Home
GeneCards Guide
Suite
- MalaCards
- GeneALaCart
- GeneDecks
- GeneIP
- GeneLoc
Terms and Conditions
- Terms of Use
- 3rd Party Notice
About Us
User Feedback
Mirror sites

Set Analyses:

Generates a file of GeneCards annotations for your list of genes

Advanced Search

Search By

Section (entire)

for

All GeneCards Within gene subset (to enable gene prioritization):
or upload a file of gene symbols

Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CFLAR Gene

protein-coding GIFtS: 65
GCID: GC02P201980

CASP8 and FADD-like apoptosis regulator

(Previous symbol: CASP8AP1)

Explore 120 diseases affiliated with
CFLAR via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
CASP8 And FADD-Like Apoptosis Regulator¹ ²		Inhibitor Of FLICE² ³
CASH¹ ² ³ ⁵		FLAME-1² ³
CASP8AP1¹ ² ³		FADD-Like Antiapoptotic Molecule 1² ³
CLARP¹ ² ³		MACH-Related Inducer Of Toxicity² ³
Casper¹ ² ³		FLAME1² ⁵
I-FLICE¹ ² ³		C-FLIPL¹
MRIT¹ ² ³		C-FLIPR¹
C-FLIP¹		C-FLIPS¹
FLIP¹ ² ⁵		Caspase-Related Inducer Of Apoptosis²
FLAME¹ ²		FADD-Like Anti-Apoptotic Molecule²
Caspase Homolog² ³		Usurpin Beta²
Caspase-Eight-Related Protein² ³		Usurpin³
Caspase-Like Apoptosis Regulatory Protein² ³		CASPER⁵
Cellular FLICE-Like Inhibitory Protein² ³

External Ids:	HGNC: 1876¹	Entrez Gene: 8837²	Ensembl: ENSG00000003402⁷	OMIM: 603599⁵	UniProtKB: O15519³

Export aliases for CFLAR gene to outside databases

Previous GC identifers: GC02P200197 GC02P200705 GC02P201944 GC02P202183 GC02P201806 GC02P201689 GC02P193832

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CFLAR:

The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the

encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several

transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more

variants exists. (provided by RefSeq, Feb 2011)

UniProtKB/Swiss-Prot: CFLAR_HUMAN, O15519

Function: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death

pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is

likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of

caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce

TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity

Gene Wiki entry for CFLAR

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_005403.17

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CFLAR gene promoter:
TBP STAT1 p53
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CFLAR promoter sequence

Search SABiosciences Chromatin IP Primers for CFLAR

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CFLAR

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q33-q34 Ensembl cytogenetic band: 2q33.1 HGNC cytogenetic band: 2q33-q34

CFLAR Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CFLAR gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P201980: view genomic region (about GC identifiers)

Start:	201,980,816 bp from pter	End:	202,029,033 bp from pter
Size:	48,218 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CFLAR_HUMAN, O15519 (See protein sequence)

Recommended Name: CASP8 and FADD-like apoptosis regulator precursor

Size: 480 amino acids; 55344 Da

Subunit: TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6,

FADD and caspase-8. A proteolytic fragment (p43) stays associated with the DISC. Also interacts with caspase-10,

caspase-3, TRAF1, TRAF2 and Bcl-X(L) (in vitro). Interacts with HBV protein X

2 PDB 3D structures from and Proteopedia for CFLAR:

3H11 (3D)

3H13 (3D)

Secondary accessions: B4DJE0 B7Z9F9 O14673 O14674 O14675 O15137 O15138 O15356 O15510 O43618 O43619

O43620 O60458 O60459 Q53TS6 Q54AF1 Q96TE4 Q9UEW1

Alternative splicing: 15 isoforms: O15519-1 O15519-2 O15519-3 O15519-4 O15519-5 O15519-6 O15519-7 O15519-8

O15519-9 O15519-10 O15519-11 O15519-12 O15519-13 O15519-14 O15519-15 (May be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay)

Explore the universe of human proteins at neXtProt for CFLAR: NX_O15519

Post-translational modifications:

Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and

p12¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15519

CFLAR Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (8 alternative transcripts):

NP_001120655.1 NP_001120656.1 NP_001189444.1 NP_001189445.1 NP_001189446.1 NP_001189447.1 NP_001189448.1 NP_003870.4

ENSEMBL proteins:

ENSP00000312455 ENSP00000413270 ENSP00000339335 ENSP00000345807 ENSP00000342809

ENSP00000378580 ENSP00000411897 ENSP00000391029 ENSP00000399420 ENSP00000398551

ENSP00000409570 ENSP00000412882 ENSP00000406775 ENSP00000411535 ENSP00000347757

ENSP00000339326

Human Recombinant Protein Products:

