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CGB Gene

protein-coding   GIFtS: 63
GCID: GC19M049526

Chorionic Gonadotropin, Beta Polypeptide

  See CGB-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Chorionic Gonadotropin, Beta Polypeptide1 2     CGB82
Chorionic Gonadotrophin Chain Beta2 3     Choriogonadotropin Subunit Beta2
CG-beta2 3     Chorionic Gonadotropin Beta 3 Subunit2
CGB32 3     Chorionic Gonadotropin Beta Chain2
CGB52     Chorionic Gonadotropin Beta Subunit2
CGB72     hCGB2

External Ids:    HGNC: 18861   Entrez Gene: 10822   Ensembl: ENSG000001048277   OMIM: 1188605   UniProtKB: P012333   

Export aliases for CGB gene to outside databases

Previous GC identifers: GC19M050184 GC19M049894 GC19M054202 GC19M054218 GC19M054222 GC19M054223 GC19M045902


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CGB Gene:
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic
gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta
subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and
stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta
subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and
contiguous with the luteinizing hormone beta subunit gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CGB Gene:
CGB (chorionic gonadotropin, beta polypeptide) is a protein-coding gene. Diseases associated with CGB include sarcomatoid renal cell carcinoma, and triploidy. GO annotations related to this gene include hormone activity. An important paralog of this gene is CGB7.

UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

Gene Wiki entry for CGB (Chorionic gonadotropin beta) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000019.9  NT_011109.17  NC_018930.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CGB gene promoter:
         AhR   NF-1   NF-1/L   Pax-5   POU3F1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCGB promoter sequence
   Search Chromatin IP Primers for CGB

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CGB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

CGB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CGB gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049526:  view genomic region     (about GC identifiers)

Start:
49,526,126 bp from pter      End:
49,527,593 bp from pter
Size:
1,468 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233 (See protein sequence)
Recommended Name: Choriogonadotropin subunit beta precursor  
Size: 165 amino acids; 17739 Da
Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to
thyrotropin, lutropin, follitropin and gonadotropin
Developmental stage: Made by the first trimester placenta
Sequence caution: Sequence=CAA25068.1; Type=Erroneous initiation; Sequence=CAA25069.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for CGB:
1HCN (3D)        1HRP (3D)        1QFW (3D)        1XUL (3D)    
Secondary accessions: A1A5E0 B9ZVP5 Q13991 Q14000 Q3KPI3 Q3SY41 Q8WTT5 Q8WXL1 Q8WXL2 Q8WXL3
Q8WXL4
Alternative splicing: 2 isoforms:  P01233-1   P01233-2   (Ref.2 (CAA25069) sequence is in conflict in positions: 7:G->R, 9:A->V, 12:D->G)

Explore the universe of human proteins at neXtProt for CGB: NX_P01233

Explore proteomics data for CGB at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn33, Asn50, Ser141, Ser147, Ser152, Ser158
  • Modification sites at PhosphoSitePlus

  • See CGB Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_000728.1  
    ENSEMBL proteins: 
     ENSP00000349954  
    Reactome Protein details: P01233

    CGB Human Recombinant Protein Products:

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    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for CGB (9 products) 

     
    antibodies-online peptides for CGB

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR018245 Gonadotropin_bsu_CS
     IPR001545 Gonadotropin_bsu
     IPR006208 Cys_knot

    Graphical View of Domain Structure for InterPro Entry P01233

    ProtoNet protein and cluster: P01233

    3 Blocks protein domains:
    IPB001545 Gonadotropin
    IPB002400 Growth factor cystine knot superfamily signature
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Similarity: Belongs to the glycoprotein hormones subunit beta family


    Find genes that share domains with CGB           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CGHB_HUMAN, P01233
    Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

         Genatlas biochemistry entry for CGB:
    chorionic gonadotropin,beta subunit,including in a cluster (made of 6 genes and like-sequences and LHB)

         Gene Ontology (GO): 1 molecular function term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity IEA--
         
    Find genes that share ontologies with CGB           About GenesLikeMe


    Animal Models:
       genOway: Develop your customized and physiologically relevant rodent model for CGB

    miRNA
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CGHB_HUMAN, P01233: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    cytosol3
    endoplasmic reticulum1
    nucleus1
    peroxisome1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    Find genes that share ontologies with CGB           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CGB About    
    See pathways by source

    SuperPathContained pathways About
    1Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Peptide hormone biosynthesis0.00
    Glycoprotein hormones0.00
    2Biosynthesis of the N-glycan precursor (dolichol lipid-linked oligosaccharide, LLO) and transfer to a nascent protein
    Metabolism of proteins0.30
    3Selected targets of Oct 3 4
    Selected targets of Oct 3 4


    Find genes that share SuperPaths with CGB           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways



    1 Reactome Pathway for CGB
        Glycoprotein hormones


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CGB
    Interactions:

