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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CETP Gene

protein-coding   GIFtS: 61
GCID: GC16P056996

Cholesteryl Ester Transfer Protein, Plasma

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(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Cholesteryl Ester Transfer Protein, Plasma1 2
BPI Fold Containing Family F1 2
Lipid Transfer Protein I2 3
HDLCQ102 5
BPIFF2
Cholesteryl Ester Transfer Protein2

External Ids:    HGNC: 18691   Entrez Gene: 10712   Ensembl: ENSG000000872377   OMIM: 1184705   UniProtKB: P115973   

Export aliases for CETP gene to outside databases

Previous GC identifers: GC16M047282 GC16P057046 GC16P056730 GC16P056771 GC16P055553 GC16P042865


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CETP Gene:
Cholesteryl ester transfer protein (CETP) transfers cholesteryl esters between lipoproteins. CETP may effect
susceptibility to atherosclerosis. (provided by RefSeq, Jul 2008)

GeneCards Summary for CETP Gene: 
CETP (cholesteryl ester transfer protein, plasma) is a protein-coding gene. Diseases associated with CETP include hyperalphalipoproteinemia, and cetp deficiency, and among its related super-pathways are Lipoprotein metabolism and Metabolic pathways. GO annotations related to this gene include lipid binding and lipid transporter activity.

UniProtKB/Swiss-Prot: CETP_HUMAN, P11597
Function: Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol

Gene Wiki entry for CETP (Cholesterylester transfer protein) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CETP gene promoter:
         p53   AP-1   MEF-2   ATF-2   MEF-2A   c-Rel   COMP1   c-Jun   Pax-4a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCETP promoter sequence
   Search SABiosciences Chromatin IP Primers for CETP

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CETP


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q21   Ensembl cytogenetic band:  16q13   HGNC cytogenetic band: 16q13

CETP Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CETP gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P056996:  view genomic region     (about GC identifiers)

Start:
56,995,762 bp from pter      End:
57,017,757 bp from pter
Size:
21,996 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: CETP_HUMAN, P11597 (See protein sequence)
Recommended Name: Cholesteryl ester transfer protein precursor  
Size: 493 amino acids; 54756 Da
Subcellular location: Secreted, extracellular space
3 PDB 3D structures from and Proteopedia for CETP:
2OBD (3D)        4EWS (3D)        4F2A (3D)    
Secondary accessions: Q13987 Q13988 Q53YZ1
Alternative splicing: 2 isoforms:  P11597-1   P11597-2   

Explore the universe of human proteins at neXtProt for CETP: NX_P11597

Explore proteomics data for CETP at MOPED 

Post-translational modifications:

  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_P11597

  • CETP Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CETP Protein Expression
    REFSEQ proteins: NP_000069.2  
    ENSEMBL proteins: 
     ENSP00000200676   ENSP00000369106   ENSP00000456276  
    Reactome Protein details: P11597
    Human Recombinant Protein Products for CETP: 
    Browse Purified and Recombinant Proteins at EMD Millipore
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    Novus Biologicals CETP Protein
    Novus Biologicals CETP Lysate
    Browse Sino Biological Recombinant Proteins
    Browse Sino Biological Cell Lysates 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CETP 

    Gene Ontology (GO): 4 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region TAS--
    GO:0005615extracellular space IDA3104518
    GO:0031982vesicle IDA2833496
    GO:0034364high-density lipoprotein particle IDA3104518

    CETP for ontologies           About GeneDecksing



    CETP Antibody Products: 
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    LSBio Antibodies in human, mouse, rat for CETP 

    Assay Products for CETP: 
    Browse Kits and Assays available from EMD Millipore
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    GenScript Custom Assay Services for CETP
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CETP 
    Cloud-Clone Corp. CLIAs for CETP


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    BPIF: BPI fold containing

    5 InterPro protein domains:
     IPR017942 Lipid-bd_serum_glycop_N
     IPR017943 Bactericidal_perm-incr_a/b_dom
     IPR017130 Cholesteryl_ester_transfer
     IPR001124 Lipid-bd_serum_glycop_C
     IPR017954 Lipid-bd_serum_glycop_CS

    Graphical View of Domain Structure for InterPro Entry P11597

    ProtoNet protein and cluster: P11597

    1 Blocks protein domain: IPB001124 Lipid-binding serum glycoprotein

    UniProtKB/Swiss-Prot: CETP_HUMAN, P11597
    Similarity: Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family


    CETP for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CETP_HUMAN, P11597
    Function: Involved in the transfer of insoluble cholesteryl esters in the reverse transport of cholesterol

         Genatlas biochemistry entry for CETP:
    cholesteryl ester transfer protein,plasma,with low homology to LBP expressed in and throughout differentiation of
    preadypocyte

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005319lipid transporter activity IDA2833496
    GO:0005548phospholipid transporter activity IDA2833496
    GO:0008289lipid binding IDA3818596
    GO:0015485cholesterol binding IDA2833496
    GO:0017127cholesterol transporter activity IDA2833496
         
