transport to the Golgi and subsequent modification and Peptide hormone metabolism. GO annotations related to this gene include hormone activity. An important paralog of this gene is TSHB.

UniProtKB/Swiss-Prot for CGB7 Gene

  • Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

Gene Wiki entry for CGB7 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGB7 Gene

Genomics for CGB7 Gene

Regulatory Elements for CGB7 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CGB7 Gene

Chromosome:
19
Start:
49,054,274 bp from pter
End:
49,058,860 bp from pter
Size:
4,587 bases
Orientation:
Minus strand

Genomic View for CGB7 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CGB7 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGB7 Gene

Proteins for CGB7 Gene

  • Protein details for CGB7 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01233-CGHB_HUMAN
    Recommended name:
    Choriogonadotropin subunit beta
    Protein Accession:
    P01233
    Secondary Accessions:
    • A1A5E0
    • B9ZVP5
    • Q13991
    • Q14000
    • Q3KPI3
    • Q3SY41
    • Q8WTT5
    • Q8WXL1
    • Q8WXL2
    • Q8WXL3
    • Q8WXL4

    Protein attributes for CGB7 Gene

    Size:
    165 amino acids
    Molecular mass:
    17739 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin
    SequenceCaution:
    • Sequence=CAA25068.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA25069.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CGB7 Gene

    Alternative splice isoforms for CGB7 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CGB7 Gene

Proteomics data for CGB7 Gene at MOPED

Post-translational modifications for CGB7 Gene

  • Glycosylation at Asn 33, Asn 50, Ser 141, Ser 147, Ser 152, and Ser 158
  • Modification sites at PhosphoSitePlus

Other Protein References for CGB7 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CGB7 Gene

Domains & Families for CGB7 Gene

Graphical View of Domain Structure for InterPro Entry

P01233

UniProtKB/Swiss-Prot:

CGHB_HUMAN :
  • Belongs to the glycoprotein hormones subunit beta family.
Family:
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with CGB7: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CGB7 Gene

Function for CGB7 Gene

Molecular function for CGB7 Gene

UniProtKB/Swiss-Prot Function:
Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

Gene Ontology (GO) - Molecular Function for CGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity --
genes like me logo Genes that share ontologies with CGB7: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CGB7

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CGB7 Gene

Localization for CGB7 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGB7 Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CGB7 Gene COMPARTMENTS Subcellular localization image for CGB7 gene
Compartment Confidence
extracellular 5
cytosol 2
golgi apparatus 2
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region --
genes like me logo Genes that share ontologies with CGB7: view

Pathways & Interactions for CGB7 Gene

genes like me logo Genes that share pathways with CGB7: view

Pathways by source for CGB7 Gene

Interacting Proteins for CGB7 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000366493%0d%0a9606.ENSP00000358595%0d%0a
Selected Interacting proteins: P01233-CGHB_HUMAN ENSP00000366493 for CGB7 Gene via MINT I2D STRING

Gene Ontology (GO) - Biological Process for CGB7 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process --
GO:0007165 signal transduction --
GO:0007267 cell-cell signaling --
GO:0007292 female gamete generation --
GO:0016486 peptide hormone processing --
genes like me logo Genes that share ontologies with CGB7: view

No data available for SIGNOR curated interactions for CGB7 Gene

Drugs & Compounds for CGB7 Gene

(10) Drugs for CGB7 Gene - From: NovoSeek and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bleomycin Approved Pharma 142
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Estradiol Approved, Investigational Pharma Sex hormone 1057
Etoposide Approved Pharma Topo II inhibitor, Topoisomerase 2 Inhibitors, Topoisomerase II inhibitor 1127
Levothyroxine Approved Pharma 0

(5) Additional Compounds for CGB7 Gene - From: NovoSeek

genes like me logo Genes that share compounds with CGB7: view

Transcripts for CGB7 Gene

Unigene Clusters for CGB7 Gene

Chorionic gonadotropin, beta polypeptide 7:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CGB7

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CGB7 Gene

No ASD Table

Relevant External Links for CGB7 Gene

GeneLoc Exon Structure for
CGB7
ECgene alternative splicing isoforms for
CGB7

Expression for CGB7 Gene

mRNA expression in normal human tissues for CGB7 Gene

mRNA differential expression in normal tissues according to GTEx for CGB7 Gene

This gene is overexpressed in Skin - Not Sun Exposed (Suprapubic) (x6.9), Skin - Sun Exposed (Lower leg) (x6.5), Prostate (x4.5), and Esophagus - Mucosa (x4.1).

