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CETP Gene

protein-coding   GIFtS: 61
GCID: GC16P056996

Cholesteryl Ester Transfer Protein, Plasma

  See CETP-related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Cholesteryl Ester Transfer Protein, Plasma1 2
BPI Fold Containing Family F1 2
Lipid Transfer Protein I2 3
HDLCQ102 5
BPIFF2
Cholesteryl Ester Transfer Protein2

External Ids:    HGNC: 18691   Entrez Gene: 10712   Ensembl: ENSG000000872377   OMIM: 1184705   UniProtKB: P115973   

Export aliases for CETP gene to outside databases

Previous GC identifers: GC16M047282 GC16P057046 GC16P056730 GC16P056771 GC16P055553 GC16P042865


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CETP Gene:
The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester
from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of
hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this
gene. (provided by RefSeq, Oct 2013)

GeneCards Summary for CETP Gene:
CETP (cholesteryl ester transfer protein, plasma) is a protein-coding gene. Diseases associated with CETP include hyperalphalipoproteinemia, and cetp-related hyperalphalipoproteinemia. GO annotations related to this gene include lipid binding and lipid transporter activity.

UniProtKB/Swiss-Prot: CETP_HUMAN, P11597
Function: Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol

Gene Wiki entry for CETP (Cholesterylester transfer protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NT_010498.16  NC_018927.2  
Regulatory elements:
   Regulatory transcription factor binding sites in the CETP gene promoter:
         p53   AP-1   MEF-2   ATF-2   MEF-2A   c-Rel   COMP1   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCETP promoter sequence
   Search Chromatin IP Primers for CETP

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CETP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q13   HGNC cytogenetic band: 16q13

CETP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CETP gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056996:  view genomic region     (about GC identifiers)

Start:
56,995,762 bp from pter      End:
57,017,757 bp from pter
Size:
21,996 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., eBioscience, and/or antibodies-online,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., eBioscience, and/or antibodies-online, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, antibodies-online, and/or others.)
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UniProtKB/Swiss-Prot: CETP_HUMAN, P11597 (See protein sequence)
Recommended Name: Cholesteryl ester transfer protein precursor  
Size: 493 amino acids; 54756 Da
3 PDB 3D structures from and Proteopedia for CETP:
2OBD (3D)        4EWS (3D)        4F2A (3D)    
Secondary accessions: Q13987 Q13988 Q53YZ1
Alternative splicing: 2 isoforms:  P11597-1   P11597-2   

Explore the universe of human proteins at neXtProt for CETP: NX_P11597

Explore proteomics data for CETP at MOPED

Post-translational modifications: 

  • Glycosylation2 at Asn105, Asn257, Asn358, Asn413

  • See CETP Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_000069.2  NP_001273014.1  

    ENSEMBL proteins: 
     ENSP00000200676   ENSP00000369106   ENSP00000456276  
    Reactome Protein details: P11597

    CETP Human Recombinant Protein Products:

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    Novus Biologicals CETP Protein
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    Cloud-Clone Corp. Proteins for CETP

     
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    antibodies-online proteins for CETP (17 products) 

     
    antibodies-online peptides for CETP

    CETP Antibody Products:

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    antibodies-online antibodies for CETP (50 products) 

    CETP Assay Products:

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    Cloud-Clone Corp. ELISAs for CETP
    Cloud-Clone Corp. CLIAs for CETP
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    antibodies-online kits for CETP (33 products) 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    BPIF: BPI fold containing

    5 InterPro protein domains:
     IPR017942 Lipid-bd_serum_glycop_N
     IPR017943 Bactericidal_perm-incr_a/b_dom
     IPR017130 Cholesteryl_ester_transfer
     IPR001124 Lipid-bd_serum_glycop_C
     IPR017954 Lipid-bd_serum_glycop_CS

    Graphical View of Domain Structure for InterPro Entry P11597

    ProtoNet protein and cluster: P11597

    1 Blocks protein domain: IPB001124 Lipid-binding serum glycoprotein

    UniProtKB/Swiss-Prot: CETP_HUMAN, P11597
    Similarity: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family


