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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CFLAR Gene

protein-coding   GIFtS: 68
GCID: GC02P201980

CASP8 And FADD-Like Apoptosis Regulator


(Previous symbol: CASP8AP1)
Microbiology & Infectious Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
CASP8 And FADD-Like Apoptosis Regulator1 2     FADD-Like Antiapoptotic Molecule 12 3
CASP8AP11 2 3     MACH-Related Inducer Of Toxicity2 3
CASH2 3 5     FLAME12 5
Caspase Homolog2 3     FLIP2 5
Caspase-Eight-Related Protein2 3     FLAME2
Caspase-Like Apoptosis Regulatory Protein2 3     c-FLIPL2
Cellular FLICE-Like Inhibitory Protein2 3     c-FLIPR2
Inhibitor Of FLICE2 3     c-FLIPS2
CLARP2 3     Caspase-Related Inducer Of Apoptosis2
Casper2 3     FADD-Like Anti-Apoptotic Molecule2
FLAME-12 3     Usurpin Beta2
I-FLICE2 3     Usurpin3
MRIT2 3     CASPER5
c-FLIP2 3     

External Ids:    HGNC: 18761   Entrez Gene: 88372   Ensembl: ENSG000000034027   OMIM: 6035995   UniProtKB: O155193   

Export aliases for CFLAR gene to outside databases

Previous GC identifers: GC02P200197 GC02P200705 GC02P201944 GC02P202183 GC02P201806 GC02P201689 GC02P193832


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CFLAR Gene:
The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However,
the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8.
Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for
several more variants exists. (provided by RefSeq, Feb 2011)

GeneCards Summary for CFLAR Gene: 
CFLAR (CASP8 and FADD-like apoptosis regulator) is a protein-coding gene. Diseases associated with CFLAR include cadasil, and nodular lymphocyte predominant hodgkin lymphoma, and among its related super-pathways are TNFR1 Pathway and Apoptosis and survival FAS signaling cascades. GO annotations related to this gene include enzyme activator activity and protease binding.

UniProtKB/Swiss-Prot: CFLAR_HUMAN, O15519
Function: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death
pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is
likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and
processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce
apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity

Gene Wiki entry for CFLAR Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000002.11  NT_005403.17  NC_018913.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CFLAR gene promoter:
         TBP   STAT1   p53   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CFLAR promoter sequence
   Search SABiosciences Chromatin IP Primers for CFLAR

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CFLAR


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33-q34   Ensembl cytogenetic band:  2q33.1   HGNC cytogenetic band: 2q33-q34

CFLAR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CFLAR gene location

GeneLoc information about chromosome 2         GeneLoc Exon Structure

GeneLoc location for GC02P201980:  view genomic region     (about GC identifiers)

Start:
201,980,827 bp from pter      End:
202,037,411 bp from pter
Size:
56,585 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CFLAR_HUMAN, O15519 (See protein sequence)
Recommended Name: CASP8 and FADD-like apoptosis regulator precursor  
Size: 480 amino acids; 55344 Da
Subunit: TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by
TNFRSF6, FADD and caspase-8. A proteolytic fragment (p43) stays associated with the DISC. Also interacts with
caspase-10, caspase-3, TRAF1, TRAF2 and Bcl-X(L) (in vitro). Interacts with HBV protein X
2 PDB 3D structures from and Proteopedia for CFLAR:
3H11 (3D)        3H13 (3D)    
Secondary accessions: B4DJE0 B7Z9F9 O14673 O14674 O14675 O15137 O15138 O15356 O15510 O43618
O43619 O43620 O60458 O60459 Q53TS6 Q54AF1 Q96TE4 Q9UEW1
Alternative splicing: 15 isoforms:  O15519-1   O15519-2   O15519-3   O15519-4   O15519-5   O15519-6   O15519-7   O15519-8   
O15519-9   O15519-10   O15519-11   O15519-12   O15519-13   O15519-14   O15519-15   (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CFLAR: NX_O15519

Explore proteomics data for CFLAR at MOPED 

Post-translational modifications:

  • UniProtKB: Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43
    and p12
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O15519

  • CFLAR Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CFLAR Protein Expression
    REFSEQ proteins (8 alternative transcripts): 
    NP_001120655.1  NP_001120656.1  NP_001189444.1  NP_001189445.1  NP_001189446.1  NP_001189447.1  NP_001189448.1  NP_003870.4  

