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CFLAR Gene

protein-coding   GIFtS: 68
GCID: GC02P201980

CASP8 And FADD-Like Apoptosis Regulator


(Previous symbol: CASP8AP1)
Microbiology & Infectious Diseases Congress
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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
CASP8 And FADD-Like Apoptosis Regulator1 2     FADD-Like Antiapoptotic Molecule 12 3
CASP8AP11 2 3     MACH-Related Inducer Of Toxicity2 3
CASH2 3 5     FLAME12 5
Caspase Homolog2 3     FLIP2 5
Caspase-Eight-Related Protein2 3     FLAME2
Caspase-Like Apoptosis Regulatory Protein2 3     c-FLIPL2
Cellular FLICE-Like Inhibitory Protein2 3     c-FLIPR2
Inhibitor Of FLICE2 3     c-FLIPS2
CLARP2 3     Caspase-Related Inducer Of Apoptosis2
Casper2 3     FADD-Like Anti-Apoptotic Molecule2
FLAME-12 3     Usurpin Beta2
I-FLICE2 3     Usurpin3
MRIT2 3     CASPER5
c-FLIP2 3     

External Ids:    HGNC: 18761   Entrez Gene: 88372   Ensembl: ENSG000000034027   OMIM: 6035995   UniProtKB: O155193   

Export aliases for CFLAR gene to outside databases

Previous GC identifers: GC02P200197 GC02P200705 GC02P201944 GC02P202183 GC02P201806 GC02P201689 GC02P193832


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CFLAR Gene:
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However,
the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8.
Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for
several more variants exists. (provided by RefSeq, Feb 2011)

GeneCards Summary for CFLAR Gene:
CFLAR (CASP8 and FADD-like apoptosis regulator) is a protein-coding gene. Diseases associated with CFLAR include nodular lymphocyte predominant hodgkin lymphoma, and granulosa cell tumor of the ovary. GO annotations related to this gene include enzyme activator activity and protease binding.

UniProtKB/Swiss-Prot: CFLAR_HUMAN, O15519
Function: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death
pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is
likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and
processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce
apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity

Gene Wiki entry for CFLAR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000002.12  NT_005403.18  NC_018913.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CFLAR gene promoter:
         TBP   STAT1   p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CFLAR promoter sequence
   Search Chromatin IP Primers for CFLAR

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CFLAR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33-q34   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33-q34

CFLAR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CFLAR gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P201980:  view genomic region     (about GC identifiers)

Start:
201,980,827 bp from pter      End:
202,041,410 bp from pter
Size:
60,584 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CFLAR_HUMAN, O15519 (See protein sequence)
Recommended Name: CASP8 and FADD-like apoptosis regulator precursor  
Size: 480 amino acids; 55344 Da
Subunit: TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by
TNFRSF6, FADD and caspase-8. A proteolytic fragment (p43) stays associated with the DISC. Also interacts with
caspase-10, caspase-3, TRAF1, TRAF2 and Bcl-X(L) (in vitro). Interacts with HBV protein X
2 PDB 3D structures from and Proteopedia for CFLAR:
3H11 (3D)        3H13 (3D)    
Secondary accessions: B4DJE0 B7Z9F9 O14673 O14674 O14675 O15137 O15138 O15356 O15510 O43618
O43619 O43620 O60458 O60459 Q53TS6 Q54AF1 Q96TE4 Q9UEW1
Alternative splicing: 15 isoforms:  O15519-1   O15519-2   O15519-3   O15519-4   O15519-5   O15519-6   O15519-7   O15519-8   
O15519-9   O15519-10   O15519-11   O15519-12   O15519-13   O15519-14   O15519-15   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CFLAR: NX_O15519

Explore proteomics data for CFLAR at MOPED

Post-translational modifications: 

  • Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43
    and p121
  • Ubiquitination2 at Lys192
  • Modification sites at PhosphoSitePlus

  • See CFLAR Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (8 alternative transcripts): 
    NP_001120655.1  NP_001120656.1  NP_001189444.1  NP_001189445.1  NP_001189446.1  NP_001189447.1  NP_001189448.1  NP_003870.4  

