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Aliases for CFL1 Gene

Aliases for CFL1 Gene

  • Cofilin 1 (Non-Muscle) 2 3
  • Cofilin, Non-Muscle Isoform 3 4
  • 18 KDa Phosphoprotein 3 4
  • P18 3 4
  • CFL 3 4
  • Epididymis Secretory Protein Li 15 3
  • Cofilin-1 3
  • HEL-S-15 3

External Ids for CFL1 Gene

Previous HGNC Symbols for CFL1 Gene

  • CFL

Previous GeneCards Identifiers for CFL1 Gene

  • GC11M068156
  • GC11M067303
  • GC11M065872
  • GC11M065397
  • GC11M065378
  • GC11M065622
  • GC11M061948

Summaries for CFL1 Gene

Entrez Gene Summary for CFL1 Gene

  • The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

GeneCards Summary for CFL1 Gene

CFL1 (Cofilin 1 (Non-Muscle)) is a Protein Coding gene. Diseases associated with CFL1 include corticobasal degeneration and smith-lemli-opitz syndrome. Among its related pathways are Regulation of actin cytoskeleton and Regulation of actin cytoskeleton. GO annotations related to this gene include actin binding. An important paralog of this gene is DSTN.

UniProtKB/Swiss-Prot for CFL1 Gene

  • Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation.

Gene Wiki entry for CFL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFL1 Gene

Genomics for CFL1 Gene

Regulatory Elements for CFL1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CFL1 Gene

Start:
65,823,022 bp from pter
End:
65,862,026 bp from pter
Size:
39,005 bases
Orientation:
Minus strand

Genomic View for CFL1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CFL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFL1 Gene

Proteins for CFL1 Gene

  • Protein details for CFL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23528-COF1_HUMAN
    Recommended name:
    Cofilin-1
    Protein Accession:
    P23528
    Secondary Accessions:
    • B3KUQ1
    • Q53Y87
    • Q9UCA2

    Protein attributes for CFL1 Gene

    Size:
    166 amino acids
    Molecular mass:
    18502 Da
    Quaternary structure:
    • Can bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is a major component of intranuclear and cytoplasmic actin rods

    Three dimensional structures from OCA and Proteopedia for CFL1 Gene

neXtProt entry for CFL1 Gene

Proteomics data for CFL1 Gene at MOPED

Post-translational modifications for CFL1 Gene

  • Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal (By similarity). Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2.
  • Ubiquitination at Lys13, Lys19, Lys73, Lys92, Lys112, Lys114, Lys121, Lys132, Lys144, and Lys164
  • Modification sites at PhosphoSitePlus

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CFL1 (Cofilin-1)

No data available for DME Specific Peptides for CFL1 Gene

Domains for CFL1 Gene

Suggested Antigen Peptide Sequences for CFL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23528

UniProtKB/Swiss-Prot:

COF1_HUMAN :
  • P23528
Domain:
  • Contains 1 ADF-H domain.
Family:
  • Belongs to the actin-binding proteins ADF family.
genes like me logo Genes that share domains with CFL1: view

No data available for Gene Families for CFL1 Gene

Function for CFL1 Gene

Molecular function for CFL1 Gene

GENATLAS Biochemistry:
cofilin 1,actin-binding protein,non-muscle type,depolymerisation factor of F-actin to G-actin
UniProtKB/Swiss-Prot Function:
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).

Gene Ontology (GO) - Molecular Function for CFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003779 actin binding IEA --
GO:0005515 protein binding IPI 12361576
genes like me logo Genes that share ontologies with CFL1: view
genes like me logo Genes that share phenotypes with CFL1: view

Animal Models for CFL1 Gene

MGI Knock Outs for CFL1:

Animal Model Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CFL1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Transcription Factor Targeting and HOMER Transcription for CFL1 Gene

Localization for CFL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFL1 Gene

Nucleus matrix. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CFL1 Gene COMPARTMENTS Subcellular localization image for CFL1 gene
Compartment Confidence
cytoskeleton 5
nucleus 5
plasma membrane 5
cytosol 3
mitochondrion 2

Gene Ontology (GO) - Cellular Components for CFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005622 intracellular --
GO:0005634 nucleus TAS 16130169
GO:0005737 cytoplasm TAS 16130169
GO:0005886 plasma membrane --
genes like me logo Genes that share ontologies with CFL1: view

Pathways for CFL1 Gene

genes like me logo Genes that share pathways with CFL1: view

PCR Array Products

Gene Ontology (GO) - Biological Process for CFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000281 mitotic cytokinesis IEA --
GO:0001755 neural crest cell migration IEA --
GO:0001842 neural fold formation IEA --
GO:0002576 platelet degranulation TAS --
GO:0006468 protein phosphorylation IEA --
genes like me logo Genes that share ontologies with CFL1: view