    ENSEMBL proteins: 
     ENSP00000312455   ENSP00000413270   ENSP00000339335   ENSP00000345807   ENSP00000342809  
     ENSP00000378580   ENSP00000411897   ENSP00000391029   ENSP00000399420   ENSP00000398551  
     ENSP00000409570   ENSP00000412882   ENSP00000406775   ENSP00000411535   ENSP00000469608  
     ENSP00000471749   ENSP00000469917   ENSP00000471805   ENSP00000347757   ENSP00000339326  
    Reactome Protein details: O15519
    Human Recombinant Protein Products for CFLAR: 
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    R&D Systems Recombinant & Natural Proteins for CFLAR (FLIP)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CFLAR
    OriGene Protein Over-expression Lysate for CFLAR
    OriGene MassSpec for CFLAR 
    OriGene Custom Protein Services for CFLAR
    GenScript Custom Purified and Recombinant Proteins Services for CFLAR
    Novus Biologicals CFLAR Proteins
    Novus Biologicals CFLAR Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    ProSpec Recombinant Protein for CFLAR
    Cloud-Clone Corp. Proteins for CFLAR 

    Gene Ontology (GO): 3 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005737cytoplasm IDA18073330
    GO:0005829cytosol TAS--
    GO:0031264death-inducing signaling complex IDA--

    CFLAR for ontologies           About GeneDecksing



    CFLAR Antibody Products: 
    EMD Millipore Mono- and Polyclonal Antibodies for the study of CFLAR
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    Novus Biologicals CFLAR Antibodies
    Abcam antibodies for CFLAR
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    LSBio Antibodies in human, mouse, rat for CFLAR 

    Assay Products for CFLAR: 
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    Cloud-Clone Corp. ELISAs for CFLAR 
    Cloud-Clone Corp. CLIAs for CFLAR


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    5/6 InterPro protein domains (see all 6):
     IPR001309 Pept_C14_ICE_p20
     IPR011029 DEATH-like_dom
     IPR015917 Pept_C14_p45_core
     IPR011600 Pept_C14_cat
     IPR002398 Pept_C14_p45

    Graphical View of Domain Structure for InterPro Entry O15519

    ProtoNet protein and cluster: O15519

    UniProtKB/Swiss-Prot: CFLAR_HUMAN, O15519
    Domain: The caspase domain lacks the active sites residues involved in catalysis
    Similarity: Belongs to the peptidase C14A family
    Similarity: Contains 2 DED (death effector) domains


    CFLAR for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CFLAR_HUMAN, O15519
    Function: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death
    pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is
    likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and
    processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce
    apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity
    Induction: Repressed by IL2/interleukin-2 after TCR stimulation, during progression to the S phase of the cell
    cycle

         Genatlas biochemistry entry for CFLAR:
    caspase eight related,predominantly expressed in skeletal muscle,pancreas,heart,activated by Fas
    ligand,interacting with FADD and promoting apoptosis

         Gene Ontology (GO): 5 molecular function terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0002020protease binding IPI9208847
    GO:0004197cysteine-type endopeptidase activity IEA--
    GO:0005515protein binding IPI11741985
    GO:0008047enzyme activator activity IDA9208847
    GO:0008234cysteine-type peptidase activity ----
         
    CFLAR for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CFLAR:
     Decreased nuclei size in G2M  Synthetic lethal with gemcitab 

         9 MGI mutant phenotypes (inferred from 4 alleles(MGI details for Cflar):
     cardiovascular system  cellular  embryogenesis  growth/size  hematopoietic system 
     homeostasis/metabolism  immune system  mortality/aging  muscle 

    CFLAR for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-outs for CFLAR: Cflartm1.2Pope Cflartm1Mak

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CFLAR 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CFLAR

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CFLAR 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CFLAR 

    miRNA
    Products:
        
    miRTarBase miRNAs that target CFLAR:
    hsa-mir-346 (MIRT004228)

    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CFLAR
    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CFLAR:
    hsa-miR-495 hsa-miR-7-2* hsa-miR-370 hsa-miR-7-1* hsa-miR-802 hsa-miR-24 hsa-miR-3145-3p hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidCFLAR 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CFLAR

    Gene Editing
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    Sirion Biotech Customized adenovirus for overexpression of CFLAR

    Clone
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    Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
    OriGene clones in human, mouse for CFLAR (see all 19)
    OriGene ORF clones in mouse, rat for CFLAR
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    GenScript: all cDNA clones in your preferred vector (see all 8): CFLAR (NM_003879)
    Sino Biological Human cDNA Clone for CFLAR
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CFLAR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CFLAR
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                         Customized lentivirus expression plasmids for stable overexpression of CFLAR 

