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Aliases for CFAP157 Gene

Aliases for CFAP157 Gene

  • Cilia And Flagella Associated Protein 157 2 3 5
  • C9orf117 3 4
  • Cilia- And Flagella-Associated Protein 157 3
  • Chromosome 9 Open Reading Frame 117 2

External Ids for CFAP157 Gene

Previous HGNC Symbols for CFAP157 Gene

  • C9orf117

Summaries for CFAP157 Gene

GeneCards Summary for CFAP157 Gene

CFAP157 (Cilia And Flagella Associated Protein 157) is a Protein Coding gene.

No data available for Entrez Gene Summary , UniProtKB/Swiss-Prot , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CFAP157 Gene

Genomics for CFAP157 Gene

Regulatory Elements for CFAP157 Gene

Enhancers for CFAP157 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH09F127582 1.2 Ensembl ENCODE 11 -122.1 -122084 4.2 PKNOX1 ARID4B YBX1 ZNF2 BRCA1 GLIS2 ZNF207 ZNF143 DEK ZNF202 SNORA65 ZNF79 PTRH1 TTC16 CFAP157 ST6GALNAC4 PIP5KL1 URM1 ENG NAIF1
GH09F127628 1.1 Ensembl ENCODE 11.7 -77.6 -77567 2.0 TBP PKNOX1 RAD21 EGR2 ZBTB11 SMARCA4 PBX2 IKZF1 HMBOX1 PRDM1 TTC16 FAM129B CFAP157 GC09M127606 MIR3911
GH09F127637 1.1 Ensembl ENCODE 11.3 -69.3 -69253 1.0 TBP HDAC1 PKNOX1 JUN MAX CEBPG RFX5 ZNF366 POLR3A SCRT2 STXBP1 TTC16 CFAP157 FAM129B GC09M127606 MIR3911
GH09F127589 1.1 Ensembl ENCODE 11.3 -116.9 -116887 0.6 GTF2F1 CTCF MXI1 SAP130 ARID4B MAX ZIC2 RAD21 RFX5 TEAD3 TTC16 PTRH1 CFAP157 STXBP1 GC09M127606
GH09F127682 1 ENCODE 12.4 -22.9 -22870 2.5 ATF1 CREB3L1 ARID4B SIN3A GLI4 FEZF1 YY1 GLIS2 FOS DEK CFAP157 TTC16 FAM129B TOR2A MIR3911 GC09M127606
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CFAP157 on UCSC Golden Path with GeneCards custom track

Genomic Location for CFAP157 Gene

Chromosome:
9
Start:
127,706,988 bp from pter
End:
127,716,002 bp from pter
Size:
9,015 bases
Orientation:
Plus strand

Genomic View for CFAP157 Gene

Genes around CFAP157 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CFAP157 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CFAP157 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CFAP157 Gene

Proteins for CFAP157 Gene

  • Protein details for CFAP157 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q5JU67-CF157_HUMAN
    Recommended name:
    Cilia- and flagella-associated protein 157
    Protein Accession:
    Q5JU67
    Secondary Accessions:
    • A5D8T9

    Protein attributes for CFAP157 Gene

    Size:
    520 amino acids
    Molecular mass:
    60533 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CFAP157 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CFAP157 Gene

Post-translational modifications for CFAP157 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CFAP157 Gene

No data available for DME Specific Peptides for CFAP157 Gene

Domains & Families for CFAP157 Gene

Protein Domains for CFAP157 Gene

ProtoNet:

Graphical View of Domain Structure for InterPro Entry

Q5JU67

UniProtKB/Swiss-Prot:

CF157_HUMAN :
  • Belongs to the CFAP157 family.
Family:
  • Belongs to the CFAP157 family.
genes like me logo Genes that share domains with CFAP157: view

No data available for Gene Families and Suggested Antigen Peptide Sequences for CFAP157 Gene

Function for CFAP157 Gene

genes like me logo Genes that share phenotypes with CFAP157: view

Animal Model Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Molecular function , Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CFAP157 Gene

Localization for CFAP157 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CFAP157 Gene

Cell projection, cilium.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CFAP157 gene
Compartment Confidence
plasma membrane 5
cytosol 5
nucleus 3

Gene Ontology (GO) - Cellular Components for CFAP157 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005929 cilium IEA --
GO:0042995 cell projection IEA --
genes like me logo Genes that share ontologies with CFAP157: view

