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Aliases for CFAP52 Gene

Aliases for CFAP52 Gene

  • Cilia And Flagella Associated Protein 52 2 3
  • WDRPUH 3 4 6
  • WDR16 3 4 6
  • WD40-Repeat Protein Up-Regulated In HCC 3 4
  • WD40-Repeat Protein Upregulated In HCC 2 3
  • WD Repeat-Containing Protein 16 3 4
  • WD Repeat Domain 16 2 3
  • Cilia- And Flagella-Associated Protein 52 3

External Ids for CFAP52 Gene

Previous HGNC Symbols for CFAP52 Gene

  • WDR16

Summaries for CFAP52 Gene

Entrez Gene Summary for CFAP52 Gene

  • WD repeat-containing proteins, such as WDR16, play crucial roles in a wide range of physiologic functions, including signal transduction, RNA processing, remodeling the cytoskeleton, regulation of vesicular traffic, and cell division (Silva et al., 2005 [PubMed 15967112]).[supplied by OMIM, Mar 2008]

GeneCards Summary for CFAP52 Gene

CFAP52 (Cilia And Flagella Associated Protein 52) is a Protein Coding gene. An important paralog of this gene is WDR90.

UniProtKB/Swiss-Prot for CFAP52 Gene

  • May play a role in cell growth and/or survival.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFAP52 Gene

Genomics for CFAP52 Gene

Genomic Location for CFAP52 Gene

Start:
9,576,627 bp from pter
End:
9,643,459 bp from pter
Size:
66,833 bases
Orientation:
Plus strand

Genomic View for CFAP52 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CFAP52 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFAP52 Gene

No data available for Regulatory Elements for CFAP52 Gene

Proteins for CFAP52 Gene

  • Protein details for CFAP52 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q8N1V2-CFA52_HUMAN
    Recommended name:
    Cilia- and flagella-associated protein 52
    Protein Accession:
    Q8N1V2
    Secondary Accessions:
    • B2RDU7
    • Q5DX23
    • Q8TC73
    • Q8TCI3

    Protein attributes for CFAP52 Gene

    Size:
    620 amino acids
    Molecular mass:
    68298 Da
    Quaternary structure:
    No Data Available
    Miscellaneous:
    • May be a good candidate as a diagnostic marker for HCC as well as a potential molecular target for development of novel therapeutic drugs
    SequenceCaution:
    • Sequence=BAB85083.1; Type=Frameshift; Positions=183; Evidence={ECO:0000305};

    Alternative splice isoforms for CFAP52 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CFAP52 Gene

Proteomics data for CFAP52 Gene at MOPED

Post-translational modifications for CFAP52 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

No data available for DME Specific Peptides for CFAP52 Gene

Domains for CFAP52 Gene

Gene Families for CFAP52 Gene

HGNC:
  • WDR :WD repeat domain containing

Graphical View of Domain Structure for InterPro Entry

Q8N1V2

UniProtKB/Swiss-Prot:

CFA52_HUMAN :
  • Q8N1V2
Family:
  • Belongs to the CFAP52 family.
Similarity:
  • Contains 11 WD repeats.
genes like me logo Genes that share domains with CFAP52: view

No data available for Suggested Antigen Peptide Sequences for CFAP52 Gene

Function for CFAP52 Gene

Molecular function for CFAP52 Gene

UniProtKB/Swiss-Prot Function: May play a role in cell growth and/or survival.

Gene Ontology (GO) - Molecular Function for CFAP52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding IPI 15967112
genes like me logo Genes that share ontologies with CFAP52: view

Phenotypes for CFAP52 Gene

genes like me logo Genes that share phenotypes with CFAP52: view

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CFAP52 Gene

Localization for CFAP52 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFAP52 Gene

Cytoplasm. Cell projection, cilium, flagellum.

