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CFHR3 Gene

protein-coding   GIFtS: 49
GCID: GC01P196743

Complement Factor H-Related 3


(Previous symbol: CFHL3)
  See CFHR3-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Complement Factor H-Related 31 2     H Factor-Like Protein 32 3
CFHL31 2 3 5     HLF42 5
FHR32 3 5     Complement Factor H Related 31
DOWN162 3     Complement Factor H-Related Protein 32
FHR-32 3     H Factor-Like 42

External Ids:    HGNC: 169801   Entrez Gene: 108782   Ensembl: ENSG000001167857   OMIM: 6053365   UniProtKB: Q029853   

Export aliases for CFHR3 gene to outside databases

Previous GC identifer: GC01P195011


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CFHR3 Gene:
The protein encoded by this gene is a secreted protein, which belongs to the complement factor H-related protein
family. It binds to heparin, and may be involved in complement regulation. Mutations in this gene are associated
with decreased risk of age-related macular degeneration, and with an increased risk of atypical hemolytic-uremic
syndrome. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
(provided by RefSeq, Oct 2011)

GeneCards Summary for CFHR3 Gene:
CFHR3 (complement factor H-related 3) is a protein-coding gene. Diseases associated with CFHR3 include macular degeneration, age-related, reduced risk of, and cfhr3 and cfhr1-related atypical hemolytic-uremic syndrome. An important paralog of this gene is CFHR4.

UniProtKB/Swiss-Prot: FHR3_HUMAN, Q02985
Function: Might be involved in complement regulation

Gene Wiki entry for CFHR3 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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Regulatory elements:
   Regulatory transcription factor binding sites in the CFHR3 gene promoter:
         COUP-TF1   COUP   HNF-4alpha2   YY1   HNF-4alpha1   Evi-1   C/EBPalpha   COUP-TF   Msx-1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCFHR3 promoter sequence
   Search Chromatin IP Primers for CFHR3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CFHR3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q31.3   HGNC cytogenetic band: 1q32

CFHR3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CFHR3 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P196743:  view genomic region     (about GC identifiers)

Start:
196,743,925 bp from pter      End:
196,763,203 bp from pter
Size:
19,279 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: FHR3_HUMAN, Q02985 (See protein sequence)
Recommended Name: Complement factor H-related protein 3 precursor  
Size: 330 amino acids; 37323 Da
Secondary accessions: B4DPR0 Q9UJ16
Alternative splicing: 2 isoforms:  Q02985-1   Q02985-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CFHR3: NX_Q02985

Explore proteomics data for CFHR3 at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn108, Asn185, Asn205, Asn309

  • See CFHR3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_001160096.1  NP_066303.2  

    ENSEMBL proteins: 
     ENSP00000356395   ENSP00000436258   ENSP00000356397   ENSP00000375845  
    Reactome Protein details: Q02985

    CFHR3 Human Recombinant Protein Products:

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    CFHR3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    complement: Complement system

    1 InterPro protein domain:
     IPR000436 Sushi_SCR_CCP

    Graphical View of Domain Structure for InterPro Entry Q02985

    ProtoNet protein and cluster: Q02985

    1 Blocks protein domain: IPB000436 Sushi domain/SCR domain/CCP module

    UniProtKB/Swiss-Prot: FHR3_HUMAN, Q02985
    Similarity: Contains 5 Sushi (CCP/SCR) domains


    Find genes that share domains with CFHR3           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FHR3_HUMAN, Q02985
    Function: Might be involved in complement regulation

    Phenotypes:
         1 GenomeRNAi human phenotype for CFHR3:

     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CFHR3
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CFHR3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CFHR3

    miRNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CFHR3

    Gene Editing
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    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CFHR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CFHR3

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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFHR3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FHR3_HUMAN, Q02985: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS8428964
    GO:0072562blood microparticle IDA--

    Find genes that share ontologies with CFHR3           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CFHR3 About    
    See pathways by source

    SuperPathContained pathways About
    1Creation of C4 and C2 activators
    Complement cascade0.68
    2Complement Pathway
    Regulation of Complement cascade0.48


