Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CGB2 Gene

Aliases for CGB2 Gene

  • Chorionic Gonadotropin, Beta Polypeptide 2 2 3

External Ids for CGB2 Gene

Previous GeneCards Identifiers for CGB2 Gene

  • GC19P050193
  • GC19P049866
  • GC19P054211
  • GC19P054226
  • GC19P049535
  • GC19P045911

Summaries for CGB2 Gene

Entrez Gene Summary for CGB2 Gene

  • The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 163 aa protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits. [provided by RefSeq, Jul 2008]

GeneCards Summary for CGB2 Gene

CGB2 (Chorionic Gonadotropin, Beta Polypeptide 2) is a Protein Coding gene. GO annotations related to this gene include hormone activity. An important paralog of this gene is TSHB.

Gene Wiki entry for CGB2 Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGB2 Gene

Genomics for CGB2 Gene

Regulatory Elements for CGB2 Gene

Genomic Location for CGB2 Gene

Start:
49,031,873 bp from pter
End:
49,033,238 bp from pter
Size:
1,366 bases
Orientation:
Plus strand

Genomic View for CGB2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CGB2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGB2 Gene

Proteins for CGB2 Gene

  • Protein details for CGB2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6NT52-CGB2_HUMAN
    Recommended name:
    Choriogonadotropin subunit beta variant 2
    Protein Accession:
    Q6NT52
    Secondary Accessions:
    • B9ZVM5

    Protein attributes for CGB2 Gene

    Size:
    195 amino acids
    Molecular mass:
    21221 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CGB2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CGB2 Gene

Proteomics data for CGB2 Gene at MOPED

Post-translational modifications for CGB2 Gene

  • Glycosylation at Asn63 and Asn80
  • Modification sites at PhosphoSitePlus

Other Protein References for CGB2 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CGB2 Gene

Domains for CGB2 Gene

Suggested Antigen Peptide Sequences for CGB2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6NT52

UniProtKB/Swiss-Prot:

CGB2_HUMAN :
  • Q6NT52
Family:
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with CGB2: view

No data available for Gene Families for CGB2 Gene

Function for CGB2 Gene

Gene Ontology (GO) - Molecular Function for CGB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IMP 19523396
genes like me logo Genes that share ontologies with CGB2: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CGB2 Gene

Localization for CGB2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGB2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CGB2 Gene COMPARTMENTS Subcellular localization image for CGB2 gene
Compartment Confidence
extracellular 5
cytosol 3

Gene Ontology (GO) - Cellular Components for CGB2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CGB2: view

Pathways for CGB2 Gene

SuperPathways for CGB2 Gene

No Data Available

Interacting Proteins for CGB2 Gene

Gene Ontology (GO) - Biological Process for CGB2 Gene

None

No data available for Pathways by source for CGB2 Gene

Transcripts for CGB2 Gene

mRNA/cDNA for CGB2 Gene

(247) Selected AceView cDNA sequences:
(2) Additional mRNA sequences :
(3) REFSEQ mRNAs :
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CGB2 Gene

Chorionic gonadotropin, beta polypeptide 2:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CGB2

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CGB2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CGB2 Gene

No ASD Table

Relevant External Links for CGB2 Gene

GeneLoc Exon Structure for
CGB2
ECgene alternative splicing isoforms for
CGB2

Expression for CGB2 Gene

mRNA expression in normal human tissues for CGB2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CGB2 Gene

This gene is overexpressed in Testis (15.7), Brain - Putamen (basal ganglia) (10.4), Brain - Caudate (basal ganglia) (5.2), Brain - Nucleus accumbens (basal ganglia) (4.1), and Brain - Hippocampus (4.0).

Integrated Proteomics: protein expression from ProteomicsDB, MOPED, and MaxQB for CGB2 Gene

SOURCE GeneReport for Unigene cluster for CGB2 Gene Hs.567650

mRNA Expression by UniProt/SwissProt for CGB2 Gene

Q6NT52-CGB2_HUMAN
Tissue specificity: Expressed in placenta, testis and pituitary.
genes like me logo Genes that share expressions with CGB2: view

In Situ Assay Products

Orthologs for CGB2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGB2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LHB 36
  • 62 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LHB 36
  • 62 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Lhb 36
  • 60 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia LHB 36
  • 54 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 37 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii lhb 36
  • 39 (a)
OneToMany
Species with no ortholog for CGB2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGB2 Gene

ENSEMBL:
Gene Tree for CGB2 (if available)
TreeFam:
Gene Tree for CGB2 (if available)

Paralogs for CGB2 Gene

Paralogs for CGB2 Gene

Selected SIMAP similar genes for CGB2 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CGB2: view

Variants for CGB2 Gene

Sequence variations from dbSNP and Humsavar for CGB2 Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs10423094 -- 49,030,123(+) CACCT(G/T)CTTCA upstream-variant-2KB
rs10423859 -- 49,029,906(+) CCTTT(C/T)GGGAG upstream-variant-2KB
rs34344176 -- 49,030,466(+) AAATC(A/T)CAACT upstream-variant-2KB
rs35420394 -- 49,030,592(+) AATAG(C/G)CACTA upstream-variant-2KB
rs60506574 -- 49,031,136(+) TCCTC(C/T)GAGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CGB2 Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833857 CNV Loss 17160897
nsv912248 CNV Loss 21882294
dgv3970n71 CNV Loss 21882294
nsv833859 CNV Loss 17160897
nsv912251 CNV Loss 21882294
esv22462 CNV Gain 19812545
nsv912252 CNV Loss 21882294
dgv592n67 CNV Loss 20364138
esv2718698 CNV Deletion 23290073

Relevant External Links for CGB2 Gene

HapMap Linkage Disequilibrium report
CGB2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGB2 Gene

Disorders for CGB2 Gene

No disorders were found for CGB2 Gene.

No data available for UniProtKB/Swiss-Prot for CGB2 Gene

Publications for CGB2 Gene

  1. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PMID: 6194155) Policastro P. … Boime I. (J. Biol. Chem. 1983) 2 3
  2. The evolution and genomic landscape of CGB1 and CGB2 genes. (PMID: 17055150) Hallast P. … Laan M. (Mol. Cell. Endocrinol. 2007) 3 23
  3. Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo. (PMID: 1371113) Bo M. … Boime I. (J. Biol. Chem. 1992) 3
  4. A map of the hCG beta-LH beta gene cluster. (PMID: 2422163) Policastro P.F. … Boime I. (J. Biol. Chem. 1986) 3
  5. The beta chorionic gonadotropin-beta luteinizing gene cluster maps to human chromosome 19. (PMID: 6204923) Julier C. … Junien C. (Hum. Genet. 1984) 3

Products for CGB2 Gene

Sources for CGB2 Gene

Back to Top

Content