        Search GeneGlobe Interaction Network for CGB

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for CGB (P012332, 3 ENSP000003499544) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CGAP012152, 3, ENSP000003585954MINT-24926 I2D: score=5 STRING: ENSP00000358595
    LHCGRP228883, ENSP000002949544I2D: score=1 STRING: ENSP00000294954
    FSHBP012253, ENSP000002541224I2D: score=1 STRING: ENSP00000254122
    CKBP122773I2D: score=1 
    EWSR1Q018443I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS7723844
    GO:0007165signal transduction TAS10468638
    GO:0007267cell-cell signaling TAS6194155
    GO:0007292female gamete generation TAS10468638
    GO:0016486peptide hormone processing TAS--

    Find genes that share ontologies with CGB           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CGB (CGHB)

    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Pharmaceutical: Available under the names Novarel (Ferring) and Profasi (Serono). Used as adjunctive therapy in
    the treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting
    from caloric restriction, that it causes a more attractive or 'normal' distribution of fat, or that it decreases
    the hunger and discomfort associated with calorie-restricted diets

    Selected Novoseek inferred chemical compound relationships for CGB gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methotrexate 62.6 13 1377160 (2), 11172133 (1), 16036203 (1), 16519378 (1) (see all 11)
    etoposide 52.9 2 12940324 (1), 18813353 (1)
    bleomycin 49.4 1 18813353 (1)
    ctp 48.7 5 20110752 (1), 16122898 (1), 17641000 (1), 9815634 (1) (see all 5)
    progesterone 45.2 43 1377160 (4), 7520212 (4), 19802539 (2), 15188764 (2) (see all 27)
    ifosfamide 41 1 12940324 (1)
    oestriol 36.9 2 7530437 (1), 9639764 (1)
    estradiol 36.5 16 9926805 (1), 7520962 (1), 1702401 (1), 10322841 (1) (see all 15)
    cisplatin 36.1 2 12940324 (1), 18813353 (1)
    mifepristone 35.1 1 15188764 (1)



    Find genes that share compounds with CGB           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CGB gene: 
    NM_000737.3  

    Unigene Cluster for CGB:

    Chorionic gonadotropin, beta polypeptide
    Hs.446683  [show with all ESTs]
    Unigene Representative Sequence: NM_000737
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000357383(uc002plv.2)
    miRNA
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    Additional mRNA sequence: 

    AK291552.1 BC022796.1 BC106059.1 J00117.1 K03181.1 

    3 DOTS entries:

    DT.119691  DT.100837633  DT.97797965 

    Selected AceView cDNA sequences (see all 247):

    BC006290 BC069367 NM_033043 BC051378 AA331012 NM_033378 AA330859 CA944648 
    T50278 BC069526 AI138197 BE732062 BX358522 N40038 BQ004068 BU752684 
    BX339535 BQ003996 BQ007392 CF527999 BG434117 AA330413 BU752736 CF527786 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CGB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCGCGTGC
    CGB Expression
    About this image


    CGB expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 3) fully expand
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Trophoblast Cells Trophoblast
             Trophoblast-like cells
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 2 entries
             Syncytiotrophoblast-like cells
             placenta   
     
     NULL (Uncategorized)
             Trophoblast-like cells
    CGB Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CGB Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.446683

    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Tissue specificity: Placenta

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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CGB gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    36(a)
    1 → many
    6(80158039-80158659)
    zebrafish
    (Danio rerio)
    Actinopterygii lhb6
    luteinizing hormone, beta polypeptide
    39(a)
    1 → many
    Zv9_scaffold3525(54871-57837) ENSDARG00000035709
            Species with no ortholog for CGB

    ENSEMBL Gene Tree for CGB (if available)
    TreeFam Gene Tree for CGB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CGB gene
    CGB51 2  CGB81 2  CGB72  TSHB2  FSHB2  CGB22  LHB2  CGB12  
    ENSG000002673352  
    7 SIMAP similar genes for CGB using alignment to 1 protein entry:     CGHB_HUMAN:
    CGB8    CGB1    CGB2    CGB7    LHB    FSHB
    TSHB

    Find genes that share paralogs with CGB           About GenesLikeMe



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CGB (see all 143)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs113335531,2
    C,F--49525637(+) GACAAT/-TTTTT 1 -- ds50012Minor allele frequency- -:0.50NA CSA 4
    rs1181578101,2
    F--49525656(+) TGAGAC/TGGACT 1 -- ds50011Minor allele frequency- T:0.03NA 120
    rs1863362091,2
    C--49525765(+) GAGTAC/GCTGGG 1 -- ds50010--------
    rs794170051,2
    C,F--49525809(+) TCTTTA/GTGTAA 1 -- ds50013Minor allele frequency- G:0.10WA CSA 122
    rs1904476751,2
    --49525827(+) AGAGAC/TGGGGT 1 -- ds50010--------
    rs1825257301,2
    --49525902(+) TCAAAC/GTGCTG 1 -- ds50010--------
    rs1866531161,2
    --49525993(+) GTTGCA/GATGTC 1 -- ds50010--------
    rs1432278191,2
    C--49526005(+) TCCCCC/TGACCC 1 -- ds50010--------
    rs1920708791,2
    --49526008(+) CCCGAC/GCCCAC 1 -- ds50010--------
    rs72561861,2
    C--49526014(+) CCCACA/CCTGTT 1 -- ds50011Minor allele frequency- C:0.00NA 2

