Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CGA Gene

Aliases for CGA Gene

  • Glycoprotein Hormones, Alpha Polypeptide 2 3
  • Thyroid-Stimulating Hormone Alpha Chain 2 3 4
  • Luteinizing Hormone Alpha Chain 2 3 4
  • Lutropin Alpha Chain 2 3 4
  • Anterior Pituitary Glycoprotein Hormones Common Subunit Alpha 3 4
  • Follicle-Stimulating Hormone Alpha Subunit 2 3
  • Follicle-Stimulating Hormone Alpha Chain 3 4
  • Chorionic Gonadotrophin Subunit Alpha 3 4
  • Choriogonadotropin Alpha Chain 3 4
  • Follitropin Alpha Chain 3 4
  • Thyrotropin Alpha Chain 3 4
  • FSH-Alpha 3 4
  • LSH-Alpha 3 4
  • TSH-Alpha 3 4
  • CG-ALPHA 3 4
  • Chorionic Gonadotropin, Alpha Polypeptide 3
  • Glycoprotein Hormones Alpha Chain 2
  • Chorionic Gonadotropin 2
  • Alpha Polypeptide 2
  • GPHA1 3
  • FSHA 3
  • GPHa 3
  • TSHA 3
  • HCG 3
  • LHA 3

External Ids for CGA Gene

Previous GeneCards Identifiers for CGA Gene

  • GC06M087741
  • GC06M087790
  • GC06M087851
  • GC06M087795
  • GC06M085012

Summaries for CGA Gene

Entrez Gene Summary for CGA Gene

  • The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for CGA Gene

CGA (Glycoprotein Hormones, Alpha Polypeptide) is a Protein Coding gene. Diseases associated with CGA include ectopic pregnancy and ovarian remnant syndrome. Among its related pathways are Signaling by GPCR and Transport to the Golgi and subsequent modification. GO annotations related to this gene include hormone activity.

Gene Wiki entry for CGA Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGA Gene

Genomics for CGA Gene

Regulatory Elements for CGA Gene

Genomic Location for CGA Gene

Chromosome:
6
Start:
87,085,498 bp from pter
End:
87,095,406 bp from pter
Size:
9,909 bases
Orientation:
Minus strand

Genomic View for CGA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CGA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGA Gene

Proteins for CGA Gene

  • Protein details for CGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01215-GLHA_HUMAN
    Recommended name:
    Glycoprotein hormones alpha chain
    Protein Accession:
    P01215

    Protein attributes for CGA Gene

    Size:
    116 amino acids
    Molecular mass:
    13075 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

    Three dimensional structures from OCA and Proteopedia for CGA Gene

neXtProt entry for CGA Gene

Proteomics data for CGA Gene at MOPED

Post-translational modifications for CGA Gene

  • Glycosylation at Asn 76 and Asn 102
  • Modification sites at PhosphoSitePlus

Other Protein References for CGA Gene

Antibody Products

  • R&D Systems Antibodies for CGA (Chorionic Gonadotropin alpha Chain (HCG alpha))

No data available for DME Specific Peptides for CGA Gene

Domains & Families for CGA Gene

Gene Families for CGA Gene

Graphical View of Domain Structure for InterPro Entry

P01215

UniProtKB/Swiss-Prot:

GLHA_HUMAN :
  • Belongs to the glycoprotein hormones subunit alpha family.
Family:
  • Belongs to the glycoprotein hormones subunit alpha family.
genes like me logo Genes that share domains with CGA: view

Function for CGA Gene

Molecular function for CGA Gene

GENATLAS Biochemistry:
glycoprotein hormones,alpha polypeptide,common to chorionic gonadotropin,FSH,LH,TSH

Gene Ontology (GO) - Molecular Function for CGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IMP 11207219
GO:0005515 protein binding IPI 11222739
genes like me logo Genes that share ontologies with CGA: view
genes like me logo Genes that share phenotypes with CGA: view

Animal Models for CGA Gene

MGI Knock Outs for CGA:

miRNA for CGA Gene

miRTarBase miRNAs that target CGA

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CGA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targets and HOMER Transcription for CGA Gene

Localization for CGA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CGA Gene COMPARTMENTS Subcellular localization image for CGA gene
Compartment Confidence
extracellular 5
nucleus 2
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005623 cell --
genes like me logo Genes that share ontologies with CGA: view

Pathways & Interactions for CGA Gene

genes like me logo Genes that share pathways with CGA: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

SIGNOR curated interactions for CGA Gene

Activates:

Gene Ontology (GO) - Biological Process for CGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006590 thyroid hormone generation --
GO:0007165 signal transduction TAS 481597
GO:0007267 cell-cell signaling TAS 481597
GO:0008284 positive regulation of cell proliferation NAS 20613903
GO:0008406 gonad development --
genes like me logo Genes that share ontologies with CGA: view

Drugs & Compounds for CGA Gene

(90) Drugs for CGA Gene - From: NovoSeek, ClinicalTrials, and ApexBio

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Cetuximab Approved Pharma EGFR Inhibitors, Therapeutic Antibodies, Epidermal growth factor receptor (EGFR) inhibitors 696
Fluorouracil Approved Pharma RNA processing inhibitor and thymidylate synthase inhibitor 1937
leucovorin Approved Pharma 922
Folic Acid Approved Nutra 2851
Anastrozole Approved, Investigational Pharma Aromatase inhibitor, Aromatase Inhibitors, Hormone therapy, Potent aromatase (CYP19) inhibitor 252

(56) Additional Compounds for CGA Gene - From: NovoSeek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
(+-)-pgf2-alpha
11 deoxycortisol
11-Ketotestosterone
17,20beta-Dihydroxy-4-pregnen-3-one
17alpha,20beta,21-Trihydroxy-4-pregnen-3-one
genes like me logo Genes that share compounds with CGA: view

Transcripts for CGA Gene

Unigene Clusters for CGA Gene

Glycoprotein hormones, alpha polypeptide:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CGA

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CGA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: -

Relevant External Links for CGA Gene

GeneLoc Exon Structure for
CGA
ECgene alternative splicing isoforms for
CGA

Expression for CGA Gene

mRNA expression in normal human tissues for CGA Gene

mRNA differential expression in normal tissues according to GTEx for CGA Gene

This gene is overexpressed in Pituitary (x52.6).

