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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CGB Gene

protein-coding   GIFtS: 62
GCID: GC19M049526

Chorionic Gonadotropin, Beta Polypeptide

  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Chorionic Gonadotropin, Beta Polypeptide1 2     CGB82
Chorionic Gonadotrophin Chain Beta2 3     Choriogonadotropin Subunit Beta2
CG-beta2 3     Chorionic Gonadotropin Beta 3 Subunit2
CGB32 3     Chorionic Gonadotropin Beta Chain2
CGB52     Chorionic Gonadotropin Beta Subunit2
CGB72     hCGB2

External Ids:    HGNC: 18861   Entrez Gene: 10822   Ensembl: ENSG000001048277   OMIM: 1188605   UniProtKB: P012333   

Export aliases for CGB gene to outside databases

Previous GC identifers: GC19M050184 GC19M049894 GC19M054202 GC19M054218 GC19M054222 GC19M054223 GC19M045902


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CGB Gene:
This gene is a member of the glycoprotein hormone beta chain family and encodes the beta 3 subunit of chorionic
gonadotropin (CG). Glycoprotein hormones are heterodimers consisting of a common alpha subunit and an unique beta
subunit which confers biological specificity. CG is produced by the trophoblastic cells of the placenta and
stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy. The beta
subunit of CG is encoded by 6 genes which are arranged in tandem and inverted pairs on chromosome 19q13.3 and
contiguous with the luteinizing hormone beta subunit gene. (provided by RefSeq, Jul 2008)

GeneCards Summary for CGB Gene: 
CGB (chorionic gonadotropin, beta polypeptide) is a protein-coding gene. Diseases associated with CGB include ectopic pregnancy, and germinoma, and among its related super-pathways are Peptide hormone biosynthesis and Insulin Processing. GO annotations related to this gene include hormone activity. An important paralog of this gene is CGB7.

UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

Gene Wiki entry for CGB (Chorionic gonadotropin beta) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000019.9  NT_011109.16  NC_018930.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CGB gene promoter:
         AhR   NF-1   NF-1/L   Pax-5   POU3F1   GATA-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCGB promoter sequence
   Search SABiosciences Chromatin IP Primers for CGB

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CGB


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 19q13.32   Ensembl cytogenetic band:  19q13.33   HGNC cytogenetic band: 19q13.3

CGB Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CGB gene location

GeneLoc information about chromosome 19         GeneLoc Exon Structure

GeneLoc location for GC19M049526:  view genomic region     (about GC identifiers)

Start:
49,526,126 bp from pter      End:
49,527,593 bp from pter
Size:
1,468 bases      Orientation:
minus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233 (See protein sequence)
Recommended Name: Choriogonadotropin subunit beta precursor  
Size: 165 amino acids; 17739 Da
Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to
thyrotropin, lutropin, follitropin and gonadotropin
Subcellular location: Secreted
Developmental stage: Made by the first trimester placenta
Sequence caution: Sequence=CAA25068.1; Type=Erroneous initiation; Sequence=CAA25069.1; Type=Erroneous initiation;
4 PDB 3D structures from and Proteopedia for CGB:
1HCN (3D)        1HRP (3D)        1QFW (3D)        1XUL (3D)    
Secondary accessions: A1A5E0 B9ZVP5 Q13991 Q14000 Q3KPI3 Q3SY41 Q8WTT5 Q8WXL1 Q8WXL2 Q8WXL3
Q8WXL4
Alternative splicing: 2 isoforms:  P01233-1   P01233-2   (Ref.2 (CAA25069) sequence is in conflict in positions: 7:G->R, 9:A->V, 12:D->G)

Explore the universe of human proteins at neXtProt for CGB: NX_P01233

Explore proteomics data for CGB at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P01233

  • CGB Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CGB Protein Expression
    REFSEQ proteins: NP_000728.1  
    ENSEMBL proteins: 
     ENSP00000349954  
    Reactome Protein details: P01233
    Human Recombinant Protein Products for CGB: 
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    Novus Biologicals CGB Proteins
    Novus Biologicals CGB Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Browse Proteins at Cloud-Clone Corp. 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    CGB for ontologies           About GeneDecksing



    CGB Antibody Products: 
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    Browse CLIAs at Cloud-Clone Corp.


