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CFHR5 Gene

protein-coding   GIFtS: 55
GCID: GC01P196946

Complement Factor H-Related 5


(Previous symbol: CFHL5)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Complement Factor H-Related 51 2     CFHR5D2 5
CFHL51 2 3 5     Factor H Related Protein 51
FHR52 3 5     Complement Factor H-Related Protein 52
FHR-52 3     Factor H-Related Protein 52

External Ids:    HGNC: 246681   Entrez Gene: 814942   Ensembl: ENSG000001343897   OMIM: 6085935   UniProtKB: Q9BXR63   

Export aliases for CFHR5 gene to outside databases

Previous GC identifers: GC01P195213 GC01P168103


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CFHR5 Gene:
This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene
family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The
protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region
within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats
being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in
a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this
gene have been associated, but not causally linked, with two different forms of kidney disease:
membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). (provided by
RefSeq, Jan 2010)

GeneCards Summary for CFHR5 Gene:
CFHR5 (complement factor H-related 5) is a protein-coding gene. Diseases associated with CFHR5 include dense deposit disease, and dense deposit disease/membranoproliferative glomerulonephritis type ii. An important paralog of this gene is CFHR4.

UniProtKB/Swiss-Prot: FHR5_HUMAN, Q9BXR6
Function: Involved in complement regulation

Gene Wiki entry for CFHR5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NC_018912.2  NT_004487.20  
Regulatory elements:
   Regulatory transcription factor binding sites in the CFHR5 gene promoter:
         PPAR-gamma1   Zic1   POU3F1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCFHR5 promoter sequence
   Search Chromatin IP Primers for CFHR5

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CFHR5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31.3   Ensembl cytogenetic band:  1q31.3   HGNC cytogenetic band: 1q31.3

CFHR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CFHR5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P196946:  view genomic region     (about GC identifiers)

Start:
196,946,667 bp from pter      End:
196,978,804 bp from pter
Size:
32,138 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FHR5_HUMAN, Q9BXR6 (See protein sequence)
Recommended Name: Complement factor H-related protein 5 precursor  
Size: 569 amino acids; 64419 Da
Subunit: Binds C3b in vitro
Secondary accessions: Q2NKK2

Explore the universe of human proteins at neXtProt for CFHR5: NX_Q9BXR6

Explore proteomics data for CFHR5 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn126, Asn400
  • Modification sites at PhosphoSitePlus

  • See CFHR5 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_110414.1  
    ENSEMBL proteins: 
     ENSP00000256785   ENSP00000356384  

    CFHR5 Human Recombinant Protein Products:

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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    complement: Complement system

    1 InterPro protein domain:
     IPR000436 Sushi_SCR_CCP

    Graphical View of Domain Structure for InterPro Entry Q9BXR6

    ProtoNet protein and cluster: Q9BXR6

    1 Blocks protein domain: IPB000436 Sushi domain/SCR domain/CCP module

    UniProtKB/Swiss-Prot: FHR5_HUMAN, Q9BXR6
    Similarity: Contains 9 Sushi (CCP/SCR) domains


    CFHR5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FHR5_HUMAN, Q9BXR6
    Function: Involved in complement regulation

    Animal Models:

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CFHR5
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CFHR5
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CFHR5

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    3 qRT-PCR Assays for microRNAs that regulate CFHR5:
    hsa-miR-548a-3p hsa-miR-187* hsa-miR-548e
    SwitchGear 3'UTR luciferase reporter plasmidCFHR5 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CFHR5

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    Sino Biological Human cDNA Clone for CFHR5
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    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CFHR5

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFHR5


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FHR5_HUMAN, Q9BXR6: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    endoplasmic reticulum1

    Gene Ontology (GO): 1 cellular component term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS11058592

    CFHR5 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CFHR5
    Interactions:

        Search GeneGlobe Interaction Network for CFHR5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CFHR5 (Q9BXR63 ENSP000002567854) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C3P010243, ENSP000002459074I2D: score=2 STRING: ENSP00000245907
    MAXENSP000003514904STRING: ENSP00000351490
    MYCENSP000003672074STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006957complement activation, alternative pathway NAS11058592

    CFHR5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CFHR5 (FHR5)

    1 Novoseek inferred chemical compound relationship for CFHR5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparin 26.1 2 15879123 (2)