    Find genes that share domains with CETP           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CETP_HUMAN, P11597
    Function: Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol

         Genatlas biochemistry entry for CETP:
    cholesteryl ester transfer protein,plasma,with low homology to LBP expressed in and throughout differentiation of
    preadypocyte

         Gene Ontology (GO): Selected molecular function terms (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005319lipid transporter activity IDA2833496
    GO:0005548phospholipid transporter activity IDA2833496
    GO:0008289lipid binding IDA3818596
    GO:0015485cholesterol binding IDA2833496
    GO:0017127cholesterol transporter activity IDA2833496
         
    Find genes that share ontologies with CETP           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CETP
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    Inhib. RNA
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    Gene Editing
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    GenScript: all cDNA clones in your preferred vector: CETP (NM_000078)
    Sino Biological Human cDNA Clone for CETP
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CETP
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CETP

    Cell Line
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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CETP_HUMAN, P11597: Secreted, extracellular space
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    extracellular5
    lysosome1
    nucleus1

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA3104518
    GO:0031982vesicle IDA2833496
    GO:0034364high-density lipoprotein particle IDA3104518
    GO:0070062extracellular vesicular exosome IDA19056867

    Find genes that share ontologies with CETP           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CETP About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Lipoprotein metabolism
    Lipoprotein metabolism0.59
    HDL-mediated lipid transport0.00
    Lipid digestion, mobilization, and transport0.59
    LDL-mediated lipid transport0.00
    2Metabolism
    Metabolism0.38
    Metabolism of lipids and lipoproteins0.37
    3Statin Pathway
    Statin Pathway0.73
    4COPI Mediated Transport
    Cholesterol and Sphingolipids transport Transport from Golgi and ER to the apical membrane normal and CF 0.31
    5Selected targets of C EBPbeta
    Selected targets of C EBPbeta


    Find genes that share SuperPaths with CETP           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    1 GeneGo (Thomson Reuters) Pathway for CETP
        Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)

    1 BioSystems Pathway for CETP
        Statin Pathway


    2 Reactome Pathways for CETP
        HDL-mediated lipid transport
    LDL-mediated lipid transport


        Pathway & Disease-focused RT2 Profiler PCR Array including CETP: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CETP

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    Selected Interacting proteins for CETP (P115973 ENSP000002006764) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LPLP068583, ENSP000003097574I2D: score=2 STRING: ENSP00000309757
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    ARPC3O151453I2D: score=3 
    APOBENSP000002332424STRING: ENSP00000233242
    About this table

    Gene Ontology (GO): Selected biological process terms (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006641triglyceride metabolic process IDA2833496
    GO:0006869lipid transport IDA3818596
    GO:0006898receptor-mediated endocytosis TAS--
    GO:0008203cholesterol metabolic process IMP2586614
    GO:0010745negative regulation of macrophage derived foam cell differentiation IC16670775

    Find genes that share ontologies with CETP           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Compounds for CETP available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SC 26196Selective delta6 desaturase inhibitor[218136-59-5]
    PF 429242Competitive inhibitor of SREBP site 1 protease[947303-87-9]
    R 59-022Diacylglycerol kinase inhibitor; increases PKC activity[93076-89-2]
    SKI IISelective non-lipid inhibitor of sphingosine kinase[312636-16-1]
    (+-)-Octanoylcarnitine chlorideIntermediate in lipid metabolism[18822-86-1]