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    ENDOLIG: Endogenous ligands

    3 InterPro protein domains:
     IPR018245 Gonadotropin_bsu_CS
     IPR001545 Gonadotropin_bsu
     IPR006208 Cys_knot

    Graphical View of Domain Structure for InterPro Entry P01233

    ProtoNet protein and cluster: P01233

    3 Blocks protein domains:
    IPB001545 Gonadotropin
    IPB002400 Growth factor cystine knot superfamily signature
    IPB006208 Cystine knot domain


    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Similarity: Belongs to the glycoprotein hormones subunit beta family


    CGB for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CGHB_HUMAN, P01233
    Function: Stimulates the ovaries to synthesize the steroids that are essential for the maintenance of pregnancy

         Genatlas biochemistry entry for CGB:
    chorionic gonadotropin,beta subunit,including in a cluster (made of 6 genes and like-sequences and LHB)

         Gene Ontology (GO): 1 molecular function term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity IEA--
         
    CGB for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CGB 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CGB About                                                                                                See pathways by source

    SuperPathContained pathways About
    1Glycoprotein hormones
    Glycoprotein hormones0.71
    Peptide hormone biosynthesis0.71
    2Insulin Processing
    Peptide hormone metabolism0.39
    3Asparagine N-linked glycosylation
    Metabolism of proteins0.35
    4Selected targets of Oct-3/4
    Selected targets of Oct-3/4

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 EMD Millipore Pathway for CGB
        Selected targets of Oct-3/4



    4        Reactome Pathways for CGB
        Peptide hormone biosynthesis
    Metabolism of proteins
    Glycoprotein hormones
    Peptide hormone metabolism



    CGB for pathways           About GeneDecksing

    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CGB

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    5 Interacting proteins for CGB (P012332, 3 ENSP000003499544) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CGAP012152, 3, ENSP000003585954MINT-24926 I2D: score=5 STRING: ENSP00000358595
    LHCGRP228883, ENSP000002949544I2D: score=1 STRING: ENSP00000294954
    FSHBP012253, ENSP000002541224I2D: score=1 STRING: ENSP00000254122
    CKBP122773I2D: score=1 
    EWSR1Q018443I2D: score=1 
    About this table

    Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006915apoptotic process TAS7723844
    GO:0007165signal transduction TAS10468638
    GO:0007267cell-cell signaling TAS6194155
    GO:0007292female gamete generation TAS10468638
    GO:0016486peptide hormone processing TAS--

    CGB for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CGB for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CGB (CGHB)

    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Pharmaceutical: Available under the names Novarel (Ferring) and Profasi (Serono). Used as adjunctive therapy in
    the treatment of obesity. There is no substantial evidence that it increases weight loss beyond that resulting
    from caloric restriction, that it causes a more attractive or 'normal' distribution of fat, or that it decreases
    the hunger and discomfort associated with calorie-restricted diets

    10/28 Novoseek inferred chemical compound relationships for CGB gene (see all 28)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    methotrexate 62.6 13 1377160 (2), 11172133 (1), 16036203 (1), 16519378 (1) (see all 11)
    etoposide 52.9 2 12940324 (1), 18813353 (1)
    bleomycin 49.4 1 18813353 (1)
    ctp 48.7 5 20110752 (1), 16122898 (1), 17641000 (1), 9815634 (1) (see all 5)
    progesterone 45.2 43 1377160 (4), 7520212 (4), 19802539 (2), 15188764 (2) (see all 27)
    ifosfamide 41 1 12940324 (1)
    oestriol 36.9 2 7530437 (1), 9639764 (1)
    estradiol 36.5 16 9926805 (1), 7520962 (1), 1702401 (1), 10322841 (1) (see all 15)
    cisplatin 36.1 2 12940324 (1), 18813353 (1)
    mifepristone 35.1 1 15188764 (1)

    Search CenterWatch for drugs/clinical trials and news about CGB / CGHB

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CGB gene: 
    NM_000737.3  

    Unigene Clusters for CGB:

    Chorionic gonadotropin, beta polypeptide
    Hs.446683  [show with all ESTs], Hs.743279  [show with all ESTs]
    Unigene Representative Sequences: NM_000737, BC030994
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000357383(uc002plv.2)
    miRNA
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    Additional mRNA sequence: 

    BC030994.1 BC069526.1 BC103969.1 BC128603.1 

    4 DOTS entries:

    DT.119691  DT.100837633  DT.97797965  DT.121475036 

    24/247 AceView cDNA sequences (see all 247):

    T50278 NM_033378 BC069367 NM_033043 AA331012 BC006290 AA330859 BC051378 
    CA944648 BF589174 BX358708 AA330755 CF528653 AI417614 N32108 BU752684 
    CB998315 N29831 BX358522 BQ007392 BQ011244 BU752320 BX439414 BG434117 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CGB expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ACCCGCGTGC
    CGB Expression
    About this image


    See CGB Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CGB

    SOURCE GeneReport for Unigene clusters: Hs.446683 Hs.743279

    UniProtKB/Swiss-Prot: CGHB_HUMAN, P01233
    Tissue specificity: Placenta

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CGB gene from 3/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    37(a)
    1 → many
    6(80158039-80158659)
    zebrafish
    (Danio rerio)
    Actinopterygii lhb6
    luteinizing hormone, beta polypeptide
    39(a)
    1 → many
    Zv9_scaffold3525(54871-57837)
    fruit fly
    (Drosophila melanogaster)
    Insecta Gpb56
    Glycoprotein hormone beta 5
    13(a)
    1 → many
    2LHet(167215-167979)
            Species with no ortholog for CGB

    ENSEMBL Gene Tree for CGB (if available)
    TreeFam Gene Tree for CGB (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CGB gene
    CGB51 2  CGB81 2  CGB72  TSHB2  FSHB2  CGB22  LHB2  CGB12  
    ENSG000002673352  
    7 SIMAP similar genes for CGB using alignment to 1 protein entry:     CGHB_HUMAN:
    CGB8    CGB1    CGB2    CGB7    LHB    FSHB
    TSHB

    CGB for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/143 SNPs in CGB are shown (see all 143)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 19 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0152334
    ----see VAR_0152332 R W mis40--------
    VAR_0152324
    ----see VAR_0152322 P M mis40--------
    VAR_0145854
    ----see VAR_0145852 F L mis40--------
    VAR_0152354
    ----see VAR_0152352 S C mis40--------
    VAR_0145864
    ----see VAR_0145862 K R mis40--------
    VAR_0152344
    ----see VAR_0152342 R H mis40--------
    VAR_0145874
    ----see VAR_0145872 T I mis40--------
    VAR_0145884
    ----see VAR_0145882 N D mis40--------
    VAR_0031884
    ----see VAR_0031882 D A mis40--------
    VAR_0152314
    ----see VAR_0152312 T A mis40--------

    HapMap Linkage Disequilibrium report for CGB (49526126 - 49527593 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 8 variations for CGB:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv912251CNV Loss21882294
    nsv833857CNV Loss17160897
    dgv3970n71CNV Loss21882294
    nsv912252CNV Loss21882294
    nsv833859CNV Loss17160897
    nsv912248CNV Loss21882294
    esv22462CNV Gain19812545
    nsv9739CNV Gain+Loss18304495


    Human Gene Mutation Database (HGMD): CGB
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CGB
    DNA2.0 Custom Variant and Variant Library Synthesis for CGB

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 118860    OMIM disorders: --

    20/103 diseases for CGB (see all 103):    About MalaCards
    ectopic pregnancy    germinoma    choriocarcinoma    central nervous system germ cell tumor
    nonseminomatous germ cell tumor    placental site trophoblastic tumor    mature teratoma    triploidy
    superior vena cava syndrome    seminoma    extragonadal germ cell tumor    testicular leydig cell tumor
    central nervous system germinoma    lymphoepithelioma-like carcinoma    mixed ductal-endocrine carcinoma    germ cell tumors
    teratoma    klinefelter's syndrome    sarcomatoid renal cell carcinoma    adrenal rest tumor

