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CFHR1 Gene

protein-coding   GIFtS: 51
GCID: GC01P196788

Complement Factor H-Related 1

(Previous names: H factor (complement)-like 1, complement factor H-related...)
(Previous symbols: HFL1, CFHL1, CFHR1P, HFL2, CFHL1P)
Pneumococci & Pneumococcal Diseases Congress
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Complement Factor H-Related 11 2     H Factor (Complement)-Like 21 2
CFHL11 2 3 5     H Factor-Like Protein 12 3
HFL11 2 3 5     CFHL2 3
CFHL1P1 2 3     FHR-12 3
CFHR1P1 2 3     H362 3
HFL21 2 3     H-Factor-Like 12 3
FHR12 3 5     H36-12
Complement Factor H-Related 1 Pseudogene1 2     H36-22
H Factor (Complement)-Like 11 2     Complement Factor H-Related Protein 12

External Ids:    HGNC: 48881   Entrez Gene: 30782   Ensembl: ENSG000002444147   OMIM: 1343715   UniProtKB: Q035913   

Export aliases for CFHR1 gene to outside databases

Previous GC identifer: GC01P195056


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CFHR1 Gene:
This gene encodes a secreted protein belonging to the complement factor H protein family. It binds to Pseudomonas
aeruginosa elongation factor Tuf together with plasminogen, which is proteolytically activated. It is proposed
that Tuf acts as a virulence factor by acquiring host proteins to the pathogen surface, controlling complement,
and facilitating tissue invasion. Mutations in this gene are associated with an increased risk of atypical
hemolytic-uremic syndrome. (provided by RefSeq, Oct 2009)

GeneCards Summary for CFHR1 Gene:
CFHR1 (complement factor H-related 1) is a protein-coding gene. Diseases associated with CFHR1 include atypical hemolytic-uremic syndrome, and complement factor h deficiency. An important paralog of this gene is CFHR4.

UniProtKB/Swiss-Prot: FHR1_HUMAN, Q03591
Function: Might be involved in complement regulation. Can associate with lipoproteins and may play a role in lipid
metabolism

Gene Wiki entry for CFHR1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000001.11  NT_004487.20  NC_018912.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CFHR1 gene promoter:
         MEF-2A   Pax-6   Zic1   aMEF-2   NF-kappaB   NF-kappaB1   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCFHR1 promoter sequence
   Search Chromatin IP Primers for CFHR1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CFHR1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 1q32   Ensembl cytogenetic band:  1q31.3   HGNC cytogenetic band: 1q32

CFHR1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CFHR1 gene location

GeneLoc information about chromosome 1         GeneLoc Exon Structure

GeneLoc location for GC01P196788:  view genomic region     (about GC identifiers)

Start:
196,788,861 bp from pter      End:
196,801,319 bp from pter
Size:
12,459 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: FHR1_HUMAN, Q03591 (See protein sequence)
Recommended Name: Complement factor H-related protein 1 precursor  
Size: 330 amino acids; 37651 Da
1 PDB 3D structure from and Proteopedia for CFHR1:
3ZD2 (3D)    
Secondary accessions: A8K465 Q3B774 Q9UJ17

Explore the universe of human proteins at neXtProt for CFHR1: NX_Q03591

Explore proteomics data for CFHR1 at MOPED

Post-translational modifications: 

  • N-glycosylated. Two forms are observed; one with a single side chain and the other with two1
  • Glycosylation2 at Asn126, Asn194

  • See CFHR1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_002104.2  
    ENSEMBL proteins: 
     ENSP00000314299   ENSP00000356394  

    CFHR1 Human Recombinant Protein Products:

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    CFHR1 Assay Products:

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    Cloud-Clone Corp. CLIAs for CFHR1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    complement: Complement system

    1 InterPro protein domain:
     IPR000436 Sushi_SCR_CCP

    Graphical View of Domain Structure for InterPro Entry Q03591

    ProtoNet protein and cluster: Q03591

    1 Blocks protein domain: IPB000436 Sushi domain/SCR domain/CCP module

    UniProtKB/Swiss-Prot: FHR1_HUMAN, Q03591
    Similarity: Contains 5 Sushi (CCP/SCR) domains


    CFHR1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: FHR1_HUMAN, Q03591
    Function: Might be involved in complement regulation. Can associate with lipoproteins and may play a role in lipid
    metabolism

    Phenotypes:
         1 GenomeRNAi human phenotype for CFHR1:

     Decreased viability with pacli 

    Animal Models:
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    1 qRT-PCR Assays for microRNA that regulate CFHR1:
    hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidCFHR1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CFHR1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    FHR1_HUMAN, Q03591: Secreted
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005615extracellular space TAS1711047
    GO:0072562blood microparticle IDA--

    CFHR1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CFHR1
    Interactions:

        Search GeneGlobe Interaction Network for CFHR1

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5 Interacting proteins for CFHR1 (Q035913 ENSP000003142994) via UniProtKB, MINT, STRING, and/or I2D
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LBPP184283, ENSP000002174074I2D: score=3 STRING: ENSP00000217407
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    CFHP086033, ENSP000003563994I2D: score=1 STRING: ENSP00000356399
    C3ENSP000002459074STRING: ENSP00000245907
    PRDX4ENSP000003686464STRING: ENSP00000368646
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006956complement activation TAS1711047

    CFHR1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CFHR1 (FHR1)

    1 Novoseek inferred chemical compound relationship for CFHR1 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    heparin 35.6 2 10408366 (2)



    CFHR1 for compounds           About GeneDecksing



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CFHR1 gene: 
    NM_002113.2  

    Unigene Cluster for CFHR1:

    Complement factor H-related 1
    Hs.575869  [show with all ESTs]
    Unigene Representative Sequence: BC107771
    5 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000320493(uc001gtm.3 uc001gtn.3) ENST00000367424 ENST00000472961
    ENST00000468079 ENST00000480960

    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CFHR1:
    hsa-miR-3658
    SwitchGear 3'UTR luciferase reporter plasmidCFHR1 3' UTR sequence
    Inhib. RNA
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    OriGene RNAi products in human, mouse, rat for CFHR1
    Predesigned siRNA for gene silencing in human, mouse, rat CFHR1
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    Primer
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    OriGene qPCR primer pairs and template standards for CFHR1
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      QuantiTect SYBR Green Assays in human, mouse, rat CFHR1
      QuantiFast Probe-based Assays in human, mouse, rat CFHR1

    Additional mRNA sequence: 

    AK290830.1 AK311681.1 BC016755.1 BC107771.1 M65292.1 M65293.1 X56209.1 

    14 DOTS entries:

    DT.92463758  DT.95211965  DT.100828430  DT.92463766  DT.100828418  DT.100828424  DT.100828432  DT.95211960 
    DT.452545  DT.95211955  DT.95211982  DT.100828419  DT.121361166  DT.95212008 

    Selected AceView cDNA sequences (see all 361):

    CB111909 BF063270 R29067 BQ004158 BM842566 BX955865 BQ008669 AV682851 
    R29055 C02409 BQ183146 BM968817 CR598844 AU117056 BG617334 CR601432 
    Y00716 AI683097 CB164041 AV700023 BC016755 BX952698 BE349130 CA391822 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CFHR1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CFHR1 Expression
    About this image

    CFHR1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CFHR1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.575869

    UniProtKB/Swiss-Prot: FHR1_HUMAN, Q03591
    Tissue specificity: Expressed by the liver and secreted in plasma

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFHR1

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CFHR1 gene from Selected species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cfhr11 , 5 complement factor H-related 11, 5 68.5(n)1
    59.94(a)1
      1 (61.62 cM)5
    507021  NM_015780.21  NP_056595.11 
     1395470625 
    chicken
    (Gallus gallus)
    Aves --
    Uncharacterized protein
    9(a)
    1 → many
    8(2641142-2673492)
    lizard
    (Anolis carolinensis)
    Reptilia --
    Uncharacterized protein
    16(a)
    many ↔ many
    GL343432.1(90904-106115)
    zebrafish
    (Danio rerio)
    Actinopterygii cfhl56
    complement factor H like 5
    13(a)
    many ↔ many
    22(24286454-24301215) ENSDARG00000092786


    ENSEMBL Gene Tree for CFHR1 (if available)
    TreeFam Gene Tree for CFHR1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CFHR1 gene
    CFHR42  F13B2  CFHR22  CFHR52  CFHR32  CFH2  
    7 SIMAP similar genes for CFHR1 using alignment to 2 protein entries:     FHR1_HUMAN (see all proteins):
    CFHL1P    CFHR2    HF    CFH    CFHR5    CFHR3
    CFHR4

    CFHR1 for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CFHR1
    PGOHUM00000245143


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CFHR1 (see all 454)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 1 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1413868531,2
    C--196790871(+) AGTGA-/GTGTGTG 1 -- int10--------
    rs1506096761,2
    C--196791587(+) AAAGA-/TTTTTT 1 -- int10--------
    rs350150561,2
    C--196793395(-) ACCTC-/AAAAAA 1 -- int10--------
    rs4416141,2
    C,F,A--203327761(-) TTCGGT/CGGGTC 1 -- us2k11Minor allele frequency- C:0.13NA 120
    rs4416071,2
    C--203327775(-) tctccT/Cgctcc 1 -- us2k13Minor allele frequency- C:0.40NA EA 242
    rs1428830191,2
    --203327798(+) CTGCCA/GTTTAC 1 -- us2k10--------
    rs1502362741,2
    --203327813(+) ACCCTC/TGGAAA 1 -- us2k10--------
    rs2017328141,2
    C--203327841(+) GGAAT-/GTCCCA 1 -- us2k10--------
    rs4241501,2
    --203327857(-) ctgcaA/C/Gctggg 1 -- us2k11NA 2
    rs1824263571,2
    --203327920(+) TTCCAG/TGGTGA 1 -- us2k10--------

