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Aliases & Descriptions for CETP
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc
, and/or 7Ensembl,
8miRBase) About This Section
|
| | | Descriptions |
|---|
| Lipid transfer protein I 3 | | cholesteryl ester transfer protein, plasma 2 | | lipid transfer protein 2 |
|
| | Search outside databases for aliases for CETP genePrevious GC identifers: GC16M047282 GC16P057046 GC16P056730 GC16P056771 |
Summaries for CETP(According to Entrez Gene,
Wikipedia's
Gene Wiki,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
| EntrezGene summary for CETP: Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters between lipoproteins. CETP may effect susceptibility to atherosclerosis. [provided by RefSeq] UniProtKB/Swiss-Prot: CETP_HUMAN, P11597Function: Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterolGene Wiki entry for CETP (Cholesterylester_transfer_protein) |
Genomic Location for CETP
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 36),
and/or miRBase,
Genomic Views according to
UCSC and
Ensembl,
Transcription factor binding sites according to
SABiosciences) About This Section
| Genomic View: UCSC Golden Path with GeneCards custom track
Transcription factor binding sites upstream to the CETP gene 
Entrez Gene cytogenetic band: 16q21 Ensembl cytogenetic band: 16q13 HGNC cytogenetic band: 16q13CETP Gene in genomic location: bands according to Ensembl, locations according to
(and/or Entrez Gene and/or Ensembl if different)
 GeneLoc gene densities for chromosome 16 GeneLoc Exon Structure GeneLoc location for GC16P055553:
(about GC identifiers)
Start:
|
55,553,263 bp from pter |
End:
|
55,575,257 bp from pter |
Size:
|
21,995 bases |
Orientation:
|
plus strand |
RefSeq DNA sequence:- NC_000016.8 NT_010498.15
| Proteins for CETP
(According to
1UniProtKB,
and/or Ensembl,
Phosphorylation sites according to 2Phosphosite,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Enzo Life Sciences,
Abnova,
OriGene and/or,
Abcam,
Biochemical Assays by
Invitrogen,
Millipore,
R&D Systems,
Cell Signaling Technology, and/or
Enzo Life Sciences,
Ontologies according to Gene
Ontology Consortium 01 Apr 2009 and
Entrez Gene,
Antibodies by Invitrogen,
Millipore,
Sigma-Aldrich,
R&D Systems,
Cell Signaling Technology,
Abcam,
Abnova, and/or
Novus Biologicals)
About This Section
| UniProtKB/Swiss-Prot: CETP_HUMAN, P11597 (See
protein sequence)Recommended Name: Cholesteryl ester transfer protein precursor Size: 493 amino acids; 54756 Da
Subcellular location: Secreted, extracellular space
PDB structures from and Proteopedia :2OBD (3D)
 
Secondary accessions: Q13987 Q13988Alternative splicing: 2 isoforms: P11597-1 P11597-2 REFSEQ proteins: NP_000069.2
ENSEMBL proteins: ENSP00000200676 ENSP00000369106
Human Recombinant Proteins               OriGene Purified Recombinant Human Protein: CETP 
4 Gene Ontology (GO) cellular component terms (links to tree view): About this table
Antibodies for CETP: Assays for CETP: | Protein
Domains/ Families for CETP(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
| - Graphical View of Domain Structure for InterPro Entry P11597
ProtoNet protein and cluster: P11597 1 Blocks protein family: IPB001124 Lipid-binding serum glycoprotein
UniProtKB/Swiss-Prot: CETP_HUMAN, P11597Similarity: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family | Gene Function for CETP
(According to MGI Jun 06 2009, UniProtKB,
IUBMB,and/or Genatlas,
shRNA from
OriGene,
Sigma-Aldrich, RNAi from
Sigma-Aldrich,
RNAi Products,
Clones, and
Q-PCR Products
from Invitrogen,
Millipore,
OriGene, and/or
Abnova,
siRNAs from
Applied Biosystems,
SYBR primers from OriGene,
Cell-based Assays from Millipore,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000078
Applied Biosystems Silencer® siRNAs for CETP
Sigma-Aldrich siRNA and siRNA Panels for CETP  Sigma-Aldrich shRNA Panels and shRNA for CETP  Explore Sigma-Aldrich super-pooled esiRNAs 
              OriGene GFP tagged cDNA clone in CMV expression vector: NM_000078                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000078                                  untagged cDNA clones in CMV expression vector (see all 2): NM_000078 
Primers: Browse
Quantitative PCR Central at Invitrogen for Q-PCR LUX™ Primers               OriGene genome-wide validated SYBR primer pairs: NM_000078
UniProtKB/Swiss-Prot: CETP_HUMAN, P11597Function: Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterolGenatlas biochemistry entry for CETP:cholesteryl ester transfer protein,plasma,with low homology to LBP expressed in and throughout differentiation of preadypocyte5 Gene Ontology (GO) molecular function terms (links to tree view): About this table | Pathways & Interactions for CETP
(Pathways according to Invitrogen
(maps by GeneGo),
Millipore,
Cell Signaling Technology,
Sigma-Aldrich,
KEGG
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Proteins Network according to
SABiosciences,
Interactions according to 1UniProtKB,
2MINT, and/or
3STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Apr 2009 via
Entrez Gene.)
