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Aliases for CGA Gene

Aliases for CGA Gene

  • Glycoprotein Hormones, Alpha Polypeptide 2 3
  • Thyroid-Stimulating Hormone Alpha Chain 2 3 4
  • Luteinizing Hormone Alpha Chain 2 3 4
  • Lutropin Alpha Chain 2 3 4
  • Anterior Pituitary Glycoprotein Hormones Common Subunit Alpha 3 4
  • Follicle-Stimulating Hormone Alpha Subunit 2 3
  • Follicle-Stimulating Hormone Alpha Chain 3 4
  • Chorionic Gonadotrophin Subunit Alpha 3 4
  • Glycoprotein Hormones Alpha Chain 2 3
  • Choriogonadotropin Alpha Chain 3 4
  • Follitropin Alpha Chain 3 4
  • Thyrotropin Alpha Chain 3 4
  • FSH-Alpha 3 4
  • LSH-Alpha 3 4
  • TSH-Alpha 3 4
  • CG-ALPHA 3 4
  • Chorionic Gonadotropin, Alpha Polypeptide 3
  • Chorionic Gonadotropin 2
  • Alpha Polypeptide 2
  • GPHA1 3
  • FSHA 3
  • GPHa 3
  • TSHA 3
  • HCG 3
  • LHA 3

External Ids for CGA Gene

Previous GeneCards Identifiers for CGA Gene

  • GC06M087741
  • GC06M087790
  • GC06M087851
  • GC06M087795
  • GC06M085012

Summaries for CGA Gene

Entrez Gene Summary for CGA Gene

  • The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH), follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones are identical, however, their beta chains are unique and confer biological specificity. The protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha chain family. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

GeneCards Summary for CGA Gene

CGA (Glycoprotein Hormones, Alpha Polypeptide) is a Protein Coding gene. Diseases associated with CGA include anovulation and pineal region germinoma. Among its related pathways are Signaling by GPCR and Signaling by GPCR. GO annotations related to this gene include hormone activity.

Gene Wiki entry for CGA Gene

No data available for UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CGA Gene

Genomics for CGA Gene

Regulatory Elements for CGA Gene

Genomic Location for CGA Gene

Start:
87,085,498 bp from pter
End:
87,095,147 bp from pter
Size:
9,650 bases
Orientation:
Minus strand

Genomic View for CGA Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CGA Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CGA Gene

Proteins for CGA Gene

  • Protein details for CGA Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P01215-GLHA_HUMAN
    Recommended name:
    Glycoprotein hormones alpha chain
    Protein Accession:
    P01215
    Secondary Accessions:

    Protein attributes for CGA Gene

    Size:
    116 amino acids
    Molecular mass:
    13075 Da
    Quaternary structure:
    • Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.

    Three dimensional structures from OCA and Proteopedia for CGA Gene

neXtProt entry for CGA Gene

Proteomics data for CGA Gene at MOPED

Post-translational modifications for CGA Gene

  • Glycosylation at Asn76 and Asn102
  • Modification sites at PhosphoSitePlus

Other Protein References for CGA Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CGA (Chorionic Gonadotropin alpha Chain (alpha HCG))

No data available for DME Specific Peptides for CGA Gene

Domains for CGA Gene

Gene Families for CGA Gene

HGNC:

Graphical View of Domain Structure for InterPro Entry

P01215

UniProtKB/Swiss-Prot:

GLHA_HUMAN :
  • P01215
Family:
  • Belongs to the glycoprotein hormones subunit alpha family.
genes like me logo Genes that share domains with CGA: view

Function for CGA Gene

Molecular function for CGA Gene

GENATLAS Biochemistry: glycoprotein hormones,alpha polypeptide,common to chorionic gonadotropin,FSH,LH,TSH

Gene Ontology (GO) - Molecular Function for CGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005179 hormone activity IMP 11207219
GO:0005515 protein binding IPI 11222739
genes like me logo Genes that share ontologies with CGA: view
genes like me logo Genes that share phenotypes with CGA: view

Animal Models for CGA Gene

MGI Knock Outs for CGA:

miRNA for CGA Gene

miRTarBase miRNAs that target CGA

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CGA

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CGA Gene

Localization for CGA Gene

Subcellular locations from UniProtKB/Swiss-Prot for CGA Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CGA Gene COMPARTMENTS Subcellular localization image for CGA gene
Compartment Confidence
extracellular 5
nucleus 2
chloroplast 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
genes like me logo Genes that share ontologies with CGA: view

Pathways for CGA Gene

genes like me logo Genes that share pathways with CGA: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays

Gene Ontology (GO) - Biological Process for CGA Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006590 thyroid hormone generation --
GO:0007165 signal transduction TAS 481597
GO:0007267 cell-cell signaling TAS 481597
GO:0008284 positive regulation of cell proliferation NAS 20613903
GO:0008406 gonad development --
genes like me logo Genes that share ontologies with CGA: view

Compounds for CGA Gene

(1) Drugbank Compounds for CGA Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Alpha-D-Mannose
3458-28-4 target

