CFTR Gene

Aliases &
Descriptions
for CFTR

Previous GC identifers: GC07P115597 GC07P116660 GC07P116674 GC07P116713

Summaries
for CFTR

Gene Wiki entry for CFTR (Cystic_fibrosis_transmembrane_conductance_regulator)

Genomic Location
for CFTR

Proteins
for CFTR

PDB structures from and Proteopedia :

1NBD (3D)    1XMI (3D)    1XMJ (3D)    2BBO (3D)    2BBS (3D)    2BBT (3D)    2PZE (3D)    2PZF (3D)    

2PZG (3D)    

Post-translational modifications:

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Sigma-Aldrich CompoZr ZFN for CFTR
	Browse R&D Systems for human recombinant proteins
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (CFTR)
	Human Recombinant Proteins from Abnova (CFTR)

5 Gene Ontology (GO) cellular component terms (links to tree view):

	Browse Antibodies Central at Invitrogen
	Millipore Mono- and Polyclonal Antibodies for the study of CFTR
	Sigma-Aldrich Antibodies for CFTR
	R&D Systems Antibodies for CFTR
	Cell Signaling Technology (CST) Antibodies for CFTR
	Antibodies from Abcam (CFTR), each with their AbpromiseSM
	Monoclonal and Polyclonal Antibodies from Abnova (CFTR)
	Novus Biologicals Antibodies for CFTR

	Browse Invitrogen for biochemical assays
	Millipore Kits and Assays for the Analysis of CFTR
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

Protein Domains/
Families
for CFTR

5/7 InterPro domains/families (see all 7 ):

IPR003439 ABC_transporter-like  IPR005291 cAMP_cl_channel  IPR017940 ABC_transporter_type1  IPR017871 ABC_transporter_CS  IPR001140 ABC_TM_transpt    GeneDecks  CFTR for the domains selected above   About GeneDecksing

Graphical View of Domain Structure for InterPro Entry P13569

ProtoNet protein and cluster: P13569

Gene Function
for CFTR

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CFTR)
		Millipore RNAi Products for the Analysis of CFTR Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CFTR)

Clones:		Browse Clone Ranger at Invitrogen for clones
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

5/9 Gene Ontology (GO) molecular function terms (links to tree view) (see all 9 ):

Pathways & Interactions
for CFTR

2 Millipore Pathways for CFTR

Selected targets of CREB1  Selected targets of HNF1    GeneDecks  CFTR for the pathways selected above   About GeneDecksing

2 Kegg Pathways  (Kegg details for CFTR):

hsa02010 ABC transporters  hsa05110 Vibrio cholerae infection    GeneDecks  CFTR for the pathways selected above   About GeneDecksing

5/12 Gene Ontology (GO) biological process terms (links to tree view) (see all 12 ):

Drugs & Compounds
for CFTR

Transcripts
for CFTR

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CFTR)
		Millipore RNAi Products for the Analysis of CFTR Gene knock-down
		Abnova Chimera RNAi Products for Gene knock-down (CFTR)

Applied Biosystems Silencer® siRNAs: 

REFSEQ mRNAs for CFTR gene: 

Applied Biosystems TaqMan ® Gene Expression Assays: 

Expression
for CFTR

CFTR expression in normal and diseased human tissues

 Applied Biosystems TaqMan ® Gene Expression Assays for CFTR

¹ / ² / ³

11 probe-sets matching CFTR gene

	Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
			# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
	36816_s_at2, 3	U95-A	1	1.00	1.00	0.97	1.41	M28668	1.00	1.00	1.00	1
	31578_at*2, 3	U95-A	1	--	--	0.95	0.66	M96936	0.20	1.00	0.72	1
	36817_at*2, 3	U95-A	1	--	--	0.52	0.40	M55131	0.20	1.00	0.72	1
	215702_s_at2, 3	U133-A	1	1.00	1.00	--	--	W60595	0.40	1.00	0.76	1
	234702_x_at2, 3	U133-B	1	1.00	1.00	--	--	S64699	0.60	1.00	0.82	1
	205043_at2, 3	U133-A	1	1.00	1.00	--	--	NM_000492	0.60	1.00	0.82	1
	217026_at*2, 3	U133-A	NULL	0.00	0.00	--	--	M96936	0.20	1.00	0.72	1
	215702_s_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
	234702_x_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
	205043_at2	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
	217026_at*2	U133Plus2	NULL	0.00	0.00	--	--	--	--	--	--	--

