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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CFC1 Gene

protein-coding GIFtS: 53
GCID: GC02M131350

cripto, FRL-1, cryptic family 1

Explore 10 diseases affiliated with
CFC1 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Cripto, FRL-1, Cryptic Family 1¹ ²		CFC1B²
CRYPTIC¹ ² ⁵		DTGA2²
HTX2¹ ² ⁵		Cryptic Protein²
Cryptic Family Protein 1² ³

External Ids:	HGNC: 18292¹	Entrez Gene: 55997²	Ensembl: ENSG00000136698⁷	OMIM: 605194⁵	UniProtKB: P0CG37³

Export aliases for CFC1 gene to outside databases

Previous GC identifers: GC02P131372 GC02M131066 GC02M123494

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CFC1:

This gene encodes a member of the epidermal growth factor (EGF)- Cripto, Frl-1, and Cryptic (CFC) family, which are

involved in signalling during embryonic development. Proteins in this family share a variant EGF-like motif, a

conserved cysteine-rich domain, and a C-terminal hydrophobic region. The protein encoded by this gene is necessary for

patterning the left-right embryonic axis. Mutations in this gene are associated with defects in organ development,

including autosomal visceral heterotaxy and congenital heart disease. Alternatively spliced transcript variants

encoding multiple isoforms have been observed for this gene. (provided by RefSeq, Jul 2012)

UniProtKB/Swiss-Prot: CFC1_HUMAN, P0CG37

Function: NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm

and/or neural patterning during gastrulation

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000002.11 NC_018913.1 NT_022135.16

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CFC1 gene promoter:
AML1a AP-2alpha isoform 3 AP-2alpha isoform 2 AP-2alpha isoform 4 AP-2alpha AP-2alphaA
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CFC1 promoter sequence

Search SABiosciences Chromatin IP Primers for CFC1

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CFC1

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 2q21.1 Ensembl cytogenetic band: 2q21.1 HGNC cytogenetic band: 2q21.2

CFC1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CFC1 gene location

GeneLoc information about chromosome 2 GeneLoc Exon Structure

GeneLoc location for GC02M131350: view genomic region (about GC identifiers)

Start:	131,350,335 bp from pter	End:	131,357,123 bp from pter
Size:	6,789 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CFC1_HUMAN, P0CG37 (See protein sequence)

Recommended Name: Cryptic protein precursor

Size: 223 amino acids; 24612 Da

Subcellular location: Cell membrane; Lipid-anchor, GPI-anchor. Secreted. Note=Does not exhibit a typical GPI-signal

sequence. The C-ter hydrophilic extension of the GPI-signal sequence reduces the efficiency of processing and could

lead to the production of an secreted unprocessed form. This extension is found only in primates

Caution: This gene differs from CFC1B by only one residue at position 78:R -> W. R78W is also thought to be a CFC1

polymorphism which has been shown to lead to a different cell surface distribution and activity (PubMed:11799476 and

PubMed:11062482)

Secondary accessions: B2RCY0 B9EJD3 Q53T05 Q9GZR3

Explore the universe of human proteins at neXtProt for CFC1: NX_P0CG37

Post-translational modifications:

N-glycosylated (By similarity)¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_P0CG37

CFC1 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001257349.1 NP_001257350.1 NP_115934.1

ENSEMBL proteins:

ENSP00000259216

Reactome Protein details: P0CG37
Human Recombinant Protein Products:

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	Novus Biologicals CFC1 Proteins Novus Biologicals CFC1 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CFC1

Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005575	cellular_component	ND	--
GO:0005576	extracellular region	IEA	--
GO:0005886	plasma membrane	IEA	--
GO:0031225	anchored to membrane	IEA	--

CFC1 for ontologies About GeneDecksing

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	Uscn ELISAs and CLIAs for CFC1

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CFC1 for domains About GeneDecksing

