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Aliases for CGB Gene

Aliases for CGB Gene

  • Chorionic Gonadotropin, Beta Polypeptide 2 3
  • Chorionic Gonadotrophin Chain Beta 3 4
  • CG-Beta 3 4
  • CGB3 3 4
  • Chorionic Gonadotropin Beta 3 Subunit 3
  • Chorionic Gonadotropin Beta Subunit 3
  • Chorionic Gonadotropin Beta Chain 3
  • CGB CGB5 CGB7 CGB8 4
  • HCGB 3
  • CGB5 3
  • CGB7 3
  • CGB8 3

External Ids for CGB Gene

Previous GeneCards Identifiers for CGB Gene

  • GC19M050184
  • GC19M049894
  • GC19M054202
  • GC19M054218
  • GC19M054222
  • GC19M054223
  • GC19M049526
  • GC19M045902

Summaries for CGB Gene

Entrez Gene Summary for CGB Gene

  • This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the luteinizing hormone beta subunit gene. [provided by RefSeq, Jul 2008]

GeneCards Summary for CGB Gene

CGB (Chorionic Gonadotropin, Beta Polypeptide) is a Protein Coding gene. Diseases associated with CGB include tuberculous epididymitis and ectopic pregnancy. Among its related pathways are Transport to the Golgi and subsequent modification and Peptide hormone metabolism. GO annotations related to this gene include hormone activity. An important paralog of this gene is TSHB.

UniProtKB/Swiss-Prot for CGB Gene

  • Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

Gene Wiki entry for CGB Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGB Gene

Genomics for CGB Gene

Regulatory Elements for CGB Gene

Genomic Location for CGB Gene

Chromosome:
19
Start:
49,022,869 bp from pter
End:
49,024,375 bp from pter
Size:
1,507 bases
Orientation:
Minus strand

Genomic View for CGB Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CGB Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGB Gene

Proteins for CGB Gene

  • Protein details for CGB Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01233-CGHB_HUMAN
    Recommended name:
    Choriogonadotropin subunit beta
    Protein Accession:
    P01233
    Secondary Accessions:
    • A1A5E0
    • B9ZVP5
    • Q13991
    • Q14000
    • Q3KPI3
    • Q3SY41
    • Q8WTT5
    • Q8WXL1
    • Q8WXL2
    • Q8WXL3
    • Q8WXL4

    Protein attributes for CGB Gene

    Size:
    165 amino acids
    Molecular mass:
    17739 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin
    SequenceCaution:
    • Sequence=CAA25068.1; Type=Erroneous initiation; Evidence={ECO:0000305}; Sequence=CAA25069.1; Type=Erroneous initiation; Evidence={ECO:0000305};

    Three dimensional structures from OCA and Proteopedia for CGB Gene

    Alternative splice isoforms for CGB Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CGB Gene

Proteomics data for CGB Gene at MOPED

Post-translational modifications for CGB Gene

  • Glycosylation at Asn 33, Asn 50, Ser 141, Ser 147, Ser 152, and Ser 158
  • Modification sites at PhosphoSitePlus

Other Protein References for CGB Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CGB Gene

Domains & Families for CGB Gene

Graphical View of Domain Structure for InterPro Entry

P01233

UniProtKB/Swiss-Prot:

CGHB_HUMAN :
  • Belongs to the glycoprotein hormones subunit beta family.
Family:
  • Belongs to the glycoprotein hormones subunit beta family.
genes like me logo Genes that share domains with CGB: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CGB Gene

Function for CGB Gene

Molecular function for CGB Gene

GENATLAS Biochemistry:
chorionic gonadotropin,beta subunit,including in a cluster (made of 6 genes and like-sequences and LHB)
UniProtKB/Swiss-Prot Function:
Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

Gene Ontology (GO) - Molecular Function for CGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IMP 11207219
genes like me logo Genes that share ontologies with CGB: view
genes like me logo Genes that share phenotypes with CGB: view

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CGB

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CGB Gene

Localization for CGB Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGB Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CGB Gene COMPARTMENTS Subcellular localization image for CGB gene
Compartment Confidence
extracellular 5
golgi apparatus 2
cytosol 1
endoplasmic reticulum 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with CGB: view

Pathways & Interactions for CGB Gene

genes like me logo Genes that share pathways with CGB: view

Pathways by source for CGB Gene

Gene Ontology (GO) - Biological Process for CGB Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006915 apoptotic process TAS 7723844
GO:0007165 signal transduction TAS 10468638
GO:0007267 cell-cell signaling TAS 6194155
GO:0007292 female gamete generation TAS 10468638
GO:0016486 peptide hormone processing TAS --
genes like me logo Genes that share ontologies with CGB: view

No data available for SIGNOR curated interactions for CGB Gene

Drugs & Compounds for CGB Gene

(21) Drugs for CGB Gene - From: NovoSeek and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Bleomycin Approved Pharma 142
Cisplatin Approved Pharma Inhibits DNA synthesis,chemotherapy drug, Platinum, Potent pro-apoptotic anticancer agent; activates caspase-3 2437
Cyclophosphamide Approved, Investigational Pharma Nitrogen mustard alkylating agent and prodrug. 2525
Estradiol Approved, Investigational Pharma Sex hormone 1057
Etoposide Approved Pharma Topo II inhibitor, Topoisomerase 2 Inhibitors, Topoisomerase II inhibitor 1127

