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Aliases for CFL1 Gene

Aliases for CFL1 Gene

  • Cofilin 1 2 3 5
  • Cofilin, Non-Muscle Isoform 3 4
  • Cofilin 1 (Non-Muscle) 2 3
  • 18 KDa Phosphoprotein 3 4
  • P18 3 4
  • CFL 3 4
  • Epididymis Secretory Protein Li 15 3
  • Cofilin-1 3
  • HEL-S-15 3
  • Cofilin 3

External Ids for CFL1 Gene

Previous HGNC Symbols for CFL1 Gene

  • CFL

Previous GeneCards Identifiers for CFL1 Gene

  • GC11M068156
  • GC11M067303
  • GC11M065872
  • GC11M065397
  • GC11M065378
  • GC11M065622
  • GC11M061948

Summaries for CFL1 Gene

Entrez Gene Summary for CFL1 Gene

  • The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

GeneCards Summary for CFL1 Gene

CFL1 (Cofilin 1) is a Protein Coding gene. Diseases associated with CFL1 include Corticobasal Degeneration. Among its related pathways are CXCR4-mediated signaling events and EPHA forward signaling. GO annotations related to this gene include actin binding. An important paralog of this gene is CFL2.

UniProtKB/Swiss-Prot for CFL1 Gene

  • Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity).

Gene Wiki entry for CFL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFL1 Gene

Genomics for CFL1 Gene

Regulatory Elements for CFL1 Gene

Enhancers for CFL1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH11F065886 1.6 FANTOM5 ENCODE 15.2 -33.4 -33433 18.4 CREB3L1 ZFP64 FEZF1 DMAP1 YY1 SLC30A9 ZNF143 ZNF263 SP3 NFYC SNX32 CTSW MRPL11 EIF1AD NEAT1 MUS81 ENSG00000258297 KAT5 FAU POLA2
GH11F065927 1.5 FANTOM5 Ensembl ENCODE 11.3 -66.2 -66201 2.5 HDGF NFRKB THAP11 CBFB SP1 NFIL3 ZNF589 SMARCA4 RCOR2 IKZF1 EIF1AD CST6 FIBP CCDC85B CTSW SART1 FOSL1 CFL1 MUS81 BANF1
GH11F065819 1.2 Ensembl ENCODE 11.9 +39.8 39798 5.4 HDGF MLX ARID4B DMAP1 YY1 GLIS2 ZNF143 SP3 JUNB REST CTSW MUS81 CFL1 OVOL1-AS1 OVOL1 AP5B1 ENSG00000255404 SART1 SNX32 EFEMP2
GH11F065940 1.2 Ensembl ENCODE 11.3 -79.6 -79551 2.4 HDAC1 ATF1 PKNOX1 CBX3 ARNT TBL1XR1 NFXL1 BMI1 RARA ELK1 CTSW SART1 C11orf68 DRAP1 FOSL1 CCDC85B FIBP EFEMP2 CFL1 BANF1
GH11F065636 1.3 FANTOM5 ENCODE 10.4 +221.3 221344 8.2 HDGF PKNOX1 CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A YBX1 GLIS2 ZNF207 SIPA1 KCNK7 RNASEH2C MAP3K11 EHBP1L1 TIGD3 FAM89B SSSCA1 CFL1 SNX32
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CFL1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CFL1 Gene

Chromosome:
11
Start:
65,823,022 bp from pter
End:
65,862,026 bp from pter
Size:
39,005 bases
Orientation:
Minus strand

Genomic View for CFL1 Gene

Genes around CFL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CFL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CFL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFL1 Gene

Proteins for CFL1 Gene

  • Protein details for CFL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23528-COF1_HUMAN
    Recommended name:
    Cofilin-1
    Protein Accession:
    P23528
    Secondary Accessions:
    • B3KUQ1
    • Q53Y87
    • Q9UCA2

    Protein attributes for CFL1 Gene

    Size:
    166 amino acids
    Molecular mass:
    18502 Da
    Quaternary structure:
    • Can bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is a major component of intranuclear and cytoplasmic actin rods.

    Three dimensional structures from OCA and Proteopedia for CFL1 Gene

neXtProt entry for CFL1 Gene

Post-translational modifications for CFL1 Gene

  • Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal (By similarity). Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CFL1 Gene

Domains & Families for CFL1 Gene

Suggested Antigen Peptide Sequences for CFL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23528

UniProtKB/Swiss-Prot:

COF1_HUMAN :
  • Contains 1 ADF-H domain.
  • Belongs to the actin-binding proteins ADF family.
Domain:
  • Contains 1 ADF-H domain.
Family:
  • Belongs to the actin-binding proteins ADF family.
genes like me logo Genes that share domains with CFL1: view

No data available for Gene Families for CFL1 Gene

Function for CFL1 Gene

Molecular function for CFL1 Gene

GENATLAS Biochemistry:
cofilin 1,actin-binding protein,non-muscle type,depolymerisation factor of F-actin to G-actin
UniProtKB/Swiss-Prot Function:
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation (PubMed:11812157, PubMed:15580268, PubMed:21834987, PubMed:23633677). Required for neural tube morphogenesis and neural crest cell migration (By similarity).
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).

