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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CGA Gene

protein-coding GIFtS: 66
GCID: GC06M087795

glycoprotein hormones, alpha polypeptide

Explore 155 diseases affiliated with
CGA via

MalaCards

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(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Glycoprotein Hormones, Alpha Polypeptide¹ ²		Luteinizing Hormone Alpha Chain² ³
FSHA¹ ²		Lutropin Alpha Chain² ³
GPHA1¹ ²		Thyroid-Stimulating Hormone Alpha Chain² ³
GPHa¹ ²		Thyrotropin Alpha Chain² ³
HCG¹ ²		FSH-Alpha¹
LHA¹ ²		LSH-Alpha¹
TSHA¹ ²		TSH-Alpha¹
Anterior Pituitary Glycoprotein Hormones Common Subunit Alpha² ³		CG-ALPHA²
Choriogonadotropin Alpha Chain² ³		Chorionic Gonadotropin, Alpha Polypeptide²
Chorionic Gonadotrophin Subunit Alpha² ³		Follicle-Stimulating Hormone Alpha Subunit²
Follicle-Stimulating Hormone Alpha Chain² ³		Glycoprotein Hormones Alpha Chain²
Follitropin Alpha Chain² ³		CG-Alpha¹

External Ids:	HGNC: 1885¹	Entrez Gene: 1081²	Ensembl: ENSG00000135346⁷	OMIM: 118850⁵	UniProtKB: P01215³

Export aliases for CGA gene to outside databases

Previous GC identifers: GC06M087741 GC06M087790 GC06M087851 GC06M085012

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CGA:

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating

hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are

associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique

and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the

glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this

gene. (provided by RefSeq, Nov 2011)

Gene Wiki entry for CGA (Chorionic gonadotropin alpha)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000006.11 NC_018917.1 NT_007299.13

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CGA gene promoter:
CREB AML1a deltaCREB En-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CGA promoter sequence

Search SABiosciences Chromatin IP Primers for CGA

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CGA

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 6q12-q21 Ensembl cytogenetic band: 6q14.3 HGNC cytogenetic band: 6q14-q21

CGA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CGA gene location

GeneLoc information about chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M087795: view genomic region (about GC identifiers)

Start:	87,795,216 bp from pter	End:	87,804,824 bp from pter
Size:	9,609 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: GLHA_HUMAN, P01215 (See protein sequence)

Recommended Name: Glycoprotein hormones alpha chain precursor

Size: 116 amino acids; 13075 Da

Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to

thyrotropin, lutropin, follitropin and gonadotropin

Subcellular location: Secreted

6/10 PDB 3D structures from and Proteopedia for CGA (see all 10):

1DZ7 (3D)

1E9J (3D)

1FL7 (3D)

1HCN (3D)

1HD4 (3D)

1HRP (3D)

Explore the universe of human proteins at neXtProt for CGA: NX_P01215

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P01215

CGA Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_000726.1 NP_001239312.1

ENSEMBL proteins:

ENSP00000358595

Reactome Protein details: P01215
Human Recombinant Protein Products:

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	Novus Biologicals CGA Proteins Novus Biologicals CGA Lysates
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	ProSpec Recombinant Protein for CGA
	Browse Proteins at Uscn

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005625	soluble fraction	--	--

CGA for ontologies About GeneDecksing

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Assay Products for CGA:

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	GenScript Custom Assay Services for CGA
	Browse Enzo Life Sciences for kits & assays
	Browse ELISAs and CLIAs at Uscn

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CGA for domains About GeneDecksing

1 InterPro domain/family:

IPR000476 Glyco_hormone

Graphical View of Domain Structure for InterPro Entry P01215

ProtoNet protein and cluster: P01215

2 Blocks protein families:

IPB000476 Glycoprotein hormones alpha chain

IPB002400 Growth factor cystine knot superfamily signature

UniProtKB/Swiss-Prot: GLHA_HUMAN, P01215

Similarity: Belongs to the glycoprotein hormones subunit alpha family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

Genatlas biochemistry entry for CGA:

glycoprotein hormones,alpha polypeptide,common to chorionic gonadotropin,FSH,LH,TSH

miRNA Products:		OriGene 3'-UTR Clone: CGA Browse MicroRNA Expression Plasmids
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Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CGA (see all 7) OriGene shRNA RFP: CGA OriGene siRNA: CGA
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CGA

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CGA

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		GenScript: all cDNA clones in your preferred vector: CGA (NM_000735)
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Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CGA
		Search LifeMap BioReagents cell lines for CGA