3 InterPro domains/families:

IPR000742 EG-like_dom

IPR019011 Cryptic/Cripto_CFC-dom

IPR013032 EGF-like_CS

Graphical View of Domain Structure for InterPro Entry P0CG37

ProtoNet protein and cluster: P0CG37

UniProtKB/Swiss-Prot: CFC1_HUMAN, P0CG37

Similarity: Contains 1 EGF-like domain

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: CFC1_HUMAN, P0CG37

Function: NODAL coreceptor involved in the correct establishment of the left-right axis. May play a role in mesoderm

and/or neural patterning during gastrulation

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CFC1
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		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CFC1 (see all 7) OriGene shRNA RFP: CFC1 OriGene siRNA: CFC1
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Gene Editing
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		Search LifeMap BioReagents cell lines for CFC1

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFC1

Gene Ontology (GO): 2 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0003674	molecular_function	ND	--
GO:0038100	nodal binding	IPI	12052855

CFC1 for ontologies           About GeneDecksing

Animal Models:
     Mouse knock-out Cfc1^tm1Mms for CFC1
     10 MGI mutant phenotypes (inferred from 3 alleles) (MGI details for Cfc1):

cardiovascular system	digestive/alimentary	embryogenesis	growth/size	hematopoietic system
immune system	liver/biliary system	mortality/aging	respiratory system	skeleton

CFC1 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

Signaling by NODAL

Signaling by NODAL

1.00

Regulation of Signaling by NODAL

0.56

Axon guidance

Developmental Biology

0.69

Pathway sources
See GeneCards unified pathways
Show all pathways

3 Reactome Pathways for CFC1

	Developmental Biology
	Signaling by NODAL
	Regulation of Signaling by NODAL

CFC1 for pathways About GeneDecksing

Interactions:

SABiosciences Gene Network Central^TM Interacting Genes and Proteins Network for CFC1

1 Interacting protein for CFC1 (P0CG37³) via UniProtKB, MINT, STRING, and/or I2D

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
NODAL	Q96S42³	I2D: score=1

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007368	determination of left/right symmetry	NAS	11062482
GO:0007369	gastrulation	IEA	--
GO:0038092	nodal signaling pathway	IMP	12052855

CFC1 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CFC1
Search CenterWatch for drugs/clinical trials and news about CFC1

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CFC1 gene (3 alternative transcripts):

NM_001270420.1 NM_001270421.1 NM_032545.3

Unigene Cluster for CFC1:

Cripto, FRL-1, cryptic family 1

Hs.567542 [show with all ESTs]

Unigene Representative Sequence: NM_032545

1 Ensembl transcript including schematic representation, and UCSC links where relevant:

ENST00000259216(uc002tro.1)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CFC1
		Search QIAGEN for miScript miRNA Assays for microRNAs that regulate CFC1
		Browse SwitchGear 3'UTR luciferase reporter plasmids

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CFC1 (see all 7) OriGene shRNA RFP: CFC1 OriGene siRNA: CFC1
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CFC1

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CFC1 (see all 3) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CFC1 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector: CFC1 (NM_005334)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CFC1
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Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CFC1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CFC1
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CFC1

Additional cDNA sequence:

AF312769.1 AK290094.1 AK315326.1 BC069508.1 BC074825.2 BC074826.2 BC110080.1 BC146897.1

DQ786275.1

10 DOTS entries:

DT.120981469 DT.111026 DT.120981189 DT.70105380 DT.100812210 DT.120981140 DT.120981442 DT.95095721

DT.95206580 DT.97833321

24/81 AceView cDNA sequences (see all 81):

BQ787192 BM975147 BM701258 CA943471 BM142331 AI732919 BM674383 BM684520

BQ189720 CA943425 BU948650 BM310214 BQ416625 BQ186931 BM311359 BU786067

BI710843 CA941513 BU071589 BU072425 AI791237 BU784123 BQ416624 BI964234

GeneLoc Exon Structure

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CFC1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CGGAATGTGC

About this image

CFC1 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Primitive Streak

Primitive Streak Cells

Early Embryo

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CFC1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CFC1

SOURCE GeneReport for Unigene cluster: Hs.567542

SABiosciences Custom PCR Arrays for CFC1

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CFC1 Browse OriGene validated miRNA SYBR primer pairs
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		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CFC1

In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CFC1

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of chordates.