    CETP for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CETP 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CETP 
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    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CETP


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CETP About   (see all 7)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Lipoprotein metabolism
    Lipoprotein metabolism0.57
    Lipid digestion, mobilization, and transport0.56
    HDL-mediated lipid transport0.57
    2Metabolism
    Metabolism0.40
    Metabolism of lipids and lipoproteins0.34
    3Statin Pathway, Pharmacodynamics
    Statin Pathway0.73
    4Golgi to ER Retrograde Transport
    Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)0.31
    5Selected targets of C/EBPbeta
    Selected targets of C/EBPbeta

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways

    2 EMD Millipore Pathways for CETP
        Selected targets of C/EBPbeta
    Selected targets of C/EBPalpha


    1 GeneGo (Thomson Reuters) Pathway for CETP
        Cholesterol and Sphingolipids transport / Transport from Golgi and ER to the apical membrane (normal and CF)

    1 BioSystems Pathway for CETP
        Statin Pathway


    5/6        Reactome Pathways for CETP (see all 6)
        Lipid digestion, mobilization, and transport
    Metabolism
    Lipoprotein metabolism
    HDL-mediated lipid transport
    LDL-mediated lipid transport



    CETP for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CETP

    STRING Interaction Network Preview (showing 5 interactants - click image to see more details)

    5/7 Interacting proteins for CETP (P115973 ENSP000002006764) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    LPLP068583, ENSP000003097574I2D: score=2 STRING: ENSP00000309757
    APOA1P026473, ENSP000002368504I2D: score=1 STRING: ENSP00000236850
    EWSR1Q018443, ENSP000003810314I2D: score=3 STRING: ENSP00000381031
    ARPC3O151453I2D: score=3 
    APOBENSP000002332424STRING: ENSP00000233242
    About this table

    Gene Ontology (GO): 5/19 biological process terms (GO ID links to tree view) (see all 19):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0006641triglyceride metabolic process IDA2833496
    GO:0006869lipid transport IDA3818596
    GO:0006898receptor-mediated endocytosis TAS--
    GO:0008203cholesterol metabolic process IMP2586614
    GO:0010745negative regulation of macrophage derived foam cell differentiation IC16670775

    CETP for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CETP for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Compounds for CETP available from Tocris Bioscience    About this table
    CompoundAction CAS #
    SC 26196Selective delta6 desaturase inhibitor[218136-59-5]
    PF 429242Competitive inhibitor of SREBP site 1 protease[947303-87-9]
    R 59-022Diacylglycerol kinase inhibitor; increases PKC activity[93076-89-2]
    SKI IISelective non-lipid inhibitor of sphingosine kinase[312636-16-1]
    (+-)-Octanoylcarnitine chlorideIntermediate in lipid metabolism[18822-86-1]

    10/77 Novoseek inferred chemical compound relationships for CETP gene (see all 77)    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    torcetrapib 95.9 220 20026784 (6), 19522058 (5), 18808319 (4), 19164467 (4) (see all 91)
    cholesterol ester 92.8 171 15064092 (4), 14608418 (3), 11887180 (2), 8344921 (2) (see all 99)
    cholesterol 89.2 1527 18178167 (9), 8847481 (8), 7857368 (7), 12772435 (7) (see all 99)
    lipid 84.2 957 16905138 (6), 10582542 (6), 7738519 (5), 8908157 (5) (see all 99)
    phospholipid 74.8 207 8071605 (5), 11013306 (4), 8673633 (3), 8908157 (3) (see all 98)
    atorvastatin 70.2 42 17868678 (3), 10634817 (3), 12663600 (3), 16541186 (2) (see all 21)
    probucol 68.2 71 8509722 (6), 1903061 (5), 14642415 (4), 8447724 (4) (see all 21)
    sele 67.6 3 11341749 (1), 11714857 (1), 15076187 (1)
    niacin 67.5 31 18669886 (5), 19825813 (2), 17335774 (2), 16455013 (1) (see all 14)
    allergens 66.2 45 10069888 (3), 15347375 (2), 12002744 (2), 12589356 (2) (see all 33)

    1 PharmGKB related drug/compound annotation for CETP gene    About this table
    Drug/compound PharmGKB Annotation
    pravastatinCA  

    Search CenterWatch for drugs/clinical trials and news about CETP

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CETP gene: 
    NM_000078.2  

    Unigene Cluster for CETP:

    Cholesteryl ester transfer protein, plasma
    Hs.89538  [show with all ESTs]
    Unigene Representative Sequence: M30185
    4 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000200676(uc002eki.2) ENST00000379780(uc002ekj.2) ENST00000569082
    ENST00000566128

    miRNA
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    Additional mRNA sequence: 

    AK291586.1 AK297699.1 BC025739.1 BT020064.1 M30185.1 M83573.1 

    2 DOTS entries:

    DT.211078  DT.95088624 

    24/54 AceView cDNA sequences (see all 54):

