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CGA Gene

protein-coding   GIFtS: 67
GCID: GC06M087795

Glycoprotein Hormones, Alpha Polypeptide

  See CGA-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Glycoprotein Hormones, Alpha Polypeptide1 2     LSH-alpha2 3
Luteinizing Hormone Alpha Chain1 2 3     TSH-alpha2 3
Lutropin Alpha Chain1 2 3     Alpha Polypeptide1
Thyroid-Stimulating Hormone Alpha Chain1 2 3     Chorionic Gonadotropin1
Follicle-Stimulating Hormone Alpha Subunit1 2     CG-ALPHA2
Glycoprotein Hormones Alpha Chain1 2     FSHA2
Anterior Pituitary Glycoprotein Hormones Common Subunit Alpha2 3     GPHA12
Choriogonadotropin Alpha Chain2 3     GPHa2
Chorionic Gonadotrophin Subunit Alpha2 3     HCG2
Follicle-Stimulating Hormone Alpha Chain2 3     LHA2
Follitropin Alpha Chain2 3     TSHA2
Thyrotropin Alpha Chain2 3     Chorionic Gonadotropin, Alpha Polypeptide2
FSH-alpha2 3     CG-alpha3

External Ids:    HGNC: 18851   Entrez Gene: 10812   Ensembl: ENSG000001353467   OMIM: 1188505   UniProtKB: P012153   

Export aliases for CGA gene to outside databases

Previous GC identifers: GC06M087741 GC06M087790 GC06M087851 GC06M085012


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CGA Gene:
The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating
hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are
associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are
unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to
the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found
for this gene. (provided by RefSeq, Nov 2011)

GeneCards Summary for CGA Gene:
CGA (glycoprotein hormones, alpha polypeptide) is a protein-coding gene. Diseases associated with CGA include anovulation, and ovarian remnant syndrome. GO annotations related to this gene include hormone activity.

Gene Wiki entry for CGA (Chorionic gonadotropin alpha) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000006.11  NC_018917.2  NT_025741.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CGA gene promoter:
         CREB   AML1a   deltaCREB   En-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCGA promoter sequence
   Search Chromatin IP Primers for CGA

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CGA


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q12-q21   Ensembl cytogenetic band:  6q14.3   HGNC cytogenetic band: 6q14-q21

CGA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CGA gene location

GeneLoc information about chromosome 6         GeneLoc Exon Structure

GeneLoc location for GC06M087795:  view genomic region     (about GC identifiers)

Start:
87,795,216 bp from pter      End:
87,804,824 bp from pter
Size:
9,609 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: GLHA_HUMAN, P01215 (See protein sequence)
Recommended Name: Glycoprotein hormones alpha chain precursor  
Size: 116 amino acids; 13075 Da
Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to
thyrotropin, lutropin, follitropin and gonadotropin
Selected PDB 3D structures from and Proteopedia for CGA (see all 10):
1DZ7 (3D)        1E9J (3D)        1FL7 (3D)        1HCN (3D)        1HD4 (3D)        1HRP (3D)    

Explore the universe of human proteins at neXtProt for CGA: NX_P01215

Explore proteomics data for CGA at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn76, Asn102
  • Modification sites at PhosphoSitePlus

  • See CGA Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000726.1  NP_001239312.1  

    ENSEMBL proteins: 
     ENSP00000358595  
    Reactome Protein details: P01215

    CGA Human Recombinant Protein Products:

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    Browse Sino Biological Recombinant Proteins
    Sino Biological Cell Lysate for CGA
    ProSpec Recombinant Protein for CGA
    Browse Proteins at Cloud-Clone Corp.