	Browse Purified and Recombinant Proteins at EMD Millipore
	R&D Systems Recombinant & Natural Proteins for CFLAR (FLIP)
	Browse recombinant and purified proteins available from Enzo Life Sciences
	OriGene Purified Protein: CFLAR OriGene Protein Over-expression Lysate (see all 2): CFLAR OriGene Custom Protein Services for CFLAR
	GenScript Custom Purified and Recombinant Proteins Services for CFLAR
	Novus Biologicals CFLAR Proteins Novus Biologicals CFLAR Lysates
	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CFLAR
	Uscn Proteins for CFLAR

Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	18073330
GO:0031264	death-inducing signaling complex	IDA	--

CFLAR for ontologies About GeneDecksing

CFLAR Antibody Products:

	EMD Millipore Mono- and Polyclonal Antibodies for the study of CFLAR
	R&D Systems Antibodies for CFLAR (FLIP)
	Cell Signaling Technology (CST) Antibodies for CFLAR
	OriGene Antibodies (see all 3): CFLAR OriGene Custom Antibody Services for CFLAR
	GenScript Custom Superior Antibodies Services for CFLAR
	Novus Biologicals CFLAR Antibodies
	Search for Antibodies for CFLAR at Abcam
	Uscn Antibodies for CFLAR
	ThermoFisher Antibody for CFLAR

Assay Products for CFLAR:

	Browse Kits and Assays available from EMD Millipore
	OriGene Custom Immunoassay Development Browse OriGene Fluorogenic Cell Assay Kits
	Browse R&D Systems for biochemical assays
	GenScript Custom Assay Services for CFLAR
	Browse Enzo Life Sciences for kits & assays
	Uscn ELISAs and CLIAs for CFLAR

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CFLAR for domains About GeneDecksing

5/6 InterPro domains/families (see all 6):

IPR001309 Pept_C14_ICE_p20

IPR011029 DEATH-like_dom

IPR015917 Pept_C14_p45_core

IPR011600 Pept_C14_cat

IPR002398 Pept_C14_p45

Graphical View of Domain Structure for InterPro Entry O15519

ProtoNet protein and cluster: O15519

UniProtKB/Swiss-Prot: CFLAR_HUMAN, O15519

Domain: The caspase domain lacks the active sites residues involved in catalysis

Similarity: Belongs to the peptidase C14A family

Similarity: Contains 2 DED (death effector) domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CFLAR_HUMAN, O15519

Function: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death

pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is

likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of

caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce

TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity

Induction: Repressed by IL2/interleukin-2 after TCR stimulation, during progression to the S phase of the cell cycle

Genatlas biochemistry entry for CFLAR:

caspase eight related,predominantly expressed in skeletal muscle,pancreas,heart,activated by Fas ligand,interacting

with FADD and promoting apoptosis

miRNA Products:		miRTarBase miRNAs that target CFLAR: hsa-mir-346 (MIRT004228)

		OriGene 3'-UTR Clone (see all 3): CFLAR Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CFLAR
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate CFLAR:
		hsa-miR-495 hsa-miR-7-2* hsa-miR-370 hsa-miR-7-1* hsa-miR-802 hsa-miR-24 hsa-miR-3145-3p hsa-miR-192*

		SwitchGear 3'UTR luciferase reporter plasmid: CFLAR 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CFLAR (see all 7) OriGene shRNA RFP: CFLAR OriGene siRNA: CFLAR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CFLAR

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CFLAR

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CFLAR (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CFLAR (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 8): CFLAR (NM_003879)
		Browse Sino Biological Human cDNA Clones
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CFLAR
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CFLAR

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CFLAR
		Search LifeMap BioReagents cell lines for CFLAR

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFLAR

Gene Ontology (GO): 4 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0002020	protease binding	IPI	9208847
GO:0004197	cysteine-type endopeptidase activity	IEA	--
GO:0005515	protein binding	IPI	9208847
GO:0008047	enzyme activator activity	IDA	9208847

CFLAR for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CFLAR:

Decreased nuclei size in G2M

Synthetic lethal with gemcitab

Animal Models:
Mouse knock-outs for CFLAR: Cflar^tm1.2Pope Cflar^tm1Mak
9 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Cflar):

cardiovascular system	cellular	embryogenesis	growth/size	hematopoietic system
homeostasis/metabolism	immune system	mortality/aging	muscle

CFLAR for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/13 super-pathways (see all 13) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

