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Aliases for CETP Gene

Aliases for CETP Gene

  • Cholesteryl Ester Transfer Protein, Plasma 2 3
  • BPI Fold Containing Family F 2 3
  • Lipid Transfer Protein I 3 4
  • HDLCQ10 3 6
  • Cholesteryl Ester Transfer Protein 3
  • BPIFF 3

External Ids for CETP Gene

Previous GeneCards Identifiers for CETP Gene

  • GC16M047282
  • GC16P057046
  • GC16P056730
  • GC16P056771
  • GC16P055553
  • GC16P042865

Summaries for CETP Gene

Entrez Gene Summary for CETP Gene

  • The protein encoded by this gene is found in plasma, where it is involved in the transfer of cholesteryl ester from high density lipoprotein (HDL) to other lipoproteins. Defects in this gene are a cause of hyperalphalipoproteinemia 1 (HALP1). Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Oct 2013]

GeneCards Summary for CETP Gene

CETP (Cholesteryl Ester Transfer Protein, Plasma) is a Protein Coding gene. Diseases associated with CETP include hyperalphalipoproteinemia and cetp-related hyperalphalipoproteinemia. Among its related pathways are Metabolism and Metabolism. GO annotations related to this gene include lipid binding and lipid transporter activity.

UniProtKB/Swiss-Prot for CETP Gene

  • Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796).

Tocris Summary for CETP Gene

Gene Wiki entry for CETP Gene

No data available for PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CETP Gene

Genomics for CETP Gene

Regulatory Elements for CETP Gene

Genomic Location for CETP Gene

Start:
56,961,850 bp from pter
End:
56,983,845 bp from pter
Size:
21,996 bases
Orientation:
Plus strand

Genomic View for CETP Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CETP Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CETP Gene

Proteins for CETP Gene

  • Protein details for CETP Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P11597-CETP_HUMAN
    Recommended name:
    Cholesteryl ester transfer protein
    Protein Accession:
    P11597
    Secondary Accessions:
    • Q13987
    • Q13988
    • Q53YZ1

    Protein attributes for CETP Gene

    Size:
    493 amino acids
    Molecular mass:
    54756 Da
    Quaternary structure:
    No Data Available

    Three dimensional structures from OCA and Proteopedia for CETP Gene

    Alternative splice isoforms for CETP Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CETP Gene

Proteomics data for CETP Gene at MOPED

Post-translational modifications for CETP Gene

  • Glycosylation at Asn105, Asn257, Asn358, and Asn413
  • Modification sites at PhosphoSitePlus

Other Protein References for CETP Gene

ENSEMBL proteins:
Reactome Protein details:
REFSEQ proteins:

No data available for DME Specific Peptides for CETP Gene

Domains for CETP Gene

Gene Families for CETP Gene

HGNC:
  • BPIF :BPI fold containing

Graphical View of Domain Structure for InterPro Entry

P11597

UniProtKB/Swiss-Prot:

CETP_HUMAN :
  • P11597
Family:
  • Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.
genes like me logo Genes that share domains with CETP: view

Function for CETP Gene

Molecular function for CETP Gene

GENATLAS Biochemistry: cholesteryl ester transfer protein,plasma,with low homology to LBP expressed in and throughout differentiation of preadypocyte
UniProtKB/Swiss-Prot Function: Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL (PubMed:3600759, PubMed:24293641). Regulates the reverse cholesterol transport, by which excess cholesterol is removed from peripheral tissues and returned to the liver for elimination (PubMed:17237796).

Gene Ontology (GO) - Molecular Function for CETP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005319 lipid transporter activity IDA 2833496
GO:0005548 phospholipid transporter activity IDA 2833496
GO:0008289 lipid binding IDA 3818596
GO:0015485 cholesterol binding IDA 2833496
GO:0017127 cholesterol transporter activity IDA 24293641
genes like me logo Genes that share ontologies with CETP: view

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , miRNA , Transcription Factor Targeting and HOMER Transcription for CETP Gene

