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Aliases for CFAP77 Gene

Aliases for CFAP77 Gene

  • Cilia And Flagella Associated Protein 77 2 3 5
  • C9orf171 3 4
  • Chromosome 9 Open Reading Frame 171 2
  • Uncharacterized Protein C9orf171 3

External Ids for CFAP77 Gene

Previous HGNC Symbols for CFAP77 Gene

  • C9orf171

Previous GeneCards Identifiers for CFAP77 Gene

  • GC09P132420
  • GC09P132428

Summaries for CFAP77 Gene

GeneCards Summary for CFAP77 Gene

CFAP77 (Cilia And Flagella Associated Protein 77) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFAP77 Gene

Genomics for CFAP77 Gene

Regulatory Elements for CFAP77 Gene

Enhancers for CFAP77 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CFAP77 on UCSC Golden Path with GeneCards custom track

Promoters for CFAP77 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CFAP77 Gene

Chromosome:
9
Start:
132,410,043 bp from pter
End:
132,573,319 bp from pter
Size:
163,277 bases
Orientation:
Plus strand

Genomic View for CFAP77 Gene

Genes around CFAP77 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CFAP77 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CFAP77 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFAP77 Gene

Proteins for CFAP77 Gene

  • Protein details for CFAP77 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6ZQR2-CI171_HUMAN
    Recommended name:
    Uncharacterized protein C9orf171
    Protein Accession:
    Q6ZQR2
    Secondary Accessions:
    • Q147X1

    Protein attributes for CFAP77 Gene

    Size:
    320 amino acids
    Molecular mass:
    36499 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CFAP77 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CFAP77 Gene

Post-translational modifications for CFAP77 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CFAP77 Gene

No data available for DME Specific Peptides for CFAP77 Gene

Domains & Families for CFAP77 Gene

Protein Domains for CFAP77 Gene

InterPro:
ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CFAP77: view

No data available for Gene Families , Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CFAP77 Gene

Function for CFAP77 Gene

Gene Ontology (GO) - Molecular Function for CFAP77 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CFAP77: view

Phenotypes for CFAP77 Gene

GenomeRNAi human phenotypes for CFAP77:
genes like me logo Genes that share phenotypes with CFAP77: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CFAP77 Gene

Localization for CFAP77 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CFAP77 Gene

Pathways & Interactions for CFAP77 Gene

SuperPathways for CFAP77 Gene

No Data Available

Interacting Proteins for CFAP77 Gene

STRING Interaction Network Preview (showing 1 interactants - click image to see details)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000343290%0d%0a9606.ENSP00000346440%0d%0a
Selected Interacting proteins: ENSP00000343290 Q6ZQR2-CI171_HUMAN for CFAP77 Gene via STRING UniProtKB IID

Gene Ontology (GO) - Biological Process for CFAP77 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CFAP77 Gene

Drugs & Compounds for CFAP77 Gene

No Compound Related Data Available

Transcripts for CFAP77 Gene

mRNA/cDNA for CFAP77 Gene

(5) REFSEQ mRNAs :
(8) Selected AceView cDNA sequences:
(3) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CFAP77 Gene

No ASD Table

Relevant External Links for CFAP77 Gene

GeneLoc Exon Structure for
CFAP77
ECgene alternative splicing isoforms for
CFAP77

Expression for CFAP77 Gene

NURSA nuclear receptor signaling pathways regulating expression of CFAP77 Gene:

CFAP77
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CFAP77 Gene

Orthologs for CFAP77 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CFAP77 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C11H9orf171 34
  • 89.91 (n)
  • 91.9 (a)
C9orf171 35
  • 82 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9H9orf171 34
  • 89.24 (n)
  • 90.07 (a)
C9orf171 35
  • 63 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700101E01Rik 34
  • 84.97 (n)
  • 88.11 (a)
Cfap77 16
1700101E01Rik 35
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf171 34
  • 99.48 (n)
  • 100 (a)
C9orf171 35
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1564114 34
  • 83.86 (n)
  • 85.16 (a)
oppossum
(Monodelphis domestica)
Mammalia C9orf171 35
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf171 35
  • 37 (a)
OneToOne
chicken
(Gallus gallus)
Aves C17H9ORF171 34
  • 61.95 (n)
  • 52.79 (a)
C9orf171 35
  • 50 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia LOC100491608 34
  • 59.04 (n)
  • 49.25 (a)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-215c18.4 34
  • 50.21 (n)
  • 41.7 (a)
C5H9orf171 35
  • 39 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4401 35
  • 42 (a)
OneToOne
Species where no ortholog for CFAP77 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFAP77 Gene

ENSEMBL:
Gene Tree for CFAP77 (if available)
TreeFam:
Gene Tree for CFAP77 (if available)

Paralogs for CFAP77 Gene

No data available for Paralogs for CFAP77 Gene

Variants for CFAP77 Gene

Sequence variations from dbSNP and Humsavar for CFAP77 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs7855260 -- 132,547,419(+) TGCCT(A/G)TAAGT intron-variant
rs7857471 -- 132,550,269(+) GTTTT(C/T)TGTTG intron-variant
rs7858830 -- 132,555,067(+) TAAAA(C/G)TAGAG intron-variant
rs7859313 -- 132,554,711(+) TACAA(A/C)TACTG intron-variant
rs7859389 -- 132,544,732(+) cttaa(A/G)tgatc intron-variant, downstream-variant-500B

Structural Variations from Database of Genomic Variants (DGV) for CFAP77 Gene

Variant ID Type Subtype PubMed ID
dgv1383e199 CNV deletion 23128226
dgv4153n106 CNV deletion 24896259
esv1000676 CNV deletion 20482838
esv1002280 CNV deletion 20482838
esv1509495 CNV deletion 17803354
esv1524647 CNV insertion 17803354
esv2070104 CNV deletion 18987734
esv2664760 CNV deletion 23128226
esv2667814 CNV deletion 23128226
esv2739131 CNV deletion 23290073
esv2739132 CNV deletion 23290073
esv2739133 CNV deletion 23290073
esv2739134 CNV deletion 23290073
esv2739135 CNV deletion 23290073
esv2739136 CNV deletion 23290073
esv3371 CNV loss 18987735
esv3545548 CNV deletion 23714750
esv3545549 CNV deletion 23714750
esv3545550 CNV deletion 23714750
esv3545551 CNV deletion 23714750
esv3573406 CNV loss 25503493
esv3621913 CNV loss 21293372
esv3621916 CNV loss 21293372
esv5190 CNV loss 18987735
esv5887 CNV loss 19470904
nsv1040162 CNV gain 25217958
nsv1124485 CNV deletion 24896259
nsv1139374 CNV deletion 24896259
nsv1141036 CNV deletion 24896259
nsv1146630 CNV deletion 26484159
nsv415449 CNV deletion 16902084
nsv415812 CNV deletion 16902084
nsv416344 CNV deletion 16902084
nsv516741 CNV loss 19592680
nsv520491 CNV gain 19592680
nsv6741 CNV deletion 18451855
nsv6744 CNV insertion 18451855

Variation tolerance for CFAP77 Gene

Residual Variation Intolerance Score: 77.9% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.92; 89.82% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CFAP77 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CFAP77

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CFAP77 Gene

Disorders for CFAP77 Gene

Relevant External Links for CFAP77

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CFAP77
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CFAP77

No disorders were found for CFAP77 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CFAP77 Gene

Publications for CFAP77 Gene

  1. The lung-specific proteome defined by integration of transcriptomics and antibody-based profiling. (PMID: 25169055) Lindskog C. … Micke P. (FASEB J. 2014) 2 3 65
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3 65
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3 65
  4. Novel genetic loci identified for the pathophysiology of childhood obesity in the Hispanic population. (PMID: 23251661) Comuzzie A.G. … Butte N.F. (PLoS ONE 2012) 3 65
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3 65

Products for CFAP77 Gene

Sources for CFAP77 Gene

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