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CGA Gene

protein-coding GIFtS: 68

GC06M087851

glycoprotein hormones, alpha polypeptide
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CG-ALPHA ^²
CG-alpha ^³
FSH-alpha ^³
FSHA ^¹, ²
GPHA1 ^¹, ²
GPHa ^¹, ²
HCG ^¹, ²
LHA ^¹, ²
LSH-alpha ^³
OTTHUMP00000016825 ^²
TSH-alpha ^³
TSHA ^¹, ²

Descriptions
Anterior pituitary glycoprotein hormones common subunit alpha ^³
Choriogonadotropin alpha chain ^³
Chorionic gonadotrophin subunit alpha ^³
Follicle-stimulating hormone alpha chain ^³
Follitropin alpha chain ^³
Luteinizing hormone alpha chain ^³
Lutropin alpha chain ^³
Thyroid-stimulating hormone alpha chain ^³
Thyrotropin alpha chain ^³
chorionic gonadotropin, alpha polypeptide ^²
follicle-stimulating hormone alpha subunit ^²
glycoprotein hormones, alpha polypeptide ^²

External Ids
HGNC: 1885¹
Entrez Gene: 1081²
UniProtKB: P01215³
Ensembl: ENSG00000135346⁷

Search outside databases for aliases for CGA gene

Previous GC identifers: GC06M087741 GC06M087790

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

EntrezGene summary for CGA:

The four human glycoprotein hormones chorionic gonadotropin (CG), luteinizing hormone (LH),

follicle stimulating hormone (FSH), and thyroid stimulating hormone (TSH) are dimers consisting of

alpha and beta subunits that are associated noncovalently. The alpha subunits of these hormones

are identical, however, their beta chains are unique and confer biological specificity. The

protein encoded by this gene is the alpha subunit and belongs to the glycoprotein hormones alpha

chain family. [provided by RefSeq]

Gene Wiki entry for CGA (Chorionic_gonadotropin_alpha)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CGA gene

Entrez Gene cytogenetic band: 6q12-q21 Ensembl cytogenetic band: 6q15 HGNC cytogenetic band: 6q14-q21

CGA Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 6 GeneLoc Exon Structure

GeneLoc location for GC06M087851: (about GC identifiers)

Start:	87,851,935 bp from pter
End:	87,861,569 bp from pter
Size:	9,635 bases
Orientation:	minus strand

RefSeq DNA sequence:

NC_000006.10 NT_007299.12

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: GLHA_HUMAN, P01215 (See protein sequence)

Recommended Name: Glycoprotein hormones alpha chain precursor

Size: 116 amino acids; 13075 Da

Subunit: Heterodimer of a common alpha chain and a unique beta chain which confers biological

specificity to thyrotropin, lutropin, follitropin and gonadotropin

Subcellular location: Secreted

PDB structures from and Proteopedia :

1DZ7 (3D)

1E9J (3D)

1FL7 (3D)

1HCN (3D)

1HD4 (3D)

1HRP (3D)

1QFW (3D)

1XUL (3D)

1XWD (3D)

Post-translational modifications:

View phosphorylation sites using PhosphoSite²

REFSEQ proteins: NP_000726.1

ENSEMBL proteins:

ENSP00000358595

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich Proteins for CGA
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (hCG alpha 2, hCG alpha, TSH, hCG alpha 6, hCG alpha 3, Glycoprotein hormones (alpha 5), Luteinizing Hormone alpha, FSH, hCG alpha 4, TSH alpha , hCG alpha + beta)
	Human Recombinant Proteins from Abnova (CGA)

Browse Origene for full length recombinant human proteins expressed in human HEK293 cells

2 Gene Ontology (GO) cellular component terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--
GO:0005625	soluble fraction	TAS	481597

About this table

Antibodies for CGA:

	Browse Antibodies Central at Invitrogen
	Browse Millipore's Extensive Line of Mono- and Polyclonal Antibodies
	Sigma-Aldrich Antibodies for CGA
	R&D Systems Antibodies for CGA (alpha HCG)
	Antibodies from Abcam (hCG alpha 2, hCG alpha, TSH, hCG alpha 6, hCG alpha 3, Glycoprotein hormones (alpha 5), FSH, Luteinizing Hormone alpha, hCG alpha 4, TSH alpha , hCG alpha + beta), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CGA)
	Novus Biologicals Antibodies for CGA

