Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CGB Gene

protein-coding GIFtS: 60
GCID: GC19M049526

chorionic gonadotropin, beta polypeptide

Explore 114 diseases affiliated with
CGB via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Chorionic Gonadotropin, Beta Polypeptide¹ ²		CGB8²
CGB3¹ ² ³		Choriogonadotropin Subunit Beta²
Chorionic Gonadotrophin Chain Beta² ³		Chorionic Gonadotropin Beta 3 Subunit²
CG-Beta¹		Chorionic Gonadotropin Beta Chain²
CGB5²		Chorionic Gonadotropin Beta Subunit²
CGB7²		HCGB¹

External Ids:	HGNC: 1886¹	Entrez Gene: 1082²	Ensembl: ENSG00000104827⁷	OMIM: 118860⁵	UniProtKB: P01233³

Export aliases for CGB gene to outside databases

Previous GC identifers: GC19M050184 GC19M049894 GC19M054202 GC19M054218 GC19M054222 GC19M054223 GC19M045902

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CGB:

This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic

gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta

subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and stimulates

the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta subunit of CG is

encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and contiguous with the

luteinizing hormone beta subunit gene. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233

Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

Gene Wiki entry for CGB (Chorionic gonadotropin beta)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000019.9 NC_018930.1 NT_011109.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CGB gene promoter:
AhR NF-1 NF-1/L Pax-5 POU3F1 GATA-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CGB promoter sequence

Search SABiosciences Chromatin IP Primers for CGB

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CGB

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32 Ensembl cytogenetic band: 19q13.33 HGNC cytogenetic band: 19q13.3

CGB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CGB gene location

GeneLoc information about chromosome 19 GeneLoc Exon Structure

GeneLoc location for GC19M049526: view genomic region (about GC identifiers)

Start:	49,526,127 bp from pter	End:	49,527,593 bp from pter
Size:	1,467 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233 (See protein sequence)

Recommended Name: Choriogonadotropin subunit beta precursor

Size: 165 amino acids; 17739 Da

Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to

thyrotropin, lutropin, follitropin and gonadotropin

Subcellular location: Secreted

Developmental stage: Made by the first trimester placenta

Sequence caution: Sequence=CAA25068.1; Type=Erroneous initiation; Sequence=CAA25069.1; Type=Erroneous initiation;

4 PDB 3D structures from and Proteopedia for CGB:

1HCN (3D)

1HRP (3D)

1QFW (3D)

1XUL (3D)

Secondary accessions: A1A5E0 B9ZVP5 Q13991 Q14000 Q3KPI3 Q3SY41 Q8WTT5 Q8WXL1 Q8WXL2 Q8WXL3 Q8WXL4

Alternative splicing: 2 isoforms: P01233-1 P01233-2 (Ref.2 (CAA25069) sequence is in conflict in positions: 7:G->R, 9:A->V, 12:D->G)

Explore the universe of human proteins at neXtProt for CGB: NX_P01233

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P01233

CGB Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_000728.1

ENSEMBL proteins:

ENSP00000349954

Reactome Protein details: P01233
Human Recombinant Protein Products for CGB:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CGB (Chorionic Gonadotropin alpha/beta (HCG))
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells Browse OriGene Protein Over-expression Lysates OriGene Custom Protein Services for CGB
	GenScript Custom Purified and Recombinant Proteins Services for CGB
	Novus Biologicals CGB Proteins Novus Biologicals CGB Lysate
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005625	soluble fraction	--	--

CGB for ontologies About GeneDecksing

CGB Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CGB
	Browse R&D Systems for Antibodies
	OriGene Antibodies: CGB OriGene Custom Antibody Services for CGB
	GenScript Custom Superior Antibodies Services for CGB
	Novus Biologicals CGB Antibodies
	Abcam antibodies for CGB
	Browse Antibodies at Uscn
	ThermoFisher Antibody for CGB

