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Aliases for CETP Gene

Aliases for CETP Gene

  • Cholesteryl Ester Transfer Protein 2 3 5
  • BPI Fold Containing Family F 2 3
  • Lipid Transfer Protein I 3 4
  • Cholesteryl Ester Transfer Protein, Plasma 2
  • Cholesteryl Ester Transfer Protein Plasma 3
  • HDLCQ10 3
  • BPIFF 3

External Ids for CETP Gene

Previous GeneCards Identifiers for CETP Gene

  • GC16M047282
  • GC16P057046
  • GC16P056730
  • GC16P056771
  • GC16P055553
  • GC16P042865

Summaries for CETP Gene

Entrez Gene Summary for CETP Gene

  • The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

GeneCards Summary for CETP Gene

CETP (Cholesteryl Ester Transfer Protein) is a Protein Coding gene. Diseases associated with CETP include Hyperalphalipoproteinemia and Cetp-Related Hyperalphalipoproteinemia. Among its related pathways are Statin Pathway and Metabolism. GO annotations related to this gene include lipid binding and lipid transporter activity.

UniProtKB/Swiss-Prot for CETP Gene

  • Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796).

Tocris Summary for CETP Gene

  • When glucose supplies are low, the body is able to draw upon lipids as an alternative energy source. Lipids are generally stored as triglycerides and the first step in lipid metabolism is the conversion to glycerol and fatty acids which then enter the Krebs cycle.

Gene Wiki entry for CETP Gene

Additional gene information for CETP Gene

No data available for CIViC summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CETP Gene

Genomics for CETP Gene

Regulatory Elements for CETP Gene

Enhancers for CETP Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16H056997 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12.3 +38.0 38049 4 BCOR HDGF PKNOX1 KLF1 RB1 ZMYM3 EBF1 RELA FOSL1 POLR2A CETP NLRC5 CCDC102A GC16M057013
GH16H057035 1.7 FANTOM5 Ensembl ENCODE dbSUPER 11.2 +77.7 77681 8 HDGF TBL1XR1 RB1 ZNF133 BMI1 YBX1 BATF ZNF143 ATF7 ETV6 NLRC5 CETP LOC100130044 MT1E FAM192A GC16P057038 GC16P057053
GH16H056930 1.4 ENCODE dbSUPER 11.8 -26.3 -26332 10 MLX FEZF1 DMAP1 YY1 SLC30A9 ZNF416 ZNF143 SP3 NFYC ZFP41 RSPRY1 NUDT21 POLR2C NUP93 CETP SLC12A3 LOC105371286 ENSG00000261270 CCDC102A NLRC5
GH16H057167 1.2 Ensembl ENCODE dbSUPER 11.4 +206.2 206180 0 CTCF ZNF654 RB1 TRIM22 MAX REST ZNF398 RAD21 TARDBP SMC3 CETP RSPRY1 ENSG00000279019
GH16H057069 1.2 Ensembl ENCODE dbSUPER 11.2 +109.7 109735 3 HDGF RFX1 NR2F1 ZNF10 USF2 ZNF223 ZFHX2 RBAK TARDBP NR2C1 RSPRY1 CPNE2 NLRC5 CETP FAM192A ENSG00000260145 ENSG00000260148
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CETP on UCSC Golden Path with GeneCards custom track

Genomic Location for CETP Gene

Chromosome:
16
Start:
56,961,850 bp from pter
End:
56,983,845 bp from pter
Size:
21,996 bases
Orientation:
Plus strand

Genomic View for CETP Gene

Genes around CETP on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CETP Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CETP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CETP Gene

Proteins for CETP Gene

  • Protein details for CETP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11597-CETP_HUMAN
    Recommended name:
    Cholesteryl ester transfer protein
    Protein Accession:
    P11597
    Secondary Accessions:
    • Q13987
    • Q13988
    • Q53YZ1

    Protein attributes for CETP Gene

    Size:
    493 amino acids
    Molecular mass:
    54756 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CETP Gene