Assays for CGA:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry P01215

ProtoNet protein and cluster: P01215

2 Blocks protein families:

IPB000476 Glycoprotein hormones alpha chain

IPB002400 Growth factor cystine knot superfamily signature

UniProtKB/Swiss-Prot: GLHA_HUMAN, P01215

Similarity: Belongs to the glycoprotein hormones subunit alpha family

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CGA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CGA)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000735

Applied Biosystems Silencer® siRNAs for CGA

Sigma-Aldrich siRNA for CGA

Sigma-Aldrich shRNA for CGA

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CGA
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clone in CMV expression vector: NM_000735
Myc/DDK tagged cDNA clone in CMV expression vector: NM_000735
untagged cDNA clone in CMV expression vector: NM_000735

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_000735

Genatlas biochemistry entry for CGA:

glycoprotein hormones,alpha polypeptide,common to chorionic gonadotropin,FSH,LH,TSH

5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Cga):

endocrine/exocrine gland

growth/size

homeostasis/metabolism

nervous system

reproductive system

1 Gene Ontology (GO) molecular function term (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005179	hormone activity	TAS	481597

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

1 Sigma-Aldrich "Your Favorite Gene" Pathway for CGA (Your Favorite Gene powered by Ingenuity)

Autoimmune Thyroid Disease Signaling

GeneDecks CGA for the pathways selected above

About GeneDecksing

Gene Network Central^TM Interacting Genes and Proteins Network for CGA

5/72 Interacting proteins for CGA (P01215² ENSP00000358595³) via UniProtKB, MINT, and/or STRING (see all 72 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
CGB	P01233², ENSP00000349954³	MINT-24926 STRING (score=.999)
CGB5	P01233², ENSP00000301408³	MINT-24926 STRING (score=.999)
CGB7	P01233², ENSP00000366493³	MINT-24926 STRING (score=.717)
CGB8	P01233²	MINT-24926
PTPN12	Q05209²	MINT-61770

About this table

5/10 Gene Ontology (GO) biological process terms (links to tree view) (see all 10 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006590	thyroid hormone generation	IEA	--
GO:0007165	signal transduction	TAS	481597
GO:0007267	cell-cell signaling	TAS	481597
GO:0008406	gonad development	IEA	--
GO:0030878	thyroid gland development	IEA	--

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CGA
10/38 Novoseek chemical compound relationships for CGA gene (see all 38 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
oestriol	86.83	82	9512261 (3), 1494541 (2), 1836960 (2), 8624312 (2) (see all 66)
progesterone	86.57	908	1761656 (6), 10997481 (6), 1379268 (6), 18492365 (6) (see all 99)
estradiol	80.24	268	11497290 (6), 7951553 (4), 17031874 (4), 7819706 (3) (see all 99)
17alpha,20beta,21-trihydroxy-4-pregnen-3-one	68.40	2	11825028 (1), 2354768 (1)
androstenedione	66.59	26	12812264 (2), 10726907 (2), 1561629 (2), 1388313 (1) (see all 20)
3beta-hydroxysteroid	63.79	13	11098016 (1), 1402535 (1), 8714008 (1), 17412805 (1) (see all 11)
17-hydroxyprogesterone	60.30	25	9262268 (4), 16580856 (2), 1561629 (2), 10717816 (1) (see all 16)
steroid	58.97	79	10611255 (3), 10499535 (2), 11825028 (2), 12801577 (2) (see all 58)
17,20beta-dihydroxy-4-pregnen-3-one	55.43	2	2354768 (1), 2307341 (1)
ribonucleic acid	53.84	9	7989473 (1), 1309346 (1), 8027246 (1), 7775647 (1) (see all 7)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CGA)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CGA)

OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000735

Sigma-Aldrich siRNA for CGA

Sigma-Aldrich shRNA for CGA

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_000735

REFSEQ mRNAs for CGA gene:

NM_000735.2

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_000735

              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000735
                                 Myc/DDK tagged cDNA clone in CMV expression vector: NM_000735
                                 untagged cDNA clone in CMV expression vector: NM_000735

Additional cDNA sequence:

