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Aliases for CFAP97 Gene

Aliases for CFAP97 Gene

  • Cilia And Flagella Associated Protein 97 2 3 5
  • KIAA1430 2 3 4
  • Hmw 3

External Ids for CFAP97 Gene

Previous HGNC Symbols for CFAP97 Gene

  • KIAA1430

Summaries for CFAP97 Gene

GeneCards Summary for CFAP97 Gene

CFAP97 (Cilia And Flagella Associated Protein 97) is a Protein Coding gene. Diseases associated with CFAP97 include Primary Ciliary Dyskinesia.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFAP97 Gene

Genomics for CFAP97 Gene

Regulatory Elements for CFAP97 Gene

Enhancers for CFAP97 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CFAP97 on UCSC Golden Path with GeneCards custom track

Promoters for CFAP97 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CFAP97 on UCSC Golden Path with GeneCards custom track

Genomic Location for CFAP97 Gene

Chromosome:
4
Start:
185,151,723 bp from pter
End:
185,209,504 bp from pter
Size:
57,782 bases
Orientation:
Minus strand

Genomic View for CFAP97 Gene

Genes around CFAP97 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CFAP97 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CFAP97 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFAP97 Gene

Proteins for CFAP97 Gene

  • Protein details for CFAP97 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2B7-CFA97_HUMAN
    Recommended name:
    Cilia- and flagella-associated protein 97
    Protein Accession:
    Q9P2B7
    Secondary Accessions:
    • B3KRP7
    • D3DP60
    • Q05CU1
    • Q4W5M4
    • Q8N6E7
    • Q9UF45

    Protein attributes for CFAP97 Gene

    Size:
    532 amino acids
    Molecular mass:
    59475 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH20772.1; Type=Frameshift; Positions=50; Evidence={ECO:0000305}; Sequence=AAH20772.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAY40976.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CFAP97 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CFAP97 Gene

Proteomics data for CFAP97 Gene at MOPED

Post-translational modifications for CFAP97 Gene

  • Ubiquitination at Lys 375
  • Modification sites at PhosphoSitePlus

Other Protein References for CFAP97 Gene

No data available for DME Specific Peptides for CFAP97 Gene

Domains & Families for CFAP97 Gene

Protein Domains for CFAP97 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CFAP97 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2B7

UniProtKB/Swiss-Prot:

CFA97_HUMAN :
  • Belongs to the CFAP97 family.
Family:
  • Belongs to the CFAP97 family.
genes like me logo Genes that share domains with CFAP97: view

No data available for Gene Families for CFAP97 Gene

Function for CFAP97 Gene

Animal Model Products

miRNA for CFAP97 Gene

miRTarBase miRNAs that target CFAP97

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CFAP97 Gene

Localization for CFAP97 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CFAP97 Gene

Pathways & Interactions for CFAP97 Gene

SuperPathways for CFAP97 Gene

No Data Available

Interacting Proteins for CFAP97 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000409964%0d%0a9606.ENSP00000344818%0d%0a
Selected Interacting proteins: ENSP00000409964 for CFAP97 Gene via STRING

Symbol External ID(s) Details
UBC

Gene Ontology (GO) - Biological Process for CFAP97 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CFAP97 Gene

Drugs & Compounds for CFAP97 Gene

No Compound Related Data Available

Transcripts for CFAP97 Gene

mRNA/cDNA for CFAP97 Gene

(6) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CFAP97 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: - -
SP2:

Relevant External Links for CFAP97 Gene

GeneLoc Exon Structure for
CFAP97
ECgene alternative splicing isoforms for
CFAP97

Expression for CFAP97 Gene

mRNA expression in normal human tissues for CFAP97 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CFAP97 Gene

This gene is overexpressed in Monocytes (36.5), Prostate (16.3), and Testis (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CFAP97 Gene



genes like me logo Genes that share expression patterns with CFAP97: view

Protein tissue co-expression partners for CFAP97 Gene

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CFAP97 Gene

Orthologs for CFAP97 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CFAP97 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia KIAA1430 35
  • 79.17 (n)
  • 73.52 (a)
KIAA1430 36
  • 74 (a)
OneToOne
dog
(Canis familiaris)
Mammalia KIAA1430 35
  • 84.97 (n)
  • 79.19 (a)
KIAA1430 36
  • 79 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 4933411K20Rik 35
  • 78.45 (n)
  • 73.4 (a)
Cfap97 16
4933411K20Rik 36
  • 70 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia KIAA1430 35
  • 96.59 (n)
  • 95.64 (a)
KIAA1430 36
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1307325 35
  • 77.13 (n)
  • 73.49 (a)
oppossum
(Monodelphis domestica)
Mammalia KIAA1430 36
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1430 36
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1430 36
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1430 36
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1430 35
  • 57.08 (n)
  • 47.49 (a)
zebrafish
(Danio rerio)
Actinopterygii zgc:85910 36
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 28 (a)
OneToOne
Species with no ortholog for CFAP97:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFAP97 Gene

ENSEMBL:
Gene Tree for CFAP97 (if available)
TreeFam:
Gene Tree for CFAP97 (if available)

Paralogs for CFAP97 Gene

Pseudogenes.org Pseudogenes for CFAP97 Gene

genes like me logo Genes that share paralogs with CFAP97: view

No data available for Paralogs for CFAP97 Gene

Variants for CFAP97 Gene

Sequence variations from dbSNP and Humsavar for CFAP97 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1133657 - 185,190,485(-) GTACT(A/G)CACCA reference, missense
rs6820332 - 185,170,333(+) agagc(A/G)agata intron-variant, reference, missense
rs1534141 -- 185,197,931(+) ctact(C/T)cagcg intron-variant
rs1969456 -- 185,196,343(+) GTGGC(A/G)CGTGC intron-variant
rs1534140 -- 185,196,008(+) GAATA(C/T)CTTTG intron-variant

Variation tolerance for CFAP97 Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.27; 76.42% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CFAP97 Gene

Disorders for CFAP97 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CFAP97 Gene - From: DISEASES

Disorder Aliases PubMed IDs
primary ciliary dyskinesia
  • kartagener syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CFAP97

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CFAP97
genes like me logo Genes that share disorders with CFAP97: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CFAP97 Gene

Publications for CFAP97 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T. … Ohara O. (DNA Res. 2000) 2 3 4 67
  2. hemingway is required for sperm flagella assembly and ciliary motility in Drosophila. (PMID: 24554765) Soulavie F. … Durand B. (Mol. Biol. Cell 2014) 2 3
  3. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein M.Y. … Mann M. (Cell 2015) 3
  4. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta G.D. … Pelletier L. (Cell 2015) 3
  5. Systematic analysis of human protein complexes identifies chromosome segregation proteins. (PMID: 20360068) Hutchins J.R. … Peters J.M. (Science 2010) 3

Products for CFAP97 Gene

Sources for CFAP97 Gene

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