    Find genes that share SuperPaths with CFHR3           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 Reactome Pathway for CFHR3
        Regulation of Complement cascade


        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CFHR3
    Interactions:

        Search GeneGlobe Interaction Network for CFHR3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

    Selected Interacting proteins for CFHR3 (Q029853 ENSP000003563954) via UniProtKB, MINT, STRING, and/or I2D (see all 8)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    C3P010243, ENSP000002459074I2D: score=2 STRING: ENSP00000245907
    ENSG00000236342ENSP000004125534STRING: ENSP00000412553
    IVNS1ABPENSP000003564684STRING: ENSP00000356468
    LRRC18ENSP000002981244STRING: ENSP00000298124
    PRDX4ENSP000003686464STRING: ENSP00000368646
    About this table

    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CFHR3 (FHR3)



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CFHR3 gene (2 alternative transcripts): 
    NM_001166624.1  NM_021023.5  

    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000367425(uc001gtl.3 uc010poy.2) ENST00000471440(uc001gtk.3)
    ENST00000367427 ENST00000391985 ENST00000461558
    miRNA
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    Search for qRT-PCR Assays for microRNAs that regulate CFHR3
    SwitchGear 3'UTR luciferase reporter plasmidCFHR3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CFHR3
    Predesigned siRNA for gene silencing in human, mouse, rat CFHR3
    Clone
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    OriGene clones in human, mouse for CFHR3 (see all 11)
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CFHR3 (NM_021023)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CFHR3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CFHR3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CFHR3
    Search Pre-validated RT2 qPCR Primer Assays in human, mouse, rat CFHR3
      QuantiTect SYBR Green Assays in human, mouse, rat CFHR3
      QuantiFast Probe-based Assays in human, mouse, rat CFHR3

    2 AceView cDNA sequences:

    AV687102 AV684857 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CFHR3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CFHR3 Expression
    About this image


    CFHR3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     NULL (Uncategorized)
             CD31, CD144 positive cells
     
     Liver (Hepatobiliary System)
    CFHR3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CFHR3 Protein Expression

    UniProtKB/Swiss-Prot: FHR3_HUMAN, Q02985
    Tissue specificity: Expressed by the liver and secreted in plasma

        Custom PCR Arrays for CFHR3
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFHR3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CFHR3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    9(a)
    1 → many
    8(2641142-2673492)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    11(a)
    many ↔ many
    GL343432.1(1543-71625)
    zebrafish
    (Danio rerio)
    Actinopterygii cfhl46
    complement factor H like 4
    16(a)
    many ↔ many
    22(24273936-24285641) ENSDARG00000094496
            Species with no ortholog for CFHR3

    ENSEMBL Gene Tree for CFHR3 (if available)
    TreeFam Gene Tree for CFHR3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CFHR3 gene
    CFHR42  F13B2  CFHR22  CFHR52  CFH2  CFHR12  
    7 SIMAP similar genes for CFHR3 using alignment to 3 protein entries:     FHR3_HUMAN (see all proteins):
    CFH    CFHR4    CFHL1P    CFHR1    CFHR2    CFHR5
    HF

    Find genes that share paralogs with CFHR3           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CFHR3
    PGOHUM00000245140 PGOHUM00000245142


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CFHR3 (see all 540)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1424838241,2
    --196742040(+) GTATCA/GTGTGT 2 -- us2k10--------
    rs1459945231,2
    --196742240(+) TTGTGA/GTTAAA 2 -- us2k10--------
    rs752822891,2
    C,F--196742291(+) ACTTGT/CAGTGC 2 -- us2k11Minor allele frequency- C:0.04EA 120
    rs1932026271,2
    C--196742347(+) TCTTAC/TATTTA 2 -- us2k10--------
    rs730735671,2
    C,F--196742439(+) TCACAT/CATTTT 2 -- us2k12Minor allele frequency- C:0.33WA CSA 3
    rs1497374461,2
    --196742505(+) TTGTAA/GCTATT 2 -- us2k10--------
    rs1850893081,2
    --196742509(+) AGCTAC/TTATTT 2 -- us2k10--------
    rs1446108421,2
    --196742549(+) TCTAAA/GTTCTA 2 -- us2k10--------
    rs109221151,2
    A--196742800(+) AAATtA/Ttatat 2 -- us2k1 tfbs30--------
    rs1422677841,2
    --196742942(+) GTATGA/CTCTAT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CFHR3 (196743925 - 196763203 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CFHR3 (see all 56):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820836CNV Deletion20802225
    dgv87e199CNV Deletion23128226
    esv2630480CNV Deletion19546169
    esv1001500CNV Deletion20482838
    esv2421560CNV Deletion20811451
    dgv88e199CNV Deletion23128226
    esv2721017CNV Deletion23290073
    dgv54e201CNV Deletion23290073
    nsv436214CNV Deletion17901297
    nsv471352CNV Duplication19718026

