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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CFL1 Gene

protein-coding GIFtS: 65
GCID: GC11M065622

cofilin 1 (non-muscle)

(Previous symbol: CFL)

Explore 42 diseases affiliated with
CFL1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cofilin 1 (Non-Muscle)¹ ²
CFL¹ ² ³
Cofilin, Non-Muscle Isoform² ³
18 KDa Phosphoprotein² ³
P18¹
Cofilin-1¹

External Ids:	HGNC: 1874¹	Entrez Gene: 1072²	Ensembl: ENSG00000172757⁷	OMIM: 601442⁵	UniProtKB: P23528³

Export aliases for CFL1 gene to outside databases

Previous GC identifers: GC11M068156 GC11M067303 GC11M065872 GC11M065397 GC11M065378 GC11M061948

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CFL1:

The protein encoded by this gene can polymerize and depolymerize F-actin and G-actin in a pH-dependent manner.

Increased phosphorylation of this protein by LIM kinase aids in Rho-induced reorganization of the actin cytoskeleton.

Cofilin is a widely distributed intracellular actin-modulating protein that binds and depolymerizes filamentous

F-actin and inhibits the polymerization of monomeric G-actin in a pH-dependent manner. It is involved in the

translocation of actin-cofilin complex from cytoplasm to nucleus.(supplied by OMIM, Apr 2004)

UniProtKB/Swiss-Prot: COF1_HUMAN, P23528

Function: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton

dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell

morphology and cytoskeletal organization

Gene Wiki entry for CFL1 (Cofilin 1)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000011.9 NC_018922.1 NT_167190.1

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CFL1 gene promoter:
p53 AP-1 Pax-6 ATF-2 Lmo2 E47 GATA-2 COMP1 c-Jun
Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 3): CFL1 promoter sequence

Search SABiosciences Chromatin IP Primers for CFL1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CFL1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 11q13 Ensembl cytogenetic band: 11q13.1 HGNC cytogenetic band: 11q13.1

CFL1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CFL1 gene location

GeneLoc information about chromosome 11 GeneLoc Exon Structure

GeneLoc location for GC11M065622: view genomic region (about GC identifiers)

Start:	65,590,493 bp from pter	End:	65,629,497 bp from pter
Size:	39,005 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: COF1_HUMAN, P23528 (See protein sequence)

Recommended Name: Cofilin-1

Size: 166 amino acids; 18502 Da

Subunit: Can bind G- and F-actin in a 1:1 ratio of cofilin to actin. It is a major component of intranuclear and

cytoplasmic actin rods

Subcellular location: Nucleus matrix. Cytoplasm, cytoskeleton. Cell projection, ruffle membrane; Peripheral membrane

protein; Cytoplasmic side. Cell projection, lamellipodium membrane; Peripheral membrane protein; Cytoplasmic side.

Note=Colocalizes with the actin cytoskeleton in membrane ruffles and lamellipodia. Detected at the cleavage furrow and

contractile ring during cytokinesis. Almost completely in nucleus in cells exposed to heat shock or 10% dimethyl

sulfoxide

3 PDB 3D structures from and Proteopedia for CFL1:

1Q8G (3D)

1Q8X (3D)

3J0S (3D)

Secondary accessions: B3KUQ1 Q53Y87 Q9UCA2

Explore the universe of human proteins at neXtProt for CFL1: NX_P23528

Post-translational modifications:

Inactivated by phosphorylation on Ser-3. Phosphorylated on Ser-3 in resting cells (By similarity). Dephosphorylated by

PDXP/chronophin; this restores its activity in promoting actin filament depolymerization. The phosphorylation of

Ser-24 may prevent recognition of the nuclear localization signal (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P23528

CFL1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_005498.1

ENSEMBL proteins:

ENSP00000432660 ENSP00000432155 ENSP00000433910 ENSP00000432226 ENSP00000431696

ENSP00000433131 ENSP00000436431 ENSP00000436899 ENSP00000433308 ENSP00000432153

ENSP00000309629

Reactome Protein details: P23528
Human Recombinant Protein Products for CFL1:

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	Browse Sino Biological Recombinant Proteins
	ProSpec Recombinant Protein for CFL1
	Uscn Proteins for CFL1

