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Aliases for CGA Gene

Aliases for CGA Gene

  • Glycoprotein Hormones, Alpha Polypeptide 2 3 5
  • Thyroid-Stimulating Hormone Alpha Chain 2 3 4
  • Luteinizing Hormone Alpha Chain 2 3 4
  • Lutropin Alpha Chain 2 3 4
  • Anterior Pituitary Glycoprotein Hormones Common Subunit Alpha 3 4
  • Follicle-Stimulating Hormone Alpha Subunit 2 3
  • Follicle-Stimulating Hormone Alpha Chain 3 4
  • Chorionic Gonadotrophin Subunit Alpha 3 4
  • Choriogonadotropin Alpha Chain 3 4
  • Follitropin Alpha Chain 3 4
  • Thyrotropin Alpha Chain 3 4
  • FSH-Alpha 3 4
  • LSH-Alpha 3 4
  • TSH-Alpha 3 4
  • CG-ALPHA 3 4
  • Chorionic Gonadotropin, Alpha Polypeptide 3
  • Glycoprotein Hormones Alpha Chain 2
  • Chorionic Gonadotropin 2
  • Alpha Polypeptide 2
  • GPHA1 3
  • FSHA 3
  • GPHa 3
  • TSHA 3
  • HCG 3
  • LHA 3

External Ids for CGA Gene

Previous GeneCards Identifiers for CGA Gene

  • GC06M087741
  • GC06M087790
  • GC06M087851
  • GC06M087795
  • GC06M085012

Summaries for CGA Gene

Entrez Gene Summary for CGA Gene

  • The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for CGA Gene

CGA (Glycoprotein Hormones, Alpha Polypeptide) is a Protein Coding gene. Diseases associated with CGA include ovarian remnant syndrome and scalp dermatosis. Among its related pathways are Signaling by GPCR and Metabolism. GO annotations related to this gene include hormone activity.

Gene Wiki entry for CGA Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGA Gene

Genomics for CGA Gene

Regulatory Elements for CGA Gene

Genomic Location for CGA Gene

Chromosome:
6
Start:
87,085,498 bp from pter
End:
87,095,406 bp from pter
Size:
9,909 bases
Orientation:
Minus strand

Genomic View for CGA Gene

Genes around CGA on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CGA Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CGA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGA Gene

Proteins for CGA Gene

  • Protein details for CGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01215-GLHA_HUMAN
    Recommended name:
    Glycoprotein hormones alpha chain
    Protein Accession:
    P01215

    Protein attributes for CGA Gene

    Size:
    116 amino acids
    Molecular mass:
    13075 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

    Three dimensional structures from OCA and Proteopedia for CGA Gene

neXtProt entry for CGA Gene

Proteomics data for CGA Gene at MOPED

Post-translational modifications for CGA Gene

  • Glycosylation at Asn 76 and Asn 102
  • Modification sites at PhosphoSitePlus

Other Protein References for CGA Gene

Antibody Products

  • R&D Systems Antibodies for CGA (Chorionic Gonadotropin alpha Chain (HCG alpha))

No data available for DME Specific Peptides for CGA Gene

Domains & Families for CGA Gene

Gene Families for CGA Gene

Graphical View of Domain Structure for InterPro Entry

P01215

UniProtKB/Swiss-Prot:

GLHA_HUMAN :
  • Belongs to the glycoprotein hormones subunit alpha family.
Family:
  • Belongs to the glycoprotein hormones subunit alpha family.
genes like me logo Genes that share domains with CGA: view

Function for CGA Gene

Molecular function for CGA Gene

GENATLAS Biochemistry:
glycoprotein hormones,alpha polypeptide,common to chorionic gonadotropin,FSH,LH,TSH
genes like me logo Genes that share phenotypes with CGA: view

Animal Models for CGA Gene

MGI Knock Outs for CGA:

Animal Model Products

miRNA for CGA Gene

miRTarBase miRNAs that target CGA

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CGA Gene

Localization for CGA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CGA Gene COMPARTMENTS Subcellular localization image for CGA gene
Compartment Confidence
extracellular 5
golgi apparatus 4
nucleus 2
plasma membrane 1

No data available for Gene Ontology (GO) - Cellular Components for CGA Gene

Pathways & Interactions for CGA Gene

genes like me logo Genes that share pathways with CGA: view

SIGNOR curated interactions for CGA Gene

Activates:

Gene Ontology (GO) - Biological Process for CGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006590 thyroid hormone generation IEA --
GO:0007165 signal transduction TAS 481597
GO:0007267 cell-cell signaling TAS 481597
GO:0016486 peptide hormone processing TAS --
GO:0030878 thyroid gland development IEA --
genes like me logo Genes that share ontologies with CGA: view

Drugs & Compounds for CGA Gene

(95) Drugs for CGA Gene - From: Novoseek, ClinicalTrials, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cetuximab Approved Pharma EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 713
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1684
leucovorin Approved Pharma 952
Folic Acid Approved Nutra 2924
Folate Nutra 2924

(56) Additional Compounds for CGA Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CGA: view

Transcripts for CGA Gene

Unigene Clusters for CGA Gene

Glycoprotein hormones, alpha polypeptide:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CGA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: -

Relevant External Links for CGA Gene

GeneLoc Exon Structure for
CGA
ECgene alternative splicing isoforms for
CGA

Expression for CGA Gene

mRNA expression in normal human tissues for CGA Gene

mRNA differential expression in normal tissues according to GTEx for CGA Gene

This gene is overexpressed in Pituitary (x52.6).