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFLAR


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CFLAR About   (see all 17)                                                                                              See pathways by source

    SuperPathContained pathways About
    1TWEAK Pathway
    Apoptosis and survival TNFR1 signaling pathway0.52
    TRAIL Pathway0.40
    HIV-1 Nef- Negative effector of Fas and TNF-alpha0.46
    Fas Signaling0.35
    Apoptosis through Death Receptors0.42
    2Apoptosis and survival Caspase cascade
    Apoptosis and survival FAS signaling cascades0.44
    FAS pathway and Stress induction of HSP regulation0.44
    3Regulation by c-FLIP
    Extrinsic Pathway for Apoptosis0.93
    Regulation by c-FLIP0.90
    4Apoptotic Pathways in Synovial Fibroblasts
    Cellular Apoptosis Pathway0.85
    Apoptotic Pathways in Synovial Fibroblasts0.84
    5Apoptosis Modulation and Signaling
    Apoptosis0.38
    Apoptosis Modulation and Signaling0.38

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for CFLAR
        Apoptosis and survival TNFR1 signaling pathway
    Apoptosis and survival FAS signaling cascades

    5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CFLAR (see all 8)
        Molecular Mechanisms of Cancer
    TRAIL Pathway
    Apoptotic Pathways in Synovial Fibroblasts
    Fas Signaling
    all-trans-Retinoic Acid Mediated Apoptosis

    1 Cell Signaling Technology (CST) Pathway for CFLAR
        Apoptosis and Autophagy

    2 GeneGo (Thomson Reuters) Pathways for CFLAR
        Apoptosis and survival FAS signaling cascades
    Apoptosis and survival TNFR1 signaling pathway

    5/8 BioSystems Pathways for CFLAR (see all 8)
        Apoptosis
    Apoptosis Modulation and Signaling
    FAS pathway and Stress induction of HSP regulation
    TNF-alpha/NF-kB Signaling Pathway
    HIV-1 Nef- Negative effector of Fas and TNF-alpha


    3        Reactome Pathways for CFLAR
        Extrinsic Pathway for Apoptosis
    Regulation by c-FLIP
    Apoptosis


    4         Kegg Pathways  (Kegg details for CFLAR):
        NF-kappa B signaling pathway
    Apoptosis
    TNF signaling pathway
    Chagas disease (American trypanosomiasis)


    CFLAR for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CFLAR

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/70 Interacting proteins for CFLAR (O155191, 2, 3 ENSP000003124554) via UniProtKB, MINT, STRING, and/or I2D (see all 70)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    MAP2K7O147332, 3, ENSP000003810664MINT-3391541 MINT-3391468 I2D: score=1 STRING: ENSP00000381066
    CASP8Q147902, 3, ENSP000003512734MINT-4055334 I2D: score=5 STRING: ENSP00000351273
    CASP10Q928511, 3, ENSP000002861864EBI-514941,EBI-495095 I2D: score=4 STRING: ENSP00000286186
    DAXXQ9UER73, ENSP000003968764I2D: score=2 STRING: ENSP00000396876
    ENSG00000206206Q9UER73I2D: score=2 
    About this table

    Gene Ontology (GO): 5/18 biological process terms (GO ID links to tree view) (see all 18):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006508proteolysis IEA--
    GO:0006915apoptotic process TAS--
    GO:0007519skeletal muscle tissue development ISS--
    GO:0014732skeletal muscle atrophy ISS--
    GO:0014842regulation of satellite cell proliferation ISS--

    CFLAR for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CFLAR for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CFLAR

    10/68 Novoseek inferred chemical compound relationships for CFLAR gene (see all 68)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cycloheximide 63.4 47 11309649 (3), 11359904 (2), 18289527 (2), 10919673 (2) (see all 23)
    suberoylanilide hydroxamic acid 62.4 10 18765530 (3), 19483104 (2), 18065490 (1), 17690692 (1)
    mg 132 61.5 12 16537561 (2), 11359904 (1), 16082182 (1), 16037944 (1) (see all 10)
    bortezomib 60.2 7 17659339 (2), 17897295 (1), 19100720 (1), 16024631 (1) (see all 5)
    ly294002 56.3 9 11440972 (2), 19426671 (1), 11145953 (1), 14605879 (1) (see all 8)
    flavopiridol 51.9 20 16820931 (2), 15385934 (1), 18065490 (1), 16951203 (1) (see all 5)
    gw9662 50.6 2 17172826 (1)
    3,3'-diindolylmethane 50.6 5 16373712 (2), 17071604 (2)
    doxorubicin 49.1 18 15638938 (5), 17106251 (4), 17513603 (2), 12496481 (2) (see all 8)
    bisindolylmaleimide 46.4 11 10828032 (3), 11877293 (1), 12163389 (1), 15928597 (1)