Assay Products for CGB:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CGB
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CGB for domains About GeneDecksing

3 InterPro domains/families:

IPR018245 Gonadotropin_bsu_CS

IPR001545 Gonadotropin_bsu

IPR006208 Cys_knot

Graphical View of Domain Structure for InterPro Entry P01233

ProtoNet protein and cluster: P01233

3 Blocks protein families:

IPB001545 Gonadotropin

IPB002400 Growth factor cystine knot superfamily signature

IPB006208 Cystine knot domain

UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233

Similarity: Belongs to the glycoprotein hormones subunit beta family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CGHB_HUMAN, P01233

Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

Genatlas biochemistry entry for CGB:

chorionic gonadotropin,beta subunit,including in a cluster (made of 6 genes and like-sequences and LHB)

Gene Ontology (GO): 1 molecular function term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	IEA	--

CGB for ontologies About GeneDecksing

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CGB

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CGB
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CGB
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CGB OriGene shRNA RFP: CGB OriGene siRNA: CGB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CGB
		Sirion Biotech Custom design and validation of potent shRNA sequences against CGB

Gene Editing Products:			DNA2.0 Custom Protein Engineering Service for CGB
			Sirion Biotech Customized adenovirus for overexpression of CGB Sirion Biotech Customized adenovirus for potent knockdown of CGB

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CGB OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CGB OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CGB (NM_000737)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CGB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CGB

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CGB
		Search LifeMap BioReagents cell lines for CGB
		Sirion Biotech Customized stable knockdown cell line services for CGB Sirion Biotech Customized inducible knockdown cell line services for CGB Sirion Biotech Customized stable overexpressing cell line services for CGB Sirion Biotech Customized inducible overexpressing cell line services for CGB

In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CGB

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glycoprotein hormones

Glycoprotein hormones

1.00

Peptide hormone biosynthesis

0.71

Selected targets of Oct-3/4

Selected targets of Oct-3/4

1.00

Insulin Processing

Peptide hormone metabolism

0.39

Asparagine N-linked glycosylation

Metabolism of proteins

0.15

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CGB

Selected targets of Oct-3/4

4 Reactome Pathways for CGB

	Peptide hormone biosynthesis
	Metabolism of proteins
	Glycoprotein hormones
	Peptide hormone metabolism

CGB for pathways About GeneDecksing

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CGB

STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

5 Interacting proteins for CGB (P01233^{2, 3} ENSP00000349954⁴) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CGA	P01215²^,³, ENSP00000358595⁴	MINT-24926 I2D: score=5 STRING: ENSP00000358595
LHCGR	P22888³, ENSP00000294954⁴	I2D: score=1 STRING: ENSP00000294954
FSHB	P01225³, ENSP00000254122⁴	I2D: score=1 STRING: ENSP00000254122
CKB	P12277³	I2D: score=1
EWSR1	Q01844³	I2D: score=1

About this table

Gene Ontology (GO): 5/7 biological process terms (GO ID links to tree view) (see all 7): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006915	apoptotic process	TAS	7723844
GO:0007165	signal transduction	TAS	10468638
GO:0007267	cell-cell signaling	TAS	6194155
GO:0007292	female gamete generation	TAS	10468638
GO:0016486	peptide hormone processing	TAS	--

CGB for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CGB for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CGB
UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233

Pharmaceutical: Available under the names Novarel (Ferring) and Profasi (Serono). Used as adjunctive therapy in the

treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting from

caloric restriction, that it causes a more attractive or 'normal' distribution of fat, or that it decreases the hunger

and discomfort associated with calorie-restricted diets

10/28 Novoseek chemical compound relationships for CGB gene (see all 28) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
methotrexate	62.6	13	1377160 (2), 11172133 (1), 16036203 (1), 16519378 (1) (see all 11)
etoposide	52.9	2	12940324 (1), 18813353 (1)
bleomycin	49.4	1	18813353 (1)
ctp	48.7	5	20110752 (1), 16122898 (1), 17641000 (1), 9815634 (1) (see all 5)
progesterone	45.2	43	1377160 (4), 7520212 (4), 19802539 (2), 15188764 (2) (see all 27)
ifosfamide	41	1	12940324 (1)
oestriol	36.9	2	7530437 (1), 9639764 (1)
estradiol	36.5	16	9926805 (1), 7520962 (1), 1702401 (1), 10322841 (1) (see all 15)
cisplatin	36.1	2	12940324 (1), 18813353 (1)
mifepristone	35.1	1	15188764 (1)

