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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CGB5 Gene

protein-coding   GIFtS: 51
GCID: GC19P049547

Chorionic Gonadotropin, Beta Polypeptide 5

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chorionic Gonadotropin, Beta Polypeptide 51 2
HCG2
Chorionic Gonadotropin Beta 5 Subunit2
CG-beta3
CGB33
Chorionic Gonadotrophin Chain Beta3

External Ids:    HGNC: 164521   Entrez Gene: 936592   Ensembl: ENSG000001890527   OMIM: 6088255   UniProtKB: P012333   

Export aliases for CGB5 gene to outside databases

Previous GC identifers: GC19P050194 GC19P049915 GC19P054223 GC19P054227 GC19P054238 GC19P045923


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CGB5 Gene:
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic
gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta
subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and
stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta
subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and
contiguous with the luteinizing hormone beta subunit gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CGB5 Gene: 
CGB5 (chorionic gonadotropin, beta polypeptide 5) is a protein-coding gene. Diseases associated with CGB5 include malignant sertoli cell tumor, and corpus luteum cyst. An important paralog of this gene is TSHB.

UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CGB5 gene promoter:
         NF-1   NF-1/L   Pax-5   POU3F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCGB5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CGB5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CGB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.32

CGB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CGB5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P049547:  view genomic region     (about GC identifiers)

Start:
49,547,102 bp from pter      End:
49,548,568 bp from pter
Size:
1,467 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233 (See protein sequence)
Recommended Name: Choriogonadotropin subunit beta precursor  
Size: 165 amino acids; 17739 Da
Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to
thyrotropin, lutropin, follitropin and gonadotropin
Subcellular location: Secreted
Developmental stage: Made by the first trimester placenta
Sequence caution: Sequence=CAA25068.1; Type=Erroneous initiation; Sequence=CAA25069.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for CGB5:
1HCN (3D)        1HRP (3D)        1QFW (3D)        1XUL (3D)    
Secondary accessions: A1A5E0 B9ZVP5 Q13991 Q14000 Q3KPI3 Q3SY41 Q8WTT5 Q8WXL1 Q8WXL2 Q8WXL3
Q8WXL4
Alternative splicing: 2 isoforms:  P01233-1   P01233-2   (Ref.2 (CAA25069) sequence is in conflict in positions: 7:G->R, 9:A->V, 12:D->G)

Explore the universe of human proteins at neXtProt for CGB5: NX_P01233

Explore proteomics data for CGB5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P01233

  • CGB5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CGB5 Protein Expression
    REFSEQ proteins: NP_149032.1  
    ENSEMBL proteins: 
     ENSP00000301408  
    Reactome Protein details: P01233
    Human Recombinant Protein Products for CGB5: 
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    Novus Biologicals CGB5 Proteins
    Novus Biologicals CGB5 Lysate
    Sino Biological Recombinant Protein for CGB5
    Sino Biological Cell Lysate for CGB5 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----

    CGB5 for ontologies           About GeneDecksing



    CGB5 Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    3 InterPro protein domains:
     IPR018245 Gonadotropin_bsu_CS
     IPR001545 Gonadotropin_bsu
     IPR006208 Cys_knot

    Graphical View of Domain Structure for InterPro Entry P01233

    ProtoNet protein and cluster: P01233

    3 Blocks protein domains:
    IPB001545 Gonadotropin
    IPB002400 Growth factor cystine knot superfamily signature
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Similarity: Belongs to the glycoprotein hormones subunit beta family


    CGB5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CGHB_HUMAN, P01233
    Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity ----
         
    CGB5 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CGB5 
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGB5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    Pathways by sourceSee SuperPaths
    Show all pathways



    4        Reactome Pathways for CGB5
        Peptide hormone biosynthesis
    Metabolism of proteins
    Glycoprotein hormones
    Peptide hormone metabolism



    CGB5 for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CGB5

    STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

    5 Interacting proteins for CGB5 (P012332, 3 ENSP000003014084) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CGAP012152, 3, ENSP000003585954MINT-24926 I2D: score=5 STRING: ENSP00000358595
    CKBP122773I2D: score=1 
    EWSR1Q018443I2D: score=1 
    FSHBP012253I2D: score=1 
    LHCGRP228883I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process ----
    GO:0007165signal transduction ----
    GO:0007267cell-cell signaling ----
    GO:0007292female gamete generation ----
    GO:0016486peptide hormone processing ----

    CGB5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CGB5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CGB5 (CGHB)

    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Pharmaceutical: Available under the names Novarel (Ferring) and Profasi (Serono). Used as adjunctive therapy in
    the treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting
    from caloric restriction, that it causes a more attractive or 'normal' distribution of fat, or that it decreases
    the hunger and discomfort associated with calorie-restricted diets