    ENSEMBL proteins: 
     ENSP00000312455   ENSP00000413270   ENSP00000339335   ENSP00000345807   ENSP00000342809  
     ENSP00000378580   ENSP00000411897   ENSP00000391029   ENSP00000399420   ENSP00000398551  
     ENSP00000409570   ENSP00000412882   ENSP00000406775   ENSP00000411535   ENSP00000469608  
     ENSP00000471749   ENSP00000469917   ENSP00000471805   ENSP00000347757   ENSP00000339326  
    Reactome Protein details: O15519

    CFLAR Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CFLAR (FLIP)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CFLAR
    OriGene Protein Over-expression Lysate for CFLAR
    OriGene MassSpec for CFLAR
    OriGene Custom Protein Services for CFLAR
    GenScript Custom Purified and Recombinant Proteins Services for CFLAR
    Novus Biologicals CFLAR Proteins
    Novus Biologicals CFLAR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates
    ProSpec Recombinant Protein for CFLAR
    Cloud-Clone Corp. Proteins for CFLAR

    CFLAR Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CFLAR
    R&D Systems Antibodies for CFLAR (FLIP)
    Cell Signaling Technology (CST) Antibodies for CFLAR 
    OriGene Antibodies for CFLAR
    OriGene Custom Antibody Services for CFLAR
    Novus Biologicals CFLAR Antibodies
    Abcam antibodies for CFLAR (O15519, O15519-10)
    Cloud-Clone Corp. Antibodies for CFLAR
    ThermoFisher Antibody for CFLAR
    LSBio Antibodies in human, mouse, rat for CFLAR

    CFLAR Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CFLAR
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CFLAR
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CFLAR
    Cloud-Clone Corp. CLIAs for CFLAR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    ENDOLIG: Endogenous ligands

    5 InterPro protein domains:
     IPR001309 Pept_C14_ICE_p20
     IPR011029 DEATH-like_dom
     IPR015917 Pept_C14A_p45_core
     IPR011600 Pept_C14_caspase
     IPR001875 DED

    Graphical View of Domain Structure for InterPro Entry O15519

    ProtoNet protein and cluster: O15519

    UniProtKB/Swiss-Prot: CFLAR_HUMAN, O15519
    Domain: The caspase domain lacks the active sites residues involved in catalysis
    Similarity: Belongs to the peptidase C14A family
    Similarity: Contains 2 DED (death effector) domains


    CFLAR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CFLAR_HUMAN, O15519
    Function: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death
    pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is
    likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and
    processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce
    apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity
    Induction: Repressed by IL2/interleukin-2 after TCR stimulation, during progression to the S phase of the cell
    cycle

         Genatlas biochemistry entry for CFLAR:
    caspase eight related,predominantly expressed in skeletal muscle,pancreas,heart,activated by Fas
    ligand,interacting with FADD and promoting apoptosis

         Gene Ontology (GO): Selected molecular function terms (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI9208847
    GO:0004197NOT cysteine-type endopeptidase activity IKR--
    GO:0005515protein binding IPI11741985
    GO:0008047enzyme activator activity IDA9208847
    GO:0008234cysteine-type peptidase activity ----
         
    CFLAR for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CFLAR:
     Decreased nuclei size in G2M  Synthetic lethal with gemcitab 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cflar):
     cardiovascular system  cellular  embryogenesis  growth/size/body  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  muscle 

    CFLAR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CFLAR: Cflartm1.2Pope Cflartm1Mak

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CFLAR
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CFLAR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CFLAR
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CFLAR

    miRNA
    Products:
        
    miRTarBase miRNAs that target CFLAR:
    hsa-mir-346 (MIRT004228), hsa-mir-7-5p (MIRT025744), hsa-mir-26a-5p (MIRT050158)

    Block miRNA regulation of human, mouse, rat CFLAR using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CFLAR:
    hsa-miR-495 hsa-miR-7-2* hsa-miR-370 hsa-miR-7-1* hsa-miR-802 hsa-miR-24 hsa-miR-3145-3p hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidCFLAR 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CFLAR
    Predesigned siRNA for gene silencing in human, mouse, rat CFLAR

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CFLAR

    Clone
    Products:
         
    OriGene clones in human, mouse for CFLAR (see all 20)
    OriGene ORF clones in mouse, rat for CFLAR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): CFLAR (NM_003879)
    Sino Biological Human cDNA Clone for CFLAR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CFLAR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CFLAR