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGA

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	IEA	--
GO:0005515	protein binding	IPI	15662415

CGA for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Cga^tm1Sac for CGA
     5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cga):

endocrine/exocrine gland

growth/size

homeostasis/metabolism

nervous system

reproductive system

CGA for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/15 super-pathways (see all 15) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Glycoprotein hormones

	Glycoprotein hormones	1.00			Hormone ligand-binding receptors	0.33
	Peptide hormone biosynthesis	0.71

Class A/1 (Rhodopsin-like receptors)

	Class A/1 (Rhodopsin-like receptors)	1.00			Neuroactive ligand-receptor interaction	0.38
	GPCR ligand binding	0.75

Signaling by GPCR

	Signaling by GPCR	1.00			Signal Transduction	0.56
	GPCR downstream signaling	0.89

Transcription_Role of VDR in regulation of genes involved in osteoporosis

Transcription_Role of VDR in regulation of genes involved in osteoporosis

1.00

Transcription Role of VDR in regulation of genes involved in osteoporosis

0.80

PKA activation in glucagon signalling

Development_Role of Activin A in cell differentiation and proliferation

0.33

Development Role of Activin A in cell differentiation and proliferation

0.33

Pathway sources
See GeneCards unified pathways
Show all pathways

3 EMD Millipore Pathways for CGA

	Development Role of Activin A in cell differentiation and proliferation
	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Selected targets of GCR-alpha

1 Downloadable PowerPoint Slide of QIAGEN Pathway Central Maps for CGA

GnRH Signaling

2 GeneGo (Thomson Reuters) Pathways for CGA

	Transcription Role of VDR in regulation of genes involved in osteoporosis
	Development Role of Activin A in cell differentiation and proliferation

3 BioSystems Pathways for CGA

	FSH signaling pathway
	TSH signaling pathway
	Glucocorticoid receptor regulatory network

5/11 Reactome Pathways for CGA (see all 11)

	GPCR downstream signaling
	Peptide hormone biosynthesis
	Signaling by GPCR
	GPCR ligand binding
	Class A/1 (Rhodopsin-like receptors)

3 Kegg Pathways (Kegg details for CGA):

	Neuroactive ligand-receptor interaction
	GnRH signaling pathway
	Autoimmune thyroid disease

CGA for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CGA

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/28 Interacting proteins for CGA (P01215^{1, 2, 3} ENSP00000358595⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 28)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CGB	P01233²^,³, ENSP00000349954⁴	MINT-24926 I2D: score=5 STRING: ENSP00000349954
CGB5	P01233²^,³, ENSP00000301408⁴	MINT-24926 I2D: score=5 STRING: ENSP00000301408
CGB7	P01233²^,³, ENSP00000348545⁴	MINT-24926 I2D: score=5 STRING: ENSP00000348545
CGB8	P01233²^,³, ENSP00000347582⁴	MINT-24926 I2D: score=5 STRING: ENSP00000347582
PTPN12	Q05209²^,³	MINT-61770 I2D: score=3

About this table

Gene Ontology (GO): 5/16 biological process terms (GO ID links to tree view) (see all 16): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006590	thyroid hormone generation	IEA	--
GO:0007165	signal transduction	TAS	481597
GO:0007267	cell-cell signaling	TAS	481597
GO:0008284	positive regulation of cell proliferation	NAS	--
GO:0008406	gonad development	IEA	--

CGA for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CGA for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CGA

1 DrugBank Compound for CGA About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Alpha-D-Mannose	--	3458-28-4	target	--	--

10/138 Novoseek chemical compound relationships for CGA gene (see all 138) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
oestriol	86.8	86	9512261 (3), 1494541 (2), 8624312 (2), 1836960 (2) (see all 69)
progesterone	86.7	944	1761656 (6), 10997481 (6), 1379268 (6), 18492365 (6) (see all 99)
gnrh	86.1	417	8603601 (8), 17183101 (8), 17174489 (6), 7997235 (6) (see all 99)
clomiphene citrate	84.2	112	17070196 (4), 8567766 (3), 11775896 (3), 11595893 (3) (see all 52)
cetrorelix	80.8	25	15284212 (2), 10686191 (2), 15665010 (1), 11679500 (1) (see all 18)
estradiol	80.5	278	11497290 (6), 7951553 (4), 17031874 (4), 7819706 (3) (see all 99)
buserelin	79.1	45	16751622 (3), 7769051 (2), 8612858 (2), 18577353 (2) (see all 29)
testosterone	78.7	556	16751622 (7), 8075787 (6), 15562375 (6), 1601748 (6) (see all 99)
ganirelix	76.5	12	15916659 (1), 16037104 (1), 9572414 (1), 20101851 (1) (see all 10)
metrodin	72	7	8006130 (2), 7660716 (1), 10920087 (1), 2108196 (1) (see all 5)