    Human Gene Mutation Database (HGMD): CFHR3
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CFHR3
    DNA2.0 Custom Variant and Variant Library Synthesis for CFHR3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605336   
    OMIM disorders: 603075  235400  
    5 diseases for CFHR3:    
    About MalaCards
    macular degeneration, age-related, reduced risk of    cfhr3 and cfhr1-related atypical hemolytic-uremic syndrome    atypical hemolytic-uremic syndrome    hemolytic-uremic syndrome
    age related macular degeneration

    2 diseases from the University of Copenhagen DISEASES database for CFHR3:
    hemolytic-uremic syndrome     Age related macular degeneration

    Find genes that share disorders with CFHR3           About GenesLikeMe

    Genetic Association Database (GAD): CFHR3
    Human Genome Epidemiology (HuGE) Navigator: CFHR3 (11 documents)

    Export disorders for CFHR3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CFHR3 gene, integrated from 10 sources (see all 42):
    (articles sorted by number of sources associating them with CFHR3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. A novel short consensus repeat-containing molecule is related to human complement factor H. (PubMed id 8428964)1, 2, 3, 9 Skerka C.... Zipfel P.F. (J. Biol. Chem. 1993)
    2. Contribution of copy number variation in the regulation of complement activation locus to development of age-related macular degeneration. (PubMed id 19553609)1, 4, 9 Schmid-Kubista K.E....Edwards A.O. (amp 2009)
    3. Complement factor h autoantibodies and age-related macular degeneration. (PubMed id 20592223)1, 4 Dhillon B....Marchbank K.J. (amp 2010)
    4. Associations of CFHR1-CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent. (PubMed id 20581873)1, 4 Raychaudhuri S....Daly M.J. (Nat. Genet. 2010)
    5. Epidemiological approach to identifying genetic predispositions for atypical hemolytic uremic syndrome. (PubMed id 20059470)1, 4 Sullivan M....Neumann H.P. (Ann. Hum. Genet. 2010)
    6. Genome-wide association study identifies variants in the CFH region associated with host susceptibility to meningococcal disease. (PubMed id 20694013)1, 4 Davila S....Hibberd M.L. (Nat. Genet. 2010)
    7. Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration. (PubMed id 18084039)1, 4 Spencer K.L....Haines J.L. (Hum. Mol. Genet. 2008)
    8. Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications. (PubMed id 17438673)1, 4 Hageman G.S....Dean M. (Ann. Med. 2006)
    9. The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (Nature 2006)
    10. A common CFH haplotype, with deletion of CFHR1 and CFHR3, is associated with lower risk of age-related macular degeneration. (PubMed id 16998489)1, 4 Hughes A.E....Chakravarthy U. (Nat. Genet. 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 10878 HGNC: 16980 AceView: CFHL3 Ensembl:ENSG00000116785 euGenes: HUgn10878
    ECgene: CFHR3 H-InvDB: CFHR3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CFHR3 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CFHR3 gene:
    Search GeneIP for patents involving CFHR3

    GeneCards and IP:
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    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
    Advanced Cell Diagnostics, Animal models from inGenious Targeting Laboratory, genOway)
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     Browse OriGene Antibodies   OriGene RNAi products in human, mouse, rat for CFHR3  
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     Block miRNA regulation of human, mouse, rat CFHR3 using miScript Target Protectors SeqTarget long-range PCR primers for resequencing CFHR3
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