(8) Additional Compounds for CGB Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Creatinine
  • 1-Methylglycocyamidine
  • 1-Methylhydantoin-2-imide
  • 2-Amino-1-methyl-1,5-dihydroimidazol-4-one
  • 2-Amino-1-methylimidazolin-4-one
  • Creatine anhydride
60-27-5
ctp
glucose
GnRH
lactate
genes like me logo Genes that share compounds with CGB: view

Transcripts for CGB Gene

mRNA/cDNA for CGB Gene

(1) REFSEQ mRNAs :
(9) Additional mRNA sequences :
(247) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CGB Gene

Chorionic gonadotropin, beta polypeptide:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CGB

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CGB Gene

No ASD Table

Relevant External Links for CGB Gene

GeneLoc Exon Structure for
CGB
ECgene alternative splicing isoforms for
CGB

Expression for CGB Gene

mRNA expression in normal human tissues for CGB Gene

mRNA differential expression in normal tissues according to GTEx for CGB Gene

This gene is overexpressed in Testis (x17.9), Pancreas (x14.8), and Pituitary (x7.6).

SOURCE GeneReport for Unigene cluster for CGB Gene Hs.446683

mRNA Expression by UniProt/SwissProt for CGB Gene

P01233-CGHB_HUMAN
Tissue specificity: Placenta
genes like me logo Genes that share expression patterns with CGB: view

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for Protein differential expression in normal tissues , Protein expression and Protein tissue co-expression partners for CGB Gene

Orthologs for CGB Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGB Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia LHB 36
  • 65 (a)
OneToMany
dog
(Canis familiaris)
Mammalia LHB 36
  • 64 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia LHB 36
  • 55 (a)
OneToMany
mouse
(Mus musculus)
Mammalia Lhb 36
  • 62 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 97 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 36 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii lhb 36
  • 39 (a)
OneToMany
Species with no ortholog for CGB:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGB Gene

ENSEMBL:
Gene Tree for CGB (if available)
TreeFam:
Gene Tree for CGB (if available)

Paralogs for CGB Gene

Paralogs for CGB Gene

(7) SIMAP similar genes for CGB Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CGB: view

Variants for CGB Gene

Sequence variations from dbSNP and Humsavar for CGB Gene

SNP ID Clin Chr 19 pos Sequence Context AA Info Type MAF
rs2387592 -- 49,026,147(+) CTGGG(A/G)TTAGA upstream-variant-2KB
rs3956234 -- 49,023,708(+) CTTCC(C/T)GGCAT intron-variant
rs4002421 -- 49,023,797(-) GATCT(A/G)AAATG intron-variant
rs4002463 -- 49,022,862(+) ACACC(G/T)CCAGA downstream-variant-500B
rs4002465 -- 49,023,804(+) GATCC(A/C/G/T)CACCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CGB Gene

Variant ID Type Subtype PubMed ID
nsv9739 CNV Gain+Loss 18304495
nsv833857 CNV Loss 17160897
nsv912248 CNV Loss 21882294
dgv3970n71 CNV Loss 21882294
nsv833859 CNV Loss 17160897
nsv912251 CNV Loss 21882294
esv22462 CNV Gain 19812545
nsv912252 CNV Loss 21882294

Variation tolerance for CGB Gene

Gene Damage Index Score: 0.32; 7.17% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CGB Gene

HapMap Linkage Disequilibrium report
CGB
Human Gene Mutation Database (HGMD)
CGB

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGB Gene

Disorders for CGB Gene

MalaCards: The human disease database

(27) MalaCards diseases for CGB Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
tuberculous epididymitis
  • tuberculosis of epididymis
ectopic pregnancy
  • eccyesis
testicular leydig cell tumor
  • testicular leydig cell neoplasm
placental site trophoblastic tumor
  • placental-site gestational trophoblastic neoplasm
extragonadal germ cell tumor
- elite association
Search CGB in MalaCards View complete list of genes associated with diseases

Relevant External Links for CGB

Genetic Association Database (GAD)
CGB
Human Genome Epidemiology (HuGE) Navigator
CGB
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CGB
genes like me logo Genes that share disorders with CGB: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CGB Gene

Publications for CGB Gene

  1. New advances in clinical biomarkers in testis cancer. (PMID: 20036893) Favilla V. … Morgia G. (Front Biosci (Elite Ed) 2010) 23 67
  2. [A case of sertoli cell tumor with arteriovenous malformation]. (PMID: 20104012) Sasaki M. … Ota S. (Hinyokika Kiyo 2010) 23 67
  3. Positive pregnancy tests in a postmenopausal woman due to beta-human chorionic gonadotropin production by multiple myeloma. (PMID: 20145436) Tageja N. … Zonder J. (Am. J. Med. Sci. 2010) 23 67
  4. The diagnostic value of beta-human chorionic gonadotropin, progesterone, CA125 in the prediction of abortions. (PMID: 20373934) OsmanaA9aoA9lu M.A. … Bozkaya H. (J Obstet Gynaecol 2010) 23 67
  5. Are early human chorionic gonadotropin levels after methotrexate therapy a predictor of response in ectopic pregnancy? (PMID: 20510964) Nguyen Q. … Silva C. (Am. J. Obstet. Gynecol. 2010) 23 67

Products for CGB Gene

  • Addgene plasmids for CGB

Sources for CGB Gene

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