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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CFC1B Gene

protein-coding GIFtS: 35
GCID: GC02P131278

cripto, FRL-1, cryptic family 1B

Search for CFC1B
in

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our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cripto, FRL-1, Cryptic Family 1B¹ ²
Cryptic Family Protein 1B²

External Ids:	HGNC: 33983¹	Entrez Gene: 653275²	Ensembl: ENSG00000152093⁷	UniProtKB: P0CG36³

Export aliases for CFC1B gene to outside databases

Previous GC identifer: GC02P130997

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Gene Wiki entry for CFC1B (Cripto)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NT_022135.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CFC1B gene promoter:
Oct-B1 oct-B3 oct-B2 AML1a Nkx2-2 C/EBPalpha Evi-1 POU2F1 GATA-6 POU2F1a
Other transcription factors

Browse SwitchGear Promoter luciferase reporter plasmids

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Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CFC1B

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1 Ensembl cytogenetic band: 2q21.1 HGNC cytogenetic band: 2q21.1

CFC1B Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CFC1B gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02P131278: view genomic region (about GC identifiers)

Start:	131,278,667 bp from pter	End:	131,285,579 bp from pter
Size:	6,913 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
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About This Section

UniProtKB/Swiss-Prot: CFC1B_HUMAN, P0CG36 (See protein sequence)

Recommended Name: Cryptic family protein 1B precursor

Size: 223 amino acids; 24642 Da

Subcellular location: Secreted (Potential)

Caution: This gene differs from CFC1 by only one residue at position 78:R -> W. R78W is also thought to be a CFC1

polymorphism

Secondary accessions: B2RCY0 B9EJD3 Q53T05 Q9GZR3

Explore the universe of human proteins at neXtProt for CFC1B: NX_P0CG36

CFC1B Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_001072998.1

ENSEMBL proteins:

ENSP00000281882

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	Uscn Proteins for CFC1B

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005576	extracellular region	IEA	--

CFC1B for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CFC1B for domains About GeneDecksing

3 InterPro domains/families:

IPR000742 EG-like_dom

IPR019011 Cryptic/Cripto_CFC-dom

IPR013032 EGF-like_CS

Graphical View of Domain Structure for InterPro Entry P0CG36

ProtoNet protein and cluster: P0CG36

UniProtKB/Swiss-Prot: CFC1B_HUMAN, P0CG36

Similarity: Contains 1 EGF-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

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(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CFC1B

Gene Ontology (GO): 1 biological process term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007369	gastrulation	IEA	--

CFC1B for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

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Search CenterWatch for drugs/clinical trials and news about CFC1B

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
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About This Section

REFSEQ mRNAs for CFC1B gene:

NM_001079530.1

Unigene Cluster for CFC1B:

Cripto, FRL-1, cryptic family 1B

Hs.503733 [show with all ESTs]

Unigene Representative Sequence: NM_001079530

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000281882(uc002trl.1)

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11 DOTS entries:

DT.120981469 DT.120981526 DT.120981012 DT.120981442 DT.97833321 DT.111026 DT.120981140 DT.70105380

DT.120981189 DT.100812210 DT.95095721

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CFC1B expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: AAAGCGCAAA

About this image

CFC1B expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

Stem Cell Differentiation: 1 LifeMap Cell

Name

Category

Mesoderm-like cells (Derivation of cardio...)

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CFC1B Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CFC1B

SOURCE GeneReport for Unigene cluster: Hs.503733

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In Situ
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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CFC1B gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CFC1B¹	cripto, FRL-1, cryptic family 1B	51.23(n) 41.61(a)		395437 NM_204700.1 NP_990031.1
lizard (Anolis carolinensis)	Reptilia	-- TDGF1⁶	--	34(a) 34(a)	1 ↔ many possible ortholog	2(39717323-39726514) 2(39802641-39805737)
zebrafish (Danio rerio)	Actinopterygii	oep⁶	one-eyed pinhead	28(a)	1 → many	10(1983898-1990349)