    Selected Novoseek inferred chemical compound relationships for CETP gene (see all 77)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    torcetrapib 95.9 220 20026784 (6), 19522058 (5), 18808319 (4), 19164467 (4) (see all 91)
    cholesterol ester 92.8 171 15064092 (4), 14608418 (3), 11887180 (2), 8344921 (2) (see all 99)
    cholesterol 89.2 1527 18178167 (9), 8847481 (8), 7857368 (7), 12772435 (7) (see all 99)
    lipid 84.2 957 16905138 (6), 10582542 (6), 7738519 (5), 8908157 (5) (see all 99)
    phospholipid 74.8 207 8071605 (5), 11013306 (4), 8673633 (3), 8908157 (3) (see all 98)
    atorvastatin 70.2 42 17868678 (3), 10634817 (3), 12663600 (3), 16541186 (2) (see all 21)
    probucol 68.2 71 8509722 (6), 1903061 (5), 14642415 (4), 8447724 (4) (see all 21)
    sele 67.6 3 11341749 (1), 11714857 (1), 15076187 (1)
    niacin 67.5 31 18669886 (5), 19825813 (2), 17335774 (2), 16455013 (1) (see all 14)
    allergens 66.2 45 10069888 (3), 15347375 (2), 12002744 (2), 12589356 (2) (see all 33)

    6 PharmGKB related drug/compound annotations for CETP gene    About this table
    Drug/compound PharmGKB Annotation
    atorvastatinCA  
    fluvastatinCA  
    hmg coa reductase inhibitorsCA  
    lovastatinCA  
    pravastatinCA  
    simvastatinCA  



    Find genes that share compounds with CETP           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CETP gene (2 alternative transcripts): 
    NM_000078.2  NM_001286085.1  

    Unigene Cluster for CETP:

    Cholesteryl ester transfer protein, plasma
    Hs.89538  [show with all ESTs]
    Unigene Representative Sequence: M30185
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000200676(uc002eki.2) ENST00000379780(uc002ekj.2) ENST00000569082
    ENST00000566128
    miRNA
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    Additional mRNA sequence: 

    AK291586.1 AK297699.1 BC025739.1 BT020064.1 M30185.1 M83573.1 

    2 DOTS entries:

    DT.211078  DT.95088624 

    Selected AceView cDNA sequences (see all 54):

    BI041061 BI771118 M83573 CR599646 AL552260 M30185 NM_000078 BM919861 
    AW196951 BQ879525 BQ068239 BC025739 BI819550 CR622658 BU753737 AA999853 
    R89105 BV183769 AI964062 BM007900 BM694301 BI766164 BU580567 BX459929 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CETP    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                                                                                                            
    SP2:                                                        -                                                   


    ECgene alternative splicing isoforms for CETP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CETP expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CETP Expression
    About this image


    CETP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     
     Endothelium (Cardiovascular System)
             Endothelial-like cells
    CETP Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CETP Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.89538

    UniProtKB/Swiss-Prot: CETP_HUMAN, P11597
    Tissue specificity: Expressed by the liver and secreted in plasma

        Pathway & Disease-focused RT2 Profiler PCR Array including CETP: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

    Primer
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    OriGene qPCR primer pairs and template standards for CETP
    OriGene qSTAR qPCR primer pairs in human, mouse for CETP
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    QuantiFast Probe-based Assays in human, mouse, rat CETP
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CETP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

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    This gene was present in the common ancestor of chordates.

    Orthologs for CETP gene from Selected species (see all 7)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia CETP6
    cholesteryl ester transfer protein, plasma
    60(a)
    1 ↔ 1
    1(447942630-447970229)
    chicken
    (Gallus gallus)
    Aves CETP1 cholesteryl ester transfer protein, plasma 60.88(n)
    53.31(a)
      415645  NM_001034814.1  NP_001029986.1 
    lizard
    (Anolis carolinensis)
    Reptilia CETP6
    cholesteryl ester transfer protein, plasma
    48(a)
    1 ↔ 1
    GL344281.1(22178-49548)
    tropical clawed frog
    (Xenopus tropicalis)
    Amphibia cetp1 cholesteryl ester transfer protein, plasma 60.62(n)
    58.42(a)
      100494610  XM_002937170.2  XP_002937216.2 
    zebrafish
    (Danio rerio)
    Actinopterygii cetp1 cholesteryl ester transfer protein, plasma 54.07(n)
    46.15(a)
      492488  NM_001007360.1  NP_001007361.1 


