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Aliases for CGB5 Gene

Aliases for CGB5 Gene

  • Chorionic Gonadotropin Beta Subunit 5 2 3 5
  • Chorionic Gonadotropin, Beta Polypeptide 5 2 3
  • CGB 3 4
  • Chorionic Gonadotropin Beta 5 Subunit 3
  • Chorionic Gonadotropin Chain Beta 4
  • Choriogonadotropin Subunit Beta 4
  • CGB3 CGB5 CGB8 4
  • CG-Beta 4
  • HCGB 3
  • HCG 3

External Ids for CGB5 Gene

Previous GeneCards Identifiers for CGB5 Gene

  • GC19P050194
  • GC19P049915
  • GC19P054223
  • GC19P054227
  • GC19P054238
  • GC19P049547
  • GC19P045923

Summaries for CGB5 Gene

Entrez Gene Summary for CGB5 Gene

  • This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 5 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CGB5 Gene

CGB5 (Chorionic Gonadotropin Beta Subunit 5) is a Protein Coding gene. Diseases associated with CGB5 include Gestational Trophoblastic Tumor and Placental Site Trophoblastic Tumor. Among its related pathways are Gene Expression and Metabolism of proteins. GO annotations related to this gene include hormone activity. An important paralog of this gene is CGB3.

UniProtKB/Swiss-Prot for CGB5 Gene

  • Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGB5 Gene

Genomics for CGB5 Gene

Regulatory Elements for CGB5 Gene

Enhancers for CGB5 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH19G049020 0.8 FANTOM5 6.1 -22.8 -22777 0.3 MAZ SP3 KLF1 BHLHE40 SP2 MNT ZNF2 KLF16 ZNF692 ZNF169 CGB3 GYS1 RUVBL2 CGB7 NTF4 CGB5 LOC101059948
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CGB5 on UCSC Golden Path with GeneCards custom track

Genomic Location for CGB5 Gene

Chromosome:
19
Start:
49,043,845 bp from pter
End:
49,045,311 bp from pter
Size:
1,467 bases
Orientation:
Plus strand

Genomic View for CGB5 Gene

Genes around CGB5 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGB5 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGB5 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGB5 Gene

Proteins for CGB5 Gene

  • Protein details for CGB5 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0DN86-CGB3_HUMAN
    Recommended name:
    Choriogonadotropin subunit beta 3
    Protein Accession:
    P0DN86
    Secondary Accessions:
    • A1A5E0
    • B9ZVP5
    • P01233
    • Q13991
    • Q14000
    • Q3KPI3
    • Q3SY41
    • Q8WTT5
    • Q8WXL1
    • Q8WXL2
    • Q8WXL3
    • Q8WXL4

    Protein attributes for CGB5 Gene

    Size:
    165 amino acids
    Molecular mass:
    17739 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain identical in LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones.
    • Heterodimer of a common alpha chain identical in LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones.
    • Heterodimer of a common alpha chain identical in LH, FSH, TSH and HCG and a unique beta chain distinct in each of the hormones.
    Miscellaneous:
    • Encoded by a cluster of genes that have evolved by duplication from LHB. HCG-beta is encoded by six non-allelic genes (CGB) clustered on chromosome 19q13.3 and named CGB1, CGB2, CGB3, CGB5, CGB7 and CGB8. Two specific CGB proteins that differ by three amino acids in positions 2,4 and 117 have been described: type 1 (CGB7) and type 2 (CGB3, CGB5, CGB8).
    SequenceCaution:
    • Sequence=CAA25068.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA25069.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CGB5 Gene

    Alternative splice isoforms for CGB5 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CGB5 Gene

Post-translational modifications for CGB5 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CGB5 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CGB5 Gene

Domains & Families for CGB5 Gene

Graphical View of Domain Structure for InterPro Entry

P0DN86

UniProtKB/Swiss-Prot:

CGB3_HUMAN :
  • Belongs to the glycoprotein hormones subunit beta family.
Family:
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with CGB5: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CGB5 Gene

Function for CGB5 Gene

Molecular function for CGB5 Gene

UniProtKB/Swiss-Prot Function:
Beta subunit of the human chorionic gonadotropin (hCG). hCG is a complex glycoprotein composed of two glycosylated subunits alpha and beta which are non-covalently associated. The alpha subunit is identical to those in the pituitary gonadotropin hormones (LH, FSH and TSH). The beta subunits are distinct in each of the hormones and confer receptor and biological specificity. Has an essential role in pregnancy and maternal adaptation. Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy.
genes like me logo Genes that share phenotypes with CGB5: view

Animal Model Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CGB5

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CGB5 Gene

Localization for CGB5 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGB5 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CGB5 gene
Compartment Confidence
extracellular 3

Gene Ontology (GO) - Cellular Components for CGB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with CGB5: view

Pathways & Interactions for CGB5 Gene

genes like me logo Genes that share pathways with CGB5: view

Interacting Proteins for CGB5 Gene

Gene Ontology (GO) - Biological Process for CGB5 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006357 regulation of transcription from RNA polymerase II promoter TAS --
GO:0006915 apoptotic process TAS --
GO:0007165 signal transduction TAS --
GO:0007267 cell-cell signaling TAS --
GO:0007292 female gamete generation TAS --
genes like me logo Genes that share ontologies with CGB5: view