Search CenterWatch for drugs/clinical trials and news about CGB / CGHB

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CGB gene:

NM_000737.3

Unigene Clusters for CGB:

Chorionic gonadotropin, beta polypeptide

Hs.446683 [show with all ESTs], Hs.743279 [show with all ESTs]

Unigene Representative Sequences: NM_000737, BC030994

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000357383(uc002plv.2)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CGB
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CGB
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CGB OriGene shRNA RFP: CGB OriGene siRNA: CGB
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CGB
		Sirion Biotech Custom design and validation of potent shRNA sequences against CGB

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CGB OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CGB OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CGB (NM_000737)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CGB
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CGB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CGB Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat CGB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CGB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CGB

Additional cDNA sequence:

BC030994.1 BC069526.1 BC103969.1 BC128603.1

4 DOTS entries:

DT.119691 DT.100837633 DT.97797965 DT.121475036

24/247 AceView cDNA sequences (see all 247):

BC006290 BC069367 BC051378 AA330859 T50278 NM_033378 NM_033043 AA331012

CA944648 BQ011219 AA330413 BV199139 AI417614 CR597606 CF527786 CF528653

BX378649 BQ007392 BQ011244 BQ011275 BV206765 H93656 BX358522 AA330803

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CGB expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: ACCCGCGTGC

About this image

CGB expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 3 LifeMap Cells

Name

Category

Syncytiotrophoblast-like cells (Generation of syncyt...)

Trophoblast-like cells (Generation of tropho...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CGB Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CGB

SOURCE GeneReport for Unigene clusters: Hs.446683 Hs.743279

UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233

Tissue specificity: Placenta

SABiosciences Custom PCR Arrays for CGB

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CGB Browse OriGene validated miRNA SYBR primer pairs
		Search SABiosciences RT² qPCR Primer Assays in human, mouse, rat CGB
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CGB
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CGB

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CGB

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CGB gene from 2/6 species (see all 6) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	--	--	37(a)	1 → many	6(80158039-80158659)
zebrafish (Danio rerio)	Actinopterygii	lhb⁶	luteinizing hormone, beta polypeptide	40(a)	1 → many	Zv9_scaffold3525(54871-57837)

ENSEMBL Gene Tree for CGB (if available)
TreeFam Gene Tree for CGB (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CGB gene

CGB5¹ ² CGB8¹ ² TSHB² FSHB² CGB2² LHB² ENSG00000267335² CGB7²

CGB1²

7 SIMAP similar genes for CGB using alignment to 1 protein entry: CGHB_HUMAN:

CGB8 CGB2 CGB1 CGB7 LHB FSHB

TSHB

CGB for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 19 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs11333553^1,2	C,F	--	49525637(+)	`GACAAT/-TTTTT`	1	--	ds500¹		2		NA CSA	4
rs118157810^1,2	F	--	49525656(+)	`TGAGAC/TGGACT`	1	--	ds500¹		1		NA	120
rs186336209^1,2		--	49525765(+)	`GAGTAC/GCTGGG`	1	--	ds500¹		0	--	--	--	--
rs79417005^1,2	C,F	--	49525809(+)	`TCTTTA/GTGTAA`	1	--	ds500¹		3		WA CSA	122
rs190447675^1,2		--	49525827(+)	`AGAGAC/TGGGGT`	1	--	ds500¹		0	--	--	--	--
rs182525730^1,2		--	49525902(+)	`TCAAAC/GTGCTG`	1	--	ds500¹		0	--	--	--	--
rs186653116^1,2		--	49525993(+)	`GTTGCA/GATGTC`	1	--	ds500¹		0	--	--	--	--
rs143227819^1,2		--	49526005(+)	`TCCCCC/TGACCC`	1	--	ds500¹		0	--	--	--	--
rs192070879^1,2		--	49526008(+)	`CCCGAC/GCCCAC`	1	--	ds500¹		0	--	--	--	--
rs7256186^1,2	C	--	49526014(+)	`CCCACA/CCTGTT`	1	--	ds500¹		1		NA	2