TWEAK Pathway

HIV-1 Nef- Negative effector of Fas and TNF-alpha	0.42	TRAIL Pathway	0.40
Apoptosis and survival TNFR1 signaling pathway	0.40	Apoptosis through Death Receptors	0.32
Apoptosis and survival_TNFR1 signaling pathway	0.40	Fas Signaling	0.29

Apoptosis and survival_Caspase cascade

	Apoptosis and survival_FAS signaling cascades	0.44			FAS pathway and Stress induction of HSP regulation	0.33
	Apoptosis and survival FAS signaling cascades	0.44

Apoptotic Pathways in Synovial Fibroblasts

Apoptotic Pathways in Synovial Fibroblasts

1.00

Cellular Apoptosis Pathway

0.65

Apoptosis Modulation and Signaling

Apoptosis Modulation and Signaling

1.00

Apoptosis

0.38

TRAIL signaling pathway

TRAIL signaling pathway

1.00

FAS (CD95) signaling pathway

0.30

Pathway sources
See GeneCards unified pathways
Show all pathways

2 EMD Millipore Pathways for CFLAR

	Apoptosis and survival TNFR1 signaling pathway
	Apoptosis and survival FAS signaling cascades

5/8 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CFLAR (see all 8)

	Molecular Mechanisms of Cancer
	TRAIL Pathway
	Apoptotic Pathways in Synovial Fibroblasts
	Fas Signaling
	all-trans-Retinoic Acid Mediated Apoptosis

1 Cell Signaling Technology (CST) Pathway for CFLAR

Apoptosis and Autophagy

2 GeneGo (Thomson Reuters) Pathways for CFLAR

	Apoptosis and survival FAS signaling cascades
	Apoptosis and survival TNFR1 signaling pathway

5/8 BioSystems Pathways for CFLAR (see all 8)

	Apoptosis
	Apoptosis Modulation and Signaling
	FAS pathway and Stress induction of HSP regulation
	TNF-alpha/NF-kB Signaling Pathway
	TRAIL signaling pathway

2 Kegg Pathways (Kegg details for CFLAR):

	Apoptosis
	Chagas disease (American trypanosomiasis)

CFLAR for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CFLAR

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/66 Interacting proteins for CFLAR (O15519^{2, 3} ENSP00000312455⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 66)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
MAP2K7	O14733²^,³, ENSP00000381066⁴	MINT-3391541 MINT-3391468 I2D: score=1 STRING: ENSP00000381066
CASP8	Q14790²^,³, ENSP00000351273⁴	MINT-4055334 I2D: score=5 STRING: ENSP00000351273
MAP2K1	Q02750², ENSP00000302486⁴	MINT-3391491 MINT-3391418 MINT-3391521 STRING: ENSP00000302486
MAP2K4	P45985²^,³, ENSP00000262445⁴	MINT-3391445 I2D: score=1 STRING: ENSP00000262445
BCL2L1	Q07817³, ENSP00000302564⁴	I2D: score=4 STRING: ENSP00000302564

About this table

Gene Ontology (GO): 5/17 biological process terms (GO ID links to tree view) (see all 17): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0006508	proteolysis	IEA	--
GO:0006915	apoptotic process	IEA	--
GO:0007519	skeletal muscle tissue development	ISS	--
GO:0014732	skeletal muscle atrophy	ISS	--
GO:0014842	regulation of satellite cell proliferation	ISS	--

CFLAR for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CFLAR for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CFLAR
10/68 Novoseek chemical compound relationships for CFLAR gene (see all 68) About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
cycloheximide	63.4	47	11309649 (3), 11359904 (2), 18289527 (2), 10919673 (2) (see all 23)
suberoylanilide hydroxamic acid	62.4	10	18765530 (3), 19483104 (2), 18065490 (1), 17690692 (1)
mg 132	61.5	12	16537561 (2), 11359904 (1), 16082182 (1), 16037944 (1) (see all 10)
bortezomib	60.2	7	17659339 (2), 17897295 (1), 19100720 (1), 16024631 (1) (see all 5)
ly294002	56.3	9	11440972 (2), 19426671 (1), 11145953 (1), 14605879 (1) (see all 8)
flavopiridol	51.9	20	16820931 (2), 15385934 (1), 18065490 (1), 16951203 (1) (see all 5)
gw9662	50.6	2	17172826 (1)
3,3'-diindolylmethane	50.6	5	16373712 (2), 17071604 (2)
doxorubicin	49.1	18	15638938 (5), 17106251 (4), 17513603 (2), 12496481 (2) (see all 8)
bisindolylmaleimide	46.4	11	10828032 (3), 11877293 (1), 12163389 (1), 15928597 (1)