Gene Ontology (GO): 5/8 cellular component terms (GO ID links to tree view) (see all 8): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005622	intracellular	--	--
GO:0005634	nucleus	TAS	16130169
GO:0005737	cytoplasm	TAS	16130169
GO:0005856	cytoskeleton	--	--
GO:0016363	nuclear matrix	IEA	--

CFL1 for ontologies About GeneDecksing

CFL1 Antibody Products:

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	Abcam antibodies for CFL1
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Assay Products for CFL1:

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	GenScript Custom Assay Services for CFL1
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	Uscn ELISAs and CLIAs for CFL1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CFL1 for domains About GeneDecksing

3 InterPro domains/families:

IPR027234 Cofilin_1/2

IPR002108 Actin-bd_cofilin/tropomyosin

IPR017904 ADF/Cofilin/Destrin

Graphical View of Domain Structure for InterPro Entry P23528

ProtoNet protein and cluster: P23528

1 Blocks protein family: IPB002108 Actin-binding

UniProtKB/Swiss-Prot: COF1_HUMAN, P23528

Similarity: Belongs to the actin-binding proteins ADF family

Similarity: Contains 1 ADF-H domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: COF1_HUMAN, P23528

Function: Binds to F-actin and exhibits pH-sensitive F-actin depolymerizing activity. Regulates actin cytoskeleton

dynamics. Important for normal progress through mitosis and normal cytokinesis. Plays a role in the regulation of cell

morphology and cytoskeletal organization

Induction: Up-regulated in response to enterovirus 71 (EV71) infection (at protein level)

Genatlas biochemistry entry for CFL1:

cofilin 1,actin-binding protein,non-muscle type,depolymerisation factor of F-actin to G-actin

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003779	actin binding	IEA	--
GO:0005515	protein binding	IPI	16713569

CFL1 for ontologies About GeneDecksing

Phenotypes:
8 GenomeRNAi human phenotypes for CFL1:

Abundance of large cells with	Increased Salmonella enterica	Increased Salmonella enterica	Increased Salmonella enterica
Increased Salmonella enterica	Increased Salmonella enterica	Increased Salmonella-containin	Synthetic lethal with Ras

12 MGI mutant phenotypes (inferred from 4 alleles) (MGI details for Cfl1):

behavior/neurological	cellular	embryogenesis	growth/size	homeostasis/metabolism
integument	mortality/aging	nervous system	no phenotypic analysis	normal
renal/urinary system	vision/eye

CFL1 for phenotypes About GeneDecksing

Animal Models:
Mouse knock-out Cfl1^tm1.2Wit for CFL1

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CFL1

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		hsa-miR-3128 hsa-miR-596 hsa-miR-185* hsa-miR-1271 hsa-miR-486-3p hsa-miR-3916 hsa-miR-3125 hsa-miR-342-5p

		SwitchGear 3'UTR luciferase reporter plasmid: CFL1 3' UTR sequence

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In Situ Assay
Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CFL1

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways - 5/33 super-pathways (see all 33) About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Cell adhesion_Integrin-mediated cell adhesion and migration

Cell adhesion_Integrin-mediated cell adhesion and migration	1.00	Cytoskeleton remodeling Regulation of actin cytoskeleton by Rho GTPases	0.49
Cell adhesion Integrin-mediated cell adhesion and migration	1.00	Cytoskeleton remodeling Fibronectin-binding integrins in cell motility	0.32
Cytoskeleton remodeling_Regulation of actin cytoskeleton by Rho GTPases	0.49	Cytoskeleton remodeling_Fibronectin-binding integrins in cell motility	0.32

G-protein signaling_RAC1 in cellular process

	Cytoskeleton remodeling_CDC42 in cellular processes	0.37			RAC1 signaling pathway	0.34
	Cytoskeleton remodeling CDC42 in cellular processes	0.37			CDC42 signaling events	0.17

Immune response _CCR3 signaling in eosinophils

	Immune response _CCR3 signaling in eosinophils	1.00			Inhibitory action of Lipoxins on neutrophil migration	0.51
	Immune response CCR3 signaling in eosinophils	1.00

