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Aliases for CFAP73 Gene

Aliases for CFAP73 Gene

  • Cilia And Flagella Associated Protein 73 2 3 5
  • Coiled-Coil Domain-Containing Protein 42B 3 4
  • Coiled-Coil Domain Containing 42B 2 3
  • CCDC42B 3 4
  • Cilia- And Flagella-Associated Protein 73 3
  • MIA2 3

External Ids for CFAP73 Gene

Previous HGNC Symbols for CFAP73 Gene

  • CCDC42B

Summaries for CFAP73 Gene

GeneCards Summary for CFAP73 Gene

CFAP73 (Cilia And Flagella Associated Protein 73) is a Protein Coding gene. An important paralog of this gene is CCDC42.

UniProtKB/Swiss-Prot for CFAP73 Gene

  • May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFAP73 Gene

Genomics for CFAP73 Gene

Regulatory Elements for CFAP73 Gene

Enhancers for CFAP73 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH12F113064 1.4 FANTOM5 Ensembl ENCODE 11.5 -83.7 -83709 1.5 HDGF ZNF48 ZSCAN9 EGR1 ZNF366 ZNF143 MIXL1 EGR2 SMARCC1 KLF11 ENSG00000201208 DDX54 RITA1 CFAP73 DTX1 GC12P113070
GH12F113069 0.9 FANTOM5 Ensembl ENCODE 11.5 -78.4 -78448 3.1 TBP TBL1XR1 WRNIP1 INSM2 ZNF48 ZBTB40 RARA YY1 EGR1 ELK1 ENSG00000201208 DDX54 RITA1 CFAP73 DTX1 PLBD2 SDSL GC12P113070 RASAL1
GH12F113088 1 Ensembl ENCODE 11.5 -59.4 -59387 2.0 HDGF BCOR USF1 MAX EBF1 ZBTB40 ZNF23 POLR2A CHD2 NRF1 DTX1 ENSG00000201208 RITA1 DDX54 CFAP73 RASAL1 GC12P113070
GH12F113086 1.4 FANTOM5 Ensembl ENCODE 11.3 -61.9 -61903 2.2 HDGF BCOR CTCF ZMYM3 MAX EBF1 SCRT2 CHD2 ZNF263 SMARCA5 DTX1 CFAP73 RASAL1 GC12P113070
GH12F113082 0.7 ENCODE 11.3 -66.3 -66312 1.1 TBP CBX5 NBN ZMYM3 MLLT1 EBF1 TBX21 DTX1 CFAP73 GC12P113070 RASAL1
- Elite enhancer/Elite enhancer-gene association Download Table
Download GeneHancer data dump

Enhancers around CFAP73 on UCSC Golden Path with GeneCards custom track

Genomic Location for CFAP73 Gene

Chromosome:
12
Start:
113,149,181 bp from pter
End:
113,159,276 bp from pter
Size:
10,096 bases
Orientation:
Plus strand

Genomic View for CFAP73 Gene

Genes around CFAP73 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CFAP73 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CFAP73 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFAP73 Gene

Proteins for CFAP73 Gene

  • Protein details for CFAP73 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    A6NFT4-CFA73_HUMAN
    Recommended name:
    Cilia- and flagella-associated protein 73
    Protein Accession:
    A6NFT4

    Protein attributes for CFAP73 Gene

    Size:
    308 amino acids
    Molecular mass:
    35914 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CFAP73 Gene

Post-translational modifications for CFAP73 Gene

No Post-translational modifications

Other Protein References for CFAP73 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CFAP73 Gene

Domains & Families for CFAP73 Gene

Protein Domains for CFAP73 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CFAP73 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

A6NFT4

UniProtKB/Swiss-Prot:

CFA73_HUMAN :
  • Belongs to the CFAP73 family.
Family:
  • Belongs to the CFAP73 family.
genes like me logo Genes that share domains with CFAP73: view

No data available for Gene Families for CFAP73 Gene

Function for CFAP73 Gene

Molecular function for CFAP73 Gene

UniProtKB/Swiss-Prot Function:
May play a role in ciliary/flagellar motility by regulating the assembly and the activity of axonemal inner dynein arm.

Gene Ontology (GO) - Molecular Function for CFAP73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0070840 dynein complex binding ISS --
genes like me logo Genes that share ontologies with CFAP73: view

Phenotypes for CFAP73 Gene

GenomeRNAi human phenotypes for CFAP73:
genes like me logo Genes that share phenotypes with CFAP73: view

Animal Model Products

miRNA for CFAP73 Gene

miRTarBase miRNAs that target CFAP73

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CFAP73 Gene

Localization for CFAP73 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFAP73 Gene

Cytoplasm, cytoskeleton, cilium axoneme.

