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Aliases for CFL1 Gene

Aliases for CFL1 Gene

  • Cofilin 1 2 3
  • Cofilin 1 (Non-Muscle) 2 3 5
  • Cofilin, Non-Muscle Isoform 3 4
  • 18 KDa Phosphoprotein 3 4
  • P18 3 4
  • CFL 3 4
  • Epididymis Secretory Protein Li 15 3
  • HEL-S-15 3
  • Cofilin 3

External Ids for CFL1 Gene

Previous HGNC Symbols for CFL1 Gene

  • CFL

Previous GeneCards Identifiers for CFL1 Gene

  • GC11M068156
  • GC11M067303
  • GC11M065872
  • GC11M065397
  • GC11M065378
  • GC11M065622
  • GC11M061948

Summaries for CFL1 Gene

Entrez Gene Summary for CFL1 Gene

  • The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner. Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton. Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the translocation of actin-cofilin complex from cytoplasm to nucleus.[supplied by OMIM, Apr 2004]

GeneCards Summary for CFL1 Gene

CFL1 (Cofilin 1) is a Protein Coding gene. Diseases associated with CFL1 include corticobasal degeneration and pollen allergy. Among its related pathways are Platelet activation, signaling and aggregation and Sertoli-Sertoli Cell Junction Dynamics. GO annotations related to this gene include actin binding. An important paralog of this gene is DSTN.

UniProtKB/Swiss-Prot for CFL1 Gene

  • Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation.

Gene Wiki entry for CFL1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFL1 Gene

Genomics for CFL1 Gene

Regulatory Elements for CFL1 Gene

Genomic Location for CFL1 Gene

Chromosome:
11
Start:
65,823,022 bp from pter
End:
65,862,026 bp from pter
Size:
39,005 bases
Orientation:
Minus strand

Genomic View for CFL1 Gene

Genes around CFL1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CFL1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CFL1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFL1 Gene

Proteins for CFL1 Gene

  • Protein details for CFL1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P23528-COF1_HUMAN
    Recommended name:
    Cofilin-1
    Protein Accession:
    P23528
    Secondary Accessions:
    • B3KUQ1
    • Q53Y87
    • Q9UCA2

    Protein attributes for CFL1 Gene

    Size:
    166 amino acids
    Molecular mass:
    18502 Da
    Quaternary structure:
    • Can bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is a major component of intranuclear and cytoplasmic actin rods.

    Three dimensional structures from OCA and Proteopedia for CFL1 Gene

neXtProt entry for CFL1 Gene

Proteomics data for CFL1 Gene at MOPED

Post-translational modifications for CFL1 Gene

  • Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of Ser-24 may prevent recognition of the nuclear localization signal (By similarity). Phosphorylated via a ARRB1-RAC1-LIMK1-PAK1 cascade upon active ligand stimulation of atypical chemokine receptor ACKR2.
  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CFL1 (Cofilin-1)

No data available for DME Specific Peptides for CFL1 Gene

Domains & Families for CFL1 Gene

Suggested Antigen Peptide Sequences for CFL1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P23528

UniProtKB/Swiss-Prot:

COF1_HUMAN :
  • Contains 1 ADF-H domain.
  • Belongs to the actin-binding proteins ADF family.
Domain:
  • Contains 1 ADF-H domain.
Family:
  • Belongs to the actin-binding proteins ADF family.
genes like me logo Genes that share domains with CFL1: view

No data available for Gene Families for CFL1 Gene

Function for CFL1 Gene

Molecular function for CFL1 Gene

GENATLAS Biochemistry:
cofilin 1,actin-binding protein,non-muscle type,depolymerisation factor of F-actin to G-actin
UniProtKB/Swiss-Prot Function:
Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell morphology and cytoskeletal organization. Required for the up-regulation of atypical chemokine receptor ACKR2 from endosomal compartment to cell membrane, increasing its efficiency in chemokine uptake and degradation.
UniProtKB/Swiss-Prot Induction:
Up-regulated in response to enterovirus 71 (EV71) infection (at protein level).
genes like me logo Genes that share phenotypes with CFL1: view

Animal Models for CFL1 Gene

MGI Knock Outs for CFL1:

Animal Model Products

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CFL1 Gene

Localization for CFL1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFL1 Gene

Nucleus matrix. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side. Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl sulfoxide.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CFL1 Gene COMPARTMENTS Subcellular localization image for CFL1 gene
Compartment Confidence
extracellular 5
nucleus 5
cytoskeleton 4
cytosol 4
plasma membrane 4
mitochondrion 3

Gene Ontology (GO) - Cellular Components for CFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus TAS 16130169
GO:0005737 cytoplasm TAS 16130169
GO:0015629 actin cytoskeleton IEA --
GO:0016020 membrane IDA 19946888
GO:0032587 ruffle membrane IEA --
genes like me logo Genes that share ontologies with CFL1: view

Pathways & Interactions for CFL1 Gene

genes like me logo Genes that share pathways with CFL1: view

SIGNOR curated interactions for CFL1 Gene

Is inactivated by:

Gene Ontology (GO) - Biological Process for CFL1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007266 Rho protein signal transduction TAS 10436159
GO:0007411 axon guidance TAS --
GO:0030168 platelet activation TAS --
GO:0044794 positive regulation by host of viral process IMP 25556234
GO:0045087 innate immune response TAS --
genes like me logo Genes that share ontologies with CFL1: view

Drugs & Compounds for CFL1 Gene

(3) Drugs for CFL1 Gene - From: Novoseek and DrugBank

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Lauryl Dimethylamine-N-Oxide Experimental Pharma Target 0

(2) Additional Compounds for CFL1 Gene - From: Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
genes like me logo Genes that share compounds with CFL1: view

Transcripts for CFL1 Gene

Unigene Clusters for CFL1 Gene

Cofilin 1 (non-muscle):
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CFL1 Gene

No ASD Table

Relevant External Links for CFL1 Gene

GeneLoc Exon Structure for
CFL1
ECgene alternative splicing isoforms for
CFL1

Expression for CFL1 Gene

mRNA expression in normal human tissues for CFL1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CFL1 Gene

This gene is overexpressed in Whole Blood (x5.4).

