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Aliases for CFHR2 Gene

Aliases for CFHR2 Gene

  • Complement Factor H-Related 2 2 3
  • CFHL2 3 4 6
  • HFL3 3 4 6
  • FHR2 3 4 6
  • H Factor (Complement)-Like 3 2 3
  • H Factor-Like Protein 2 3 4
  • H Factor-Like 3 3 4
  • DDESK59 3 4
  • FHR-2 3 4
  • Complement Factor H-Related Protein 2 3
  • Factor H-Related Gene 2 3

External Ids for CFHR2 Gene

Previous HGNC Symbols for CFHR2 Gene

  • HFL3
  • CFHL2

Previous GeneCards Identifiers for CFHR2 Gene

  • GC01P195179
  • GC01P196789
  • GC01P168070

Summaries for CFHR2 Gene

GeneCards Summary for CFHR2 Gene

CFHR2 (Complement Factor H-Related 2) is a Protein Coding gene. Diseases associated with CFHR2 include dense deposit disease. An important paralog of this gene is F13B.

UniProtKB/Swiss-Prot for CFHR2 Gene

  • Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.

Gene Wiki entry for CFHR2 Gene

No data available for Entrez Gene Summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFHR2 Gene

Genomics for CFHR2 Gene

Regulatory Elements for CFHR2 Gene

Genomic Location for CFHR2 Gene

Start:
196,943,759 bp from pter
End:
196,959,226 bp from pter
Size:
15,468 bases
Orientation:
Plus strand

Genomic View for CFHR2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CFHR2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFHR2 Gene

Proteins for CFHR2 Gene

  • Protein details for CFHR2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P36980-FHR2_HUMAN
    Recommended name:
    Complement factor H-related protein 2
    Protein Accession:
    P36980
    Secondary Accessions:
    • Q14310
    • Q5T9T1

    Protein attributes for CFHR2 Gene

    Size:
    270 amino acids
    Molecular mass:
    30651 Da
    Quaternary structure:
    • Head-to-tail homodimer and heterodimer with CFHR1 or CFHR5.

    Three dimensional structures from OCA and Proteopedia for CFHR2 Gene

    Alternative splice isoforms for CFHR2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CFHR2 Gene

Proteomics data for CFHR2 Gene at MOPED

Post-translational modifications for CFHR2 Gene

Other Protein References for CFHR2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • R&D Systems Antibodies for CFHR2 (Complement Factor H-related 2/CFHR2)
  • Santa Cruz Biotechnology (SCBT) Antibodies for CFHR2

No data available for DME Specific Peptides for CFHR2 Gene

Domains for CFHR2 Gene

Gene Families for CFHR2 Gene

HGNC:

Protein Domains for CFHR2 Gene

Suggested Antigen Peptide Sequences for CFHR2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P36980

UniProtKB/Swiss-Prot:

FHR2_HUMAN :
  • P36980
Domain:
  • Contains 4 Sushi (CCP/SCR) domains.
genes like me logo Genes that share domains with CFHR2: view

Function for CFHR2 Gene

Molecular function for CFHR2 Gene

UniProtKB/Swiss-Prot Function: Involved in complement regulation. The dimerized forms have avidity for tissue-bound complement fragments and efficiently compete with the physiological complement inhibitor CFH. Can associate with lipoproteins and may play a role in lipid metabolism.

Phenotypes for CFHR2 Gene

genes like me logo Genes that share phenotypes with CFHR2: view

Animal Model Products

CRISPR Products

miRNA for CFHR2 Gene

miRTarBase miRNAs that target CFHR2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , Transcription Factor Targeting and HOMER Transcription for CFHR2 Gene

Localization for CFHR2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFHR2 Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CFHR2 Gene COMPARTMENTS Subcellular localization image for CFHR2 gene
Compartment Confidence
extracellular 5
lysosome 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CFHR2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CFHR2: view

Pathways for CFHR2 Gene

SuperPathways for CFHR2 Gene

No Data Available

Interacting Proteins for CFHR2 Gene

Selected Interacting proteins: P36980-FHR2_HUMAN for CFHR2 Gene via I2D

Symbol External ID(s) Details
ATG12

Gene Ontology (GO) - Biological Process for CFHR2 Gene

None

No data available for Pathways by source for CFHR2 Gene

Compounds for CFHR2 Gene

(1) Novoseek inferred chemical compound relationships for CFHR2 Gene

Compound -log(P) Hits PubMed IDs
heparin 34.8 1
genes like me logo Genes that share compounds with CFHR2: view

Transcripts for CFHR2 Gene

Unigene Clusters for CFHR2 Gene

Complement factor H-related 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CFHR2

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CFHR2 Gene

No ASD Table

Relevant External Links for CFHR2 Gene

GeneLoc Exon Structure for
CFHR2
ECgene alternative splicing isoforms for
CFHR2

Expression for CFHR2 Gene

mRNA expression in normal human tissues for CFHR2 Gene

mRNA differential expression in normal tissues according to GTEx for CFHR2 Gene

This gene is overexpressed in Liver (52.8).

