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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CGB2 Gene

protein-coding GIFtS: 40
GCID: GC19P049535

chorionic gonadotropin, beta polypeptide 2

Search for CGB2
in

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chorionic Gonadotropin, Beta Polypeptide 2¹ ²
Choriogonadotropin Subunit Beta Variant 2²
Product Of CGB2²

External Ids:	HGNC: 16722¹	Entrez Gene: 114336²	Ensembl: ENSG00000104818⁷	OMIM: 608824⁵	UniProtKB: Q6NT52³

Export aliases for CGB2 gene to outside databases

Previous GC identifers: GC19P050193 GC19P049866 GC19P054211 GC19P054226 GC19P045911

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CGB2:

The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar genes

that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing hormone beta

(LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed region. This gene

was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit, however, detection of CGB1 and

CGB2 transcripts in vivo, and their presence on the polysomes, suggested that these transcripts are translated. To

date, a protein product corresponding to CGB2 has not been isolated. The deduced sequence of the hypothetical protein

of 132 aa does not share any similarity with that of functional CGB subunits (PMID:8954017). However, a 163 aa

protein, translated from a different frame, is about the same size, and shares 98% identity with other CGB subunits.

(provided by RefSeq, Jul 2008)

Gene Wiki entry for CGB2

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CGB2 gene promoter:
Egr-3 AhR NF-1/L NF-1 Pax-5 GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CGB2 promoter sequence

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CGB2

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.32

CGB2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CGB2 gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19P049535: view genomic region (about GC identifiers)

Start:	49,535,130 bp from pter	End:	49,536,495 bp from pter
Size:	1,366 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CGB2_HUMAN, Q6NT52 (See protein sequence)

Recommended Name: Choriogonadotropin subunit beta variant 2 precursor

Size: 195 amino acids; 21221 Da

Subcellular location: Secreted

Secondary accessions: B9ZVM5

Alternative splicing: 2 isoforms: Q6NT52-1 Q6NT52-2 (Does not have any homology with the functional beta-subunit. This change has been caused by an inserted DNA fragment within the 5'-UTR of CGB2 providing a novel exon 1 as well as a 1 bp shifted ORF for exons 2 and 3)

Explore the universe of human proteins at neXtProt for CGB2: NX_Q6NT52

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6NT52

CGB2 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_203696.2

ENSEMBL proteins:

ENSP00000352295

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

CGB2 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CGB2 for domains About GeneDecksing

3 InterPro domains/families:

IPR018245 Gonadotropin_bsu_CS

IPR001545 Gonadotropin_bsu

IPR006208 Cys_knot

Graphical View of Domain Structure for InterPro Entry Q6NT52

ProtoNet protein and cluster: Q6NT52

1 Blocks protein family: IPB002400 Growth factor cystine knot superfamily signature

UniProtKB/Swiss-Prot: CGB2_HUMAN, Q6NT52

Similarity: Belongs to the glycoprotein hormones subunit beta family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	IEA	--

CGB2 for ontologies About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CGB2

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

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(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for CGB2 gene:

NM_033378.1

Unigene Cluster for CGB2:

Chorionic gonadotropin, beta polypeptide 2

Hs.567650 [show with all ESTs]

Unigene Representative Sequence: BC107143

2 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000474913(uc010yaf.2) ENST00000359342(uc002plw.3)

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Additional cDNA sequence:

BC069367.1 BC107143.1

4 DOTS entries:

DT.100044715 DT.121475007 DT.100837633 DT.97797965

24/247 AceView cDNA sequences (see all 247):

AA331012 NM_033043 NM_033378 CA944648 T50278 AA330859 BC069367 BC006290

BC051378 AI149072 AI160579 AI871881 CF528171 BE733206 BU752248 BT006890

N32108 BU752275 AI160936 AI189842 AI138197 BU752315 BU752320 BX358708

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CGB2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: --

About this image
See CGB2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CGB2

SOURCE GeneReport for Unigene cluster: Hs.567650

UniProtKB/Swiss-Prot: CGB2_HUMAN, Q6NT52

Tissue specificity: Expressed in placenta, testis and pituitary

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CGB2 gene from 2/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	--	--	37(a)	1 → many	6(80158039-80158659)
zebrafish (Danio rerio)	Actinopterygii	lhb⁶	luteinizing hormone, beta polypeptide	40(a)	1 → many	Zv9_scaffold3525(54871-57837)

