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Aliases for CFAP161 Gene

Aliases for CFAP161 Gene

  • Cilia And Flagella Associated Protein 161 2 3 5
  • C15orf26 3 4
  • Cilia- And Flagella-Associated Protein 161 3
  • Chromosome 15 Open Reading Frame 26 2

External Ids for CFAP161 Gene

Previous HGNC Symbols for CFAP161 Gene

  • C15orf26

Summaries for CFAP161 Gene

GeneCards Summary for CFAP161 Gene

CFAP161 (Cilia And Flagella Associated Protein 161) is a Protein Coding gene. Diseases associated with CFAP161 include Primary Ciliary Dyskinesia.

UniProtKB/Swiss-Prot for CFAP161 Gene

  • May play a role in motile cilia function, possibly by acting on dynein arm assembly.

Additional gene information for CFAP161 Gene

No data available for Entrez Gene Summary , CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFAP161 Gene

Genomics for CFAP161 Gene

Regulatory Elements for CFAP161 Gene

Enhancers for CFAP161 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH15H081235 1 Ensembl ENCODE 11.3 +229.2 229168 1 ATF1 L3MBTL2 BHLHE40 MAFG BACH1 FOSL1 ZNF316 JUND FOS NFE2 CFAP161 IL16 GC15M081220 GC15P081268
GH15H081134 0.8 ENCODE 7.2 +127.2 127203 0 CTCF MXI1 MAX BMI1 ZIC2 ZEB1 GLIS2 POLR2A PATZ1 ZNF600 CFAP161 GC15P081140 GC15P081120
GH15H081004 0.5 Ensembl dbSUPER 0.7 -2.0 -2033 0 TLNRD1 PIR45812 CFAP161
GH15H081014 0.5 dbSUPER 0.4 +9.4 9382 4 NFYB NR2F1 USF2 EBF1 MESD CFAP161 GC15P081022
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CFAP161 on UCSC Golden Path with GeneCards custom track

Genomic Location for CFAP161 Gene

Chromosome:
15
Start:
81,007,033 bp from pter
End:
81,149,175 bp from pter
Size:
142,143 bases
Orientation:
Plus strand

Genomic View for CFAP161 Gene

Genes around CFAP161 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CFAP161 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CFAP161 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFAP161 Gene

Proteins for CFAP161 Gene

  • Protein details for CFAP161 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6P656-CF161_HUMAN
    Recommended name:
    Cilia- and flagella-associated protein 161
    Protein Accession:
    Q6P656
    Secondary Accessions:
    • Q8N906

    Protein attributes for CFAP161 Gene

    Size:
    301 amino acids
    Molecular mass:
    34294 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CFAP161 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CFAP161 Gene

Post-translational modifications for CFAP161 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CFAP161 Gene

No data available for DME Specific Peptides for CFAP161 Gene

Domains & Families for CFAP161 Gene

Gene Families for CFAP161 Gene

HGNC:
Human Protein Atlas (HPA):
  • Predicted intracellular proteins

Protein Domains for CFAP161 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

genes like me logo Genes that share domains with CFAP161: view

No data available for Suggested Antigen Peptide Sequences and UniProtKB/Swiss-Prot for CFAP161 Gene

Function for CFAP161 Gene

Molecular function for CFAP161 Gene

UniProtKB/Swiss-Prot Function:
May play a role in motile cilia function, possibly by acting on dynein arm assembly.
genes like me logo Genes that share phenotypes with CFAP161: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CFAP161
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Phenotypes From GWAS Catalog , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CFAP161 Gene

Localization for CFAP161 Gene

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CFAP161 gene
Compartment Confidence
cytosol 2

No data available for Subcellular locations from UniProtKB/Swiss-Prot , Subcellular locations from the Human Protein Atlas (HPA) and Gene Ontology (GO) - Cellular Components for CFAP161 Gene

Pathways & Interactions for CFAP161 Gene

SuperPathways for CFAP161 Gene

No Data Available

Interacting Proteins for CFAP161 Gene

Gene Ontology (GO) - Biological Process for CFAP161 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CFAP161 Gene

Drugs & Compounds for CFAP161 Gene

No Compound Related Data Available

Transcripts for CFAP161 Gene

mRNA/cDNA for CFAP161 Gene

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CFAP161
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CFAP161 Gene

No ASD Table

Relevant External Links for CFAP161 Gene

GeneLoc Exon Structure for
CFAP161
ECgene alternative splicing isoforms for
CFAP161

Expression for CFAP161 Gene

NURSA nuclear receptor signaling pathways regulating expression of CFAP161 Gene:

CFAP161
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners , mRNA Expression by UniProt/SwissProt , Evidence on tissue expression from TISSUES and Phenotype-based relationships between genes and organs from Gene ORGANizer for CFAP161 Gene

Orthologs for CFAP161 Gene

This gene was present in the common ancestor of animals.