Search CenterWatch for drugs/clinical trials and news about CGA / GLHA

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CGA gene (2 alternative transcripts):

NM_000735.3 NM_001252383.1

Unigene Cluster for CGA:

Glycoprotein hormones, alpha polypeptide

Hs.119689 [show with all ESTs]

Unigene Representative Sequence: AK023644

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000369582(uc021zci.1 uc003plj.2)

miRNA Products:		OriGene 3'-UTR Clone: CGA Browse OriGene MicroRNA Expression Plasmids
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Additional cDNA sequence:

AB019569.1 AK023644.1 AK311972.1 BC010957.1 BC020782.1 BC055080.1 CR457427.1 FJ624078.1

FJ624079.1 V00518.1

18 DOTS entries:

DT.91781433 DT.95152109 DT.100800521 DT.100855932 DT.95152115 DT.121386018 DT.91748275 DT.97772825

DT.100703812 DT.101985644 DT.121385758 DT.95152122 DT.100703816 DT.100703822 DT.121385745 DT.121385989

DT.91781405 DT.95152112

24/891 AceView cDNA sequences (see all 891):

BG623146 CD106061 CD239684 CR607107 CD242963 CD239122 CD239494 CR622170

CD239716 BG619066 CR615870 BX366877 CD238789 AU137688 CD107103 CD238209

CD238991 CD107913 CD251030 CD239545 H00683 AL547529 CD107356 BX355707

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CGA About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c
SP1:							-												-
SP2:							-						-						-
SP3:							-				-		-						-
SP4:							-						-
SP5:													-

ECgene alternative splicing isoforms for CGA

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CGA expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GGCTGCTGCT

About this image

CGA expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

3 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Placenta

Chorionic Villus

Syncytiotrophoblast Multinuclear Cells

Selective marker (cell-identifying gene)

Extraembryonic Tissues, Placenta

Trophoblast

Trophoblast Cells

Extraembryonic Tissues

Placenta

Chorionic Villus

Villous Cytotrophoblast Cells

Extraembryonic Tissues, Placenta

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 4 LifeMap Cells

Name

Category

Syncytiotrophoblast-like cells (Generation of syncyt...)

Trophoblast-like cells (Generation of tropho...)

Pancreatic endoderm/endocrine precursor-like cells (A scalable, suspensi...)

See CGA Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CGA

SOURCE GeneReport for Unigene cluster: Hs.119689

SABiosciences Expression via Pathway-Focused PCR Arrays including CGA:

cAMP / Ca2+ Signaling PathwayFinder in human mouse rat

Angiogenic Growth Factors in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CGA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CGA gene from 5/12 species (see all 12) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cga^{1 , 5}	glycoprotein hormones, alpha subunit^{1, 5}	78.45(n)¹ 75.86(a)¹		4 (16.86 cM)⁵ 12640¹ NM_009889.2¹ NP_034019.1¹ 34893779⁵
chicken (Gallus gallus)	Aves	CGA¹	glycoprotein hormones, alpha polypeptide	71.55(n) 72.41(a)		421829 XM_429886.3 XP_429886.2
lizard (Anolis carolinensis)	Reptilia	CGA⁶	--	72(a)	1 ↔ 1	1(176496928-176497068)
African clawed frog (Xenopus laevis)	Amphibia	tsha-A²	thyroid stimulating hormone alpha (TSH-alpha)	77.75(n)		L07619.1
zebrafish (Danio rerio)	Actinopterygii	Dr.13896²	Danio rerio gonadotropin alpha subunit mRNA, complete more	81.49(n)		AY424306.1