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CFLAR
    Browse ESI BIO Cell Lines and PureStem Progenitors for CFLAR 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFLAR


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    plasma membrane5
    cytosol3
    nucleus3
    mitochondrion2

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA18073330
    GO:0005829cytosol TAS--
    GO:0031264death-inducing signaling complex IDA--
    GO:0031265CD95 death-inducing signaling complex IEA--
    GO:0097342ripoptosome IDA--

    CFLAR for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CFLAR About   (see all 17)  
    See pathways by source

    SuperPathContained pathways About
    1TWEAK Pathway
    Apoptosis and survival TNFR1 signaling pathway0.52
    TRAIL Pathway0.40
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    Fas Signaling0.35
    Apoptosis through Death Receptors0.42
    2Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    FAS pathway and Stress induction of HSP regulation0.44
    3Death Receptor Signalling
    Death Receptor Signalling0.71
    Regulation by c-FLIP0.00
    Dimerization of procaspase-80.71
    Caspase-8 activation0.00
    TRAIL signaling0.00
    Extrinsic Pathway for Apoptosis0.00
    4Apoptotic Pathways in Synovial Fibroblasts
    Cellular Apoptosis Pathway0.85
    Apoptotic Pathways in Synovial Fibroblasts0.84
    5Apoptosis (WikiPathways)
    Apoptosis0.38
    Apoptosis Modulation and Signaling0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CFLAR (see all 8)
        Molecular Mechanisms of Cancer
    TRAIL Pathway
    Apoptotic Pathways in Synovial Fibroblasts
    Fas Signaling
    all-trans-Retinoic Acid Mediated Apoptosis

    1 Cell Signaling Technology (CST) Pathway for CFLAR
        Apoptosis and Autophagy

    2 GeneGo (Thomson Reuters) Pathways for CFLAR
        Apoptosis and survival FAS signaling cascades
    Apoptosis and survival TNFR1 signaling pathway

    Selected BioSystems Pathways for CFLAR (see all 8)
        Apoptosis
    Apoptosis Modulation and Signaling
    FAS pathway and Stress induction of HSP regulation
    TNF-alpha/NF-kB Signaling Pathway
    TRAIL signaling pathway


    3 Reactome Pathways for CFLAR
        TRAIL signaling
    Regulation by c-FLIP
    Dimerization of procaspase-8


    4 Kegg Pathways  (Kegg details for CFLAR):
        NF-kappa B signaling pathway
    Apoptosis
    TNF signaling pathway
    Chagas disease (American trypanosomiasis)


    CFLAR for pathways           About GeneDecksing

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CFLAR (see all 13): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CFLAR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CFLAR (O155191, 2, 3 ENSP000003124554) via UniProtKB, MINT, STRING, and/or I2D (see all 75)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP2K7O147331, 2, 3, ENSP000003810664EBI-4567563,EBI-492605 MINT-3391541 MINT-3391468 I2D: score=1 STRING: ENSP00000381066
    CASP8Q147901, 2, 3, ENSP000003512734EBI-4567563,EBI-78060 MINT-4055334 I2D: score=5 STRING: ENSP00000351273
    CASP10Q928511, 3, ENSP000002861864EBI-514941,EBI-495095 I2D: score=4 STRING: ENSP00000286186
    DAXXQ9UER73, ENSP000003968764I2D: score=2 STRING: ENSP00000396876
    ENSG00000206206Q9UER73I2D: score=2 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 20):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis ----
    GO:0006915apoptotic process TAS--
    GO:0007519skeletal muscle tissue development ISS--
    GO:0014732skeletal muscle atrophy ISS--
    GO:0014842regulation of satellite cell proliferation ISS--

