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CFLAR Gene

protein-coding GIFtS: 63

GC02P201689

CASP8 and FADD-like apoptosis regulator
Symbol approved by the HUGO Gene Nomenclature Committee (HGNC) database
(Previous symbol: CASP8AP1)

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc , and/or ⁷Ensembl, ⁸miRBase)
About This Section

Aliases
CASH ^¹, ², ³, ⁵
CASP8AP1 ^², ³
CASPER ^⁵
CLARP ^¹, ², ³
Casper ^¹, ², ³
FLAME ^¹, ²
FLAME-1 ^², ³
FLAME1 ^², ⁵
FLIP ^¹, ², ⁵
I-FLICE ^¹, ², ³
MRIT ^¹, ², ³
Usurpin ^³
c-FLIP ^², ³
c-FLIPL ^²
c-FLIPR ^²
c-FLIPS ^²

Descriptions
CASP8 and FADD-like apoptosis regulator ^²
Caspase homolog ^³
Caspase-eight-related protein ^³
Caspase-like apoptosis regulatory protein ^³
Cellular FLICE-like inhibitory protein ^³
FADD-like anti-apoptotic molecule ^²
FADD-like antiapoptotic molecule 1 ^³
Inhibitor of FLICE ^², ³
MACH-related inducer of toxicity ^³
caspase-related inducer of apoptosis ^²
usurpin beta ^²

External Ids
HGNC: 1876¹
Entrez Gene: 8837²
UniProtKB: O15519³
Ensembl: ENSG00000003402⁷

Search outside databases for aliases for CFLAR gene

Previous GC identifers: GC02P200197 GC02P200705 GC02P201944 GC02P202183 GC02P201806

(According to Entrez Gene, Wikipedia's Gene Wiki,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

UniProtKB/Swiss-Prot: CFLAR_HUMAN, O15519

Function: Apoptosis regulator protein which may function as a crucial link between cell survival

and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A

proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC)

thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and

shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered

apoptosis. Lacks enzymatic (caspase) activity

Gene Wiki entry for CFLAR

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to UCSC and Ensembl, Transcription factor binding sites according to SABiosciences)
About This Section

Genomic View:

UCSC Golden Path with GeneCards custom track

Transcription factor binding sites upstream to the CFLAR gene

Entrez Gene cytogenetic band: 2q33-q34 Ensembl cytogenetic band: 2q33.1 HGNC cytogenetic band: 2q33-q34

CFLAR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)

GeneLoc gene densities for chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P201689: (about GC identifiers)

Start:	201,689,135 bp from pter
End:	201,737,260 bp from pter
Size:	48,126 bases
Orientation:	plus strand

RefSeq DNA sequence:

NC_000002.10 NT_005403.16

(According to ¹UniProtKB, and/or Ensembl, Phosphorylation sites according to ²Phosphosite, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Enzo Life Sciences, Abnova, OriGene and/or, Abcam,
Biochemical Assays by Invitrogen, Millipore, R&D Systems, Cell Signaling Technology, and/or Enzo Life Sciences, Ontologies according to Gene Ontology Consortium 01 Apr 2009 and Entrez Gene, Antibodies by Invitrogen, Millipore, Sigma-Aldrich, R&D Systems, Cell Signaling Technology, Abcam, Abnova, and/or Novus Biologicals)
About This Section

UniProtKB/Swiss-Prot: CFLAR_HUMAN, O15519 (See protein sequence)

Recommended Name: CASP8 and FADD-like apoptosis regulator precursor

Size: 480 amino acids; 55344 Da

Subunit: TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC)

formed by TNFRSF6, FADD and caspase-8. A proteolytic fragment (p43) stays associated with the

DISC. Also interacts with caspase-10, caspase-3, TRAF1, TRAF2 and Bcl-X(L) (in vitro). Interacts

with HBV protein X

PDB structure from and Proteopedia :

3H11 (3D)

3H13 (3D)

