Aliases for CFD Gene
External Ids for CFD Gene
Previous Symbols for CFD Gene
The protein encoded by this gene is a member of the trypsin family of peptidases. The encoded protein is a component of the alternative complement pathway best known for its role in humoral suppression of infectious agents. This protein is also a serine protease that is secreted by adipocytes into the bloodstream. Finally, the encoded protein has a high level of expression in fat, suggesting a role for adipose tissue in immune system biology. [provided by RefSeq, Jul 2008]
GeneCards Summary for CFD Gene
CFD (Complement Factor D (Adipsin)) is a Protein Coding gene. Diseases associated with CFD include complement factor d deficiency and recurrent neisseria infections due to factor d deficiency. Among its related pathways are Hemostasis and Hemostasis. GO annotations related to this gene include serine-type endopeptidase activity and serine-type peptidase activity. An important paralog of this gene is ELANE.
UniProtKB/Swiss-Prot for CFD Gene
Factor D cleaves factor B when the latter is complexed with factor C3b, activating the C3bbb complex, which then becomes the C3 convertase of the alternate pathway. Its function is homologous to that of C1s in the classical pathway