    Search CenterWatch for drugs/clinical trials and news about CFLAR

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CFLAR gene (8 alternative transcripts): 
    NM_001127183.2  NM_001127184.2  NM_001202515.1  NM_001202516.1  NM_001202517.1  NM_001202518.1  NM_001202519.1  NM_003879.5  

    Unigene Cluster for CFLAR:

    CASP8 and FADD-like apoptosis regulator
    Hs.390736  [show with all ESTs]
    Unigene Representative Sequence: NM_001202519
    18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):
    ENST00000309955(uc002uxb.4 uc010zhk.2 uc010zhl.2 uc002uxc.4 uc010fsx.3 uc010fsy.3 uc002uxf.3 uc002uxg.3)
    ENST00000443227 ENST00000341222(uc002uwz.3) ENST00000341582 ENST00000342795(uc021vuw.1)
    ENST00000395148(uc002uwy.3) ENST00000441224 ENST00000433445 ENST00000423241(uc010fsw.2 uc002uxd.4)
    ENST00000490965 ENST00000439154 ENST00000425030 ENST00000417748 ENST00000440180(uc002uxe.2)
    ENST00000461820 ENST00000457277(uc010zhm.2 uc010fsz.3) ENST00000461422
    ENST00000494258
    Congresses - knowledge worth sharing:  
    European Congress of Clinical Microbiology and Infectious Diseases (ECCMID) 10 - 13 May 2014

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    8 QIAGEN miScript miRNA Assays for microRNAs that regulate CFLAR:
    hsa-miR-495 hsa-miR-7-2* hsa-miR-370 hsa-miR-7-1* hsa-miR-802 hsa-miR-24 hsa-miR-3145-3p hsa-miR-192*
    SwitchGear 3'UTR luciferase reporter plasmidCFLAR 3' UTR sequence
    Inhib. RNA
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    Clone
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    OriGene ORF clones in mouse, rat for CFLAR
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    GenScript: all cDNA clones in your preferred vector (see all 8): CFLAR (NM_003879)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CFLAR
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CFLAR
    Sirion Biotech Customized lentivirus for stable overexpression of CFLAR 
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      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CFLAR

    Additional mRNA sequence: 

    AB209600.1 AF005774.1 AF005775.1 AF009616.1 AF009617.1 AF009618.1 AF009619.1 AF010127.1 
    AF015450.1 AF015451.1 AF015452.1 AF041458.1 AF041459.1 AF041460.1 AF041461.1 AF041462.1 
    AK124664.1 AK125394.1 AK289913.1 AK296036.1 AK297387.1 AK304585.1 AK308767.1 AK315208.1 
    AK315924.1 AL365413.1 BC001602.1 BC148237.1 BC148289.1 BT006751.1 U85059.1 U97074.1 
    U97075.1 Y14039.1 Y14040.1 

    24/51 DOTS entries (see all 51):

    DT.456302  DT.92325571  DT.100827245  DT.436456  DT.95292598  DT.91755054  DT.95361165  DT.65288187 
    DT.120956660  DT.91678225  DT.91833890  DT.432406  DT.95354587  DT.100827248  DT.92065440  DT.120956626 
    DT.92067137  DT.87002404  DT.91755061  DT.100827253  DT.100827246  DT.100827247  DT.91755056  DT.100827251 

    24/324 AceView cDNA sequences (see all 324):

    AK125394 BQ708319 BU151434 AL694971 BQ720714 BU684028 AW069527 AI095092 
    CF541103 CR619610 CD742741 AI769483 BU685922 BF895815 BP341411 BM827180 
    AW275852 CA306141 BI871546 BM844234 BM912239 CB148618 CD367074 CR594605 

    GeneLoc Exon Structure

    5/22 Alternative Splicing Database (ASD) splice patterns (SP) for CFLAR (see all 22)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^
    SP1:                    -     -     -     -     -     -     -                             -     -     -                                               -     -   
    SP2:                                      -     -     -     -                             -     -     -                                               -     -   
    SP3:                                                                                      -     -     -                                               -     -   
    SP4:                                                                                      -     -     -                                               -     -   
    SP5:                                                                                      -     -     -                                               -     -   