Secondary accessions: O14673 O14674 O14675 O15137 O15138 O15356 O15510 O43618 O43619 O43620 O60458

O60459 Q54AF1 Q96TE4 Q9UEW1

Alternative splicing: 14 isoforms: O15519-1 O15519-2 O15519-3 O15519-4 O15519-5 O15519-6 O15519-7 O15519-8

O15519-9 O15519-10 O15519-11 O15519-12 O15519-13 O15519-14

Post-translational modifications:

Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and

generates subunit p43 and p12¹

View phosphorylation sites using PhosphoSite²

REFSEQ proteins (3 alternative transcripts):

NP_001120655.1 NP_001120656.1 NP_003870.4

ENSEMBL proteins:

ENSP00000363789 ENSP00000312455 ENSP00000345807 ENSP00000347757 ENSP00000339326 ENSP00000342809

ENSP00000339335 ENSP00000339391

Human Recombinant Proteins

	Browse Drug Discovery Central at Invitrogen for human recombinant proteins
	Browse Purified and Recombinant Proteins at Millipore
	Browse Human Recombinant Proteins at Sigma-Aldrich
	R&D Systems Recombinant & Natural Proteins for CFLAR (FLIP)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	Recombinant Proteins from Abcam (FLIP delta + gamma, FLIP)
	Human Recombinant Proteins from Abnova (CFLAR)

OriGene Purified Recombinant Human Protein: CFLAR

Antibodies for CFLAR:

	Invitrogen Antibodies for CFLAR
	Millipore Mono- and Polyclonal Antibodies for the study of CFLAR
	Sigma-Aldrich Antibody Arrays and Antibodies for CFLAR
	R&D Systems Antibodies for CFLAR (FLIP)
	Antibodies from Abcam (FLIP delta + gamma, FLIP), each with their Abpromise^SM
	Monoclonal and Polyclonal Antibodies from Abnova (CFLAR)
	Novus Biologicals Antibodies for CFLAR

Assays for CFLAR:

	Browse Invitrogen for biochemical assays
	Browse Kits and Assays available from Millipore
	Browse R&D Systems for biochemical assays
	Browse biochemical assays available from Enzo Life Sciences

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

Graphical View of Domain Structure for InterPro Entry O15519

ProtoNet protein and cluster: O15519

UniProtKB/Swiss-Prot: CFLAR_HUMAN, O15519

Domain: The caspase domain lacks the active sites residues involved in catalysis

Similarity: Belongs to the peptidase C14A family

Similarity: Contains 2 DED (death effector) domains

(According to MGI Jun 06 2009, UniProtKB, IUBMB,and/or Genatlas,
shRNA from OriGene, Sigma-Aldrich, RNAi from Sigma-Aldrich,
RNAi Products, Clones, and Q-PCR Products from Invitrogen, Millipore, OriGene, and/or Abnova, siRNAs from Applied Biosystems, SYBR primers from OriGene, Cell-based Assays from Millipore, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CFLAR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CFLAR)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_003879

Applied Biosystems Silencer® siRNAs for CFLAR

Sigma-Aldrich siRNA and siRNA Panels for CFLAR

Sigma-Aldrich shRNA Panels and shRNA for CFLAR

Explore Sigma-Aldrich super-pooled esiRNAs

Clones:		Invitrogen Clones for CFLAR
		Browse Clones for the Expression of Recombinant Proteins Available from Millipore

OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001127183
Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001127183
untagged cDNA clones in CMV expression vector (see all 3): NM_001127183

Primers:

Browse Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers

OriGene genome-wide validated SYBR primer pairs: NM_003879

UniProtKB/Swiss-Prot: CFLAR_HUMAN, O15519

Function: Apoptosis regulator protein which may function as a crucial link between cell survival

and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A

proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC)

thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and

shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered

apoptosis. Lacks enzymatic (caspase) activity

Induction: Repressed by IL-2 after TCR stimulation, during progression to the S-phase of the cell

cycle

Genatlas biochemistry entry for CFLAR:

caspase eight related,predominantly expressed in skeletal muscle,pancreas,heart,activated by Fas

ligand,interacting with FADD and promoting apoptosis

9 MGI mutant phenotypes (inferred from 2 alleles) (MGI details for Cflar):

	cellular	embryogenesis	growth/size	hematopoietic system
homeostasis/metabolism	immune system	lethality-prenatal/perinatal	muscle

