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Aliases for CFAP97 Gene

Aliases for CFAP97 Gene

  • Cilia And Flagella Associated Protein 97 2 3 5
  • KIAA1430 2 3 4
  • Cilia- And Flagella-Associated Protein 97 3
  • Hmw 3

External Ids for CFAP97 Gene

Previous HGNC Symbols for CFAP97 Gene

  • KIAA1430

Summaries for CFAP97 Gene

GeneCards Summary for CFAP97 Gene

CFAP97 (Cilia And Flagella Associated Protein 97) is a Protein Coding gene.

Additional gene information for CFAP97 Gene

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFAP97 Gene

Genomics for CFAP97 Gene

Regulatory Elements for CFAP97 Gene

Enhancers for CFAP97 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH04H184338 1.8 FANTOM5 Ensembl ENCODE dbSUPER 25.6 +869.9 869861 1 HDGF ATF1 YY1 ZNF766 ELK1 EGR1 CAVIN1 ZBTB11 CEBPB USF2 PRIMPOL CFAP97 TRAPPC11 CDKN2AIP IRF2 RNU6-1053P SNX25 MYL12BP2 ACSL1 LINC02363
GH04H185912 1.2 Ensembl ENCODE 22.9 -704.8 -704800 3 PKNOX1 ARNT FEZF1 ZNF2 GLIS2 ATF7 SP3 TSHZ1 ZNF488 ZNF662 CFAP97 LOC101928929 SLC25A5P6 RNU6-1055P LINC02436 ENSG00000249520 MRPS36P2 ORAOV1P1 SORBS2
GH04H185235 1.1 Ensembl ENCODE 24.8 -26.4 -26399 1 HDAC1 ELF3 PKNOX1 FOXA2 ATF1 INSM2 ARID4B RARA ZNF121 GATA2 CFAP97 SNX25 LOC105377591
GH04H185303 1.4 Ensembl ENCODE dbSUPER 18.9 -96.9 -96919 5 HDGF RB1 BATF RAD21 SCRT2 ZNF143 FOS ETV6 RUNX3 IKZF2 CFAP97 LRP2BP SNX25 LOC105377591
GH04H185201 1.1 ENCODE 18.3 +6.1 6061 4 PKNOX1 FOXA2 MLX ARNT ARID4B SIN3A FEZF1 DMAP1 YY1 SLC30A9 PRIMPOL CFAP97 SNX25 GC04P185149
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CFAP97 on UCSC Golden Path with GeneCards custom track

Promoters for CFAP97 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000177018 -696 2401 PKNOX1 ATF1 MLX ARNT ARID4B SIN3A GLIS2 ZNF143 ZNF207 ATF7

Genomic Location for CFAP97 Gene

Chromosome:
4
Start:
185,151,723 bp from pter
End:
185,209,504 bp from pter
Size:
57,782 bases
Orientation:
Minus strand

Genomic View for CFAP97 Gene

Genes around CFAP97 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CFAP97 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CFAP97 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFAP97 Gene

Proteins for CFAP97 Gene

  • Protein details for CFAP97 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9P2B7-CFA97_HUMAN
    Recommended name:
    Cilia- and flagella-associated protein 97
    Protein Accession:
    Q9P2B7
    Secondary Accessions:
    • B3KRP7
    • D3DP60
    • Q05CU1
    • Q4W5M4
    • Q8N6E7
    • Q9UF45

    Protein attributes for CFAP97 Gene

    Size:
    532 amino acids
    Molecular mass:
    59475 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAH20772.1; Type=Frameshift; Positions=50; Evidence={ECO:0000305}; Sequence=AAH20772.1; Type=Miscellaneous discrepancy; Note=Contaminating sequence. Potential poly-A sequence.; Evidence={ECO:0000305}; Sequence=AAY40976.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CFAP97 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CFAP97 Gene

Post-translational modifications for CFAP97 Gene

  • Ubiquitination at Lys375
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CFAP97 Gene

Domains & Families for CFAP97 Gene

Gene Families for CFAP97 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CFAP97 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CFAP97 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9P2B7

UniProtKB/Swiss-Prot:

CFA97_HUMAN :
  • Belongs to the CFAP97 family.
Family:
  • Belongs to the CFAP97 family.
genes like me logo Genes that share domains with CFAP97: view

Function for CFAP97 Gene

Phenotypes From GWAS Catalog for CFAP97 Gene

Phenotypes for CFAP97 Gene

GenomeRNAi human phenotypes for CFAP97:
genes like me logo Genes that share phenotypes with CFAP97: view

Animal Model Products

CRISPR Products

miRNA for CFAP97 Gene

miRTarBase miRNAs that target CFAP97

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CFAP97
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CFAP97 Gene

Localization for CFAP97 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CFAP97 gene
Compartment Confidence
nucleus 5
cytosol 4
plasma membrane 3
extracellular 2
cytoskeleton 2
endoplasmic reticulum 1

Subcellular locations from the

Human Protein Atlas (HPA)
  • Cytosol (3)
  • Nucleoli (3)
  • Plasma membrane (3)
See all subcellular structures

