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Aliases for CFLAR Gene

Aliases for CFLAR Gene

  • CASP8 And FADD-Like Apoptosis Regulator 2 3
  • Casper 3 4 6
  • CASH 3 4 6
  • Caspase-Like Apoptosis Regulatory Protein 3 4
  • Cellular FLICE-Like Inhibitory Protein 3 4
  • FADD-Like Antiapoptotic Molecule 1 3 4
  • MACH-Related Inducer Of Toxicity 3 4
  • Caspase-Eight-Related Protein 3 4
  • Inhibitor Of FLICE 3 4
  • Caspase Homolog 3 4
  • CASP8AP1 3 4
  • FLAME-1 3 4
  • I-FLICE 3 4
  • FLAME1 3 6
  • C-FLIP 3 4
  • CLARP 3 4
  • FLIP 3 6
  • MRIT 3 4
  • Caspase-Related Inducer Of Apoptosis 3
  • Usurpin Beta 3
  • C-FLIPL 3
  • C-FLIPR 3
  • C-FLIPS 3
  • Usurpin 4
  • FLAME 3

External Ids for CFLAR Gene

Previous HGNC Symbols for CFLAR Gene

  • CASP8AP1

Previous GeneCards Identifiers for CFLAR Gene

  • GC02P200197
  • GC02P200705
  • GC02P201944
  • GC02P202183
  • GC02P201806
  • GC02P201689
  • GC02P201980
  • GC02P193832

Summaries for CFLAR Gene

Entrez Gene Summary for CFLAR Gene

  • The protein encoded by this gene is a regulator of apoptosis and is structurally similar to caspase-8. However, the encoded protein lacks caspase activity and appears to be itself cleaved into two peptides by caspase-8. Several transcript variants encoding different isoforms have been found for this gene, and partial evidence for several more variants exists. [provided by RefSeq, Feb 2011]

GeneCards Summary for CFLAR Gene

CFLAR (CASP8 And FADD-Like Apoptosis Regulator) is a Protein Coding gene. Diseases associated with CFLAR include cadasil and cervical intraepithelial neoplasia. Among its related pathways are ERK Signaling and Apoptotic Pathways in Synovial Fibroblasts. GO annotations related to this gene include protease binding and enzyme activator activity.

UniProtKB/Swiss-Prot for CFLAR Gene

  • Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.

Gene Wiki entry for CFLAR Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFLAR Gene

Genomics for CFLAR Gene

Regulatory Elements for CFLAR Gene

Transcription factor binding sites by QIAGEN in the CFLAR gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CFLAR Gene

Start:
201,116,104 bp from pter
End:
201,176,687 bp from pter
Size:
60,584 bases
Orientation:
Plus strand

Genomic View for CFLAR Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CFLAR Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFLAR Gene

Proteins for CFLAR Gene

  • Protein details for CFLAR Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15519-CFLAR_HUMAN
    Recommended name:
    CASP8 and FADD-like apoptosis regulator
    Protein Accession:
    O15519
    Secondary Accessions:
    • B4DJE0
    • B7Z9F9
    • O14673
    • O14674
    • O14675
    • O15137
    • O15138
    • O15356
    • O15510
    • O43618
    • O43619
    • O43620
    • O60458
    • O60459
    • Q53TS6
    • Q54AF1
    • Q96TE4
    • Q9UEW1

    Protein attributes for CFLAR Gene

    Size:
    480 amino acids
    Molecular mass:
    55344 Da
    Quaternary structure:
    • TNFRSF6 stimulation triggers recruitment to the death-inducing signaling complex (DISC) formed by TNFRSF6, FADD and caspase-8. A proteolytic fragment (p43) stays associated with the DISC. Also interacts with caspase-10, caspase-3, TRAF1, TRAF2 and Bcl-X(L) (in vitro). Interacts with HBV protein X.

    Three dimensional structures from OCA and Proteopedia for CFLAR Gene

neXtProt entry for CFLAR Gene

Proteomics data for CFLAR Gene at MOPED

Post-translational modifications for CFLAR Gene

  • Proteolytically processed; probably by caspase-8. Processing likely occurs at the DISC and generates subunit p43 and p12
  • Ubiquitination at Lys192
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CFLAR (CFLAR)

No data available for DME Specific Peptides for CFLAR Gene

Domains for CFLAR Gene

Gene Families for CFLAR Gene

HGNC:

Suggested Antigen Peptide Sequences for CFLAR Gene

Graphical View of Domain Structure for InterPro Entry

O15519

UniProtKB/Swiss-Prot:

CFLAR_HUMAN :
  • O15519
Domain:
  • The caspase domain lacks the active sites residues involved in catalysis
  • Contains 2 DED (death effector) domains.
Family:
  • Belongs to the peptidase C14A family.
genes like me logo Genes that share domains with CFLAR: view

