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CGB5 Gene

protein-coding   GIFtS: 53

GC19P054238
chorionic gonadotropin, beta polypeptide 5
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
Services    
(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc , and/or 7Ensembl, 8miRBase)
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Aliases
CG-beta 3
CGB3 3
HCG 1, 2
MGC119822 2
Descriptions
Chorionic gonadotrophin chain beta 3
chorionic gonadotropin beta 5 subunit 2
chorionic gonadotropin, beta polypeptide 5 2
External Ids
HGNC: 164521
Entrez Gene: 936592
UniProtKB: P012333
Ensembl: ENSG000001890527
Search outside databases for aliases for CGB5 gene

Previous GC identifers: GC19P050194 GC19P049915 GC19P054223 GC19P054227

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CGB5:
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit
of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common
alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by
the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that
are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which
are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the
luteinizing hormone beta subunit gene. [provided by RefSeq]

UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance
of pregnancy

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:
UCSC Golden Path with GeneCards custom track

 Transcription factor binding sites upstream to the CGB5 gene  

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.32

CGB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P054238:     (about GC identifiers)

Start:
54,238,875 bp from pter
End:
54,240,380 bp from pter
Size:
1,506 bases
Orientation:
plus strand
RefSeq DNA sequence:
NC_000019.8  NT_011109.15  
(According to 1UniProtKB, and/or Ensembl, Phosphorylation sites according to 2Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
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UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233 (See protein sequence)
Recommended Name: Choriogonadotropin subunit beta precursor  
Size: 165 amino acids; 17739 Da
Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological
specificity to thyrotropin, lutropin, follitropin and gonadotropin
Subcellular location: Secreted
Developmental stage: Made by the first trimester placenta
PDB structures from and Proteopedia :
1HCN (3D)    1HRP (3D)    1QFW (3D)    1XUL (3D)    
Secondary accessions: Q13991 Q14000 Q3KPI3 Q3SY41 Q8WTT5 Q8WXL1 Q8WXL2 Q8WXL3 Q8WXL4

Post-translational modifications:

  • View phosphorylation sites using PhosphoSite2


  • REFSEQ proteins: NP_149032.1  

    ENSEMBL proteins: 
    ENSP00000301408 


    Human Recombinant Proteins 
    Browse Drug Discovery Central at Invitrogen for human recombinant proteins
    Browse Purified and Recombinant Proteins at Millipore
    Sigma-Aldrich Proteins for CGB5  
    Browse R&D Systems for human recombinant proteins
    Browse recombinant and purified proteins available from Enzo Life Sciences
    Recombinant Proteins from Abcam (CGB5)
    Human Recombinant Proteins from Abnova (CGB5)
                    Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 


    Antibodies for CGB5: 
    Browse Antibodies Central at Invitrogen
    Millipore Mono- and Polyclonal Antibodies for the study of CGB5
    Sigma-Aldrich Antibodies for CGB5
    Browse R&D Systems for Antibodies
    Antibodies from Abcam (CGB5), each with their AbpromiseSM
    Monoclonal and Polyclonal Antibodies from Abnova (CGB5)
    Novus Biologicals Antibodies for CGB5

    Assays for CGB5: 
    Browse Invitrogen for biochemical assays
    Browse Kits and Assays available from Millipore
    Browse R&D Systems for biochemical assays
    Browse biochemical assays available from Enzo Life Sciences

    (According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section

    3 InterPro domains/families:
     IPR018245 Gonadotropin_bsu_CS
     IPR001545 Gonadotropin_bsu
     IPR006208 Cys_knot


       GeneDecks  CGB5 for the domains selected above  
    About GeneDecksing

    Graphical View of Domain Structure for InterPro Entry P01233

    ProtoNet protein and cluster: P01233

    3 Blocks protein families:
    IPB001545 Gonadotropin
    IPB002400 Growth factor cystine knot superfamily signature
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Similarity: Belongs to the glycoprotein hormones subunit beta family

    (According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
    shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
    RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section

    Inhib.
    RNA:
    Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (CGB5)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_033043