    ENSEMBL Gene Tree for CETP (if available)
    TreeFam Gene Tree for CETP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section

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      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Polymorphic Variants from UniProtKB/Swiss-Prot
    CETP_HUMAN, P11597: Genetic variations in CETP define the high density lipoprotein cholesterol level quantitative trait
    locus 10 (HDLCQ10) [MIM:143470]


    Selected SNPs for CETP (see all 801)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs23037901,2,,4
    C,F,HHyperalphalipoproteinemia 1 (HALP1)4 pathogenic158030187(+) CTTCGA/GCATCA 2 D G mis113Minor allele frequency- G:0.01EA NS NA EU 8377
    VAR_0331004
    Hyperalphalipoproteinemia 1 (HALP1)4--see VAR_0331002 R C mis40--------
    VAR_0330994
    Hyperalphalipoproteinemia 1 (HALP1)4--see VAR_0330992 L P mis40--------
    rs1421174891,2
    Cuntested158008881(+) GGCATC/TGTGTG 2 I syn11Minor allele frequency- T:0.00NA 4552
    rs58821,2,,4
    C,F,O,A,Hother158028987(+) AGTCCA/GTCCAG 2 I V mis137Minor allele frequency- G:0.43MN NS NA EA WA EU 11639
    rs284194041,2
    C--42863290(+) AGGGAA/GGGGAG 1 -- us2k1 tfbs3 trp33Minor allele frequency- G:0.00NA WA CSA 5
    rs767641591,2
    C--56994393(+) TATTTG/TGTTTT 1 -- us2k10--------
    rs616310851,2
    C--56994395(+) TTTGG-/T/TT  
            
    TTTTT
    1 -- us2k11NA 2
    rs784308031,2
    C--56994395(+) TTTGGG/TTTTTT 1 -- us2k10--------
    rs58170821,2
    C--56997349(+) ATCTC-/AAACAA 1 -- int14Minor allele frequency- A:0.40NS CSA 224

    HapMap Linkage Disequilibrium report for CETP (56995762 - 57017757 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CETP:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv524073CNV Loss19592680
    nsv527160CNV Gain19592680

    Human Gene Mutation Database (HGMD): CETP
    Site Specific Mutation Identification with PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CETP
    DNA2.0 Custom Variant and Variant Library Synthesis for CETP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section

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    OMIM gene information: 118470   
    OMIM disorders: 143470  
    UniProtKB/Swiss-Prot: CETP_HUMAN, P11597
  • Hyperalphalipoproteinemia 1 (HALP1) [MIM:143470]: A condition characterized by high levels of high
    density lipoprotein (HDL) and increased HDL cholesterol levels. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • Selected diseases for CETP (see all 21):    
    About MalaCards
    hyperalphalipoproteinemia    cetp-related hyperalphalipoproteinemia    hyperlipoproteinemia type iii    coronary stenosis
    food allergy    benign recurrent intrahepatic cholestasis    aortic atherosclerosis    hypoalphalipoproteinemia
    carotid intimal medial thickness    coronary restenosis    familial hyperlipidemia    gallbladder disease
    tangier disease    familial hypercholesterolemia    hypercholesterolemia    vascular disease
    hypertriglyceridemia    coronary artery disease    atherosclerosis    alzheimer's disease

    5 diseases from the University of Copenhagen DISEASES database for CETP:
    Atherosclerosis     Coronary heart disease     Diabetes mellitus     Familial hyperlipidemia
    Myocardial infarction

