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Aliases for CFAP36 Gene

Aliases for CFAP36 Gene

  • Cilia And Flagella Associated Protein 36 2 3
  • Coiled-Coil Domain-Containing Protein 104 3 4
  • Coiled-Coil Domain Containing 104 2 3
  • CCDC104 3 4

External Ids for CFAP36 Gene

Previous HGNC Symbols for CFAP36 Gene

  • CCDC104

Summaries for CFAP36 Gene

GeneCards Summary for CFAP36 Gene

CFAP36 (Cilia And Flagella Associated Protein 36) is a Protein Coding gene.

UniProtKB/Swiss-Prot for CFAP36 Gene

  • May act as an effector for ARL3

No data available for Entrez Gene Summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFAP36 Gene

Genomics for CFAP36 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CFAP36 Gene

Chromosome:
2
Start:
55,519,595 bp from pter
End:
55,545,879 bp from pter
Size:
26,285 bases
Orientation:
Plus strand

Genomic View for CFAP36 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CFAP36 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFAP36 Gene

No data available for Regulatory Elements for CFAP36 Gene

Proteins for CFAP36 Gene

  • Protein details for CFAP36 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q96G28-CFA36_HUMAN
    Recommended name:
    Cilia- and flagella-associated protein 36
    Protein Accession:
    Q96G28
    Secondary Accessions:
    • Q53SF0
    • Q53ST9
    • Q6UY34

    Protein attributes for CFAP36 Gene

    Size:
    342 amino acids
    Molecular mass:
    39447 Da
    Quaternary structure:
    • Interacts with ARL3.

    Alternative splice isoforms for CFAP36 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CFAP36 Gene

Proteomics data for CFAP36 Gene at MOPED

Post-translational modifications for CFAP36 Gene

  • Ubiquitination at Lys 63, Lys 70, Lys 89, Lys 110, Lys 116, Lys 155, Lys 282, Lys 293, Lys 303, Lys 334, and Lys 336
  • Modification sites at PhosphoSitePlus

Other Protein References for CFAP36 Gene

No data available for DME Specific Peptides for CFAP36 Gene

Domains & Families for CFAP36 Gene

Protein Domains for CFAP36 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CFAP36 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q96G28

UniProtKB/Swiss-Prot:

CFA36_HUMAN :
  • Belongs to the CFAP36 family.
Family:
  • Belongs to the CFAP36 family.
genes like me logo Genes that share domains with CFAP36: view

No data available for Gene Families for CFAP36 Gene

Function for CFAP36 Gene

Molecular function for CFAP36 Gene

UniProtKB/Swiss-Prot Function:
May act as an effector for ARL3

Gene Ontology (GO) - Molecular Function for CFAP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005515 protein binding --
genes like me logo Genes that share ontologies with CFAP36: view

Phenotypes for CFAP36 Gene

genes like me logo Genes that share phenotypes with CFAP36: view

miRNA for CFAP36 Gene

miRTarBase miRNAs that target CFAP36

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CFAP36

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Animal Models , Transcription Factor Targets and HOMER Transcription for CFAP36 Gene

Localization for CFAP36 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFAP36 Gene

Nucleus. Cytoplasm. Cell projection, cilium, flagellum.

Gene Ontology (GO) - Cellular Components for CFAP36 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005634 nucleus IEA --
GO:0005737 cytoplasm IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with CFAP36: view

No data available for Subcellular locations from COMPARTMENTS for CFAP36 Gene

Pathways & Interactions for CFAP36 Gene

SuperPathways for CFAP36 Gene

No Data Available

Interacting Proteins for CFAP36 Gene

Gene Ontology (GO) - Biological Process for CFAP36 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CFAP36 Gene

Drugs & Compounds for CFAP36 Gene

No Compound Related Data Available

Transcripts for CFAP36 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CFAP36

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CFAP36 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3 ^ 4a · 4b ^ 5a · 5b ^ 6 ^ 7 ^ 8a · 8b ^ 9 ^ 10 ^ 11a · 11b ^ 12
SP1: - - - -
SP2: - - - - -
SP3: -
SP4: - - -
SP5: -
SP6: - - -

Relevant External Links for CFAP36 Gene

GeneLoc Exon Structure for
CFAP36
ECgene alternative splicing isoforms for
CFAP36

