Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CFC1B Gene

Aliases for CFC1B Gene

  • Cripto, FRL-1, Cryptic Family 1B 2 3 5

External Ids for CFC1B Gene

Previous GeneCards Identifiers for CFC1B Gene

  • GC02P130997
  • GC02P131278

Summaries for CFC1B Gene

GeneCards Summary for CFC1B Gene

CFC1B (Cripto, FRL-1, Cryptic Family 1B) is a Protein Coding gene. An important paralog of this gene is CFC1.

Gene Wiki entry for CFC1B Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFC1B Gene

Genomics for CFC1B Gene

Regulatory Elements for CFC1B Gene

Genomic Location for CFC1B Gene

130,521,094 bp from pter
130,528,604 bp from pter
7,511 bases
Plus strand

Genomic View for CFC1B Gene

Genes around CFC1B on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CFC1B Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CFC1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFC1B Gene

Proteins for CFC1B Gene

  • Protein details for CFC1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cryptic family protein 1B
    Protein Accession:
    Secondary Accessions:
    • B2RCY0
    • B9EJD3
    • Q53T05
    • Q9GZR3

    Protein attributes for CFC1B Gene

    223 amino acids
    Molecular mass:
    24642 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CFC1B Gene

Post-translational modifications for CFC1B Gene

No Post-translational modifications

Other Protein References for CFC1B Gene

No data available for DME Specific Peptides for CFC1B Gene

Domains & Families for CFC1B Gene

Protein Domains for CFC1B Gene

Suggested Antigen Peptide Sequences for CFC1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Contains 1 EGF-like domain.
  • Contains 1 EGF-like domain.
genes like me logo Genes that share domains with CFC1B: view

No data available for Gene Families for CFC1B Gene

Function for CFC1B Gene

genes like me logo Genes that share phenotypes with CFC1B: view

Animal Models for CFC1B Gene

MGI Knock Outs for CFC1B:

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , miRNA , Transcription Factor Targets and HOMER Transcription for CFC1B Gene

Localization for CFC1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFC1B Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CFC1B gene
Compartment Confidence
extracellular 5
mitochondrion 1
cytosol 1

Gene Ontology (GO) - Cellular Components for CFC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CFC1B: view

Pathways & Interactions for CFC1B Gene

SuperPathways for CFC1B Gene

No Data Available

Interacting Proteins for CFC1B Gene

Gene Ontology (GO) - Biological Process for CFC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007275 multicellular organism development IEA --
GO:0007369 gastrulation IEA --
genes like me logo Genes that share ontologies with CFC1B: view

No data available for Pathways by source and SIGNOR curated interactions for CFC1B Gene

Transcripts for CFC1B Gene

mRNA/cDNA for CFC1B Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CFC1B Gene

Cripto, FRL-1, cryptic family 1B:
Representative Sequences:

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CFC1B Gene

No ASD Table

Relevant External Links for CFC1B Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CFC1B Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CFC1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CFC1B Gene

This gene is overexpressed in Pituitary (x28.1), Brain - Hypothalamus (x14.1), and Pancreas (x4.4).

NURSA nuclear receptor signaling pathways regulating expression of CFC1B Gene:


SOURCE GeneReport for Unigene cluster for CFC1B Gene:

genes like me logo Genes that share expression patterns with CFC1B: view

Primer Products

No data available for Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CFC1B Gene

Orthologs for CFC1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CFC1B Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia -- 35
  • 99 (a)
CFC1 34
  • 98.95 (n)
(Canis familiaris)
Mammalia LOC609557 34
  • 78.59 (n)
-- 35
  • 48 (a)
(Mus musculus)
Mammalia Cfc1 34 16 35
  • 65.5 (n)
(Rattus norvegicus)
Mammalia Cfc1 34
  • 64.65 (n)
(Monodelphis domestica)
Mammalia -- 35
  • 37 (a)
(Gallus gallus)
Aves CFC1B 34
  • 51.43 (n)
CFC1 35
  • 34 (a)
(Anolis carolinensis)
Reptilia -- 35
  • 31 (a)
(Danio rerio)
Actinopterygii oep 35
  • 29 (a)
Species where no ortholog for CFC1B was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFC1B Gene

Gene Tree for CFC1B (if available)
Gene Tree for CFC1B (if available)

Paralogs for CFC1B Gene

Paralogs for CFC1B Gene

(1) SIMAP similar genes for CFC1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CFC1B: view

Variants for CFC1B Gene

Sequence variations from dbSNP and Humsavar for CFC1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type
rs113449980 -- 130,528,473(+) TGACA(C/T)AATTA intron-variant
rs114865627 -- 130,528,474(+) GACAC(A/G)ATTAC intron-variant
rs1344974 -- 130,524,254(+) GCAGG(C/G)GGGGA intron-variant
rs1561449 -- 130,527,307(-) CTTCC(A/G)TCTGC intron-variant
rs182906925 -- 130,525,898(+) CTCTG(C/G)GGGTC intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CFC1B Gene

Variant ID Type Subtype PubMed ID
nsv961509 CNV duplication 23825009
nsv953164 CNV deletion 24416366
nsv7327 OTHER inversion 18451855
nsv583134 CNV loss 21841781
nsv428403 CNV loss 18775914
nsv1148026 CNV duplication 26484159
nsv1147463 OTHER inversion 26484159
nsv1072451 CNV deletion 25765185
nsv1005664 CNV loss 25217958
esv3592455 CNV loss 21293372
esv2759092 CNV gain+loss 17122850
dgv4074n100 CNV gain 25217958
dgv2035n106 CNV duplication 24896259
dgv2032n106 OTHER inversion 24896259

Variation tolerance for CFC1B Gene

Gene Damage Index Score: 1.87; 34.93% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CFC1B Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CFC1B Gene

Disorders for CFC1B Gene

Relevant External Links for CFC1B

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CFC1B Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CFC1B Gene

Publications for CFC1B Gene

  1. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4 64
  2. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3 64

Products for CFC1B Gene

Sources for CFC1B Gene

Loading form....