    Find genes that share disorders with CETP           About GenesLikeMe

    Selected Novoseek inferred disease relationships for CETP gene (see all 86)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cetp deficiency 97.3 366 8911072 (6), 15256762 (6), 2215607 (6), 11020466 (6) (see all 99)
    hyperalphalipoproteinemia 92.6 58 11887180 (3), 8333866 (3), 11020466 (3), 8350515 (2) (see all 29)
    atherosclerosis 78.1 272 10195942 (4), 17272756 (4), 16946130 (4), 15256762 (3) (see all 99)
    hypertriglyceridemia 74.6 34 1752964 (3), 8376576 (3), 8977446 (2), 7989603 (2) (see all 21)
    dyslipidemia 71.8 41 15842977 (2), 15529021 (2), 15185777 (1), 17700364 (1) (see all 28)
    hypercholesterolemia familial 71.3 36 7605391 (2), 1634194 (2), 15026427 (2), 7701533 (2) (see all 22)
    coronary heart disease 70 74 15377415 (2), 1975178 (2), 10861897 (2), 16098387 (2) (see all 45)
    hypoalphalipoproteinemia 68.8 6 7712672 (1), 9102177 (1), 7749855 (1), 7583547 (1)
    allergy food 65 11 17489047 (2), 13679821 (1), 17496422 (1), 15672475 (1) (see all 10)
    hypercholesterolemia 63.9 42 10192749 (3), 7749806 (2), 9246022 (2), 12444911 (2) (see all 29)

    Genatlas disease: CETP
    elevated lipoprotein,high density (HDL) with coronary heart disease (Japanese-American men)

    Genetic Association Database (GAD): CETP
    Human Genome Epidemiology (HuGE) Navigator: CETP (323 documents)

    Export disorders for CETP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CETP gene, integrated from 10 sources (see all 1483):
    (articles sorted by number of sources associating them with CETP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Organization of the human cholesteryl ester transfer protein gene. (PubMed id 2334701)1, 2, 3, 9 Agellon L.B....Tall A.R. (Biochemistry 1990)
    2. Two novel missense mutations in the CETP gene in Japanese hyperalphalipoproteinemic subjects: high-throughput assay by Invader assay. (PubMed id 12091484)1, 2, 4 Nagano M.... Matsuzawa Y. (J. Lipid Res. 2002)
    3. Cloning and sequencing of human cholesteryl ester transfer protein cDNA. (PubMed id 3600759)1, 2, 3 Drayna D....Lawn R. (Nature 1987)
    4. Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms. (PubMed id 20026784)1, 4, 9 Sofat R....Casas J.P. (Circulation 2010)
    5. Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation. (PubMed id 2215607)1, 2, 9 Inazu A.... Tall A.R. (N. Engl. J. Med. 1990)
    6. Cholesteryl ester transfer protein (CETP) genotype and reduced CETP levels associated with decreased prevalence of hypertension. (PubMed id 20511482)1, 4, 9 Schechter C.B....Atzmon G. (Mayo Clin. Proc. 2010)
    7. Cholesteryl ester transfer protein gene haplotypes, plasma high-density lipoprotein levels and the risk of coronary heart disease. (PubMed id 17287950)1, 4, 9 McCaskie P.A....Palmer L.J. (Hum. Genet. 2007)
    8. Prevalence and phenotypic spectrum of cholesteryl ester transfer protein gene mutations in Japanese hyperalphalipoproteinemia. (PubMed id 12482565)1, 4, 9 Maruyama T....Matsuzawa Y. (Atherosclerosis 2003)
    9. Taq1B polymorphism of cholesteryl ester transfer protein (CETP) gene in primary combined hyperlipidaemia. (PubMed id 19491422)1, 4, 9 Hassanzadeh T....Paoli M. (Indian J. Med. Res. 2009)
    10. Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. (PubMed id 18560005)1, 4, 9 Thompson A....Danesh J. (JAMA 2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section

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    Entrez Gene: 1071 HGNC: 1869 AceView: CETP Ensembl:ENSG00000087237 euGenes: HUgn1071
    ECgene: CETP H-InvDB: CETP

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CETP Pharmacogenomics, SNPs, Pathways
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CETP
    Wikipedia http://en.wikipedia.org/wiki/Cholesterylester_transfer_protein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CETP gene:
    Search GeneIP for patents involving CETP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, antibodies-online, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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