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Aliases for CGB Gene

Aliases for CGB Gene

  • Chorionic Gonadotropin, Beta Polypeptide 2 3
  • Chorionic Gonadotrophin Chain Beta 3 4
  • CG-Beta 3 4
  • CGB3 3 4
  • Chorionic Gonadotropin Beta 3 Subunit 3
  • Chorionic Gonadotropin Beta Subunit 3
  • Chorionic Gonadotropin Beta Chain 3
  • Choriogonadotropin Subunit Beta 3
  • CGB CGB5 CGB7 CGB8 4
  • CGB5 3
  • CGB7 3
  • CGB8 3
  • HCGB 3

External Ids for CGB Gene

Previous GeneCards Identifiers for CGB Gene

  • GC19M050184
  • GC19M049894
  • GC19M054202
  • GC19M054218
  • GC19M054222
  • GC19M054223
  • GC19M049526
  • GC19M045902

Summaries for CGB Gene

Entrez Gene Summary for CGB Gene

  • This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CGB Gene

CGB (Chorionic Gonadotropin, Beta Polypeptide) is a Protein Coding gene. Diseases associated with CGB include sarcomatoid renal cell carcinoma and ectopic pregnancy. Among its related pathways are Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein and Peptide hormone metabolism. GO annotations related to this gene include hormone activity. An important paralog of this gene is TSHB.

UniProtKB/Swiss-Prot for CGB Gene

  • Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

Gene Wiki entry for CGB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGB Gene

Genomics for CGB Gene

Regulatory Elements for CGB Gene

Genomic Location for CGB Gene

Start:
49,022,869 bp from pter
End:
49,024,375 bp from pter
Size:
1,507 bases
Orientation:
Minus strand

Genomic View for CGB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGB Gene

Proteins for CGB Gene

  • Protein details for CGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01233-CGHB_HUMAN
    Recommended name:
    Choriogonadotropin subunit beta
    Protein Accession:
    P01233
    Secondary Accessions:
    • A1A5E0
    • B9ZVP5
    • Q13991
    • Q14000
    • Q3KPI3
    • Q3SY41
    • Q8WTT5
    • Q8WXL1
    • Q8WXL2
    • Q8WXL3
    • Q8WXL4

    Protein attributes for CGB Gene

    Size:
    165 amino acids
    Molecular mass:
    17739 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin
    SequenceCaution:
    • Sequence=CAA25068.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA25069.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CGB Gene

    Alternative splice isoforms for CGB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CGB Gene

Proteomics data for CGB Gene at MOPED

Post-translational modifications for CGB Gene

  • Glycosylation at Asn33, Asn50, Ser141, Ser147, Ser152, and Ser158
  • Modification sites at PhosphoSitePlus

Other Protein References for CGB Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CGB Gene

Domains for CGB Gene

Gene Families for CGB Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

P01233

UniProtKB/Swiss-Prot:

CGHB_HUMAN :
  • P01233
Family:
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with CGB: view

No data available for Suggested Antigen Peptide Sequences for CGB Gene

Function for CGB Gene

Molecular function for CGB Gene

GENATLAS Biochemistry: chorionic gonadotropin,beta subunit,including in a cluster (made of 6 genes and like-sequences and LHB)
UniProtKB/Swiss-Prot Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

Gene Ontology (GO) - Molecular Function for CGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IMP 11207219
genes like me logo Genes that share ontologies with CGB: view

miRNA Products

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CGB Gene

Localization for CGB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGB Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CGB Gene COMPARTMENTS Subcellular localization image for CGB gene
Compartment Confidence
extracellular 5
cytosol 3
endoplasmic reticulum 1
nucleus 1
peroxisome 1

Gene Ontology (GO) - Cellular Components for CGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with CGB: view

Pathways for CGB Gene

genes like me logo Genes that share pathways with CGB: view

Pathways by source for CGB Gene

Gene Ontology (GO) - Biological Process for CGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 7723844
GO:0007165 signal transduction TAS 10468638
GO:0007267 cell-cell signaling TAS 6194155
GO:0007292 female gamete generation TAS 10468638
GO:0016486 peptide hormone processing TAS --
genes like me logo Genes that share ontologies with CGB: view

Compounds for CGB Gene

UniProtKB/Swiss-Prot:

P01233-CGHB_HUMAN
Pharmaceutical: Available under the names Novarel (Ferring) and Profasi (Serono). Used as adjunctive therapy in the treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting from caloric restriction, that it causes a more attractive or normal distribution of fat, or that it decreases the hunger and discomfort associated with calorie-restricted diets