                  Applied Biosystems Silencer® siRNAs for CGB5

                  Browse siRNA at Sigma-Aldrich  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Clones:Invitrogen Clones for CGB5
    Browse Clones for the Expression of Recombinant Proteins Available from Millipore
                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_033043
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_033043
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_033043 

    Primers: Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers
                  OriGene genome-wide validated SYBR primer pairs: NM_033043

    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance
    of pregnancy

    (Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
    Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to 1UniProtKB, 2MINT, and/or 3STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
    About This Section



    5/9 Interacting proteins for CGB5 (ENSP000003014083 P012332) via UniProtKB, MINT, and/or STRING (see all 9 )
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CGAP012152STRING (score=.999) MINT-24926
    GNRHRENSP000002264133STRING (score=.925)
    ETS2ENSP000003533443STRING (score=.887)
    LHCGRENSP000002949543STRING (score=.837)
    FSHRENSP000003067803STRING (score=.827)
    About this table
    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
    About This Section

    Browse drugs & compounds from Enzo Life Sciences
    Browse Small Molecules at Sigma-Aldrich

    Browse Tocris compounds for CGB5
    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Pharmaceutical: Available under the names Novarel (Ferring) and Profasi (Serono). Used as
    adjunctive therapy in the treatment of obesity. There is no substantial evidence that it increases
    weight loss beyond that resulting from caloric restriction, that it causes a more attractive or
    'normal' distribution of fat, or that it decreases the hunger and discomfort associated with
    calorie-restricted diets

    10/51 Novoseek chemical compound relationships for CGB5 gene (see all 51 )
    Compound   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 79.30 475 18070493 (6), 7629236 (6), 8147233 (5), 11750960 (5) (see all 99)
    estradiol 70.01 132 18413150 (4), 19191722 (4), 2117066 (3), 1479151 (3) (see all 74)
    b 152 66.32 6 17092638 (3)
    3beta-hydroxysteroid 58.77 6 2149342 (1), 8187962 (1), 8964869 (1), 11384877 (1) (see all 6)
    17-hydroxyprogesterone 58.69 14 9593605 (3), 1577246 (2), 9363253 (1), 10599984 (1) (see all 9)
    22r-hydroxycholesterol 57.71 6 17431488 (1), 19330017 (1), 7556884 (1), 10613393 (1)
    steroid 56.69 50 7629236 (3), 10936036 (2), 7531411 (2), 18336931 (2) (see all 36)
    11-ketotestosterone 55.15 20 12714013 (2), 9771643 (2), 15965976 (2), 9493828 (1) (see all 7)
    androstenedione 54.68 20 10600792 (3), 11870113 (2), 10685528 (2), 2158194 (1) (see all 15)
    percoll 49.52 8 2170316 (2), 1847300 (1), 2318939 (1), 1612524 (1) (see all 6)
    About this table


    (GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView,
    non coding RNAs according to RNAdb,
    ESTs according to GeneTide,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from Invitrogen, Millipore, and/or Abnova,
    siRNAs from Applied Biosystems, Sigma-Aldrich,
    shRNA from Sigma-Aldrich, OriGene,
    Tagged/untagged cDNA clones from OriGene)
    About This Section

    Inhib.
    RNA:
    Browse Invitrogen for RNAi
    Browse for Gene Knock-down Tools from Millipore
    Abnova Chimera RNAi Products for Gene knock-down (CGB5)
                  OriGene 29mer shRNA kit in GFP-retroviral vector: NM_033043

                  Browse siRNA at Sigma-Aldrich  
                         Browse shRNA at Sigma-Aldrich  
                         Explore Sigma-Aldrich super-pooled esiRNAs  

    Applied Biosystems Silencer® siRNAs: 

    NM_033043  

    REFSEQ mRNAs for CGB5 gene: 

    NM_033043.1   


                  OriGene GFP tagged cDNA clone in CMV expression vector: NM_033043
                                     Myc/DDK tagged cDNA clone in CMV expression vector: NM_033043
                                     untagged cDNA clones in CMV expression vector (see all 2): NM_033043 