HapMap Linkage Disequilibrium report for CGB (49526127 - 49527593 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 3 variations for CGB
3 CNVs: 67577 5109 32261
Human Gene Mutation Database (HGMD): CGB

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CGB

DNA2.0 Custom Variant and Variant Library Synthesis for CGB

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CGB for disorders           About GeneDecksing

OMIM gene information: 118860    OMIM disorders: --

20/114 diseases for CGB (see all 114):    About MalaCards

superior vena cava syndrome 46 xy gonadal dysgenesis growth hormone secreting pituitary adenoma neural tube defect

placental site trophoblastic tumor central nervous system germ cell tumor central nervous system germinoma lymphoepithelioma-like carcinoma

gonadal dysgenesis mixed ductal-endocrine carcinoma germ cell tumor ectopic pregnancy

nonseminomatous germ cell tumor extragonadal germ cell tumor fibrous histiocytoma testicular microlithiasis

testicular leydig cell tumor adrenal rest tumor malignant fibrous histiocytoma leydig cell tumor

1 disease from the University of Copenhagen DISEASES database for CGB:

Cryptococcosis

10/82 Novoseek disease relationships for CGB gene (see all 82) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
pregnancy ectopic	82.4	32	10577398 (2), 9166176 (2), 1534728 (1), 8745091 (1) (see all 29)
down syndrome	82.1	76	8623793 (5), 9396880 (4), 7485343 (3), 14981387 (3) (see all 54)
germinoma	80.3	9	16015498 (1), 16010454 (1), 17140187 (1), 17339149 (1) (see all 9)
choriocarcinoma	79.6	6	9639324 (2), 1723674 (1), 7514765 (1), 14628141 (1) (see all 5)
hydatidiform mole	79.2	8	19517692 (1), 15171312 (1), 9988795 (1), 19691261 (1) (see all 8)
pregnancy tubal ruptured	73.6	1	7514547 (1)
gestational trophoblastic disease	73.6	7	11759958 (2), 9988795 (1), 7518517 (1), 12876023 (1) (see all 6)
pregnancy tubal	73.4	4	16097977 (2), 7514547 (1), 12386356 (1)
seminoma	73	13	1372658 (3), 8394368 (2), 1711586 (1), 16033057 (1) (see all 8)
yolk sac tumor	67.3	3	7514765 (1), 19075540 (1), 15247758 (1)

Human Genome Epidemiology (HuGE) Navigator: CGB (3 documents)

Export disorders for CGB gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CGB gene, integrated from 9 sources (see all 585):
(articles sorted by number of sources associating them with CGB)