    ExUns: 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c
    SP1:  -           -     -     -     -                       -                 -                     
    SP2:  -           -     -     -     -                       -                 -                     
    SP3:  -           -     -     -     -                       -                                       
    SP4:  -           -     -     -     -                                                               
    SP5:  -           -     -     -     -                       -     -     -     -                     


    ECgene alternative splicing isoforms for CFLAR

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CFLAR expression in normal human tissues (normalized intensities)      CFLAR embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAACTGCCTC
    CFLAR Expression
    About this image


    CFLAR expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/10 selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 2 entries
             Choroid Plexus
             brain/hindbrain/4th ventricle   
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Pre-Granulosa Cells Primordial Follicle
     
     Primitive Streak (Early Embryonic Tissues)
             Mesendoderm-like cells ( Generation of mesendoderm and definitive endoderm cells...
     
     Gut Tube (Gastrointestinal Tract)
             Definitive endoderm-like cells ( A scalable, suspension protocol for derivation of...
     
     Inner Cell Mass (Early Embryonic Tissues)
             Line H9 (WA09)

    See CFLAR Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CFLAR

    SOURCE GeneReport for Unigene cluster: Hs.390736

    UniProtKB/Swiss-Prot: CFLAR_HUMAN, O15519
    Tissue specificity: Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and
    peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis
    and skeletal muscle

        SABiosciences Expression via Pathway-Focused PCR Arrays including CFLAR (see all 13): 
              G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat
              Cancer PathwayFinder in human mouse rat
              Inflammasomes in human mouse rat
              Liver Cancer in human mouse rat
              Apoptosis in human mouse rat

    Primer
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFLAR

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CFLAR gene from 4/10 species (see all 10)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cflar1 , 5 CASP8 and FADD-like apoptosis regulator1, 5 75.72(n)1
    68(a)1
      1 (29.16 cM)5
    126331  NM_207653.31  NP_997536.11 
     587115085 
    chicken
    (Gallus gallus)
    Aves CFLAR1 CASP8 and FADD-like apoptosis regulator 58.05(n)
    51.28(a)
      424080  NM_001202462.1  NP_001189391.1 
    lizard
    (Anolis carolinensis)
    Reptilia CFLAR6
    CASP8 and FADD-like apoptosis regulator
    44(a)
    1 ↔ 1
    GL343478.1(392496-421272)
    zebrafish
    (Danio rerio)
    Actinopterygii AF448261.12   -- 72.07(n)   373114  AF448261.1 


    ENSEMBL Gene Tree for CFLAR (if available)
    TreeFam Gene Tree for CFLAR (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CFLAR gene
    18/38 SIMAP similar genes for CFLAR using alignment to 11 protein entries:     CFLAR_HUMAN (see all proteins) (see all similar genes):
    ZNF738    CHID1    ZNF74    ZNF83    AURA2    UTY
    APOD    RNF217    ZNF564    ZNF737    LINC00596    PLA2G6
    ZNF547    SHANK2    NF2    TMEM14B    TSEN2    SEPT2

    CFLAR for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/1095 SNPs in CFLAR are shown (see all 1095)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 2 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1998526641,2
    C--193833999(+) AAGATC/TTNNNN 6 -- int1 us2k10--------
    rs134069931,2
    C--193877884(+) tttttC/Tttttt 7 -- int1 trp34Minor allele frequency- T:0.12NA WA 8
    rs1916041991,2
    C--201368526(+) GCGCCC/TGCCAT 5 -- us2k10--------
    rs729310111,2
    C,F--201368743(+) GGTGGC/TATGCT 5 -- us2k11Minor allele frequency- T:0.03WA 118
    rs1837046241,2
    --201368874(+) CTCAAA/GAACAA 5 -- us2k10--------
    rs1413500731,2
    --201368961(+) TTAACA/TCCAGA 5 -- us2k10--------
    rs1469710411,2
    --201368983(+) GTTGTA/GTGGGA 5 -- us2k10--------
    rs1895947381,2
    --201369019(+) CATAAC/TTTGGC 5 -- us2k10--------
    rs1925642041,2
    --201369045(+) CATGAC/TTATAA 5 -- us2k10--------
    rs1854481261,2
    --201369080(+) AAACAA/C/GAATAT 5 -- us2k10--------

    HapMap Linkage Disequilibrium report for CFLAR (201980827 - 202037411 bp)

