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Aliases for CFAP45 Gene

Aliases for CFAP45 Gene

  • Cilia And Flagella Associated Protein 45 2 3 5
  • Nasopharyngeal Epithelium-Specific Protein 1 3 4
  • Coiled-Coil Domain Containing 19 2 3
  • CCDC19 3 4
  • NESG1 3 4
  • Coiled-Coil Domain-Containing Protein 19, Mitochondrial 3
  • Nasopharyngeal Epithelium Specific Protein 1 (NESG1) 3
  • Cilia- And Flagella-Associated Protein 45 3
  • Coiled-Coil Domain-Containing Protein 19 4
  • Protein CFAP45, Mitochondrial 3

External Ids for CFAP45 Gene

Previous HGNC Symbols for CFAP45 Gene

  • CCDC19

Summaries for CFAP45 Gene

GeneCards Summary for CFAP45 Gene

CFAP45 (Cilia And Flagella Associated Protein 45) is a Protein Coding gene. Diseases associated with CFAP45 include Pharynx Cancer.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFAP45 Gene

Genomics for CFAP45 Gene

Regulatory Elements for CFAP45 Gene

Enhancers for CFAP45 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH01F159935 1.7 FANTOM5 Ensembl ENCODE 4.4 -41.2 -41159 10.8 HDGF PKNOX1 CREB3L1 SIN3A FEZF1 ZNF2 YY1 ZNF143 FOS ZNF263 ATP1A4 LINC01133 C1orf204 ENSG00000272668 ENSG00000228606 IGSF9 NHLH1 VSIG8 CFAP45 VANGL2
GH01F160187 1.3 Ensembl ENCODE 5.3 -290.6 -290615 6.7 HDGF ATF1 ARNT ZNF133 SIN3A ARID4B GLI4 DMAP1 ZNF48 ZNF2 ENSG00000228606 NCSTN CASQ1 SLAMF8 ACKR1 LOC729867 CADM3-AS1 ATP1A4 CFAP45 COPA
GH01F159898 1.1 Ensembl ENCODE 0.8 +0.0 44 4.1 SREBF2 BMI1 RAD21 SCRT2 FOS EGR2 ZNF217 PBX2 FOXJ2 ZNF24 ENSG00000272668 C1orf204 VSIG8 CFAP45 MIR4259
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CFAP45 on UCSC Golden Path with GeneCards custom track

Genomic Location for CFAP45 Gene

159,872,364 bp from pter
159,900,163 bp from pter
27,800 bases
Minus strand

Genomic View for CFAP45 Gene

Genes around CFAP45 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CFAP45 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CFAP45 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFAP45 Gene

Proteins for CFAP45 Gene

  • Protein details for CFAP45 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Cilia- and flagella-associated protein 45
    Protein Accession:
    Secondary Accessions:
    • C9JH28
    • Q05BA3
    • Q5VU18

    Protein attributes for CFAP45 Gene

    551 amino acids
    Molecular mass:
    65730 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAD55817.1; Type=Erroneous initiation; Note=Translation N-terminally extended.; Evidence={ECO:0000305}; Sequence=AAD55817.1; Type=Frameshift; Positions=441; Evidence={ECO:0000305};

    Alternative splice isoforms for CFAP45 Gene


neXtProt entry for CFAP45 Gene

Post-translational modifications for CFAP45 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CFAP45 Gene

No data available for DME Specific Peptides for CFAP45 Gene

Domains & Families for CFAP45 Gene

Protein Domains for CFAP45 Gene


Suggested Antigen Peptide Sequences for CFAP45 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the CFAP45 family.
  • Belongs to the CFAP45 family.
genes like me logo Genes that share domains with CFAP45: view

No data available for Gene Families for CFAP45 Gene

Function for CFAP45 Gene

Phenotypes for CFAP45 Gene

genes like me logo Genes that share phenotypes with CFAP45: view

Animal Model Products

miRNA for CFAP45 Gene

miRTarBase miRNAs that target CFAP45

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CFAP45 Gene

Localization for CFAP45 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFAP45 Gene

Cell projection, cilium.

Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CFAP45 gene
Compartment Confidence
nucleus 5
mitochondrion 3
cytosol 1

Gene Ontology (GO) - Cellular Components for CFAP45 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus NAS 10524255
GO:0005654 nucleoplasm IDA --
GO:0005929 cilium IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with CFAP45: view

Pathways & Interactions for CFAP45 Gene

SuperPathways for CFAP45 Gene

No Data Available

Interacting Proteins for CFAP45 Gene

Gene Ontology (GO) - Biological Process for CFAP45 Gene


No data available for Pathways by source and SIGNOR curated interactions for CFAP45 Gene

Transcripts for CFAP45 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CFAP45 Gene

No ASD Table

Relevant External Links for CFAP45 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CFAP45 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CFAP45 Gene

Protein differential expression in normal tissues from HIPED for CFAP45 Gene

This gene is overexpressed in Plasma (48.9) and Liver, secretome (15.5).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB and MOPED for CFAP45 Gene

Protein tissue co-expression partners for CFAP45 Gene

NURSA nuclear receptor signaling pathways regulating expression of CFAP45 Gene:


mRNA Expression by UniProt/SwissProt for CFAP45 Gene:

Tissue specificity: Expressed in nasopharyngeal epithelium and trachea but not in esophagus, stomach, large intestine, liver, cerebrum, heart, bladder, kidney, thymus, or lung.
genes like me logo Genes that share expression patterns with CFAP45: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CFAP45 Gene

Orthologs for CFAP45 Gene

This gene was present in the common ancestor of animals.

Orthologs for CFAP45 Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CCDC19 34 35
  • 90.98 (n)
(Bos Taurus)
Mammalia CCDC19 34 35
  • 89.44 (n)
(Rattus norvegicus)
Mammalia Ccdc19 34
  • 85.77 (n)
(Mus musculus)
Mammalia Ccdc19 34 35
  • 84.75 (n)
Cfap45 16
(Canis familiaris)
Mammalia CCDC19 34 35
  • 84.46 (n)
(Monodelphis domestica)
Mammalia CCDC19 35
  • 65 (a)
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 52 (a)
-- 35
  • 47 (a)
(Gallus gallus)
Aves CCDC19 34 35
  • 65.86 (n)
(Anolis carolinensis)
Reptilia CCDC19 35
  • 57 (a)
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc19 34
  • 64.5 (n)
MGC76242 34
(Danio rerio)
Actinopterygii ccdc19 34 35
  • 57.02 (n)
wufc64b08 34
fruit fly
(Drosophila melanogaster)
Insecta CG11449 34 35
  • 45.46 (n)
CG5062 35
  • 17 (a)
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP001112 34
  • 43.09 (n)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 53 (a)
Species where no ortholog for CFAP45 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFAP45 Gene

Gene Tree for CFAP45 (if available)
Gene Tree for CFAP45 (if available)

Paralogs for CFAP45 Gene

No data available for Paralogs for CFAP45 Gene

Variants for CFAP45 Gene

Sequence variations from dbSNP and Humsavar for CFAP45 Gene

SNP ID Clin Chr 01 pos Sequence Context AA Info Type
rs10752631 -- 159,892,363(+) CAGAG(C/T)GAGAG intron-variant
rs10908747 -- 159,883,507(+) GGTGA(C/T)AATGG intron-variant
rs10908748 -- 159,883,625(+) TAAAA(A/T)ATATA intron-variant
rs111777928 -- 159,897,208(+) GCAGT(A/G)AGCCA intron-variant
rs111792999 -- 159,874,657(+) CAGGC(A/G)GTTGA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CFAP45 Gene

Variant ID Type Subtype PubMed ID
nsv548052 CNV gain 21841781
nsv464150 CNV gain 19166990
nsv1005195 CNV gain 25217958
esv3578218 CNV loss 25503493

Variation tolerance for CFAP45 Gene

Residual Variation Intolerance Score: 93.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.53; 82.34% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CFAP45 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CFAP45 Gene

Disorders for CFAP45 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CFAP45 Gene - From: DISEASES

Disorder Aliases PubMed IDs
pharynx cancer
  • pharyngeal cancer
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CFAP45

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CFAP45: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CFAP45 Gene

Publications for CFAP45 Gene

  1. Molecular cloning of a novel tissue-specific gene from human nasopharyngeal epithelium. (PMID: 10524255) Li Z. … Cao Y. (Gene 1999) 2 3 4 64
  2. Decreased expression of updated NESG1 in nasopharyngeal carcinoma: its potential role and preliminarily functional mechanism. (PMID: 20715168) Liu Z. … Fang W. (Int. J. Cancer 2011) 2 3 64
  3. Panorama of ancient metazoan macromolecular complexes. (PMID: 26344197) Wan C. … Emili A. (Nature 2015) 3 64
  4. Candidate tumour suppressor CCDC19 regulates miR-184 direct targeting of C-Myc thereby suppressing cell growth in non-small cell lung cancers. (PMID: 24976536) Liu Z. … Fang W. (J. Cell. Mol. Med. 2014) 3 64
  5. Proteomic features of potential tumor suppressor NESG1 in nasopharyngeal carcinoma. (PMID: 22997098) Liu Z. … Fang W. (Proteomics 2012) 3 64

Products for CFAP45 Gene

Sources for CFAP45 Gene

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