2 Gene Ontology (GO) molecular function terms (links to tree view):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004197	cysteine-type endopeptidase activity	IEA	--
GO:0005515	protein binding	IPI	11741985

About this table

(Pathways according to Invitrogen (maps by GeneGo), Millipore, Cell Signaling Technology, Sigma-Aldrich, KEGG and/or UniProtKB,
Sets of similar genes according to GeneDecks, Proteins Network according to SABiosciences, Interactions according to ¹UniProtKB, ²MINT, and/or ³STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2009 via Entrez Gene.)
About This Section

2 Sigma-Aldrich "Your Favorite Gene" Pathways for CFLAR (Your Favorite Gene powered by Ingenuity)

Death Receptor Signaling
Molecular Mechanisms of Cancer

GeneDecks CFLAR for the pathways selected above

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Gene Network Central^TM Interacting Genes and Proteins Network for CFLAR

5/75 Interacting proteins for CFLAR (O15519¹ ENSP00000312455³) via UniProtKB, MINT, and/or STRING (see all 75 )

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
DOK2	O60496¹	EBI-514941, EBI-1046024
SF3B3	Q15393¹	EBI-514941, EBI-346977
CASP10	ENSP00000286186³	STRING (score=.999)
CASP8	ENSP00000351273³	STRING (score=.999)
FADD	ENSP00000301838³	STRING (score=.999)

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5/6 Gene Ontology (GO) biological process terms (links to tree view) (see all 6 ):

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0006916	anti-apoptosis	TAS	9217161
GO:0008624	induction of apoptosis by extracellular signals	TAS	9208847
GO:0042981	regulation of apoptosis	IEA	--
GO:0043123	positive regulation of I-kappaB kinase/NF-kappaB cascade	IEP	12761501

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, Sigma-Aldrich, Tocris Bioscience, and/or Novoseek and Drugs according to Enzo Life Sciences and/or PharmGKB)
About This Section

Browse drugs & compounds from Enzo Life Sciences

Browse Small Molecules at Sigma-Aldrich

Browse Tocris compounds for CFLAR
10/22 Novoseek chemical compound relationships for CFLAR gene (see all 22 )

Compound	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
gw9662	54.81	2	17172826 (1)
bisindolylmaleimide	47.98	11	10828032 (3), 11877293 (1), 12163389 (1), 15928597 (1)
noxa	47.20	2	16273296 (1), 18723481 (1)
gamma-tocotrienol	44.15	1	17114179 (1)
phosphatidylinositol	39.87	12	11145953 (4), 11440972 (2), 14583609 (1), 17071604 (1) (see all 7)
pd 98,059	32.04	4	11169411 (1), 19426671 (1), 11145953 (1), 11440972 (1)
wortmannin	31.83	6	11440972 (2), 12861043 (1), 12874095 (1)
dutp	31.64	5	12957613 (1), 19059832 (1)
ceramide	27.92	8	12635660 (5), 11821946 (1), 16170023 (1), 10726692 (1)
threonine	15.28	5	14551207 (1), 16434995 (1), 17047155 (1), 11486001 (1) (see all 5)

About this table

(GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 219 Homo sapiens; Jun 2 2009) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView,
non coding RNAs according to RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from Invitrogen, Millipore, and/or Abnova,
siRNAs from Applied Biosystems, Sigma-Aldrich,
shRNA from Sigma-Aldrich, OriGene,
Tagged/untagged cDNA clones from OriGene,
Expression Assays from Applied Biosystems)
About This Section

