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Aliases for CFAP45 Gene

Aliases for CFAP45 Gene

  • Cilia And Flagella Associated Protein 45 2 3
  • CCDC19 3 4 6
  • NESG1 3 4 6
  • Nasopharyngeal Epithelium-Specific Protein 1 3 4
  • Coiled-Coil Domain Containing 19 2 3
  • Coiled-Coil Domain-Containing Protein 19, Mitochondrial 3
  • Nasopharyngeal Epithelium Specific Protein 1 (NESG1) 3
  • Cilia- And Flagella-Associated Protein 45 3
  • Coiled-Coil Domain-Containing Protein 19 4
  • Protein CFAP45, Mitochondrial 3

External Ids for CFAP45 Gene

Previous HGNC Symbols for CFAP45 Gene

  • CCDC19

Summaries for CFAP45 Gene

GeneCards Summary for CFAP45 Gene

CFAP45 (Cilia And Flagella Associated Protein 45) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFAP45 Gene

Genomics for CFAP45 Gene

Genomic Location for CFAP45 Gene

159,872,364 bp from pter
159,900,163 bp from pter
27,800 bases
Minus strand

Genomic View for CFAP45 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CFAP45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFAP45 Gene

No data available for Regulatory Elements for CFAP45 Gene

Proteins for CFAP45 Gene

  • Protein details for CFAP45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cilia- and flagella-associated protein 45
    Protein Accession:
    Secondary Accessions:
    • C9JH28
    • Q05BA3
    • Q5VU18

    Protein attributes for CFAP45 Gene

    551 amino acids
    Molecular mass:
    65730 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD55817.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD55817.1; Type=Frameshift; Positions=441; Evidence={ECO:0000305};

    Alternative splice isoforms for CFAP45 Gene


neXtProt entry for CFAP45 Gene

Proteomics data for CFAP45 Gene at MOPED

Post-translational modifications for CFAP45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CFAP45 Gene

No data available for DME Specific Peptides for CFAP45 Gene

Domains for CFAP45 Gene

Protein Domains for CFAP45 Gene


Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CFAP45 family.
  • Belongs to the CFAP45 family.
genes like me logo Genes that share domains with CFAP45: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CFAP45 Gene

Function for CFAP45 Gene

miRNA for CFAP45 Gene

miRTarBase miRNAs that target CFAP45

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CFAP45

In Situ Assay Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Phenotypes , Animal Models , Transcription Factor Targets and HOMER Transcription for CFAP45 Gene

Localization for CFAP45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFAP45 Gene

Cell projection, cilium.

Gene Ontology (GO) - Cellular Components for CFAP45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10524255
GO:0005654 nucleoplasm IDA --
GO:0005739 mitochondrion --
GO:0005929 cilium IEA --
genes like me logo Genes that share ontologies with CFAP45: view

No data available for Subcellular locations from COMPARTMENTS for CFAP45 Gene

Pathways for CFAP45 Gene

SuperPathways for CFAP45 Gene

No Data Available

Interacting Proteins for CFAP45 Gene

STRING Interaction Network Preview (showing 2 interactants - click image to see details)
Selected Interacting proteins: ENSP00000357079 Q9UL16-CFA45_HUMAN for CFAP45 Gene via STRING I2D

Gene Ontology (GO) - Biological Process for CFAP45 Gene


No data available for Pathways by source for CFAP45 Gene

Transcripts for CFAP45 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CFAP45

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CFAP45 Gene

No ASD Table

Relevant External Links for CFAP45 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CFAP45 Gene

mRNA expression in normal human tissues for CFAP45 Gene

Protein differential expression in normal tissues for CFAP45 Gene

This gene is overexpressed in Plasma (48.9) and Liver, secretome (15.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CFAP45 Gene

mRNA Expression by UniProt/SwissProt for CFAP45 Gene

Tissue specificity: Expressed in nasopharyngeal epithelium and trachea but not in esophagus, stomach, large intestine, liver, cerebrum, heart, bladder, kidney, thymus, or lung.
genes like me logo Genes that share expressions with CFAP45: view

Expression partners for CFAP45 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CFAP45 Gene

Orthologs for CFAP45 Gene

This gene was present in the common ancestor of animals.