About This Section
|
3 Sigma-Aldrich "Your Favorite Gene" Pathways for CETP (Your Favorite Gene powered by Ingenuity) 
Gene Network CentralTM Interacting Genes and Proteins Network for CETP 
5/26 Interacting proteins for CETP (ENSP000002006763) via UniProtKB, MINT, and/or STRING (see all 26
)About this table
5/13 Gene Ontology (GO) biological process terms (links to tree view) (see all 13
): About this table
|
Drugs & Compounds for CETP(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
Sigma-Aldrich, Tocris Bioscience, and/or
Novoseek and Drugs according to
Enzo Life Sciences and/or
PharmGKB)
About This Section
|
Browse Tocris compounds for CETP 10/22 Novoseek chemical compound relationships for CETP gene (see all 22
)
| Compound |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| torcetrapib |
95.30 |
163 |
18808319 (4), 19164467 (4), 16326978 (3), 18646836 (3) (see all 73) |
| cholesterol ester |
92.33 |
153 |
15064092 (4), 14608418 (3), 11887180 (2), 12708757 (2) (see all 99) |
| cholesterol |
89.03 |
1431 |
18178167 (9), 8847481 (8), 7857368 (7), 12772435 (7) (see all 99) |
| lipid |
83.77 |
871 |
16905138 (6), 10582542 (6), 7738519 (5), 8908157 (5) (see all 99) |
| phospholipid |
74.96 |
194 |
8071605 (5), 11013306 (4), 8673633 (3), 8908157 (3) (see all 93) |
| sele |
69.49 |
3 |
11341749 (1), 11714857 (1), 15076187 (1) |
| allergens |
65.18 |
42 |
10069888 (3), 15347375 (2), 12002744 (2), 12589356 (2) (see all 31) |
| cholesteryl oleate |
60.94 |
2 |
1854368 (1), 7744792 (1) |
| triacylglycerol |
58.40 |
29 |
8608156 (3), 12444911 (2), 2252916 (2), 16822236 (2) (see all 13) |
| cholesteryl linoleate |
53.18 |
1 |
8558089 (1) |
About this table
1 PharmGKB drug compound relationship for CETP gene
| Drug compound |
PharmGKB Relations |
PubMed IDs for articles supporting these relationships |
| pravastatin | PD   | 9420339 | About this table
|
Transcripts for CETP(GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 219 Homo sapiens; Jun 2 2009) or GenBank, RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
non coding RNAs according to
RNAdb,
ESTs according to GeneTide,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from Invitrogen,
Millipore, and/or
Abnova,
siRNAs from Applied Biosystems,
Sigma-Aldrich,
shRNA from
Sigma-Aldrich,
OriGene,
Tagged/untagged cDNA clones from
OriGene, Expression Assays from Applied Biosystems) About This Section
|               OriGene 29mer shRNA kit in GFP-retroviral vector: NM_000078
Sigma-Aldrich siRNA and siRNA Panels for CETP  Sigma-Aldrich shRNA Panels and shRNA for CETP  Explore Sigma-Aldrich super-pooled esiRNAs 
Applied Biosystems Silencer® siRNAs: NM_000078 REFSEQ mRNAs for CETP gene: NM_000078.2
Applied Biosystems TaqMan ® Gene Expression Assays: NM_000078               OriGene GFP tagged cDNA clone in CMV expression vector: NM_000078                                  Myc/DDK tagged cDNA clone in CMV expression vector: NM_000078                                  untagged cDNA clones in CMV expression vector (see all 2): NM_000078  Additional cDNA sequence: AK291586.1 AK297699.1 BC025739.1 BT020064.1 CR599646.1 CR622658.1 M30185.1 M83573.1 2 DOTS entries: DT.211078 DT.95088624 24/54 AceView cDNA sequences (see all 54
):AW196951 BI819550 NM_000078 BQ068239 M83573 M30185 BQ879525 CR622658 BC025739 CR599646 BI041061 AL552260 BI771118 BM919861 BX459929 BX345751 R89105 AL575608 BI834490 AW291164 BQ710590 BU581023 CD687574 AI089788
highest scoring ESTs for CETP:M30185 AA843190 AA999853 AI021886 AI089788 AI095029 AI628058 AI671147 AI964062 AL575608 Unigene Cluster for CETP: Cholesteryl ester transfer protein, plasma Hs.89538 [show with all ESTs]Unigene Representative Sequence: M30185
GeneLoc Exon Structure
2 Alternative Splicing Database (ASD) splice patterns (SP) for CETP
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3 | ^ | 4 | ^ | 5 | ^ | 6 | ^ | 7 | ^ | 8 | ^ | 9 | ^ | 10 | ^ | 11 | ^ | 12 | ^ | 13 | ^ | 14 | ^ | 15 | ^ | 16a | · | 16b | |
| SP1: | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |   | |
| SP2: | |   | |   | |   | |   | |   | |   | |   | |   | |   | - |   | |   | |   | |   | |   | |   | |   | |   | |   |