Orthologs for CFC1 gene from 3/9 species (see all 9) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CFC1B¹	cripto, FRL-1, cryptic family 1B	51.23(n) 41.61(a)		395437 NM_204700.1 NP_990031.1
lizard (Anolis carolinensis)	Reptilia	-- TDGF1⁶	--	34(a) 34(a)	1 ↔ many possible ortholog	2(39717323-39726514) 2(39802641-39805737)
zebrafish (Danio rerio)	Actinopterygii	oep⁶	one-eyed pinhead	28(a)	1 → many	10(1983898-1990349)

ENSEMBL Gene Tree for CFC1 (if available)
TreeFam Gene Tree for CFC1 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CFC1 gene

CFC1B¹ ² TDGF1²

2 SIMAP similar genes for CFC1 using alignment to 1 protein entry: CFC1_HUMAN:

CFC1B TDGF1P3

CFC1 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 2 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs104893611^1,2	C	pathogenic	131355469(-)	`CCGGCC/TGCTAC`	4	R C	mis¹ int¹		0	--	--	--	--
rs2741410^1,2		--	131349872(-)	`TGACAC/TAATTA`	3	--	ut3¹		0	--	--	--	--
rs3213896^1,2	C,	--	131349899(+)	`ACAGTG/AGATTT`	3	--	ut3¹		1		NA	2
rs201025322^1,2		--	131350900(+)	`TTAAA-/GGGGGA`	3	--	int¹		0	--	--	--	--
rs143666296^1,2		--	131351038(+)	`CTTCCA/GTCTGC`	3	--	int¹		0	--	--	--	--
rs192903257^1,2		--	131351750(+)	`GCTGTA/GGTAGC`	3	--	int¹		0	--	--	--	--
rs185056892^1,2		--	131351755(+)	`GGTAGC/GATTGG`	3	--	int¹		0	--	--	--	--
rs199967857^1,2		--	131351806(+)	`TAGCA-/CCCCCCA`	3	--	int¹		0	--	--	--	--
rs189600329^1,2		--	131352905(+)	`TTCTCA/GAACTC`	3	--	int¹		0	--	--	--	--
rs199715380^1,2		--	131355106(+)	`CAGGGC/TCCCGA`	5	G T A	int¹ syn¹ mis¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CFC1 (131350335 - 131357123 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 2 variations for CFC1
2 CNVs: 3393 2408
Human Gene Mutation Database (HGMD): CFC1

SABiosciences Cancer Mutation PCR Assays

Search QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CFC1

DNA2.0 Custom Variant and Variant Library Synthesis for CFC1

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CFC1 for disorders           About GeneDecksing

OMIM gene information: 605194
OMIM disorders: 605376  217095
UniProtKB/Swiss-Prot: CFC1_HUMAN, P0CG37

Defects in CFC1 are the cause of visceral heterotaxy autosomal type 2 (HTX2) [MIM:605376]. A form of visceral

heterotaxy, a complex disorder due to disruption of the normal left-right asymmetry of the thoracoabdominal organs. It

results in an abnormal arrangement of visceral organs, and a wide variety of congenital defects including cardiac

malformations and situs inversus or situs ambiguus

Defects in CFC1 are a cause of transposition of the great arteries dextro-looped type 2 (DTGA2) [MIM:613853].

