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Aliases for CFAP74 Gene

Aliases for CFAP74 Gene

  • Cilia And Flagella Associated Protein 74 2 3 5
  • KIAA1751 2 3 4
  • C1orf222 3 4
  • Chromosome 1 Open Reading Frame 222 2

External Ids for CFAP74 Gene

Previous HGNC Symbols for CFAP74 Gene

  • C1orf222
  • KIAA1751

Summaries for CFAP74 Gene

GeneCards Summary for CFAP74 Gene

CFAP74 (Cilia And Flagella Associated Protein 74) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CFAP74 Gene

  • As part of the central apparatus of the cilium axoneme may play a role in cilium movement.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFAP74 Gene

Genomics for CFAP74 Gene

Regulatory Elements for CFAP74 Gene

Enhancers for CFAP74 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CFAP74 on UCSC Golden Path with GeneCards custom track

Genomic Location for CFAP74 Gene

1,921,951 bp from pter
2,003,837 bp from pter
81,887 bases
Minus strand

Genomic View for CFAP74 Gene

Genes around CFAP74 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CFAP74 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CFAP74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFAP74 Gene

Proteins for CFAP74 Gene

  • Protein details for CFAP74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cilia- and flagella-associated protein 74
    Protein Accession:
    Secondary Accessions:
    • A4VCI2
    • H7C4E1
    • Q5T2D9
    • Q5T2E0
    • Q69YW0
    • Q6ZSJ4

    Protein attributes for CFAP74 Gene

    1584 amino acids
    Molecular mass:
    178589 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAI14927.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAB21842.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAH10703.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for CFAP74 Gene


neXtProt entry for CFAP74 Gene

Proteomics data for CFAP74 Gene at MOPED

Post-translational modifications for CFAP74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CFAP74 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CFAP74 Gene

Domains & Families for CFAP74 Gene

Protein Domains for CFAP74 Gene


Suggested Antigen Peptide Sequences for CFAP74 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CFAP74 family.
  • Belongs to the CFAP74 family.
genes like me logo Genes that share domains with CFAP74: view

No data available for Gene Families for CFAP74 Gene

Function for CFAP74 Gene

Molecular function for CFAP74 Gene

UniProtKB/Swiss-Prot Function:
As part of the central apparatus of the cilium axoneme may play a role in cilium movement.
genes like me logo Genes that share phenotypes with CFAP74: view

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CFAP74 Gene

Localization for CFAP74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFAP74 Gene

Cytoplasm, cytoskeleton, cilium axoneme.

Gene Ontology (GO) - Cellular Components for CFAP74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
genes like me logo Genes that share ontologies with CFAP74: view

No data available for Subcellular locations from COMPARTMENTS for CFAP74 Gene

Pathways & Interactions for CFAP74 Gene

SuperPathways for CFAP74 Gene

No Data Available

Interacting Proteins for CFAP74 Gene

Gene Ontology (GO) - Biological Process for CFAP74 Gene


No data available for Pathways by source and SIGNOR curated interactions for CFAP74 Gene

Drugs & Compounds for CFAP74 Gene

No Compound Related Data Available

Transcripts for CFAP74 Gene

mRNA/cDNA for CFAP74 Gene

(12) REFSEQ mRNAs :
(5) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CFAP74 Gene

No ASD Table

Relevant External Links for CFAP74 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CFAP74 Gene

mRNA expression in normal human tissues for CFAP74 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CFAP74 Gene

This gene is overexpressed in Amniocyte (42.4) and Bone marrow mesenchymal stem cell (25.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CFAP74 Gene

genes like me logo Genes that share expression patterns with CFAP74: view

Primer Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CFAP74 Gene

Orthologs for CFAP74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CFAP74 Gene

Organism Taxonomy Gene Similarity Type Details
(Canis familiaris)
Mammalia KIAA1751 35
  • 76.36 (n)
  • 67.52 (a)
C1orf222 36
  • 73 (a)
(Mus musculus)
Mammalia 2010015L04Rik 35
  • 73.62 (n)
  • 66.91 (a)
Cfap74 16
(Rattus norvegicus)
Mammalia LOC100362748 35
  • 73.9 (n)
  • 68.56 (a)
(Bos Taurus)
Mammalia C1orf222 36
  • 72 (a)
(Ornithorhynchus anatinus)
Mammalia C1orf222 36
  • 49 (a)
(Gallus gallus)
Aves KIAA1751 35
  • 54.4 (n)
  • 44.72 (a)
C1orf222 36
  • 38 (a)
(Anolis carolinensis)
Reptilia C1orf222 36
  • 40 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf222 35
  • 53.69 (n)
  • 44.28 (a)
(Danio rerio)
Actinopterygii si:dkeyp-87a12.1 35
  • 48.02 (n)
  • 35.2 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 11 (a)
-- 36
  • 29 (a)
Species with no ortholog for CFAP74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFAP74 Gene

Gene Tree for CFAP74 (if available)
Gene Tree for CFAP74 (if available)

Paralogs for CFAP74 Gene

No data available for Paralogs for CFAP74 Gene

Variants for CFAP74 Gene

Sequence variations from dbSNP and Humsavar for CFAP74 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs13303083 - 1,988,892(-) ACACA(G/T)CAGGT reference, missense, utr-variant-5-prime
rs16824588 - 1,968,793(-) AGATC(A/G)TCAGT reference, missense
rs3820011 - 1,956,754(-) ACTTC(A/G/T)GCAGC reference, missense
rs745630 -- 1,923,278(+) CCCTG(C/T)CCTGC intron-variant
rs752965 -- 1,924,659(+) GCACA(C/T)GTGGC intron-variant

Variation tolerance for CFAP74 Gene

Gene Damage Index Score: 19.45; 98.86% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot , Structural Variations from Database of Genomic Variants (DGV) and Relevant External Links for CFAP74 Gene

Disorders for CFAP74 Gene

Relevant External Links for CFAP74

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CFAP74 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CFAP74 Gene

Publications for CFAP74 Gene

  1. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 3 4 67
  2. The BioPlex Network: A Systematic Exploration of the Human Interactome. (PMID: 26186194) Huttlin E.L. … Gygi S.P. (Cell 2015) 3
  3. The BTB and CNC homology 1 (BACH1) target genes are involved in the oxidative stress response and in control of the cell cycle. (PMID: 21555518) Warnatz H.J. … Yaspo M.L. (J. Biol. Chem. 2011) 3
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3

Products for CFAP74 Gene

Sources for CFAP74 Gene