Function for CFLAR Gene

Molecular function for CFLAR Gene

GENATLAS Biochemistry: caspase eight related,predominantly expressed in skeletal muscle,pancreas,heart,activated by Fas ligand,interacting with FADD and promoting apoptosis
UniProtKB/Swiss-Prot Function: Apoptosis regulator protein which may function as a crucial link between cell survival and cell death pathways in mammalian cells. Acts as an inhibitor of TNFRSF6 mediated apoptosis. A proteolytic fragment (p43) is likely retained in the death-inducing signaling complex (DISC) thereby blocking further recruitment and processing of caspase-8 at the complex. Full length and shorter isoforms have been shown either to induce apoptosis or to reduce TNFRSF-triggered apoptosis. Lacks enzymatic (caspase) activity.
UniProtKB/Swiss-Prot Induction: Repressed by IL2/interleukin-2 after TCR stimulation, during progression to the S phase of the cell cycle.

Gene Ontology (GO) - Molecular Function for CFLAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0002020 protease binding IPI 9208847
GO:0004197 cysteine-type endopeptidase activity --
GO:0005123 death receptor binding IEA --
GO:0005515 protein binding IPI 11741985
GO:0008047 enzyme activator activity IDA 9208847
genes like me logo Genes that share ontologies with CFLAR: view
genes like me logo Genes that share phenotypes with CFLAR: view

Animal Models for CFLAR Gene

MGI Knock Outs for CFLAR:

Animal Model Products

CRISPR Products

miRNA for CFLAR Gene

miRTarBase miRNAs that target CFLAR

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CFLAR Gene

Localization for CFLAR Gene

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CFLAR Gene COMPARTMENTS Subcellular localization image for CFLAR gene
Compartment Confidence
plasma membrane 5
cytosol 3
nucleus 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for CFLAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IDA 18073330
GO:0005829 cytosol TAS --
GO:0031264 death-inducing signaling complex IDA 21803845
GO:0031265 CD95 death-inducing signaling complex IEA --
GO:0045121 membrane raft IEA --
genes like me logo Genes that share ontologies with CFLAR: view

No data available for Subcellular locations from UniProtKB/Swiss-Prot for CFLAR Gene

Pathways for CFLAR Gene

genes like me logo Genes that share pathways with CFLAR: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CFLAR Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006508 proteolysis --
GO:0006915 apoptotic process TAS --
GO:0006919 activation of cysteine-type endopeptidase activity involved in apoptotic process IBA --
GO:0007519 skeletal muscle tissue development ISS --
GO:0010939 regulation of necrotic cell death TAS --
genes like me logo Genes that share ontologies with CFLAR: view

Compounds for CFLAR Gene

(68) Novoseek inferred chemical compound relationships for CFLAR Gene

Compound -log(P) Hits PubMed IDs
cycloheximide 63.4 29
suberoylanilide hydroxamic acid 62.4 7
mg 132 61.5 11
bortezomib 60.2 6
ly294002 56.3 9
genes like me logo Genes that share compounds with CFLAR: view

Transcripts for CFLAR Gene

Unigene Clusters for CFLAR Gene

CASP8 and FADD-like apoptosis regulator:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CFLAR

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CFLAR Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b ^ 4 ^ 5 ^ 6a · 6b · 6c · 6d · 6e · 6f ^ 7 ^ 8a · 8b · 8c · 8d · 8e ^ 9a · 9b · 9c · 9d ^ 10 ^ 11 ^
SP1: - - - - - - - - - - - -
SP2: - - - - - - - - -
SP3: - - - - -
SP4: - - - - -
SP5: - - - - -
SP6: - - - - - - - - - - - -
SP7: - - - - -
SP8: - -
SP9:
SP10: - - - - - - - - - - - -
SP11: - - - - -
SP12: - -
SP13:
SP14: - - -
SP15: - - - -
SP16: - -
SP17: - - - - - - - - - - - -
SP18: - - - - - - - - -
SP19: - - - - -
SP20: - - - - - - - - - - - - - -
SP21: - - - - - - - - -
SP22: - - -

ExUns: 12a · 12b · 12c ^ 13a · 13b · 13c ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b · 20c
SP1: - - - - - - -
SP2: - - - - - - -
SP3: - - - - - -
SP4: - - - - -
SP5: - - - - - - - - -
SP6: - - - - - - - - -
SP7: - - - - - - - - - -
SP8: - - - - - - -
SP9: - - - - - -
SP10: - -
SP11: - -
SP12: - - - - -
SP13: - - - - -
SP14:
SP15: -
SP16: - -
SP17:
SP18:
SP19:
SP20:
SP21:
SP22:

Relevant External Links for CFLAR Gene

GeneLoc Exon Structure for
CFLAR
ECgene alternative splicing isoforms for
CFLAR

Expression for CFLAR Gene

mRNA expression in normal human tissues for CFLAR Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CFLAR Gene

This gene is overexpressed in Whole Blood (7.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CFLAR Gene

SOURCE GeneReport for Unigene cluster for CFLAR Gene Hs.390736

mRNA Expression by UniProt/SwissProt for CFLAR Gene

O15519-CFLAR_HUMAN
Tissue specificity: Widely expressed. Higher expression in skeletal muscle, pancreas, heart, kidney, placenta, and peripheral blood leukocytes. Also detected in diverse cell lines. Isoform 8 is predominantly expressed in testis and skeletal muscle
genes like me logo Genes that share expressions with CFLAR: view

In Situ Assay Products

Orthologs for CFLAR Gene

This gene was present in the common ancestor of chordates.