Gene Ontology (GO) - Molecular Function for CFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 12361576
GO:0051015 actin filament binding ISS --
GO:1902936 phosphatidylinositol bisphosphate binding IEA --
genes like me logo Genes that share ontologies with CFL1: view
genes like me logo Genes that share phenotypes with CFL1: view

Animal Models for CFL1 Gene

MGI Knock Outs for CFL1:

Animal Model Products

  • Taconic Biosciences Mouse Models for CFL1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CFL1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CFL1 Gene

Localization for CFL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFL1 Gene

Nucleus matrix. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CFL1 gene
Compartment Confidence
extracellular 5
nucleus 5
plasma membrane 4
cytoskeleton 4
cytosol 4
mitochondrion 3

Gene Ontology (GO) - Cellular Components for CFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005622 intracellular IEA --
GO:0005634 nucleus IEA,TAS 16130169
GO:0005737 cytoplasm TAS 16130169
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CFL1: view

Pathways & Interactions for CFL1 Gene

genes like me logo Genes that share pathways with CFL1: view

SIGNOR curated interactions for CFL1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006606 protein import into nucleus IEA --
GO:0007010 cytoskeleton organization IMP 21834987
GO:0007266 Rho protein signal transduction TAS 10436159
GO:0009615 response to virus IEP 16548883
GO:0022604 regulation of cell morphogenesis IMP 21834987
genes like me logo Genes that share ontologies with CFL1: view

Drugs & Compounds for CFL1 Gene

(3) Drugs for CFL1 Gene - From: DrugBank and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lauryl Dimethylamine-N-Oxide Experimental Pharma Target 0

(2) Additional Compounds for CFL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CFL1: view

Transcripts for CFL1 Gene

Unigene Clusters for CFL1 Gene

Cofilin 1 (non-muscle):
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CFL1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CFL1 Gene

No ASD Table

Relevant External Links for CFL1 Gene

GeneLoc Exon Structure for
CFL1
ECgene alternative splicing isoforms for
CFL1

Expression for CFL1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CFL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CFL1 Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for CFL1 Gene

This gene is overexpressed in NK cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CFL1 Gene



Protein tissue co-expression partners for CFL1 Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CFL1 Gene:

CFL1

SOURCE GeneReport for Unigene cluster for CFL1 Gene:

Hs.170622

mRNA Expression by UniProt/SwissProt for CFL1 Gene:

P23528-COF1_HUMAN
Tissue specificity: Widely distributed in various tissues.
genes like me logo Genes that share expression patterns with CFL1: view

Primer Products

Orthologs for CFL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CFL1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CFL1 34 35
  • 99.8 (n)
cow
(Bos Taurus)
Mammalia CFL1 34 35
  • 94.58 (n)
dog
(Canis familiaris)
Mammalia CFL1 34 35
  • 93.37 (n)
mouse
(Mus musculus)
Mammalia Cfl1 34 16 35
  • 93.37 (n)
rat
(Rattus norvegicus)
Mammalia Cfl1 34
  • 91.97 (n)
lizard
(Anolis carolinensis)
Reptilia CFL1 35
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cfl1 34
  • 71.08 (n)
zebrafish
(Danio rerio)
Actinopterygii cfl1 35
  • 75 (a)
OneToOne
Dr.28198 34
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COF1 35 37
  • 41 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4636 35
  • 28 (a)
ManyToMany
-- 35
  • 26 (a)
ManyToMany
Species where no ortholog for CFL1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFL1 Gene

ENSEMBL:
Gene Tree for CFL1 (if available)
TreeFam:
Gene Tree for CFL1 (if available)

Paralogs for CFL1 Gene

Variants for CFL1 Gene

Sequence variations from dbSNP and Humsavar for CFL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs1059681 -- 65,855,366(-) AGTGC(C/G/T)GTCAT upstream-variant-2KB, reference, synonymous-codon
rs111520700 -- 65,858,504(+) TATCC(A/C)ACAGC downstream-variant-500B, upstream-variant-2KB
rs11227332 -- 65,856,268(+) ACGTC(A/G)AGAAA intron-variant, upstream-variant-2KB
rs112357246 -- 65,855,537(+) GCAGA(C/T)GGAAG intron-variant, upstream-variant-2KB
rs112906941 -- 65,857,494(+) CCTCC(A/G)AGCCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CFL1 Gene

Variant ID Type Subtype PubMed ID
nsv555215 CNV loss 21841781
nsv1159905 CNV duplication 26073780
esv2759834 CNV gain 17122850

Variation tolerance for CFL1 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CFL1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CFL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CFL1 Gene

Disorders for CFL1 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CFL1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
corticobasal degeneration
  • cbgd
- elite association - COSMIC cancer census association via MalaCards
Search CFL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CFL1

Genetic Association Database (GAD)
CFL1
Human Genome Epidemiology (HuGE) Navigator
CFL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CFL1
genes like me logo Genes that share disorders with CFL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CFL1 Gene

Publications for CFL1 Gene

  1. Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14. (PMID: 8800436) Gillett G.T. … Povey S. (Ann. Hum. Genet. 1996) 2 3 4 22 64
  2. Association between CFL1 gene polymorphisms and spina bifida risk in a California population. (PMID: 17352815) Zhu H. … Finnell R.H. (BMC Med. Genet. 2007) 3 22 46 64
  3. Dephosphorylation of cofilin in stimulated platelets: roles for a GTP-binding protein and Ca2+. (PMID: 8037689) Davidson M.M. … Haslam R.J. (Biochem. J. 1994) 3 4 22 64
  4. Identification and characterization of a set of conserved and new regulators of cytoskeletal organisation, cell morphology and migration. (PMID: 21834987) Bai S.W. … Ridley A.J. (BMC Biol. 2011) 3 4 64
  5. HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1. (PMID: 20133759) Quintela-Fandino M. … Mak T.W. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 22 64

Products for CFL1 Gene

Sources for CFL1 Gene

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