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Aliases & Descriptions for CGB5
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| Aliases |
|---|
| CG-beta 3 | | CGB3 3 | | HCG 1, 2 | | MGC119822 2 |
| | | Descriptions |
|---|
| Chorionic gonadotrophin chain beta 3 | | chorionic gonadotropin beta 5 subunit 2 | | chorionic gonadotropin, beta polypeptide 5 2 |
|
| | Search outside databases for aliases for CGB5 genePrevious GC identifers: GC19P050194 GC19P049915 GC19P054223 GC19P054227 |
Summaries for CGB5(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for CGB5: This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq] UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy |
Genomic Location for CGB5
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the CGB5 gene 
Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.32CGB5 Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 19 GeneLoc Exon Structure GeneLoc location for GC19P054238:
(about GC identifiers)
Start:
|
54,238,875 bp from pter |
End:
|
54,240,380 bp from pter |
Size:
|
1,506 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000019.8 NT_011109.15
| Proteins for CGB5
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233 (See
protein sequence)Recommended Name: Choriogonadotropin subunit beta precursor Size: 165 amino acids; 17739 Da
Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin
Subcellular location: Secreted
Developmental stage: Made by the first trimester placenta
PDB structures from and Proteopedia :1HCN (3D)
 1HRP (3D)
 1QFW (3D)
 1XUL (3D)
 
Secondary accessions: Q13991 Q14000 Q3KPI3 Q3SY41 Q8WTT5 Q8WXL1 Q8WXL2 Q8WXL3 Q8WXL4Post-translational modifications:
View phosphorylation sites using PhosphoSite2
REFSEQ proteins: NP_149032.1
ENSEMBL proteins: ENSP00000301408
Human Recombinant Proteins Browse Origene for full length recombinant human proteins expressed in human HEK293 cells 
Antibodies for CGB5: Assays for CGB5: | Protein
Domains/ Families for CGB5(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P01233
ProtoNet protein and cluster: P01233 3 Blocks protein families: IPB001545 Gonadotropin IPB002400 Growth factor cystine knot superfamily signature IPB006208 Cystine knot domain
UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233Similarity: Belongs to the glycoprotein hormones subunit beta family | Gene Function for CGB5
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_033043
Applied Biosystems Silencer® siRNAs for CGB5
Browse siRNA at Sigma-Aldrich  Browse shRNA at Sigma-Aldrich  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_033043                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_033043                                  untagged cDNA clones in CMV expression vector (see all 2): NM_033043 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_033043
UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy | Pathways & Interactions for CGB5
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
5/9 Interacting proteins for CGB5 (ENSP000003014083 P012332) via UniProtKB, MINT, and/or STRING (see all 9
)About this table
|
Drugs & Compounds for CGB5(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for CGB5 UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233Pharmaceutical: Available under the names Novarel (Ferring) and Profasi (Serono). Used as adjunctive therapy in the treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting from caloric restriction, that it causes a more attractive or 'normal' distribution of fat, or that it decreases the hunger and discomfort associated with calorie-restricted diets 10/51 Novoseek chemical compound relationships for CGB5 gene (see all 51
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| progesterone |
79.30 |
475 |
18070493 (6), 7629236 (6), 8147233 (5), 11750960 (5) (see all 99) |
| estradiol |
70.01 |
132 |
18413150 (4), 19191722 (4), 2117066 (3), 1479151 (3) (see all 74) |
| b 152 |
66.32 |
6 |
17092638 (3) |
| 3beta-hydroxysteroid |
58.77 |
6 |
2149342 (1), 8187962 (1), 8964869 (1), 11384877 (1) (see all 6) |
| 17-hydroxyprogesterone |
58.69 |
14 |
9593605 (3), 1577246 (2), 9363253 (1), 10599984 (1) (see all 9) |
| 22r-hydroxycholesterol |
57.71 |
6 |
17431488 (1), 19330017 (1), 7556884 (1), 10613393 (1) |
| steroid |
56.69 |
50 |
7629236 (3), 10936036 (2), 7531411 (2), 18336931 (2) (see all 36) |
| 11-ketotestosterone |
55.15 |
20 |
12714013 (2), 9771643 (2), 15965976 (2), 9493828 (1) (see all 7) |
| androstenedione |
54.68 |
20 |
10600792 (3), 11870113 (2), 10685528 (2), 2158194 (1) (see all 15) |
| percoll |
49.52 |
8 |
2170316 (2), 1847300 (1), 2318939 (1), 1612524 (1) (see all 6) |
About this table
|
Transcripts for CGB5(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_033043
Browse siRNA at Sigma-Aldrich  Browse shRNA at Sigma-Aldrich  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_033043 REFSEQ mRNAs for CGB5 gene: NM_033043.1               OriGene GFP tagged cDNA clone in CMV expression vector: NM_033043                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_033043                                  untagged cDNA clones in CMV expression vector (see all 2): NM_033043  Additional cDNA sequence: BC006290.2 BC051378.1 BC103970.1 BC103971.1 BC106723.1 BC106724.1 BT006890.1 K03180.1 5 DOTS entries: DT.119691 DT.100837633 DT.97797965 DT.92436853 DT.95315378 24/247 AceView cDNA sequences (see all 247