GeneDecks  CFTR for binary patterns associated with the probe-sets selected above   About GeneDecksing

About this table    

GNF BioGPS
    About these images
About these images

CGAP SAGE TAG: CCAACTAGAA

SOURCE GeneReport for Unigene clusters: Hs.489786 Hs.621460 Hs.661104

Expression variation in blood from EXPOLDB for CFTR

UniProtKB/Swiss-Prot: CFTR_HUMAN, P13569

Tissue specificity: Found on the surface of the epithelial cells that line the lungs and other

organs

Orthologs
for CFTR

Paralogs
for CFTR

Paralogs for CFTR gene

ABCC10²  ABCC8²  ABCC9²  

SNPs/Variants
for CFTR

Disorders & Mutations
for CFTR

UniProtKB/Swiss-Prot: CFTR_HUMAN, P13569

Medical News
for CFTR

• Cystic Fibrosis Gene Protects Against Typhoid Fever
• Cystic Fibrosis Transmembrane Regulator Gene Linked to Higher Risk of Pancreatic Cancer: Presented at ASCO-GI
• Protein Fragments May Help Alleviate Cystic Fibrosis
• Gene Therapy Can Help Improve Cystic Fibrosis
• PTC Therapeutics Announces Positive Phase 2 Results for PTC124 in Cystic Fibrosis
• ICPP: Link Found Between Class II Cystic Fibrosis Mutations and Severity of Pancreatic Disease in Cystic Fibrosis Patients

