Aliases for CFP Gene
External Ids for CFP Gene
Previous HGNC Symbols for CFP Gene
Previous GeneCards Identifiers for CFP Gene
This gene encodes a plasma glycoprotein that positively regulates the alternative complement pathway of the innate immune system. This protein binds to many microbial surfaces and apoptotic cells and stabilizes the C3- and C5-convertase enzyme complexes in a feedback loop that ultimately leads to formation of the membrane attack complex and lysis of the target cell. Mutations in this gene result in two forms of properdin deficiency, which results in high susceptibility to meningococcal infections. Multiple alternatively spliced variants, encoding the same protein, have been identified.[provided by RefSeq, Feb 2009]
GeneCards Summary for CFP Gene
CFP (Complement Factor Properdin) is a Protein Coding gene. Diseases associated with CFP include Properdin Deficiency, X-Linked and Properdin Deficiency. Among its related pathways are Diseases associated with O-glycosylation of proteins and Transport to the Golgi and subsequent modification. An important paralog of this gene is ADGRB2.
UniProtKB/Swiss-Prot for CFP Gene
A positive regulator of the alternate pathway of complement. It binds to and stabilizes the C3- and C5-convertase enzyme complexes.