    CFLAR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CFLAR

    Selected Novoseek inferred chemical compound relationships for CFLAR gene (see all 68)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cycloheximide 63.4 47 11309649 (3), 11359904 (2), 18289527 (2), 10919673 (2) (see all 23)
    suberoylanilide hydroxamic acid 62.4 10 18765530 (3), 19483104 (2), 18065490 (1), 17690692 (1)
    mg 132 61.5 12 16537561 (2), 11359904 (1), 16082182 (1), 16037944 (1) (see all 10)
    bortezomib 60.2 7 17659339 (2), 17897295 (1), 19100720 (1), 16024631 (1) (see all 5)
    ly294002 56.3 9 11440972 (2), 19426671 (1), 11145953 (1), 14605879 (1) (see all 8)
    flavopiridol 51.9 20 16820931 (2), 15385934 (1), 18065490 (1), 16951203 (1) (see all 5)
    gw9662 50.6 2 17172826 (1)
    3,3'-diindolylmethane 50.6 5 16373712 (2), 17071604 (2)
    doxorubicin 49.1 18 15638938 (5), 17106251 (4), 17513603 (2), 12496481 (2) (see all 8)
    bisindolylmaleimide 46.4 11 10828032 (3), 11877293 (1), 12163389 (1), 15928597 (1)



    CFLAR for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
    About This Section

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    REFSEQ mRNAs for CFLAR gene (8 alternative transcripts): 
    NM_001127183.2  NM_001127184.2  NM_001202515.1  NM_001202516.1  NM_001202517.1  NM_001202518.1  NM_001202519.1  NM_003879.5  

    Unigene Cluster for CFLAR:

    CASP8 and FADD-like apoptosis regulator
    Hs.390736  [show with all ESTs]
    Unigene Representative Sequence: NM_001202519
    Selected Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000309955(uc002uxb.4 uc010zhk.2 uc010zhl.2 uc002uxc.4 uc010fsx.3 uc010fsy.3 uc002uxf.3 uc002uxg.3)
    ENST00000443227 ENST00000341222(uc002uwz.3) ENST00000341582 ENST00000342795(uc021vuw.1)
    ENST00000395148(uc002uwy.3) ENST00000441224 ENST00000433445 ENST00000423241(uc010fsw.2 uc002uxd.4)
    ENST00000490965 ENST00000439154 ENST00000425030 ENST00000417748 ENST00000440180(uc002uxe.2)
    ENST00000461820 ENST00000457277(uc010zhm.2 uc010fsz.3) ENST00000461422
    ENST00000494258
    Congresses - knowledge worth sharing:
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

    miRNA
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    Block miRNA regulation of human, mouse, rat CFLAR using miScript Target Protectors
    8 qRT-PCR Assays for microRNAs that regulate CFLAR:
    hsa-miR-495 hsa-miR-7-2* hsa-miR-370 hsa-miR-7-1* hsa-miR-802 hsa-miR-24 hsa-miR-3145-3p hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidCFLAR 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CFLAR
    Predesigned siRNA for gene silencing in human, mouse, rat CFLAR
    Clone
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    OriGene clones in human, mouse for CFLAR (see all 20)
    OriGene ORF clones in mouse, rat for CFLAR
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 8): CFLAR (NM_003879)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CFLAR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CFLAR
    Primer
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    OriGene qPCR primer pairs and template standards for CFLAR
    OriGene qSTAR qPCR primer pairs in human, mouse for CFLAR
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CFLAR
      QuantiTect SYBR Green Assays in human, mouse, rat CFLAR
      QuantiFast Probe-based Assays in human, mouse, rat CFLAR

    Additional mRNA sequence: 

    AB209600.1 AF005774.1 AF005775.1 AF009616.1 AF009617.1 AF009618.1 AF009619.1 AF010127.1 
    AF015450.1 AF015451.1 AF015452.1 AF041458.1 AF041459.1 AF041460.1 AF041461.1 AF041462.1 
    AK124664.1 AK125394.1 AK289913.1 AK296036.1 AK297387.1 AK304585.1 AK308767.1 AK315208.1 
    AK315924.1 AL365413.1 BC001602.1 BC148237.1 BC148289.1 BT006751.1 U85059.1 U97074.1 
    U97075.1 Y14039.1 Y14040.1 

    Selected DOTS entries (see all 51):

    DT.456302  DT.92325571  DT.100827245  DT.436456  DT.95292598  DT.91755054  DT.95361165  DT.65288187 
    DT.120956660  DT.91678225  DT.91833890  DT.432406  DT.95354587  DT.100827248  DT.92065440  DT.120956626 
    DT.92067137  DT.87002404  DT.91755061  DT.100827253  DT.100827246  DT.100827247  DT.91755056  DT.100827251 

    Selected AceView cDNA sequences (see all 324):

