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Aliases for CFAP58 Gene

Aliases for CFAP58 Gene

  • Cilia And Flagella Associated Protein 58 2 3 5
  • Coiled-Coil Domain-Containing Protein 147 3 4
  • Coiled-Coil Domain Containing 147 2 3
  • C10orf80 3 4
  • CCDC147 3 4
  • Cilia- And Flagella-Associated Protein 58 3
  • Chromosome 10 Open Reading Frame 80 2
  • BA127L20.4 (Novel Protein) 3
  • BA127L20.5 (Novel Protein) 3
  • BA127L20.4 3
  • BA127L20.5 3
  • BA554P13.1 3

External Ids for CFAP58 Gene

Previous HGNC Symbols for CFAP58 Gene

  • C10orf80
  • CCDC147

Summaries for CFAP58 Gene

GeneCards Summary for CFAP58 Gene

CFAP58 (Cilia And Flagella Associated Protein 58) is a Protein Coding gene. An important paralog of this gene is CCDC146.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFAP58 Gene

Genomics for CFAP58 Gene

Regulatory Elements for CFAP58 Gene

Enhancers for CFAP58 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH10F104348 1.4 FANTOM5 ENCODE 25.1 +12.9 12929 5.5 HDGF ATF1 PKNOX1 ARID4B SIN3A FEZF1 GLIS2 ZNF143 ZNF207 ZNF548 ITPRIP CFAP58 PDCD11 ENSG00000260461 SFR1 GSTO1 SLK CFAP58-AS1
GH10F104316 1.8 FANTOM5 Ensembl ENCODE 18.4 -9.8 -9787 24.8 HDGF PKNOX1 ARNT WRNIP1 ARID4B SIN3A FEZF1 ZNF2 YY1 ZNF143 PDCD11 ITPRIP GSTO2 ENSG00000260461 CFAP58 SFR1 CFAP58-AS1 STN1 GSTO1 SLK
GH10F104249 1.4 Ensembl ENCODE 10.8 -84.8 -84841 7.6 MLX ARID4B SIN3A FEZF1 DMAP1 ZNF2 YY1 ZNF548 SP3 SP5 GSTO2 GSTO1 PDCD11 CFAP58 CFAP58-AS1 ENSG00000260461 GC10M104249 MIR4482
GH10F104302 1.1 Ensembl ENCODE 12.6 -32.4 -32415 6.4 HDAC1 ATF1 FEZF1 RAD21 ZBTB40 YY1 SCRT2 ZNF143 ZNF654 ZBTB2 GSTO2 CFAP58 CFAP58-AS1 ITPRIP GSTO1 GC10P104302 ENSG00000270075
GH10F104296 1.1 Ensembl ENCODE 12.2 -38.8 -38809 6.0 CTCF JUN SIN3A MAX BRCA1 RAD21 ZNF366 POLR2A SMC3 FOS GSTO2 CFAP58 CFAP58-AS1 ITPRIP GSTO1 GC10P104302
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CFAP58 on UCSC Golden Path with GeneCards custom track

Promoters for CFAP58 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters
ENSR00000361266 -258 3801 ARNT WRNIP1 ARID4B SIN3A FEZF1 YY1 FOS ZNF263 SP3 REST

Genomic Location for CFAP58 Gene

Chromosome:
10
Start:
104,338,558 bp from pter
End:
104,455,090 bp from pter
Size:
116,533 bases
Orientation:
Plus strand

Genomic View for CFAP58 Gene

Genes around CFAP58 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CFAP58 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CFAP58 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFAP58 Gene

Proteins for CFAP58 Gene

  • Protein details for CFAP58 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5T655-CFA58_HUMAN
    Recommended name:
    Cilia- and flagella-associated protein 58
    Protein Accession:
    Q5T655
    Secondary Accessions:
    • D3DRA6
    • Q8NA27

    Protein attributes for CFAP58 Gene

    Size:
    872 amino acids
    Molecular mass:
    103417 Da
    Quaternary structure:
    No Data Available

neXtProt entry for CFAP58 Gene

Post-translational modifications for CFAP58 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CFAP58 Gene

No data available for DME Specific Peptides for CFAP58 Gene

Domains & Families for CFAP58 Gene

Protein Domains for CFAP58 Gene

Suggested Antigen Peptide Sequences for CFAP58 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q5T655

UniProtKB/Swiss-Prot:

CFA58_HUMAN :
  • Belongs to the CFAP58 family.
Family:
  • Belongs to the CFAP58 family.
genes like me logo Genes that share domains with CFAP58: view

No data available for Gene Families for CFAP58 Gene

Function for CFAP58 Gene

Gene Ontology (GO) - Molecular Function for CFAP58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 25416956
genes like me logo Genes that share ontologies with CFAP58: view
genes like me logo Genes that share phenotypes with CFAP58: view