    CFHR5 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CFHR5 gene: 
    NM_030787.3  

    Unigene Cluster for CFHR5:

    Complement factor H-related 5
    Hs.282594  [show with all ESTs]
    Unigene Representative Sequence: NM_030787
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256785 ENST00000367414(uc001gts.4)

    miRNA
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    Block miRNA regulation of human, mouse, rat CFHR5 using miScript Target Protectors
    3 qRT-PCR Assays for microRNAs that regulate CFHR5:
    hsa-miR-548a-3p hsa-miR-187* hsa-miR-548e
    SwitchGear 3'UTR luciferase reporter plasmidCFHR5 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CFHR5
    Predesigned siRNA for gene silencing in human, mouse, rat CFHR5
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    GenScript: all cDNA clones in your preferred vector: CFHR5 (NM_030787)
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    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CFHR5
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CFHR5
      QuantiTect SYBR Green Assays in human, mouse, rat CFHR5
      QuantiFast Probe-based Assays in human, mouse, rat CFHR5

    Additional mRNA sequence: 

    AF295327.1 AK314026.1 BC026282.1 BC111773.1 

    2 DOTS entries:

    DT.91990021  DT.91743704 

    7 AceView cDNA sequences:

    NM_030787 BX951489 BC026282 BG568555 AF295327 BG616762 AV697083 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CFHR5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAATTTTA
    CFHR5 Expression
    About this image

    CFHR5 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CFHR5 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.282594

    UniProtKB/Swiss-Prot: FHR5_HUMAN, Q9BXR6
    Tissue specificity: Expressed by the liver and secreted in plasma

        Custom PCR Arrays for CFHR5
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFHR5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CFHR5 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia CFHR51 complement factor H-related 5 78.07(n)
    64.37(a)
      490262  XM_547381.5  XP_547381.3 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    16(a)
    1 → many
    8(2641142-2673492)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    21(a)
    many ↔ many
    GL343432.1(114427-178236)
    zebrafish
    (Danio rerio)
    Actinopterygii cfhl26
    complement factor H like 2
    14(a)
    many ↔ many
    22(24151024-24165307) ENSDARG00000056778


    ENSEMBL Gene Tree for CFHR5 (if available)
    TreeFam Gene Tree for CFHR5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CFHR5 gene
    CFHR42  F13B2  CFHR22  CFHR32  CFH2  CFHR12  
    8 SIMAP similar genes for CFHR5 using alignment to 3 protein entries:     FHR5_HUMAN (see all proteins):
    CFHL1P    HF    CFHR2    CFH    CFHR1    CFHR3
    CFHR4    CR1

    CFHR5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CFHR5 (see all 897)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358274
    A breast cancer sample4--see VAR_0358272 N S mis40--------
    rs1113275891,2,,4
    C,Funtested1203508321(+) CTGAAG/CTAGAC 2 /L /V mis13Minor allele frequency- C:0.01CSA NA EU 5819
    rs2012656641,2,,4
    Cuntested1203512673(+) CGATGA/G/TCAATC 2 W C mis10--------
    rs3182407541,2,,4
    Cunknown1203494051(+) ACATCC/G/TGGAAG 2 R L mis10--------
    rs358104891,2
    C--168126111(+) TATATG/ATATAT 1 -- int11Minor allele frequency- A:0.00NA 2
    rs574370381,2
    C--196949722(+) TATAC-/GTGTGTG 1 -- int10--------
    rs715675941,2
    C--196951808(+) TCTCA-/AAAAAA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1121732391,2
    F--196955869(+) TATGTG/ATGCCG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs75509701,2
    C--196956140(+) tttctC/Tcacat 1 -- int10--------
    rs75279101,2
    C--196956198(+) aactgA/Gtgtga 1 -- int10--------

    HapMap Linkage Disequilibrium report for CFHR5 (196946667 - 196978804 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CFHR5 (see all 14):    About this table    
    Variant IDTypeSubtypePubMed ID
    esv2676788CNV Deletion23128226
    esv2721051CNV Deletion23290073
    nsv8702CNV Loss18304495
    nsv469599CNV Loss16826518
    nsv524689CNV Loss19592680
    nsv528460CNV Gain19592680
    dgv12e55CNV Gain17911159
    nsv471614CNV Gain+Loss15918152
    nsv428290CNV Gain+Loss18775914
    essv19099CNV CNV17122850