AB019569.1 AK023644.1 AK311972.1 BC010957.1 BC020782.1 BC055080.1 CR457427.1 CR591068.1

CR591147.1 CR595519.1 CR596397.1 CR598298.1 CR599056.1 CR602651.1 CR607107.1 CR610488.1

CR611195.1 CR611908.1 CR615870.1 CR616045.1 CR622170.1 CR626155.1 FJ624078.1 FJ624079.1

V00518.1

18 DOTS entries:

DT.91781433 DT.95152109 DT.100800521 DT.100855932 DT.95152115 DT.121386018 DT.91748275 DT.100703812

DT.97772825 DT.101985644 DT.121385758 DT.95152122 DT.100703816 DT.100703822 DT.121385745 DT.121385989

DT.91781405 DT.95152112

24/891 AceView cDNA sequences (see all 891 ):

CD242963 CD239717 CD106061 CD106975 CD251030 CD251589 BG435360 CD107356

BG572887 CD250906 CD238220 AA369238 W86567 R71429 CD517981 CD238209

CD239131 AU137688 CD238991 CD238306 BG621386 BG623146 CD239545 BG572343

highest scoring ESTs for CGA:

AA092161 AA369238 AI189849 AL550768 AL550786 AL552276 AL554137 AL554275 AU134687 AU134698

Unigene Cluster for CGA:

Glycoprotein hormones, alpha polypeptide

Hs.119689 [show with all ESTs]

Unigene Representative Sequence: AK023644

GeneLoc Exon Structure

5 Alternative Splicing Database (ASD) splice patterns (SP) for CGA

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5a	·	5b	·	5c	^	6a	·	6b	·	6c
SP1:							-												-
SP2:							-						-						-
SP3:							-				-		-						-
SP4:							-						-
SP5:													-

About this scheme

ECgene alternative splicing isoforms for CGA

1 Ensembl transcript including schematic representation:

ENST00000369582

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CGA expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CGA

¹ / ² / ³

5 probe-sets matching CGA gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
39352_at²^{, 3}	U95-A	1	1.00	1.00	1.00	1.00	S70585	0.20	1.00	0.72	1
204637_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_000735	0.60	1.00	0.82	1
233615_at*²^{, 3}	U133-B	1	1.00	1.00	--	--	AU157698	0.20	1.00	0.72	1
204637_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
233615_at*²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--

GeneDecks CGA for binary patterns associated with the probe-sets selected above

About GeneDecksing

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Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GGCTGCTGCT

SOURCE GeneReport for Unigene cluster: Hs.119689
Expression variation in blood from EXPOLDB for CGA

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CGA gene from 5/9 species (see all 9 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CGA¹	--	glycoprotein hormones, alpha polypeptide	85.92(n) 75.86(a)	403483 NM_001002988.1 NP_001002988.1
chimpanzee (Pan troglodytes)	CGA¹	--	glycoprotein hormones, alpha polypeptide	98.28(n) 96.55(a)	462868 XM_001153242.1 XP_001153242.1
cow (Bos taurus)	CGA¹	--	glycoprotein hormones, alpha polypeptide	81.9(n) 74.14(a)	280749 NM_173901.1 NP_776326.1
rat (Rattus norvegicus)	Cga¹	--	glycoprotein hormones, alpha subunit	77.3(n) 74.14(a)	116700 NM_053918.1 NP_446370.1
mouse (Mus musculus)	Cga^{1, 5}	4 (10.50 cM)⁵	glycoprotein hormones, alpha subunit^{1, 5}	78.45(n)¹ 75.86(a)¹	12640¹ NM_009889.2¹ NP_034019.1¹ AF307151⁵ AL929565⁵ (see all 11)

About this table Species with no ortholog for CGA

ENSEMBL Gene Tree for CGA

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/101 NCBI SNPs in CGA are shown (see all 101 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 64)