    CA394435 BQ082459 AI290035 BX095997 BM969271 T48754 CA949933 AA099326 
    AU117908 BX956432 CA309455 AI889520 AU122196 AV660305 BC000801 BU684028 
    AI057390 BC001602 T08780 AI095092 F01470 AF015451 BM838613 BQ709107 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CFLAR (see all 22)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^
    SP1:                    -     -     -     -     -     -     -                             -     -     -                                               -     -   
    SP2:                                      -     -     -     -                             -     -     -                                               -     -   
    SP3:                                                                                      -     -     -                                               -     -   
    SP4:                                                                                      -     -     -                                               -     -   
    SP5:                                                                                      -     -     -                                               -     -   

    ExUns: 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c
    SP1:  -           -     -     -     -                       -                 -                     
    SP2:  -           -     -     -     -                       -                 -                     
    SP3:  -           -     -     -     -                       -                                       
    SP4:  -           -     -     -     -                                                               
    SP5:  -           -     -     -     -                       -     -     -     -                     


    ECgene alternative splicing isoforms for CFLAR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CFLAR expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAACTGCCTC
    CFLAR Expression
    About this image


    CFLAR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Brain (Nervous System)    fully expand to see all 5 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 3 entries
             Pre-Granulosa Cells Primordial Follicle
             Oviduct
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
     
     Testis (Reproductive System)
             Leydig Cells Testis Interstitium
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
    CFLAR Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CFLAR Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.390736

    UniProtKB/Swiss-Prot: CFLAR_HUMAN, O15519
    Tissue specificity: Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and
    peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis
    and skeletal muscle

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CFLAR (see all 13): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for CFLAR
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    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CFLAR
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    QuantiFast Probe-based Assays in human, mouse, rat CFLAR
    In Situ
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFLAR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for CFLAR gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cflar1 , 5 CASP8 and FADD-like apoptosis regulator1, 5 75.72(n)1
    67.79(a)1
      1 (29.16 cM)5
    126331  NM_207653.31  NP_997536.11 
     587115085 
    chicken
    (Gallus gallus)
    Aves CFLAR1 CASP8 and FADD-like apoptosis regulator 57.94(n)
    51.06(a)
      424080  NM_001202462.2  NP_001189391.1 
    lizard
    (Anolis carolinensis)
    Reptilia CFLAR6
    CASP8 and FADD-like apoptosis regulator
    44(a)
    1 ↔ 1
    GL343478.1(392496-421272)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cflar1 CASP8 and FADD-like apoptosis regulator 49.96(n)
    42.02(a)
      779578  XM_004917781.1  XP_004917838.1 
    zebrafish
    (Danio rerio)
    Actinopterygii AF448261.12   -- 72.07(n)   373114  AF448261.1 


    ENSEMBL Gene Tree for CFLAR (if available)
    TreeFam Gene Tree for CFLAR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CFLAR gene
    Selected SIMAP similar genes for CFLAR using alignment to 11 protein entries:     CFLAR_HUMAN (see all proteins) (see all similar genes):
    ZNF738    CHID1    ZNF74    ZNF83    AURA2    UTY
    APOD    CTSS    RNF217    ZNF564    ZNF737    LINC00596
    PLA2G6    ZNF547    SHANK2    NF2    TMEM14B    TSEN2

    CFLAR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CFLAR (see all 1095)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1998526641,2
    C--193833999(+) AAGATC/TTNNNN 6 -- int1 us2k10--------
    rs134069931,2
    C--193877884(+) tttttC/Tttttt 7 -- int1 trp34Minor allele frequency- T:0.12NA WA 8
    rs1916041991,2
    C--201368526(+) GCGCCC/TGCCAT 5 -- us2k10--------
    rs729310111,2
    C,F--201368743(+) GGTGGC/TATGCT 5 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1837046241,2
    --201368874(+) CTCAAA/GAACAA 5 -- us2k10--------
    rs1413500731,2
    --201368961(+) TTAACA/TCCAGA 5 -- us2k10--------
    rs1469710411,2
    --201368983(+) GTTGTA/GTGGGA 5 -- us2k10--------
    rs1895947381,2
    --201369019(+) CATAAC/TTTGGC 5 -- us2k10--------
    rs1925642041,2
    --201369045(+) CATGAC/TTATAA 5 -- us2k10--------
    rs1854481261,2
    --201369080(+) AAACAA/C/GAATAT 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for CFLAR (201980827 - 202041410 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CFLAR: --
    Human Gene Mutation Database (HGMD): CFLAR
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CFLAR
    DNA2.0 Custom Variant and Variant Library Synthesis for CFLAR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603599    OMIM disorders: --