Inhib. RNA:		Invitrogen RNAi Products for gene knock-down (CFLAR)
		Browse for Gene Knock-down Tools from Millipore
		Abnova Chimera RNAi Products for Gene knock-down (CFLAR)

OriGene 29mer shRNA kit in GFP-retroviral vectors (see all 3): NM_003879

Sigma-Aldrich siRNA and siRNA Panels for CFLAR

Sigma-Aldrich shRNA Panels and shRNA for CFLAR

Explore Sigma-Aldrich super-pooled esiRNAs

Applied Biosystems Silencer® siRNAs:

NM_001127183 NM_001127184 NM_003879

REFSEQ mRNAs for CFLAR gene (3 alternative transcripts):

NM_001127183.1 NM_001127184.1 NM_003879.4

Applied Biosystems TaqMan ® Gene Expression Assays:

NM_001127183 NM_001127184 NM_003879

               OriGene GFP tagged cDNA clones in CMV expression vector (see all 3): NM_001127183
                                 Myc/DDK tagged cDNA clones in CMV expression vector (see all 3): NM_001127183
                                 untagged cDNA clones in CMV expression vector (see all 3): NM_001127183

Additional cDNA sequence:

AB209600.1 AF005774.1 AF005775.1 AF009616.1 AF009617.1 AF009618.1 AF009619.1 AF010127.1

AF015450.1 AF015451.1 AF015452.1 AF041458.1 AF041459.1 AF041460.1 AF041461.1 AF041462.1

AK289913.1 AK296036.1 AK297387.1 AK304585.1 AK308767.1 AK315208.1 AK315924.1 AL365413.1

BC000801.1 BC001602.1 BC148237.1 BC148289.1 BT006751.1 CR594605.1 CR615942.1 CR619610.1

U85059.1 U97074.1 U97075.1 Y14039.1 Y14040.1

24/51 DOTS entries (see all 51 ):

DT.456302 DT.91755054 DT.92325571 DT.100827245 DT.120956629 DT.95292598 DT.120956660 DT.91833890

DT.95361165 DT.65288187 DT.432406 DT.75100566 DT.92065440 DT.100827256 DT.120956569 DT.100827246

DT.120956626 DT.92067137 DT.120956612 DT.91755061 DT.95354587 DT.100827253 DT.117887 DT.91841519

24/324 AceView cDNA sequences (see all 324 ):

AL694971 CB158243 U97074 BQ722885 BU687121 CA309455 BM969271 BQ019611

T30922 T48754 BQ082459 BM838613 AI191802 AV660305 CA394435 CB162701

BM980445 BI871546 BU608142 AA099861 BU151434 CB158528 AF010127 T08780

highest scoring ESTs for CFLAR:

AA002262 AA115793 AA151642 AA358043 AA379905 AA467756 AA467995 AA565691 AA922168 AF005775

Unigene Cluster for CFLAR:

CASP8 and FADD-like apoptosis regulator

Hs.390736 [show with all ESTs]

Unigene Representative Sequence: AB209600

GeneLoc Exon Structure

5/22 Alternative Splicing Database (ASD) splice patterns (SP) for CFLAR (see all 22 )

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f	^	7	^	8a	·	8b	·	8c	·	8d	·	8e	^	9a	·	9b	·	9c	·	9d	^	10	^	11	^
SP1:							-		-		-		-		-		-		-										-		-		-																-		-
SP2:													-		-		-		-										-		-		-																-		-
SP3:																													-		-		-																-		-
SP4:																													-		-		-																-		-
SP5:																													-		-		-																-		-

ExUns:	12a	·	12b	·	12c	^	13a	·	13b	·	13c	^	14	^	15	^	16	^	17	^	18a	·	18b	^	19	^	20a	·	20b	·	20c
SP1:	-				-		-		-		-								-						-
SP2:	-				-		-		-		-								-						-
SP3:	-				-		-		-		-								-
SP4:	-				-		-		-		-
SP5:	-				-		-		-		-								-		-		-		-

