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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CFHR5 Gene

protein-coding   GIFtS: 55
GCID: GC01P196946

Complement Factor H-Related 5


(Previous symbol: CFHL5)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Complement Factor H-Related 51 2     Factor H Related Protein 51
CFHL51 2 3 5     CFHR5D2
FHR52 3 5     Complement Factor H-Related Protein 52
FHR-52 3     Factor H-Related Protein 52

External Ids:    HGNC: 246681   Entrez Gene: 814942   Ensembl: ENSG000001343897   OMIM: 6085935   UniProtKB: Q9BXR63   

Export aliases for CFHR5 gene to outside databases

Previous GC identifers: GC01P195213 GC01P168103


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CFHR5 Gene:
This gene is a member of a small complement factor H (CFH) gene cluster on chromosome 1. Each member of this gene
family contains multiple short consensus repeats (SCRs) typical of regulators of complement activation. The
protein encoded by this gene has nine SCRs with the first two repeats having heparin binding properties, a region
within repeats 5-7 having heparin binding and C reactive protein binding properties, and the C-terminal repeats
being similar to a complement component 3 b (C3b) binding domain. This protein co-localizes with C3, binds C3b in
a dose-dependent manner, and is recruited to tissues damaged by C-reactive protein. Allelic variations in this
gene have been associated, but not causally linked, with two different forms of kidney disease:
membranoproliferative glomerulonephritis type II (MPGNII) and hemolytic uraemic syndrome (HUS). (provided by
RefSeq, Jan 2010)

GeneCards Summary for CFHR5 Gene: 
CFHR5 (complement factor H-related 5) is a protein-coding gene. Diseases associated with CFHR5 include membranoproliferative glomerulonephritis, and c3 glomerulonephritis. An important paralog of this gene is CSMD1.

UniProtKB/Swiss-Prot: FHR5_HUMAN, Q9BXR6
Function: Involved in complement regulation

Gene Wiki entry for CFHR5 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000001.10  NC_018912.2  NT_004487.19  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CFHR5 gene promoter:
         PPAR-gamma1   Zic1   POU3F1   PPAR-gamma2   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCFHR5 promoter sequence
   Search SABiosciences Chromatin IP Primers for CFHR5

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CFHR5


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q31.3   Ensembl cytogenetic band:  1q31.3   HGNC cytogenetic band: 1q31.3

CFHR5 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CFHR5 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P196946:  view genomic region     (about GC identifiers)

Start:
196,946,667 bp from pter      End:
196,978,804 bp from pter
Size:
32,138 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: FHR5_HUMAN, Q9BXR6 (See protein sequence)
Recommended Name: Complement factor H-related protein 5 precursor  
Size: 569 amino acids; 64419 Da
Subunit: Binds C3b in vitro
Subcellular location: Secreted
Secondary accessions: Q2NKK2

Explore the universe of human proteins at neXtProt for CFHR5: NX_Q9BXR6

Explore proteomics data for CFHR5 at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q9BXR6

  • CFHR5 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CFHR5 Protein Expression
    REFSEQ proteins: NP_110414.1  
    ENSEMBL proteins: 
     ENSP00000256785   ENSP00000356384  

    Human Recombinant Protein Products for CFHR5: 
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    Browse OriGene Protein Over-expression Lysates
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    Novus Biologicals CFHR5 Protein
    Novus Biologicals CFHR5 Lysates
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CFHR5 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region NAS11058592

    CFHR5 for ontologies           About GeneDecksing



    CFHR5 Antibody Products: 
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    Cloud-Clone Corp. CLIAs for CFHR5


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    complement: Complement system

    1 InterPro protein domain:
     IPR000436 Sushi_SCR_CCP

    Graphical View of Domain Structure for InterPro Entry Q9BXR6

    ProtoNet protein and cluster: Q9BXR6

    1 Blocks protein domain: IPB000436 Sushi domain/SCR domain/CCP module

    UniProtKB/Swiss-Prot: FHR5_HUMAN, Q9BXR6
    Similarity: Contains 9 Sushi (CCP/SCR) domains


    CFHR5 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FHR5_HUMAN, Q9BXR6
    Function: Involved in complement regulation

    Animal Models:

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CFHR5 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CFHR5

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CFHR5 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CFHR5 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CFHR5
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CFHR5:
    hsa-miR-548a-3p hsa-miR-187* hsa-miR-548e
    SwitchGear 3'UTR luciferase reporter plasmidCFHR5 3' UTR sequence
    Inhib. RNA
    Products:
        
    Browse for Gene Knock-down Tools from EMD Millipore
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    Gene Editing
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    Clone
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    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFHR5


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section




    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CFHR5

    STRING Interaction Network Preview (showing 3 interactants - click image to see more details)

    3 Interacting proteins for CFHR5 (Q9BXR63 ENSP000002567854) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C3P010243, ENSP000002459074I2D: score=2 STRING: ENSP00000245907
    MAXENSP000003514904STRING: ENSP00000351490
    MYCENSP000003672074STRING: ENSP00000367207
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006957complement activation, alternative pathway NAS11058592

    CFHR5 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CFHR5 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CFHR5 (FHR5)