    Selected diseases for CFLAR (see all 113):    
    About MalaCards
    nodular lymphocyte predominant hodgkin lymphoma    granulosa cell tumor of the ovary    cadasil    cervical intraepithelial neoplasia
    salivary gland cancer    thrombotic thrombocytopenic purpura    hodgkin's lymphoma    cholangiocarcinoma
    large granular lymphocyte leukemia    molluscum contagiosum    actinic keratosis    colon adenocarcinoma
    endometrial carcinoma    malignant glioma    langerhans-cell histiocytosis    kaposi's sarcoma
    cervical adenocarcinoma    burkitt's lymphoma    thyroid cancer    bladder carcinoma


    CFLAR for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    Selected Novoseek inferred disease relationships for CFLAR gene (see all 81)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 77 55 9380701 (1), 11359904 (1), 15059915 (1), 17011514 (1) (see all 39)
    tumors 68.1 174 19223508 (6), 11145953 (5), 18309685 (5), 19846923 (3) (see all 93)
    cancer 59.3 88 18288942 (4), 19773432 (3), 19932761 (2), 15833082 (2) (see all 46)
    colon cancer 46.9 28 15832422 (6), 16373718 (3), 18314627 (3), 16052516 (3) (see all 9)
    malignant glioma 46.4 6 19398149 (2), 12496285 (1), 19158480 (1), 19409438 (1)
    ovarian cancer 44.9 24 19802016 (3), 19959214 (3), 15258564 (3), 20227749 (2) (see all 10)
    cadasil 44.3 1 19419383 (1)
    prostate cancer 39.8 46 19095249 (7), 16537561 (4), 18790747 (4), 17332355 (3) (see all 14)
    leukemia b-cell 38.9 3 15851579 (1), 16140959 (1), 16105982 (1)
    hodgkin disease 36.1 25 15354734 (7), 16441226 (2), 17659339 (2), 18042067 (2) (see all 9)

    Genetic Association Database (GAD): CFLAR
    Human Genome Epidemiology (HuGE) Navigator: CFLAR (18 documents)

    Export disorders for CFLAR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CFLAR gene, integrated from 10 sources (see all 831):
    (articles sorted by number of sources associating them with CFLAR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Casper is a FADD- and caspase-related inducer of apoptosis. (PubMed id 9208847)1, 2, 3, 9 Shu H.-B.... Goeddel D.V. (Immunity 1997)
    2. Inhibition of death receptor signals by cellular FLIP. (PubMed id 9217161)1, 2, 3, 9 Irmler M.... Tschopp J. (Nature 1997)
    3. A single nucleotide polymorphism determines protein isoform production of the human c-FLIP protein. (PubMed id 19439735)1, 4, 9 Ueffing N....Schwerk C. (Blood 2009)
    4. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis. (PubMed id 9380701)1, 2, 9 Inohara N.... Nunez G. (Proc. Natl. Acad. Sci. U.S.A. 1997)
    5. The role of c-FLIP in modulation of CD95-induced apoptosis. (PubMed id 9880531)1, 2, 9 Scaffidi C.... Peter M.E. (J. Biol. Chem. 1999)
    6. Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis. (PubMed id 10227994)1, 2, 9 Algeciras-Schimnich A.... Paya C.V. (J. Immunol. 1999)
    7. Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex. (PubMed id 10200473)1, 2, 9 Rasper D.M....Nicholson D.W. (Cell Death Differ. 1998)
    8. Common single nucleotide polymorphisms in immunoregulatory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (Am. J. Hematol. 2010)
    9. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility &quot;hot-spot&quot;. (PubMed id 20628624)1, 4 Johnatty S.E.... . (PLoS Genet. 2010)
    10. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (Carcinogenesis 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8837 HGNC: 1876 AceView: CFLAR Ensembl:ENSG00000003402 euGenes: HUgn8837
    ECgene: CFLAR Kegg: 8837 H-InvDB: CFLAR

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CFLAR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CFLAR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CFLAR gene:
    Search GeneIP for patents involving CFLAR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, and ESI BIO, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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