    Alternative splice isoforms for CETP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CETP Gene

Post-translational modifications for CETP Gene

  • Glycosylation at posLast=105105, posLast=257257, Asn358, and Asn413
  • Modification sites at PhosphoSitePlus

Other Protein References for CETP Gene

No data available for DME Specific Peptides for CETP Gene

Domains & Families for CETP Gene

Gene Families for CETP Gene

HGNC:
Human Protein Atlas (HPA):
  • Candidate cardiovascular disease genes
  • Disease related genes
  • Plasma proteins
  • Predicted intracellular proteins
  • Predicted secreted proteins

Graphical View of Domain Structure for InterPro Entry

P11597

UniProtKB/Swiss-Prot:

CETP_HUMAN :
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with CETP: view

Function for CETP Gene

Molecular function for CETP Gene

GENATLAS Biochemistry:
cholesteryl ester transfer protein,plasma,with low homology to LBP expressed in and throughout differentiation of preadypocyte
UniProtKB/Swiss-Prot Function:
Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796).

Phenotypes From GWAS Catalog for CETP Gene

Gene Ontology (GO) - Molecular Function for CETP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005319 lipid transporter activity IDA 2833496
GO:0005548 phospholipid transporter activity IDA 2833496
GO:0008289 lipid binding IDA,IEA 3818596
GO:0015485 cholesterol binding IDA 2833496
GO:0017127 cholesterol transporter activity IDA,IEA 2833496
genes like me logo Genes that share ontologies with CETP: view
genes like me logo Genes that share phenotypes with CETP: view

Human Phenotype Ontology for CETP Gene

HPO Id HPO Name Alternative Ids Definition Synonyms

Animal Model Products

  • Taconic Biosciences Mouse Models for CETP

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CETP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

No data available for Enzyme Numbers (IUBMB) , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CETP Gene

Localization for CETP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CETP Gene

Secreted, extracellular space. Note=Secreted in plasma. {ECO:0000250 UniProtKB:P47896}.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CETP gene
Compartment Confidence
extracellular 5
peroxisome 2
nucleus 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CETP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA,IEA 3104518
GO:0031982 vesicle IDA 2833496
GO:0034364 high-density lipoprotein particle IEA,IDA 3104518
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CETP: view

No data available for Subcellular locations from the Human Protein Atlas (HPA) for CETP Gene

Pathways & Interactions for CETP Gene

genes like me logo Genes that share pathways with CETP: view

Interacting Proteins for CETP Gene

Gene Ontology (GO) - Biological Process for CETP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006629 lipid metabolic process IEA --
GO:0006641 triglyceride metabolic process IDA 2833496
GO:0006810 transport IEA --
GO:0006869 lipid transport IDA 3818596
GO:0008202 steroid metabolic process IEA --
genes like me logo Genes that share ontologies with CETP: view

No data available for SIGNOR curated interactions for CETP Gene

Drugs & Compounds for CETP Gene

(55) Drugs for CETP Gene - From: PharmGKB, ClinicalTrials, ApexBio, DGIdb, Tocris, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
atorvastatin Approved Pharma Competitive, Inhibitor 0
Fluvastatin Approved Pharma Competitive, Inhibitor HMGCR inhibitor 60
Lovastatin Approved, Investigational Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor, Potent HMG-CoA reductase inhibitor 67
Pravastatin Approved Pharma Competitive, Inhibitor 153
Simvastatin Approved Pharma Competitive, Inhibitor HMG-CoA reductase inhibitor 528

(36) Additional Compounds for CETP Gene - From: Novoseek, HMDB, and Tocris

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Triglycerides Group B
  • 1-Myristoyl-2-myristoyl-3-arachidonyl-glycerol
  • 1-Tetradecanoyl-2-tetradecanoyl-3-eicosanoyl-glycerol
  • TAG(14:0/14:0/20:0)
  • TAG(48:0)
  • TG(48:0)
555-45-3, 30719-27-8, 2190-24-1, 18641-57-1, 56933-26-7
Triglycerides Group D
  • 1-Stearoyl-2-stearoyl-3-stearoyl-glycerol
  • TAG(18:0/18:0/18:0)
  • TAG(54:0)
  • TG(18:0/18:0/18:0)
  • TG(54:0)
(+-)-Octanoylcarnitine chloride
18822-86-1
LDN 193188
1267610-30-9
SC 26196
218136-59-5