    Structural Variations
          Database of Genomic Variants (DGV) variations for CFLAR: --

    Human Gene Mutation Database (HGMD): CFLAR
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CFLAR
    DNA2.0 Custom Variant and Variant Library Synthesis for CFLAR

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 603599    OMIM disorders: --

    20/112 diseases for CFLAR (see all 112):    About MalaCards
    cadasil    nodular lymphocyte predominant hodgkin lymphoma    salivary gland cancer    cholangiocarcinoma
    hiv-1, resistance to    cervical intraepithelial neoplasia    granulosa cell tumor of the ovary    thrombotic thrombocytopenic purpura
    large granular lymphocyte leukemia    molluscum contagiosum    actinic keratosis    colon adenocarcinoma
    langerhans-cell histiocytosis    kaposi's sarcoma    endometrial carcinoma    malignant glioma
    cervical adenocarcinoma    histiocytosis    bladder carcinoma    thyroid cancer


    CFLAR for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/81 Novoseek inferred disease relationships for CFLAR gene (see all 81)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    necrosis 77 55 9380701 (1), 11359904 (1), 15059915 (1), 17011514 (1) (see all 39)
    tumors 68.1 174 19223508 (6), 11145953 (5), 18309685 (5), 19846923 (3) (see all 93)
    cancer 59.3 88 18288942 (4), 19773432 (3), 19932761 (2), 15833082 (2) (see all 46)
    colon cancer 46.9 28 15832422 (6), 16373718 (3), 18314627 (3), 16052516 (3) (see all 9)
    malignant glioma 46.4 6 19398149 (2), 12496285 (1), 19158480 (1), 19409438 (1)
    ovarian cancer 44.9 24 19802016 (3), 19959214 (3), 15258564 (3), 20227749 (2) (see all 10)
    cadasil 44.3 1 19419383 (1)
    prostate cancer 39.8 46 19095249 (7), 16537561 (4), 18790747 (4), 17332355 (3) (see all 14)
    leukemia b-cell 38.9 3 15851579 (1), 16140959 (1), 16105982 (1)
    hodgkin disease 36.1 25 15354734 (7), 16441226 (2), 17659339 (2), 18042067 (2) (see all 9)

    Genetic Association Database (GAD): CFLAR
    Human Genome Epidemiology (HuGE) Navigator: CFLAR (18 documents)

    Export disorders for CFLAR gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CFLAR gene, integrated from 9 sources (see all 825):
    (articles sorted by number of sources associating them with CFLAR)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Casper is a FADD- and caspase-related inducer of apoptosis. (PubMed id 9208847)1, 2, 3, 9 Shu H.-B.... Goeddel D.V. (1997)
    2. Inhibition of death receptor signals by cellular FLIP. (PubMed id 9217161)1, 2, 3, 9 Irmler M.... Tschopp J. (1997)
    3. A single nucleotide polymorphism determines protein i soform production of the human c-FLIP protein. (PubMed id 19439735)1, 4, 9 Ueffing N....Schwerk C. (2009)
    4. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis. (PubMed id 9380701)1, 2, 9 Inohara N.... Nunez G. (1997)
    5. The role of c-FLIP in modulation of CD95-induced apoptosis. (PubMed id 9880531)1, 2, 9 Scaffidi C.... Peter M.E. (1999)
    6. Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis. (PubMed id 10227994)1, 2, 9 Algeciras-Schimnich A.... Paya C.V. (1999)
    7. Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex. (PubMed id 10200473)1, 2, 9 Rasper D.M....Nicholson D.W. (1998)
    8. Common single nucleotide polymorphisms in immunoregul atory genes and multiple myeloma risk among women in Connecticut. (PubMed id 20568250)1, 4 Lee K.M....Lan Q. (2010)
    9. Evaluation of candidate stromal epithelial cross-talk genes identifies association between risk of serous ovarian cancer and TERT, a cancer susceptibility 'hot-spot'. (PubMed id 20628624)1, 4 Johnatty S.E.... . (2010)
    10. A Large-scale genetic association study of esophageal adenocarcinoma risk. (PubMed id 20453000)1, 4 Liu C.Y....Christiani D.C. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8837 HGNC: 1876 AceView: CFLAR Ensembl:ENSG00000003402 euGenes: HUgn8837
    ECgene: CFLAR Kegg: 8837 H-InvDB: CFLAR

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CFLAR Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CFLAR Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CFLAR gene:
    Search GeneIP for patents involving CFLAR

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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    About This Section

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