    10/140 Novoseek inferred chemical compound relationships for CGB5 gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 79.4 499 18070493 (6), 20503230 (6), 7629236 (6), 8147233 (5) (see all 99)
    testosterone 73.2 344 7629236 (6), 17477304 (5), 12220777 (5), 12538621 (4) (see all 99)
    gnrh 72.2 267 7852524 (10), 8114013 (7), 7951519 (6), 1517367 (6) (see all 84)
    estradiol 69.8 139 18413150 (4), 19191722 (4), 2117066 (3), 1479151 (3) (see all 78)
    b 152 65.9 6 17092638 (3)
    methotrexate 61.7 82 16313819 (4), 11919242 (4), 17173905 (4), 9302177 (4) (see all 36)
    3beta-hydroxysteroid 60.1 7 19501915 (1), 2149342 (1), 8187962 (1), 8964869 (1) (see all 7)
    11-ketotestosterone 58.6 23 12714013 (2), 9771643 (2), 15965976 (2), 9493828 (1) (see all 9)
    17-hydroxyprogesterone 57.6 14 9593605 (3), 1577246 (2), 9363253 (1), 10599984 (1) (see all 9)
    22r-hydroxycholesterol 57 6 17431488 (1), 19330017 (1), 7556884 (1), 10613393 (1)

    Search CenterWatch for drugs/clinical trials and news about CGB5 / CGHB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CGB5 gene: 
    NM_033043.1  

    Unigene Cluster for CGB5:

    Chorionic gonadotropin, beta polypeptide 5
    Hs.172944  [show with all ESTs]
    Unigene Representative Sequence: BM916725
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000301408(uc002ply.3)
    miRNA
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    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CGB5
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    GenScript: all cDNA clones in your preferred vector: CGB5 (NM_033043)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CGB5
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    OriGene qPCR primer pairs and template standards for CGB5
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CGB5
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    Additional mRNA sequence: 

    BC006290.2 BC051378.1 BC103970.1 BC103971.1 BC106723.1 BC106724.1 BT006890.1 K03180.1 

    5 DOTS entries:

    DT.119691  DT.97797965  DT.100837633  DT.92436853  DT.95315378 

    24/247 AceView cDNA sequences (see all 247):

    BC069367 NM_033378 NM_033043 BC051378 AA331012 T50278 BC006290 CA944648 
    AA330859 BU752320 BT006890 CF528171 AI871881 BU752315 BQ011275 AI168482 
    BX439414 BQ003981 BQ004041 BX339535 BQ007392 AA330413 NM_033183 BQ003996 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CGB5 expression in normal human tissues (normalized intensities)      CGB5 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CGB5 Expression
    About this image


    CGB5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/3 selected tissues (see all 3) fully expand
     
     Neuron (Nervous System)
             GABA neuron-like cells ( Generation of motor and gamma-aminobutyric acid (GABA)...
     
     Brain (Nervous System)
             GABA neuron-like cells ( Generation of motor and gamma-aminobutyric acid (GABA)...
     
     Placenta (Extraembryonic Tissues)

    See CGB5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CGB5

    SOURCE GeneReport for Unigene cluster: Hs.172944

    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Tissue specificity: Placenta

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    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGB5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CGB5 gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    37(a)
    1 → many
    6(80158039-80158659)
    zebrafish
    (Danio rerio)
    Actinopterygii lhb6
    luteinizing hormone, beta polypeptide
    39(a)
    1 → many
    Zv9_scaffold3525(54871-57837)
    fruit fly
    (Drosophila melanogaster)
    Insecta Gpb56
    Glycoprotein hormone beta 5
    13(a)
    1 → many
    2LHet(167215-167979)
            Species with no ortholog for CGB5

    ENSEMBL Gene Tree for CGB5 (if available)
    TreeFam Gene Tree for CGB5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CGB5 gene
    CGB81 2  CGB1 2  TSHB2  FSHB2  CGB22  LHB2  ENSG000002673352  CGB72  
    CGB12  
    7 SIMAP similar genes for CGB5 using alignment to 1 protein entry:     CGHB_HUMAN:
    CGB8    CGB1    CGB2    CGB7    LHB    FSHB
    TSHB

    CGB5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/156 SNPs in CGB5 are shown (see all 156)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829806811,2
    --49545169(+) ACAAGA/TTGGGT 1 -- us2k10--------
    rs1131773791,2
    C,F--49545179(+) TGTTAC/TGCAAG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs104197391,2
    C,F--49545226(+) GGCTTT/CCCCAT 1 -- us2k15Minor allele frequency- C:0.40NA WA 10
    rs1405126441,2
    --49545262(+) GGGTTC/TCCAAC 1 -- us2k10--------
    rs1458935001,2
    --49545327(+) TGTCTC/TCATGT 1 -- us2k10--------
    rs2013464381,2
    --49545334(+) ATGTG-/CTCTGAG 1 -- us2k10--------
    rs1876114121,2
    --49545370(+) TCCCCC/TAGACT 1 -- us2k10--------
    rs1917760411,2
    --49545382(+) CCTCTA/GCATCC 1 -- us2k10--------
    rs1413406061,2
    --49545441(+) CTCGAA/CATTGT 1 -- us2k10--------
    rs1843200651,2
    --49545457(+) TTTCCC/TGATCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CGB5 (49547102 - 49548568 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CGB5:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2718698CNV Deletion23290073
    nsv833859CNV Loss17160897
    nsv912248CNV Loss21882294
    nsv833857CNV Loss17160897
    nsv912251CNV Loss21882294
    dgv3970n71CNV Loss21882294
    nsv912252CNV Loss21882294
    dgv592n67CNV Loss20364138
    esv22462CNV Gain19812545
    nsv9739CNV Gain+Loss18304495