ENSEMBL Gene Tree for CGA (if available)
TreeFam Gene Tree for CGA (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 6 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs7740951^1,2	C,	--	85012152(+)	`ATGCTA/GTATTC`	1	--	ut3¹ ese³		0	--	--	--	--
rs4986870^1,2	F	--	85012189(-)	`CAGTAC/TAATCA`	1	--	ut3¹		5		MN	400
rs7741514^1,2	C,H,	--	85012641(+)	`CTCTAC/ACCCTA`	1	--	int¹		4		NS EA	416
rs9986555^1,2	C,F,H	--	85012934(+)	`CCTTAG/TTGGAG`	2	I L	mis¹ ese³		9		NS EA NA	1034
rs11380231^1,2	C	--	85013048(+)	`AAAAA-/AGGCAG`	1	--	int¹ trp³		0	--	--	--	--
rs113530868^1,2		--	85013753(+)	`TATGGG/CATAGT`	1	--	int¹		2		CSA WA	120
rs113592041^1,2	F,	--	85014396(+)	`CTGCCG/AGGAGA`	1	--	int¹		3		CSA WA	126
rs2274137^1,2	H	--	85014540(+)	`TGCACA/CTTTTC`	1	--	int¹		4		NS EA	420
rs10440806^1,2	A	--	85014980(+)	`TTTTTA/TAAAAA`	1	--	int¹		0	--	--	--	--
rs58447011^1,2	C,	--	85015015(+)	`ATAACT/CGAATC`	1	--	int¹		2		WA	120

HapMap Linkage Disequilibrium report for CGA (87795216 - 87804824 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CGA: --
Human Gene Mutation Database (HGMD): CGA

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CGA

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CGA for disorders           About GeneDecksing

OMIM gene information: 118850    OMIM disorders: --

20/155 diseases for CGA (see all 155):    About MalaCards

cutis marmorata telangiectatica congenita thyroiditis 5-alpha reductase deficiency androgen insensitivity syndrome

growth hormone secreting pituitary adenoma complete androgen insensitivity syndrome neural tube defect pineal region germinoma

placental site trophoblastic tumor scalp dermatosis bardet-biedl syndrome ectopic pregnancy

nephropathic cystinosis nonseminomatous germ cell tumor germ cell tumor gestational trophoblastic neoplasm

trophoblastic neoplasm luteoma endodermal sinus tumor sacrococcygeal teratoma

4 diseases from the University of Copenhagen DISEASES database for CGA:

Intermittent explosive disorder Scalp dermatosis Conduct disorder Borderline personality disorder

10/93 Novoseek disease relationships for CGA gene (see all 93) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian hyperstimulation syndrome	90.6	48	18238999 (2), 10221701 (1), 10966979 (1), 15807221 (1) (see all 40)
pregnancy tubal	83.7	48	2406662 (4), 9348261 (3), 7926077 (2), 9070731 (2) (see all 31)
down syndrome	80.7	241	10585342 (7), 17962101 (5), 19777489 (5), 7497141 (5) (see all 99)
pregnancy ectopic	80.2	103	7682316 (4), 1379268 (3), 10834324 (3), 1386659 (3) (see all 62)
infertility	79.2	70	10831544 (3), 12960071 (2), 18681993 (2), 11726579 (2) (see all 50)
trophoblastic disease	72.8	32	11263936 (3), 8563483 (2), 16189178 (2), 7510202 (2) (see all 17)
polycystic ovary syndrome	70.4	15	15734758 (2), 8476833 (1), 19146766 (1), 1901089 (1) (see all 14)
miscarriage	70	70	20464754 (6), 16225575 (5), 7947503 (4), 10834324 (4) (see all 35)
choriocarcinoma	69.7	52	1397383 (5), 17563738 (2), 10632747 (2), 2289629 (2) (see all 30)
hydatidiform mole	67.4	39	8157712 (4), 16638033 (3), 16189178 (3), 8906012 (3) (see all 18)

Human Genome Epidemiology (HuGE) Navigator: CGA (45 documents)

Export disorders for CGA gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CGA gene, integrated from 9 sources (see all 1840):
(articles sorted by number of sources associating them with CGA)