Publications
for CFTR

• The role of CFTR and SPINK-1 mutations in pancreatic disorders in HIV-positive patients: a case-control study. (PubMed id 15238770)^{1, 3, 6} Felley C....Frossard J.L. (2004)
• Complete cystic fibrosis transmembrane conductance regulator gene sequencing in patients with idiopathic chronic pancreatitis and controls. (PubMed id 15987793)^{1, 3, 6} Weiss F.U....Lerch M.M. (2005)
• Myosin VI regulates endocytosis of the cystic fibrosis transmembrane conductance regulator. (PubMed id 15247260)^{1, 3, 4} Swiatecka-Urban A.... Stanton B.A. (2004)
• The cystic fibrosis transmembrane conductance regulator interacts with and regulates the activity of the HCO3- salvage transporter human Na+-HCO3-cotransport isoform 3. (PubMed id 12403779)^{1, 3, 4} Park M.... Kurtz I. (2002)
• Analysis of cystic fibrosis transmembrane conductance regulator gene mutations in patients with congenital absence of the uterus and vagina. (PubMed id 12794695)^{1, 3, 6} Timmreck L.S....Reindollar R.H. (2003)
• A finger sweat chloride test for the detection of a high-risk group of chronic pancreatitis. (PubMed id 15084988)^{1, 3, 6} Naruse S....Hayakawa T. (2004)
• [Frequency of CFTR gene mutations in idiopathic pancreatitis] (PubMed id 12759680)^{1, 3, 6} Maire F....Levy P. (2003)
• Polymorphisms of SPINK1 N34S and CFTR in patients with sporadic and familial pancreatic cancer. (PubMed id 14688470)^{1, 3, 6} Matsubayashi H....Goggins M. (2003)
• Frequency of cystic fibrosis transmembrane conductance regulator gene mutations and 5T allele in patients with allergic bronchopulmonary aspergillosis. (PubMed id 11243954)^{1, 3, 6} Marchand E....Vandenplas O. (2001)
• Analysis of most common CFTR mutations in patients affected by nasal polyps. (PubMed id 16075239)^{1, 3, 6} Kostuch M....Oleszczuk J. (2005)
• Mutation analysis of SPINK1 and CFTR gene in Korean patients with alcoholic chronic pancreatitis. (PubMed id 16187186)^{1, 3, 6} Lee K.H....Yoon Y.B. (2005)
• Mutation analysis of the cystic fibrosis transmembrane conductance regulator (CFTR) gene, the cationic trypsinogen (PRSS1) gene, and the serine protease inhibitor, Kazal type 1 (SPINK1) gene in patients with alcoholic chronic pancreatitis. (PubMed id 12939655)^{1, 3, 6} Perri F....Andriulli A. (2003)
• A novel missense mutation D513G in exon 10 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene identified in a French CBAVD patient. (PubMed id 10651488)^{1, 3, 4} Bienvenu T.... Kaplan J.-C. (1998)
• Is congenital bilateral absence of vas deferens a primary form of cystic fibrosis? Analyses of the CFTR gene in 67 patients. (PubMed id 7529962)^{1, 3, 4} Mercier B.... Ferec C. (1995)
• Bronchiectasis in adult patients: an expression of heterozygosity for CFTR gene mutations? (PubMed id 15151509)^{1, 3, 6} Casals T....Estivill X. (2004)
• CFTR, PRSS1 and SPINK1 mutations in the development of pancreatitis in Brazilian patients. (PubMed id 14526128)^{1, 3, 6} Bernardino A.L....Zatz M. (2003)
• Germline mutations in CFTR and PSTI genes in chronic pancreatitis patients. (PubMed id 12452372)^{1, 3, 6} Gaia E....Carlo A. (2002)
• CFTR and cationic trypsinogen mutations in idiopathic pancreatitis and neonatal hypertrypsinemia. (PubMed id 12120234)^{1, 3, 6} Gomez Lira M....Pignatti P.F. (2001)
• Complete mutational screening of the CFTR gene in 120 patients with pulmonary disease. (PubMed id 9921909)^{1, 3, 4} Bombieri C.... Pignatti P.F. (1998)
• Identification of a novel mutation (S13F) in the CFTR gene in a CF patient of Sardinian origin. (PubMed id 9554753)^{1, 3, 4} Leoni G.B.... Cao A. (1998)
