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Aliases for CFAP61 Gene

Aliases for CFAP61 Gene

  • Cilia And Flagella Associated Protein 61 2 3
  • C20orf26 3 4
  • Chromosome 20 Open Reading Frame 26 2
  • Hypothetical Protein LOC26074 2
  • DJ1002M8.3 3
  • DJ1178H5.4 3
  • CaM-IP3 3

External Ids for CFAP61 Gene

Previous HGNC Symbols for CFAP61 Gene

  • C20orf26

Summaries for CFAP61 Gene

GeneCards Summary for CFAP61 Gene

CFAP61 (Cilia And Flagella Associated Protein 61) is a Protein Coding gene. GO annotations related to this gene include oxidoreductase activity.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFAP61 Gene

Genomics for CFAP61 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CFAP61 Gene

Chromosome:
20
Start:
20,052,514 bp from pter
End:
20,360,714 bp from pter
Size:
308,201 bases
Orientation:
Plus strand

Genomic View for CFAP61 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CFAP61 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFAP61 Gene

No data available for Regulatory Elements for CFAP61 Gene

Proteins for CFAP61 Gene

  • Protein details for CFAP61 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8NHU2-CFA61_HUMAN
    Recommended name:
    Cilia- and flagella-associated protein 61
    Protein Accession:
    Q8NHU2
    Secondary Accessions:
    • A6NHA1
    • Q5JXV4
    • Q5TE18
    • Q8N5R9
    • Q96M59
    • Q9BQL2
    • Q9H127
    • Q9H128
    • Q9NQH4
    • Q9UFV8
    • Q9Y4V7

    Protein attributes for CFAP61 Gene

    Size:
    1237 amino acids
    Molecular mass:
    141349 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=CAI42114.1; Type=Erroneous gene model prediction; Evidence={ECO:0000305};

    Alternative splice isoforms for CFAP61 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CFAP61 Gene

Proteomics data for CFAP61 Gene at MOPED

Post-translational modifications for CFAP61 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CFAP61 Gene

Domains & Families for CFAP61 Gene

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CFAP61: view

No data available for Gene Families and UniProtKB/Swiss-Prot for CFAP61 Gene

Function for CFAP61 Gene

Phenotypes for CFAP61 Gene

GenomeRNAi human phenotypes for CFAP61:
genes like me logo Genes that share phenotypes with CFAP61: view

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CFAP61 Gene

Localization for CFAP61 Gene

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from COMPARTMENTS and Gene Ontology (GO) - Cellular Components for CFAP61 Gene

Pathways & Interactions for CFAP61 Gene

SuperPathways for CFAP61 Gene

No Data Available

Interacting Proteins for CFAP61 Gene

Selected Interacting proteins: Q8NHU2-CFA61_HUMAN for CFAP61 Gene via MINT

Symbol External ID(s) Details
--

Gene Ontology (GO) - Biological Process for CFAP61 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CFAP61 Gene

Drugs & Compounds for CFAP61 Gene

No Compound Related Data Available

Transcripts for CFAP61 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CFAP61 Gene

ExUns: 1 ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16 ^ 17 ^ 18a · 18b ^ 19 ^ 20a · 20b ^ 21 ^ 22 ^ 23 ^ 24 ^
SP1: - - - - - - - -
SP2: -
SP3:
SP4: - -
SP5: -

ExUns: 25 ^ 26 ^ 27 ^ 28 ^ 29 ^ 30 ^ 31 ^ 32 ^ 33a · 33b
SP1:
SP2: -
SP3:
SP4:
SP5:

Relevant External Links for CFAP61 Gene

GeneLoc Exon Structure for
CFAP61
ECgene alternative splicing isoforms for
CFAP61

Expression for CFAP61 Gene

mRNA expression in normal human tissues for CFAP61 Gene

Protein differential expression in normal tissues from HIPED for CFAP61 Gene

This gene is overexpressed in Esophagus (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CFAP61 Gene



genes like me logo Genes that share expression patterns with CFAP61: view

Protein tissue co-expression partners for CFAP61 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CFAP61 Gene

Orthologs for CFAP61 Gene

This gene was present in the common ancestor of animals.

