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Aliases for CFAP70 Gene

Aliases for CFAP70 Gene

  • Cilia And Flagella Associated Protein 70 2 3 5
  • Tetratricopeptide Repeat Protein 18 3 4
  • Tetratricopeptide Repeat Domain 18 2 3
  • TPR Repeat Protein 18 3 4
  • TTC18 3 4
  • Tetratricopeptide Repeat-Containing Protein (LOC118491) 3

External Ids for CFAP70 Gene

Previous HGNC Symbols for CFAP70 Gene

  • TTC18

Summaries for CFAP70 Gene

GeneCards Summary for CFAP70 Gene

CFAP70 (Cilia And Flagella Associated Protein 70) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFAP70 Gene

Genomics for CFAP70 Gene

Regulatory Elements for CFAP70 Gene

Enhancers for CFAP70 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CFAP70 on UCSC Golden Path with GeneCards custom track

Genomic Location for CFAP70 Gene

Chromosome:
10
Start:
73,253,758 bp from pter
End:
73,361,064 bp from pter
Size:
107,307 bases
Orientation:
Minus strand

Genomic View for CFAP70 Gene

Genes around CFAP70 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CFAP70 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CFAP70 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFAP70 Gene

Proteins for CFAP70 Gene

  • Protein details for CFAP70 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T0N1-CFA70_HUMAN
    Recommended name:
    Cilia- and flagella-associated protein 70
    Protein Accession:
    Q5T0N1
    Secondary Accessions:
    • C9JIZ9
    • Q5T0M4
    • Q5T0M9
    • Q5T0N0
    • Q69YH9
    • Q8IYZ8
    • Q8N7D5
    • Q8NI30
    • Q8NI31

    Protein attributes for CFAP70 Gene

    Size:
    1121 amino acids
    Molecular mass:
    125721 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAM20909.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=AAM20910.1; Type=Frameshift; Positions=Several; Evidence={ECO:0000305}; Sequence=BAC05358.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=CAI15293.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15294.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15295.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305}; Sequence=CAI15296.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CFAP70 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CFAP70 Gene

Proteomics data for CFAP70 Gene at MOPED

Post-translational modifications for CFAP70 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CFAP70 Gene

No data available for DME Specific Peptides for CFAP70 Gene

Domains & Families for CFAP70 Gene

Gene Families for CFAP70 Gene

Protein Domains for CFAP70 Gene

Suggested Antigen Peptide Sequences for CFAP70 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T0N1

UniProtKB/Swiss-Prot:

CFA70_HUMAN :
  • Belongs to the CFAP70 family.
  • Contains 8 TPR repeats.
Family:
  • Belongs to the CFAP70 family.
Similarity:
  • Contains 8 TPR repeats.
genes like me logo Genes that share domains with CFAP70: view

Function for CFAP70 Gene

Gene Ontology (GO) - Molecular Function for CFAP70 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003674 molecular_function ND --
genes like me logo Genes that share ontologies with CFAP70: view
genes like me logo Genes that share phenotypes with CFAP70: view

Animal Model Products

miRNA for CFAP70 Gene

miRTarBase miRNAs that target CFAP70

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CFAP70 Gene

Localization for CFAP70 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFAP70 Gene

Cell projection, cilium.

No data available for Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CFAP70 Gene

Pathways & Interactions for CFAP70 Gene

SuperPathways for CFAP70 Gene

No Data Available

Interacting Proteins for CFAP70 Gene

Gene Ontology (GO) - Biological Process for CFAP70 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CFAP70 Gene

Drugs & Compounds for CFAP70 Gene

No Compound Related Data Available

Transcripts for CFAP70 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CFAP70 Gene

No ASD Table

Relevant External Links for CFAP70 Gene

GeneLoc Exon Structure for
CFAP70
ECgene alternative splicing isoforms for
CFAP70

Expression for CFAP70 Gene

mRNA expression in normal human tissues for CFAP70 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CFAP70 Gene

This gene is overexpressed in Plasma (49.2), Monocytes (10.5), and Heart (8.2).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CFAP70 Gene



genes like me logo Genes that share expression patterns with CFAP70: view

Protein tissue co-expression partners for CFAP70 Gene

- Elite partner

Primer Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CFAP70 Gene

Orthologs for CFAP70 Gene

This gene was present in the common ancestor of chordates.

Orthologs for CFAP70 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia TTC18 35
  • 88.54 (n)
  • 87.14 (a)
dog
(Canis familiaris)
Mammalia TTC18 35
  • 90.83 (n)
  • 88.98 (a)
TTC18 36
  • 86 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ttc18 35
  • 81.62 (n)
  • 81.92 (a)
Cfap70 16
Ttc18 36
  • 80 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia TTC18 35
  • 99.7 (n)
  • 99.29 (a)
TTC18 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ttc18 35
  • 80.91 (n)
  • 82.44 (a)
oppossum
(Monodelphis domestica)
Mammalia TTC18 36
  • 70 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 70 (a)
OneToMany
-- 36
  • 73 (a)
OneToMany
-- 36
  • 66 (a)
OneToMany
chicken
(Gallus gallus)
Aves TTC18 35
  • 64.93 (n)
  • 58.32 (a)
TTC18 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia TTC18 36
  • 63 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia Str.13839 35
ttc18 35
  • 61.3 (n)
  • 57.02 (a)
zebrafish
(Danio rerio)
Actinopterygii si:dkey-254e1.1 35
  • 56.1 (n)
  • 50.43 (a)
TTC18 36
  • 47 (a)
OneToOne
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.13169 35
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 42 (a)
OneToOne
Species with no ortholog for CFAP70:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFAP70 Gene

ENSEMBL:
Gene Tree for CFAP70 (if available)
TreeFam:
Gene Tree for CFAP70 (if available)

Paralogs for CFAP70 Gene

No data available for Paralogs for CFAP70 Gene

Variants for CFAP70 Gene

Sequence variations from dbSNP and Humsavar for CFAP70 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs12256262 - 73,278,241(+) GATCC(A/C)AAGTT intron-variant, reference, missense, utr-variant-3-prime
VAR_032878 -
rs1537273 -- 73,355,203(-) ctcgc(C/T)tgctg intron-variant
rs3812622 -- 73,348,388(+) GCTTT(G/T)CCATT intron-variant
rs3891988 -- 73,362,647(+) tgaat(G/T)tatta upstream-variant-2KB

Variation tolerance for CFAP70 Gene

Residual Variation Intolerance Score: 9.27% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 8.98; 87.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CFAP70 Gene

HapMap Linkage Disequilibrium report
CFAP70

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CFAP70 Gene

Disorders for CFAP70 Gene

Relevant External Links for CFAP70

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CFAP70

No disorders were found for CFAP70 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CFAP70 Gene

Publications for CFAP70 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 67
  2. Large-scale proteomics and phosphoproteomics of urinary exosomes. (PMID: 19056867) Gonzales P.A. … Knepper M.A. (J. Am. Soc. Nephrol. 2009) 3
  3. A scan of chromosome 10 identifies a novel locus showing strong association with late-onset Alzheimer disease. (PMID: 16385451) Grupe A. … Goate A. (Am. J. Hum. Genet. 2006) 3
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3

Products for CFAP70 Gene

Sources for CFAP70 Gene

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