• Identification of two mutations (S50Y and 4173delC) in the CFTR gene from patients with congenital bilateral absence of vas deferens (CBAVD). (PubMed id 9067761)^{1, 3, 4} Zielenski J.... Tsui L.-C. (1997)
• Comparison of the CFTR mutation spectrum in three cohorts of patients of Celtic origin from Brittany (France) and Ireland. (PubMed id 12815607)^{3, 6} Scotet V....Le Marechal C. (2003)
• [The mutation spectrum of the CFTR gene in mucoviscidosis patients from Bashkortostan] (PubMed id 12624947)^{3, 6} Korytina G.F....Khusnutdinova E.K. (2003)
• [Tetranucleotide tandem repeat polymorphism of the CFTR gene intron 6B in populations of the Volga-Ural region] (PubMed id 12068629)^{3, 6} Korytina G.F....Khusnutdinova E.K. (2002)
• [Mutations and polymorphisms in CFTR genes in infertile men with oligospermia or azoospermia] (PubMed id 12073281)^{3, 6} Kusic J....Savic A. (2002)
• [Identification of mutation in the gene cystic fibrosis transmembrane regulator (CFTR) in Chilean patients with cystic fibrosis] (PubMed id 11680956)^{3, 6} Repetto G....Foradori A. (2001)
• Detection of five novel mutations of the cystic fibrosis transmembrane regulator (CFTR) gene in Pakistani patients with cystic fibrosis: Y569D, Q98X, 296+12(T>C), 1161delC and 621+2(T>C). (PubMed id 9482579)^{3, 4} Malone G.... Super M. (1998)
• Analysis of the CFTR gene in Turkish cystic fibrosis patients: identification of three novel mutations (3172delAC, P1013L and M1028I). (PubMed id 9521595)^{3, 4} Onay T....Kirdar B. (1998)
• Novel mutation (A141D) in exon 4 of the CFTR gene identified in an Algerian patient. (PubMed id 9222768)^{3, 4} Gouya L.... Denamur E. (1997)
• Missense mutation R1066C in the second transmembrane domain of CFTR causes a severe cystic fibrosis phenotype: study of 19 heterozygous and 2 homozygous patients. (PubMed id 9375855)^{3, 4} Casals T.... Estivill X. (1997)
• Evidence for phosphorylation of serine 753 in CFTR using a novel metal-ion affinity resin and matrix-assisted laser desorption mass spectrometry. (PubMed id 9385646)^{3, 4} Neville D.C.A....Townsend R.R. (1997)
• Distribution of CFTR mutations in cystic fibrosis patients of Tunisian origin: identification of two novel mutations. (PubMed id 8800923)^{3, 4} Messaoud T.... Ferec C. (1996)
• A novel mutation in exon 12 (Y569C) of the CFTR gene identified in a patient of Croatian origin. (PubMed id 8723693)^{3, 4} Petreska L....Efremov G.D. (1996)
• Mutation characterization of CFTR gene in 206 Northern Irish CF families: thirty mutations, including two novel, account for approximately 94% of CF chromosomes. (PubMed id 8956039)^{3, 4} Hughes D.J....Graham C.A. (1996)
• Structural analysis of CFTR gene in congenital bilateral absence of vas deferens. (PubMed id 7539342)^{3, 4} Jezequel P.... Blayau M. (1995)
• Identification of six novel CFTR mutations in a sample of Italian cystic fibrosis patients. (PubMed id 7541510)^{3, 4} Ferec C.... Mercier B. (1995)
• Complete screening of mutations in the coding sequence of the CFTR gene in a sample of CF patients from Russia: identification of three novel alleles. (PubMed id 7541273)^{3, 4} Verlingue C.... Ferec C. (1995)
• Novel missense mutation in the first transmembrane segment of the CFTR gene (Q98R) identified in a male adult. (PubMed id 7581407)^{3, 4} Romey M.-C....Claustres M. (1995)
• Identification of six mutations (R31L, 441delA, 681delC, 1461ins4, W1089R, E1104X) in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. (PubMed id 7537150)^{3, 4} Zielenski J.... Tsui L.-C. (1995)
• A novel cystic fibrosis mutation, Y109C, in the first transmembrane domain of CFTR. (PubMed id 7524909)^{3, 4} Schaedel C.... Holmberg L. (1994)