Expression for CFAP36 Gene

mRNA expression in normal human tissues for CFAP36 Gene

Protein differential expression in normal tissues from HIPED for CFAP36 Gene

This gene is overexpressed in Testis (10.8), Fetal Brain (8.7), Ovary (8.2), Gallbladder (7.2), CD8 Tcells (6.5), and Fetal ovary (6.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CFAP36 Gene



mRNA Expression by UniProt/SwissProt for CFAP36 Gene

Q96G28-CFA36_HUMAN
Tissue specificity: Expressed in several human tissues including brain, testis, heart, lung, pancreas and spleen (at protein level).
genes like me logo Genes that share expression patterns with CFAP36: view

Protein tissue co-expression partners for CFAP36 Gene

- Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA differential expression in normal tissues for CFAP36 Gene

Orthologs for CFAP36 Gene

This gene was present in the common ancestor of animals.

Orthologs for CFAP36 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CCDC104 35
  • 91.91 (n)
  • 91.37 (a)
CCDC104 36
  • 91 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CCDC104 35
  • 93.7 (n)
  • 92.68 (a)
CCDC104 36
  • 87 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ccdc104 35
  • 88.5 (n)
  • 90.94 (a)
Ccdc104 16
Ccdc104 36
  • 91 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CCDC104 35
  • 99.61 (n)
  • 99.12 (a)
CCDC104 36
  • 99 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ccdc104 35
  • 87.33 (n)
  • 90.06 (a)
oppossum
(Monodelphis domestica)
Mammalia CCDC104 36
  • 72 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CCDC104 36
  • 70 (a)
OneToOne
chicken
(Gallus gallus)
Aves CCDC104 35
  • 66.25 (n)
  • 58.31 (a)
CCDC104 36
  • 54 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CCDC104 36
  • 61 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia ccdc104 35
  • 61.72 (n)
  • 52.26 (a)
MGC76095 35
African clawed frog
(Xenopus laevis)
Amphibia mgc15407-prov 35
zebrafish
(Danio rerio)
Actinopterygii ccdc104 35
  • 52.87 (n)
  • 49.34 (a)
ccdc104 36
  • 39 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG14367 36
  • 26 (a)
OneToOne
worm
(Caenorhabditis elegans)
Secernentea Y108G3AL.3 36
  • 12 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea CSA.2835 36
  • 17 (a)
OneToOne
Species with no ortholog for CFAP36:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CFAP36 Gene

ENSEMBL:
Gene Tree for CFAP36 (if available)
TreeFam:
Gene Tree for CFAP36 (if available)

Paralogs for CFAP36 Gene

No data available for Paralogs for CFAP36 Gene

Variants for CFAP36 Gene

Sequence variations from dbSNP and Humsavar for CFAP36 Gene

SNP ID Clin Chr 02 pos Sequence Context AA Info Type MAF
rs1045910 - 55,544,025(+) AAAAG(A/G)CCTGA reference, missense
rs1045920 - 55,544,033(+) TGAAG(A/G/T)TTCCT reference, missense
rs1128735 -- 55,544,355(+) AACCC(A/C)CTGGG reference, missense
rs1318672 -- 55,541,747(+) AATCA(G/T)AAAGG intron-variant
rs1867334 -- 55,533,469(+) TAGGC(C/T)GAGGG intron-variant

Variation tolerance for CFAP36 Gene

Residual Variation Intolerance Score: 47.41% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.76; 78.90% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CFAP36 Gene

HapMap Linkage Disequilibrium report
CFAP36

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CFAP36 Gene

Disorders for CFAP36 Gene

Relevant External Links for CFAP36

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CFAP36
genes like me logo Genes that share disorders with CFAP36: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CFAP36 Gene

Publications for CFAP36 Gene

  1. Antibody to CCDC104 is associated with a paraneoplastic antibody to CDR2 (anti-Yo). (PMID: 19680650) Totland C. … Vedeler C.A. (Cancer Immunol. Immunother. 2010) 2 67
  2. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 67
  3. An ARL3-UNC119-RP2 GTPase cycle targets myristoylated NPHP3 to the primary cilium. (PMID: 22085962) Wright K.J. … Jackson P.K. (Genes Dev. 2011) 67
  4. A human MAP kinase interactome. (PMID: 20936779) Bandyopadhyay S. … Ideker T. (Nat. Methods 2010) 67
  5. Lys-N and trypsin cover complementary parts of the phosphoproteome in a refined SCX-based approach. (PMID: 19413330) Gauci S. … Mohammed S. (Anal. Chem. 2009) 67

Products for CFAP36 Gene

Sources for CFAP36 Gene

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