About this scheme
ECgene alternative splicing isoforms for CETP
2 Ensembl transcripts including schematic representations: ENST00000200676
ENST00000379780
|
Expression for CETP
(Experimental results according to
1GeneNote
and GNF BioGPS,
probe sets-to-genes annotations according to
2GeneAnnot ,
3GeneTide ,
Sets of similar genes according to GeneDecks,
Electronic Northern calculations according to data from
UniGene (Build 219 Homo sapiens),
SAGE tags according to
CGAP,
plus additional links to
SOURCE, and/or
GNF
BioGPS, and/or
EXPOLDB, and/or
UniProtKB,
Expression Assays from
Applied Biosystems
)
About This Section
| CETP expression in normal and diseased human tissues
Applied Biosystems TaqMan ® Gene Expression Assays for CETP
1 / 2 / 3 3 probe-sets matching CETP gene Data from
(Publications) and GNF BioGPS About these images About these images
CGAP SAGE TAG: --
SOURCE GeneReport for Unigene cluster: Hs.89538
Expression variation in blood from EXPOLDB for CETP UniProtKB/Swiss-Prot: CETP_HUMAN, P11597Tissue specificity: Expressed by the liver and secreted in plasma |
Orthologs for CETP
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
and/or
5MGI Jun 06 2009,
with possible further links to
Flybase
and/or
WormBase,
Gene Trees according to Ensembl)
About This Section
|
Orthologs for CETP gene from 3 species
About this table Species with no ortholog for CETP
ENSEMBL Gene Tree for CETP | Paralogs for CETP(Paralogs according to 1HomoloGene and 2Ensembl, Pseudogenes according to 3Pseudogene.org) About This Section
| -- |
SNPs/Variants for CETP(According to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE, and
UniProtKB,
Linkage Disequilibrium by HapMap,
Genotyping Reagents from
Applied Biosystems)
About This Section
|
HapMap Linkage Disequilibrium images for CETP (up to first 250kb)
|
Disorders & Mutations for CETP
(in which this Gene is Involved, According to
OMIM, UniProtKB,
Novoseek, PharmGKB,
Genatlas, GeneTests,
Blood group antigen gene mutations by BGMUT,
HGMD, GAD,
HuGE Navigator,
BCGD,
and/or TGDB.)
About This Section
|
OMIM: 118470 UniProtKB/Swiss-Prot: CETP_HUMAN, P11597
Defects in CETP are a cause of hyperalphalipoproteinemia [MIM:143470]. Affected individuals show high levels of alpha-lipoprotein (high density lipoprotein/HDL) Defects in CETP are the cause of CETP deficiency [MIM:607322]. This is an autosomal dominant condition associated with increased HDL cholesterol levels10/84 Novoseek disease relationships for CETP gene (see all 84
)
| Disease |
Score |
Articles |
PubMed IDs for Articles with Shared Sentences (# sentences) |
| cetp deficiency |
97.31 |
346 |
8911072 (6), 15256762 (6), 2215607 (6), 11020466 (6) (see all 99) |
| hyperalphalipoproteinemia |
92.26 |
53 |
11887180 (3), 8333866 (3), 11020466 (3), 8350515 (2) (see all 27) |
| atherosclerosis |
77.67 |
244 |
10195942 (4), 17272756 (4), 16946130 (4), 15256762 (3) (see all 99) |
| hypertriglyceridemia |
72.68 |
30 |
1752964 (3), 8376576 (3), 8977446 (2), 7989603 (2) (see all 18) |
| hypercholesterolemia familial |
71.98 |
36 |
7605391 (2), 1634194 (2), 15026427 (2), 7701533 (2) (see all 22) |
| dyslipidemia |
70.92 |
33 |
15842977 (2), 15529021 (2), 15185777 (1), 17700364 (1) (see all 24) |
| hypoalphalipoproteinemia |
69.67 |
6 |
7712672 (1), 9102177 (1), 7749855 (1), 7583547 (1) |
| coronary heart disease |
69.64 |
70 |
15377415 (2), 1975178 (2), 10861897 (2), 16098387 (2) (see all 42) |
| allergy food |
64.14 |
7 |
17489047 (2), 13679821 (1), 17496422 (1), 15672475 (1) (see all 6) |
| dyslipoproteinemia |
64.08 |
5 |
1858579 (1), 16087810 (1), 9543093 (1), 16961620 (1) |
About this table
1 PharmGKB disease relationship for CETP geneAbout this table
Genatlas disease: CETP elevated lipoprotein,high density (HDL) with coronary heart disease (Japanese-American men) Human Gene Mutation Database: CETP Genetic Association Database: CETP Human Genome Epidemiology Navigator: CETP (235 documents)
|
Medical News for CETP(Possibly Related Articles in
Doctor's Guide)
About This Section
| |
Publications for CETP (in
PubMed.
