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Aliases for CFAP74 Gene

Aliases for CFAP74 Gene

  • Cilia And Flagella Associated Protein 74 2 3
  • KIAA1751 2 3 4
  • C1orf222 3 4
  • Cilia- And Flagella-Associated Protein 74 3
  • Chromosome 1 Open Reading Frame 222 2

External Ids for CFAP74 Gene

Previous HGNC Symbols for CFAP74 Gene

  • C1orf222
  • KIAA1751

Summaries for CFAP74 Gene

GeneCards Summary for CFAP74 Gene

CFAP74 (Cilia And Flagella Associated Protein 74) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CFAP74 Gene

  • As part of the central apparatus of the cilium axoneme may play a role in cilium movement.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFAP74 Gene

Genomics for CFAP74 Gene

Genomic Location for CFAP74 Gene

Start:
1,921,951 bp from pter
End:
2,003,837 bp from pter
Size:
81,887 bases
Orientation:
Minus strand

Genomic View for CFAP74 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CFAP74 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFAP74 Gene

No data available for Regulatory Elements for CFAP74 Gene

Proteins for CFAP74 Gene

  • Protein details for CFAP74 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9C0B2-CFA74_HUMAN
    Recommended name:
    Cilia- and flagella-associated protein 74
    Protein Accession:
    Q9C0B2
    Secondary Accessions:
    • A4VCI2
    • H7C4E1
    • Q5T2D9
    • Q5T2E0
    • Q69YW0
    • Q6ZSJ4

    Protein attributes for CFAP74 Gene

    Size:
    1584 amino acids
    Molecular mass:
    178589 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAI14927.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=BAB21842.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305}; Sequence=CAH10703.1; Type=Miscellaneous discrepancy; Note=Probable cloning artifact.; Evidence={ECO:0000305};

    Alternative splice isoforms for CFAP74 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CFAP74 Gene

Proteomics data for CFAP74 Gene at MOPED

Post-translational modifications for CFAP74 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CFAP74 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CFAP74 Gene

Domains for CFAP74 Gene

Protein Domains for CFAP74 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q9C0B2

UniProtKB/Swiss-Prot:

CFA74_HUMAN :
  • Q9C0B2
Family:
  • Belongs to the CFAP74 family.
genes like me logo Genes that share domains with CFAP74: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CFAP74 Gene

Function for CFAP74 Gene

Molecular function for CFAP74 Gene

UniProtKB/Swiss-Prot Function: As part of the central apparatus of the cilium axoneme may play a role in cilium movement.

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CFAP74 Gene

Localization for CFAP74 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFAP74 Gene

Cytoplasm, cytoskeleton, cilium axoneme.

Gene Ontology (GO) - Cellular Components for CFAP74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005856 cytoskeleton IEA --
GO:0005930 axoneme ISS --
genes like me logo Genes that share ontologies with CFAP74: view

No data available for Subcellular locations from COMPARTMENTS for CFAP74 Gene

Pathways for CFAP74 Gene

SuperPathways for CFAP74 Gene

No Data Available

Interacting Proteins for CFAP74 Gene

Gene Ontology (GO) - Biological Process for CFAP74 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0035082 axoneme assembly ISS --
genes like me logo Genes that share ontologies with CFAP74: view

No data available for Pathways by source for CFAP74 Gene

Transcripts for CFAP74 Gene

mRNA/cDNA for CFAP74 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CFAP74 Gene

No ASD Table

Relevant External Links for CFAP74 Gene

GeneLoc Exon Structure for
CFAP74
ECgene alternative splicing isoforms for
CFAP74

Expression for CFAP74 Gene

mRNA expression in normal human tissues for CFAP74 Gene

Integrated Proteomics: protein expression from ProteomicsDB and MOPED for CFAP74 Gene

genes like me logo Genes that share expressions with CFAP74: view

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CFAP74 Gene

Orthologs for CFAP74 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CFAP74 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C1orf222 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C1orf222 36
  • 73 (a)
OneToOne
KIAA1751 35
  • 76.36 (n)
  • 67.52 (a)
mouse
(Mus musculus)
Mammalia 2010015L04Rik 35
  • 73.62 (n)
  • 66.91 (a)
2010015L04Rik 16
platypus
(Ornithorhynchus anatinus)
Mammalia C1orf222 36
  • 49 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia LOC100362748 35
  • 73.9 (n)
  • 68.56 (a)
chicken
(Gallus gallus)
Aves C1orf222 36
  • 38 (a)
OneToOne
KIAA1751 35
  • 54.4 (n)
  • 44.72 (a)
lizard
(Anolis carolinensis)
Reptilia C1orf222 36
  • 40 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c1orf222 35
  • 53.69 (n)
  • 44.28 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkeyp-87a12.1 35
  • 48.02 (n)
  • 35.2 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 11 (a)
OneToMany
-- 36
  • 29 (a)
OneToMany
Species with no ortholog for CFAP74:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chimpanzee (Pan troglodytes)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFAP74 Gene

ENSEMBL:
Gene Tree for CFAP74 (if available)
TreeFam:
Gene Tree for CFAP74 (if available)

Paralogs for CFAP74 Gene

No data available for Paralogs for CFAP74 Gene

Variants for CFAP74 Gene

Sequence variations from dbSNP and Humsavar for CFAP74 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs745630 -- 1,923,278(+) CCCTG(C/T)CCTGC intron-variant
rs752965 -- 1,924,659(+) GCACA(C/T)GTGGC intron-variant
rs752966 -- 1,924,788(+) CAGGG(C/T)GCCTG intron-variant
rs752967 -- 1,924,931(+) GCCAG(A/G)CGGAG intron-variant
rs941530 -- 1,926,870(+) CACCC(C/T)GTTCT intron-variant

Relevant External Links for CFAP74 Gene

HapMap Linkage Disequilibrium report
CFAP74

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CFAP74 Gene

Disorders for CFAP74 Gene

No disorders were found for CFAP74 Gene.

No data available for UniProtKB/Swiss-Prot for CFAP74 Gene

Publications for CFAP74 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  3. The full-ORF clone resource of the German cDNA consortium. (PMID: 17974005) Bechtel S. … Schupp I. (BMC Genomics 2007) 3 4
  4. Prediction of the coding sequences of unidentified human genes. XIX. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro. (PMID: 11214970) Nagase T. … Ohara O. (DNA Res. 2000) 3 4
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CFAP74 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CFAP74
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CFAP74
    • Block miRNA regulation of CFAP74 using miScript Target Protectors

    Sources for CFAP74 Gene

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