A congenital heart defect consisting of complete inversion of the great vessels, so that the aorta incorrectly arises

from the right ventricle and the pulmonary artery incorrectly arises from the left ventricle. This creates completely

separate pulmonary and systemic circulatory systems, an arrangement that is incompatible with life. Patients often

have atrial and/or ventricular septal defects or other types of shunting that allow some mixing between the

circulations in order to support life minimally, but surgical intervention is always required

Defects in CFC1 are a cause of conotruncal heart malformations (CTHM) [MIM:217095]. CTHM consist of cardiac

outflow tract defects, such as tetralogy of Fallot, pulmonary atresia, double-outlet right ventricle, truncus

arteriosus communis, and aortic arch anomalies

10 diseases for CFC1: About MalaCards

transposition of the great arteries, dextro-looped 2 visceral heterotaxy double outlet right ventricle heterotaxy

transposition of great arteries conotruncal heart malformations situs ambiguus situs inversus

tetralogy of fallot biliary atresia

2 diseases from the University of Copenhagen DISEASES database for CFC1:

Ventricular septal defect Biliary atresia

Genetic Association Database (GAD): CFC1
Human Genome Epidemiology (HuGE) Navigator: CFC1 (4 documents)

Export disorders for CFC1 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CFC1 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with CFC1)

Utopia: connect your pdf to the dynamic
world of online information

Loss-of-function mutations in the EGF-CFC gene CFC1 are associated with human left-right laterality defects. (PubMed id 11062482)^{1, 2, 3, 4, 9} Bamford R.N.... Casey B. (2000)
CFC1 mutations in patients with transposition of the great arteries and double-outlet right ventricle. (PubMed id 11799476)^{1, 2, 9} Goldmuntz E....Muenke M. (2002)
Characterization of the glycosylphosphatidylinositol-anchor signal sequence of human Cryptic with a hydrophilic extension. (PubMed id 18930707)^{1, 2} Watanabe K....Salomon D.S. (2008)
Generation and annotation of the DNA sequences of human chromosomes 2 and 4. (PubMed id 15815621)^{1, 2} Hillier L.W....Wilson R.K. (2005)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
The EGF-CFC gene family in vertebrate development. (PubMed id 10858660)^{1, 3} Shen M.M. and Schier A.F. (2000)
Molecular evolution of the EGF-CFC protein family. (PubMed id 21640172)¹ Ravisankar V....Manoj N. (2011)
Maternal genes and facial clefts in offspring: a comp rehensive search for genetic associations in two population-based cleft studies from Scandinavia. (PubMed id 20634891)¹ Jugessur A....Murray J.C. (2010)
CFC1 mutations in Chinese children with congenital he art disease. (PubMed id 19853937)¹ Wang B....Ma X. (2009)
Candidate genes associated with malignant pheochromocy tomas by genome-wide expression profiling. (PubMed id 19661783)¹ Suh I....Kebebew E. (2009)

(in PubMed, OMIM, and NCBI Bookshelf)
About This Section

		AND	OR
Aliases
Free Text

Query String		PubMed OMIM NCBI Bookshelf
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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 55997	HGNC: 18292	AceView: CFC1.1	Ensembl:ENSG00000136698	euGenes: HUgn55997
ECgene: CFC1	H-InvDB: CFC1

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CFC1	Pharmacogenomics, SNPs, Pathways
GeneReviews	http://www.ncbi.nlm.nih.gov/sites/GeneTests/lab/gene/CFC1

Intellectual Property for CFC1 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CFC1 gene:
Search GeneIP for patents involving CFC1

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences),
In Situ Hybridization Assays from
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CFC1 Gene

cripto, FRL-1, cryptic family 1

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CFC1 Gene

cripto, FRL-1, cryptic family 1

Aliasesfor CFC1 gene

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for CFC1 gene

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Transcripts
for CFC1 gene

Expression
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Orthologs
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Genomic Variants
for CFC1 gene

Disorders / Diseases
for CFC1 gene

Publications
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Intellectual Property
for CFC1 gene

Products
for CFC1 gene