    Additional cDNA sequence: 

    BC006290.2 BC051378.1 BC103970.1 BC103971.1 BC106723.1 BC106724.1 BT006890.1 K03180.1 

    5 DOTS entries:

    DT.119691  DT.100837633  DT.97797965  DT.92436853  DT.95315378 

    24/247 AceView cDNA sequences (see all 247 ):

    CA944648 BC069367 NM_033378 AA330859 BC051378 AA331012 BC006290 NM_033043 
    T50278 BU752275 BQ011219 AA330803 BE732062 CF527786 BG434117 AU139360 
    AI189842 BV195545 AI149559 BV199139 N40038 BE733206 BQ011244 AI871881 

    highest scoring ESTs for CGB5:

    CB998315 BT006890 BC051378 CB993686 AI868741 BE733206 BE903261 BG434117 BQ004107 BQ007333 

    Unigene Cluster for CGB5:

    Chorionic gonadotropin, beta polypeptide 5
    Hs.590955  [show with all ESTs]
    Unigene Representative Sequence: BM916725


    GeneLoc Exon Structure

    1 Ensembl transcript including schematic representation:
    ENST00000301408  
    (Experimental results according to 1GeneNote and GNF BioGPS,
    probe sets-to-genes annotations according to 2GeneAnnot , 3GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
    Expression Assays from Applied Biosystems )
    About This Section

    CGB5 expression in normal and diseased human tissues

    1 / 2 / 3

    5 probe-sets matching CGB5 gene


    Affymetrix
    probe-set
    Array  GeneAnnot data GeneNote data GeneTide data
    # genes Sensitivity Specificity Correlation Length Gb_Accession Consensus Uniqueness Score Rank

    1152_i_at2, 3 U95-A 4 1.00 0.25 0.64 0.46 J00117 0.40 0.07 0.29 4
    1153_f_at2, 3 U95-A 7 1.00 0.16 0.53 1.09 J00117 0.40 0.07 0.29 4

    1122_f_at2, 3 U95-A 7 0.88 0.15 0.68 1.50 K03183 0.20 0.25 0.23 1

    205387_s_at2 U133-A 7 1.00 0.20 -- -- -- -- -- -- --

    205387_s_at2 U133Plus2 7 1.00 0.20 -- -- -- -- -- -- --
    GeneDecks  CGB5 for binary patterns associated with the probe-sets selected above  
    About GeneDecksing
    About this table    
    Data from (Publications) and GNF BioGPS
        About these images
    About these images

    CGAP SAGE TAG: --

    SOURCE GeneReport for Unigene cluster: Hs.590955

    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Tissue specificity: Placenta

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD and/or 5MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
    About This Section


    Orthologs for CGB5 gene from 1 species
    Organism Gene Locus Description Human
    Similarity
    NCBI accessions
    chimpanzee
    (Pan troglodytes)
    CGB1   -- chorionic gonadotropin, beta polypeptide 99.19(n)
    98.18(a)
    747776  XM_001172080.1  XP_001172080.1 
    About this table        Species with no ortholog for CGB5

    ENSEMBL Gene Tree for CGB5
    (Paralogs according to 1HomoloGene
    and 2Ensembl, Pseudogenes according to 3Pseudogene.org)
    About This Section

    Paralogs for CGB5 gene
    CGB81 2  CGB1 2  TSHB2  CGB22  FSHB2  LHB2  GPHB52  CGB72  
    CGB12  

    (According to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
    About This Section


    10/44 NCBI SNPs in CGB5 are shown (see all 44 )
    ABGenomic DataTranscription DataAllele Frequencies
    SNP IDValidChr 19 posSequenceRecsAA
    Chg
    TypeMoreRecsAllele
    freq
    PopTotal
    sample
    More
    ------------
    --
    rs72600021,2
    A,C,F,H54237684(+) AGGCCA/CAGCAG 1 -- ng518Minor allele frequency- C:0.23EU EA WA 836
    --
    rs339143431,2
    C,F54238951(+) TGGCTA/C/G/
            