     
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    antibodies-online proteins for CGA (35 products) 

     
    antibodies-online peptides for CGA

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    antibodies-online antibodies for CGA (176 products) 

    CGA Assay Products:

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    Browse ELISAs at Cloud-Clone Corp.
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    Search eBioscience for ELISAs for CGA 
    antibodies-online kits for CGA (23 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    1 InterPro protein domain:
     IPR000476 Glyco_hormone

    Graphical View of Domain Structure for InterPro Entry P01215

    ProtoNet protein and cluster: P01215

    2 Blocks protein domains:
    IPB000476 Glycoprotein hormones alpha chain
    IPB002400 Growth factor cystine knot superfamily signature


    UniProtKB/Swiss-Prot: GLHA_HUMAN, P01215
    Similarity: Belongs to the glycoprotein hormones subunit alpha family


    Find genes that share domains with CGA           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:
         Genatlas biochemistry entry for CGA:
    glycoprotein hormones,alpha polypeptide,common to chorionic gonadotropin,FSH,LH,TSH

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005179hormone activity IEA--
    GO:0005515protein binding IPI11222739
         
    Find genes that share ontologies with CGA           About GenesLikeMe


    Phenotypes:
         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Cga):
     endocrine/exocrine gland  growth/size/body  homeostasis/metabolism  nervous system  reproductive system 

    Find genes that share phenotypes with CGA           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cgatm1Sac for CGA

       genOway: Develop your customized and physiologically relevant rodent model for CGA

    miRNA
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    miRTarBase miRNAs that target CGA:
    hsa-mir-335-5p (MIRT018742)

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    SwitchGear 3'UTR luciferase reporter plasmidCGA 3' UTR sequence
    Inhib. RNA
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    Gene Editing
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    eBioscience FlowRNA Probe Sets ( VA6-12883) for CGA 


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    GLHA_HUMAN, P01215: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    nucleus2
    chloroplast1
    plasma membrane1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--

    Find genes that share ontologies with CGA           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CGA About   (see all 22)  
    See pathways by source

    SuperPathContained pathways About
    1Peptide ligand-binding receptors
    Class A/1 (Rhodopsin-like receptors)0.71
    Neuroactive ligand-receptor interaction0.36
    GPCR ligand binding0.71
    2Signaling by GPCR
    Signaling by GPCR0.90
    Signal Transduction0.58
    GPCR downstream signaling0.90
    3Peptide hormone metabolism
    Peptide hormone metabolism0.30
    Peptide hormone biosynthesis0.00
    Glycoprotein hormones0.00
    4Metabolism of steroid hormones and vitamin D
    Mineralocorticoid biosynthesis0.00
    Androgen biosynthesis0.00
    Metabolism of steroid hormones and vitamin D
    5Metabolism of amino acids and derivatives
    Metabolism of amino acids and derivatives
    Thyroxine biosynthesis0.00
    Amine-derived hormones0.00


    Find genes that share SuperPaths with CGA           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    1 Downloadable PowerPoint Slide of GeneGlobe Pathway Central Maps for CGA
        GnRH Signaling

    2 GeneGo (Thomson Reuters) Pathways for CGA
        Transcription Role of VDR in regulation of genes involved in osteoporosis
    Development Role of Activin A in cell differentiation and proliferation

    4 BioSystems Pathways for CGA
        Thyroxine (Thyroid Hormone) Production
    FSH signaling pathway
    TSH signaling pathway
    Glucocorticoid receptor regulatory network


    Selected Reactome Pathways for CGA (see all 6)
        Thyroxine biosynthesis
    Mineralocorticoid biosynthesis
    Hormone ligand-binding receptors
    Androgen biosynthesis
    Glycoprotein hormones


    Selected Kegg Pathways  (Kegg details for CGA) (see all 6):
        Neuroactive ligand-receptor interaction
    GnRH signaling pathway
    Ovarian steroidogenesis
    Prolactin signaling pathway
    Thyroid hormone synthesis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CGA: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Angiogenic Growth Factors in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CGA

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    Selected Interacting proteins for CGA (P012151, 2, 3 ENSP000003585954) via UniProtKB, MINT, STRING, and/or I2D (see all 27)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CGBP012332, 3, ENSP000003499544MINT-24926 I2D: score=5 STRING: ENSP00000349954
    CGB5P012332, 3, ENSP000003014084MINT-24926 I2D: score=5 STRING: ENSP00000301408
    CGB8P012332, 3, ENSP000003475824MINT-24926 I2D: score=5 STRING: ENSP00000347582
    CGB7P012332, 3MINT-24926 I2D: score=5 
    PTPN12Q052092, 3MINT-61770 I2D: score=3 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 15):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006590thyroid hormone generation IEA--
    GO:0007165signal transduction TAS481597
    GO:0007267cell-cell signaling TAS481597
    GO:0008284positive regulation of cell proliferation NAS--
    GO:0008406gonad development IEA--