    SABiosciences Cancer Mutation PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608825    OMIM disorders: --

    20/122 diseases for CGB5 (see all 122):    About MalaCards
    malignant sertoli cell tumor    corpus luteum cyst    gestational choriocarcinoma    ulcerative stomatitis
    gestational trophoblastic tumor    extragonadal germ cell tumor    partial hydatidiform mole    aromatase excess syndrome
    5-alpha reductase deficiency    malignant teratoma    3-methylcrotonyl-coa carboxylase deficiency    epithelioid trophoblastic tumor
    anorchia    placental site trophoblastic tumor    nonseminomatous germ cell tumor    mixed ductal-endocrine carcinoma
    congenital lipoid adrenal hyperplasia    malignant germ cell tumor    lipoid adrenal hyperplasia    testicular cancer

    1 disease from the University of Copenhagen DISEASES database for CGB5:
    Cryptococcosis

    CGB5 for disorders           About GeneDecksing

    10/93 Novoseek inferred disease relationships for CGB5 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 92.2 222 9833611 (5), 1889509 (4), 9826481 (4), 1967025 (4) (see all 99)
    trophoblastic disease 90.7 79 20116088 (6), 1710641 (3), 15346663 (3), 9833612 (3) (see all 40)
    hydatidiform mole 90 108 17462723 (6), 20116088 (5), 19155902 (4), 16711513 (3) (see all 51)
    gestational trophoblastic disease 89.1 78 9475142 (3), 15663134 (3), 17086808 (3), 15305826 (3) (see all 40)
    trophoblastic tumor 89 19 7712876 (2), 2167776 (2), 1661266 (1), 8492514 (1) (see all 16)
    trophoblastic tumor placental site 87.5 14 11972394 (1), 12748494 (1), 17701427 (1), 17086809 (1) (see all 7)
    gestational trophoblastic tumor 82.6 7 19004403 (1), 12681878 (1), 18762963 (1), 7970479 (1) (see all 5)
    pregnancy ectopic 81.5 90 16507931 (7), 7614131 (4), 14633876 (4), 16308901 (4) (see all 56)
    ovarian hyperstimulation syndrome 76.2 13 8005301 (1), 7920947 (1), 9240261 (1), 19573290 (1) (see all 10)
    hydatidiform mole invasive 74.2 4 19099349 (1), 19817556 (1)

    Genetic Association Database (GAD): CGB5
    Human Genome Epidemiology (HuGE) Navigator: CGB5 (4 documents)

    Export disorders for CGB5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CGB5 gene, integrated from 9 sources (see all 1210):
    (articles sorted by number of sources associating them with CGB5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PubMed id 6194155)1, 2, 3 Policastro P....Boime I. (1983)
    2. Genetic variation within the hypothalamus-pituitary-o varian axis in women with recurrent miscarriage. (PubMed id 20716560)1, 4 Hanna C.W....Robinson W.P. (2010)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (2010)
    4. Do placental genes affect maternal breast cancer? Association between offspring's CGB5 and CSH1 gene variants and maternal breast cancer risk. (PubMed id 19047151)1, 4 Chen Y....Ahsan H. (2008)
    5. Absence of the genetic variant Val79Met in human chorionic gonadotropin-beta gene 5 in five European populations. (PubMed id 15299093)1, 4 Jiang M....Huhtaniemi I. (2004)
    6. Crystal structure of human chorionic gonadotropin. (PubMed id 8202136)1, 2 Lapthorn A.J.... Isaacs N.W. (1994)
    7. A map of the hCG beta-LH beta gene cluster. (PubMed id 2422163)1, 2 Policastro P.F.... Boime I. (1986)
    8. Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. (PubMed id 6690982)1, 2 Talmadge K.... Fiddes J.C. (1984)
    9. The ISOBM TD-7 Workshop on hCG and related molecules. Towards user-oriented standardization of pregnancy and tumor diagnosis: assignment of epitopes to the three-dimensional structure of diagnostically and commercially relevant monoclonal antibodies directed against human chorionic gonadotropin and derivatives. (PubMed id 11893904)1, 9 Berger P....Stenman U.H. (2002)
    10. Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway activation. (PubMed id 17510243)1, 9 Kuorelahti A....Poutanen M. (2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
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      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 93659 HGNC: 16452 AceView: CGB5andCGB2 Ensembl:ENSG00000189052 euGenes: HUgn93659
    ECgene: CGB5 H-InvDB: CGB5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CGB5 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Human_chorionic_gonadotropin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CGB5 gene:
    Search GeneIP for patents involving CGB5

    GeneCards and IP:
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