Gene Ontology (GO) - Cellular Components for CFAP52 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005737 cytoplasm IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with CFAP52: view

No data available for Subcellular locations from COMPARTMENTS for CFAP52 Gene

Pathways for CFAP52 Gene

SuperPathways for CFAP52 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CFAP52 Gene

None

No data available for Pathways by source for CFAP52 Gene

Transcripts for CFAP52 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CFAP52

Primer Products

  • OriGene qSTAR qPCR primer pairs in human,mouse,rat for CFAP52
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CFAP52 Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15a · 15b
SP1:
SP2: -
SP3: - -

Relevant External Links for CFAP52 Gene

GeneLoc Exon Structure for
CFAP52
ECgene alternative splicing isoforms for
CFAP52

Expression for CFAP52 Gene

mRNA expression in normal human tissues for CFAP52 Gene

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CFAP52 Gene

mRNA Expression by UniProt/SwissProt for CFAP52 Gene

Q8N1V2-CFA52_HUMAN
Tissue specificity: Highly expressed in testis. Up-regulated in hepatocellular carcinoma (HCC).
genes like me logo Genes that share expressions with CFAP52: view

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CFAP52 Gene

Orthologs for CFAP52 Gene

This gene was present in the common ancestor of animals.

Orthologs for CFAP52 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia WDR16 35
  • 96.81 (n)
  • 97.08 (a)
WDR16 36
  • 95 (a)
OneToOne
cow
(Bos Taurus)
Mammalia WDR16 35
  • 87.37 (n)
  • 91.29 (a)
WDR16 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia WDR16 35
  • 88.33 (n)
  • 92.74 (a)
WDR16 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Wdr16 35
  • 86.18 (n)
  • 90.81 (a)
Wdr16 16
Wdr16 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia WDR16 36
  • 82 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia WDR16 36
  • 77 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Wdr16 35
  • 85.91 (n)
  • 90.65 (a)
chicken
(Gallus gallus)
Aves WDR16 35
  • 71.96 (n)
  • 71.19 (a)
WDR16 36
  • 70 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia WDR16 36
  • 72 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia wdr16 35
  • 68.73 (n)
  • 68.89 (a)
zebrafish
(Danio rerio)
Actinopterygii wdr16 35
  • 66.78 (n)
  • 64.16 (a)
wdr16 36
  • 64 (a)
OneToOne
wufj15f10 35
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP005915 35
  • 50.14 (n)
  • 43.25 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG10064 35
  • 50.11 (n)
  • 38.83 (a)
CG10064 36
  • 30 (a)
OneToMany
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.5015 35
sea squirt
(Ciona savignyi)
Ascidiacea CSA.7321 36
  • 64 (a)
OneToOne
Species with no ortholog for CFAP52:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFAP52 Gene

ENSEMBL:
Gene Tree for CFAP52 (if available)
TreeFam:
Gene Tree for CFAP52 (if available)

Paralogs for CFAP52 Gene

Paralogs for CFAP52 Gene

genes like me logo Genes that share paralogs with CFAP52: view

Variants for CFAP52 Gene

Sequence variations from dbSNP and Humsavar for CFAP52 Gene

SNP ID Clin Chr 17 pos Sequence Context AA Info Type MAF
rs274899 -- 9,643,234(-) GACTG(C/T)GTGCA utr-variant-3-prime
rs364423 -- 9,626,786(+) AAGTA(C/G)TCCAT intron-variant
rs368787 -- 9,622,927(-) gtaca(C/T)attga intron-variant
rs389995 -- 9,636,253(-) TCTTT(C/T)TCTTT intron-variant
rs418706 -- 9,635,332(-) AAGAG(A/C)TTTTT intron-variant

Relevant External Links for CFAP52 Gene

HapMap Linkage Disequilibrium report
CFAP52

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CFAP52 Gene

Disorders for CFAP52 Gene

No disorders were found for CFAP52 Gene.

No data available for UniProtKB/Swiss-Prot for CFAP52 Gene

Publications for CFAP52 Gene

  1. WDRPUH, a novel WD-repeat-containing protein, is highly expressed in human hepatocellular carcinoma and involved in cell proliferation. (PMID: 15967112) Silva F.P. … Furukawa Y. (Neoplasia 2005) 2 3 4
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  4. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg R.L. … Marra M.A. (Proc. Natl. Acad. Sci. U.S.A. 2002) 3
  5. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PMID: 16344560) Kimura K. … Sugano S. (Genome Res. 2006) 3

Products for CFAP52 Gene

  • antibodies-online proteins for CFAP52
  • antibodies-online antibodies for CFAP52
  • antibodies-online kits for CFAP52

Sources for CFAP52 Gene

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