Utopia: connect your pdf to the dynamic
world of online information

The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PubMed id 6194155)^{1, 2, 3} Policastro P....Boime I. (1983)
The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region. (PubMed id 6774259)^{1, 2, 3} Fiddes J.C. and Goodman H.M. (1980)
Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form. (PubMed id 1688430)^{1, 2, 9} Saccuzo Beebe J.... Ruddon R.W. (1990)
Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection. (PubMed id 11861891)^{1, 2} Maston G.A. and Ruvolo M. (2002)
Crystal structure of human chorionic gonadotropin. (PubMed id 8202136)^{1, 2} Lapthorn A.J.... Isaacs N.W. (1994)
Site-specific N-glycosylation of human chorionic gonadotrophin -- structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy. (PubMed id 1820200)^{1, 2} Weisshaar G.... Renwick A.G.C. (1991)
A map of the hCG beta-LH beta gene cluster. (PubMed id 2422163)^{1, 2} Policastro P.F.... Boime I. (1986)
Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. (PubMed id 6690982)^{1, 2} Talmadge K.... Fiddes J.C. (1984)
Reduction of human chorionic gonadotropin beta subunit expression by modified U1 snRNA caused apoptosis in cervical cancer cells. (PubMed id 18339208)^{1, 9} Jankowska A....Warchol J.B. (2008)
Apoptosis and tumor inhibition induced by human chorionic gonadotropin beta in mouse breast carcinoma. (PubMed id 16924466)^{1, 9} Shi S.Q....Peng J.P. (2006)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1082	HGNC: 1886	AceView: CGB5andCGB2	Ensembl:ENSG00000104827	euGenes: HUgn1082
ECgene: CGB	H-InvDB: CGB

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CGB	Pharmacogenomics, SNPs, Pathways
Wikipedia	http://en.wikipedia.org/wiki/Human_chorionic_gonadotropin

Intellectual Property for CGB gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CGB gene:
Search GeneIP for patents involving CGB

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory)
About This Section

	Browse Small Molecules at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of CGB
	Browse Kits and Assays available from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Browse Antibodies		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for CGB (Chorionic Gonadotropin alpha/beta (HCG))

	OriGene Antibodies for CGB		OriGene shRNA RFP for CGB
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CGB		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CGB
	Browse OriGene Protein Over-expression Lysates		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CGB		Browse 3'-UTR reporter clones for miRNA target validation
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CGB		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CGB
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	Browse OriGene full length recombinant human proteins expressed in human HEK293 cells		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CGB		OriGene Custom Protein Services for CGB
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CGB
	QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CGB
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CGB
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CGB
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CGB
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CGB

	GenScript Custom Purified and Recombinant Proteins Services for CGB		GenScript cDNA clones with any tag delivered in your preferred vector for CGB
	GenScript Custom Assay Services for CGB		GenScript Custom Superior Antibodies Services for CGB
	GenScript Custom overexpressing Cell Line Services for CGB		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Search for Antibodies & Assays

	Regulatory tfbs in CGB promoter
	Search Chromatin IP Primers for CGB
	Search RT² qPCR Primer Assays in human, mouse, rat CGB
	Search GNC Networks for CGB
	SABiosciences Custom PCR Arrays for CGB

Search Tocris compounds for CGB

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CGB antibodies
	CGB proteins
	CGB lysates

	Antibodies for CGB
	See all of Abcam's Antibodies, Kits and Proteins for CGB
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Browse ProSpec Recombinant Proteins

Browse ELISAs, CLIAs, Proteins, and Antibodies at Uscn

Search LifeMap BioReagents cell lines for CGB

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CGB

	Browse SwitchGear 3'UTR luciferase reporter plasmids for CGB
	SwitchGear Promoter luciferase reporter plasmids for CGB

ThermoFisher Antibody for CGB

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CGB

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CGB

Sirion Biotech Customized:

	stable knockdown cell line services for CGB
	inducible knockdown cell line services for CGB
	design and validation of potent shRNA sequences against CGB
	adenovirus for potent knockdown of CGB
	adenovirus for overexpression of CGB
	stable overexpressing cell line services for CGB
	inducible overexpressing cell line services for CGB

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013 , 14 May 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CGB gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 106 solr: 1.4