Protein differential expression in normal tissues from HIPED for CFL1 Gene

This gene is overexpressed in NK cells (6.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CFL1 Gene



SOURCE GeneReport for Unigene cluster for CFL1 Gene Hs.170622

mRNA Expression by UniProt/SwissProt for CFL1 Gene

P23528-COF1_HUMAN
Tissue specificity: Widely distributed in various tissues.
genes like me logo Genes that share expression patterns with CFL1: view

Protein tissue co-expression partners for CFL1 Gene

- Elite partner

Primer Products

In Situ Assay Products

Orthologs for CFL1 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CFL1 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CFL1 35
  • 94.58 (n)
  • 99.4 (a)
CFL1 36
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CFL1 35
  • 93.37 (n)
  • 100 (a)
CFL1 36
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cfl1 35
  • 93.37 (n)
  • 98.8 (a)
Cfl1 16
Cfl1 36
  • 72 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CFL1 35
  • 99.8 (n)
  • 100 (a)
CFL1 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cfl1 35
  • 91.97 (n)
  • 99.4 (a)
lizard
(Anolis carolinensis)
Reptilia CFL1 36
  • 69 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cfl1 35
  • 71.08 (n)
  • 78.31 (a)
zebrafish
(Danio rerio)
Actinopterygii Dr.28198 35
cfl1 36
  • 75 (a)
OneToOne
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes COF1 36
  • 41 (a)
OneToMany
COF1 38
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 26 (a)
ManyToMany
CSA.4636 36
  • 28 (a)
ManyToMany
Species with no ortholog for CFL1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFL1 Gene

ENSEMBL:
Gene Tree for CFL1 (if available)
TreeFam:
Gene Tree for CFL1 (if available)

Paralogs for CFL1 Gene

Paralogs for CFL1 Gene

(2) SIMAP similar genes for CFL1 Gene using alignment to 7 proteins:

genes like me logo Genes that share paralogs with CFL1: view

Variants for CFL1 Gene

Sequence variations from dbSNP and Humsavar for CFL1 Gene

SNP ID Clin Chr 11 pos Sequence Context AA Info Type
rs7125986 -- 65,857,463(+) TCCCG(A/C)ACGGG intron-variant
rs7947741 -- 65,857,766(+) GCGCG(C/G)CCCTA intron-variant
rs7947929 -- 65,857,720(+) TCGCC(A/G)CCCCC intron-variant
rs12800903 -- 65,858,112(+) GAAAC(G/T)AAAAG utr-variant-5-prime
rs115074329 -- 65,858,127(+) GGGCA(C/G)CGAGA utr-variant-5-prime

Structural Variations from Database of Genomic Variants (DGV) for CFL1 Gene

Variant ID Type Subtype PubMed ID
nsv897736 CNV Loss 21882294
dgv393e1 CNV Complex 17122850
dgv1185n71 CNV Loss 21882294
nsv897763 CNV Loss 21882294
nsv897764 CNV Loss 21882294
nsv897766 CNV Loss 21882294

Variation tolerance for CFL1 Gene

Residual Variation Intolerance Score: 40.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.84; 17.53% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CFL1 Gene

HapMap Linkage Disequilibrium report
CFL1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CFL1 Gene

Disorders for CFL1 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CFL1 Gene - From: GeneCards

Disorder Aliases PubMed IDs
corticobasal degeneration
  • cbgd
pollen allergy
  • hay fever
- elite association - COSMIC cancer census association via MalaCards
Search CFL1 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CFL1

Genetic Association Database (GAD)
CFL1
Human Genome Epidemiology (HuGE) Navigator
CFL1
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CFL1
genes like me logo Genes that share disorders with CFL1: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CFL1 Gene

Publications for CFL1 Gene

  1. Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14. (PMID: 8800436) Gillett G.T. … Povey S. (Ann. Hum. Genet. 1996) 2 3 4 23 67
  2. HUNK suppresses metastasis of basal type breast cancers by disrupting the interaction between PP2A and cofilin-1. (PMID: 20133759) Quintela-Fandino M. … Mak T.W. (Proc. Natl. Acad. Sci. U.S.A. 2010) 3 23
  3. Essential role of cofilin-1 in regulating thrombin-induced RelA/p65 nuclear translocation and intercellular adhesion molecule 1 (ICAM-1) expression in endothelial cells. (PMID: 19483084) Fazal F. … Rahman A. (J. Biol. Chem. 2009) 3 23
  4. Association between CFL1 gene polymorphisms and spina bifida risk in a California population. (PMID: 17352815) Zhu H. … Finnell R.H. (BMC Med. Genet. 2007) 3 23
  5. Differential involvement of destrin and cofilin-1 in the control of invasive properties of Isreco1 human colon cancer cells. (PMID: 17583572) Estornes Y. … Abello J. (Int. J. Cancer 2007) 3 23

Products for CFL1 Gene

Sources for CFL1 Gene

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