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CGB5 Gene

protein-coding   GIFtS: 50
GCID: GC19P049547

Chorionic Gonadotropin, Beta Polypeptide 5

  See CGB5-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chorionic Gonadotropin, Beta Polypeptide 51 2
HCG2
Chorionic Gonadotropin Beta 5 Subunit2
CG-beta3
CGB33
Chorionic Gonadotrophin Chain Beta3

External Ids:    HGNC: 164521   Entrez Gene: 936592   Ensembl: ENSG000001890527   OMIM: 6088255   UniProtKB: P012333   

Export aliases for CGB5 gene to outside databases

Previous GC identifers: GC19P050194 GC19P049915 GC19P054223 GC19P054227 GC19P054238 GC19P045923


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CGB5 Gene:
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic
gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta
subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and
stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta
subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and
contiguous with the luteinizing hormone beta subunit gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CGB5 Gene:
CGB5 (chorionic gonadotropin, beta polypeptide 5) is a protein-coding gene. Diseases associated with CGB5 include corpus luteum cyst, and malignant sertoli cell tumor. An important paralog of this gene is TSHB.

UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CGB5 gene promoter:
         NF-1   NF-1/L   Pax-5   POU3F1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCGB5 promoter sequence
   Search Chromatin IP Primers for CGB5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CGB5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.32

CGB5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CGB5 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19P049547:  view genomic region     (about GC identifiers)

Start:
49,547,102 bp from pter      End:
49,548,568 bp from pter
Size:
1,467 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233 (See protein sequence)
Recommended Name: Choriogonadotropin subunit beta precursor  
Size: 165 amino acids; 17739 Da
Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to
thyrotropin, lutropin, follitropin and gonadotropin
Developmental stage: Made by the first trimester placenta
Sequence caution: Sequence=CAA25068.1; Type=Erroneous initiation; Sequence=CAA25069.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for CGB5:
1HCN (3D)        1HRP (3D)        1QFW (3D)        1XUL (3D)    
Secondary accessions: A1A5E0 B9ZVP5 Q13991 Q14000 Q3KPI3 Q3SY41 Q8WTT5 Q8WXL1 Q8WXL2 Q8WXL3
Q8WXL4
Alternative splicing: 2 isoforms:  P01233-1   P01233-2   (Ref.2 (CAA25069) sequence is in conflict in positions: 7:G->R, 9:A->V, 12:D->G)

Explore the universe of human proteins at neXtProt for CGB5: NX_P01233

Explore proteomics data for CGB5 at MOPED

Post-translational modifications: 

  • Modification sites at neXtProt
  • Modification sites at PhosphoSitePlus

  • See CGB5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_149032.1  
    ENSEMBL proteins: 
     ENSP00000301408  
    Reactome Protein details: P01233

    CGB5 Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for CGB5 (7 products) 

     
    antibodies-online peptides for CGB5

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    antibodies-online antibodies for CGB5 (38 products) 

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    3 InterPro protein domains:
     IPR018245 Gonadotropin_bsu_CS
     IPR001545 Gonadotropin_bsu
     IPR006208 Cys_knot

    Graphical View of Domain Structure for InterPro Entry P01233

    ProtoNet protein and cluster: P01233

    3 Blocks protein domains:
    IPB001545 Gonadotropin
    IPB002400 Growth factor cystine knot superfamily signature
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Similarity: Belongs to the glycoprotein hormones subunit beta family


    Find genes that share domains with CGB5           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CGHB_HUMAN, P01233
    Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity ----
         
    Find genes that share ontologies with CGB5           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CGB5
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CGHB_HUMAN, P01233: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol1
    endoplasmic reticulum1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region ----

    Find genes that share ontologies with CGB5           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CGB5 About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Peptide hormone biosynthesis0.00
    Glycoprotein hormones0.00
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30


    Find genes that share SuperPaths with CGB5           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CGB5
        Glycoprotein hormones


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CGB5
    Interactions:

        Search GeneGlobe Interaction Network for CGB5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    Selected Interacting proteins for CGB5 (P012332, 3 ENSP000003014084) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CGAP012152, 3, ENSP000003585954MINT-24926 I2D: score=5 STRING: ENSP00000358595
    CKBP122773I2D: score=1 
    EWSR1Q018443I2D: score=1 
    FSHBP012253I2D: score=1 
    LHCGRP228883I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process ----
    GO:0007165signal transduction ----
    GO:0007267cell-cell signaling ----
    GO:0007292female gamete generation ----
    GO:0016486peptide hormone processing ----

    Find genes that share ontologies with CGB5           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CGB5 (CGHB)

    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Pharmaceutical: Available under the names Novarel (Ferring) and Profasi (Serono). Used as adjunctive therapy in
    the treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting
    from caloric restriction, that it causes a more attractive or 'normal' distribution of fat, or that it decreases
    the hunger and discomfort associated with calorie-restricted diets