Actin Nucleation by ARP-WASP Complex

	Actin Nucleation and Branching	0.66			CDC42 Pathway	0.34
	RhoA Pathway	0.35

Platelet activation, signaling and aggregation

Platelet activation, signaling and aggregation

1.00

Hemostasis

0.43

Pathway sources
See GeneCards unified pathways
Show all pathways

5/10 EMD Millipore Pathways for CFL1 (see all 10)

	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Cytoskeleton remodeling CDC42 in cellular processes
	Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
	Selected targets of GCR-alpha
	Cytoskeleton remodeling Slit-Robo signaling

5/15 Downloadable PowerPoint Slides of QIAGEN Pathway Central Maps for CFL1 (see all 15)

	RhoA Pathway
	Sertoli-Sertoli Cell Junction Dynamics
	Actin-Based Motility by Rho Family GTPases
	Guidance Cues and Growth Cone Motility
	Internalin Pathway

1 Cell Signaling Technology (CST) Pathway for CFL1

Cytoskeletal Signaling

5/10 GeneGo (Thomson Reuters) Pathways for CFL1 (see all 10)

	Cytoskeleton remodeling CDC42 in cellular processes
	Cytoskeleton remodeling Role of PKA in cytoskeleton reorganisation
	Cytoskeleton remodeling Fibronectin-binding integrins in cell motility
	Neurophysiological process Receptor-mediated axon growth repulsion
	Development Slit-Robo signaling

5/6 BioSystems Pathways for CFL1 (see all 6)

	G13 Signaling Pathway
	Regulation of Actin Cytoskeleton
	CDC42 signaling events
	CXCR4-mediated signaling events
	RAC1 signaling pathway

5/12 Reactome Pathways for CFL1 (see all 12)

	Hemostasis
	Developmental Biology
	Fcgamma receptor (FCGR) dependent phagocytosis
	Response to elevated platelet cytosolic Ca2+
	Semaphorin interactions

4 Kegg Pathways (Kegg details for CFL1):

	Axon guidance
	Fc gamma R-mediated phagocytosis
	Regulation of actin cytoskeleton
	Pertussis

CFL1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CFL1

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

5/241 Interacting proteins for CFL1 (P23528^{1, 2, 3} ENSP00000309629⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 241)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0000910	cytokinesis	IEA	--
GO:0001755	neural crest cell migration	IEA	--
GO:0001842	neural fold formation	IEA	--
GO:0002576	platelet degranulation	TAS	--
GO:0006468	protein phosphorylation	IEA	--

CFL1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

CFL1 for compounds About GeneDecksing

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CFL1

1 DrugBank Compound for CFL1 About this table

Compound	Synonyms	CAS #	Type	Actions	PubMed Ids
Lauryl Dimethylamine-N-Oxide	--	--	target	--	10592235

4 Novoseek chemical compound relationships for CFL1 gene About this table

Compound	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
isocitrate	54.3	1	17269733 (1)
superoxide	14.6	3	19288589 (1), 17320137 (1), 18335753 (1)
atp	0	1	16222722 (1)
calcium	0	3	8037689 (1)

Search CenterWatch for drugs/clinical trials and news about CFL1 / COF1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, Sirion Biotech, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CFL1 gene:

NM_005507.2

Unigene Cluster for CFL1:

Cofilin 1 (non-muscle)

Hs.170622 [show with all ESTs]

Unigene Representative Sequence: BM462286

15 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000530157 ENST00000527752 ENST00000525710 ENST00000525451(uc001ofs.3 uc001oft.3)

ENST00000530945 ENST00000527344 ENST00000531407 ENST00000524553 ENST00000534769

ENST00000531413 ENST00000532134 ENST00000530413 ENST00000534784 ENST00000526975

ENST00000308162

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		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CFL1
		8/21 QIAGEN miScript miRNA Assays for microRNAs that regulate CFL1 (see all 21):
		hsa-miR-3128 hsa-miR-596 hsa-miR-185* hsa-miR-1271 hsa-miR-486-3p hsa-miR-3916 hsa-miR-3125 hsa-miR-342-5p

		SwitchGear 3'UTR luciferase reporter plasmid: CFL1 3' UTR sequence

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Additional cDNA sequence:

AK097690.1 AK303614.1 BC011005.2 BC012265.1 BC012318.1 BC018256.2 BC024975.1 BT006846.1

D00682.1 HM370399.1 U21909.1 X95404.1

24/79 DOTS entries (see all 79):