    Find genes that share ontologies with CGA           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CGA (GLHA)

    1 DrugBank Compound for CGA    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Alpha-D-Mannose-- 3458-28-4target----

    Selected Novoseek inferred chemical compound relationships for CGA gene (see all 138)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    oestriol 86.8 86 9512261 (3), 1494541 (2), 8624312 (2), 1836960 (2) (see all 69)
    progesterone 86.7 944 1761656 (6), 10997481 (6), 1379268 (6), 18492365 (6) (see all 99)
    gnrh 86.1 417 8603601 (8), 17183101 (8), 17174489 (6), 7997235 (6) (see all 99)
    clomiphene citrate 84.2 112 17070196 (4), 8567766 (3), 11775896 (3), 11595893 (3) (see all 52)
    cetrorelix 80.8 25 15284212 (2), 10686191 (2), 15665010 (1), 11679500 (1) (see all 18)
    estradiol 80.5 278 11497290 (6), 7951553 (4), 17031874 (4), 7819706 (3) (see all 99)
    buserelin 79.1 45 16751622 (3), 7769051 (2), 8612858 (2), 18577353 (2) (see all 29)
    testosterone 78.7 556 16751622 (7), 8075787 (6), 15562375 (6), 1601748 (6) (see all 99)
    ganirelix 76.5 12 15916659 (1), 16037104 (1), 9572414 (1), 20101851 (1) (see all 10)
    metrodin 72 7 8006130 (2), 7660716 (1), 10920087 (1), 2108196 (1) (see all 5)



    Find genes that share compounds with CGA           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CGA gene (2 alternative transcripts): 
    NM_000735.3  NM_001252383.1  

    Unigene Cluster for CGA:

    Glycoprotein hormones, alpha polypeptide
    Hs.119689  [show with all ESTs]
    Unigene Representative Sequence: AK023644
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000369582(uc021zci.1 uc003plj.2)
    miRNA
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    Additional mRNA sequence: 

    AB019569.1 AK023644.1 AK311972.1 BC010957.1 BC020782.1 BC055080.1 CR457427.1 FJ624078.1 
    FJ624079.1 V00518.1 

    18 DOTS entries:

    DT.91781433  DT.95152109  DT.100800521  DT.100855932  DT.95152115  DT.121386018  DT.91748275  DT.97772825 
    DT.100703812  DT.101985644  DT.121385758  DT.95152122  DT.100703816  DT.100703822  DT.121385745  DT.121385989 
    DT.91781405  DT.95152112 

    Selected AceView cDNA sequences (see all 891):

    CD107103 CR602651 CD239122 CD251030 BG623952 CD238209 CD238265 CR596397 
    CR611908 CD242512 BG572343 BG619066 AI692345 BX366877 BG623146 CD239716 
    W86567 CR622170 BG621386 CR595519 AL550786 BG619829 CD239717 BX355707 

    GeneLoc Exon Structure

    5 Alternative Splicing Database (ASD) splice patterns (SP) for CGA    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
    SP1:                    -                                   -                     
    SP2:                    -                 -                 -                     
    SP3:                    -           -     -                 -                     
    SP4:                    -                 -                                       
    SP5:                                      -                                       


    ECgene alternative splicing isoforms for CGA

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CGA expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGCTGCTGCT
    CGA Expression
    About this image


    CGA expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 5) fully expand
     
     Placenta (Extraembryonic Tissues)    fully expand to see all 3 entries
             Syncytiotrophoblast Multinuclear Cells Chorionic Villus
             Syncytiotrophoblast-like cells
     
     Trophoblast (Extraembryonic Tissues)    fully expand to see all 2 entries
             Trophoblast Cells Trophoblast
             Trophoblast-like cells
     