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CFHR2 Gene

SOURCE GeneReport for Unigene cluster for CFHR2 Gene Hs.632450

mRNA Expression by UniProt/SwissProt for CFHR2 Gene

P36980-FHR2_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma
genes like me logo Genes that share expressions with CFHR2: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery for CFHR2 Gene

Orthologs for CFHR2 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CFHR2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CFHR2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CFHR2 35
  • 73.84 (n)
  • 62.15 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 9 (a)
OneToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 21 (a)
ManyToMany
chicken
(Gallus gallus)
Aves -- 36
  • 8 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 4 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii cfh 36
  • 8 (a)
ManyToMany
Species with no ortholog for CFHR2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFHR2 Gene

ENSEMBL:
Gene Tree for CFHR2 (if available)
TreeFam:
Gene Tree for CFHR2 (if available)

Paralogs for CFHR2 Gene

Paralogs for CFHR2 Gene

Selected SIMAP similar genes for CFHR2 Gene using alignment to 2 proteins:

genes like me logo Genes that share paralogs with CFHR2: view

Variants for CFHR2 Gene

Sequence variations from dbSNP and Humsavar for CFHR2 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs400091 -- 196,943,057(-) TGTTC(C/T)GATGG upstream-variant-2KB
rs431535 -- 196,943,084(-) TGAAC(A/C)AATTT upstream-variant-2KB
rs432366 -- 196,943,061(-) ATTTT(C/G)TTCCG upstream-variant-2KB
rs447019 -- 196,943,071(-) CTTCA(A/G)AATAA upstream-variant-2KB
rs1359593 -- 196,953,978(+) TTCAT(A/T)TACAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CFHR2 Gene

Variant ID Type Subtype PubMed ID
nsv528460 CNV Gain 19592680
nsv428290 CNV Gain+Loss 18775914
esv743 CNV CNV 17122850
nsv471614 CNV Gain+Loss 15918152
dgv166e1 CNV Complex 17122850
dgv168e1 CNV Complex 17122850
esv26552 CNV Gain+Loss 19812545
nsv8691 CNV Gain+Loss 18304495
dgv500n71 CNV Loss 21882294
dgv501n71 CNV Gain+Loss 21882294
nsv517662 CNV Gain+Loss 19592680
nsv3999 CNV Loss 18451855
dgv12e55 CNV Gain 17911159
essv8557 CNV CNV 17122850
dgv506n71 CNV Gain 21882294
dgv507n71 CNV Gain+Loss 21882294
dgv508n71 CNV Loss 21882294
esv5113 CNV Deletion 18987735
nsv469599 CNV Loss 16826518
dgv171e1 CNV Complex 17122850
dgv511n71 CNV Gain+Loss 21882294
dgv512n71 CNV Gain+Loss 21882294
nsv873060 CNV Loss 21882294
nsv470770 CNV Loss 18288195
dgv57n27 CNV Loss 19166990
dgv58n27 CNV Gain 19166990
essv21109 CNV CNV 17122850
nsv873062 CNV Gain 21882294
nsv826042 CNV Gain 20364138

Relevant External Links for CFHR2 Gene

HapMap Linkage Disequilibrium report
CFHR2
Human Gene Mutation Database (HGMD)
CFHR2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CFHR2 Gene

Disorders for CFHR2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CFHR2 Gene including...

Search for CFHR2 Gene in MalaCards »

Relevant External Links for CFHR2

Genetic Association Database (GAD)
CFHR2
Human Genome Epidemiology (HuGE) Navigator
CFHR2
genes like me logo Genes that share disorders with CFHR2: view

No data available for UniProtKB/Swiss-Prot for CFHR2 Gene

Publications for CFHR2 Gene

  1. The human factor H-related gene 2 (FHR2): structure and linkage to the coagulation factor XIIIb gene. (PMID: 7672821) Skerka C. … Zipfel P.F. (Immunogenetics 1995) 2 3 4 23
  2. Two additional human serum proteins structurally related to complement factor H. Evidence for a family of factor H-related genes. (PMID: 1533657) Skerka C. … Zipfel P.E. (J. Immunol. 1992) 2 3 4
  3. Complement factor H and related proteins: an expanding family of complement-regulatory proteins? (PMID: 8172644) Zipfel P.F. … Skerka C. (Immunol. Today 1994) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. The DNA sequence and biological annotation of human chromosome 1. (PMID: 16710414) Gregory S.G. … Bentley D.R. (Nature 2006) 3 4

Products for CFHR2 Gene

Sources for CFHR2 Gene

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