About this scheme

ECgene alternative splicing isoforms for CFLAR

8 Ensembl transcripts including schematic representations:

ENST00000325671 ENST00000309955 ENST00000341582 ENST00000355558 ENST00000340870 ENST00000342795

ENST00000341222 ENST00000343375

(Experimental results according to ¹GeneNote and GNF BioGPS,
probe sets-to-genes annotations according to ²GeneAnnot , ³GeneTide , Sets of similar genes according to GeneDecks, Electronic Northern calculations according to data from UniGene (Build 219 Homo sapiens), SAGE tags according to CGAP, plus additional links to SOURCE, and/or GNF BioGPS, and/or EXPOLDB, and/or UniProtKB,
Expression Assays from Applied Biosystems )
About This Section

CFLAR expression in normal and diseased human tissues

Applied Biosystems TaqMan ® Gene Expression Assays for CFLAR

¹ / ² / ³

25 probe-sets matching CFLAR gene

Affymetrix probe-set	Array	# genes	Sensitivity	Specificity	Correlation	Length	Gb_Accession	Consensus	Uniqueness	Score	Rank
Affymetrix probe-set	Array	GeneAnnot data			GeneNote data		GeneTide data
1867_at²^{, 3}	U95-A	1	1.00	1.00	0.85	1.11	AF005775	0.80	1.00	0.91	1
32746_at²^{, 3}	U95-A	1	1.00	1.00	0.92	0.62	AF015451	0.80	0.80	0.80	1
1868_g_at²^{, 3}	U95-A	1	1.00	1.00	0.95	0.84	AF005775	0.80	1.00	0.91	1
84352_s_at²^{, 3}	U95-E	1	0.94	1.00	0.90	1.30	AA971429	0.60	1.00	0.82	1
82588_at²^{, 3}	U95-D	1	0.62	1.00	0.95	1.14	AI302459	0.60	1.00	0.82	1
211862_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF015451	0.80	0.80	0.80	1
210563_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	U97075	0.60	1.00	0.82	1
209939_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF005775	0.80	1.00	0.91	1
208485_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	NM_003879	0.60	1.00	0.82	1
210564_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF009619	0.80	0.88	0.84	1
211317_s_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF041461	0.80	0.88	0.84	1
209508_x_at²^{, 3}	U133-A	1	1.00	1.00	--	--	AF005774	0.80	0.88	0.84	1
211316_x_at²^{, 3}	U133-A	3	1.00	0.94	--	--	AF009616	0.80	0.88	0.84	1
214486_x_at²^{, 3}	U133-A	1	0.64	1.00	--	--	AF041459	0.80	0.88	0.84	1
237367_x_at²^{, 3}	U133-B	1	0.46	1.00	--	--	AA971429	0.60	1.00	0.82	1
211862_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210563_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209939_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
208485_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
210564_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211317_s_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
209508_x_at²	U133Plus2	1	1.00	1.00	--	--	--	--	--	--	--
211316_x_at²	U133Plus2	3	1.00	0.94	--	--	--	--	--	--	--
214486_x_at²	U133Plus2	1	0.64	1.00	--	--	--	--	--	--	--
237367_x_at²	U133Plus2	1	0.46	1.00	--	--	--	--	--	--	--

GeneDecks CFLAR for binary patterns associated with the probe-sets selected above

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About this table

Data from

(Publications) and GNF BioGPS
About these images
About these images

CGAP SAGE TAG: GAACTGCCTC

SOURCE GeneReport for Unigene cluster: Hs.390736
Expression variation in blood from EXPOLDB for CFLAR
UniProtKB/Swiss-Prot: CFLAR_HUMAN, O15519
Tissue specificity: Widely expressed. Higher expression in skeletal muscle, pancreas, heart,
kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8
is predominantly expressed in testis and skeletal muscle

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD and/or ⁵MGI Jun 06 2009, with possible further links to Flybase and/or WormBase, Gene Trees according to Ensembl)
About This Section