Search CenterWatch for drugs/clinical trials and news about CFLAR

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CFLAR gene (8 alternative transcripts):

NM_001127183.2 NM_001127184.2 NM_001202515.1 NM_001202516.1 NM_001202517.1 NM_001202518.1 NM_001202519.1 NM_003879.5

Unigene Cluster for CFLAR:

CASP8 and FADD-like apoptosis regulator

Hs.390736 [show with all ESTs]

Unigene Representative Sequence: NM_001202519

18/26 Ensembl transcripts including schematic representations, and UCSC links where relevant (see all 26):

ENST00000309955(uc002uxb.4 uc010zhk.2 uc010zhl.2 uc002uxc.4 uc010fsx.3 uc010fsy.3 uc002uxf.3 uc002uxg.3)

ENST00000443227 ENST00000341222(uc002uwz.3) ENST00000341582 ENST00000342795(uc021vuw.1)

ENST00000395148(uc002uwy.3) ENST00000441224 ENST00000433445 ENST00000423241(uc010fsw.2 uc002uxd.4)

ENST00000490965 ENST00000439154 ENST00000425030 ENST00000417748 ENST00000440180(uc002uxe.2)

ENST00000461820 ENST00000457277(uc010zhm.2 uc010fsz.3) ENST00000461422

ENST00000494258

miRNA Products:		OriGene 3'-UTR Clone (see all 3): CFLAR Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CFLAR
		8 QIAGEN miScript miRNA Assays for microRNAs that regulate CFLAR:
		hsa-miR-495 hsa-miR-7-2* hsa-miR-370 hsa-miR-7-1* hsa-miR-802 hsa-miR-24 hsa-miR-3145-3p hsa-miR-192*

		SwitchGear 3'UTR luciferase reporter plasmid: CFLAR 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CFLAR (see all 7) OriGene shRNA RFP: CFLAR OriGene siRNA: CFLAR
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CFLAR

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CFLAR (see all 8) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CFLAR (see all 3) OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 8): CFLAR (NM_003879)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CFLAR
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CFLAR

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CFLAR Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CFLAR
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CFLAR
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CFLAR

Additional cDNA sequence:

AB209600.1 AF005774.1 AF005775.1 AF009616.1 AF009617.1 AF009618.1 AF009619.1 AF010127.1

AF015450.1 AF015451.1 AF015452.1 AF041458.1 AF041459.1 AF041460.1 AF041461.1 AF041462.1

AK124664.1 AK125394.1 AK289913.1 AK296036.1 AK297387.1 AK304585.1 AK308767.1 AK315208.1

AK315924.1 AL365413.1 BC001602.1 BC148237.1 BC148289.1 BT006751.1 U85059.1 U97074.1

U97075.1 Y14039.1 Y14040.1

24/50 DOTS entries (see all 50):

DT.456302 DT.92325571 DT.100827245 DT.436456 DT.95292598 DT.91755054 DT.95361165 DT.65288187

DT.120956660 DT.91678225 DT.91833890 DT.432406 DT.100827248 DT.92065440 DT.120956626 DT.92067137

DT.87002404 DT.91755061 DT.100827253 DT.100827246 DT.100827247 DT.91755056 DT.95354587 DT.100827251

24/324 AceView cDNA sequences (see all 324):

BM838613 BQ709107 F01470 BF895815 CA949933 BM827180 AF009616 BX956432

AF015451 BU685922 AU117908 AA453766 BM916499 BF593765 CD516316 BU754272

BP341411 AA453850 BU617264 BQ706783 CA306141 BU608142 CA448751 T30922

GeneLoc Exon Structure

5/22 Alternative Splicing Database (ASD) splice patterns (SP) for CFLAR (see all 22) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	^	4	^	5	^	6a	·	6b	·	6c	·	6d	·	6e	·	6f	^	7	^	8a	·	8b	·	8c	·	8d	·	8e	^	9a	·	9b	·	9c	·	9d	^	10	^	11	^
SP1:							-		-		-		-		-		-		-										-		-		-																-		-
SP2:													-		-		-		-										-		-		-																-		-
SP3:																													-		-		-																-		-
SP4:																													-		-		-																-		-
SP5:																													-		-		-																-		-

ExUns:	12a	·	12b	·	12c	^	13a	·	13b	·	13c	^	14	^	15	^	16	^	17	^	18a	·	18b	^	19	^	20a	·	20b	·	20c
SP1:	-				-		-		-		-								-						-
SP2:	-				-		-		-		-								-						-
SP3:	-				-		-		-		-								-
SP4:	-				-		-		-		-
SP5:	-				-		-		-		-								-		-		-		-

ECgene alternative splicing isoforms for CFLAR

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CFLAR expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAACTGCCTC

About this image

CFLAR expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Brain

Choroid Plexus

Brain

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Definitive endoderm-like cells (A scalable, suspensi...)