• Analysis of the CFTR gene in the Spanish population: SSCP-screening for 60 known mutations and identification of four new mutations (Q30X, A120T, 1812-1 G-->A, and 3667del4). (PubMed id 7517264)^{3, 4} Chillon M.... Estivill X. (1994)
• Identification of eight mutations and three sequence variations in the cystic fibrosis transmembrane conductance regulator (CFTR) gene. (PubMed id 7522211)^{3, 4} Ghaneb N.... Goossens M. (1994)
• A new missense mutation G1249E in exon 20 of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. (PubMed id 7520022)^{3, 4} Greil I.... Rosenkranz W. (1994)
• Detection of more than 50 different CFTR mutations in a large group of German cystic fibrosis patients. (PubMed id 7525450)^{3, 4} Doerk T.... Tuemmler B. (1994)
• Identification of a new missense mutation (P205S) in the first transmembrane domain of the CFTR gene associated with a mild cystic fibrosis phenotype. (PubMed id 7505694)^{3, 4} Chillon M.... Estivill X. (1993)
• Identification of the M1101K mutation in the cystic fibrosis transmembrane conductance regulator (CFTR) gene and complete detection of cystic fibrosis mutations in the Hutterite population. (PubMed id 7680525)^{3, 4} Zielenski J....Morgan K. (1993)
• A new missense mutation (E92K) in the first transmembrane domain of the CFTR gene causes a benign cystic fibrosis phenotype. (PubMed id 7683954)^{3, 4} Nunes V.... Estivill X. (1993)
• Identification of eight novel mutations in a collaborative analysis of a part of the second transmembrane domain of the CFTR gene. (PubMed id 7683628)^{3, 4} Mercier B....Ferec C. (1993)
• Mutations and sequence variations detected in the cystic fibrosis transmembrane conductance regulator (CFTR) gene: a report from the Cystic Fibrosis Genetic Analysis Consortium. (PubMed id 1284534)^{3, 4} Tsui L.-C. (1992)
• Genomic DNA sequence of the cystic fibrosis transmembrane conductance regulator (CFTR) gene. (PubMed id 1710598)^{3, 4} Zielenski J.... Tsui L.-C. (1991)
• Cysteine string protein promotes proteasomal degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) by increasing its interaction with the C terminus of Hsp70-interacting protein and promoting CFTR ubiquitylation. (PubMed id 19098309)^{1, 3} Schmidt B.Z....Frizzell R.A. (2009)
• Derlin-1 promotes the efficient degradation of the cystic fibrosis transmembrane conductance regulator (CFTR) and CFTR folding mutants. (PubMed id 16954204)^{1, 3} Sun F....Frizzell R.A. (2006)
• Chimeric constructs endow the human CFTR Cl- channel with the gating behavior of murine CFTR. (PubMed id 17913891)^{1, 3} Scott-Ward T.S....Boyd A.C. (2007)
• Functional interaction of CFTR and ENaC in sweat glands. (PubMed id 12548396)^{1, 3} Reddy M.M. and Quinton P.M. (2003)
• Variant cystic fibrosis phenotypes in the absence of CFTR mutations. (PubMed id 12167682)^{1, 3} Groman J.D....Cutting G.R. (2002)
• Endosomal SNARE proteins regulate CFTR activity and trafficking in epithelial cells. (PubMed id 18570918)^{1, 3} Bilan F....Thoreau V. (2008)
• The epigenetic signature of CFTR expression is co-ordinated via chromatin acetylation through a complex intronic element. (PubMed id 17848139)^{1, 3} Paul T....Walsh M.J. (2007)
• CFTR Cl- channel function in native human colon correlates with the genotype and phenotype in cystic fibrosis. (PubMed id 15480987)^{1, 3} Hirtz S....Mall M. (2004)
• Association of cystic fibrosis transmembrane conductance regulator (CFTR) mutation/variant/haplotype and tumor necrosis factor (TNF) promoter polymorphism in hyperlipidemic pancreatitis. (PubMed id 17981921)^{1, 3} Chang Y.T....Wong J.M. (2008)