    HapMap Linkage Disequilibrium report for CGB (49526126 - 49527593 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CGB:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv912251CNV Loss21882294
    nsv833857CNV Loss17160897
    dgv3970n71CNV Loss21882294
    nsv912252CNV Loss21882294
    nsv833859CNV Loss17160897
    nsv912248CNV Loss21882294
    esv22462CNV Gain19812545
    nsv9739CNV Gain+Loss18304495

    Human Gene Mutation Database (HGMD): CGB
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CGB
    DNA2.0 Custom Variant and Variant Library Synthesis for CGB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 118860    OMIM disorders: --

    Selected diseases for CGB (see all 38):    
    About MalaCards
    sarcomatoid renal cell carcinoma    triploidy    ectopic pregnancy    placental site trophoblastic tumor
    choriocarcinoma    central nervous system germinoma    germinoma    testicular leydig cell tumor
    lymphoepithelioma-like carcinoma    mature teratoma    nonseminomatous germ cell tumor    superior vena cava syndrome
    central nervous system germ cell tumor    seminoma    testicular microlithiasis    teratoma
    adrenal rest tumor    klinefelter's syndrome    pulmonary blastoma    hyperprolactinemia

    1 disease from the University of Copenhagen DISEASES database for CGB:
    Cryptococcosis

    Find genes that share disorders with CGB           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CGB gene (see all 82)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pregnancy ectopic 82.4 32 10577398 (2), 9166176 (2), 1534728 (1), 8745091 (1) (see all 29)
    down syndrome 82.1 76 8623793 (5), 9396880 (4), 7485343 (3), 14981387 (3) (see all 54)
    germinoma 80.3 9 16015498 (1), 16010454 (1), 17140187 (1), 17339149 (1) (see all 9)
    choriocarcinoma 79.6 6 9639324 (2), 1723674 (1), 7514765 (1), 14628141 (1) (see all 5)
    hydatidiform mole 79.2 8 19517692 (1), 15171312 (1), 9988795 (1), 19691261 (1) (see all 8)
    pregnancy tubal ruptured 73.6 1 7514547 (1)
    gestational trophoblastic disease 73.6 7 11759958 (2), 9988795 (1), 7518517 (1), 12876023 (1) (see all 6)
    pregnancy tubal 73.4 4 16097977 (2), 7514547 (1), 12386356 (1)
    seminoma 73 13 1372658 (3), 8394368 (2), 1711586 (1), 16033057 (1) (see all 8)
    yolk sac tumor 67.3 3 7514765 (1), 19075540 (1), 15247758 (1)

    Genetic Association Database (GAD): CGB
    Human Genome Epidemiology (HuGE) Navigator: CGB (3 documents)

    Export disorders for CGB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CGB gene, integrated from 10 sources (see all 598):
    (articles sorted by number of sources associating them with CGB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PubMed id 6194155)1, 2, 3 Policastro P....Boime I. (J. Biol. Chem. 1983)
    2. The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region. (PubMed id 6774259)1, 2, 3 Fiddes J.C. and Goodman H.M. (Nature 1980)
    3. Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form. (PubMed id 1688430)1, 2, 9 Saccuzo Beebe J.... Ruddon R.W. (J. Biol. Chem. 1990)
    4. No evidence of the human chorionic gonadotropin-beta gene 5 betaV79M polymorphism in Mexican women. (PubMed id 19002615)1, 4 Dominguez-Lopez P....Arechavaleta-Velasco F. (Endocrine 2008)
    5. Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection. (PubMed id 11861891)1, 2 Maston G.A. and Ruvolo M. (Mol. Biol. Evol. 2002)
    6. Crystal structure of human chorionic gonadotropin. (PubMed id 8202136)1, 2 Lapthorn A.J.... Isaacs N.W. (Nature 1994)
    7. Site-specific N-glycosylation of human chorionic gonadotrophin -- structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy. (PubMed id 1820200)1, 2 Weisshaar G.... Renwick A.G.C. (Glycobiology 1991)
    8. A map of the hCG beta-LH beta gene cluster. (PubMed id 2422163)1, 2 Policastro P.F.... Boime I. (J. Biol. Chem. 1986)
    9. Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. (PubMed id 6690982)1, 2 Talmadge K.... Fiddes J.C. (Nature 1984)
    10. Reduction of human chorionic gonadotropin beta subunit expression by modified U1 snRNA caused apoptosis in cervical cancer cells. (PubMed id 18339208)1, 9 Jankowska A....Warchol J.B. (Mol. Cancer 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1082 HGNC: 1886 AceView: CGB5andCGB2 Ensembl:ENSG00000104827 euGenes: HUgn1082
    ECgene: CGB H-InvDB: CGB

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CGB Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Human_chorionic_gonadotropin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CGB gene:
    Search GeneIP for patents involving CGB

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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