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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CFP Gene

protein-coding GIFtS: 60
GCID: GC0XM047484

complement factor properdin

(Previous names: properdin P factor, complement )
(Previous symbol: PFC)

Explore 58 diseases affiliated with
CFP via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Complement Factor Properdin¹ ²		PFD² ⁵
PFC¹ ² ³ ⁵		BFD²
Properdin P Factor, Complement¹ ²		PROPERDIN²
Complement Factor P² ³		Properdin¹

External Ids:	HGNC: 8864¹	Entrez Gene: 5199²	Ensembl: ENSG00000126759⁷	OMIM: 300383⁵	UniProtKB: P27918³

Export aliases for CFP gene to outside databases

Previous GC identifers: GC0XM047368 GC0XM045196

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CFP:

This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate

immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and

C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex

and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in

high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein,

have been identified.(provided by RefSeq, Feb 2009)

UniProtKB/Swiss-Prot: PROP_HUMAN, P27918

Function: A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and

C5-convertase enzyme complexes

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000023.10 NC_018934.1 NT_079573.4

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CFP gene promoter:
CREB deltaCREB NRSF form 1 STAT3 NRSF form 2
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CFP promoter sequence

Search SABiosciences Chromatin IP Primers for CFP

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CFP

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: Xp11.4 Ensembl cytogenetic band: Xp11.23 HGNC cytogenetic band: Xp11.4

CFP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CFP gene location

GeneLoc information about chromosome X GeneLoc Exon Structure

GeneLoc location for GC0XM047484: view genomic region (about GC identifiers)

Start:	47,483,612 bp from pter	End:	47,489,704 bp from pter
Size:	6,093 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: PROP_HUMAN, P27918 (See protein sequence)

Recommended Name: Properdin precursor

Size: 469 amino acids; 51276 Da

Subcellular location: Secreted

Sequence caution: Sequence=CAA15658.1; Type=Erroneous gene model prediction;

2 PDB 3D structures from and Proteopedia for CFP:

1W0R (3D)

1W0S (3D)

Secondary accessions: O15134 O15135 O15136 O75826

Explore the universe of human proteins at neXtProt for CFP: NX_P27918

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P27918

CFP Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (2 alternative transcripts):

NP_001138724.1 NP_002612.1

ENSEMBL proteins:

ENSP00000380189 ENSP00000366204 ENSP00000418258 ENSP00000247153

Reactome Protein details: P27918
Human Recombinant Protein Products:

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	Novus Biologicals CFP Proteins Novus Biologicals CFP Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CFP

Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	TAS	--
GO:0005615	extracellular space	TAS	8530058
GO:0031012	colocalizes with extracellular matrix	IDA	--

CFP for ontologies About GeneDecksing

CFP Antibody Products:

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	Novus Biologicals CFP Antibodies
	Search for Antibodies for CFP at Abcam
	Uscn Antibodies for CFP
	ThermoFisher Antibodies for CFP

Assay Products for CFP:

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	GenScript Custom Assay Services for CFP
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CFP

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CFP for domains About GeneDecksing

1 InterPro domain/family:

IPR000884 Thrombospondin_1_rpt

Graphical View of Domain Structure for InterPro Entry P27918

ProtoNet protein and cluster: P27918

2 Blocks protein families:

IPB000884 Thrombospondin

IPB008085 Thrombospondin type 1 repeat signature

UniProtKB/Swiss-Prot: PROP_HUMAN, P27918

Similarity: Contains 6 TSP type-1 domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: PROP_HUMAN, P27918

Function: A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and

C5-convertase enzyme complexes

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CFP Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CFP
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CFP
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CFP (see all 7) OriGene shRNA RFP: CFP OriGene siRNA: CFP
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Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CFP

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		GenScript: all cDNA clones in your preferred vector (see all 2): CFP (NM_002621)
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CFP

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CFP
		Search LifeMap BioReagents cell lines for CFP