DT.100034533 DT.95300732 DT.92469951 DT.95257655 DT.95257774 DT.95257650 DT.100710996 DT.453374

DT.100710974 DT.100710983 DT.120689975 DT.95257692 DT.120690019 DT.120690158 DT.95257673 DT.100711015

DT.120690035 DT.92469974 DT.100711007 DT.100710990 DT.95314585 DT.100710991 DT.120690037 DT.92469996

24/2886 AceView cDNA sequences (see all 2886):

BM988917 BU527582 CB124979 CR598143 BM455139 BE018272 CR591283 AA576832

BQ641888 BM993307 BQ005722 AI672937 W72739 CB156908 AA319490 BQ068189

BQ064959 BM913496 CB127486 AU151344 AI685940 T35473 CB137167 BM826201

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CFL1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: GAAGCAGGAC

About this image

CFL1 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

2 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Kidney

Atrioventricular Node

Atrioventricular Node Cells

Myocardium

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CFL1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CFL1

SOURCE GeneReport for Unigene cluster: Hs.170622

UniProtKB/Swiss-Prot: COF1_HUMAN, P23528

Tissue specificity: Widely distributed in various tissues

SABiosciences Expression via Pathway-Focused PCR Arrays including CFL1:

Cytoskeleton Regulators in human mouse rat

Apoptosis 384HT in human mouse rat

Cell Motility in human mouse rat

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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CFL1

In Situ
Assay Products:

Search Advanced Cell Diagnostics for RNAscope RNA in situ hybridization assays for CFL1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of eukaryotes.

Orthologs for CFL1 gene from 7/25 species (see all 25) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
lizard (Anolis carolinensis)	Reptilia	CFL1⁶	--	79(a)	1 ↔ 1	AAWZ02038494(1421-3664)
African clawed frog (Xenopus laevis)	Amphibia	BC044691.1²	--	75.98(n)		BC044691.1
zebrafish (Danio rerio)	Actinopterygii	Dr.28198²	Danio rerio clone RZ151A2B11 muscle cofilin 2 (CFL2) more	79.21(n)		AY398324.1
fruit fly (Drosophila melanogaster)	Insecta	tsr⁶ CG6873⁶	--	34(a) 28(a)	many ↔ many many ↔ many	2R(19931971-19934359) X(18633249-18633928)
worm (Caenorhabditis elegans)	Secernentea	unc-60⁶	Actin-depolymerizing factor 1, isoforms a/b	20(a)	1 → many	V(1474786-1479582)
thale cress (Arabidopsis thaliana)	eudicotyledons	ATADF4⁶ ADF2⁶ (see all 12)	actin depolymerizing factor 2 (see all 12)	36(a) 33(a) (see all 12)	many ↔ many many ↔ many (see all 12)	5(24122412-24123912) 3(16907451-16908999)
rice (Oryza sativa)	Liliopsida	-- -- (see all 10)	actin-depolymerizing factor, putative, expressed (see all 10)	33(a) 32(a) (see all 10)	many ↔ many many ↔ many (see all 10)	2(26914023-26916159) 4(27634011-27634994)

ENSEMBL Gene Tree for CFL1 (if available)
TreeFam Gene Tree for CFL1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CFL1 gene

CFL2² DSTN²

2 SIMAP similar genes for CFL1 using alignment to 7 protein entries: COF1_HUMAN (see all proteins):

CFL2 DSTN

CFL1 for paralogs About GeneDecksing

5/11 Pseudogenes.org Pseudogenes for CFL1 (see all 11)
PGOHUM00000238876 PGOHUM00000257962 PGOHUM00000257995 PGOHUM00000243889 PGOHUM00000244022