Localization for CETP Gene

Subcellular locations from UniProtKB/Swiss-Prot for CETP Gene

Secreted, extracellular space. Note=Secreted in plasma. {ECO:0000250 UniProtKB:P47896}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CETP Gene COMPARTMENTS Subcellular localization image for CETP gene
Compartment Confidence
extracellular 5
lysosome 1
nucleus 1

Gene Ontology (GO) - Cellular Components for CETP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region TAS --
GO:0005615 extracellular space IDA 24293641
GO:0031982 vesicle IDA 2833496
GO:0034364 high-density lipoprotein particle IDA 3104518
GO:0070062 extracellular exosome IDA 19056867
genes like me logo Genes that share ontologies with CETP: view

Pathways for CETP Gene

genes like me logo Genes that share pathways with CETP: view

Gene Ontology (GO) - Biological Process for CETP Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006641 triglyceride metabolic process IDA 2833496
GO:0006869 lipid transport IDA 3818596
GO:0006898 receptor-mediated endocytosis TAS --
GO:0008203 cholesterol metabolic process IMP 2586614
GO:0010745 negative regulation of macrophage derived foam cell differentiation IC 16670775
genes like me logo Genes that share ontologies with CETP: view

Compounds for CETP Gene

(5) Tocris Compounds for CETP Gene

Compound Action Cas Number
(�)-Hexanoylcarnitine chloride Intermediate in lipid metabolism [6920-35-0]
(�)-Octanoylcarnitine chloride Intermediate in lipid metabolism [18822-86-1]
Arachidonic acid (in Tocrisolve�100) Endogenous free fatty acid (in water-soluble emulsion) [506-32-1]
PF 429242 Competitive inhibitor of SREBP site 1 protease [947303-87-9]
R 59-022 Diacylglycerol kinase inhibitor; increases PKC activity [93076-89-2]

(77) Novoseek inferred chemical compound relationships for CETP Gene

Compound -log(P) Hits PubMed IDs
torcetrapib 95.9 149
cholesterol ester 92.8 113
cholesterol 89.2 346
lipid 84.2 249
phospholipid 74.8 125

(6) PharmGKB related drug/compound annotations for CETP Gene

genes like me logo Genes that share compounds with CETP: view

Transcripts for CETP Gene

Unigene Clusters for CETP Gene

Cholesteryl ester transfer protein, plasma:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CETP Gene

ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
SP1:
SP2: -

Relevant External Links for CETP Gene

GeneLoc Exon Structure for
CETP
ECgene alternative splicing isoforms for
CETP

Expression for CETP Gene

mRNA expression in normal human tissues for CETP Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CETP Gene

This gene is overexpressed in Spleen (16.8) and Adipose - Visceral (Omentum) (6.8).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CETP Gene

SOURCE GeneReport for Unigene cluster for CETP Gene Hs.89538

mRNA Expression by UniProt/SwissProt for CETP Gene

P11597-CETP_HUMAN
Tissue specificity: Expressed by the liver and secreted in plasma
genes like me logo Genes that share expressions with CETP: view

Orthologs for CETP Gene

This gene was present in the common ancestor of chordates.

Orthologs for CETP Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CETP 35
  • 99.26 (n)
  • 98.77 (a)
CETP 36
  • 99 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CETP 36
  • 60 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CETP 36
  • 56 (a)
OneToOne
chicken
(Gallus gallus)
Aves CETP 35
  • 60.88 (n)
  • 53.31 (a)
CETP 36
  • 50 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CETP 36
  • 48 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cetp 35
  • 60.62 (n)
  • 58.42 (a)
zebrafish
(Danio rerio)
Actinopterygii cetp 35
  • 54.07 (n)
  • 46.15 (a)
cetp 36
  • 42 (a)
OneToOne
Species with no ortholog for CETP:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • cow (Bos Taurus)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • mouse (Mus musculus)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CETP Gene

ENSEMBL:
Gene Tree for CETP (if available)
TreeFam:
Gene Tree for CETP (if available)

Paralogs for CETP Gene

No data available for Paralogs for CETP Gene

Variants for CETP Gene

Polymorphic Variants from UniProtKB/Swiss-Prot for CETP Gene

P11597-CETP_HUMAN
Genetic variations in CETP define the high density lipoprotein cholesterol level quantitative trait locus 10 (HDLCQ10) [MIM:143470]