Orthologs for CFAP45 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CCDC19 35
  • 89.44 (n)
  • 90.71 (a)
CCDC19 36
  • 91 (a)
(Canis familiaris)
Mammalia CCDC19 35
  • 84.46 (n)
  • 84.22 (a)
CCDC19 36
  • 84 (a)
(Mus musculus)
Mammalia Ccdc19 35
  • 84.75 (n)
  • 82.94 (a)
Ccdc19 16
Ccdc19 36
  • 83 (a)
(Pan troglodytes)
Mammalia CCDC19 35
  • 90.98 (n)
  • 88.53 (a)
CCDC19 36
  • 100 (a)
(Rattus norvegicus)
Mammalia Ccdc19 35
  • 85.77 (n)
  • 87.12 (a)
(Monodelphis domestica)
Mammalia CCDC19 36
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 52 (a)
-- 36
  • 47 (a)
(Gallus gallus)
Aves CCDC19 35
  • 65.86 (n)
  • 57.27 (a)
CCDC19 36
  • 57 (a)
(Anolis carolinensis)
Reptilia CCDC19 36
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc19 35
  • 64.5 (n)
  • 60.18 (a)
MGC76242 35
(Danio rerio)
Actinopterygii ccdc19 35
  • 57.02 (n)
  • 49.13 (a)
wufc64b08 35
ccdc19 36
  • 48 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001112 35
  • 43.09 (n)
  • 29.28 (a)
fruit fly
(Drosophila melanogaster)
Insecta CG11449 35
  • 45.46 (n)
  • 28.24 (a)
CG11449 36
  • 25 (a)
CG5062 36
  • 17 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 53 (a)
Species with no ortholog for CFAP45:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFAP45 Gene

Gene Tree for CFAP45 (if available)
Gene Tree for CFAP45 (if available)

Paralogs for CFAP45 Gene

No data available for Paralogs for CFAP45 Gene

Variants for CFAP45 Gene

Sequence variations from dbSNP and Humsavar for CFAP45 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type MAF
rs1135326 -- 159,872,559(-) GAGCC(A/C)CTGGC reference, missense
rs1135328 -- 159,872,441(-) AGATT(C/T)TGCCC utr-variant-3-prime
rs2494485 -- 159,901,948(-) ACTCT(A/G)TCATT upstream-variant-2KB
rs2494486 -- 159,900,390(-) TGACC(C/G)AAAAG upstream-variant-2KB
rs2494487 -- 159,896,670(-) TATCT(C/T)CCTGC intron-variant

Relevant External Links for CFAP45 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CFAP45 Gene

Disorders for CFAP45 Gene

No disorders were found for CFAP45 Gene.

No data available for MalaCards , OMIM , UniProtKB/Swiss-Prot , University of Copenhagen DISEASES , Novoseek inferred disease relationships , Genatlas and External Links for CFAP45 Gene

Publications for CFAP45 Gene

  1. Molecular cloning of a novel tissue-specific gene from human nasopharyngeal epithelium. (PMID: 10524255) Li Z. … Cao Y. (Gene 1999) 2 3 4
  2. Decreased expression of updated NESG1 in nasopharyngeal carcinoma: its potential role and preliminarily functional mechanism. (PMID: 20715168) Liu Z. … Fang W. (Int. J. Cancer 2011) 2 3
  3. Potential tumor suppressor NESG1 as an unfavorable prognosis factor in nasopharyngeal carcinoma. (PMID: 22140479) Liu Z. … Fang W. (PLoS ONE 2011) 3
  4. Proteomic features of potential tumor suppressor NESG1 in nasopharyngeal carcinoma. (PMID: 22997098) Liu Z. … Fang W. (Proteomics 2012) 3
  5. Candidate tumour suppressor CCDC19 regulates miR-184 direct targeting of C-Myc thereby suppressing cell growth in non-small cell lung cancers. (PMID: 24976536) Liu Z. … Fang W. (J. Cell. Mol. Med. 2014) 3

Products for CFAP45 Gene

Sources for CFAP45 Gene

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