CFHR2 Gene
protein-coding GIFtS: 50
GCID: GC01P196789
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complement factor H-related 2(Previous name: H factor (complement)-like 3 )
(Previous symbols: HFL3, CFHL2)
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Aliases
for CFHR2 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Complement Factor H-Related 21 2 | | H Factor-Like Protein 22 3 | | CFHL21 2 3 5 | | DDESK592 3 | | FHR21 2 3 5 | | FHR-22 3 | | HFL31 2 3 5 | | Complement Factor H-Related Protein 22 | | H Factor (Complement)-Like 31 2 | | Factor H-Related Gene 22 | | H Factor-Like 32 3 | | |
Export aliases for CFHR2 gene to outside databasesPrevious GC identifers: GC01P195179 GC01P168070 |
Summaries
for CFHR2 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
UniProtKB/Swiss-Prot: FHR2_HUMAN, P36980Function: Might be involved in complement regulation. Can associate with lipoproteins and may play a role in lipidmetabolism
Gene Wiki entry for CFHR2
|
Genomic Views
for CFHR2 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000001.10 NC_018912.1 NT_004487.19
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CFHR2 gene promoter:
MEF-2A NF-AT4 NF-AT2 Zic1 NF-AT3 aMEF-2 NF-AT1 NF-AT
Other transcription factors
Search SABiosciences Chromatin IP Primers for CFHR2
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CFHR2 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 1q31.3 Ensembl cytogenetic band: 1q31.3 HGNC cytogenetic band: 1q31.3CFHR2 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 1 GeneLoc Exon Structure GeneLoc location for GC01P196789: view genomic region
(about GC identifiers)
Start:
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196,788,898 bp from pter |
End:
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196,928,356 bp from pter |
Size:
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139,459 bases |
Orientation:
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plus strand |
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Proteins
for CFHR2 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: FHR2_HUMAN, P36980 (See
protein sequence)Recommended Name: Complement factor H-related protein 2 precursor Size: 270 amino acids; 30651 Da
Subcellular location: Secreted
Secondary accessions: Q14310 Q5T9T1Alternative splicing: 2 isoforms: P36980-1 P36980-2 (No experimental confirmation available)Explore the universe of human proteins at neXtProt for CFHR2: NX_P36980
Post-translational modifications:
N-glycosylated1
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_P36980
CFHR2 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_005657.1
ENSEMBL proteins: ENSP00000356385 ENSP00000356391
Human Recombinant Protein Products:
Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table | GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|
| GO:0005576 | extracellular region |
IEA | -- |
CFHR2 for ontologies About GeneDecksing
CFHR2 Antibody Products:
Assay Products for CFHR2: |
Protein
Domains /
Families
for CFHR2 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CFHR2 for domains About GeneDecksing
1 InterPro domain/family:Graphical View of Domain Structure for InterPro Entry P36980ProtoNet protein and cluster: P36980 1 Blocks protein family: IPB000436 Sushi domain/SCR domain/CCP module
UniProtKB/Swiss-Prot: FHR2_HUMAN, P36980Similarity: Contains 4 Sushi (CCP/SCR) domains |
Function
for CFHR2 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: FHR2_HUMAN, P36980Function: Might be involved in complement regulation. Can associate with lipoproteins and may play a role in lipidmetabolism
Clone
Products: |  | Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore | |  | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CFHR2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CFHR2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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1 GenomeRNAi human phenotype for CFHR2:
|
Pathways & Interactions
for CFHR2 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CFHR2
STRING Interaction
Network Preview (showing 1 interactants - click image to see more details)
2 Interacting proteins for CFHR2 (P369803 ENSP000003563854) via UniProtKB, MINT, STRING, and/or I2DAbout this table
|
Drugs & Compounds
for CFHR2 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
CFHR2 for compounds About GeneDecksing
 Browse Tocris compounds for CFHR2
1 Novoseek chemical compound relationship for CFHR2 gene About this table
| Compound |
-log (P-Val) |
Hits |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| heparin |
34.8 |
1 |
10408366 (1) |
Search CenterWatch for drugs/clinical trials and news about CFHR2 / FHR2
|
Transcripts
for CFHR2 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CFHR2 gene: NM_005666.2 Unigene Cluster for CFHR2: Complement factor H-related 2 Hs.632450 [show with all ESTs]Unigene Representative Sequence: BG5679987 Ensembl transcripts including schematic representations, and UCSC links where relevant: ENST00000367415(uc001gtq.1 uc001gtr.1) ENST00000485647 ENST00000476712
ENST00000489703 ENST00000496448 ENST00000473386 ENST00000367421
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CFHR2
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CFHR2 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CFHR2 (NM_005666) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CFHR2 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CFHR2 |
Additional cDNA sequence: BC022283.1 X64877.1 9 DOTS entries: DT.452545 DT.92463750 DT.95211982 DT.100828430 DT.92463769 DT.92463783 DT.121361166 DT.92463758 DT.92463773 24/74 AceView cDNA sequences (see all 74): AX772812 AV681761 CB122245 CB123026 AV681564 BG562869 AV681655 BG533248 BG563181 AV688058 BG618672 BG567040 BG564330 BG566607 AV683459 BG616866 CB157665 BG565462 BG563738 BG564962 T67925 BG617178 X64877 AV685061
GeneLoc Exon Structure
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Expression
for CFHR2 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CFHR2 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTAATATCA
About this image
See CFHR2 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CFHR2
SOURCE GeneReport for Unigene cluster: Hs.632450
UniProtKB/Swiss-Prot: FHR2_HUMAN, P36980Tissue specificity: Expressed by the liver and secreted in plasma
SABiosciences Custom PCR Arrays for CFHR2
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CFHR2
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CFHR2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CFHR2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CFHR2 |
Orthologs
for CFHR2 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of animals.