Pathways & Interactions for CFAP157 Gene

SuperPathways for CFAP157 Gene

No Data Available

Interacting Proteins for CFAP157 Gene

Selected Interacting proteins: Q5JU67-CF157_HUMAN for CFAP157 Gene via IID

Symbol External ID(s) Details
CUL4B

Gene Ontology (GO) - Biological Process for CFAP157 Gene

None

No data available for Pathways by source and SIGNOR curated interactions for CFAP157 Gene

Transcripts for CFAP157 Gene

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CFAP157 Gene

No ASD Table

Relevant External Links for CFAP157 Gene

GeneLoc Exon Structure for
CFAP157
ECgene alternative splicing isoforms for
CFAP157

Expression for CFAP157 Gene

NURSA nuclear receptor signaling pathways regulating expression of CFAP157 Gene:

CFAP157
No Expression Related Data Available

Primer Products

No data available for mRNA expression in normal human tissues , mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA differential expression in normal tissues , Protein differential expression in normal tissues , Protein expression , Protein tissue co-expression partners and mRNA Expression by UniProt/SwissProt for CFAP157 Gene

Orthologs for CFAP157 Gene

This gene was present in the common ancestor of animals.

Orthologs for CFAP157 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia C9H9orf117 34
  • 99.1 (n)
C9orf117 35
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia C11H9orf117 34
  • 81.88 (n)
C9orf117 35
  • 71 (a)
OneToOne
dog
(Canis familiaris)
Mammalia C9H9orf117 34
  • 81.88 (n)
C9orf117 35
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia 1700019L03Rik 34 35
  • 77.17 (n)
Cfap157 16
rat
(Rattus norvegicus)
Mammalia LOC499781 34
  • 76.41 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia C9orf117 35
  • 58 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 56 (a)
OneToMany
-- 35
  • 33 (a)
OneToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia c9orf117 34
  • 55.8 (n)
zebrafish
(Danio rerio)
Actinopterygii si:ch211-233f10.4 34
  • 51.41 (n)
C5H9orf117 35
  • 36 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG17122 35
  • 17 (a)
OneToOne
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 36 (a)
OneToOne
Species where no ortholog for CFAP157 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CFAP157 Gene

ENSEMBL:
Gene Tree for CFAP157 (if available)
TreeFam:
Gene Tree for CFAP157 (if available)

Paralogs for CFAP157 Gene

No data available for Paralogs for CFAP157 Gene

Variants for CFAP157 Gene

Sequence variations from dbSNP and Humsavar for CFAP157 Gene

SNP ID Clin Chr 09 pos Sequence Context AA Info Type
rs10851 -- 127,714,232(+) TGAAC(A/C/T)GCCTC intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, synonymous-codon, missense, utr-variant-3-prime
rs111378450 -- 127,714,251(+) CCGGG(A/C/T)GCCCG intron-variant, downstream-variant-500B, upstream-variant-2KB, reference, synonymous-codon, missense
rs111641093 -- 127,710,483(+) CCCAC(A/T)GAGAC intron-variant
rs111737622 -- 127,709,323(+) ATGCC(A/C)CTTTA intron-variant
rs111957170 -- 127,712,008(+) CTGGC(C/T)CAGCT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CFAP157 Gene

Variant ID Type Subtype PubMed ID
nsv466571 CNV loss 19166990
nsv615369 CNV loss 21841781

Variation tolerance for CFAP157 Gene

Residual Variation Intolerance Score: 87.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.02; 50.09% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CFAP157 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CFAP157

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CFAP157 Gene

Disorders for CFAP157 Gene

Relevant External Links for CFAP157

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CFAP157
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CFAP157

No disorders were found for CFAP157 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CFAP157 Gene

Publications for CFAP157 Gene

  1. Transcriptional program of ciliated epithelial cells reveals new cilium and centrosome components and links to human disease. (PMID: 23300604) Hoh R.A. … Stearns T. (PLoS ONE 2012) 2 3 64
  2. Dynamics of cullin-RING ubiquitin ligase network revealed by systematic quantitative proteomics. (PMID: 21145461) Bennett E.J. … Harper J.W. (Cell 2010) 3 64
  3. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 64
  4. DNA sequence and analysis of human chromosome 9. (PMID: 15164053) Humphray S.J. … Dunham I. (Nature 2004) 4 64
  5. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 4 64

Products for CFAP157 Gene

Sources for CFAP157 Gene

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