See CFLAR Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CFLAR

SOURCE GeneReport for Unigene cluster: Hs.390736

UniProtKB/Swiss-Prot: CFLAR_HUMAN, O15519

Tissue specificity: Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and

peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and

skeletal muscle

SABiosciences Expression via Pathway-Focused PCR Arrays including CFLAR (see all 13):

G-Protein-Coupled Receptor Signaling PathwayFinder in human mouse rat

Cancer PathwayFinder in human mouse rat

Inflammasomes in human mouse rat

Liver Cancer in human mouse rat

Apoptosis in human mouse rat

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CFLAR Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CFLAR
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CFLAR
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CFLAR

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFLAR

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CFLAR gene from 4/10 species (see all 10) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cflar^{1 , 5}	CASP8 and FADD-like apoptosis regulator^{1, 5}	75.72(n)¹ 68(a)¹		1 (29.16 cM)⁵ 12633¹ NM_207653.3¹ NP_997536.1¹ 58711508⁵
chicken (Gallus gallus)	Aves	CFLAR¹	CASP8 and FADD-like apoptosis regulator	58.05(n) 51.28(a)		424080 NM_001202462.1 NP_001189391.1
lizard (Anolis carolinensis)	Reptilia	CFLAR⁶	--	44(a)	1 ↔ 1	GL343478.1(395470-416751)
zebrafish (Danio rerio)	Actinopterygii	AF448261.1²	--	72.07(n)		373114 AF448261.1

ENSEMBL Gene Tree for CFLAR (if available)
TreeFam Gene Tree for CFLAR (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs72931011^1,2	C,F,	--	193830674(+)	`GGTGGC/TATGCT`	5	--	us2k¹		1		WA	118
rs72931013^1,2	C,	--	193831051(+)	`AAAAAA/C/GGGTTG`	5	--	us2k¹		2		NA	122
rs75208666^1,2	F,	--	193832369(+)	`CGCGTG/AGAACT`	5	--	us2k¹		1		NA	120
rs78384838^1,2	F,	--	193832406(+)	`GCATAC/GTCAGT`	5	--	ut5¹		1		WA	118
rs76524221^1,2		--	193833882(+)	`TGCTTT/CAGAGA`	6	--	us2k¹ int¹		1		WA	118
rs199852664^1,2	C	--	193833999(+)	`AAGATC/TTNNNN`	6	--	us2k¹ int¹		0	--	--	--	--
rs2881928^1,2	C,F,A,	--	193834070(+)	`cactaC/Tctctg`	6	--	int¹ us2k¹		5		NA WA CSA	8
rs10165178^1,2	C	--	193834140(+)	`gctgaG/Aattac`	6	--	us2k¹ int¹		1		NA	2
rs6712963^1,2	C,F,A,	--	193834219(+)	`gtctgG/Atctcg`	6	--	us2k¹ int¹		2		NA WA	4
rs72931016^1,2	C,	--	193834583(+)	`CCGAAA/GGTCTT`	6	--	int¹ us2k¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CFLAR (201980816 - 202029033 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CFLAR: --
Human Gene Mutation Database (HGMD): CFLAR

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CFLAR

DNA2.0 Custom Variant and Variant Library Synthesis for CFLAR

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CFLAR for disorders           About GeneDecksing

OMIM gene information: 603599    OMIM disorders: --

20/120 diseases for CFLAR (see all 120):    About MalaCards

limb-girdle muscular dystrophy diffuse large b-cell lymphoma langerhans-cell histiocytosis thrombotic thrombocytopenic purpura

cervical intraepithelial neoplasia amyotrophic lateral sclerosis (als) molluscum contagiosum large granular lymphocyte leukemia

non-small cell lung carcinoma amyotrophic lateral sclerosis b-cell lymphomas salivary gland cancer

anaplastic large cell lymphoma systemic lupus erythematosus actinic keratosis non-hodgkin lymphoma

soft tissue sarcoma cadasil lateral sclerosis systemic lupus erythematosus, association with