(5) Tocris Compounds for CETP Gene

Compound Action Cas Number
(+-)-Octanoylcarnitine chloride Intermediate in lipid metabolism 18822-86-1
BMS 309403 Potent and selective FABP4 inhibitor 300657-03-8
LDN 193188 Inhibitor of phosphatidylcholine transfer protein (PC-TP) 1267610-30-9
RHC 80267 Diacylglycerol lipase inhibitor 83654-05-1
SC 26196 Selective delta6 desaturase inhibitor 218136-59-5

(4) ApexBio Compounds for CETP Gene

Compound Action Cas Number
Anacetrapib (MK-0859) RhCETP/mutant CETP(C13S) inhibitor 875446-37-0
Dalcetrapib (JTT-705, RO4607381) rhCETP inhibitor 211513-37-0
Evacetrapib (LY2484595) CETP inhibitor,potent and selective 1186486-62-3
Torcetrapib CETP inhibitor 262352-17-0
genes like me logo Genes that share compounds with CETP: view

Drug Products

Transcripts for CETP Gene

Unigene Clusters for CETP Gene

Cholesteryl ester transfer protein, plasma:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Applied Biological Materials Clones for CETP
  • Vectors and viruses for ORF, Lenti, Retro, Adenovirus, AAV, and more

Alternative Splicing Database (ASD) splice patterns (SP) for CETP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1:
SP2: -

Relevant External Links for CETP Gene

GeneLoc Exon Structure for
CETP
ECgene alternative splicing isoforms for
CETP

Expression for CETP Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CETP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CETP Gene

This gene is overexpressed in Spleen (x16.8) and Adipose - Visceral (Omentum) (x6.8).

Protein differential expression in normal tissues from HIPED for CETP Gene

This gene is overexpressed in Plasma (31.4), Urine (21.6), and Cervix (12.8).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CETP Gene



Protein tissue co-expression partners for CETP Gene

NURSA nuclear receptor signaling pathways regulating expression of CETP Gene:

CETP

SOURCE GeneReport for Unigene cluster for CETP Gene:

Hs.89538

mRNA Expression by UniProt/SwissProt for CETP Gene:

P11597-CETP_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma.

Evidence on tissue expression from TISSUES for CETP Gene

  • Liver(4.6)
  • Spleen(4.4)
  • Bone marrow(4.1)
  • Pancreas(4)
  • Blood(3)

Phenotype-based relationships between genes and organs from Gene ORGANizer for CETP Gene

Germ Layers:
  • endoderm
  • mesoderm
Systems:
  • cardiovascular
  • digestive
Organs:
Head and neck:
  • ear
Thorax:
  • heart
Abdomen:
  • duodenum
  • intestine
  • liver
  • small intestine
General:
  • blood vessel
genes like me logo Genes that share expression patterns with CETP: view

Primer Products

Orthologs for CETP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CETP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CETP 33 34
  • 99.26 (n)
oppossum
(Monodelphis domestica)
Mammalia CETP 34
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CETP 34
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves CETP 33 34
  • 60.88 (n)
lizard
(Anolis carolinensis)
Reptilia CETP 34
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cetp 33
  • 60.62 (n)
zebrafish
(Danio rerio)
Actinopterygii cetp 33 34
  • 54.07 (n)
Species where no ortholog for CETP was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CETP Gene

ENSEMBL:
Gene Tree for CETP (if available)
TreeFam:
Gene Tree for CETP (if available)

Paralogs for CETP Gene

No data available for Paralogs for CETP Gene

Variants for CETP Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CETP Gene

CETP_HUMAN-P11597
Genetic variations in CETP define the high density lipoprotein cholesterol level quantitative trait locus 10 (HDLCQ10) [MIM:143470].