    1 disease from the University of Copenhagen DISEASES database for CGB:
    Cryptococcosis

    CGB for disorders           About GeneDecksing

    10/82 Novoseek inferred disease relationships for CGB gene (see all 82)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    pregnancy ectopic 82.4 32 10577398 (2), 9166176 (2), 1534728 (1), 8745091 (1) (see all 29)
    down syndrome 82.1 76 8623793 (5), 9396880 (4), 7485343 (3), 14981387 (3) (see all 54)
    germinoma 80.3 9 16015498 (1), 16010454 (1), 17140187 (1), 17339149 (1) (see all 9)
    choriocarcinoma 79.6 6 9639324 (2), 1723674 (1), 7514765 (1), 14628141 (1) (see all 5)
    hydatidiform mole 79.2 8 19517692 (1), 15171312 (1), 9988795 (1), 19691261 (1) (see all 8)
    pregnancy tubal ruptured 73.6 1 7514547 (1)
    gestational trophoblastic disease 73.6 7 11759958 (2), 9988795 (1), 7518517 (1), 12876023 (1) (see all 6)
    pregnancy tubal 73.4 4 16097977 (2), 7514547 (1), 12386356 (1)
    seminoma 73 13 1372658 (3), 8394368 (2), 1711586 (1), 16033057 (1) (see all 8)
    yolk sac tumor 67.3 3 7514765 (1), 19075540 (1), 15247758 (1)

    Genetic Association Database (GAD): CGB
    Human Genome Epidemiology (HuGE) Navigator: CGB (3 documents)

    Export disorders for CGB gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CGB gene, integrated from 9 sources (see all 593):
    (articles sorted by number of sources associating them with CGB)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The beta subunit of human chorionic gonadotropin is encoded by multiple genes. (PubMed id 6194155)1, 2, 3 Policastro P....Boime I. (1983)
    2. The cDNA for the beta-subunit of human chorionic gonadotropin suggests evolution of a gene by readthrough into the 3'-untranslated region. (PubMed id 6774259)1, 2, 3 Fiddes J.C. and Goodman H.M. (1980)
    3. Role of disulfide bond formation in the folding of human chorionic gonadotropin beta subunit into an alpha beta dimer assembly-competent form. (PubMed id 1688430)1, 2, 9 Saccuzo Beebe J.... Ruddon R.W. (1990)
    4. No evidence of the human chorionic gonadotropin-beta gene 5 betaV79M polymorphism in Mexican women. (PubMed id 19002615)1, 4 Dominguez-Lopez P....Arechavaleta-Velasco F. (2008)
    5. Chorionic gonadotropin has a recent origin within primates and an evolutionary history of selection. (PubMed id 11861891)1, 2 Maston G.A. and Ruvolo M. (2002)
    6. Crystal structure of human chorionic gonadotropin. (PubMed id 8202136)1, 2 Lapthorn A.J.... Isaacs N.W. (1994)
    7. Site-specific N-glycosylation of human chorionic gonadotrophin -- structural analysis of glycopeptides by one- and two-dimensional 1H NMR spectroscopy. (PubMed id 1820200)1, 2 Weisshaar G.... Renwick A.G.C. (1991)
    8. A map of the hCG beta-LH beta gene cluster. (PubMed id 2422163)1, 2 Policastro P.F.... Boime I. (1986)
    9. Evolution of the genes for the beta subunits of human chorionic gonadotropin and luteinizing hormone. (PubMed id 6690982)1, 2 Talmadge K.... Fiddes J.C. (1984)
    10. Reduction of human chorionic gonadotropin beta subunit expression by modified U1 snRNA caused apoptosis in cervical cancer cells. (PubMed id 18339208)1, 9 Jankowska A....Warchol J.B. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1082 HGNC: 1886 AceView: CGB5andCGB2 Ensembl:ENSG00000104827 euGenes: HUgn1082
    ECgene: CGB H-InvDB: CGB

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CGB Pharmacogenomics, SNPs, Pathways
    Wikipedia http://en.wikipedia.org/wiki/Human_chorionic_gonadotropin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CGB gene:
    Search GeneIP for patents involving CGB

    GeneCards and IP:
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