Protein differential expression in normal tissues from HIPED for CGA Gene

This gene is overexpressed in Placenta (65.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CGA Gene



SOURCE GeneReport for Unigene cluster for CGA Gene Hs.119689

genes like me logo Genes that share expression patterns with CGA: view

Protein tissue co-expression partners for CGA Gene

Primer Products

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CGA Gene

Orthologs for CGA Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGA Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CGA 35
  • 80 (n)
  • 71.67 (a)
CGA 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CGA 35
  • 83.89 (n)
  • 73.33 (a)
CGA 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cga 35
  • 76.39 (n)
  • 73.33 (a)
Cga 16
Cga 36
  • 73 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CGA 35
  • 98.64 (n)
  • 97.28 (a)
CGA 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cga 35
  • 76.11 (n)
  • 70.83 (a)
oppossum
(Monodelphis domestica)
Mammalia CGA 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CGA 36
  • 67 (a)
OneToOne
chicken
(Gallus gallus)
Aves CGA 35
  • 69.17 (n)
  • 69.17 (a)
CGA 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CGA 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cga 35
  • 66.67 (n)
  • 65.83 (a)
African clawed frog
(Xenopus laevis)
Amphibia tsha-A 35
zebrafish
(Danio rerio)
Actinopterygii cga 35
  • 65.2 (n)
  • 61.4 (a)
Dr.13896 35
cga 36
  • 56 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11927 35
Species with no ortholog for CGA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGA Gene

ENSEMBL:
Gene Tree for CGA (if available)
TreeFam:
Gene Tree for CGA (if available)

Paralogs for CGA Gene

No data available for Paralogs for CGA Gene

Variants for CGA Gene

Sequence variations from dbSNP and Humsavar for CGA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs6155 -- 87,088,186(-) TACAG(A/G)AAATA reference, synonymous-codon
rs6631 -- 87,085,541(-) GCATT(A/T)AGCTT utr-variant-3-prime
rs932742 -- 87,094,967(-) AGTAA(A/G)ATATT intron-variant
rs1055409 -- 87,085,592(-) TATCC(C/T)ACAGT utr-variant-3-prime
rs1983841 -- 87,090,167(+) TTCAC(A/T)CATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CGA Gene

Variant ID Type Subtype PubMed ID
nsv5385 CNV Loss 18451855
esv1002835 CNV Deletion 20482838

Variation tolerance for CGA Gene

Residual Variation Intolerance Score: 43.13% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CGA Gene

HapMap Linkage Disequilibrium report
CGA
Human Gene Mutation Database (HGMD)
CGA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGA Gene

Disorders for CGA Gene

MalaCards: The human disease database

(43) MalaCards diseases for CGA Gene - From: DISEASES, NovoSeek, and GeneCards

Disorder Aliases PubMed IDs
ectopic pregnancy
  • eccyesis
ovarian remnant syndrome
  • residual ovary syndrome
triploidy
  • chromosome triploidy syndrome
scalp dermatosis
  • dermatosis of scalp
mixed germ cell tumor
- elite association
Search CGA in MalaCards View complete list of genes associated with diseases

Relevant External Links for CGA

Genetic Association Database (GAD)
CGA
Human Genome Epidemiology (HuGE) Navigator
CGA
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CGA
genes like me logo Genes that share disorders with CGA: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CGA Gene

Publications for CGA Gene

  1. Premature progesterone elevation impairs implantation and live birth rates in GnRH-agonist IVF/ICSI cycles. (PMID: 19862542) KiliAsdag E.B. … Bagis T. (Arch. Gynecol. Obstet. 2010) 23 67
  2. Gonadotropin-regulated testicular RNA helicase (GRTH/DDX25) gene: cell-specific expression and transcriptional regulation by androgen in transgenic mouse testis. (PMID: 20108248) Tsai-Morris C.H. … Dufau M.L. (J. Cell. Biochem. 2010) 23 67
  3. Periovulatory expression of hyaluronan and proteoglycan link protein 1 (Hapln1) in the rat ovary: hormonal regulation and potential function. (PMID: 20339004) Liu J. … Jo M. (Mol. Endocrinol. 2010) 23 67
  4. Inhibitory effect of thyroid blocking antibody (TBAb) on the thyroid stimulatory effect of human chorionic gonadotropin (HCG) and equine chorionic gonadotropin (ECG). (PMID: 20351465) Ochi Y. … Hamaoki M. (Endocr. J. 2010) 23 67
  5. Insufficient luteinizing hormone-induced intracellular signaling disrupts ovulation in preovulatory follicles lacking estrogen receptor-{beta}. (PMID: 20378682) Rodriguez K.F. … Korach K.S. (Endocrinology 2010) 23 67

Products for CGA Gene

Sources for CGA Gene

Back to Top

Content