     NULL (Uncategorized)    fully expand to see all 2 entries
             Trophoblast-like cells
     
     Endocrine System (Endocrine System)    fully expand to see all 2 entries
             pituitary   
     
     Liver (Hepatobiliary System)
             Hepatocyte-like cells
    CGA Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CGA Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.119689
        Pathway & Disease-focused RT2 Profiler PCR Arrays including CGA: 
              cAMP / Ca2+ Signaling PathwayFinder in human mouse rat
              Angiogenic Growth Factors in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGA

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CGA gene from Selected species (see all 13)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cga1 , 5 glycoprotein hormones, alpha subunit1, 5 76.39(n)1
    73.33(a)1
      4 (16.86 cM)5
    126401  NM_009889.21  NP_034019.11 
     348937795 
    chicken
    (Gallus gallus)
    Aves CGA1 glycoprotein hormones, alpha polypeptide 69.17(n)
    69.17(a)
      421829  NM_001278021.1  NP_001264950.1 
    lizard
    (Anolis carolinensis)
    Reptilia CGA6
    glycoprotein hormones, alpha polypeptide
    72(a)
    1 ↔ 1
    1(176496928-176497068)
    African clawed frog
    (Xenopus laevis)
    Amphibia tsha-A2 thyroid stimulating hormone alpha (TSH-alpha) 77.75(n)    L07619.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.138962 Danio rerio gonadotropin alpha subunit mRNA, complete more 81.49(n)    AY424306.1 


    ENSEMBL Gene Tree for CGA (if available)
    TreeFam Gene Tree for CGA (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CGA (see all 259)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 6 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1149485011,2
    F--87773676(+) ATGTTC/TCCAAT 1 -- ds50011Minor allele frequency- T:0.03WA 118
    rs49868691,2
    C,F,H--87773983(-) AAGCCA/GGTTGC 1 -- ds500129Minor allele frequency- G:0.32MN NS EA NA WA CSA 2755
    rs1389537981,2
    C--87773984(+) CAACTA/GGCTTT 1 -- ds50010--------
    rs66311,2
    C,F,A,H--87774061(-) GCATTT/AAGCTT 1 -- ut3125Minor allele frequency- A:0.41MN NA NS EA WA CSA 1695
    rs77409511,2
    C--87774068(+) ATGCTA/GTATTC 1 -- ut31 ese30--------
    rs1917753311,2
    --87774090(+) AAAGAA/GCTAGA 1 -- ut310--------
    rs49868701,2
    F--87774105(-) CAGTAC/TAATCA 1 -- ut315Minor allele frequency- T:0.01MN 400
    rs1836383961,2
    --87774109(+) TGTACC/TGTAGG 1 -- ut310--------
    rs10554091,2
    C,F,O,A,H--87774112(-) TATCCT/CACAGT 1 -- ut31 ese334Minor allele frequency- C:0.22MN NA EA NS WA CSA 3431
    rs1398103781,2
    C,F--87774348(+) ATTACT/CGTGAC 2 /T syn12Minor allele frequency- C:0.00NA EU 5845

    HapMap Linkage Disequilibrium report for CGA (87795216 - 87804824 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CGA:    About this table    
    Variant IDTypeSubtypePubMed ID
    esv1002835CNV Deletion20482838
    nsv5385CNV Loss18451855

    Human Gene Mutation Database (HGMD): CGA
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CGA
    DNA2.0 Custom Variant and Variant Library Synthesis for CGA

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 118850    OMIM disorders: --

    Selected diseases for CGA (see all 47):    
    About MalaCards
    anovulation    ovarian remnant syndrome    scalp dermatosis    pineal region germinoma
    teratoma    ovarian hyperstimulation syndrome    placental site trophoblastic tumor    epispadias
    ectopic pregnancy    germ cell cancer    luteoma    germinoma
    intermittent explosive disorder    triploidy    mixed germ cell tumor    testicular cancer
    polyembryoma    cutis marmorata telangiectatica congenita    edwards syndrome    robinow syndrome

    4 diseases from the University of Copenhagen DISEASES database for CGA:
    Intermittent explosive disorder     Scalp dermatosis     Conduct disorder     Borderline personality disorder