Utopia: connect your pdf to the dynamic
world of online information

The gene encoding the common alpha subunit of the four human glycoprotein hormones. (PubMed id 6286817)^{1, 2, 3} Fiddes J.C. and Goodman H.M. (1981)
Structure of human follicle-stimulating hormone in complex with its receptor. (PubMed id 15662415)^{1, 2} Fan Q.R. and Hendrickson W.A. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
NMR studies of the free alpha subunit of human chorionic gonadotropin. Structural influences of N-glycosylation and the beta subunit on the conformation of the alpha subunit. (PubMed id 8898911)^{1, 2} de Beer T.... Vliegenthart J.F.G. (1996)
Structure and regulation of human thyroid-stimulating hormone (TSH) gene. (PubMed id 8196184)^{1, 2} Miyoshi I.... Hayashizaki Y. (1994)
Crystal structure of human chorionic gonadotropin. (PubMed id 8202136)^{1, 2} Lapthorn A.J.... Isaacs N.W. (1994)
NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin. (PubMed id 1991473)^{1, 2} Weisshaar G.... Nimtz M. (1991)
The amino acid sequences of the prepeptides contained in the alpha and beta subunits of human choriogonadotropin. (PubMed id 7462224)^{1, 2} Birken S.... Boime I. (1981)
Studies on the disulfide bonds in human pituitary follicle- stimulating hormone. (PubMed id 6774759)^{1, 2} Fujiki Y.... Saxena B.B. (1980)
Assignment of disulfide bonds in the alpha subunit of human chorionic gonadotropin. (PubMed id 7410374)^{1, 2} Mise T. and Bahl O.P. (1980)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1081	HGNC: 1885	AceView: CGA	Ensembl:ENSG00000135346	euGenes: HUgn1081
ECgene: CGA	Kegg: 1081	H-InvDB: CGA

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CGA	Pharmacogenomics, SNPs, Pathways
Protein Spotlight	http://web.expasy.org/spotlight/back_issues/sptlt077.shtml

Intellectual Property for CGA gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CGA gene:
Search GeneIP for patents involving CGA

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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CGA Gene

glycoprotein hormones, alpha polypeptide

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CGA (Gene Symbol)
Glycoprotein Hormones, Alpha Polypeptide
FSHA
GPHA1
GPHa
HCG
LHA
TSHA
Anterior Pituitary Glycoprotein Hormones Common Subunit Alpha
Choriogonadotropin Alpha Chain
Chorionic Gonadotrophin Subunit Alpha
Follicle-Stimulating Hormone Alpha Chain
Follitropin Alpha Chain
Luteinizing Hormone Alpha Chain
Lutropin Alpha Chain
Thyroid-Stimulating Hormone Alpha Chain
Thyrotropin Alpha Chain
FSH-Alpha
LSH-Alpha
TSH-Alpha
CG-ALPHA
Chorionic Gonadotropin, Alpha Polypeptide
Follicle-Stimulating Hormone Alpha Subunit
Glycoprotein Hormones Alpha Chain
CG-Alpha

Down Syndrome
Pregnancy loss
Varicocele
preterm delivery
Infertility
Pituitary Dysfunction
Infertility Female
Azoospermia
Endometriosis
Ovarian Cysts
Puberty Delayed
Pregnancy Tubal
Turners Syndrome
Hyperthyroidism
ADNEXAL MASS
Dysgerminoma
HYPOTHYROIDISM PRIMARY
Seminoma
testicular teratoma
Klinefelters Syndrome
Pregnancy Abdominal
Micropenis
Hypopituitarism
Germ Cell Cancer
OVULATION INHIBITED
Miscarriage
Follicular Cyst
OVULATION DELAYED
Sex Chromosome Abnormalities
Luteoma
Hypospadias
Testicular Cancer
Kallmann Syndrome
Gynecomastia
Androgen Insensitivity Syndrome
Iodine deficiency
Trisomy
Tumors
Atresia
Preeclampsia
Anovulation
Abortion Threatened
Hyperandrogenism
Thyroiditis
Edwards syndrome
Hyperprolactinemia
PITUITARY ADENOMA
Germinoma
Prolactinoma
Abortion Missed
Hypothyroidism
VIRILIZATION
Trophoblastic Tumor Placental Site
Hemoperitoneum
Hydatidiform Mole
hypothalamic disorder
Miscarriage Recurrent
High-Risk Pregnancy
Endocrine Effects
Ovarian Hyperstimulation Syndrome
Neural Tube Defects
Anencephaly
Leydig Cell Tumor
Intrauterine Growth Retardation
Oligozoospermia
stage I testicular cancer
HEMATOSALPINX
PELVIC ADHESIONS
Granulosa Cell Tumor
Ovarian dysfunction
gestational trophoblastic disease
Testicular Diseases
Adenoma
Teratoma
Polycystic Ovary Syndrome
Thyroid Diseases
Puberty Precocious
Infertility Male
Trophoblastic disease
ovarian mixed germ cell tumor
Graves Disease
RUPTURED ECTOPIC PREGNANCY
Pregnancy Ectopic
Ovarian Diseases
Chromosomal Aberrations
Cryptorchidism
Carcinoma Embryonal
Trophoblastic Tumor
Cholera
Polycystic ovaries
Pregnancy Complications
Hypogonadism
Choriocarcinoma

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CGA Gene

glycoprotein hormones, alpha polypeptide

Aliasesfor CGA gene

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