):CA944648 BC069367 NM_033378 AA330859 BC051378 AA331012 BC006290 NM_033043 T50278 BU752275 BQ011219 AA330803 BE732062 CF527786 BG434117 AU139360 AI189842 BV195545 AI149559 BV199139 N40038 BE733206 BQ011244 AI871881
highest scoring ESTs for CGB5:CB998315 BT006890 BC051378 CB993686 AI868741 BE733206 BE903261 BG434117 BQ004107 BQ007333 Unigene Cluster for CGB5: Chorionic gonadotropin, beta polypeptide 5 Hs.590955 [show with all ESTs]Unigene Representative Sequence: BM916725
GeneLoc Exon Structure
1 Ensembl transcript including schematic representation: ENST00000301408
|
Expression for CGB5
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| CGB5 expression in normal and diseased human tissues
1 / 2 / 3 5 probe-sets matching CGB5 gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.590955 UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233Tissue specificity: Placenta |
Orthologs for CGB5
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CGB5 gene from 1 species
| Organism |
Gene |
Locus |
Description |
Human Similarity |
NCBI accessions |
chimpanzee (Pan troglodytes) |
CGB1 |
-- |
chorionic gonadotropin, beta polypeptide |
99.19(n) 98.18(a) |
747776 XM_001172080.1 XP_001172080.1 |
About this table Species with no ortholog for CGB5
ENSEMBL Gene Tree for CGB5 | Paralogs for CGB5(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| Paralogs for CGB5 gene
- CGB81 2 CGB1 2 TSHB2 CGB22 FSHB2 LHB2 GPHB52 CGB72
- CGB12
|
SNPs/Variants for CGB5(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for CGB5 (up to first 250kb)
|
Disorders & Mutations for CGB5
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 608825
10/91 Novoseek disease relationships for CGB5 gene (see all 91
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| choriocarcinoma |
92.07 |
211 |
9833611 (5), 1889509 (4), 9826481 (4), 1967025 (4) (see all 99) |
| trophoblastic disease |
90.42 |
68 |
1710641 (3), 9833612 (3), 8035374 (3), 15346663 (3) (see all 37) |
| hydatidiform mole |
90.11 |
102 |
17462723 (6), 19155902 (4), 16711513 (3), 1679110 (2) (see all 50) |
| gestational trophoblastic disease |
89.04 |
76 |
9475142 (3), 15663134 (3), 17086808 (3), 15305826 (3) (see all 39) |
| trophoblastic tumor |
89.03 |
18 |
7712876 (2), 2167776 (2), 1661266 (1), 8492514 (1) (see all 15) |
| trophoblastic tumor placental site |
87.59 |
14 |
11972394 (1), 12748494 (1), 17701427 (1), 17086809 (1) (see all 7) |
| gestational trophoblastic tumor |
81.90 |
7 |
19004403 (1), 12681878 (1), 18762963 (1), 7970479 (1) (see all 5) |
| pregnancy ectopic |
81.66 |
85 |
16507931 (7), 7614131 (4), 14633876 (4), 16308901 (4) (see all 54) |
| ovarian hyperstimulation syndrome |
75.28 |
10 |
8005301 (1), 7920947 (1), 9240261 (1), 14976788 (1) (see all 7) |
| hydatidiform mole invasive |
72.53 |
2 |
19099349 (1) |
About this table
Genetic Association Database: CGB5 Human Genome Epidemiology Navigator: CGB5 (2 documents)
|
Medical News for CGB5(Possibly Related Articles in
Doctor's Guide)
About This Section
| -- |
Publications for CGB5 (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/972 PubMed articles for CGB5 gene (see all 972
):- The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PubMed id 6194155)2, 3, 4 Policastro P....Boime I. (1983)
- Absence of the genetic variant Val79Met in human chorionic gonadotropin-beta gene 5 in five European populations. (PubMed id 15299093)3, 6 Jiang M....Huhtaniemi I. (2004)
- Crystal structure of human chorionic gonadotropin. (PubMed id 8202136)3, 4 Lapthorn A.J.... Isaacs N.W. (1994)
- A map of the hCG beta-LH beta gene cluster. (PubMed id 2422163)3, 4 Policastro P.F.... Boime I. (1986)
- Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. (PubMed id 6690982)3, 4 Talmadge K.... Fiddes J.C. (1984)
- The ISOBM TD-7 Workshop on hCG and related molecules. Towards user-oriented standardization of pregnancy and tumor diagnosis: assignment of epitopes to the three-dimensional structure of diagnostically and commercially relevant monoclonal antibodies directed against human chorionic gonadotropin and derivatives. (PubMed id 11893904)1, 3 Berger P....Stenman U.H. (2002)
- Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway activation. (PubMed id 17510243)1, 3 Kuorelahti A....Poutanen M. (2007)
- Single-chain human chorionic gonadotropin analogs containing the determinant loop of the beta-subunit linked to the alpha-subunit. (PubMed id 12914533)1, 3 Schubert R.L. and Puett D. (2003)
- A central role for Ets-2 in the transcriptional regulation and cyclic adenosine 5'-monophosphate responsiveness of the human chorionic gonadotropin-beta subunit gene. (PubMed id 12511603)1, 3 Ghosh D....Roberts R.M. (2003)
- Early first-trimester free beta-hCG and PAPP-A serum distributions in monochorionic and dichorionic twins. (PubMed id 19173346)3 Linskens I.H....van Vugt J.M. (2009)
|
Search for CGB5
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CGB5
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing CGB5
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CGB5(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| Wikipedia | http://en.wikipedia.org/wiki/Human_chorionic_gonadotropin |
|
| | | About This Section
| --
| Services for CGB5(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for CGB5:

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Incremental update: 13 Oct 2009
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