10/81 Novoseek disease relationships for CFLAR gene (see all 81) About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
necrosis	77	55	9380701 (1), 11359904 (1), 15059915 (1), 17011514 (1) (see all 39)
tumors	68.1	174	19223508 (6), 11145953 (5), 18309685 (5), 19846923 (3) (see all 93)
cancer	59.3	88	18288942 (4), 19773432 (3), 19932761 (2), 15833082 (2) (see all 46)
colon cancer	46.9	28	15832422 (6), 16373718 (3), 18314627 (3), 16052516 (3) (see all 9)
malignant glioma	46.4	6	19398149 (2), 12496285 (1), 19158480 (1), 19409438 (1)
ovarian cancer	44.9	24	19802016 (3), 19959214 (3), 15258564 (3), 20227749 (2) (see all 10)
cadasil	44.3	1	19419383 (1)
prostate cancer	39.8	46	19095249 (7), 16537561 (4), 18790747 (4), 17332355 (3) (see all 14)
leukemia b-cell	38.9	3	15851579 (1), 16140959 (1), 16105982 (1)
hodgkin disease	36.1	25	15354734 (7), 16441226 (2), 17659339 (2), 18042067 (2) (see all 9)

Human Genome Epidemiology (HuGE) Navigator: CFLAR (18 documents)

Export disorders for CFLAR gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CFLAR gene, integrated from 9 sources (see all 805):
(articles sorted by number of sources associating them with CFLAR)

Utopia: connect your pdf to the dynamic
world of online information

Casper is a FADD- and caspase-related inducer of apoptosis. (PubMed id 9208847)^{1, 2, 3, 9} Shu H.-B.... Goeddel D.V. (1997)
Inhibition of death receptor signals by cellular FLIP. (PubMed id 9217161)^{1, 2, 3, 9} Irmler M.... Tschopp J. (1997)
CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis. (PubMed id 9380701)^{1, 2, 9} Inohara N.... Nunez G. (1997)
The role of c-FLIP in modulation of CD95-induced apoptosis. (PubMed id 9880531)^{1, 2, 9} Scaffidi C.... Peter M.E. (1999)
Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis. (PubMed id 10227994)^{1, 2, 9} Algeciras-Schimnich A.... Paya C.V. (1999)
Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex. (PubMed id 10200473)^{1, 2, 9} Rasper D.M....Nicholson D.W. (1998)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
An unappreciated role for RNA surveillance. (PubMed id 14759258)^{1, 2} Hillman R.T.... Brenner S.E. (2004)
Cloning and characterization of three novel genes, ALS2CR1, ALS2CR2, and ALS2CR3, in the juvenile amyotrophic lateral sclerosis (ALS2) critical region at chromosome 2q33-q34: candidate genes for ALS2. (PubMed id 11161814)^{1, 2} Hadano S.... Hayden M.R. (2001)
FLAME-1, a novel FADD-like anti-apoptotic molecule that regulates Fas/TNFR1-induced apoptosis. (PubMed id 9228018)^{1, 2} Srinivasula S.M.... Alnemri E.S. (1997)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 8837	HGNC: 1876	AceView: CFLAR	Ensembl:ENSG00000003402	euGenes: HUgn8837
ECgene: CFLAR	Kegg: 8837	H-InvDB: CFLAR

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CFLAR	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CFLAR	Genetics and Cytogenetics in Oncology and Haematology

Intellectual Property for CFLAR gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CFLAR gene:
Search GeneIP for patents involving CFLAR

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section

	Browse Small Molecules at EMD Millipore
	Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
	Browse for Gene Knock-down Tools from EMD Millipore
	Browse Purified and Recombinant Proteins at EMD Millipore
	Browse Kits and Assays available from EMD Millipore
	EMD Millipore Mono- and Polyclonal Antibodies for the study of CFLAR

	EMD Millipore Custom Antibody & Bulk Services
	EMD Millipore Preclinical / Clinical Development Services
	EMD Millipore Immunoassay Services
	EMD Millipore Target Screening & Profiling Services

	Antibodies for CFLAR (FLIP)		Browse Cell Culture Products
	Browse ELISAs		Browse Flow Cytometry Kits
	Browse Primer Pairs		Browse Kinase Activity Assays/Reagents
	Browse ELISpot Kits/Development Modules		Browse TFB/Immunoprecipitation Assays
	Browse Apoptosis Detection Kits/Reagents		Browse Ubiquitin Proteasome Pathway (UPP) Assay Kits/Reagents
	Browse DNA Damage/Repair Kits/Reagents		Browse Multiplex/Array Assay Kits/Reagents
	Browse Cell Selection/Detection Kits/Reagents		Browse Secondary Antibodies/Controls/Staining Reagents
	Browse Phosphatase Activity Assays/Reagents		Recombinant/Natural Proteins for CFLAR (FLIP)

