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Aliases for CFAP45 Gene

Aliases for CFAP45 Gene

  • Cilia And Flagella Associated Protein 45 2 3 5
  • Nasopharyngeal Epithelium-Specific Protein 1 3 4
  • Coiled-Coil Domain Containing 19 2 3
  • CCDC19 3 4
  • NESG1 3 4
  • Coiled-Coil Domain-Containing Protein 19, Mitochondrial 3
  • Nasopharyngeal Epithelium Specific Protein 1 (NESG1) 3
  • Cilia- And Flagella-Associated Protein 45 3
  • Coiled-Coil Domain-Containing Protein 19 4
  • Protein CFAP45, Mitochondrial 3

External Ids for CFAP45 Gene

Previous HGNC Symbols for CFAP45 Gene

  • CCDC19

Summaries for CFAP45 Gene

GeneCards Summary for CFAP45 Gene

CFAP45 (Cilia And Flagella Associated Protein 45) is a Protein Coding gene. Diseases associated with CFAP45 include Pharynx Cancer.

No data available for Entrez Gene Summary , CIViC summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFAP45 Gene

Genomics for CFAP45 Gene

Regulatory Elements for CFAP45 Gene

Enhancers for CFAP45 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01G159936 2 FANTOM5 Ensembl ENCODE dbSUPER 4.4 -41.3 -41295 10.5 HDGF PKNOX1 CREB3L1 SIN3A FEZF1 ZNF2 ZBTB7B YY1 ZNF143 FOS ATP1A4 SNHG28 ENSG00000272668 KCNJ10 IGSF9 NHLH1 LINC01133 VSIG8 CFAP45 VANGL2
GH01G160187 1.5 Ensembl ENCODE dbSUPER 5.3 -290.6 -290615 6.7 HDGF ARNT SIN3A ARID4B DMAP1 ZNF2 ZNF143 ZNF548 DEK SP5 NCSTN ENSG00000228606 CASQ1 SNHG28 RPSAP18 SLAMF8 ACKR1 CADM3-AS1 ATP1A4 CFAP45
GH01G159899 1.4 Ensembl ENCODE dbSUPER 0.7 -0.7 -727 2.5 HDAC1 BMI1 RAD21 TCF12 SCRT2 FOS EGR2 ZNF592 ZNF217 ZNF579 ENSG00000272668 SNHG28 CFAP45 GC01P159904 PIR60584
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CFAP45 on UCSC Golden Path with GeneCards custom track

Genomic Location for CFAP45 Gene

Chromosome:
1
Start:
159,872,364 bp from pter
End:
159,900,163 bp from pter
Size:
27,800 bases
Orientation:
Minus strand

Genomic View for CFAP45 Gene

Genes around CFAP45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CFAP45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CFAP45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFAP45 Gene

Proteins for CFAP45 Gene

  • Protein details for CFAP45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q9UL16-CFA45_HUMAN
    Recommended name:
    Cilia- and flagella-associated protein 45
    Protein Accession:
    Q9UL16
    Secondary Accessions:
    • C9JH28
    • Q05BA3
    • Q5VU18

    Protein attributes for CFAP45 Gene

    Size:
    551 amino acids
    Molecular mass:
    65730 Da
    Quaternary structure:
    No Data Available
    SequenceCaution:
    • Sequence=AAD55817.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD55817.1; Type=Frameshift; Positions=441; Evidence={ECO:0000305};

    Alternative splice isoforms for CFAP45 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CFAP45 Gene

Post-translational modifications for CFAP45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CFAP45 Gene

No data available for DME Specific Peptides for CFAP45 Gene

Domains & Families for CFAP45 Gene

Protein Domains for CFAP45 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CFAP45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q9UL16

UniProtKB/Swiss-Prot:

CFA45_HUMAN :
  • Belongs to the CFAP45 family.
Family:
  • Belongs to the CFAP45 family.
genes like me logo Genes that share domains with CFAP45: view

No data available for Gene Families for CFAP45 Gene

Function for CFAP45 Gene

Phenotypes for CFAP45 Gene

genes like me logo Genes that share phenotypes with CFAP45: view

Animal Model Products

miRNA for CFAP45 Gene

miRTarBase miRNAs that target CFAP45

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CFAP45 Gene

Localization for CFAP45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFAP45 Gene

Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CFAP45 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 1

Gene Ontology (GO) - Cellular Components for CFAP45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10524255
GO:0005654 nucleoplasm IDA --
GO:0005929 cilium IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with CFAP45: view

Pathways & Interactions for CFAP45 Gene

SuperPathways for CFAP45 Gene

No Data Available

Interacting Proteins for CFAP45 Gene

Gene Ontology (GO) - Biological Process for CFAP45 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CFAP45 Gene

