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Aliases for CFAP58 Gene

Aliases for CFAP58 Gene

  • Cilia And Flagella Associated Protein 58 2 3 5
  • Coiled-Coil Domain-Containing Protein 147 3 4
  • Coiled-Coil Domain Containing 147 2 3
  • C10orf80 3 4
  • CCDC147 3 4
  • Chromosome 10 Open Reading Frame 80 2
  • BA127L20.4 (Novel Protein) 3
  • BA127L20.5 (Novel Protein) 3
  • BA127L20.4 3
  • BA127L20.5 3
  • BA554P13.1 3

External Ids for CFAP58 Gene

Previous HGNC Symbols for CFAP58 Gene

  • C10orf80
  • CCDC147

Summaries for CFAP58 Gene

GeneCards Summary for CFAP58 Gene

CFAP58 (Cilia And Flagella Associated Protein 58) is a Protein Coding gene. An important paralog of this gene is CCDC146.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFAP58 Gene

Genomics for CFAP58 Gene

Genomic Location for CFAP58 Gene

Chromosome:
10
Start:
104,338,558 bp from pter
End:
104,455,090 bp from pter
Size:
116,533 bases
Orientation:
Plus strand

Genomic View for CFAP58 Gene

Genes around CFAP58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CFAP58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CFAP58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFAP58 Gene

No data available for Regulatory Elements for CFAP58 Gene

Proteins for CFAP58 Gene

  • Protein details for CFAP58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T655-CFA58_HUMAN
    Recommended name:
    Cilia- and flagella-associated protein 58
    Protein Accession:
    Q5T655
    Secondary Accessions:
    • D3DRA6
    • Q8NA27

    Protein attributes for CFAP58 Gene

    Size:
    872 amino acids
    Molecular mass:
    103417 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CFAP58 Gene

Proteomics data for CFAP58 Gene at MOPED

Post-translational modifications for CFAP58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CFAP58 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CFAP58 Gene

Domains & Families for CFAP58 Gene

Protein Domains for CFAP58 Gene

Suggested Antigen Peptide Sequences for CFAP58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T655

UniProtKB/Swiss-Prot:

CFA58_HUMAN :
  • Belongs to the CFAP58 family.
Family:
  • Belongs to the CFAP58 family.
genes like me logo Genes that share domains with CFAP58: view

No data available for Gene Families for CFAP58 Gene

Function for CFAP58 Gene

genes like me logo Genes that share phenotypes with CFAP58: view

Animal Model Products

miRNA for CFAP58 Gene

miRTarBase miRNAs that target CFAP58

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CFAP58 Gene

Localization for CFAP58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFAP58 Gene

Cell projection, cilium.

Gene Ontology (GO) - Cellular Components for CFAP58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with CFAP58: view

No data available for Subcellular locations from COMPARTMENTS for CFAP58 Gene

Pathways & Interactions for CFAP58 Gene

SuperPathways for CFAP58 Gene

No Data Available

Interacting Proteins for CFAP58 Gene

Gene Ontology (GO) - Biological Process for CFAP58 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CFAP58 Gene

Drugs & Compounds for CFAP58 Gene

No Compound Related Data Available

Transcripts for CFAP58 Gene

mRNA/cDNA for CFAP58 Gene

(4) REFSEQ mRNAs :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Alternative Splicing Database (ASD) splice patterns (SP) for CFAP58 Gene

No ASD Table

Relevant External Links for CFAP58 Gene

GeneLoc Exon Structure for
CFAP58
ECgene alternative splicing isoforms for
CFAP58

Expression for CFAP58 Gene

mRNA expression in normal human tissues for CFAP58 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CFAP58 Gene

This gene is overexpressed in Nasal epithelium (34.4), Lavage (17.2), and Platelet (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CFAP58 Gene



genes like me logo Genes that share expression patterns with CFAP58: view

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues , mRNA Expression by UniProt/SwissProt and Protein tissue co-expression partners for CFAP58 Gene

Orthologs for CFAP58 Gene

This gene was present in the common ancestor of animals.

Orthologs for CFAP58 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC147 35
  • 89.02 (n)
  • 91.21 (a)
CCDC147 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC147 35
  • 89.79 (n)
  • 90.4 (a)
CCDC147 36
  • 89 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc147 35
  • 83.96 (n)
  • 87.62 (a)
Cfap58 16
Ccdc147 36
  • 86 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCDC147 35
  • 99.46 (n)
  • 99.66 (a)
CCDC147 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc147 35
  • 84.36 (n)
  • 87.74 (a)
oppossum
(Monodelphis domestica)
Mammalia CCDC147 36
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 80 (a)
OneToMany
-- 36
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves CCDC147 35
  • 72.26 (n)
  • 68.79 (a)
CCDC147 36
  • 68 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC147 36
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc147 35
  • 72.31 (n)
  • 75.15 (a)
Str.17238 35
African clawed frog
(Xenopus laevis)
Amphibia Xl.32243 35
zebrafish
(Danio rerio)
Actinopterygii ccdc147 35
  • 65.65 (n)
  • 65.01 (a)
Dr.18541 35
ccdc147 36
  • 62 (a)
OneToOne
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003679 35
  • 47.14 (n)
  • 33.33 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG5882 35
  • 43.21 (n)
  • 27.15 (a)
CG5882 36
  • 23 (a)
ManyToMany
CG6059 36
  • 19 (a)
ManyToMany
Ory 36
  • 24 (a)
ManyToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4096 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9178 36
  • 63 (a)
OneToOne
Species with no ortholog for CFAP58:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFAP58 Gene

ENSEMBL:
Gene Tree for CFAP58 (if available)
TreeFam:
Gene Tree for CFAP58 (if available)

Paralogs for CFAP58 Gene

Paralogs for CFAP58 Gene

genes like me logo Genes that share paralogs with CFAP58: view

Variants for CFAP58 Gene

Sequence variations from dbSNP and Humsavar for CFAP58 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs11192036 - 104,392,353(+) TGAGA(A/T)CAGAC reference, missense
rs7087328 - 104,450,106(+) GTACA(A/G/T)AGCAA reference, missense
rs1023122 -- 104,403,667(+) ATTAA(A/C)GATAG intron-variant
rs914067 -- 104,377,428(+) GGTTA(C/T)GGCAG intron-variant
rs914068 -- 104,377,468(+) TTAAA(G/T)GTAGG intron-variant

Variation tolerance for CFAP58 Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.89; 89.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CFAP58 Gene

HapMap Linkage Disequilibrium report
CFAP58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CFAP58 Gene

Disorders for CFAP58 Gene

Relevant External Links for CFAP58

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CFAP58

No disorders were found for CFAP58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CFAP58 Gene

Publications for CFAP58 Gene

  1. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 67
  2. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3
  3. A proteome-scale map of the human interactome network. (PMID: 25416956) Rolland T. … Vidal M. (Cell 2014) 3
  4. Shotgun proteomics reveals specific modulated protein patterns in tears of patients with primary open angle glaucoma naA^ve to therapy. (PMID: 23580065) Pieragostino D. … Del Boccio P. (Mol Biosyst 2013) 3
  5. Interactions of pathological hallmark proteins: tubulin polymerization promoting protein/p25, beta-amyloid, and alpha-synuclein. (PMID: 21832049) OlA!h J. … OvA!di J. (J. Biol. Chem. 2011) 3

Products for CFAP58 Gene

Sources for CFAP58 Gene

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