    Human Gene Mutation Database (HGMD): CFHR5
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CFHR5
    DNA2.0 Custom Variant and Variant Library Synthesis for CFHR5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 608593   
    OMIM disorders: 614809  
    UniProtKB/Swiss-Prot: FHR5_HUMAN, Q9BXR6
  • Note=Defects in CFHR5 have been found in patients with atypical hemolytic uremic syndrome and may
    contribute to the disease. Atypical hemolytic uremic syndrome is a complex genetic disease characterized by
    microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and
    diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher
    death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical
    hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the
    complement cascade system. Other genes may play a role in modifying the phenotype
  • CFHR5 deficiency (CFHR5D) [MIM:614809]: A progressive disease characterized by glomerulonephritis,
    hematuria, renal failure, end-stage renal disease, subendothelial and mesangial glomerular C3 deposits, mesangial
    matrix expansion, increased glomerular cellularity, and segmental capillary wall thickening. Hematuria may become
    apparent after respiratory infections. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • Selected diseases for CFHR5 (see all 24):    About MalaCards
    dense deposit disease    dense deposit disease/membranoproliferative glomerulonephritis type ii    nephropathy due to cfhr5 deficiency    membranoproliferative glomerulonephritis
    cfhr5-related dense deposit disease / membranoproliferative glomerulonephritis type ii    glomerulonephritis    kuhnt-junius degeneration    atypical hemolytic-uremic syndrome
    hemolytic-uremic syndrome    alport syndrome    kidney disease    otitis media
    age related macular degeneration    hemolytic anemia    diarrhea    thrombocytopenia
    non-hodgkin lymphoma    hodgkin's lymphoma    breast and colorectal cancer    hepatitis b

    1 disease from the University of Copenhagen DISEASES database for CFHR5:
    Alport syndrome

    CFHR5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    GeneTests: CFHR5
    GeneReviews: CFHR5
    Genetic Association Database (GAD): CFHR5
    Human Genome Epidemiology (HuGE) Navigator: CFHR5 (9 documents)

    Export disorders for CFHR5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CFHR5 gene, integrated from 10 sources (see all 33):
    (articles sorted by number of sources associating them with CFHR5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human factor H-related protein 5 (FHR-5). A new complement-associated protein. (PubMed id 11058592)1, 2, 3, 9 McRae J.L.... Murphy B.F. (J. Biol. Chem. 2001)
    2. Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome. (PubMed id 20513133)1, 2, 4, 9 Maga T.K.... Smith R.J.H. (Hum. Mutat. 2010)
    3. Identification of a mutation in complement factor H-related protein 5 in patients of Cypriot origin with glomerulonephritis. (PubMed id 20800271)1, 2, 4 Gale D.P.... Pickering M.C. (Lancet 2010)
    4. Genetic analysis of complement factor H related 5, CFHR5, in patients with age-related macular degeneration. (PubMed id 19365580)1, 4, 9 Narendra U....Hagstrom S.A. (Mol. Vis. 2009)
    5. Genetic analysis of the complement factor H related 5 gene in haemolytic uraemic syndrome. (PubMed id 17000000)1, 4, 9 Monteferrante G....Noris M. (Mol. Immunol. 2007)
    6. Atypical hemolytic uremic syndrome and genetic aberrations in the complement factor H-related 5 gene. (PubMed id 22622361)1, 2 Westra D.... van den Heuvel L.P. (J. Hum. Genet. 2012)
    7. Epidemiological approach to identifying genetic predispositions for atypical hemolytic uremic syndrome. (PubMed id 20059470)1, 4 Sullivan M....Neumann H.P. (Ann. Hum. Genet. 2010)
    8. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. (PubMed id 19344414)1, 4 Cerhan J.R....Slager S.L. (Br. J. Haematol. 2009)
    9. The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration. (PubMed id 18541031)1, 4 Zhang H....Deangelis M.M. (BMC Med. Genet. 2008)
    10. Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications. (PubMed id 17438673)1, 4 Hageman G.S....Dean M. (Ann. Med. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    Aliases
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    Free Text  

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 81494 HGNC: 24668 AceView: CFHL5 Ensembl:ENSG00000134389 euGenes: HUgn81494
    ECgene: CFHR5 H-InvDB: CFHR5

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CFHR5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CFHR5 gene:
    Search GeneIP for patents involving CFHR5

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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