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 11 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs142117713^1,2		--	65621860(+)	`TGACCC/TTCATA`	1	--	ds500¹		0	--	--	--	--
rs117871119^1,2	F	--	65621888(+)	`CAGGGA/GAGACA`	1	--	ds500¹		1		EA	120
rs150460822^1,2		--	65621927(+)	`TCTGAC/GTTGCC`	1	--	ds500¹		0	--	--	--	--
rs138305476^1,2		--	65621932(+)	`CTTGCC/GTATCA`	1	--	ds500¹		0	--	--	--	--
rs188792804^1,2		--	65621966(+)	`ACAGAA/GTATCA`	1	--	ds500¹		0	--	--	--	--
rs117370256^1,2		--	65621994(+)	`ATCCAG/AGCAAG`	1	--	ds500¹		1		EA	120
rs635375^1,2	C,F,A,H	--	65621995(+)	`TCCAGG/ACAAGG`	1	--	ds500¹		24		EA NA MN NS WA	2744
rs181806885^1,2		--	65621998(+)	`AGGCAA/GGGCTA`	1	--	ds500¹		0	--	--	--	--
rs149641509^1,2		--	65622026(+)	`GCATAA/CATCAC`	1	--	ds500¹		0	--	--	--	--
rs186307039^1,2		--	65622035(+)	`ACTTCC/TGCTGG`	1	--	ds500¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CFL1 (65590493 - 65629497 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CFL1
1 CNV: 3855

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CFL1 for disorders           About GeneDecksing

OMIM gene information: 601442    OMIM disorders: --

20/42 diseases for CFL1 (see all 42):    About MalaCards

spinal muscular atrophy corticobasal degeneration spina bifida muscular atrophy

laryngeal squamous cell carcinoma dent disease squamous cell carcinoma myotonic dystrophy

epithelial ovarian cancer endometritis keratoconus laryngitis

ovarian cancer colon adenocarcinoma proteinuria parkinson's disease

rhabdomyosarcoma pertussis hepatocellular carcinoma neurodegeneration

2 Novoseek disease relationships for CFL1 gene About this table

Disease	-log (P-Val)	Hits	PubMed IDs for Articles with Shared Sentences (# sentences)
shock	0	1	12922171 (1)
tumors	0	2	18401453 (1), 2278968 (1)

Human Genome Epidemiology (HuGE) Navigator: CFL1 (1 document)

Export disorders for CFL1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CFL1 gene, integrated from 9 sources (see all 213):
(articles sorted by number of sources associating them with CFL1)

Utopia: connect your pdf to the dynamic
world of online information

Mapping of human non-muscle type cofilin (CFL1) to chromosome 11q13 and muscle-type cofilin (CFL2) to chromosome 14. (PubMed id 8800436)^{1, 2, 3, 9} Gillett G.T.... Povey S. (1996)
Dephosphorylation of cofilin in stimulated platelets: roles for a GTP-binding protein and Ca2+. (PubMed id 8037689)^{1, 2, 9} Davidson M.M. and Haslam R.J. (1994)
Transcriptomic and proteomic analyses of rhabdomyosarcoma cells reveal differential cellular gene expression in response to enterovirus 71 infection. (PubMed id 16548883)^{1, 2} Leong W.F. and Chow V.T. (2006)
Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. (PubMed id 17081983)^{1, 2} Olsen J.V....Mann M. (2006)
Immunoaffinity profiling of tyrosine phosphorylation in cancer cells. (PubMed id 15592455)^{1, 2} Rush J.... Comb M.J. (2005)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
Solution structure of human cofilin: actin binding, pH sensitivity, and relationship to actin-depolymerizing factor. (PubMed id 14627701)^{1, 2} Pope B.J.... Ball L.J. (2004)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Exploring proteomes and analyzing protein processing by mass spectrometric identification of sorted N-terminal peptides. (PubMed id 12665801)^{1, 2} Gevaert K.... Vandekerckhove J. (2003)
Cofilin phosphorylation and actin polymerization by NRK/NESK, a member of the germinal center kinase family. (PubMed id 12837278)^{1, 2} Nakano K.... Kitamura N. (2003)

(in PubMed, OMIM, and NCBI Bookshelf)
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		AND	OR
Aliases
Disorders
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 1072	HGNC: 1874	AceView: CFL1andEFEMP2	Ensembl:ENSG00000172757	euGenes: HUgn1072
ECgene: CFL1	Kegg: 1072	H-InvDB: CFL1

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CFL1	Pharmacogenomics, SNPs, Pathways
ATLAS Chromosomes in Cancer entry for CFL1	Genetics and Cytogenetics in Oncology and Haematology
Wikipedia	http://en.wikipedia.org/wiki/Cofilin

Intellectual Property for CFL1 gene
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Patent Information for CFL1 gene:
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