AB	SNP ID	Valid	Chr 6 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
	rs1055409^1,2	A,C,F,H,O	87852029(-)	`TATCCT/CACAGT`	1	--	ut3¹ ese³		21		MN CSAM EA NA EU WA	1924
	rs6631^1,2	A,C,F,H	87851978(-)	`GCATTT/AAGCTT`	1	--	ut3¹		19		MN CSAM EA NA EU WA	1738
	rs4706287^1,2	A,C,F,H	87863215(+)	`TTTACG/ATACTG`	1	--	ng3¹		4		EU EA WA	374
	rs2242602^1,2	A,C,F,H	87861929(-)	`GGAAAT/AGCTCT`	1	--	ng3¹		8		EA NA EU WA	1856
	rs3828759^1,2	A,C,F,H	87863359(-)	`AGAGTA/GTCTGC`	1	--	ng3¹		12		EU EA WA NA	1054
	rs2031365^1,2	A,C,F,H	87862311(+)	`TACTCC/TGCTCA`	1	--	ng3¹		4		EU EA WA	412
	rs9344675^1,2	C,F,H	87862004(+)	`AAAATT/GAATTT`	1	--	ng3¹ tfbs³		7		NA EU EA WA	522
	rs4986869^1,2	C,F,H	87851900(-)	`AAGCCA/GGTTGC`	1	--	ng5¹		9		MN CSAM EA EU WA	810
--	rs2031366^1,2	A,C	87862609(+)	`ctgtcG/Tcccaa`	1	--	ng3¹		0	--	--	--	--
	rs9986555^1,2	H	87852767(+)	`CCTTAG/TTGGAG`	1	L/I	mis¹ ese³		4		EU EA WA	418

About this table

HapMap Linkage Disequilibrium images for CGA (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
About This Section

OMIM: 118850

10/93 Novoseek disease relationships for CGA gene (see all 93 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
ovarian hyperstimulation syndrome	90.00	44	18238999 (2), 10221701 (1), 10966979 (1), 15807221 (1) (see all 36)
pregnancy tubal	83.55	45	2406662 (4), 9348261 (3), 7926077 (2), 9070731 (2) (see all 29)
down syndrome	80.89	231	10585342 (7), 17962101 (5), 7497141 (5), 7518896 (4) (see all 99)
pregnancy ectopic	80.07	98	7682316 (4), 1379268 (3), 10834324 (3), 1386659 (3) (see all 59)
infertility	78.80	65	10831544 (3), 12960071 (2), 18681993 (2), 11726579 (2) (see all 47)
trophoblastic disease	73.43	32	11263936 (3), 8563483 (2), 16189178 (2), 7510202 (2) (see all 17)
choriocarcinoma	69.72	49	1397383 (5), 17563738 (2), 10632747 (2), 2289629 (2) (see all 29)
polycystic ovary syndrome	69.31	15	15734758 (2), 8476833 (1), 19146766 (1), 1901089 (1) (see all 14)
spontaneous abortion	68.97	61	16225575 (5), 7947503 (4), 10834324 (4), 8319370 (3) (see all 32)
hydatidiform mole	67.81	38	8157712 (4), 16638033 (3), 16189178 (3), 8906012 (3) (see all 17)

About this table

Human Genome Epidemiology Navigator: CGA (22 documents)

(Possibly Related Articles in Doctor's Guide)
About This Section

Aging Population Presents Unique Challenges for Oncology Nurses, but Emerging Tools Will Help With Treatment Stratification: Presented at ONS

(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
About This Section

10/1359 PubMed articles for CGA gene (see all 1359 ):

The gene encoding the common alpha subunit of the four human glycoprotein hormones. (PubMed id 6286817)^{2, 3, 4} Fiddes J.C. and Goodman H.M. (1981)
Structure of human follicle-stimulating hormone in complex with its receptor. (PubMed id 15662415)^{3, 4} Fan Q.R. and Hendrickson W.A. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
NMR studies of the free alpha subunit of human chorionic gonadotropin. Structural influences of N-glycosylation and the beta subunit on the conformation of the alpha subunit. (PubMed id 8898911)^{3, 4} de Beer T.... Vliegenthart J.F.G. (1996)
Structure and regulation of human thyroid-stimulating hormone (TSH) gene. (PubMed id 8196184)^{3, 4} Miyoshi I.... Hayashizaki Y. (1994)
Crystal structure of human chorionic gonadotropin. (PubMed id 8202136)^{3, 4} Lapthorn A.J.... Isaacs N.W. (1994)
NMR investigations of the N-linked oligosaccharides at individual glycosylation sites of human lutropin. (PubMed id 1991473)^{3, 4} Weisshaar G.... Nimtz M. (1991)
The amino acid sequences of the prepeptides contained in the alpha and beta subunits of human choriogonadotropin. (PubMed id 7462224)^{3, 4} Birken S.... Boime I. (1981)
Studies on the disulfide bonds in human pituitary follicle- stimulating hormone. (PubMed id 6774759)^{3, 4} Fujiki Y.... Saxena B.B. (1980)
Assignment of disulfide bonds in the alpha subunit of human chorionic gonadotropin. (PubMed id 7410374)^{3, 4} Mise T. and Bahl O.P. (1980)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
About This Section

