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Aliases for CFC1B Gene

Aliases for CFC1B Gene

  • Cripto, FRL-1, Cryptic Family 1B 2 3

External Ids for CFC1B Gene

Previous GeneCards Identifiers for CFC1B Gene

  • GC02P130997
  • GC02P131278

Summaries for CFC1B Gene

GeneCards Summary for CFC1B Gene

CFC1B (Cripto, FRL-1, Cryptic Family 1B) is a Protein Coding gene. An important paralog of this gene is CFC1.

Gene Wiki entry for CFC1B Gene

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFC1B Gene

Genomics for CFC1B Gene

Regulatory Elements for CFC1B Gene

Genomic Location for CFC1B Gene

Start:
130,521,094 bp from pter
End:
130,528,604 bp from pter
Size:
7,511 bases
Orientation:
Plus strand

Genomic View for CFC1B Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CFC1B Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFC1B Gene

Proteins for CFC1B Gene

  • Protein details for CFC1B Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P0CG36-CFC1B_HUMAN
    Recommended name:
    Cryptic family protein 1B
    Protein Accession:
    P0CG36
    Secondary Accessions:
    • B2RCY0
    • B9EJD3
    • Q53T05
    • Q9GZR3

    Protein attributes for CFC1B Gene

    Size:
    223 amino acids
    Molecular mass:
    24642 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CFC1B Gene

Proteomics data for CFC1B Gene at MOPED

Post-translational modifications for CFC1B Gene

Other Protein References for CFC1B Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CFC1B Gene

Domains for CFC1B Gene

Protein Domains for CFC1B Gene

Suggested Antigen Peptide Sequences for CFC1B Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P0CG36

UniProtKB/Swiss-Prot:

CFC1B_HUMAN :
  • P0CG36
Domain:
  • Contains 1 EGF-like domain.
genes like me logo Genes that share domains with CFC1B: view

No data available for Gene Families for CFC1B Gene

Function for CFC1B Gene

Gene Ontology (GO) - Molecular Function for CFC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CFC1B: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CFC1B Gene

Localization for CFC1B Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFC1B Gene

Secreted.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CFC1B Gene COMPARTMENTS Subcellular localization image for CFC1B gene
Compartment Confidence
extracellular 5
plasma membrane 5
cytosol 1
mitochondrion 1

Gene Ontology (GO) - Cellular Components for CFC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CFC1B: view

Pathways for CFC1B Gene

SuperPathways for CFC1B Gene

No Data Available

Interacting Proteins for CFC1B Gene

Gene Ontology (GO) - Biological Process for CFC1B Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007369 gastrulation IEA --
genes like me logo Genes that share ontologies with CFC1B: view

No data available for Pathways by source for CFC1B Gene

Transcripts for CFC1B Gene

mRNA/cDNA for CFC1B Gene

(2) REFSEQ mRNAs :
(0) Additional mRNA sequences :
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CFC1B Gene

Cripto, FRL-1, cryptic family 1B:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CFC1B Gene

No ASD Table

Relevant External Links for CFC1B Gene

GeneLoc Exon Structure for
CFC1B
ECgene alternative splicing isoforms for
CFC1B

Expression for CFC1B Gene

mRNA expression in normal human tissues for CFC1B Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CFC1B Gene

This gene is overexpressed in Pituitary (28.1), Brain - Hypothalamus (14.1), and Pancreas (4.4).

SOURCE GeneReport for Unigene cluster for CFC1B Gene Hs.503733

genes like me logo Genes that share expressions with CFC1B: view

No data available for Protein expression and mRNA Expression by UniProt/SwissProt for CFC1B Gene

Orthologs for CFC1B Gene

This gene was present in the common ancestor of chordates.

Orthologs for CFC1B Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia -- 36
  • 99 (a)
OneToMany
CFC1 35
  • 98.95 (n)
  • 98.65 (a)
dog
(Canis familiaris)
Mammalia -- 36
  • 48 (a)
OneToMany
LOC609557 35
  • 78.59 (n)
  • 65.45 (a)
mouse
(Mus musculus)
Mammalia Cfc1 35
  • 65.5 (n)
  • 54.39 (a)
Cfc1 36
  • 48 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 37 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Cfc1 35
  • 64.65 (n)
  • 55.7 (a)
chicken
(Gallus gallus)
Aves CFC1 36
  • 34 (a)
OneToMany
CFC1B 35
  • 51.43 (n)
  • 41.06 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 31 (a)
OneToMany
zebrafish
(Danio rerio)
Actinopterygii oep 36
  • 29 (a)
OneToMany
Species with no ortholog for CFC1B:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFC1B Gene

ENSEMBL:
Gene Tree for CFC1B (if available)
TreeFam:
Gene Tree for CFC1B (if available)

Paralogs for CFC1B Gene

Paralogs for CFC1B Gene

Selected SIMAP similar genes for CFC1B Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CFC1B: view

Variants for CFC1B Gene

Sequence variations from dbSNP and Humsavar for CFC1B Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs934903 -- 130,526,950(+) GGGCA(C/G)GGTCT intron-variant
rs1344974 -- 130,524,254(+) GCAGG(C/G)GGGGA intron-variant
rs1561449 -- 130,527,307(-) CTTCC(A/G)TCTGC intron-variant
rs2579423 -- 130,527,434(+) ACGAA(C/G)AACAG intron-variant
rs2579424 -- 130,525,899(-) GGACC(C/T)GCAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CFC1B Gene

Variant ID Type Subtype PubMed ID
dgv1247e1 CNV Complex 17122850
dgv1250e1 CNV Complex 17122850
nsv428403 CNV Loss 18775914
nsv7327 OTHER Inversion 18451855
nsv875103 CNV Gain 21882294

Relevant External Links for CFC1B Gene

HapMap Linkage Disequilibrium report
CFC1B

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CFC1B Gene

Disorders for CFC1B Gene

No disorders were found for CFC1B Gene.

No data available for UniProtKB/Swiss-Prot for CFC1B Gene

Publications for CFC1B Gene

  1. Normalization and subtraction: two approaches to facilitate gene discovery. (PMID: 8889548) Bonaldo M.F. … Soares M.B. (Genome Res. 1996) 3
  2. Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PMID: 15815621) Hillier L.W. … Wilson R.K. (Nature 2005) 4

Products for CFC1B Gene

Sources for CFC1B Gene

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