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFP

Animal Models:
Mouse knock-outs for CFP: Cfp^tm1Cmst Cfp^tm1Song
6 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Cfp):

cardiovascular system	homeostasis/metabolism	immune system	mortality/aging	normal
skeleton

CFP for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Activation of C3 and C5

	Activation of C3 and C5	1.00			Alternative complement activation	0.33
	Regulation of Complement cascade	0.38

Immune System

Immune System

1.00

Innate Immune System

0.46

Immune response_Alternative complement pathway

Immune response Alternative complement pathway

1.00

Immune response_Alternative complement pathway

1.00

Cleavage of Alpha-1-Microglobulin

Initial triggering of complement

0.60

Complement cascade

0.47

Pathway sources
See GeneCards unified pathways
Show all pathways

1 EMD Millipore Pathway for CFP

Immune response Alternative complement pathway

1 GeneGo (Thomson Reuters) Pathway for CFP

Immune response Alternative complement pathway

5/7 Reactome Pathways for CFP (see all 7)

	Alternative complement activation
	Regulation of Complement cascade
	Activation of C3 and C5
	Complement cascade
	Immune System

CFP for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CFP

STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

5/6 Interacting proteins for CFP (P27918^{2, 3} ENSP00000247153⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 6)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
C3	P01024³, ENSP00000245907⁴	I2D: score=2 STRING: ENSP00000245907
CFB	P00751³, ENSP00000416561⁴	I2D: score=3 STRING: ENSP00000416561
MTOR	P42345³, ENSP00000354558⁴	I2D: score=1 STRING: ENSP00000354558
ELAVL1	ENSP00000385269⁴	STRING: ENSP00000385269
--	ENSP00000388516⁴	STRING: ENSP00000388516

About this table

Gene Ontology (GO): 5/6 biological process terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006955	immune response	TAS	8530058
GO:0006956	complement activation	TAS	--
GO:0006957	complement activation, alternative pathway	TAS	--
GO:0030449	regulation of complement activation	TAS	--
GO:0042742	defense response to bacterium	TAS	8530058

CFP for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CFP for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CFP
10/14 Novoseek chemical compound relationships for CFP gene (see all 14) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
antistasin	66	3	2303431 (2), 1376110 (1)
anaphylatoxin	46.8	1	1431125 (1)
sulfatide	45.7	5	2303431 (3), 7499866 (2)
procollagen	29.4	1	1426766 (1)
mannan	23.8	2	2311294 (1), 16785571 (1)
dextran sulfate	20	2	2303431 (1)
polysaccharide	4	1	9844044 (1)
magnesium	0	2	2311294 (1), 2247091 (1)
phosphorus	0	1	12175049 (1)
mannose	0	1	17294226 (1)

Search CenterWatch for drugs/clinical trials and news about CFP / PROP

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CFP gene (2 alternative transcripts):

NM_001145252.1 NM_002621.2

Unigene Cluster for CFP:

Complement factor properdin

Hs.53155 [show with all ESTs]

Unigene Representative Sequence: AK122955

7 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000478222 ENST00000396992(uc004dig.4) ENST00000485991(uc004dii.1 uc010nhu.2)

ENST00000377005 ENST00000469388 ENST00000480317 ENST00000247153(uc004dih.3)

miRNA Products:		OriGene 3'-UTR Clone (see all 2): CFP Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CFP
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		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CFP (see all 7) OriGene shRNA RFP: CFP OriGene siRNA: CFP
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CFP

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		GenScript: all cDNA clones in your preferred vector (see all 2): CFP (NM_002621)
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CFP Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CFP
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CFP

Additional cDNA sequence:

AK122955.1 AK310695.1 BC015756.1 M83652.1 X57748.1

5 DOTS entries:

DT.451595 DT.101976133 DT.99969188 DT.86847019 DT.92417183

24/65 AceView cDNA sequences (see all 65):