    HapMap Linkage Disequilibrium report for CFHR1 (196788861 - 196801319 bp)

    Structural Variations
         Database of Genomic Variants (DGV) Selected variations for CFHR1 (see all 64):    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv820836CNV Deletion20802225
    dgv87e199CNV Deletion23128226
    esv2630480CNV Deletion19546169
    esv1001500CNV Deletion20482838
    esv2421560CNV Deletion20811451
    dgv88e199CNV Deletion23128226
    esv5113CNV Deletion18987735
    dgv55e201CNV Deletion23290073
    dgv54e201CNV Deletion23290073
    esv2672625CNV Deletion23128226

    Human Gene Mutation Database (HGMD): CFHR1
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CFHR1
    DNA2.0 Custom Variant and Variant Library Synthesis for CFHR1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 134371   
    OMIM disorders: 603075  235400  
    Selected diseases for CFHR1 (see all 27):    About MalaCards
    atypical hemolytic-uremic syndrome    complement factor h deficiency    nephropathy due to cfhr5 deficiency    macular degeneration, age-related, reduced risk of
    cfhr3 and cfhr1-related atypical hemolytic-uremic syndrome    hemolytic-uremic syndrome    lyme disease    relapsing fever
    takayasu's arteritis    membranoproliferative glomerulonephritis    age related macular degeneration    periodontal disease
    glomerulonephritis    periodontitis    non-hodgkin lymphoma    hodgkin's lymphoma
    influenza    systemic lupus erythematosus    hepatitis c    hepatitis

    2 diseases from the University of Copenhagen DISEASES database for CFHR1:
    hemolytic-uremic syndrome     Age related macular degeneration

    CFHR1 for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:
    The International Symposium on Pneumococci and Pneumococcal Diseases (ISPPD) 9 - 13 March 2014

    2 Novoseek inferred disease relationships for CFHR1 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    uremic syndrome 72.5 4 19861685 (2), 18449173 (1), 19528535 (1)
    lyme disease 66.7 3 19858303 (1)

    Genetic Association Database (GAD): CFHR1
    Human Genome Epidemiology (HuGE) Navigator: CFHR1 (14 documents)

    Export disorders for CFHR1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CFHR1 gene, integrated from 10 sources (see all 106):
    (articles sorted by number of sources associating them with CFHR1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Molecular cloning of a human serum protein structurally related to complement factor H. (PubMed id 1711047)1, 2, 3 Skerka C.... Zipfel P.F. (J. Biol. Chem. 1991)
    2. Cloning of the 1.4-kb mRNA species of human complement factor H reveals a novel member of the short consensus repeat family related to the carboxy terminal of the classical 150-kDa molecule. (PubMed id 1826708)1, 2, 3 Estaller C.... Weiss E.H. (J. Immunol. 1991)
    3. The high frequency of complement factor H related CFHR1 gene deletion is restricted to specific subgroups of patients with atypical haemolytic uraemic syndrome. (PubMed id 19435718)1, 4, 9 Dragon-Durey M.A....FrAcmeaux-Bacchi V. (J. Med. Genet. 2009)
    4. Epidemiological approach to identifying genetic predispositions for atypical hemolytic uremic syndrome. (PubMed id 20059470)1, 4 Sullivan M....Neumann H.P. (Ann. Hum. Genet. 2010)
    5. Associations of CFHR1-CFHR3 deletion and a CFH SNP to age-related macular degeneration are not independent. (PubMed id 20581873)1, 4 Raychaudhuri S....Daly M.J. (Nat. Genet. 2010)
    6. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    7. Risk of non-Hodgkin lymphoma in association with germline variation in complement genes. (PubMed id 19344414)1, 4 Cerhan J.R....Slager S.L. (Br. J. Haematol. 2009)
    8. Contribution of copy number variation in the regulation of complement activation locus to development of age-related macular degeneration. (PubMed id 19553609)1, 4 Schmid-Kubista K.E....Edwards A.O. (amp 2009)
    9. Deletion of CFHR3 and CFHR1 genes in age-related macular degeneration. (PubMed id 18084039)1, 4 Spencer K.L....Haines J.L. (Hum. Mol. Genet. 2008)
    10. Extended haplotypes in the complement factor H (CFH) and CFH-related (CFHR) family of genes protect against age-related macular degeneration: characterization, ethnic distribution and evolutionary implications. (PubMed id 17438673)1, 4 Hageman G.S....Dean M. (Ann. Med. 2006)

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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 3078 HGNC: 4888 AceView: CFH Ensembl:ENSG00000244414 euGenes: HUgn3078
    ECgene: CFHR1 H-InvDB: CFHR1

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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CFHR1 Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
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    Patent Information for CFHR1 gene:
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