    Selected Novoseek inferred chemical compound relationships for CGB5 gene (see all 140)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    progesterone 79.4 499 18070493 (6), 20503230 (6), 7629236 (6), 8147233 (5) (see all 99)
    testosterone 73.2 344 7629236 (6), 17477304 (5), 12220777 (5), 12538621 (4) (see all 99)
    gnrh 72.2 267 7852524 (10), 8114013 (7), 7951519 (6), 1517367 (6) (see all 84)
    estradiol 69.8 139 18413150 (4), 19191722 (4), 2117066 (3), 1479151 (3) (see all 78)
    b 152 65.9 6 17092638 (3)
    methotrexate 61.7 82 16313819 (4), 11919242 (4), 17173905 (4), 9302177 (4) (see all 36)
    3beta-hydroxysteroid 60.1 7 19501915 (1), 2149342 (1), 8187962 (1), 8964869 (1) (see all 7)
    11-ketotestosterone 58.6 23 12714013 (2), 9771643 (2), 15965976 (2), 9493828 (1) (see all 9)
    17-hydroxyprogesterone 57.6 14 9593605 (3), 1577246 (2), 9363253 (1), 10599984 (1) (see all 9)
    22r-hydroxycholesterol 57 6 17431488 (1), 19330017 (1), 7556884 (1), 10613393 (1)



    Find genes that share compounds with CGB5           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CGB5 gene: 
    NM_033043.1  

    Unigene Cluster for CGB5:

    Chorionic gonadotropin, beta polypeptide 5
    Hs.172944  [show with all ESTs]
    Unigene Representative Sequence: BM916725
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000301408(uc002ply.3)
    miRNA
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      QuantiFast Probe-based Assays in human, mouse, rat CGB5

    Additional mRNA sequence: 

    BC006290.2 BC051378.1 BC103970.1 BC103971.1 BC106723.1 BC106724.1 BT006890.1 K03180.1 

    5 DOTS entries:

    DT.119691  DT.97797965  DT.100837633  DT.92436853  DT.95315378 

    Selected AceView cDNA sequences (see all 247):

    BC069367 NM_033043 BC006290 NM_033378 AA331012 AA330859 T50278 CA944648 
    BC051378 AA330755 BE901661 BX439414 N32108 AI417614 BQ011219 N29831 
    BQ004041 AI871881 BU752320 BX358708 H93656 NM_033183 BX358522 BU630393 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CGB5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CGB5 Expression
    About this image


    CGB5 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Placenta (Extraembryonic Tissues)
             Syncytiotrophoblast-like cells
     
     Neurons
             GABA neuron-like cells
     
     Brain (Nervous System)
             GABA neuron-like cells
    CGB5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CGB5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.172944

    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Tissue specificity: Placenta

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CGB5 gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    36(a)
    1 → many
    6(80158039-80158659)
    zebrafish
    (Danio rerio)
    Actinopterygii lhb6
    luteinizing hormone, beta polypeptide
    39(a)
    1 → many
    Zv9_scaffold3525(54871-57837) ENSDARG00000035709
            Species with no ortholog for CGB5

    ENSEMBL Gene Tree for CGB5 (if available)
    TreeFam Gene Tree for CGB5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CGB5 gene
    CGB81 2  CGB1 2  TSHB2  FSHB2  CGB22  LHB2  ENSG000002673352  CGB72  
    CGB12  
    7 SIMAP similar genes for CGB5 using alignment to 1 protein entry:     CGHB_HUMAN:
    CGB8    CGB1    CGB2    CGB7    LHB    FSHB
    TSHB

    Find genes that share paralogs with CGB5           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CGB5 (see all 156)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1829806811,2
    --49545169(+) ACAAGA/TTGGGT 1 -- us2k10--------
    rs1131773791,2
    C,F--49545179(+) TGTTAC/TGCAAG 1 -- us2k11Minor allele frequency- T:0.50CSA 2
    rs104197391,2
    C,F--49545226(+) GGCTTT/CCCCAT 1 -- us2k15Minor allele frequency- C:0.40NA WA 10
    rs1405126441,2
    --49545262(+) GGGTTC/TCCAAC 1 -- us2k10--------
    rs1458935001,2
    --49545327(+) TGTCTC/TCATGT 1 -- us2k10--------
    rs2013464381,2
    --49545334(+) ATGTG-/CTCTGAG 1 -- us2k10--------
    rs1876114121,2
    --49545370(+) TCCCCC/TAGACT 1 -- us2k10--------
    rs1917760411,2
    --49545382(+) CCTCTA/GCATCC 1 -- us2k10--------
    rs1413406061,2
    --49545441(+) CTCGAA/CATTGT 1 -- us2k10--------
    rs1843200651,2
    --49545457(+) TTTCCC/TGATCC 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CGB5 (49547102 - 49548568 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CGB5:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2718698CNV Deletion23290073
    nsv833859CNV Loss17160897
    nsv912248CNV Loss21882294
    nsv833857CNV Loss17160897
    nsv912251CNV Loss21882294
    dgv3970n71CNV Loss21882294
    nsv912252CNV Loss21882294
    dgv592n67CNV Loss20364138
    esv22462CNV Gain19812545
    nsv9739CNV Gain+Loss18304495