    CCAGG
    1 -- ut519EU WA EA 570
    --
    rs104265551,2
    A,C54237637(+) GGGCTA/GCCGCA 1 -- ng510--------
    --
    rs72460451,2
    A,C54237894(+) CAGTTG/TGGGAA 1 -- ng510--------
    --
    rs104221281,2
    C,F54240661(+) caggtA/Tcttgg 1 -- ng311Minor allele frequency- T:0.18EU 22
    --
    rs351824021,2
    F54240492(+) ACAGGG/ATGGAC 1 -- ng313Minor allele frequency- A:0.01EU WA EA 190
    --
    rs129861531,2
    C54238082(+) TAGCCA/CTAATA 1 -- ng510--------
    --
    rs118815151,2
    C54238688(+) GCTCCA/GGGCAT 1 -- ng510--------
    --
    rs104197391,2
    C54237038(+) GGCTTC/TCCCAT 1 -- ng510--------
    --
    rs356968541,2
    F54240387(+) TCTGGA/CGGTGT 1 -- ng313Minor allele frequency- C:0.04EU WA EA 190
    About this table

    HapMap Linkage Disequilibrium images for CGB5 (up to first 250kb)

    (in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
    About This Section

    OMIM: 608825

    10/91 Novoseek disease relationships for CGB5 gene (see all 91 )

    Disease   Score   Articles   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 92.07 211 9833611 (5), 1889509 (4), 9826481 (4), 1967025 (4) (see all 99)
    trophoblastic disease 90.42 68 1710641 (3), 9833612 (3), 8035374 (3), 15346663 (3) (see all 37)
    hydatidiform mole 90.11 102 17462723 (6), 19155902 (4), 16711513 (3), 1679110 (2) (see all 50)
    gestational trophoblastic disease 89.04 76 9475142 (3), 15663134 (3), 17086808 (3), 15305826 (3) (see all 39)
    trophoblastic tumor 89.03 18 7712876 (2), 2167776 (2), 1661266 (1), 8492514 (1) (see all 15)
    trophoblastic tumor placental site 87.59 14 11972394 (1), 12748494 (1), 17701427 (1), 17086809 (1) (see all 7)
    gestational trophoblastic tumor 81.90 7 19004403 (1), 12681878 (1), 18762963 (1), 7970479 (1) (see all 5)
    pregnancy ectopic 81.66 85 16507931 (7), 7614131 (4), 14633876 (4), 16308901 (4) (see all 54)
    ovarian hyperstimulation syndrome 75.28 10 8005301 (1), 7920947 (1), 9240261 (1), 14976788 (1) (see all 7)
    hydatidiform mole invasive 72.53 2 19099349 (1)
    About this table

    Genetic Association Database: CGB5
    Human Genome Epidemiology Navigator: CGB5 (2 documents)

    (Possibly Related Articles in Doctor's Guide)
    About This Section

      --

    (in PubMed. Associations of this gene to articles via 1Novoseek, 2HGNC, 3Entrez Gene, 4UniProtKB/Swiss-Prot, 5UniProtKB/TrEMBL, 6GAD, and/or 7PharmGKB)
    About This Section

    10/972 PubMed articles for CGB5 gene (see all 972 ):
    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section

     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)
    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
    About This Section

    Entrez Gene: 93659 HGNC: 16452 AceView: CGB5andCGB2 Ensembl:ENSG00000189052 euGenes: HUgn93659
    ECgene: CGB5 H-InvDB: CGB5
    (According to HUGE)
    About This Section

      --
    (According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section

    NameDescription
    Wikipedia http://en.wikipedia.org/wiki/Human_chorionic_gonadotropin
    (Available from WIS Yeda, Salk, Tufts)
    About This Section

      --
    (Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
    Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
    Enzo Life Sciences, and/or Tocris Bioscience)
    About This Section



    Products for CGB5:
      Free SNP selection tool



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     Antibodies for CGB5

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