Orthologs for CFLAR Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CFLAR 35
  • 99.79 (n)
  • 99.58 (a)
CFLAR 36
  • 100 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CFLAR 35
  • 82.25 (n)
  • 74.84 (a)
FLIP 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CFLAR 35
  • 83.47 (n)
  • 78.03 (a)
CFLAR 36
  • 77 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cflar 35
  • 75.72 (n)
  • 67.79 (a)
Cflar 16
Cflar 36
  • 67 (a)
OneToMany
Gm9845 36
  • 71 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CFLAR 36
  • 52 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CFLAR 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cflar 35
  • 76.3 (n)
  • 68.99 (a)
chicken
(Gallus gallus)
Aves CFLAR 35
  • 57.94 (n)
  • 51.06 (a)
CFLAR 36
  • 47 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CFLAR 36
  • 44 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cflar 35
  • 49.96 (n)
  • 42.02 (a)
zebrafish
(Danio rerio)
Actinopterygii -- 35
cflara 35
  • 47.58 (n)
  • 36.25 (a)
cflara 36
  • 34 (a)
OneToMany
cflarb 36
  • 30 (a)
OneToMany
Species with no ortholog for CFLAR:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFLAR Gene

ENSEMBL:
Gene Tree for CFLAR (if available)
TreeFam:
Gene Tree for CFLAR (if available)

Paralogs for CFLAR Gene

genes like me logo Genes that share paralogs with CFLAR: view

No data available for Paralogs for CFLAR Gene

Variants for CFLAR Gene

Sequence variations from dbSNP and Humsavar for CFLAR Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1594 -- 201,160,898(-) AGGGA(C/T)GGTGA reference, synonymous-codon
rs1060975 -- 201,164,004(+) CTCAC(A/G)CCTGT utr-variant-3-prime
rs1061061 -- 201,163,925(+) TATGT(C/T)TGGCT reference, synonymous-codon, utr-variant-3-prime
rs1071678 -- 201,171,569(+) TGATA(C/G)GTTGA utr-variant-3-prime
rs1134476 -- 201,171,630(+) acatc(C/T)tgcac utr-variant-3-prime

Relevant External Links for CFLAR Gene

HapMap Linkage Disequilibrium report
CFLAR
Human Gene Mutation Database (HGMD)
CFLAR

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CFLAR Gene

Disorders for CFLAR Gene

(81) Novoseek inferred disease relationships for CFLAR Gene

Disease -log(P) Hits PubMed IDs
necrosis 77 39
tumors 68.1 127
cancer 59.3 62
colon cancer 46.9 20
malignant glioma 46.4 5

Relevant External Links for CFLAR

Genetic Association Database (GAD)
CFLAR
Human Genome Epidemiology (HuGE) Navigator
CFLAR
genes like me logo Genes that share disorders with CFLAR: view

No data available for UniProtKB/Swiss-Prot for CFLAR Gene

Publications for CFLAR Gene

  1. Inhibition of death receptor signals by cellular FLIP. (PMID: 9217161) Irmler M. … Tschopp J. (Nature 1997) 2 3 4 23
  2. CLARP, a death effector domain-containing protein interacts with caspase-8 and regulates apoptosis. (PMID: 9380701) Inohara N. … Nunez G. (Proc. Natl. Acad. Sci. U.S.A. 1997) 3 4 23
  3. The role of c-FLIP in modulation of CD95-induced apoptosis. (PMID: 9880531) Scaffidi C. … Peter M.E. (J. Biol. Chem. 1999) 3 4 23
  4. Cell death attenuation by 'Usurpin', a mammalian DED-caspase homologue that precludes caspase-8 recruitment and activation by the CD-95 (Fas, APO-1) receptor complex. (PMID: 10200473) Rasper D.M. … Nicholson D.W. (Cell Death Differ. 1998) 3 4 23
  5. Cell cycle-dependent regulation of FLIP levels and susceptibility to Fas-mediated apoptosis. (PMID: 10227994) Algeciras-Schimnich A. … Paya C.V. (J. Immunol. 1999) 3 4 23

Products for CFLAR Gene

  • Addgene plasmids for CFLAR

Sources for CFLAR Gene

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