No data available for SIGNOR curated interactions for CGB5 Gene

Drugs & Compounds for CGB5 Gene

(86) Drugs for CGB5 Gene - From: ApexBio and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Luteinizing hormone releasing hormone human acetate salt (LHRH) Pharma 0

(55) Additional Compounds for CGB5 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs

(1) ApexBio Compounds for CGB5 Gene

genes like me logo Genes that share compounds with CGB5: view

Drug Products

Transcripts for CGB5 Gene

mRNA/cDNA for CGB5 Gene

(1) REFSEQ mRNAs :
(8) Additional mRNA sequences :
(247) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CGB5 Gene

Chorionic gonadotropin, beta polypeptide 5:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CGB5

Alternative Splicing Database (ASD) splice patterns (SP) for CGB5 Gene

No ASD Table

Relevant External Links for CGB5 Gene

GeneLoc Exon Structure for
CGB5
ECgene alternative splicing isoforms for
CGB5

Expression for CGB5 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CGB5 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CGB5 Gene

This gene is overexpressed in Testis (x18.0), Skin - Sun Exposed (Lower leg) (x6.2), Skin - Not Sun Exposed (Suprapubic) (x6.1), Prostate (x5.2), and Pituitary (x5.1).

NURSA nuclear receptor signaling pathways regulating expression of CGB5 Gene:

CGB5

SOURCE GeneReport for Unigene cluster for CGB5 Gene:

Hs.172944

mRNA Expression by UniProt/SwissProt for CGB5 Gene:

P0DN86-CGB3_HUMAN
Tissue specificity: High expression in the placenta throughout pregnancy.
genes like me logo Genes that share expression patterns with CGB5: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CGB5 Gene

Orthologs for CGB5 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGB5 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 35
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia LHB 35
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LHB 35
  • 64 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Lhb 35
  • 62 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia LHB 35
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii lhb 35
  • 39 (a)
OneToMany
Species where no ortholog for CGB5 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGB5 Gene

ENSEMBL:
Gene Tree for CGB5 (if available)
TreeFam:
Gene Tree for CGB5 (if available)

Paralogs for CGB5 Gene

Paralogs for CGB5 Gene

(7) SIMAP similar genes for CGB5 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CGB5: view

Variants for CGB5 Gene

Sequence variations from dbSNP and Humsavar for CGB5 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type
rs1000188968 -- 49,043,932(+) TCCCT(A/G)TGCCT utr-variant-5-prime
rs1000919603 -- 49,043,061(+) TGGTG(A/T)CCTTT upstream-variant-2KB
rs1001093950 -- 49,042,904(+) ACATG(C/G)GGTTT upstream-variant-2KB
rs1001308378 -- 49,045,660(+) ATCCC(A/G)CCATT downstream-variant-500B
rs1002935764 -- 49,042,106(+) CTCCC(A/G)CTCCC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CGB5 Gene

Variant ID Type Subtype PubMed ID
dgv592n67 CNV loss 20364138
esv22462 CNV gain 19812545
esv2718698 CNV deletion 23290073
nsv579907 CNV loss 21841781
nsv833857 CNV loss 17160897
nsv833859 CNV loss 17160897
nsv953598 CNV deletion 24416366
nsv9739 CNV gain+loss 18304495
nsv978832 CNV duplication 23825009

Variation tolerance for CGB5 Gene

Gene Damage Index Score: 0.57; 12.39% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CGB5 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CGB5

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGB5 Gene

Disorders for CGB5 Gene

MalaCards: The human disease database

(19) MalaCards diseases for CGB5 Gene - From: Novoseek and GeneCards

Disorder Aliases PubMed IDs
gestational trophoblastic tumor
  • gestational trophoblastic disease
placental site trophoblastic tumor
  • placental-site gestational trophoblastic neoplasm
hydatidiform mole, recurrent, 1
  • complete hydatidiform mole
invasive mole
  • hydatidiform mole, invasive
5-alpha reductase deficiency
  • pseudovaginal perineoscrotal hypospadias
- elite association - COSMIC cancer census association via MalaCards
Search CGB5 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CGB5

Genetic Association Database (GAD)
CGB5
Human Genome Epidemiology (HuGE) Navigator
CGB5
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CGB5
genes like me logo Genes that share disorders with CGB5: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CGB5 Gene

Publications for CGB5 Gene

  1. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PMID: 6194155) Policastro P. … Boime I. (J. Biol. Chem. 1983) 2 3 4 64
  2. Genetic variation within the hypothalamus-pituitary-ovarian axis in women with recurrent miscarriage. (PMID: 20716560) Hanna C.W. … Robinson W.P. (Hum. Reprod. 2010) 3 46 64
  3. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PMID: 20734064) He C. … Hunter D.J. (Hum. Genet. 2010) 3 46 64
  4. Do placental genes affect maternal breast cancer? Association between offspring's CGB5 and CSH1 gene variants and maternal breast cancer risk. (PMID: 19047151) Chen Y. … Ahsan H. (Cancer Res. 2008) 3 46 64
  5. Absence of the genetic variant Val79Met in human chorionic gonadotropin-beta gene 5 in five European populations. (PMID: 15299093) Jiang M. … Huhtaniemi I. (Mol. Hum. Reprod. 2004) 3 46 64

Products for CGB5 Gene

Sources for CGB5 Gene

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