Transcripts for CFAP45 Gene

Alternative Splicing Database (ASD) splice patterns (SP) for CFAP45 Gene

No ASD Table

Relevant External Links for CFAP45 Gene

GeneLoc Exon Structure for
CFAP45
ECgene alternative splicing isoforms for
CFAP45

Expression for CFAP45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CFAP45 Gene

Protein differential expression in normal tissues from HIPED for CFAP45 Gene

This gene is overexpressed in Plasma (48.9) and Liver, secretome (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CFAP45 Gene



Protein tissue co-expression partners for CFAP45 Gene

NURSA nuclear receptor signaling pathways regulating expression of CFAP45 Gene:

CFAP45

mRNA Expression by UniProt/SwissProt for CFAP45 Gene:

Q9UL16-CFA45_HUMAN
Tissue specificity: Expressed in nasopharyngeal epithelium and trachea but not in esophagus, stomach, large intestine, liver, cerebrum, heart, bladder, kidney, thymus, or lung.

Evidence on tissue expression from TISSUES for CFAP45 Gene

  • Blood(2)
genes like me logo Genes that share expression patterns with CFAP45: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues and Phenotype-based relationships between genes and organs from Gene ORGANizer for CFAP45 Gene

Orthologs for CFAP45 Gene

This gene was present in the common ancestor of animals.

Orthologs for CFAP45 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CCDC19 34 35
  • 90.98 (n)
cow
(Bos Taurus)
Mammalia CCDC19 34 35
  • 89.44 (n)
rat
(Rattus norvegicus)
Mammalia Ccdc19 34
  • 85.77 (n)
mouse
(Mus musculus)
Mammalia Ccdc19 34 35
  • 84.75 (n)
Cfap45 16
dog
(Canis familiaris)
Mammalia CCDC19 34 35
  • 84.46 (n)
oppossum
(Monodelphis domestica)
Mammalia CCDC19 35
  • 65 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 52 (a)
OneToMany
-- 35
  • 47 (a)
OneToMany
chicken
(Gallus gallus)
Aves CCDC19 34 35
  • 65.86 (n)
lizard
(Anolis carolinensis)
Reptilia CCDC19 35
  • 57 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc19 34
  • 64.5 (n)
MGC76242 34
zebrafish
(Danio rerio)
Actinopterygii ccdc19 34 35
  • 57.02 (n)
wufc64b08 34
fruit fly
(Drosophila melanogaster)
Insecta CG11449 34 35
  • 45.46 (n)
CG5062 35
  • 17 (a)
OneToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001112 34
  • 43.09 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
OneToOne
Species where no ortholog for CFAP45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFAP45 Gene

ENSEMBL:
Gene Tree for CFAP45 (if available)
TreeFam:
Gene Tree for CFAP45 (if available)

Paralogs for CFAP45 Gene

No data available for Paralogs for CFAP45 Gene

Variants for CFAP45 Gene

Sequence variations from dbSNP and Humsavar for CFAP45 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs1000004436 -- 159,896,640(+) GCCTA(A/C)GGAGA intron-variant
rs1000107619 -- 159,874,515(+) TAGCA(-/G)GGGGG intron-variant
rs1000324876 -- 159,894,041(+) GATTC(A/G)ATCAT intron-variant
rs1000344421 -- 159,878,176(+) TCAAG(A/T)TGCAA intron-variant
rs1000607023 -- 159,895,161(+) CAGTC(A/C)CAAGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CFAP45 Gene

Variant ID Type Subtype PubMed ID
esv3578218 CNV loss 25503493
nsv1005195 CNV gain 25217958
nsv464150 CNV gain 19166990
nsv548052 CNV gain 21841781

Variation tolerance for CFAP45 Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.53; 82.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CFAP45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CFAP45

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CFAP45 Gene

Disorders for CFAP45 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CFAP45 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
pharynx cancer
  • pharyngeal cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CFAP45

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CFAP45
genes like me logo Genes that share disorders with CFAP45: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CFAP45 Gene

Publications for CFAP45 Gene

  1. Molecular cloning of a novel tissue-specific gene from human nasopharyngeal epithelium. (PMID: 10524255) Li Z. … Cao Y. (Gene 1999) 2 3 4 64
  2. Decreased expression of updated NESG1 in nasopharyngeal carcinoma: its potential role and preliminarily functional mechanism. (PMID: 20715168) Liu Z. … Fang W. (Int. J. Cancer 2011) 2 3 64
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  4. Candidate tumour suppressor CCDC19 regulates miR-184 direct targeting of C-Myc thereby suppressing cell growth in non-small cell lung cancers. (PMID: 24976536) Liu Z. … Fang W. (J. Cell. Mol. Med. 2014) 3 64
  5. Proteomic features of potential tumor suppressor NESG1 in nasopharyngeal carcinoma. (PMID: 22997098) Liu Z. … Fang W. (Proteomics 2012) 3 64

Products for CFAP45 Gene

Sources for CFAP45 Gene

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