Sequence variations from dbSNP and Humsavar for CETP Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs142459781 Hyperalphalipoproteinemia 1 (HALP1) [MIM:143470] 56,973,475(+) ATGGC(C/T)GCCTC intron-variant, downstream-variant-500B, reference, missense
rs2303790 other, Hyperalphalipoproteinemia 1 (HALP1) [MIM:143470] 56,983,380(+) CTTCG(A/G)CATCA reference, missense
VAR_033099 Hyperalphalipoproteinemia 1 (HALP1) [MIM:143470]
rs138298866 Likely benign 56,978,126(+) GTCAC(C/T)GTCCA reference, synonymous-codon
rs140547417 Likely benign 56,975,110(+) TGCTG(A/G)AGACC reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CETP Gene

Variant ID Type Subtype PubMed ID
nsv1059098 CNV gain 25217958
nsv524073 CNV loss 19592680
nsv527160 CNV gain 19592680

Variation tolerance for CETP Gene

Residual Variation Intolerance Score: 54.5% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 3.80; 58.35% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CETP Gene

Human Gene Mutation Database (HGMD)
CETP
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CETP

Disorders for CETP Gene

MalaCards: The human disease database

(33) MalaCards diseases for CETP Gene - From: HGMD, OMIM, ClinVar, GeneTests, Orphanet, Swiss-Prot, DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
hyperalphalipoproteinemia
  • cholesterol-ester transfer protein deficiency
cetp-related hyperalphalipoproteinemia
cherry allergy
  • prunus avium fruit allergy
basilar artery insufficiency
  • basilar artery syndrome
coronary stenosis
  • coronary artery stenosis
- elite association - COSMIC cancer census association via MalaCards
Search CETP in MalaCards View complete list of genes associated with diseases

UniProtKB/Swiss-Prot

CETP_HUMAN
  • Hyperalphalipoproteinemia 1 (HALP1) [MIM:143470]: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. {ECO:0000269 PubMed:12091484, ECO:0000269 PubMed:2215607, ECO:0000269 PubMed:8408659}. Note=The disease is caused by mutations affecting the gene represented in this entry.

Genatlas disease for CETP Gene

elevated lipoprotein,high density (HDL) with coronary heart disease (Japanese-American men)

Relevant External Links for CETP

Genetic Association Database (GAD)
CETP
Human Genome Epidemiology (HuGE) Navigator
CETP
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CETP
genes like me logo Genes that share disorders with CETP: view

Publications for CETP Gene

  1. The effect of a novel intergenic polymorphism (rs11774572) on HDL-cholesterol concentrations depends on TaqIB polymorphism in the cholesterol ester transfer protein gene. (PMID: 19364639) Junyent M … Ordovas JM (Nutrition, metabolism, and cardiovascular diseases : NMCD 2010) 3 22 45 60
  2. Influence of menopause and cholesteryl ester transfer protein (CETP) TaqIB polymorphism on lipid profile and HDL subpopulations distribution in women with and without type 2 diabetes. (PMID: 20006332) Russo GT … Asztalos B (Atherosclerosis 2010) 3 22 45 60
  3. Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms. (PMID: 20026784) Sofat R … Casas JP (Circulation 2010) 3 22 45 60
  4. Cholesteryl ester transfer protein (CETP) genotype and reduced CETP levels associated with decreased prevalence of hypertension. (PMID: 20511482) Schechter CB … Atzmon G (Mayo Clinic proceedings 2010) 3 22 45 60
  5. Is dyslipidemia sustained during remission of nephrotic syndrome genetically determined? Evaluation of genetic polymorphisms of proteins involved in lipoprotein metabolism in children and adolescents with nephrotic syndrome. (PMID: 19341173) Ksiazek J … Grenda R (Polskie Archiwum Medycyny Wewnetrznej 2009) 3 22 45 60

Products for CETP Gene

Sources for CETP Gene

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