Orthologs for CFLAR gene from 5/7 species (see all 7 )

Organism	Gene	Locus	Description	Human Similarity	NCBI accessions
dog (Canis familiaris)	CFLAR¹	--	CASP8 and FADD-like apoptosis regulator	83.4(n) 78.03(a)	488471 XM_545592.2 XP_545592.2
chimpanzee (Pan troglodytes)	CFLAR¹	--	CASP8 and FADD-like apoptosis regulator	99.72(n) 99.37(a)	459872 XM_001171850.1 XP_001171850.1
cow (Bos taurus)	CFLAR¹	--	CASP8 and FADD-like apoptosis regulator	81.9(n) 74.63(a)	497199 NM_001012281.1 NP_001012281.1
rat (Rattus norvegicus)	Cflar¹	--	CASP8 and FADD-like apoptosis regulator	76.37(n) 68.99(a)	117279 NM_001033864.1 NP_001029036.1
mouse (Mus musculus)	Cflar^{1, 5}	1 (30.10 cM)⁵	CASP8 and FADD-like apoptosis regulator^{1, 5}	75.58(n)¹ 67.79(a)¹	12633¹ NM_207653.3¹ NP_997536.1¹ AI646576⁵ AK009498⁵ (see all 23)

About this table Species with no ortholog for CFLAR

ENSEMBL Gene Tree for CFLAR

(Paralogs according to ¹HomoloGene
and ²Ensembl, Pseudogenes according to ³Pseudogene.org)
About This Section

(According to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, and UniProtKB, Linkage Disequilibrium by HapMap, Genotyping Reagents from Applied Biosystems)
About This Section

10/210 NCBI SNPs in CFLAR are shown (see all 210 )
(Click for Applied Biosystems TaqMan ® Genotyping Assay) (see all 55)

AB	SNP ID	Valid	Chr 2 pos	Sequence	Recs	AA Chg	Type	More	Recs	Allele freq	Pop	Total sample	More
AB	Genomic Data				Transcription Data				Allele Frequencies
				--	--	--		--	--				--
--	rs2881929^1,2	A,F,H	201737405(+)	`catctG/Tcaagc`	1	--	ng3¹		4		EU EA WA	366
	rs13424615^1,2	F,H	201718346(+)	`TGAAGC/ATCCAT`	2	I/L	mis¹		4		EU EA WA	406
	rs10931931^1,2	C	201702785(+)	`TGGCCC/TGGAGC`	3	--	ut5¹ ese³		0	--	--	--	--
--	rs1060975^1,2	F	201736972(+)	`CTCACA/GCCTGT`	2	--	ut3¹		1		MN	184
--	rs3201947^1,2	F	201737000(+)	`AGGCCA/GAGGAG`	2	--	ut3¹		1		MN	184
--	rs1138232^1,2	F	201737024(+)	`AGGTCA/GGGAGT`	2	--	ut3¹		1		MN	184
	rs12721504^1,2	H	201733733(+)	`GGTGGA/TTGGGC`	2	D/V	mis¹		5		EU EA WA	462
	rs1594^1,2	A,C,F,H	201733866(-)	`AGGGAT/CGGTGA`	2	P/P	syn¹		18		EA MN NA EU WA	3002
	rs3769829^1,2	F,H	201718378(-)	`TCCTTA/CAGTCT`	2	L/L	syn¹ ese³		5		EA EU WA	1910
	rs11892476^1,2	C,H	201733686(+)	`AACTAT/CGTGGT`	2	Y/Y	syn¹ ese³		4		EU EA WA	420

About this table

HapMap Linkage Disequilibrium images for CFLAR (up to first 250kb)

(in which this Gene is Involved, According to OMIM, UniProtKB, Novoseek, PharmGKB, Genatlas, GeneTests, Blood group antigen gene mutations by BGMUT, HGMD, GAD, HuGE Navigator, BCGD, and/or TGDB.)
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OMIM: 603599