Entrez Gene: 1081	HGNC: 1885	AceView: CGA	Ensembl:ENSG00000135346	euGenes: HUgn1081
ECgene: CGA	H-InvDB: CGA

(According to HUGE)
About This Section

(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
Mammary Transgene Database entry for CGA	More genetic and clinical information
Protein Spotlight	http://www.expasy.org/spotlight/back_issues/sptlt077.shtml

Licensable Technologies for CGA
(Available from WIS Yeda, Salk, Tufts)

About This Section

(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
About This Section

Products for CGA:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CGA-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

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	Recombinant Proteins (hCG alpha 2, hCG alpha, TSH, hCG alpha 6, hCG alpha 3, Glycoprotein hormones (alpha 5), FSH, Luteinizing Hormone alpha, hCG alpha 4, TSH alpha , hCG alpha + beta)
	Antibodies (hCG alpha 2, hCG alpha, TSH, hCG alpha 6, hCG alpha 3, Glycoprotein hormones (alpha 5), FSH, Luteinizing Hormone alpha, hCG alpha 4, TSH alpha , hCG alpha + beta)

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

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CGA Gene

protein-coding GIFtS: 68

Aliases &
Descriptions
for CGA

Summaries
for CGA

Genomic Location
for CGA

Proteins
for CGA

Protein Domains/
Families
for CGA

Gene Function
for CGA

Pathways & Interactions
for CGA

Drugs & Compounds
for CGA

Transcripts
for CGA

Expression
for CGA

Orthologs
for CGA

Paralogs
for CGA

SNPs/Variants
for CGA

Disorders & Mutations
for CGA

Medical News
for CGA

Publications
for CGA

Search for CGA

Genome Databases showing CGA

Other Databases showing CGA

Specialized Databases showing CGA

Licensable Technologies
for CGA

Services
for CGA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CGA (Gene Symbol)
CG-ALPHA
CG-alpha
FSH-alpha
FSHA
GPHA1
GPHa
HCG
LHA
LSH-alpha
OTTHUMP00000016825
TSH-alpha
TSHA
Anterior pituitary glycoprotein hormones common subunit alpha
Choriogonadotropin alpha chain
Chorionic gonadotrophin subunit alpha
Follicle-stimulating hormone alpha chain
Follitropin alpha chain
Luteinizing hormone alpha chain
Lutropin alpha chain
Thyroid-stimulating hormone alpha chain
Thyrotropin alpha chain
chorionic gonadotropin, alpha polypeptide
follicle-stimulating hormone alpha subunit
glycoprotein hormones, alpha polypeptide

CGA Gene

protein-coding GIFtS: 68

Aliases & Descriptionsfor CGA

Summariesfor CGA

Genomic Locationfor CGA

Proteinsfor CGA

Protein Domains/Familiesfor CGA

Gene Functionfor CGA

Pathways & Interactionsfor CGA

Drugs & Compoundsfor CGA

Transcriptsfor CGA

Expression for CGA

Orthologsfor CGA

Paralogsfor CGA

SNPs/Variantsfor CGA

Disorders & Mutationsfor CGA

Medical Newsfor CGA

Publicationsfor CGA

Search for CGA

Genome Databases showing CGA

Other Databases showing CGA

Specialized Databases showing CGA

Licensable Technologiesfor CGA

Servicesfor CGA

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CGA

Summaries
for CGA

Genomic Location
for CGA

Proteins
for CGA

Protein Domains/
Families
for CGA

Gene Function
for CGA

Pathways & Interactions
for CGA

Drugs & Compounds
for CGA

Transcripts
for CGA

Expression
for CGA

Orthologs
for CGA

Paralogs
for CGA

SNPs/Variants
for CGA

Disorders & Mutations
for CGA

Medical News
for CGA

Publications
for CGA

Licensable Technologies
for CGA

Services
for CGA