• Small nuclear RNAs U11 and U12 modulate expression of TNR-CFTR mRNA in mammalian kidneys. (PubMed id 18769035)^{1, 3} Souza-Menezes J....Morales M.M. (2008)
• Potentiation of cystic fibrosis transmembrane conductance regulator (CFTR) Cl- currents by the chemical solvent tetrahydrofuran. (PubMed id 18989824)^{1, 3} Hughes L.K....Sheppard D.N. (2008)
• Functional characterization of a novel CFTR mutation P67S identified in a patient with atypical cystic fibrosis. (PubMed id 17495464)^{1, 3} Kraus C....Rauh R. (2007)
• CFTR genotype as a predictor of prognosis in cystic fibrosis. (PubMed id 17099022)^{1, 3} McKone E.F....Aitken M.L. (2006)
• Cell-specific posttranscriptional regulation of CFTR gene expression via influence of MAPK cascades on 3'UTR part of transcripts. (PubMed id 15944206)^{1, 3} Baudouin-Legros M....Edelman A. (2005)
• Increased diffusional mobility of CFTR at the plasma membrane after deletion of its C-terminal PDZ binding motif. (PubMed id 14660592)^{1, 3} Haggie P.M....Verkman A.S. (2004)
• The Hdj-2/Hsc70 chaperone pair facilitates early steps in CFTR biogenesis. (PubMed id 10075921)^{1, 3} Meacham G.C....Cyr D.M. (1999)
• Release of ATP from retinal pigment epithelial cells involves both CFTR and vesicular transport. (PubMed id 15371258)^{1, 3} Reigada D. and Mitchell C.H. (2005)
• Mutation spectrum of the CFTR gene in Taiwanese patients with congenital bilateral absence of the vas deferens. (PubMed id 15905293)^{1, 3} Wu C.C....Wong L.J. (2005)
• Large genomic rearrangements in the CFTR gene contribute to CBAVD. (PubMed id 17448246)^{1, 3} Taulan M....Claustres M. (2007)
• A large deletion in the CFTR gene in CBAVD. (PubMed id 16481891)^{1, 3} Hantash F.M....Strom C.M. (2006)
• Identification of CFTR, PRSS1, and SPINK1 mutations in 381 patients with pancreatitis. (PubMed id 17003641)^{1, 3} Keiles S. and Kammesheidt A. (2006)
• Control of dynamic CFTR selectivity by glutamate and ATP in epithelial cells. (PubMed id 12802335)^{1, 3} Reddy M.M. and Quinton P.M. (2003)
• CFTR gene mutations in patients suffering from acute pancreatitis. (PubMed id 12218938)^{1, 3} Kostuch M....Kulczycki L. (2002)
• Correlation between CFTR gene mutations in Iranian men with congenital absence of the vas deferens and anatomical genital phenotype. (PubMed id 17673436)^{1, 3} Radpour R....Dizaj A.V. (2008)
• [The analysis of CFTR mutations in men with azoospermia, oligozoospermia and asthenozoospermia] (PubMed id 18050608)^{1, 3} Slezak R....Czemarmazowicz H. (2007)
• Mutations of the CFTR gene in Turkish patients with congenital bilateral absence of the vas deferens. (PubMed id 15070876)^{1, 3} Dayangac D....Dork T. (2004)
• CFTR mutations and polymorphisms in male infertility. (PubMed id 15379964)^{1, 3} Cuppens H. and Cassiman J.J. (2004)
• Cystic fibrosis transmembrane conductance regulator (CFTR)-mediated residual chloride secretion does not protect against early chronic Pseudomonas aeruginosa infection in F508del homozygous cystic fibrosis patients. (PubMed id 14605249)^{1, 3} Derichs N....Ballmann M. (2004)
• CFTR gene mutations in Japanese individuals with congenital bilateral absence of the vas deferens. (PubMed id 15463840)^{1, 3} Anzai C....Yoshimura K. (2003)
• Mechanism of G551D-CFTR (cystic fibrosis transmembrane conductance regulator) potentiation by a high affinity ATP analog. (PubMed id 18167357)^{1, 3} Bompadre S.G....Hwang T.C. (2008)
• Outcome of intracytoplasmic sperm injection for a couple in which the man is carrier of CFTR p.[R74W;V201M;D1270N] and p.P841R mutations and his spouse a heterozygous carrier of p.F508del mutation of the cystic fibrosis transmembrane conductance regulator gene. (PubMed id 18703181)^{1, 3} Brugnon F....Creveaux I. (2008)