(138) Novoseek inferred chemical compound relationships for CGA Gene

Compound -log(P) Hits PubMed IDs
oestriol 86.8 75
progesterone 86.7 313
gnrh 86.1 227
clomiphene citrate 84.2 74
cetrorelix 80.8 20
genes like me logo Genes that share compounds with CGA: view

Transcripts for CGA Gene

mRNA/cDNA for CGA Gene

Unigene Clusters for CGA Gene

Glycoprotein hormones, alpha polypeptide:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CGA

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CGA Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5a · 5b · 5c ^ 6a · 6b · 6c
SP1: - -
SP2: - - -
SP3: - - - -
SP4: - -
SP5: -

Relevant External Links for CGA Gene

GeneLoc Exon Structure for
CGA
ECgene alternative splicing isoforms for
CGA

Expression for CGA Gene

mRNA expression in normal human tissues for CGA Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CGA Gene

This gene is overexpressed in Pituitary (52.6).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CGA Gene

SOURCE GeneReport for Unigene cluster for CGA Gene Hs.119689

genes like me logo Genes that share expressions with CGA: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CGA Gene

Orthologs for CGA Gene

This gene was present in the common ancestor of chordates.

Orthologs for CGA Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CGA 35
  • 98.64 (n)
  • 97.28 (a)
CGA 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CGA 35
  • 80 (n)
  • 71.67 (a)
CGA 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CGA 35
  • 83.89 (n)
  • 73.33 (a)
CGA 36
  • 73 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cga 35
  • 76.39 (n)
  • 73.33 (a)
Cga 16
Cga 36
  • 73 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CGA 36
  • 75 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CGA 36
  • 67 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cga 35
  • 76.11 (n)
  • 70.83 (a)
chicken
(Gallus gallus)
Aves CGA 35
  • 69.17 (n)
  • 69.17 (a)
CGA 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CGA 36
  • 72 (a)
OneToOne
African clawed frog
(Xenopus laevis)
Amphibia tsha-A 35
tropical clawed frog
(Silurana tropicalis)
Amphibia cga 35
  • 66.67 (n)
  • 65.83 (a)
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.11927 35
zebrafish
(Danio rerio)
Actinopterygii cga 35
  • 65.2 (n)
  • 61.4 (a)
cga 36
  • 56 (a)
OneToOne
Dr.13896 35
Species with no ortholog for CGA:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CGA Gene

ENSEMBL:
Gene Tree for CGA (if available)
TreeFam:
Gene Tree for CGA (if available)

Paralogs for CGA Gene

No data available for Paralogs for CGA Gene

Variants for CGA Gene

Sequence variations from dbSNP and Humsavar for CGA Gene

SNP ID Clin Chr 06 pos Sequence Context AA Info Type MAF
rs6155 -- 87,088,186(-) TACAG(A/G)AAATA reference, synonymous-codon
rs6631 -- 87,085,541(-) GCATT(A/T)AGCTT utr-variant-3-prime
rs932742 -- 87,094,967(-) AGTAA(A/G)ATATT intron-variant
rs1055409 -- 87,085,592(-) TATCC(C/T)ACAGT utr-variant-3-prime
rs1983841 -- 87,090,167(+) TTCAC(A/T)CATAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CGA Gene

Variant ID Type Subtype PubMed ID
nsv5385 CNV Loss 18451855
esv1002835 CNV Deletion 20482838

Relevant External Links for CGA Gene

HapMap Linkage Disequilibrium report
CGA
Human Gene Mutation Database (HGMD)
CGA

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CGA Gene

Disorders for CGA Gene

MalaCards: The human disease database

MalaCards: The human disease database. (46) Diseases for CGA Gene including...

Search for CGA Gene in MalaCards »

(93) Novoseek inferred disease relationships for CGA Gene

Disease -log(P) Hits PubMed IDs
ovarian hyperstimulation syndrome 90.6 41
pregnancy tubal 83.7 42
down syndrome 80.7 168
pregnancy ectopic 80.2 87
infertility 79.2 56

Relevant External Links for CGA

Genetic Association Database (GAD)
CGA
Human Genome Epidemiology (HuGE) Navigator
CGA
genes like me logo Genes that share disorders with CGA: view

No data available for UniProtKB/Swiss-Prot for CGA Gene

Publications for CGA Gene

  1. The gene encoding the common alpha subunit of the four human glycoprotein hormones. (PMID: 6286817) Fiddes J.C. … Goodman H.M. (J. Mol. Appl. Genet. 1981) 2 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. Studies on the disulfide bonds in human pituitary follicle- stimulating hormone. (PMID: 6774759) Fujiki Y. … Saxena B.B. (Biochim. Biophys. Acta 1980) 3 4
  4. Assignment of disulfide bonds in the alpha subunit of human chorionic gonadotropin. (PMID: 7410374) Mise T. … Bahl O.P. (J. Biol. Chem. 1980) 3 4
  5. The amino acid sequences of the prepeptides contained in the alpha and beta subunits of human choriogonadotropin. (PMID: 7462224) Birken S. … Boime I. (J. Biol. Chem. 1981) 3 4

Products for CGA Gene

Sources for CGA Gene

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