Advanced Search

Export list of displayed genes

CGB Gene

chorionic gonadotropin, beta polypeptide

Aliases
for CGB gene

Summaries
for CGB gene

Genomic Views
for CGB gene

Proteins
for CGB gene

Protein Domains /
Families
for CGB gene

Function
for CGB gene

Pathways & Interactions
for CGB gene

Drugs & Compounds
for CGB gene

Transcripts
for CGB gene

Expression
for CGB gene

Orthologs
for CGB gene

Paralogs
for CGB gene

Genomic Variants
for CGB gene

Disorders / Diseases
for CGB gene

Publications
for CGB gene

External Searches for CGB gene

Genome Databases showing CGB gene

Other Databases showing CGB gene

Specialized Databases showing CGB gene

Intellectual Property
for CGB gene

Products
for CGB gene

View Random Gene

Abortion Tubal
Down Syndrome
Pregnancy loss
preterm delivery
Infertility
Serotonin syndrome
Pineal Tumors
PREGNANCY TUBAL RUPTURED
LUNG CARCINOMA
Pregnancy Tubal
Turners Syndrome
Breast Cancer
Hyperthyroidism
NSCLC
primary tumor
ADNEXAL MASS
Adenocarcinoma
Seminoma
Carcinoma Transitional Cell
Klinefelters Syndrome
Cancer
Hemolysis
Epidermoid Cyst
Miscarriage
Ovarian Cancer
RENAL DISEASE
Colorectal Cancer
Testicular Cancer
Cysts
Bladder Tumors
Hepatitis B
Anemia
prostate cancer
Tumors
Trisomy
Metastasis
Sarcoma
Preeclampsia
Abortion Threatened
progressive disease
Melanoma
Brain Tumors
BREAST CARCINOMA
bladder cancer
Hyperprolactinemia
Germinoma
Prolactinoma
Carcinoma
Tricuspid Regurgitation
Trophoblastic Tumor Placental Site
Acromegaly
Leukemia
PROSTATE CARCINOMA
Hemoperitoneum
Intrauterine death
Hydatidiform Mole
Osteosarcoma
High-Risk Pregnancy
congenital malformation
Neural Tube Defects
Carcinoma Renal Cell
Intrauterine Growth Retardation
Cancer Lung
Carcinoma Undifferentiated
Ascites
gestational trophoblastic disease
Adenoma
Bleeding
Cholangiocarcinoma
Teratoma
Carcinoma Squamous Cell
Trophoblastic disease
BLADDER CARCINOMA
Hematoma
Superior Vena Cava Syndrome
RUPTURED ECTOPIC PREGNANCY
Pregnancy Ectopic
Chromosomal Aberrations
Carcinoma Embryonal
Yolk Sac Tumor
Pregnancy Complications
Choriocarcinoma

Advanced Search

Export list of displayed genes

CGB Gene

chorionic gonadotropin, beta polypeptide

Aliasesfor CGB gene

Summariesfor CGB gene

Genomic Viewsfor CGB gene

Proteinsfor CGB gene

Protein Domains /Familiesfor CGB gene

Functionfor CGB gene

Pathways & Interactionsfor CGB gene

Drugs & Compoundsfor CGB gene

Transcriptsfor CGB gene

Expression for CGB gene

Orthologsfor CGB gene

Paralogsfor CGB gene

Genomic Variantsfor CGB gene

Disorders / Diseasesfor CGB gene

Publicationsfor CGB gene

External Searches for CGB gene

Genome Databases showing CGB gene

Other Databases showing CGB gene

Specialized Databases showing CGB gene

Intellectual Propertyfor CGB gene

Productsfor CGB gene

View Random Gene

Aliases
for CGB gene

Summaries
for CGB gene

Genomic Views
for CGB gene

Proteins
for CGB gene

Protein Domains /
Families
for CGB gene

Function
for CGB gene

Pathways & Interactions
for CGB gene

Drugs & Compounds
for CGB gene

Transcripts
for CGB gene

Expression
for CGB gene

Orthologs
for CGB gene

Paralogs
for CGB gene

Genomic Variants
for CGB gene

Disorders / Diseases
for CGB gene

Publications
for CGB gene

Intellectual Property
for CGB gene

Products
for CGB gene