Gene Ontology (GO) - Cellular Components for CFAP73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0005856 cytoskeleton IEA --
GO:0005929 cilium IEA --
GO:0031514 motile cilium ISS --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with CFAP73: view

No data available for Subcellular locations from COMPARTMENTS for CFAP73 Gene

Pathways & Interactions for CFAP73 Gene

SuperPathways for CFAP73 Gene

No Data Available

Interacting Proteins for CFAP73 Gene

Selected Interacting proteins: A6NFT4-CFA73_HUMAN for CFAP73 Gene via IID

Symbol External ID(s) Details
NFKB1

Gene Ontology (GO) - Biological Process for CFAP73 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003341 cilium movement ISS --
GO:0036159 inner dynein arm assembly ISS --
GO:2000574 regulation of microtubule motor activity ISS --
genes like me logo Genes that share ontologies with CFAP73: view

No data available for Pathways by source and SIGNOR curated interactions for CFAP73 Gene

Transcripts for CFAP73 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CFAP73 Gene

No ASD Table

Relevant External Links for CFAP73 Gene

GeneLoc Exon Structure for
CFAP73
ECgene alternative splicing isoforms for
CFAP73

Expression for CFAP73 Gene

NURSA nuclear receptor signaling pathways regulating expression of CFAP73 Gene:

CFAP73
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CFAP73 Gene

Orthologs for CFAP73 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CFAP73 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC42B 34 35
  • 99.57 (n)
cow
(Bos Taurus)
Mammalia CCDC42B 34 35
  • 83.12 (n)
dog
(Canis familiaris)
Mammalia CCDC42B 34 35
  • 82.44 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc42b 34
  • 68.87 (n)
mouse
(Mus musculus)
Mammalia Ccdc42b 34 35
  • 67.97 (n)
Cfap73 16
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC42B 35
  • 38 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC42B 34 35
  • 55.21 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC42B 35
  • 39 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ccdc42b 35
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.4208 35
  • 39 (a)
OneToMany
Species where no ortholog for CFAP73 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFAP73 Gene

ENSEMBL:
Gene Tree for CFAP73 (if available)
TreeFam:
Gene Tree for CFAP73 (if available)

Paralogs for CFAP73 Gene

Paralogs for CFAP73 Gene

genes like me logo Genes that share paralogs with CFAP73: view

Variants for CFAP73 Gene

Sequence variations from dbSNP and Humsavar for CFAP73 Gene

SNP ID Clin Chr 12 pos Sequence Context AA Info Type
rs1048889 -- 113,159,061(-) CCGCC(C/T)GGAAC downstream-variant-500B, reference, missense, utr-variant-3-prime
rs11066500 -- 113,149,765(+) GCAGG(C/T)TTCCA upstream-variant-2KB, reference, missense
rs11066501 -- 113,151,080(+) aatgc(A/T)agttc intron-variant
rs11066502 -- 113,154,168(+) CAGCT(A/G)CTTTG intron-variant
rs111405240 -- 113,157,739(+) AGGGC(C/T)CACAT intron-variant, utr-variant-3-prime

Structural Variations from Database of Genomic Variants (DGV) for CFAP73 Gene

Variant ID Type Subtype PubMed ID
dgv2884n54 CNV loss 21841781
esv3630792 CNV gain 21293372
esv3892265 CNV gain 25118596
nsv519540 CNV gain+loss 19592680

Variation tolerance for CFAP73 Gene

Gene Damage Index Score: 3.65; 56.81% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CFAP73 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CFAP73

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CFAP73 Gene

Disorders for CFAP73 Gene

Relevant External Links for CFAP73

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CFAP73
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CFAP73

No disorders were found for CFAP73 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CFAP73 Gene

Publications for CFAP73 Gene

  1. The MIA complex is a conserved and novel dynein regulator essential for normal ciliary motility. (PMID: 23569216) Yamamoto R. … Sale W.S. (J. Cell Biol. 2013) 2 3 64
  2. The finished DNA sequence of human chromosome 12. (PMID: 16541075) Scherer S.E. … Gibbs R.A. (Nature 2006) 3 4 64

Products for CFAP73 Gene

Sources for CFAP73 Gene

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