10/80 Novoseek disease relationships for CFLAR gene (see all 80 )

Disease	Score	Articles	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	76.52	48	9380701 (1), 11359904 (1), 15059915 (1), 17011514 (1) (see all 35)
tumors	67.21	153	19223508 (6), 11145953 (5), 18309685 (5), 16820908 (3) (see all 81)
cancer	57.47	72	18288942 (4), 15833082 (2), 16441226 (2), 18202702 (2) (see all 39)
cadasil	46.38	1	19419383 (1)
malignant glioma	44.97	3	12496285 (1), 19158480 (1)
leukemia b-cell	41.08	3	15851579 (1), 16140959 (1), 16105982 (1)
colon cancer	40.45	27	15832422 (6), 16373718 (3), 18314627 (3), 16052516 (3) (see all 9)
prostate cancer	40.42	46	19095249 (7), 16537561 (4), 18790747 (4), 17332355 (3) (see all 14)
ovarian cancer	38.93	15	15258564 (3), 12730675 (1), 18559494 (1), 17136319 (1) (see all 6)
leukemia lymphocytic chronic	37.15	2	12649137 (1), 16204629 (1)

About this table

Human Genome Epidemiology Navigator: CFLAR (5 documents)

(Possibly Related Articles in Doctor's Guide)
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(in PubMed. Associations of this gene to articles via ¹Novoseek, ²HGNC, ³Entrez Gene, ⁴UniProtKB/Swiss-Prot, ⁵UniProtKB/TrEMBL, ⁶GAD, and/or ⁷PharmGKB)
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10/663 PubMed articles for CFLAR gene (see all 663 ):

Casper is a FADD- and caspase-related inducer of apoptosis. (PubMed id 9208847)^{1, 2, 3, 4} Shu H.-B.... Goeddel D.V. (1997)
Inhibition of death receptor signals by cellular FLIP. (PubMed id 9217161)^{1, 2, 3, 4} Irmler M....Tschopp J. (1997)
CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis. (PubMed id 9380701)^{1, 3, 4} Inohara N.... Nunez G. (1997)
The role of c-FLIP in modulation of CD95-induced apoptosis. (PubMed id 9880531)^{1, 3, 4} Scaffidi C.... Peter M.E. (1999)
Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis. (PubMed id 10227994)^{1, 3, 4} Algeciras-Schimnich A.... Paya C.V. (1999)
Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex. (PubMed id 10200473)^{1, 3, 4} Rasper D.M....Nicholson D.W. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{3, 4} Gerhard D.S....Malek J. (2004)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{3, 4} Hillman R.T.... Brenner S.E. (2004)
Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2. (PubMed id 11161814)^{3, 4} Hadano S....Hayden M.R. (2001)
FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. (PubMed id 9228018)^{3, 4} Srinivasula S.M.... Alnemri E.S. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Free Text

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, and/or H-InvDB)
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Entrez Gene: 8837	HGNC: 1876	AceView: CFLAR	Ensembl:ENSG00000003402	euGenes: HUgn8837
ECgene: CFLAR	H-InvDB: CFLAR

(According to HUGE)
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(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
ATLAS Chromosomes in Cancer entry for CFLAR	Genetics and Cytogenetics in Oncology and Haematology

Licensable Technologies for CFLAR
(Available from WIS Yeda, Salk, Tufts)

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(Reagents available from Applied Biosystems, Antibodies and assays by Cell Signaling Technology, Abcam, Novus Biologicals,
Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich,
Enzo Life Sciences, and/or Tocris Bioscience)
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Products for CFLAR:

TaqMan ® Gene Expression Assays

TaqMan ® Genotyping Assays

Free SNP selection tool

Invitrogen iPath Pathways	Invitrogen BLOCK-iT™ RNAi
Invitrogen Antibodies	Invitrogen Assays
Invitrogen Clones	Invitrogen Q-PCR Products
Invitrogen Human Recombinant Kinases	Invitrogen Custom Antibody and Peptide Service
Invitrogen Proteins / Assays / Screening Services	Search Invitrogen catalog for CFLAR-related products