Orthologs for CFAP61 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia C13H20orf26 35
  • 82.39 (n)
  • 80.5 (a)
C20orf26 36
  • 80 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C24H20orf26 35
  • 87.25 (n)
  • 85.45 (a)
C20orf26 36
  • 85 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1311519 35
  • 80.67 (n)
  • 77.7 (a)
mouse
(Mus musculus)
Mammalia 4930529M08Rik 16
4930529M08Rik 36
  • 77 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia C20orf26 36
  • 69 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 75 (a)
OneToMany
-- 36
  • 60 (a)
OneToMany
-- 36
  • 62 (a)
OneToMany
-- 36
  • 63 (a)
OneToMany
-- 36
  • 48 (a)
OneToMany
-- 36
  • 67 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia C20orf26 36
  • 99 (a)
OneToOne
chicken
(Gallus gallus)
Aves C3H20ORF26 35
  • 66.93 (n)
  • 60.59 (a)
C20orf26 36
  • 55 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C20orf26 36
  • 62 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c20orf26 35
  • 63.72 (n)
  • 60.52 (a)
zebrafish
(Danio rerio)
Actinopterygii si:zfos-223e1.2 35
  • 57.13 (n)
  • 50 (a)
C20H20orf26 (2 of 2) 36
  • 48 (a)
OneToMany
C20orf26 (1 of 2) 36
  • 42 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG30268 36
  • 18 (a)
OneToMany
CG30275 36
  • 18 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 43 (a)
OneToOne
Species with no ortholog for CFAP61:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFAP61 Gene

ENSEMBL:
Gene Tree for CFAP61 (if available)
TreeFam:
Gene Tree for CFAP61 (if available)

Paralogs for CFAP61 Gene

No data available for Paralogs for CFAP61 Gene

Variants for CFAP61 Gene

Sequence variations from dbSNP and Humsavar for CFAP61 Gene

SNP ID Clin Chr 20 pos Sequence Context AA Info Type MAF
rs200180 -- 20,065,278(+) accta(C/G)taggc intron-variant
rs200181 -- 20,067,284(+) ACATT(G/T)AAAAA intron-variant
rs200182 -- 20,069,055(+) tctat(A/T)tatac intron-variant
rs200183 -- 20,069,753(+) ttctc(A/G)ttctt intron-variant
rs200184 -- 20,071,246(+) AATGA(C/T)GGCGG intron-variant

Variation tolerance for CFAP61 Gene

Residual Variation Intolerance Score: 80.89% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.72; 78.71% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CFAP61 Gene

HapMap Linkage Disequilibrium report
CFAP61

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CFAP61 Gene

Disorders for CFAP61 Gene

Relevant External Links for CFAP61

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CFAP61
genes like me logo Genes that share disorders with CFAP61: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CFAP61 Gene

Publications for CFAP61 Gene

  1. A conserved CaM- and radial spoke associated complex mediates regulation of flagellar dynein activity. (PMID: 17967944) Dymek E.E. … Smith E.F. (J. Cell Biol. 2007) 2 67
  2. The DNA sequence and comparative analysis of human chromosome 20. (PMID: 11780052) Deloukas P. … Rogers J. (Nature 2001) 2 67
  3. Diagnostic exome sequencing in persons with severe intellectual disability. (PMID: 23033978) de Ligt J. … Vissers L.E. (N. Engl. J. Med. 2012) 67
  4. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 67
  5. The SH3 domain of postsynaptic density 95 mediates inflammatory pain through phosphatidylinositol-3-kinase recruitment. (PMID: 20467438) Arbuckle M.I. … Grant S.G. (EMBO Rep. 2010) 67

Products for CFAP61 Gene

Sources for CFAP61 Gene

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