	OriGene Antibodies for CFLAR		OriGene shRNA RFP for CFLAR
	OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CFLAR		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CFLAR
	OriGene Protein Over-expression Lysate for CFLAR		Browse OriGene Fluorogenic Cell Assay Kits
	OriGene siRNA for CFLAR		OriGene 3'-UTR Clone for CFLAR
	OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CFLAR		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CFLAR
	Browse OriGene GFP tagged cDNA clones in CMV expression vector		Browse OriGene MicroRNA Expression Plasmids
	Browse OriGene basic RS shRNAs		Browse OriGene validated miRNA SYBR primer pairs
	OriGene Purified Protein for CFLAR		OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
	OriGene Custom Antibody Services for CFLAR		OriGene Custom Protein Services for CFLAR
	OriGene Custom Immunoassay Development

	QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CFLAR
	Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CFLAR
	QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CFLAR
	QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CFLAR
	QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CFLAR
	QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CFLAR

	GenScript Custom Purified and Recombinant Proteins Services for CFLAR		GenScript cDNA clones with any tag delivered in your preferred vector for CFLAR
	GenScript Custom Assay Services for CFLAR		GenScript Custom Superior Antibodies Services for CFLAR
	GenScript Custom overexpressing Cell Line Services for CFLAR		CloneReady with Over 120,000 Genes
	Gene Synthesis: Any Gene in Any Vector		Vector-based siRNA and miRNA, Ready for Transfection
	Gene Mutant Library, Variants up to 10^11		Plasmid Preparation
	Custom Peptide Services

Antibodies & Assays for CFLAR

	Regulatory tfbs in CFLAR promoter
	Search Chromatin IP Primers for CFLAR
	RT² qPCR Primer Assay in human, mouse, rat CFLAR
	GNC Network for CFLAR
	SABiosciences PCR Arrays including human, mouse, rat CFLAR

Search Tocris compounds for CFLAR

	Browse Sino Biological Proteins and Antibodies
	Browse Sino Biological cDNA Clones
	Antibodies/Proteins Production Services
	Rabbit Monoclonal Antibody Platform
	Bulk Purchasing

Search www.enzolifesciences.com for proteins, assays, substrates, inhibitors & antibodies

	Novus Tissue Slides
	CFLAR antibodies
	CFLAR proteins
	CFLAR lysates

	Search for Antibodies for CFLAR at Abcam
	See all of Abcam's Antibodies, Kits and Proteins for CFLAR
	Custom Antibody / Protein Production Service
	Bulk Purchasing
	Advantages of Rabbit Monoclonal antibodies
	Abcam protocols and scientific support

Recombinant Protein for CFLAR

CFLAR Proteins, Antibodies, CLIAs, and ELISAs

Search LifeMap BioReagents cell lines for CFLAR

	Gene Synthesis
	Protein Engineering
	Variant Library Synthesis
	Codon Optimization
	Protein Production and Purification

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFLAR

	SwitchGear 3'UTR luciferase reporter plasmids for CFLAR
	SwitchGear Promoter luciferase reporter plasmids for CFLAR

ThermoFisher Antibody for CFLAR

Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CFLAR

GeneCards Homepage - Last full update: 19 Mar 2013 - Incrementals: 21 Mar 2013 , 15 Apr 2013 , 26 Apr 2013

View Random Gene

Category			VWF (GIFTS: 73) von Willebrand factor
GIFtS Group

The GeneCards human gene database gene index: 1 3 5 6 A B C D E F G H I J K L M N O P Q R S T U V W X Y Z

The GeneCards Human Gene Database

Developed at the Crown Human Genome Center, Department of Molecular Genetics, the Weizmann Institute of Science

Hot genes Disease genes CFLAR gene at Home site.