ENSEMBL Gene Tree for CFC1B (if available)
TreeFam Gene Tree for CFC1B (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CFC1B gene

CFC1¹ ² TDGF1²

1 SIMAP similar gene for CFC1B using alignment to 1 protein entry: CFC1B_HUMAN:

CFC1

CFC1B for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs190727215^1,2		--	131279681(+)	`CTCCCA/CTACTC`	2	P	syn¹		0	--	--	--	--
rs182508174^1,2		--	131279688(+)	`ACTCCC/TGGGCT`	2	R W	mis¹		0	--	--	--	--
rs200159465^1,2		--	131280812(+)	`TCGGGA/GCCCTG`	2	T A	mis¹		0	--	--	--	--
rs186252711^1,2		--	131281393(+)	`AGGCCC/TGGGTG`	1	--	int¹		0	--	--	--	--
rs190648510^1,2		--	131281827(+)	`TCCCCC/GCCTGC`	1	--	int¹		0	--	--	--	--
rs182906925^1,2		--	131283471(+)	`CTCTGC/GGGGTC`	1	--	int¹		0	--	--	--	--
rs150596221^1,2		--	131284174(+)	`ACAGCC/TTACCT`	1	--	int¹		0	--	--	--	--
rs187205122^1,2		--	131285007(+)	`CTGTTC/GTTCGT`	1	--	int¹		0	--	--	--	--
rs79828060^1,2		--	131286031(+)	`GTTCAC/TGAGCC`	1	--	int¹		1		NA	2
rs114865627^1,2	F,	--	131286047(+)	`GACACA/GATTAC`	1	--	int¹		1		WA	118

HapMap Linkage Disequilibrium report for CFC1B (131278667 - 131285579 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CFC1B
2 CNVs: 3393 2408

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(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CFC1B gene integrated from 9 sources:
(articles sorted by number of sources associating them with CFC1B)

Utopia: connect your pdf to the dynamic
world of online information

Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)² Hillier L.W....Wilson R.K. (2005)
Normalization and subtraction: two approaches to facilitate gene discovery. (PubMed id 8889548)¹ Bonaldo M.F.... Soares M.B. (1996)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
	(Note: In FireFox, select the above section and copy using Ctrl-C)

(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
About This Section

Entrez Gene: 653275	HGNC: 33983	Ensembl:ENSG00000152093	euGenes: HUgn653275	ECgene: CFC1B
H-InvDB: CFC1B

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CFC1B	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CFC1B gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CFC1B gene:
Search GeneIP for patents involving CFC1B

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

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About This Section


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CFC1B Gene

cripto, FRL-1, cryptic family 1B

Aliases
for CFC1B gene

Summaries
for CFC1B gene

Genomic Views
for CFC1B gene

Proteins
for CFC1B gene

Protein Domains /
Families
for CFC1B gene

Function
for CFC1B gene

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CFC1B Gene

cripto, FRL-1, cryptic family 1B

Aliasesfor CFC1B gene

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Proteinsfor CFC1B gene

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Functionfor CFC1B gene

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Transcriptsfor CFC1B gene

Expression for CFC1B gene

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Disorders / Diseasesfor CFC1B gene

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External Searches for CFC1B gene

Genome Databases showing CFC1B gene

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Specialized Databases showing CFC1B gene

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Aliases
for CFC1B gene

Summaries
for CFC1B gene

Genomic Views
for CFC1B gene

Proteins
for CFC1B gene

Protein Domains /
Families
for CFC1B gene

Function
for CFC1B gene

Pathways & Interactions
for CFC1B gene

Drugs & Compounds
for CFC1B gene

Transcripts
for CFC1B gene

Expression
for CFC1B gene

Orthologs
for CFC1B gene

Paralogs
for CFC1B gene

Genomic Variants
for CFC1B gene

Disorders / Diseases
for CFC1B gene

Publications
for CFC1B gene

Intellectual Property
for CFC1B gene

Products
for CFC1B gene