    1 Novoseek inferred chemical compound relationship for CFHR5 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparin 26.1 2 15879123 (2)

    Search CenterWatch for drugs/clinical trials and news about CFHR5 / FHR5

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CFHR5 gene: 
    NM_030787.3  

    Unigene Cluster for CFHR5:

    Complement factor H-related 5
    Hs.282594  [show with all ESTs]
    Unigene Representative Sequence: NM_030787
    2 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000256785 ENST00000367414(uc001gts.4)

    miRNA
    Products:
         
    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CFHR5
    3 QIAGEN miScript miRNA Assays for microRNAs that regulate CFHR5:
    hsa-miR-548a-3p hsa-miR-187* hsa-miR-548e
    SwitchGear 3'UTR luciferase reporter plasmidCFHR5 3' UTR sequence
    Inhib. RNA
    Products:
         
    Browse for Gene Knock-down Tools from EMD Millipore
    OriGene RNAi products in human, mouse, rat for CFHR5
    QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CFHR5
    Clone
    Products:
         
    OriGene clones in human, mouse for CFHR5 (see all 6)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector: CFHR5 (NM_030787)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CFHR5
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CFHR5
    Sirion Biotech Customized lentivirus for stable overexpression of CFHR5 
                         Customized lentivirus expression plasmids for stable overexpression of CFHR5 
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CFHR5
    SABiosciences RT2 qPCR Primer Assay in human, mouse / rat CFHR5
      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CFHR5
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CFHR5

    Additional mRNA sequence: 

    AF295327.1 AK314026.1 BC026282.1 BC111773.1 

    2 DOTS entries:

    DT.91990021  DT.91743704 

    7 AceView cDNA sequences:

    BC026282 BG568555 NM_030787 BG616762 AF295327 BX951489 AV697083 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CFHR5 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: GGGAATTTTA
    CFHR5 Expression
    About this image


    See CFHR5 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CFHR5

    SOURCE GeneReport for Unigene cluster: Hs.282594

    UniProtKB/Swiss-Prot: FHR5_HUMAN, Q9BXR6
    Tissue specificity: Expressed by the liver and secreted in plasma

        SABiosciences Custom PCR Arrays for CFHR5
    Primer
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    OriGene qSTAR qPCR primer pairs in human, mouse for CFHR5
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    QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CFHR5
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFHR5

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CFHR5 gene from 3/7 species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    dog
    (Canis familiaris)
    Mammalia CFHR51 complement factor H-related 5 78.07(n)
    64.37(a)
      490262  XM_547381.4  XP_547381.3 
    zebrafish
    (Danio rerio)
    Actinopterygii CU463157.16
    cfhl36
    (see all 4)
    complement factor H like 3
    (see all 4)
    7(a)
    12(a)
    (see all 4)
    possible ortholog
    possible ortholog
    (see all 4)
    22(23247895-23276748)
    22(24118188-24131153)
    worm
    (Caenorhabditis elegans)
    Secernentea C54G4.46
    Protein C54G4.4
    6(a)
    1 → many
    I(7996728-8003179)


    ENSEMBL Gene Tree for CFHR5 (if available)
    TreeFam Gene Tree for CFHR5 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CFHR5 gene
    CSMD12  CFHR42  F13B2  CFHR22  CD462  CD552  SELP2  C4BPA2  
    CR22  CFH2  CSMD32  CR1L2  SELE2  CSMD22  APOH2  CFHR32  
    CR12  CFHR12  
    9 SIMAP similar genes for CFHR5 using alignment to 3 protein entries:     FHR5_HUMAN (see all proteins):
    CFHL1P    HF    CFHR2    CFH    CFHR1    FHR4
    CFHR3    CFHR4    CR1

    CFHR5 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/897 SNPs in CFHR5 are shown (see all 897)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0358274
    A breast cancer sample4--see VAR_0358272 N S mis40--------
    rs1113275891,2,4
    C,Funtested1203508321(+) CTGAAG/CTAGAC 2 /L /V mis13Minor allele frequency- C:0.01CSA NA EU 5819
    rs2012656641,2,4
    Cuntested1203512673(+) CGATGA/G/TCAATC 2 W C mis10--------
    rs3182407541,2,4
    Cunknown1203494051(+) ACATCC/G/TGGAAG 2 R L mis10--------
    rs358104891,2
    C--168126111(+) TATATG/ATATAT 1 -- int11Minor allele frequency- A:0.00NA 2
    rs574370381,2
    C--196949722(+) TATAC-/GTGTGTG 1 -- int10--------
    rs715675941,2
    C--196951808(+) TCTCA-/AAAAAA 1 -- int11Minor allele frequency- A:0.50NA 2
    rs1121732391,2
    F--196955869(+) TATGTG/ATGCCG 1 -- int11Minor allele frequency- A:0.50CSA 2
    rs75509701,2
    C--196956140(+) tttctC/Tcacat 1 -- int10--------
    rs75279101,2
    C--196956198(+) aactgA/Gtgtga 1 -- int10--------