Orthologs for CFHR2 gene from 4/12 species (see all 12) About this table
ENSEMBL Gene Tree for CFHR2 (if available)
TreeFam Gene Tree for CFHR2 (if available) |
Paralogs
for CFHR2 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CFHR2 gene
- F13B2 CFHR42 APOH2 CFHR52 CFH2 CFHR32 CFHR12
7 SIMAP similar genes for CFHR2 using alignment to 1 protein entry: FHR2_HUMAN:CFHR1 CFH CFHR5 HF CFHR3 CFHR4
FHR4
CFHR2 for paralogs About GeneDecksing
|
Genomic Variants
for CFHR2 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 1 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CFHR2 (196788898 - 196928356 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 16 variations for CFHR2
15/16 CNVs (see all 16): 34422 84768 43700 30449 70901 31680 3325 34583 34751 74846 2343 53979 8343 53605 2055
Human Gene Mutation Database (HGMD): CFHR2
| SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CFHR2 |
|
Disorders
/ Diseases
for CFHR2 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CFHR2 for disorders About GeneDecksing
OMIM gene information: 600889
OMIM disorders: --
7  diseases for CFHR2: About MalaCardskuhnt-junius degeneration hemolytic-uremic syndrome atypical hemolytic-uremic syndrome age related macular degeneration
macular degeneration hepatitis b hepatitis
Human Genome Epidemiology (HuGE) Navigator: CFHR2 (4 documents)
Export disorders for CFHR2 gene to outside databases
|
Publications
for CFHR2 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CFHR2 gene, integrated from 9 sources (see all 18):
(articles sorted by number of sources associating them with CFHR2) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- The human factor H-related gene 2 (FHR2): structure and linkage to the coagulation factor XIIIb gene. (PubMed id 7672821)1, 2, 3, 9 Skerka C.... Zipfel P.F. (1995)
- Two additional human serum proteins structurally related to complement factor H. Evidence for a family of factor H-related genes. (PubMed id 1533657)1, 2, 3 Skerka C.... Zipfel P.E. (1992)
- The DNA sequence and biological annotation of human chromosome 1. (PubMed id 16710414)1, 2 Gregory S.G.... Bentley D.R. (2006)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Complement factor H and related proteins: an expanding family of complement-regulatory proteins? (PubMed id 8172644)1, 2 Zipfel P.F. and Skerka C. (1994)
- Interactions of pathological hallmark proteins: tubul in polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PubMed id 21832049)1 OlA!h J....OvA!di J. (2011)
- New genetic associations detected in a host response study to hepatitis B vaccine. (PubMed id 20237496)1 Davila S....Seielstad M. (2010)
- Epidemiological approach to identifying genetic predi spositions for atypical hemolytic uremic syndrome. (PubMed id 20059470)1 Sullivan M....Neumann H.P. (2010)
- Glycoproteomics analysis of human liver tissue by combination of multiple enzyme digestion and hydrazide chemistry. (PubMed id 19159218)2 Chen R.... Zou H. (2009)
- The NEI/NCBI dbGAP database: genotypes and haplotypes that may specifically predispose to risk of neovascular age-related macular degeneration. (PubMed id 18541031)1 Zhang H....Deangelis M.M. (2008)
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External Searches for CFHR2 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CFHR2 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CFHR2 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CFHR2 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
| Name | Description |
| PharmGKB entry for CFHR2 | Pharmacogenomics, SNPs, Pathways |
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| | |
About This Section
| Patent Information for CFHR2 gene:
Search GeneIP for patents involving CFHR2
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CFHR2 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
| | |  | Browse OriGene Antibodies | | OriGene shRNA RFP for CFHR2 | | | OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CFHR2 | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CFHR2 | | | OriGene Protein Over-expression Lysate for CFHR2 | | Browse OriGene Fluorogenic Cell Assay Kits | | | OriGene siRNA for CFHR2 | | OriGene 3'-UTR Clone for CFHR2 | | | OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CFHR2 | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CFHR2 | | | Browse OriGene GFP tagged cDNA clones in CMV expression vector | | Browse OriGene MicroRNA Expression Plasmids | | | Browse OriGene basic RS shRNAs | | Browse OriGene validated miRNA SYBR primer pairs | | | Browse OriGene full length recombinant human proteins expressed in human HEK293 cells | | OriGene custom cloning services - gene synthesis, subcloning, mutagenesis,
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CFHR2 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CFHR2 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CFHR2 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CFHR2 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CFHR2 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CFHR2 |
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 | | | CFHR2 Proteins, Antibodies, CLIAs, and ELISAs |
| | | |  |  |  | | | | Search ThermoFisher Antibodies for CFHR2 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CFHR2 |
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