(28) Novoseek inferred chemical compound relationships for CGB Gene

Compound -log(P) Hits PubMed IDs
methotrexate 62.6 12
etoposide 52.9 2
bleomycin 49.4 1
ctp 48.7 5
progesterone 45.2 38
genes like me logo Genes that share compounds with CGB: view

Transcripts for CGB Gene

mRNA/cDNA for CGB Gene

(247) Selected AceView cDNA sequences:
(9) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CGB Gene

Chorionic gonadotropin, beta polypeptide:
Representative Sequences:

miRNA Products

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CGB
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CGB Gene

No ASD Table

Relevant External Links for CGB Gene

GeneLoc Exon Structure for
CGB
ECgene alternative splicing isoforms for
CGB

Expression for CGB Gene

mRNA expression in normal human tissues for CGB Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CGB Gene

This gene is overexpressed in Testis (17.9), Pancreas (14.8), and Pituitary (7.6).

SOURCE GeneReport for Unigene cluster for CGB Gene Hs.446683

mRNA Expression by UniProt/SwissProt for CGB Gene

P01233-CGHB_HUMAN
Tissue specificity: Placenta
genes like me logo Genes that share expressions with CGB: view

In Situ Assay Products

No data available for Protein expression for CGB Gene

Orthologs for CGB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGB Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
cow
(Bos Taurus)
Mammalia LHB 36
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LHB 36
  • 64 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Lhb 36
  • 62 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia LHB 36
  • 55 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii lhb 36
  • 39 (a)
OneToMany
Species with no ortholog for CGB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGB Gene

ENSEMBL:
Gene Tree for CGB (if available)
TreeFam:
Gene Tree for CGB (if available)

Paralogs for CGB Gene

Paralogs for CGB Gene

Selected SIMAP similar genes for CGB Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CGB: view

Variants for CGB Gene

Sequence variations from dbSNP and Humsavar for CGB Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2387592 -- 49,026,147(+) CTGGG(A/G)TTAGA upstream-variant-2KB
rs3956234 -- 49,023,708(+) CTTCC(C/T)GGCAT intron-variant, utr-variant-5-prime
rs4002421 -- 49,023,797(-) GATCT(A/G)AAATG intron-variant, upstream-variant-2KB
rs4002463 -- 49,022,862(+) ACACC(G/T)CCAGA downstream-variant-500B
rs4002465 -- 49,023,804(+) GATCC(A/C/G/T)CACCT intron-variant, upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CGB Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833857 CNV Loss 17160897
nsv912248 CNV Loss 21882294
dgv3970n71 CNV Loss 21882294
nsv833859 CNV Loss 17160897
nsv912251 CNV Loss 21882294
esv22462 CNV Gain 19812545
nsv912252 CNV Loss 21882294

Relevant External Links for CGB Gene

HapMap Linkage Disequilibrium report
CGB
Human Gene Mutation Database (HGMD)
CGB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGB Gene

Disorders for CGB Gene

(1) University of Copenhagen DISEASES for CGB Gene

(82) Novoseek inferred disease relationships for CGB Gene

Disease -log(P) Hits PubMed IDs
pregnancy ectopic 82.4 31
down syndrome 82.1 72
germinoma 80.3 9
choriocarcinoma 79.6 6
hydatidiform mole 79.2 8

Relevant External Links for CGB

Genetic Association Database (GAD)
CGB
Human Genome Epidemiology (HuGE) Navigator
CGB
genes like me logo Genes that share disorders with CGB: view

No data available for UniProtKB/Swiss-Prot for CGB Gene

Publications for CGB Gene

  1. Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form. (PMID: 1688430) Saccuzo Beebe J. … Ruddon R.W. (J. Biol. Chem. 1990) 3 4 23
  2. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PMID: 6194155) Policastro P. … Boime I. (J. Biol. Chem. 1983) 2 3 4
  3. The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region. (PMID: 6774259) Fiddes J.C. … Goodman H.M. (Nature 1980) 2 3 4
  4. Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. (PMID: 6690982) Talmadge K. … Fiddes J.C. (Nature 1984) 3 4
  5. Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection. (PMID: 11861891) Maston G.A. … Ruvolo M. (Mol. Biol. Evol. 2002) 3 4

Products for CGB Gene

  • Addgene plasmids for CGB

Sources for CGB Gene

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