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CFL1 Gene

protein-coding   GIFtS: 69
GCID: GC11M065622

Cofilin 1 (Non-Muscle)


(Previous symbol: CFL)
  See CFL1-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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This gene clusters with an RNA gene
Subcategory (RNA class): antisense

Quality score for the ORGUL clustered with this gene is 3

Aliases
Cofilin 1 (Non-Muscle)1 2     p182 3
CFL1 2 3     HEL-S-152
Cofilin, Non-Muscle Isoform2 3     cofilin-12
18 KDa Phosphoprotein2 3     Epididymis Secretory Protein Li 152

External Ids:    HGNC: 18741   Entrez Gene: 10722   Ensembl: ENSG000001727577   OMIM: 6014425   UniProtKB: P235283   
ORGUL members:         

Export aliases for CFL1 gene to outside databases

Previous GC identifers: GC11M068156 GC11M067303 GC11M065872 GC11M065397 GC11M065378 GC11M061948


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CFL1 Gene:
The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner.
Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin
cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes
filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved
in the translocation of actin-cofilin complex from cytoplasm to nucleus.(supplied by OMIM, Apr 2004)

GeneCards Summary for CFL1 Gene:
CFL1 (cofilin 1 (non-muscle)) is a protein-coding gene. Diseases associated with CFL1 include corticobasal degeneration. GO annotations related to this gene include actin binding. An important paralog of this gene is CFL2.

UniProtKB/Swiss-Prot: COF1_HUMAN, P23528
Function: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton
dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of
cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor
ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation

Gene Wiki entry for CFL1 (Cofilin 1) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000011.9  NC_018922.2  NT_167190.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CFL1 gene promoter:
         p53   AP-1   Pax-6   ATF-2   Lmo2   E47   GATA-2   COMP1   c-Jun   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CFL1 promoter sequence
   Search Chromatin IP Primers for CFL1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CFL1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13   Ensembl cytogenetic band:  11q13.1   HGNC cytogenetic band: 11q13.1

CFL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CFL1 gene location

GeneLoc information about chromosome 11         GeneLoc Exon Structure

GeneLoc location for GC11M065622:  view genomic region     (about GC identifiers)

Start:
65,590,493 bp from pter      End:
65,629,497 bp from pter
Size:
39,005 bases      Orientation:
minus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: COF1_HUMAN, P23528 (See protein sequence)
Recommended Name: Cofilin-1  
Size: 166 amino acids; 18502 Da
Subunit: Can bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is a major component of intranuclear and
cytoplasmic actin rods
4 PDB 3D structures from and Proteopedia for CFL1:
1Q8G (3D)        1Q8X (3D)        3J0S (3D)        4BEX (3D)    
Secondary accessions: B3KUQ1 Q53Y87 Q9UCA2

Explore the universe of human proteins at neXtProt for CFL1: NX_P23528

Explore proteomics data for CFL1 at MOPED

Post-translational modifications: 

  • Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (By similarity).
    Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The
    phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal (By similarity).
    Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor
    ACKR21
  • Ubiquitination2 at Lys13, Lys19, Lys73, Lys92, Lys112, Lys114, Lys121, Lys132, Lys144, Lys164
  • Modification sites at PhosphoSitePlus

  • See CFL1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_005498.1  
    ENSEMBL proteins: 
     ENSP00000432660   ENSP00000432155   ENSP00000433910   ENSP00000432226   ENSP00000431696  
     ENSP00000433131   ENSP00000436431   ENSP00000436899   ENSP00000433308   ENSP00000432153  
     ENSP00000309629  
    Reactome Protein details: P23528

    CFL1 Human Recombinant Protein Products:

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    Novus Biologicals CFL1 Proteins
    Novus Biologicals CFL1 Lysate
    Sino Biological Recombinant Protein for CFL1
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    ProSpec Recombinant Protein for CFL1
    Cloud-Clone Corp. Proteins for CFL1

     
    Search eBioscience for Proteins for CFL1 

    CFL1 Antibody Products:

    EMD Millipore Mono- and Polyclonal Antibodies for the study of CFL1
    Browse R&D Systems for Antibodies
    Cell Signaling Technology (CST) Antibodies for CFL1  (cofilin 1)
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    OriGene Custom Antibody Services for CFL1
    Novus Biologicals CFL1 Antibodies
    Abcam antibodies for CFL1 (P23528, Q15906)
    Cloud-Clone Corp. Antibodies for CFL1
    ThermoFisher Antibody for CFL1
    LSBio Antibodies in human, mouse, rat for CFL1

    CFL1 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CFL1
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CFL1
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CFL1
    Cloud-Clone Corp. CLIAs for CFL1
    Search eBioscience for ELISAs for CFL1 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    2 InterPro protein domains:
     IPR002108 Actin-bd_cofilin/tropomyosin
     IPR017904 ADF/Cofilin/Destrin

    Graphical View of Domain Structure for InterPro Entry P23528

    ProtoNet protein and cluster: P23528

    1 Blocks protein domain: IPB002108 Actin-binding

    UniProtKB/Swiss-Prot: COF1_HUMAN, P23528
    Similarity: Belongs to the actin-binding proteins ADF family
    Similarity: Contains 1 ADF-H domain


    Find genes that share domains with CFL1           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: COF1_HUMAN, P23528
    Function: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton
    dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of
    cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor
    ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation
    Induction: Up-regulated in response to enterovirus 71 (EV71) infection (at protein level)

         Genatlas biochemistry entry for CFL1:
    cofilin 1,actin-binding protein,non-muscle type,depolymerisation factor of F-actin to G-actin

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003779actin binding IEA--
    GO:0005515protein binding IPI12361576
         
    Find genes that share ontologies with CFL1           About GenesLikeMe


    Phenotypes:
         8 GenomeRNAi human phenotypes for CFL1:
     Abundance of large cells with   Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella enterica  
     Increased Salmonella enterica   Increased Salmonella enterica   Increased Salmonella-containin  Synthetic lethal with Ras 

         13 MGI mutant phenotypes (inferred from 5 alleles(MGI details for Cfl1):
     behavior/neurological  cardiovascular system  cellular  embryogenesis  growth/size/body 
     homeostasis/metabolism  integument  mortality/aging  nervous system  no phenotypic analysis 
     normal  renal/urinary system  vision/eye 

    Find genes that share phenotypes with CFL1           About GenesLikeMe

    Animal Models:
         MGI mouse knock-out Cfl1tm1.2Wit for CFL1

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CFL1
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CFL1

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CFL1
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CFL1

    miRNA
    Products:
        
    miRTarBase miRNAs that target CFL1:
    hsa-mir-484 (MIRT041842), hsa-mir-193b-3p (MIRT041581), hsa-mir-877-3p (MIRT037082), hsa-mir-324-5p (MIRT043254), hsa-mir-1301-3p (MIRT036064), hsa-mir-34a-5p (MIRT025334)

    Block miRNA regulation of human, mouse, rat CFL1 using miScript Target Protectors
    Selected qRT-PCR Assays for microRNAs that regulate CFL1 (see all 21):
    hsa-miR-3128 hsa-miR-596 hsa-miR-185* hsa-miR-1271 hsa-miR-486-3p hsa-miR-3916 hsa-miR-3125 hsa-miR-342-5p
    SwitchGear 3'UTR luciferase reporter plasmidCFL1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CFL1
    Predesigned siRNA for gene silencing in human, mouse, rat CFL1

    Gene Editing
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    Clone
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    OriGene clones in human, mouse for CFL1 (see all 8)
    OriGene ORF clones in mouse, rat for CFL1
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    GenScript: all cDNA clones in your preferred vector: CFL1 (NM_005507)
    Sino Biological Human cDNA Clone for CFL1
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CFL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CFL1
    Addgene plasmids for CFL1 

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CFL1
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFL1


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    COF1_HUMAN, P23528: Nucleus matrix. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral
    membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein;
    Cytoplasmic side. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at
    the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to
    heat shock or 10% dimethyl sulfoxide
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    nucleus5
    plasma membrane5
    cytosol3
    mitochondrion2

    Gene Ontology (GO): Selected cellular component terms (see all 12):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space IDA--
    GO:0005622intracellular ----
    GO:0005634nucleus TAS16130169
    GO:0005737cytoplasm TAS16130169
    GO:0015629actin cytoskeleton ----

    Find genes that share ontologies with CFL1           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CFL1 About   (see all 31)  
    See pathways by source