    HapMap Linkage Disequilibrium report for CFHR5 (196946667 - 196978804 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10/14 variations for CFHR5 (see all 14):    About this table     
    Variant IDTypeSubtypePubMed ID
    esv2676788CNV Deletion23128226
    esv2721051CNV Deletion23290073
    nsv8702CNV Loss18304495
    nsv469599CNV Loss16826518
    nsv524689CNV Loss19592680
    nsv528460CNV Gain19592680
    dgv12e55CNV Gain17911159
    nsv471614CNV Gain+Loss15918152
    nsv428290CNV Gain+Loss18775914
    essv19099CNV CNV17122850


    Human Gene Mutation Database (HGMD): CFHR5
    SABiosciences Cancer Mutation PCR Assays
    SeqTarget long-range PCR primers for resequencing CFHR5
    DNA2.0 Custom Variant and Variant Library Synthesis for CFHR5

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 608593    OMIM disorders: --

    UniProtKB/Swiss-Prot: FHR5_HUMAN, Q9BXR6
  • Note=Defects in CFHR5 have been found in patients with atypical hemolytic uremic syndrome and may
    contribute to the disease. Atypical hemolytic uremic syndrome is a complex genetic disease characterized by
    microangiopathic hemolytic anemia, thrombocytopenia, renal failure and absence of episodes of enterocolitis and
    diarrhea. In contrast to typical hemolytic uremic syndrome, atypical forms have a poorer prognosis, with higher
    death rates and frequent progression to end-stage renal disease. Susceptibility to the development of atypical
    hemolytic uremic syndrome can be conferred by mutations in various components of or regulatory factors in the
    complement cascade system. Other genes may play a role in modifying the phenotype
  • CFHR5 deficiency (CFHR5D) [MIM:614809]: A progressive disease characterized by glomerulonephritis,
    hematuria, renal failure, end-stage renal disease, subendothelial and mesangial glomerular C3 deposits, mesangial
    matrix expansion, increased glomerular cellularity, and segmental capillary wall thickening. Hematuria may become
    apparent after respiratory infections. Note=The disease is caused by mutations affecting the gene represented in
    this entry

  • 19 diseases for CFHR5:    About MalaCards
    membranoproliferative glomerulonephritis    c3 glomerulonephritis    cfhr5-related dense deposit disease / membranoproliferative glomerulonephritis type ii    glomerulonephritis
    kuhnt-junius degeneration    hemolytic-uremic syndrome    atypical hemolytic-uremic syndrome    age related macular degeneration
    kidney disease    macular degeneration    otitis media    diarrhea
    hemolytic anemia    thrombocytopenia    hodgkin's lymphoma    non-hodgkin lymphoma
    hepatitis b    anemia    hepatitis

    1 disease from the University of Copenhagen DISEASES database for CFHR5:
    Alport syndrome

    CFHR5 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014
    GeneTests: CFHR5
    GeneReviews: CFHR5
    Genetic Association Database (GAD): CFHR5
    Human Genome Epidemiology (HuGE) Navigator: CFHR5 (9 documents)

    Export disorders for CFHR5 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CFHR5 gene, integrated from 9 sources (see all 30):
    (articles sorted by number of sources associating them with CFHR5)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Human factor H-related protein 5 (FHR-5). A new complement-associated protein. (PubMed id 11058592)1, 2, 3, 9 McRae J.L.... Murphy B.F. (2001)
    2. Mutations in alternative pathway complement proteins in American patients with atypical hemolytic uremic syndrome. (PubMed id 20513133)1, 2, 4, 9 Maga T.K....Smith R.J. (2010)
    3. Identification of a mutation in complement factor H-r elated protein 5 in patients of Cypriot origin with glomerulonephritis. (PubMed id 20800271)1, 2, 4 Gale D.P....Pickering M.C. (2010)
    4. Genetic analysis of complement factor H related 5, CFHR5, in patients with age-related macular degeneration. (PubMed id 19365580)1, 4, 9 Narendra U....Hagstrom S.A. (2009)
    5. Genetic analysis of the complement factor H related 5 gene in haemolytic uraemic syndrome. (PubMed id 17000000)1, 4, 9 Monteferrante G....Noris M. (2007)
    6. Atypical hemolytic uremic syndrome and genetic aberrations in the complement factor H-related 5 gene. (PubMed id 22622361)1, 2 Westra D.... van den Heuvel L.P. (2012)
    7. Epidemiological approach to identifying genetic predi spositions for atypical hemolytic uremic syndrome. (PubMed id 20059470)1, 4 Sullivan M....Neumann H.P. (2010)
    8. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. (PubMed id 19344414)1, 4 Cerhan J.R....Slager S.L. (2009)
    9. The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration. (PubMed id 18541031)1, 4 Zhang H....Deangelis M.M. (2008)
    10. Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications. (PubMed id 17438673)1, 4 Hageman G.S....Dean M. (2006)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 81494 HGNC: 24668 AceView: CFHL5 Ensembl:ENSG00000134389 euGenes: HUgn81494
    ECgene: CFHR5 H-InvDB: CFHR5

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CFHR5 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CFHR5 gene:
    Search GeneIP for patents involving CFHR5

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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