Sequence variations from dbSNP and Humsavar for CETP Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs5880 - 56,981,179(+) TCCAG(C/G)CCTCC missense, reference
rs5881 - 56,978,100(+) TCGGC(A/G)GCTTC missense, reference
rs5882 other, - 56,982,180(+) AGTCC(A/G)TCCAG missense, reference
rs5883 -- 56,973,441(+) GTCTT(C/T)CACTC reference, synonymous-codon, intron-variant
rs5884 -- 56,962,045(+) GGCAC(A/C)TCGCA synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for CETP Gene

Variant ID Type Subtype PubMed ID
nsv524073 CNV Loss 19592680
nsv527160 CNV Gain 19592680

Relevant External Links for CETP Gene

HapMap Linkage Disequilibrium report
CETP
Human Gene Mutation Database (HGMD)
CETP

Disorders for CETP Gene

(1) OMIM Diseases for CETP Gene (118470)

UniProtKB/Swiss-Prot

CETP_HUMAN
  • Hyperalphalipoproteinemia 1 (HALP1) [MIM:143470]: A condition characterized by high levels of high density lipoprotein (HDL) and increased HDL cholesterol levels. {ECO:0000269 PubMed:12091484, ECO:0000269 PubMed:2215607, ECO:0000269 PubMed:8408659}. Note=The disease is caused by mutations affecting the gene represented in this entry.

(86) Novoseek inferred disease relationships for CETP Gene

Disease -log(P) Hits PubMed IDs
cetp deficiency 97.3 222
hyperalphalipoproteinemia 92.6 42
atherosclerosis 78.1 151
hypertriglyceridemia 74.6 28
dyslipidemia 71.8 30

Genatlas disease for CETP Gene

elevated lipoprotein,high density (HDL) with coronary heart disease (Japanese-American men)

Relevant External Links for CETP

Genetic Association Database (GAD)
CETP
Human Genome Epidemiology (HuGE) Navigator
CETP
genes like me logo Genes that share disorders with CETP: view

Publications for CETP Gene

  1. Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation. (PMID: 2215607) Inazu A. … Tall A.R. (N. Engl. J. Med. 1990) 3 4 23
  2. A missense mutation in the cholesteryl ester transfer protein gene with possible dominant effects on plasma high density lipoproteins. (PMID: 8408659) Takahashi K. … Tall A. (J. Clin. Invest. 1993) 3 4 23
  3. Human cholesteryl ester transfer protein gene proximal promoter contains dietary cholesterol positive responsive elements and mediates expression in small intestine and periphery while predominant liver and spleen expression is controlled by 5'-distal sequences. Cis-acting sequences mapped in transgenic mice. (PMID: 8943225) Oliveira C.F.O. … Tall A.R. (J. Biol. Chem. 1996) 3 4 23
  4. Common cholesteryl ester transfer protein mutations, decreased HDL cholesterol, and possible decreased risk of ischemic heart disease: The Copenhagen City Heart Study. (PMID: 11056092) Agerholm-Larsen B. … Nordestgaard B.G. (Circulation 2000) 3 23 48
  5. Lack of relationship in long-term type 1 diabetic patients between diabetic nephropathy and polymorphisms in apolipoprotein epsilon, lipoprotein lipase and cholesteryl ester transfer protein. GenActique de la Nephropathie DiabActique Study Group. DonnAces EpidAcmiologiques sur le Syndrome d'Insulino-RAcsistance Study Group. (PMID: 11096142) Hadjadj S. … Marre M. (Nephrol. Dial. Transplant. 2000) 3 23 48

Products for CETP Gene

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Lipoprotein Signaling & Cholesterol Metabolism in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CETP
    • QuantiTect SYBR Green Assays in human,mouse,rat
    • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
    • QuantiFast Probe-based Assays in human,mouse,rat
    • Predesigned siRNA for gene silencing in human,mouse,rat for CETP
    • Block miRNA regulation of CETP using miScript Target Protectors

    Sources for CETP Gene

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