	Millipore Custom Antibody & Bulk Services
	Millipore Preclinical / Clinical Development Services
	Millipore Immunoassay Services
	Millipore Target Screening & Profiling Services

	Predesigned and custom siRNAs for CFLAR		Antibodies for CFLAR
	Explore super-pooled esiRNAs		Browse proteins at Sigma-Aldrich
	Lentivirus-delivered shRNAs for CFLAR		Browse small molecules at Sigma-Aldrich
	"Your Favorite Gene" Pathways		feedback

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	Multiplex/Array Assay Kits & Reagents		ELISpot Kits & Development Modules
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	Recombinant Proteins (FLIP delta + gamma, FLIP)
	Antibodies (FLIP delta + gamma, FLIP)

	Tagged/untagged cDNA clones
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	Western blot validated antibodies
	shRNA in GFP-retroviral vector

Search Tocris compounds for CFLAR

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Antibodies for CFLAR

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CFLAR Gene

protein-coding GIFtS: 63

Aliases &
Descriptions
for CFLAR

Summaries
for CFLAR

Genomic Location
for CFLAR

Proteins
for CFLAR

Protein Domains/
Families
for CFLAR

Gene Function
for CFLAR

Pathways & Interactions
for CFLAR

Drugs & Compounds
for CFLAR

Transcripts
for CFLAR

Expression
for CFLAR

Orthologs
for CFLAR

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for CFLAR

SNPs/Variants
for CFLAR

Disorders & Mutations
for CFLAR

Medical News
for CFLAR

Publications
for CFLAR

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Genome Databases showing CFLAR

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Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

CFLAR (Gene Symbol)
CASH
CASP8AP1
CASPER
CLARP
Casper
FLAME
FLAME-1
FLAME1
FLIP
I-FLICE
MRIT
Usurpin
c-FLIP
c-FLIPL
c-FLIPR
c-FLIPS
CASP8 and FADD-like apoptosis regulator
Caspase homolog
Caspase-eight-related protein
Caspase-like apoptosis regulatory protein
Cellular FLICE-like inhibitory protein
FADD-like anti-apoptotic molecule
FADD-like antiapoptotic molecule 1
Inhibitor of FLICE
MACH-related inducer of toxicity
caspase-related inducer of apoptosis
usurpin beta

CFLAR Gene

protein-coding GIFtS: 63

Aliases & Descriptionsfor CFLAR

Summariesfor CFLAR

Genomic Locationfor CFLAR

Proteinsfor CFLAR

Protein Domains/Familiesfor CFLAR

Gene Functionfor CFLAR

Pathways & Interactionsfor CFLAR

Drugs & Compoundsfor CFLAR

Transcriptsfor CFLAR

Expression for CFLAR

Orthologsfor CFLAR

Paralogsfor CFLAR

SNPs/Variantsfor CFLAR

Disorders & Mutationsfor CFLAR

Medical Newsfor CFLAR

Publicationsfor CFLAR

Search for CFLAR

Genome Databases showing CFLAR

Other Databases showing CFLAR

Specialized Databases showing CFLAR

Licensable Technologiesfor CFLAR

Servicesfor CFLAR

Gene Index: 3 5 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

Aliases &
Descriptions
for CFLAR

Summaries
for CFLAR

Genomic Location
for CFLAR

Proteins
for CFLAR

Protein Domains/
Families
for CFLAR

Gene Function
for CFLAR

Pathways & Interactions
for CFLAR

Drugs & Compounds
for CFLAR

Transcripts
for CFLAR

Expression
for CFLAR

Orthologs
for CFLAR

Paralogs
for CFLAR

SNPs/Variants
for CFLAR

Disorders & Mutations
for CFLAR

Medical News
for CFLAR

Publications
for CFLAR

Licensable Technologies
for CFLAR

Services
for CFLAR