ENSEMBL Gene Tree for CGB2 (if available)
TreeFam Gene Tree for CGB2 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CGB2 gene

TSHB² FSHB² LHB² CGB8² ENSG00000267335² CGB² CGB5² CGB7²

CGB1²

8 SIMAP similar genes for CGB2 using alignment to 3 protein entries: CGB2_HUMAN (see all proteins):

CGB CGB5 CGB8 CGB7 CGB1 LHB

FSHB TSHB

CGB2 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs60506574^1,2	C,F	--	49534393(+)	`TCCTCC/TGAGGC`	1	--	us2k¹		2		NA	4
rs62126037^1,2	C,F,	--	49534401(+)	`GGCTGC/AGGCCT`	1	--	us2k¹		2		NA	4
rs182770744^1,2		--	49534518(+)	`TGGGCA/GGAGGT`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs186761872^1,2		--	49534775(+)	`GCTGAC/GAGGCA`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs138110233^1,2		--	49534799(+)	`AGGACA/CGAGCA`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs192491737^1,2		--	49534855(+)	`AAAACA/TCTTAG`	2	--	ds500¹ us2k¹		0	--	--	--	--
rs184850750^1,2		--	49534872(+)	`GTCATA/TTCTTC`	2	--	us2k¹ ds500¹		0	--	--	--	--
rs188788677^1,2		--	49534877(+)	`TTCTTC/TCTATC`	2	--	us2k¹ ds500¹		0	--	--	--	--
rs193155384^1,2		--	49534887(+)	`CAAGGA/CGTCCT`	2	--	us2k¹ ds500¹		0	--	--	--	--
rs117214522^1,2	F,	--	49534904(+)	`ATGTTT/GTGTTA`	2	--	us2k¹ ds500¹		1		NA	120

HapMap Linkage Disequilibrium report for CGB2 (49535130 - 49536495 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CGB2
3 CNVs: 67577 5109 32261

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CGB2 for disorders About MalaCards

CGB2 for disorders About GeneDecksing

OMIM gene information: 608824 OMIM disorders: --

Export disorders for CGB2 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CGB2 gene, integrated from 9 sources (see all 14):
(articles sorted by number of sources associating them with CGB2)

Utopia: connect your pdf to the dynamic
world of online information

The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PubMed id 6194155)^{1, 3} Policastro P....Boime I. (1983)
The evolution and genomic landscape of CGB1 and CGB2 genes. (PubMed id 17055150)^{1, 9} Hallast P....Laan M. (2007)
Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues. (PubMed id 18048458)² Rull K.... Laan M. (2008)
Expression of beta-subunit of HCG genes during normal and failed pregnancy. (PubMed id 16123088)² Rull K. and Laan M. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)² Gerhard D.S....Malek J. (2004)
The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)² Grimwood J.... Lucas S.M. (2004)
Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)¹ Strausberg R.L....Marra M.A. (2002)
The sequence of the human genome. (PubMed id 11181995)¹ Venter J.C.... Zhu X. (2001)
Expression of the human chorionic gonadotropin-beta gene cluster in human pituitaries and alternate use of exon 1. (PubMed id 8954017)¹ Dirnhofer S....Berger P. (1996)
Identification of the transcriptionally active genes of the chorionic gonadotropin beta gene cluster in vivo. (PubMed id 1371113)¹ Bo M. and Boime I. (1992)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 114336	HGNC: 16722	AceView: CGB5andCGB2	Ensembl:ENSG00000104818	euGenes: HUgn114336
ECgene: CGB2	H-InvDB: CGB2

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CGB2	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CGB2 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CGB2 gene:
Search GeneIP for patents involving CGB2

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
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About This Section


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Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CGB2

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

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Category			VWF (GIFTS: 73) von Willebrand factor
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

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CGB2 Gene

chorionic gonadotropin, beta polypeptide 2

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CGB2 Gene

chorionic gonadotropin, beta polypeptide 2

Aliasesfor CGB2 gene

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for CGB2 gene

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for CGB2 gene

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