Animal Model Products

miRNA for CFAP58 Gene

miRTarBase miRNAs that target CFAP58

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CFAP58 Gene

Localization for CFAP58 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFAP58 Gene

Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CFAP58 gene
Compartment Confidence
extracellular 5
nucleus 4
cytosol 2
golgi apparatus 2

Gene Ontology (GO) - Cellular Components for CFAP58 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IDA 23580065
GO:0005929 cilium IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with CFAP58: view

Pathways & Interactions for CFAP58 Gene

SuperPathways for CFAP58 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CFAP58 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CFAP58 Gene

Transcripts for CFAP58 Gene

mRNA/cDNA for CFAP58 Gene

(6) REFSEQ mRNAs :
(12) Selected AceView cDNA sequences:
(2) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CFAP58 Gene

No ASD Table

Relevant External Links for CFAP58 Gene

GeneLoc Exon Structure for
CFAP58
ECgene alternative splicing isoforms for
CFAP58

Expression for CFAP58 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CFAP58 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CFAP58 Gene

This gene is overexpressed in Nasal epithelium (34.4), Lavage (17.2), and Platelet (7.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CFAP58 Gene



NURSA nuclear receptor signaling pathways regulating expression of CFAP58 Gene:

CFAP58
genes like me logo Genes that share expression patterns with CFAP58: view

Primer Products

No data available for mRNA differential expression in normal tissues , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CFAP58 Gene

Orthologs for CFAP58 Gene

This gene was present in the common ancestor of animals.

Orthologs for CFAP58 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC147 34 35
  • 99.46 (n)
dog
(Canis familiaris)
Mammalia CCDC147 34 35
  • 89.79 (n)
cow
(Bos Taurus)
Mammalia CCDC147 34 35
  • 89.02 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc147 34
  • 84.36 (n)
mouse
(Mus musculus)
Mammalia Ccdc147 34 35
  • 83.96 (n)
Cfap58 16
oppossum
(Monodelphis domestica)
Mammalia CCDC147 35
  • 83 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 80 (a)
OneToMany
-- 35
  • 79 (a)
OneToMany
chicken
(Gallus gallus)
Aves CCDC147 34 35
  • 72.26 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC147 35
  • 74 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc147 34
  • 72.31 (n)
Str.17238 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.32243 34
zebrafish
(Danio rerio)
Actinopterygii ccdc147 34 35
  • 65.65 (n)
Dr.18541 34
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP003679 34
  • 47.14 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG5882 34 35
  • 43.21 (n)
Ory 35
  • 24 (a)
ManyToMany
CG6059 35
  • 19 (a)
ManyToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.9178 35
  • 63 (a)
OneToOne
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.4096 34
Species where no ortholog for CFAP58 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFAP58 Gene

ENSEMBL:
Gene Tree for CFAP58 (if available)
TreeFam:
Gene Tree for CFAP58 (if available)

Paralogs for CFAP58 Gene

Paralogs for CFAP58 Gene

genes like me logo Genes that share paralogs with CFAP58: view

Variants for CFAP58 Gene

Sequence variations from dbSNP and Humsavar for CFAP58 Gene

SNP ID Clin Chr 10 pos Sequence Context AA Info Type
rs1023122 -- 104,403,667(+) ATTAA(A/C)GATAG intron-variant
rs10491047 -- 104,384,699(+) CAAAG(A/G)TTGTA intron-variant
rs10509770 -- 104,393,141(+) TTTTG(A/C)GAGTT intron-variant
rs10509771 -- 104,395,792(+) CTACG(C/T)GGGTA intron-variant
rs10509772 -- 104,399,547(+) ACACG(A/G)GTATT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CFAP58 Gene

Variant ID Type Subtype PubMed ID
nsv25421 CNV deletion 16902084
nsv1144515 CNV deletion 24896259
esv3546787 CNV deletion 23714750
esv2740373 CNV deletion 23290073
esv2136408 CNV deletion 18987734
esv2112142 CNV deletion 18987734

Variation tolerance for CFAP58 Gene

Residual Variation Intolerance Score: 90.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 9.89; 89.73% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CFAP58 Gene

Human Gene Mutation Database (HGMD)
CFAP58
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CFAP58

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CFAP58 Gene

Disorders for CFAP58 Gene

Relevant External Links for CFAP58

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CFAP58

No disorders were found for CFAP58 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CFAP58 Gene

Publications for CFAP58 Gene

  1. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  2. The DNA sequence and comparative analysis of human chromosome 10. (PMID: 15164054) Deloukas P. … Rogers J. (Nature 2004) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Focused Analysis of Exome Sequencing Data for Rare Germline Mutations in Familial and Sporadic Lung Cancer. (PMID: 26762739) Liu Y. … Spitz M.R. (J Thorac Oncol 2016) 3 64
  5. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64

Products for CFAP58 Gene

Sources for CFAP58 Gene

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