    SuperPathContained pathways About
    1Development Slit Robo signaling
    Development Slit Robo signaling0.92
    Neurophysiological process Receptor mediated axon growth repulsion0.41
    Cytoskeleton remodeling Slit Robo signaling0.92
    2Regulation of actin cytoskeleton
    Regulation of actin cytoskeleton0.57
    Regulation of Actin Cytoskeleton0.57
    3Immune response CCR3 signaling in eosinophils
    Inhibitory action of Lipoxins on neutrophil migration0.51
    Immune response CCR3 signaling in eosinophils0.51
    4Cell adhesion Integrin mediated cell adhesion and migration
    Cell adhesion Integrin mediated cell adhesion and migration0.49
    Development MAG dependent inhibition of neurite outgrowth0.46
    Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases0.49
    Cytoskeleton remodeling Fibronectin binding integrins in cell motility0.32
    5Actin Nucleation by ARP-WASP Complex
    Actin Nucleation and Branching0.66
    RhoA Pathway0.35
    CDC42 Pathway0.41


    Find genes that share SuperPaths with CFL1           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    Selected Downloadable PowerPoint Slides of GeneGlobe Pathway Central Maps for CFL1 (see all 15)
        RhoA Pathway
    Sertoli-Sertoli Cell Junction Dynamics
    Actin-Based Motility by Rho Family GTPases
    Guidance Cues and Growth Cone Motility
    Internalin Pathway

    1 Cell Signaling Technology (CST) Pathway for CFL1
        Cytoskeletal Signaling

    Selected GeneGo (Thomson Reuters) Pathways for CFL1 (see all 10)
        Cytoskeleton remodeling CDC42 in cellular processes
    Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
    Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
    Neurophysiological process Receptor-mediated axon growth repulsion
    Development Slit-Robo signaling

    Selected BioSystems Pathways for CFL1 (see all 7)
        G13 Signaling Pathway
    BDNF signaling pathway
    Regulation of Actin Cytoskeleton
    CDC42 signaling events
    CXCR4-mediated signaling events


    3 Reactome Pathways for CFL1
        Platelet degranulation
    Regulation of actin dynamics for phagocytic cup formation
    Sema3A PAK dependent Axon repulsion


    4 Kegg Pathways  (Kegg details for CFL1):
        Axon guidance
    Fc gamma R-mediated phagocytosis
    Regulation of actin cytoskeleton
    Pertussis

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CFL1: 
              Cytoskeleton Regulators in human mouse rat
              Apoptosis 384HT in human mouse rat
              Cell Motility in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CFL1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CFL1 (P235281, 2, 3 ENSP000003096294) via UniProtKB, MINT, STRING, and/or I2D (see all 289)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    HIST1H4AP628053I2D: score=1 
    HIST1H4BP628053I2D: score=1 
    HIST1H4CP628053I2D: score=1 
    HIST1H4DP628053I2D: score=1 
    HIST1H4EP628053I2D: score=1 
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 25):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000910cytokinesis ----
    GO:0001755neural crest cell migration IEA--
    GO:0001842neural fold formation IEA--
    GO:0002576platelet degranulation TAS--
    GO:0006468protein phosphorylation IEA--

    Find genes that share ontologies with CFL1           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CFL1 (COF1)

    1 DrugBank Compound for CFL1    About this table
    CompoundSynonyms CAS #TypeActionsPubMed Ids
    Lauryl Dimethylamine-N-Oxide-- --target--10592235

    4 Novoseek inferred chemical compound relationships for CFL1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    isocitrate 54.3 1 17269733 (1)
    superoxide 14.6 3 19288589 (1), 17320137 (1), 18335753 (1)
    atp 0 1 16222722 (1)
    calcium 0 3 8037689 (1)



    Find genes that share compounds with CFL1           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CFL1 gene: 
    NM_005507.2  

    Unigene Cluster for CFL1:

    Cofilin 1 (non-muscle)
    Hs.170622  [show with all ESTs]
    Unigene Representative Sequence: BM462286
    15 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000530157 ENST00000527752 ENST00000525710 ENST00000525451(uc001ofs.3 uc001oft.3)
    ENST00000530945 ENST00000527344 ENST00000531407 ENST00000524553 ENST00000534769
    ENST00000531413 ENST00000532134 ENST00000530413 ENST00000534784 ENST00000526975
    ENST00000308162
    miRNA
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    Selected qRT-PCR Assays for microRNAs that regulate CFL1 (see all 21):
    hsa-miR-3128 hsa-miR-596 hsa-miR-185* hsa-miR-1271 hsa-miR-486-3p hsa-miR-3916 hsa-miR-3125 hsa-miR-342-5p
    SwitchGear 3'UTR luciferase reporter plasmidCFL1 3' UTR sequence
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    GenScript: all cDNA clones in your preferred vector: CFL1 (NM_005507)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CFL1
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CFL1
    Addgene plasmids for CFL1 
    Primer
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    OriGene qPCR primer pairs and template standards for CFL1
    OriGene qSTAR qPCR primer pairs in human, mouse for CFL1
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CFL1
      QuantiTect SYBR Green Assays in human, mouse, rat CFL1
      QuantiFast Probe-based Assays in human, mouse, rat CFL1

    Additional mRNA sequence: 

    AK097690.1 AK303614.1 BC011005.2 BC012265.1 BC012318.1 BC018256.2 BC024975.1 BT006846.1 
    D00682.1 HM370399.1 U21909.1 X95404.1 

    Selected DOTS entries (see all 70):

    DT.100034533  DT.95300732  DT.92469951  DT.95257655  DT.95257774  DT.95257650  DT.100710996  DT.453374 
    DT.100710974  DT.100710983  DT.120689975  DT.95257692  DT.120690158  DT.120690019  DT.95257673  DT.100711015 
    DT.120690035  DT.92469974  DT.100711007  DT.100710990  DT.95314585  DT.92469996  DT.100711017  DT.120690037 

    Selected AceView cDNA sequences (see all 2886):

    BM558543 CB147501 BM912498 CA450575 AA573359 AW162123 BQ941670 AI633498 
    BU629194 BF871978 BQ001597 BI918372 BI091336 BM564931 N75474 BM810953 
    AL545946 CR625803 CR622701 AW172856 AA640933 BM761307 BQ686773 U21909 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

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    CFL1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GAAGCAGGAC
    CFL1 Expression
    About this image


    CFL1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 20) fully expand
     
     Kidney (Urinary System)
             Ureteric Bud Cells Ureteric Bud
     
     Brain (Nervous System)
             Cerebral Cortex
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Heart (Cardiovascular System)
             Atrioventricular Node Cells Atrioventricular Node
     
     Colon (Gastrointestinal Tract)
    CFL1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CFL1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.170622

    UniProtKB/Swiss-Prot: COF1_HUMAN, P23528
    Tissue specificity: Widely distributed in various tissues

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CFL1: 
              Cytoskeleton Regulators in human mouse rat
              Apoptosis 384HT in human mouse rat
              Cell Motility in human mouse rat

    Primer
    Products:
    OriGene qPCR primer pairs and template standards for CFL1
    OriGene qSTAR qPCR primer pairs in human, mouse for CFL1
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of animals and fungi.

    Orthologs for CFL1 gene from Selected species (see all 12)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cfl11 , 5 cofilin 1, non-muscle1, 5 93.37(n)1
    98.8(a)1
      19 (4.34 cM)5
    126311  NM_007687.51  NP_031713.11 
     54904855 
    lizard
    (Anolis carolinensis)
    Reptilia CFL16
    cofilin 1 (non-muscle)
    69(a)
    1 ↔ 1
    AAWZ02038494(1421-3733)
    African clawed frog
    (Xenopus laevis)
    Amphibia BC044691.12   -- 75.98(n)    BC044691.1 
    zebrafish
    (Danio rerio)
    Actinopterygii Dr.281982 Danio rerio clone RZ151A2B11 muscle cofilin 2 (CFL2) more 79.21(n)    AY398324.1 
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes COF1(YLL050C)4 Cofilin, promotes actin filament depolarization in more   --   12(40414-39804) 850676  NP_013050.1 


    ENSEMBL Gene Tree for CFL1 (if available)
    TreeFam Gene Tree for CFL1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CFL1 gene
    CFL22  DSTN2  
    2 SIMAP similar genes for CFL1 using alignment to 7 protein entries:     COF1_HUMAN (see all proteins):
    CFL2    DSTN