No data available for Subcellular locations from UniProtKB/Swiss-Prot and Gene Ontology (GO) - Cellular Components for CFAP97 Gene

Pathways & Interactions for CFAP97 Gene

SuperPathways for CFAP97 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CFAP97 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CFAP97 Gene

Drugs & Compounds for CFAP97 Gene

No Compound Related Data Available

Transcripts for CFAP97 Gene

mRNA/cDNA for CFAP97 Gene

(6) REFSEQ mRNAs :
(5) Ensembl transcripts including schematic representations, and UCSC links where relevant :

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CFAP97
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CFAP97 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4 ^ 5 ^ 6
SP1: - -
SP2:

Relevant External Links for CFAP97 Gene

GeneLoc Exon Structure for
CFAP97
ECgene alternative splicing isoforms for
CFAP97

Expression for CFAP97 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CFAP97 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CFAP97 Gene

This gene is overexpressed in Monocytes (36.5), Prostate (16.3), and Testis (16.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CFAP97 Gene



Protein tissue co-expression partners for CFAP97 Gene

NURSA nuclear receptor signaling pathways regulating expression of CFAP97 Gene:

CFAP97

Evidence on tissue expression from TISSUES for CFAP97 Gene

  • Liver(2.4)
  • Nervous system(2.3)
  • Kidney(2.2)
  • Lung(2.2)
  • Blood(2.1)
  • Heart(2.1)
  • Intestine(2)
genes like me logo Genes that share expression patterns with CFAP97: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CFAP97 Gene

Orthologs for CFAP97 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CFAP97 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia KIAA1430 33 34
  • 96.59 (n)
dog
(Canis familiaris)
Mammalia KIAA1430 33 34
  • 84.97 (n)
cow
(Bos Taurus)
Mammalia KIAA1430 33 34
  • 79.17 (n)
mouse
(Mus musculus)
Mammalia 4933411K20Rik 33 34
  • 78.45 (n)
Cfap97 16
rat
(Rattus norvegicus)
Mammalia RGD1307325 33
  • 77.13 (n)
oppossum
(Monodelphis domestica)
Mammalia KIAA1430 34
  • 59 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia KIAA1430 34
  • 33 (a)
OneToOne
chicken
(Gallus gallus)
Aves KIAA1430 34
  • 38 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia KIAA1430 34
  • 49 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia kiaa1430 33
  • 57.08 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:85910 34
  • 33 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 34
  • 28 (a)
OneToOne
Species where no ortholog for CFAP97 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFAP97 Gene

ENSEMBL:
Gene Tree for CFAP97 (if available)
TreeFam:
Gene Tree for CFAP97 (if available)

Paralogs for CFAP97 Gene

Pseudogenes.org Pseudogenes for CFAP97 Gene

genes like me logo Genes that share paralogs with CFAP97: view

No data available for Paralogs for CFAP97 Gene

Variants for CFAP97 Gene

Sequence variations from dbSNP and Humsavar for CFAP97 Gene

SNP ID Clin Chr 04 pos Sequence Context AA Info Type
rs1000031449 -- 185,161,083(+) AAGTA(C/T)AGTAA utr-variant-3-prime
rs1000072148 -- 185,167,174(+) AAAAA(A/C)CAACA intron-variant
rs1000094375 -- 185,193,301(+) GAGAA(G/T)CCATG intron-variant
rs1000104312 -- 185,182,784(+) ATTTT(A/G)TAGTT intron-variant
rs1000277135 -- 185,187,553(+) GAGAA(A/G)CAGAG intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CFAP97 Gene

Variant ID Type Subtype PubMed ID
esv28748 CNV loss 19812545
esv3603487 CNV loss 21293372
esv989960 CNV insertion 20482838
nsv461859 CNV loss 19166990
nsv596369 CNV loss 21841781
nsv822883 CNV gain 20364138

Variation tolerance for CFAP97 Gene

Residual Variation Intolerance Score: 74% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.27; 76.42% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CFAP97 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CFAP97

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CFAP97 Gene

Disorders for CFAP97 Gene

Relevant External Links for CFAP97

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CFAP97

No disorders were found for CFAP97 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CFAP97 Gene

Publications for CFAP97 Gene

  1. Prediction of the coding sequences of unidentified human genes. XVI. The complete sequences of 150 new cDNA clones from brain which code for large proteins in vitro. (PMID: 10718198) Nagase T … Ohara O (DNA research : an international journal for rapid publication of reports on genes and genomes 2000) 2 3 4 60
  2. A Dynamic Protein Interaction Landscape of the Human Centrosome-Cilium Interface. (PMID: 26638075) Gupta GD … Pelletier L (Cell 2015) 2 3 60
  3. hemingway is required for sperm flagella assembly and ciliary motility in Drosophila. (PMID: 24554765) Soulavie F … Durand B (Molecular biology of the cell 2014) 2 3 60
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  5. A human interactome in three quantitative dimensions organized by stoichiometries and abundances. (PMID: 26496610) Hein MY … Mann M (Cell 2015) 3 60

Products for CFAP97 Gene

Sources for CFAP97 Gene

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