Associations of this gene to articles via
1Novoseek,
2HGNC,
3Entrez Gene,
4UniProtKB/Swiss-Prot,
5UniProtKB/TrEMBL,
6GAD, and/or
7PharmGKB)
About This Section
| 10/1192 PubMed articles for CETP gene (see all 1192
):- Organization of the human cholesteryl ester transfer protein gene. (PubMed id 2334701)1, 2, 3, 4 Agellon L.B....Tall A.R. (1990)
- Cloning and sequencing of human cholesteryl ester transfer protein cDNA. (PubMed id 3600759)2, 3, 4 Drayna D....Lawn R. (1987)
- Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation. (PubMed id 2215607)1, 3, 4 Inazu A.... Tall A.R. (1990)
- Haplotype analysis of the CETP gene: not TaqIB, but the closely linked -629C-->A polymorphism and a novel promoter variant are independently associated with CETP concentration. (PubMed id 12499392)1, 3, 6 Klerkx A.H.... Kuivenhoven J.A. (2003)
- A novel cholesteryl ester transfer protein promoter polymorphism (-971G/A) associated with plasma high-density lipoprotein cholesterol levels. Interaction with the TaqIB and -629C/A polymorphisms. (PubMed id 11888509)1, 3, 6 Le Goff W....Thillet J. (2002)
- Human cholesteryl ester transfer protein gene proximal promoter contains dietary cholesterol positive responsive elements and mediates expression in small intestine and periphery while predominant liver and spleen expression is controlled by 5'-distal sequences. Cis-acting sequences mapped in transgenic mice. (PubMed id 8943225)1, 3, 4 Oliveira C.F.O.... Tall A.R. (1996)
- Lack of relationship in long-term type 1 diabetic patients between diabetic nephropathy and polymorphisms in apolipoprotein epsilon, lipoprotein lipase and cholesteryl ester transfer protein. Genetique de la Nephropathie Diabetique Study Group. Donnees Epidemiologiques sur le Syndrome d'Insulino-Resistance Study Group. (PubMed id 11096142)1, 3, 6 Hadjadj S....Marre M. (2000)
- The association of common SNPs and haplotypes in the CETP and MDR1 genes with lipids response to fluvastatin in familial hypercholesterolemia. (PubMed id 16002074)1, 3, 6 Bercovich D....Meiner V. (2006)
- [Relationship between gene polymorphism at CETP locus and hyperlipidemia in the middle-aged and the elder] (PubMed id 15098490)1, 3, 6 Zhao Y....Li Y. (2004)
- A common mutation in cholesteryl ester transfer protein gene and plasma HDL cholesterol level before and after hormone replacement therapy in Korean postmenopausal women. (PubMed id 12164095)1, 3, 6 Choi H.S....Han I.K. (2002)
|
Search for CETP
(in PubMed,
OMIM, and NCBI Bookshelf) About This Section
|
|
Genome Databases showing CETP
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
and/or
H-InvDB)
About This Section
|
| Other Databases showing CETP
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CETP(According to ATLAS, HORDE, IMGT, MTDB, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL, Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot) About This Section
|
| Name | Description |
| SHMPD | http://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CETP | | Wikipedia | http://en.wikipedia.org/wiki/Cholesterylester_transfer_protein |
|
| | | About This Section
| --
| Services for CETP(Reagents available from Applied Biosystems, Antibodies and assays by Cell
Signaling Technology, Abcam, Novus Biologicals, Sigma-Aldrich, R&D Systems, Millipore, Abnova, and/or Invitrogen, Clones available from OriGene,and/or Invitrogen, Drugs and/or compounds by Sigma-Aldrich, Enzo Life Sciences, and/or Tocris Bioscience) About This Section
| 
 Products for CETP:

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