• Control of basal CFTR gene expression by bicarbonate-sensitive adenylyl cyclase in human pulmonary cells. (PubMed id 18209474)^{1, 3} Baudouin-Legros M....Edelman A. (2008)
• CFTR gene mutations in pancreatitis: Frequency and clinical manifestations in an Austrian patient cohort. (PubMed id 17943404)^{1, 3} Zoller H....Vogel W. (2007)
• Spectrum of mutations and variants/haplotypes of CFTR and genotype-phenotype correlation in idiopathic chronic pancreatitis and controls in Chinese by complete analysis. (PubMed id 17539902)^{1, 3} Chang M.C....Wong J.M. (2007)
• The two ATP binding sites of cystic fibrosis transmembrane conductance regulator (CFTR) play distinct roles in gating kinetics and energetics. (PubMed id 16966475)^{1, 3} Zhou Z....Hwang T.C. (2006)
• Two novel missense and one novel nonsense CFTR mutations in Iranian males with congenital bilateral absence of the vas deferens. (PubMed id 16973827)^{1, 3} Radpour R....Mollamohamadi S. (2006)
• Mutation analysis of CFTR gene in 70 Iranian cystic fibrosis patients. (PubMed id 17242497)^{1, 3} Alibakhshi R. and Zamani M. (2006)
• Cystic fibrosis transmembrane conductance regulator (CFTR) gene mutations in Asians with chronic pulmonary disease: a pilot study. (PubMed id 16678503)^{1, 3} Ngiam N.S....Goh D.Y. (2006)
• Lack of association between UGT1A7, UGT1A9, ARP, SPINK1 and CFTR gene polymorphisms and pancreatic cancer in Italian patients. (PubMed id 17072959)^{1, 3} Piepoli A....Perri F. (2006)
• Na+/H+ exchanger regulatory factor isoform 1 overexpression modulates cystic fibrosis transmembrane conductance regulator (CFTR) expression and activity in human airway 16HBE14o- cells and rescues DeltaF508 CFTR functional expression in cystic fibrosis cells. (PubMed id 16203733)^{1, 3} Guerra L....Casavola V. (2005)
• CFTR genotypes in patients with normal or borderline sweat chloride levels. (PubMed id 12955726)^{1, 3} Feldmann D....Girodon E. (2003)
• Gentamicin-induced correction of CFTR function in patients with cystic fibrosis and CFTR stop mutations. (PubMed id 14534336)^{1, 3} Wilschanski M....Kerem E. (2003)
• Plasma membrane CFTR regulates RANTES expression via its C-terminal PDZ-interacting motif. (PubMed id 12509457)^{1, 3} Estell K....Schwiebert L.M. (2003)
• Mutations of the CFTR gene in pancreatic disease. (PubMed id 14576497)^{1, 3} Pezzilli R....Gullo L. (2003)
• An intrinsic adenylate kinase activity regulates gating of the ABC transporter CFTR. (PubMed id 14697202)^{1, 3} Randak C. and Welsh M.J. (2003)
• Idiopathic pancreatitis related to CFTR: complex inheritance and identification of a modifier gene. (PubMed id 12227654)^{1, 3} Cohn J.A....Jowell P.S. (2002)
• Cystic fibrosis transmembrane regulator (CFTR) DeltaF508 mutation and 5T allele in patients with chronic pancreatitis and exocrine pancreatic cancer. PANKRAS II Study Group. (PubMed id 11115825)^{1, 3} Malats N....Real F.X. (2001)
• Heterogenous spectrum of CFTR gene mutations in Indian patients with congenital absence of vas deferens. (PubMed id 19181743)^{1, 3} Sharma N....Prasad R. (2009)
• Analysis of the CFTR gene in Iranian cystic fibrosis patients: identification of eight novel mutations. (PubMed id 17662673)^{1, 3} Alibakhshi R....Cuppens H. (2008)
• Molecular and functional characterization of CBAVD-causing mutations located in CFTR nucleotide-binding domains. (PubMed id 18769034)^{1, 3} Grangeia A....Sousa M. (2008)

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