    Find genes that share paralogs with CFL1           About GenesLikeMe


    Selected Pseudogenes.org Pseudogenes for CFL1 (see all 11)
    PGOHUM00000238876 PGOHUM00000257962 PGOHUM00000257995 PGOHUM00000243889 PGOHUM00000244022


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CFL1 (see all 122)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 11 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1421177131,2
    C--65621860(+) TGACCC/TTCATA 1 -- ds50010--------
    rs1178711191,2
    C,F--65621888(+) CAGGGA/GAGACA 1 -- ds50011Minor allele frequency- G:0.04EA 120
    rs1504608221,2
    --65621927(+) TCTGAC/GTTGCC 1 -- ds50010--------
    rs1383054761,2
    --65621932(+) CTTGCC/GTATCA 1 -- ds50010--------
    rs1887928041,2
    --65621966(+) ACAGAA/GTATCA 1 -- ds50010--------
    rs1173702561,2
    F--65621994(+) ATCCAG/AGCAAG 1 -- ds50011Minor allele frequency- A:0.01EA 120
    rs6353751,2
    C,F,A,H--65621995(+) TCCAGG/ACAAGG 1 -- ds500124Minor allele frequency- A:0.41EA NA MN NS WA 2744
    rs1818068851,2
    --65621998(+) AGGCAA/GGGCTA 1 -- ds50010--------
    rs1496415091,2
    --65622026(+) GCATAA/CATCAC 1 -- ds50010--------
    rs1863070391,2
    --65622035(+) ACTTCC/TGCTGG 1 -- ds50010--------

    HapMap Linkage Disequilibrium report for CFL1 (65590493 - 65629497 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 6 variations for CFL1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv897766CNV Loss21882294
    nsv897764CNV Loss21882294
    nsv897763CNV Loss21882294
    dgv1185n71CNV Loss21882294
    nsv897736CNV Loss21882294
    dgv393e1CNV Complex17122850

    Site Specific Mutation Identification with PCR Assays
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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 601442    OMIM disorders: --

    1 disease for CFL1:    
    About MalaCards
    corticobasal degeneration


    Find genes that share disorders with CFL1           About GenesLikeMe

    2 Novoseek inferred disease relationships for CFL1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    shock 0 1 12922171 (1)
    tumors 0 2 18401453 (1), 2278968 (1)

    Genetic Association Database (GAD): CFL1
    Human Genome Epidemiology (HuGE) Navigator: CFL1 (1 document)

    Export disorders for CFL1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CFL1 gene, integrated from 10 sources (see all 247):
    (articles sorted by number of sources associating them with CFL1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14. (PubMed id 8800436)1, 2, 3, 9 Gillett G.T.... Povey S. (Ann. Hum. Genet. 1996)
    2. Association between CFL1 gene polymorphisms and spina bifida risk in a California population. (PubMed id 17352815)1, 4, 9 Zhu H....Finnell R.H. (BMC Med. Genet. 2007)
    3. Dephosphorylation of cofilin in stimulated platelets: roles for a GTP-binding protein and Ca2+. (PubMed id 8037689)1, 2, 9 Davidson M.M. and Haslam R.J. (Biochem. J. 1994)
    4. Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PubMed id 16548883)1, 2 Leong W.F. and Chow V.T. (Cell. Microbiol. 2006)
    5. Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)1, 2 Olsen J.V....Mann M. (Cell 2006)
    6. Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)1, 2 Rush J.... Comb M.J. (Nat. Biotechnol. 2005)
    7. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    8. Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor. (PubMed id 14627701)1, 2 Pope B.J.... Ball L.J. (J. Biol. Chem. 2004)
    9. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    10. Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)1, 2 Gevaert K.... Vandekerckhove J. (Nat. Biotechnol. 2003)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1072 HGNC: 1874 AceView: CFL1andEFEMP2 Ensembl:ENSG00000172757 euGenes: HUgn1072
    ECgene: CFL1 Kegg: 1072 H-InvDB: CFL1

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CFL1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CFL1 Genetics and Cytogenetics in Oncology and Haematology
    Wikipedia http://en.wikipedia.org/wiki/Cofilin

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CFL1 gene:
    Search GeneIP for patents involving CFL1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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