Compounds for CFL1 Gene

(1) Drugbank Compounds for CFL1 Gene

Compound Synonyms Cas Number Type Actions PubMed IDs
Lauryl Dimethylamine-N-Oxide
target

(4) Novoseek inferred chemical compound relationships for CFL1 Gene

Compound -log(P) Hits PubMed IDs
isocitrate 54.3 1
superoxide 14.6 3
atp 0 1
calcium 0 1
genes like me logo Genes that share compounds with CFL1: view

Transcripts for CFL1 Gene

Unigene Clusters for CFL1 Gene

Cofilin 1 (non-muscle):
Representative Sequences:

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CFL1

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CFL1 Gene

No ASD Table

Relevant External Links for CFL1 Gene

GeneLoc Exon Structure for
CFL1
ECgene alternative splicing isoforms for
CFL1

Expression for CFL1 Gene

mRNA expression in normal human tissues for CFL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CFL1 Gene

This gene is overexpressed in Whole Blood (5.4).

Protein differential expression in normal tissues for CFL1 Gene

This gene is overexpressed in NK cells (6.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CFL1 Gene

SOURCE GeneReport for Unigene cluster for CFL1 Gene Hs.170622

mRNA Expression by UniProt/SwissProt for CFL1 Gene

P23528-COF1_HUMAN
Tissue specificity: Widely distributed in various tissues
genes like me logo Genes that share expressions with CFL1: view

Expression partners for CFL1 Gene

In Situ Assay Products

Orthologs for CFL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CFL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CFL1 35
  • 94.58 (n)
  • 99.4 (a)
CFL1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CFL1 35
  • 93.37 (n)
  • 100 (a)
CFL1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cfl1 35
  • 93.37 (n)
  • 98.8 (a)
Cfl1 16
Cfl1 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CFL1 35
  • 99.8 (n)
  • 100 (a)
CFL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cfl1 35
  • 91.97 (n)
  • 99.4 (a)
lizard
(Anolis carolinensis)
Reptilia CFL1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cfl1 35
  • 71.08 (n)
  • 78.31 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.28198 35
cfl1 36
  • 75 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COF1 36
  • 41 (a)
OneToMany
COF1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
ManyToMany
CSA.4636 36
  • 28 (a)
ManyToMany
Species with no ortholog for CFL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFL1 Gene

ENSEMBL:
Gene Tree for CFL1 (if available)
TreeFam:
Gene Tree for CFL1 (if available)

Paralogs for CFL1 Gene

Paralogs for CFL1 Gene

Selected SIMAP similar genes for CFL1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CFL1: view

Variants for CFL1 Gene

Sequence variations from dbSNP and Humsavar for CFL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type MAF
rs4621 -- 65,856,048(+) TAGGG(A/G)TCGTC reference, synonymous-codon
rs652021 -- 65,855,876(+) CCACA(A/G)AAGTT intron-variant
rs665306 -- 65,856,554(+) ACTCA(C/T)TTGCT intron-variant
rs667555 -- 65,857,091(-) ATTGG(G/T)GAGGG intron-variant
rs669300 -- 65,857,019(+) GCAGA(A/G)GAAGC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CFL1 Gene

Variant ID Type Subtype PubMed ID
nsv897736 CNV Loss 21882294
dgv393e1 CNV Complex 17122850
dgv1185n71 CNV Loss 21882294
nsv897763 CNV Loss 21882294
nsv897764 CNV Loss 21882294
nsv897766 CNV Loss 21882294

Relevant External Links for CFL1 Gene

HapMap Linkage Disequilibrium report
CFL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CFL1 Gene

Disorders for CFL1 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CFL1 Gene in MalaCards »

(2) Diseases for CFL1 Gene including...

(2) Novoseek inferred disease relationships for CFL1 Gene

Disease -log(P) Hits PubMed IDs
shock 0 1
tumors 0 2

Relevant External Links for CFL1

Genetic Association Database (GAD)
CFL1
Human Genome Epidemiology (HuGE) Navigator
CFL1
genes like me logo Genes that share disorders with CFL1: view

No data available for OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES and Genatlas for CFL1 Gene

Publications for CFL1 Gene

  1. Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14. (PMID: 8800436) Gillett G.T. … Povey S. (Ann. Hum. Genet. 1996) 2 3 4 23
  2. Association between CFL1 gene polymorphisms and spina bifida risk in a California population. (PMID: 17352815) Zhu H. … Finnell R.H. (BMC Med. Genet. 2007) 3 23 48
  3. Dephosphorylation of cofilin in stimulated platelets: roles for a GTP-binding protein and Ca2+. (PMID: 8037689) Davidson M.M. … Haslam R.J. (Biochem. J. 1994) 3 4 23
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  5. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PMID: 16548883) Leong W.F. … Chow V.T. (Cell. Microbiol. 2006) 3 4

Products for CFL1 Gene

  • Addgene plasmids for CFL1

Sources for CFL1 Gene

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