Protein differential expression in normal tissues from HIPED for CGA Gene

This gene is overexpressed in Placenta (65.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CGA Gene



SOURCE GeneReport for Unigene cluster for CGA Gene Hs.119689

genes like me logo Genes that share expression patterns with CGA: view

Protein tissue co-expression partners for CGA Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CGA Gene

Orthologs for CGA Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CGA 35
  • 98.64 (n)
  • 97.28 (a)
CGA 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CGA 36
  • 72 (a)
OneToOne
CGA 35
  • 80 (n)
  • 71.67 (a)
dog
(Canis familiaris)
Mammalia CGA 35
  • 83.89 (n)
  • 73.33 (a)
CGA 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cga 16
Cga 36
  • 73 (a)
OneToOne
Cga 35
  • 76.39 (n)
  • 73.33 (a)
oppossum
(Monodelphis domestica)
Mammalia CGA 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CGA 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cga 35
  • 76.11 (n)
  • 70.83 (a)
chicken
(Gallus gallus)
Aves CGA 36
  • 70 (a)
OneToOne
CGA 35
  • 69.17 (n)
  • 69.17 (a)
lizard
(Anolis carolinensis)
Reptilia CGA 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia tsha-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cga 35
  • 66.67 (n)
  • 65.83 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11927 35
zebrafish
(Danio rerio)
Actinopterygii cga 36
  • 56 (a)
OneToOne
cga 35
  • 65.2 (n)
  • 61.4 (a)
Dr.13896 35
Species with no ortholog for CGA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGA Gene

ENSEMBL:
Gene Tree for CGA (if available)
TreeFam:
Gene Tree for CGA (if available)

Paralogs for CGA Gene

No data available for Paralogs for CGA Gene

Variants for CGA Gene

Sequence variations from dbSNP and Humsavar for CGA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type
rs2011192 -- 87,086,515(-) acagg(C/T)gtgag intron-variant, splice-donor-variant
rs2274137 -- 87,087,936(+) TGCAC(A/C)TTTTC intron-variant
rs2274138 -- 87,088,238(+) AAAAA(A/C)AAAAA intron-variant
rs2031366 -- 87,096,172(+) ctgtc(G/T)cccaa upstream-variant-2KB
rs2242602 -- 87,095,492(-) GGAAA(A/T)GCTCT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CGA Gene

Variant ID Type Subtype PubMed ID
nsv5385 CNV Loss 18451855
esv1002835 CNV Deletion 20482838

Variation tolerance for CGA Gene

Residual Variation Intolerance Score: 43.1% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CGA Gene

HapMap Linkage Disequilibrium report
CGA
Human Gene Mutation Database (HGMD)
CGA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGA Gene

Disorders for CGA Gene

MalaCards: The human disease database

(22) MalaCards diseases for CGA Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
ovarian remnant syndrome
  • residual ovary syndrome
scalp dermatosis
  • dermatosis of scalp
triploidy
  • chromosome triploidy syndrome
ovarian hyperstimulation syndrome
  • secondary meig's syndrome
hydatidiform mole, recurrent, 1
  • hydatidiform mole, recurrent, 2
- elite association - COSMIC cancer census association via MalaCards
Search CGA in MalaCards View complete list of genes associated with diseases

Relevant External Links for CGA

Genetic Association Database (GAD)
CGA
Human Genome Epidemiology (HuGE) Navigator
CGA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CGA
genes like me logo Genes that share disorders with CGA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CGA Gene

Publications for CGA Gene

  1. The gene encoding the common alpha subunit of the four human glycoprotein hormones. (PMID: 6286817) Fiddes J.C. … Goodman H.M. (J. Mol. Appl. Genet. 1981) 2 3 4 67
  2. TSH elevations as the first laboratory evidence for pseudohypoparathyroidism type Ib (PHP-Ib). (PMID: 25403028) Molinaro A. … JA1ppner H. (J. Bone Miner. Res. 2014) 3
  3. Association between altered placental human chorionic gonadotrophin (hCG) production and the occurrence of cryptorchidism: a retrospective study. (PMID: 25064170) Chedane C. … Coutant R. (BMC Pediatr 2014) 3
  4. Human chorionic gonadotropin decreases human breast cancer cell proliferation and promotes differentiation. (PMID: 24753159) Liao X.H. … Zhang T.C. (IUBMB Life 2014) 3
  5. Low serum thyrotropin level and duration of suppression as a predictor of major osteoporotic fractures-the OPENTHYRO register cohort. (PMID: 24723381) Abrahamsen B. … HegedA1s L. (J. Bone Miner. Res. 2014) 3

Products for CGA Gene

Sources for CGA Gene

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