NM_002621 BU615928 BI768946 BI766222 CD368185 CD615209 BI836039 BC015756

BM920180 BQ067280 CA306934 X57748 T27930 AK122955 BP339567 BG759290

AW337862 BI771282 BM918830 CD615205 CA448790 BI769024 AA293770 CD615202

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CFP expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TCTACACGTG

About this image

CFP expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Liver

Liver Lobule

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CFP Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CFP

SOURCE GeneReport for Unigene cluster: Hs.53155

SABiosciences Custom PCR Arrays for CFP

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CFP Browse OriGene validated miRNA SYBR primer pairs
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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFP

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CFP gene from 2/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	CFP⁶	--	46(a)	1 ↔ 1	2(68353048-68365576)
zebrafish (Danio rerio)	Actinopterygii	si:dkeyp-22b2.3¹	si:dkeyp-22b2.3	49.85(n) 42.82(a)		556399 NM_001160126.1 NP_001153598.1

ENSEMBL Gene Tree for CFP (if available)
TreeFam Gene Tree for CFP (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CFP gene

UNC5B² BAI1² UNC5CL² UNC5C² BAI3² BAI2² UNC5A² UNC5D²

4 SIMAP similar genes for CFP using alignment to 5 protein entries: PROP_HUMAN (see all proteins):

DKFZp762L185 HMCN1 UNC5C UNC5A

CFP for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr X pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs8177085^1,2	C,F	--	47483138(-)	`ACCCTG/ACCGCC`	2	--	ds500¹		3		NS NA	92
rs188064497^1,2		--	47483176(+)	`CATCCA/TCGACT`	2	--	ds500¹		0	--	--	--	--
rs191627866^1,2		--	47483198(+)	`GGAGTC/TGGCCG`	2	--	ds500¹		0	--	--	--	--
rs8177084^1,2	C,F,	--	47483479(-)	`ATTTTC/TCACTG`	2	--	ds500¹		10		NS NA	740
rs183833621^1,2		--	47483494(+)	`TTTTCC/TGCAAC`	2	--	ds500¹		0	--	--	--	--
rs55972826^1,2	C,	--	47483591(+)	`CCTCCA/TTTAAG`	2	--	ds500¹		0	--	--	--	--
rs8177081^1,2	C,F,	--	47483614(-)	`CTCTTC/AGAGTT`	2	--	ut3¹		2		NS	80
rs138490907^1,2	C,F,	--	47483672(+)	`AGAAGT/AGTTAG`	2	--	ut3¹		1		NA	4550
rs141133000^1,2	F	--	47483752(+)	`TTCTGC/ACCTTG`	4	/G	syn¹		1		NA	4550
rs1048118^1,2	C,F,A,H,	--	47483800(-)	`AAGAAT/CGTGAC`	4	/N	syn¹		15		MN NA NS EA WA CSA	5271

HapMap Linkage Disequilibrium report for CFP (47483612 - 47489704 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CFP
1 CNV: 1846
Human Gene Mutation Database (HGMD): CFP

Locus Specific Mutation Databases (LSDB): CFP

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CFP

DNA2.0 Custom Variant and Variant Library Synthesis for CFP

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CFP for disorders           About GeneDecksing

OMIM gene information: 300383
OMIM disorders: 312060
UniProtKB/Swiss-Prot: PROP_HUMAN, P27918

Defects in CFP are the cause of properdin deficiency (PFD) [MIM:312060]. PFD results in higher susceptibility

to bacterial infections; especially to meningococcal infections. Three phenotypes have been reported: complete

deficiency (type I), incomplete deficiency (type II), and dysfunction of properdin (type III)

20/58 diseases for CFP (see all 58): About MalaCards

properdin deficiency meningococcal infection properdin deficiency, x-linked wiskott-aldrich syndrome

acute poststreptococcal glomerulonephritis complement factor i deficiency ehlers-danlos syndrome subacute bacterial endocarditis

combined immunodeficiency afibrinogenemia herpes gestationis membranoproliferative glomerulonephritis

macular degeneration meningitis hyperopia glomerulonephritis

4 diseases from the University of Copenhagen DISEASES database for CFP:

Complement deficiency Nephritis Herpes gestationis Meningitis

10/37 Novoseek disease relationships for CFP gene (see all 37) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
complement deficiency	86.6	2	19388594 (1), 7660072 (1)
meningococcal diseases	80.8	28	8241670 (3), 8469932 (3), 7501623 (2), 17916747 (2) (see all 18)
afibrinogenemia	61.5	2	9476132 (1), 19388157 (1)
glomerulonephritis membranoproliferative	59.5	1	17294226 (1)
hypocomplementemia	56.1	1	2205097 (1)
acute poststreptococcal glomerulonephritis	53.9	1	1996575 (1)
meningitis meningococcal	53.4	1	19419829 (1)
agammaglobulinemia	50.3	1	12522751 (1)
glomerulonephritis	47.7	6	8018502 (1), 19067130 (1), 8604713 (1), 8809142 (1) (see all 6)
meningitis bacterial	45.7	1	17062484 (1)

Human Genome Epidemiology (HuGE) Navigator: CFP (5 documents)

Export disorders for CFP gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CFP gene, integrated from 9 sources (see all 215):
(articles sorted by number of sources associating them with CFP)

Utopia: connect your pdf to the dynamic
world of online information

Expression of properdin in complete and incomplete deficiency: normal in vitro synthesis by monocytes in two cases with properdin deficiency type II due to distinct mutations. (PubMed id 9710744)^{1, 2, 9} Fredrikson G.N....Truedsson L. (1998)
Molecular characterization of properdin deficiency type III: dysfunction produced by a single point mutation in exon 9 of the structural gene causing a tyrosine to aspartic acid interchange. (PubMed id 8871668)^{1, 2, 9} Fredrikson G.N.... Truedsson L. (1996)
Molecular cloning of the cDNA coding for properdin, a positive regulator of the alternative pathway of human complement. (PubMed id 2009915)^{1, 2, 9} Nolan K.F.... Reid K.B.M. (1991)
Molecular characterisation of 10 Dutch properdin type I deficient families: mutation analysis and X-inactivation studies. (PubMed id 10909851)^{1, 2, 9} van den Bogaard R.... Mannens M.M.A.M. (2000)
Properdin, the positive regulator of complement, is highly C- mannosylated. (PubMed id 10878002)^{1, 2, 9} Hartmann S. and Hofsteenge J. (2000)
Sequence-based analysis of properdin deficiency: identification of point mutations in two phenotypic forms of an X-linked immunodeficiency. (PubMed id 8530058)^{1, 2, 9} Westberg J.... Uhlen M. (1995)
Detection of properdin mRNA in human peripheral blood monocytes and spleen. (PubMed id 1431505)^{1, 2, 9} Weiler J.M. and Maves K.K. (1992)
Genetic and physical mapping around the properdin P gene. (PubMed id 1783405)^{1, 3, 9} Coleman M.P....Davies K.E. (1991)
Characterization of the human properdin gene. (PubMed id 1417780)^{1, 2, 9} Nolan K.F.... Reid K.B.M. (1992)
The DNA sequence of the human X chromosome. (PubMed id 15772651)^{1, 2} Ross M.T.... Bentley D.R. (2005)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 5199	HGNC: 8864	AceView: PFC	Ensembl:ENSG00000126759	euGenes: HUgn5199
ECgene: CFP	H-InvDB: CFP

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
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Name	Description
PharmGKB entry for CFP	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CFP
CFPbase	http://bioinf.uta.fi/CFPbase/
SeattleSNPs	http://pga.gs.washington.edu/data/pfc/
Wikipedia	http://en.wikipedia.org/wiki/Properdin

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