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608825    OMIM disorders: --

    Selected diseases for CGB5 (see all 26):    
    About MalaCards
    corpus luteum cyst    malignant sertoli cell tumor    gestational choriocarcinoma    malignant teratoma
    aromatase excess syndrome    gestational trophoblastic tumor    partial hydatidiform mole    anorchia
    extragonadal germ cell tumor    placental site trophoblastic tumor    nonseminomatous germ cell tumor    epithelioid trophoblastic tumor
    malignant germ cell tumor    anencephaly    testicular cancer    lipoid adrenal hyperplasia
    hydrocele    gestational trophoblastic neoplasm    choriocarcinoma    trophoblastic neoplasm

    1 disease from the University of Copenhagen DISEASES database for CGB5:
    Cryptococcosis

    Find genes that share disorders with CGB5           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CGB5 gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    choriocarcinoma 92.2 222 9833611 (5), 1889509 (4), 9826481 (4), 1967025 (4) (see all 99)
    trophoblastic disease 90.7 79 20116088 (6), 1710641 (3), 15346663 (3), 9833612 (3) (see all 40)
    hydatidiform mole 90 108 17462723 (6), 20116088 (5), 19155902 (4), 16711513 (3) (see all 51)
    gestational trophoblastic disease 89.1 78 9475142 (3), 15663134 (3), 17086808 (3), 15305826 (3) (see all 40)
    trophoblastic tumor 89 19 7712876 (2), 2167776 (2), 1661266 (1), 8492514 (1) (see all 16)
    trophoblastic tumor placental site 87.5 14 11972394 (1), 12748494 (1), 17701427 (1), 17086809 (1) (see all 7)
    gestational trophoblastic tumor 82.6 7 19004403 (1), 12681878 (1), 18762963 (1), 7970479 (1) (see all 5)
    pregnancy ectopic 81.5 90 16507931 (7), 7614131 (4), 14633876 (4), 16308901 (4) (see all 56)
    ovarian hyperstimulation syndrome 76.2 13 8005301 (1), 7920947 (1), 9240261 (1), 19573290 (1) (see all 10)
    hydatidiform mole invasive 74.2 4 19099349 (1), 19817556 (1)

    Genetic Association Database (GAD): CGB5
    Human Genome Epidemiology (HuGE) Navigator: CGB5 (4 documents)

    Export disorders for CGB5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CGB5 gene, integrated from 10 sources (see all 1210):
    (articles sorted by number of sources associating them with CGB5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PubMed id 6194155)1, 2, 3 Policastro P....Boime I. (J. Biol. Chem. 1983)
    2. Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage. (PubMed id 20716560)1, 4 Hanna C.W....Robinson W.P. (Hum. Reprod. 2010)
    3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    4. Do placental genes affect maternal breast cancer? Association between offspring's CGB5 and CSH1 gene variants and maternal breast cancer risk. (PubMed id 19047151)1, 4 Chen Y....Ahsan H. (Cancer Res. 2008)
    5. Absence of the genetic variant Val79Met in human chorionic gonadotropin-beta gene 5 in five European populations. (PubMed id 15299093)1, 4 Jiang M....Huhtaniemi I. (Mol. Hum. Reprod. 2004)
    6. Crystal structure of human chorionic gonadotropin. (PubMed id 8202136)1, 2 Lapthorn A.J.... Isaacs N.W. (Nature 1994)
    7. A map of the hCG beta-LH beta gene cluster. (PubMed id 2422163)1, 2 Policastro P.F.... Boime I. (J. Biol. Chem. 1986)
    8. Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. (PubMed id 6690982)1, 2 Talmadge K.... Fiddes J.C. (Nature 1984)
    9. The ISOBM TD-7 Workshop on hCG and related molecules. Towards user-oriented standardization of pregnancy and tumor diagnosis: assignment of epitopes to the three-dimensional structure of diagnostically and commercially relevant monoclonal antibodies directed against human chorionic gonadotropin and derivatives. (PubMed id 11893904)1, 9 Berger P....Stenman U.H. (Tumour Biol. 2002)
    10. Human chorionic gonadotropin (hCG) up-regulates wnt5b and wnt7b in the mammary gland, and hCGbeta transgenic female mice present with mammary Gland tumors exhibiting characteristics of the Wnt/beta-catenin pathway activation. (PubMed id 17510243)1, 9 Kuorelahti A....Poutanen M. (Endocrinology 2007)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 93659 HGNC: 16452 AceView: CGB5andCGB2 Ensembl:ENSG00000189052 euGenes: HUgn93659
    ECgene: CGB5 H-InvDB: CGB5

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CGB5 Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Human_chorionic_gonadotropin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CGB5 gene:
    Search GeneIP for patents involving CGB5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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