    Find genes that share disorders with CGA           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CGA gene (see all 93)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    ovarian hyperstimulation syndrome 90.6 48 18238999 (2), 10221701 (1), 10966979 (1), 15807221 (1) (see all 40)
    pregnancy tubal 83.7 48 2406662 (4), 9348261 (3), 7926077 (2), 9070731 (2) (see all 31)
    down syndrome 80.7 241 10585342 (7), 17962101 (5), 19777489 (5), 7497141 (5) (see all 99)
    pregnancy ectopic 80.2 103 7682316 (4), 1379268 (3), 10834324 (3), 1386659 (3) (see all 62)
    infertility 79.2 70 10831544 (3), 12960071 (2), 18681993 (2), 11726579 (2) (see all 50)
    trophoblastic disease 72.8 32 11263936 (3), 8563483 (2), 16189178 (2), 7510202 (2) (see all 17)
    polycystic ovary syndrome 70.4 15 15734758 (2), 8476833 (1), 19146766 (1), 1901089 (1) (see all 14)
    miscarriage 70 70 20464754 (6), 16225575 (5), 7947503 (4), 10834324 (4) (see all 35)
    choriocarcinoma 69.7 52 1397383 (5), 17563738 (2), 10632747 (2), 2289629 (2) (see all 30)
    hydatidiform mole 67.4 39 8157712 (4), 16638033 (3), 16189178 (3), 8906012 (3) (see all 18)

    Genetic Association Database (GAD): CGA
    Human Genome Epidemiology (HuGE) Navigator: CGA (45 documents)

    Export disorders for CGA gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CGA gene, integrated from 10 sources (see all 1849):
    (articles sorted by number of sources associating them with CGA)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. The gene encoding the common alpha subunit of the four human glycoprotein hormones. (PubMed id 6286817)1, 2, 3 Fiddes J.C. and Goodman H.M. (J. Mol. Appl. Genet. 1981)
    2. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    3. Genetic susceptibility to distinct bladder cancer subphenotypes. (PubMed id 19692168)1, 4 Guey L.T....Malats N. (Eur. Urol. 2010)
    4. A large-scale candidate gene association study of age at menarche and age at natural menopause. (PubMed id 20734064)1, 4 He C....Hunter D.J. (Hum. Genet. 2010)
    5. Comprehensive analysis of common genetic variation in 61 genes related to steroid hormone and insulin-like growth factor-I metabolism and breast cancer risk in the NCI breast and prostate cancer cohort consortium. (PubMed id 20634197)1, 4 Canzian F....Feigelson H.S. (Hum. Mol. Genet. 2010)
    6. Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China. (PubMed id 19170196)1, 4 Shen M....Lan Q. (Environ. Mol. Mutagen. 2009)
    7. PTEN identified as important risk factor of chronic obstructive pulmonary disease. (PubMed id 19625176)1, 4 Hosgood H.D....Lan Q. (Respir Med 2009)
    8. The variant rs1867277 in FOXE1 gene confers thyroid cancer susceptibility through the recruitment of USF1/USF2 transcription factors. (PubMed id 19730683)1, 4 Landa I....Robledo M. (PLoS Genet. 2009)
    9. Quantitative trait loci predicting circulating sex steroid hormones in men from the NCI-Breast and Prostate Cancer Cohort Consortium (BPC3). (PubMed id 19574343)1, 4 Ahn J....Hayes R.B. (Hum. Mol. Genet. 2009)
    10. Genes related to sex steroids, neural growth, and social-emotional behavior are associated with autistic traits, empathy, and Asperger syndrome. (PubMed id 19598235)1, 4 Chakrabarti B....Baron-Cohen S. (Autism Res 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 1081 HGNC: 1885 AceView: CGA Ensembl:ENSG00000135346 euGenes: HUgn1081
    ECgene: CGA Kegg: 1081 H-InvDB: CGA

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CGA Pharmacogenomics, SNPs, Pathways
    Protein Spotlighthttp://web.expasy.org/spotlight/back_issues/077

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CGA gene:
    Search GeneIP for patents involving CGA

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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