Orthologs for CFAP161 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C15H15orf26 33
  • 99.22 (n)
C15orf26 34
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C3H15orf26 33
  • 85.31 (n)
C15orf26 34
  • 75 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C21H15orf26 33
  • 84.79 (n)
C21H15ORF26 34
  • 72 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia RGD1310371 33
  • 77 (n)
mouse
(Mus musculus)
Mammalia 1700026D08Rik 33 34
  • 76.89 (n)
Cfap161 16
oppossum
(Monodelphis domestica)
Mammalia C15orf26 34
  • 55 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia C15orf26 34
  • 44 (a)
OneToOne
chicken
(Gallus gallus)
Aves C10H15ORF26 33
  • 60.71 (n)
C15orf26 34
  • 49 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia C15orf26 34
  • 53 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia c15orf26 33
  • 58.3 (n)
zebrafish
(Danio rerio)
Actinopterygii zgc:110373 33
  • 54.02 (n)
C18H15orf26 34
  • 41 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG34457 33 34
  • 44.06 (n)
CG15498 34
  • 27 (a)
OneToMany
sea squirt
(Ciona savignyi)
Ascidiacea CSA.10116 34
  • 42 (a)
OneToOne
Species where no ortholog for CFAP161 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFAP161 Gene

ENSEMBL:
Gene Tree for CFAP161 (if available)
TreeFam:
Gene Tree for CFAP161 (if available)

Paralogs for CFAP161 Gene

No data available for Paralogs for CFAP161 Gene

Variants for CFAP161 Gene

Sequence variations from dbSNP and Humsavar for CFAP161 Gene

SNP ID Clin Chr 15 pos Sequence Context AA Info Type
rs1000118350 -- 81,146,406(+) TGCTT(A/C)TCATT intron-variant
rs1000179714 -- 81,126,775(+) ATCAG(A/G)GTTGT intron-variant
rs1000190643 -- 81,114,716(+) TGGAG(G/T)GCAGT intron-variant
rs1000245362 -- 81,120,439(+) AGCAT(C/T)AGGTC intron-variant
rs1000296521 -- 81,133,924(+) TGCTG(A/C)TGATT intron-variant, upstream-variant-2KB

Variation tolerance for CFAP161 Gene

Residual Variation Intolerance Score: 30% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.35; 63.27% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CFAP161 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CFAP161

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CFAP161 Gene

Disorders for CFAP161 Gene

MalaCards: The human disease database

(1) MalaCards diseases for CFAP161 Gene - From: DISEASES and GeneCards

Disorder Aliases PubMed IDs
primary ciliary dyskinesia
  • kartagener syndrome
- elite association - COSMIC cancer census association via MalaCards

Relevant External Links for CFAP161

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CFAP161
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CFAP161
genes like me logo Genes that share disorders with CFAP161: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CFAP161 Gene

Publications for CFAP161 Gene

  1. Zebrafish Ciliopathy Screen Plus Human Mutational Analysis Identifies C21orf59 and CCDC65 Defects as Causing Primary Ciliary Dyskinesia. (PMID: 24094744) Austin-Tse C … Hildebrandt F (American journal of human genetics 2013) 2 3 60
  2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T … Sugano S (Nature genetics 2004) 3 4 60
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard DS … MGC Project Team (Genome research 2004) 3 4 60
  4. An organelle-specific protein landscape identifies novel diseases and molecular mechanisms. (PMID: 27173435) Boldt K … UK10K Rare Diseases Group (Nature communications 2016) 3 60
  5. Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. (PMID: 12477932) Strausberg RL … Mammalian Gene Collection Program Team (Proceedings of the National Academy of Sciences of the United States of America 2002) 3 60

Products for CFAP161 Gene

Sources for CFAP161 Gene

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