hostname: 356980-web2.xennexinc.com index build: 100 solr: 1.4

Advanced Search

Export list of displayed genes

CFLAR Gene

CASP8 and FADD-like apoptosis regulator

Aliases
for CFLAR gene

Summaries
for CFLAR gene

Genomic Views
for CFLAR gene

Proteins
for CFLAR gene

Protein Domains /
Families
for CFLAR gene

Function
for CFLAR gene

Pathways & Interactions
for CFLAR gene

Drugs & Compounds
for CFLAR gene

Transcripts
for CFLAR gene

Expression
for CFLAR gene

Orthologs
for CFLAR gene

Paralogs
for CFLAR gene

Genomic Variants
for CFLAR gene

Disorders / Diseases
for CFLAR gene

Publications
for CFLAR gene

External Searches for CFLAR gene

Genome Databases showing CFLAR gene

Other Databases showing CFLAR gene

Specialized Databases showing CFLAR gene

Intellectual Property
for CFLAR gene

Products
for CFLAR gene

View Random Gene

CFLAR (Gene Symbol)
CASP8 And FADD-Like Apoptosis Regulator
CASH
CASP8AP1
CLARP
Casper
I-FLICE
MRIT
C-FLIP
FLIP
FLAME
Caspase Homolog
Caspase-Eight-Related Protein
Caspase-Like Apoptosis Regulatory Protein
Cellular FLICE-Like Inhibitory Protein
Inhibitor Of FLICE
FLAME-1
FADD-Like Antiapoptotic Molecule 1
MACH-Related Inducer Of Toxicity
FLAME1
C-FLIPL
C-FLIPR
C-FLIPS
Caspase-Related Inducer Of Apoptosis
FADD-Like Anti-Apoptotic Molecule
Usurpin Beta
Usurpin
CASPER

HERPES
Leukemia B-Cell
Kaposi Sarcoma
Infertility
Herpes Simplex
Erythroleukemia
aggressiveness
COLON CARCINOMA
Ischemia
Breast Cancer
NSCLC
Adenocarcinoma
Cancer
Colorectal Carcinoma
Cervical Intraepithelial Neoplasia
malignant ascites
ADENOCARCINOMA GASTRIC
Lymphoma
Pathological Processes
GASTRIC CARCINOMA
Shock
Ovarian Cancer
COLON ADENOCARCINOMA
Colorectal Cancer
Multiple Sclerosis
Inflammation
Burkitt Lymphoma
immunodeficiency
MYELOMA
ENDOMETRIAL CARCINOMA
Rheumatoid Arthritis
prostate cancer
Tumors
Metastasis
prostatic adenocarcinoma
Autoimmunity
Atresia
Necrosis
Sarcoma
Glioblastoma
virus infection
Malignant Glioma
Gastric Cancer
lymphoid neoplasm
Melanoma
Autoimmune Diseases
bladder cancer
Colon Cancer
CADASIL
Neurological Disorders
Leukemia Lymphocytic Chronic
Hyperplasia
Glioma
Carcinoma
Hodgkin Disease
INFARCT
Osteoarthritis
PROSTATE CARCINOMA
Leukemia
Thyroid Cancer
Alzheimers Disease
Osteosarcoma
HEPATOCELLULAR CARCINOMA
CERVICAL CARCINOMA
Carcinoma Renal Cell
Pancreatic Cancer
Cancer Lung
Alopecia Androgenetic
Lymphoma B-Cell
Skin Cancer
Ascites
Cholangiocarcinoma
Ewings sarcoma
Carcinoma Squamous Cell
BLADDER CARCINOMA
Lymphoma Non-Hodgkins
THYROID CARCINOMA
Myelodysplastic Syndromes
LEUKAEMIA LYMPHOCYTIC
Choriocarcinoma
Arthritis

Advanced Search

Export list of displayed genes

CFLAR Gene

CASP8 and FADD-like apoptosis regulator

Aliasesfor CFLAR gene

Summariesfor CFLAR gene

Genomic Viewsfor CFLAR gene

Proteinsfor CFLAR gene

Protein Domains /Familiesfor CFLAR gene

Functionfor CFLAR gene

Pathways & Interactionsfor CFLAR gene

Drugs & Compoundsfor CFLAR gene

Transcriptsfor CFLAR gene

Expression for CFLAR gene

Orthologsfor CFLAR gene

Paralogsfor CFLAR gene

Genomic Variantsfor CFLAR gene

Disorders / Diseasesfor CFLAR gene

Publicationsfor CFLAR gene

External Searches for CFLAR gene

Genome Databases showing CFLAR gene

Other Databases showing CFLAR gene

Specialized Databases showing CFLAR gene

Intellectual Propertyfor CFLAR gene

Productsfor CFLAR gene

View Random Gene

Aliases
for CFLAR gene

Summaries
for CFLAR gene

Genomic Views
for CFLAR gene

Proteins
for CFLAR gene

Protein Domains /
Families
for CFLAR gene

Function
for CFLAR gene

Pathways & Interactions
for CFLAR gene

Drugs & Compounds
for CFLAR gene

Transcripts
for CFLAR gene

Expression
for CFLAR gene

Orthologs
for CFLAR gene

Paralogs
for CFLAR gene

Genomic Variants
for CFLAR gene

Disorders / Diseases
for CFLAR gene

Publications
for CFLAR gene

Intellectual Property
for CFLAR gene

Products
for CFLAR gene