SOURCE GeneReport for Unigene cluster for CGB7 Gene Hs.681647

mRNA Expression by UniProt/SwissProt for CGB7 Gene

P01233-CGHB_HUMAN
Tissue specificity: Placenta
genes like me logo Genes that share expression patterns with CGB7: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CGB7 Gene

Orthologs for CGB7 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGB7 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CGB7 35
  • 99.6 (n)
  • 100 (a)
CGB7 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia LHB 36
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LHB 36
  • 64 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia LHB 36
  • 55 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Lhb 36
  • 62 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii lhb 36
  • 39 (a)
OneToMany
Species with no ortholog for CGB7:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGB7 Gene

ENSEMBL:
Gene Tree for CGB7 (if available)
TreeFam:
Gene Tree for CGB7 (if available)

Paralogs for CGB7 Gene

Paralogs for CGB7 Gene

(8) SIMAP similar genes for CGB7 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CGB7: view

Variants for CGB7 Gene

Sequence variations from dbSNP and Humsavar for CGB7 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs3810178 -- 49,055,843(+) GAGGG(C/T)CTCCC upstream-variant-2KB, utr-variant-5-prime
rs3810179 -- 49,056,072(+) ACATT(A/G)TCTGG upstream-variant-2KB, utr-variant-5-prime
rs8108817 -- 49,054,266(+) GACAC(C/G/T)GCCAG downstream-variant-500B
rs12461085 -- 49,055,472(+) GAGCT(C/G)GACAC utr-variant-5-prime
rs12461088 -- 49,055,522(+) GCACA(C/G)GAGTG utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CGB7 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833857 CNV Loss 17160897
nsv912248 CNV Loss 21882294
dgv3970n71 CNV Loss 21882294
nsv833859 CNV Loss 17160897
nsv912251 CNV Loss 21882294
esv22462 CNV Gain 19812545
nsv912252 CNV Loss 21882294
dgv592n67 CNV Loss 20364138
esv2675899 CNV Deletion 23128226
nsv520785 CNV Gain 19592680

Variation tolerance for CGB7 Gene

Residual Variation Intolerance Score: 75.04% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.71; 78.66% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CGB7 Gene

HapMap Linkage Disequilibrium report
CGB7

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGB7 Gene

Disorders for CGB7 Gene

MalaCards: The human disease database

(12) MalaCards diseases for CGB7 Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
trisomy 22
  • chromosome 22 trisomy
nonseminomatous germ cell tumor
  • non-seminomatous germ-cell tumors
sacrococcygeal teratoma
triploidy
  • chromosome triploidy syndrome
testicular teratoma
  • teratoma of the testis
- elite association
Search CGB7 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CGB7

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CGB7
genes like me logo Genes that share disorders with CGB7: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CGB7 Gene

Publications for CGB7 Gene

  1. Glial cells missing homologue 1 is induced in differentiating equine chorionic girdle trophoblast cells. (PMID: 18971425) de Mestre A.M. … Antczak D.F. (Biol. Reprod. 2009) 23 67
  2. Performance of free beta-human chorionic gonadotrophin (free beta-hCG) and pregnancy associated plasma protein-A (PAPP-A) analysis between Delfia Xpress and AutoDelfia systems in The Netherlands. (PMID: 19191730) Linskens I.H. … Dijstelbloem H.M. (Clin. Chem. Lab. Med. 2009) 23 67
  3. Influence of serum from pregnant women and selected pregnancy hormones on in-vitro maturation of murine oocytes. (PMID: 18492371) Lin Y.H. … Tzeng C.R. (Reprod. Biomed. Online 2008) 23 67
  4. Alpha-fetoprotein and human chorionic gonadotrophin-beta as prognostic markers in neuroendocrine tumour patients. (PMID: 18577995) Shah T. … Caplin M.E. (Br. J. Cancer 2008) 23 67
  5. Is screening for fetal anomalies reliable in HIV-infected pregnant women? A multicentre study. (PMID: 18784463) Brossard P. … . (AIDS 2008) 23 67

Products for CGB7 Gene

Sources for CGB7 Gene

Back to Top

Content