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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CGB1 Gene

protein-coding   GIFtS: 38
GCID: GC19M049538

Chorionic Gonadotropin, Beta Polypeptide 1

  Search for CGB1
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chorionic Gonadotropin, Beta Polypeptide 11 2
Choriogonadotropin Subunit Beta Variant 12

External Ids:    HGNC: 167211   Entrez Gene: 1143352   Ensembl: ENSG000002676317   OMIM: 6088235   UniProtKB: A6NKQ93   

Export aliases for CGB1 gene to outside databases

Previous GC identifers: GC19M050185 GC19M049895 GC19M054203 GC19M054219 GC19M054230 GC19M054224 GC19M045915


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CGB1 Gene:
The beta subunit of chorionic gonadotropin (CGB) is encoded by six highly homologous and structurally similar
genes that are arranged in tandem and inverted pairs on chromosome 19q13.3, and contiguous with the luteinizing
hormone beta (LHB) subunit gene. The CGB genes are primarily distinguished by differences in the 5' untranscribed
region. This gene was originally thought to be one of the two pseudogenes (CGB1 and CGB2) of CGB subunit,
however, detection of CGB1 and CGB2 transcripts in vivo, and their presence on the polysomes, suggested that
these transcripts are translated. To date, a protein product corresponding to CGB1 has not been isolated. The
deduced sequence of the hypothetical protein of 132 aa does not share any similarity with that of functional CGB
subunits (PMID:8954017). However, a 155 aa protein, translated from a different frame, is about the same size,
and shares 98% identity with other CGB subunits. (provided by RefSeq, Jul 2008)

GeneCards Summary for CGB1 Gene: 
CGB1 (chorionic gonadotropin, beta polypeptide 1) is a protein-coding gene. GO annotations related to this gene include hormone activity. An important paralog of this gene is TSHB.

Gene Wiki entry for CGB1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CGB1 gene promoter:
         AhR   NF-1   NF-1/L   Pax-5   Egr-4   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCGB1 promoter sequence
   Search SABiosciences Chromatin IP Primers for CGB1

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CGB1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.32

CGB1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CGB1 gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049538:  view genomic region     (about GC identifiers)

Start:
49,538,826 bp from pter      End:
49,552,006 bp from pter
Size:
13,181 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CGB1_HUMAN, A6NKQ9 (See protein sequence)
Recommended Name: Choriogonadotropin subunit beta variant 1 precursor  
Size: 187 amino acids; 20468 Da
Subcellular location: Secreted
Secondary accessions: A4FVC8 A8MUK6
Alternative splicing: 2 isoforms:  A6NKQ9-1   A6NKQ9-2   

Explore the universe of human proteins at neXtProt for CGB1: NX_A6NKQ9

Explore proteomics data for CGB1 at MOPED 

CGB1 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

CGB1 Protein Expression

REFSEQ proteins: NP_203695.2  
ENSEMBL proteins: 
 ENSP00000301407   ENSP00000472896   ENSP00000375742  

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Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005576extracellular region IEA--

CGB1 for ontologies           About GeneDecksing



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(According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section
3 InterPro protein domains:
 IPR018245 Gonadotropin_bsu_CS
 IPR001545 Gonadotropin_bsu
 IPR006208 Cys_knot

Graphical View of Domain Structure for InterPro Entry A6NKQ9

ProtoNet protein and cluster: A6NKQ9

UniProtKB/Swiss-Prot: CGB1_HUMAN, A6NKQ9
Similarity: Belongs to the glycoprotein hormones subunit beta family


CGB1 for domains           About GeneDecksing


(According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
About This Section

     Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

GO IDQualified GO termEvidencePubMed IDs
GO:0005179hormone activity IEA--
     
CGB1 for ontologies           About GeneDecksing


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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
About This Section



Interactions:

    Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CGB1

STRING Interaction Network Preview (showing 1 interactants - click image to see more details)

1 Interacting protein for CGB1 (ENSP000003014074) via UniProtKB, MINT, STRING, and/or I2D
InteractantInteraction Details
GeneCardExternal ID(s)
CGAENSP000003585954STRING: ENSP00000358595
About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section
Browse Small Molecules at EMD Millipore
Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CGB1

Search CenterWatch for drugs/clinical trials and news about CGB1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CGB1 gene: 
NM_033377.1  

Unigene Cluster for CGB1:

Chorionic gonadotropin, beta polypeptide 1
Hs.659014  [show with all ESTs]
Unigene Representative Sequence: BX334904
3 Ensembl transcripts including schematic representations, and UCSC links where relevant:
ENST00000301407(uc002plx.3) ENST00000601167 ENST00000391869
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  QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CGB1

Additional mRNA sequence: 

BC107144.1 BC126460.1 

6 DOTS entries:

DT.119691  DT.97797965  DT.100837633  DT.100044715  DT.121475007  DT.101971461 

24/409 AceView cDNA sequences (see all 409):

CF527874 BU752304 BM977377 CF527834 NM_033142 CR593396 T50278 BQ007403 
BU752823 CF528062 CF528337 AU138071 BQ007360 CF527771 CF528240 NM_000737 
BX359929 CF527932 CF527846 AA330859 CF528202 AI188689 CF527795 NM_033377 

GeneLoc Exon Structure


(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
See probesets specificity/sensitivity at GeneAnnot
CGAP TAG: --


See CGB1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CGB1

SOURCE GeneReport for Unigene cluster: Hs.659014

UniProtKB/Swiss-Prot: CGB1_HUMAN, A6NKQ9
Tissue specificity: Expressed in placenta, testis and pituitary

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In Situ
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Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGB1

(Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CGB1 gene from 3/8 species (see all 8)    About this table
Organism Taxonomic
classification
Gene Description Human
Similarity
Orthology
Type
Details
lizard
(Anolis carolinensis)
Reptilia --
Uncharacterized protein
38(a)
1 → many
6(80158039-80158659)
zebrafish
(Danio rerio)
Actinopterygii lhb6
luteinizing hormone, beta polypeptide
39(a)
1 → many
Zv9_scaffold3525(54871-57837)
fruit fly
(Drosophila melanogaster)
Insecta Gpb56
Glycoprotein hormone beta 5
14(a)
1 → many
2LHet(167215-167979)
        Species with no ortholog for CGB1

ENSEMBL Gene Tree for CGB1 (if available)
TreeFam Gene Tree for CGB1 (if available)

(Paralogs according to 1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
Paralogs for CGB1 gene
TSHB2  FSHB2  CGB22  LHB2  CGB82  ENSG000002673352  CGB52  CGB2  
CGB72  
8 SIMAP similar genes for CGB1 using alignment to 3 protein entries:     CGB1_HUMAN (see all proteins):
CGB    CGB5    CGB8    CGB2    CGB7    LHB
FSHB    TSHB

CGB1 for paralogs           About GeneDecksing



(SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

10/36 SNPs in CGB1 are shown (see all 36)    About this table     
Genomic DataTranscription Related DataAllele Frequencies
SNP IDValidClinical
significance
Chr 19 posSequence#AA
Chg
TypeMore#Allele
freq
PopTotal
sample
More
----------
VAR_0558384
----see VAR_0558382 P S mis40--------
rs711790761,2
C--49540499(-) ATCCC-/A/AA  
        
AAAAA
1 -- us2k11NA 2
rs1398805711,2
C--49540940(+) GCCTCA/GGAGGA 1 -- us2k10--------
rs1426438921,2
--49541489(+) GCTATG/TATTAT 1 -- us2k10--------
rs1886170061,2
--49541491(+) TATTAG/TTATTA 1 -- us2k10--------
rs1510216251,2
--49541564(+) CCACAC/TTGTTG 1 -- us2k10--------
rs1929215831,2
--49541638(+) TTCCCA/CAACTG 1 -- us2k10--------
rs1444515791,2
--49541650(+) GGTCCA/GTCCGT 1 -- us2k10--------
rs1416214581,2
C,F--49541825(+) ATCAGT/CGGTCA 1 -- us2k11Minor allele frequency- C:0.03EU 520
rs1381204491,2
--49541877(+) CAGTGC/TCCCCC 1 -- us2k10--------

HapMap Linkage Disequilibrium report for CGB1 (49538826 - 49552006 bp)

Structural Variations
     Database of Genomic Variants (DGV) 10 variations for CGB1:    About this table     
Variant IDTypeSubtypePubMed ID
esv2718698CNV Deletion23290073
nsv833859CNV Loss17160897
nsv912248CNV Loss21882294
nsv833857CNV Loss17160897
nsv912251CNV Loss21882294
dgv3970n71CNV Loss21882294
nsv912252CNV Loss21882294
dgv592n67CNV Loss20364138
esv22462CNV Gain19812545
nsv9739CNV Gain+Loss18304495

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CGB1 for disorders           About MalaCards
OMIM gene information: 608823    OMIM disorders: --


CGB1 for disorders           About GeneDecksing


Export disorders for CGB1 gene to outside databases

(in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
About This Section

PubMed articles for CGB1 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with CGB1)
    Utopia: connect your pdf to the dynamic
world of online information

  1. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PubMed id 6194155)1, 3 Policastro P....Boime I. (1983)
  2. The evolution and genomic landscape of CGB1 and CGB2 genes. (PubMed id 17055150)1, 9 Hallast P....Laan M. (2007)
  3. Analysis of the human CGB/LHB gene cluster in breast tumors by real-time quantitative RT-PCR assays. (PubMed id 11368883)1, 9 Giovangrandi Y....Bieche I. (2001)
  4. Human Chorionic Gonadotropin Beta Subunit Genes CGB1 a nd CGB2 are Transcriptionally Active in Ovarian Cancer. (PubMed id 23774837)1 Kubiczak M....Jankowska A. (2013)
  5. Fine-scale quantification of HCG beta gene transcription in human trophoblastic and non-malignant non-trophoblastic tissues. (PubMed id 18048458)2 Rull K.... Laan M. (2008)
  6. Expression of beta-subunit of HCG genes during normal and failed pregnancy. (PubMed id 16123088)2 Rull K. and Laan M. (2005)
  7. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)
  8. The DNA sequence and biology of human chromosome 19. (PubMed id 15057824)2 Grimwood J.... Lucas S.M. (2004)
  9. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PubMed id 12477932)1 Strausberg R.L....Marra M.A. (2002)
  10. The sequence of the human genome. (PubMed id 11181995)1 Venter J.C.... Zhu X. (2001)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section
 ANDOR
Aliases
Free Text  

  Query String
PubMed
OMIM
NCBI Bookshelf
  (Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section
Entrez Gene: 114335 HGNC: 16721 AceView: CGB_ Ensembl:ENSG00000267631 euGenes: HUgn114335
ECgene: CGB1 H-InvDB: CGB1

(According to HUGE)
About This Section
  --

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
NameDescription
PharmGKB entry for CGB1 Pharmacogenomics, SNPs, Pathways

(Patent information from GeneIP,
Licensable technologies from WIS Yeda, Salk, Tufts,
IP news from LifeMap Sciences, Inc.)
About This Section
Patent Information for CGB1 gene:
Search GeneIP for patents involving CGB1

GeneCards and IP:
Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
About This Section

 
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GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 4 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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transforming growth factor, beta 1
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The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z 


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