    BQ879525 BC025739 BI771118 BQ068239 BI041061 AW196951 AL552260 NM_000078 
    M30185 M83573 BM919861 BI819550 CR599646 CR622658 AW291164 CD687574 
    BX343862 BV204428 BV183769 BM007900 BQ710590 BF515223 R89105 AA999853 

    GeneLoc Exon Structure

    2 Alternative Splicing Database (ASD) splice patterns (SP) for CETP    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3 ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13 ^ 14 ^ 15 ^ 16a · 16b
    SP1:                                                                                                            
    SP2:                                                        -                                                   


    ECgene alternative splicing isoforms for CETP

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CETP expression in normal human tissues (normalized intensities)      CETP embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: --
    CETP Expression
    About this image


    CETP expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/12 selected tissues (see all 12) fully expand
     
     Endothelium (Cardiovascular System)    fully expand to see all 9 entries
             Umbilical cord blood-derived endothelial progenitor cells
             Endothelial-like cells ( Derivation and purification of endothelial precursor cells...
             Human Cardiac Microvascular Endothelial Cells (HCMEC)   
     
     Lymph (Cardiovascular System)    fully expand to see all 3 entries
             Human Dermal Lymphatic Endothelial Cells (HDLEC)   
             lymph node   
     
     Dermis (Hematopoietic System)    fully expand to see all 2 entries
             Human Dermal Microvascular Endothelial Cells (HDMEC)   
     
     Intestine
             Human Intestinal Microvascular Endothelial Cells (HIMEC)   
     
     Heart (Cardiovascular System)
             Human Cardiac Microvascular Endothelial Cells (HCMEC)   

    See CETP Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CETP

    SOURCE GeneReport for Unigene cluster: Hs.89538

    UniProtKB/Swiss-Prot: CETP_HUMAN, P11597
    Tissue specificity: Expressed by the liver and secreted in plasma

        SABiosciences Expression via Pathway-Focused PCR Array including CETP: 
              Lipoprotein Signaling & Cholesterol Metabolism in human mouse rat

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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CETP

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of chordates.

    Orthologs for CETP gene from 4/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    oppossum
    (Monodelphis domestica)
    Mammalia CETP6
    cholesteryl ester transfer protein, plasma
    60(a)
    1 ↔ 1
    1(447942630-447970229)
    chicken
    (Gallus gallus)
    Aves CETP1 cholesteryl ester transfer protein, plasma 60.78(n)
    52.39(a)
      415645  NM_001034814.1  NP_001029986.1 
    lizard
    (Anolis carolinensis)
    Reptilia CETP6
    Uncharacterized protein
    46(a)
    1 ↔ 1
    GL344281.1(22178-49548)
    zebrafish
    (Danio rerio)
    Actinopterygii cetp1 cholesteryl ester transfer protein, plasma 53.54(n)
    45.3(a)
      492488  NM_001007360.1  NP_001007361.1 


    ENSEMBL Gene Tree for CETP (if available)
    TreeFam Gene Tree for CETP (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
      --

    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    UniProtKB/Swiss-Prot: CETP_HUMAN, P11597
    Polymorphism: Genetic variations in CETP define the high density lipoprotein cholesterol level quantitative trait
    locus 10 (HDLCQ10) [MIM:143470]


    10/801 SNPs in CETP are shown (see all 801)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0331004
    Hyperalphalipoproteinemia 1 (HALP1)4--see VAR_0331002 R C mis40--------
    VAR_0330994
    Hyperalphalipoproteinemia 1 (HALP1)4--see VAR_0330992 L P mis40--------
    rs23037901,2,4
    C,F,HHyperalphalipoproteinemia 1 (HALP1)4 pathogenic158030187(+) CTTCGA/GCATCA 2 D G mis113Minor allele frequency- G:0.01EA NS NA EU 8377
    rs1421174891,2
    Cuntested158008881(+) GGCATC/TGTGTG 2 I syn11Minor allele frequency- T:0.00NA 4552
    rs58821,2,4
    C,F,O,A,Hother158028987(+) AGTCCA/GTCCAG 2 I V mis137Minor allele frequency- G:0.43MN NS NA EA WA EU 11639
    rs284194041,2
    C--42863290(+) AGGGAA/GGGGAG 1 -- us2k1 tfbs3 trp33Minor allele frequency- G:0.00NA WA CSA 5
    rs767641591,2
    C--56994393(+) TATTTG/TGTTTT 1 -- us2k10--------
    rs616310851,2
    C--56994395(+) TTTGG-/T/TT  
            
    TTTTT
    1 -- us2k11NA 2
    rs784308031,2
    C--56994395(+) TTTGGG/TTTTTT 1 -- us2k10--------
    rs58170821,2
    C--56997349(+) ATCTC-/AAACAA 1 -- int14Minor allele frequency- A:0.40NS CSA 224

    HapMap Linkage Disequilibrium report for CETP (56995762 - 57017757 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 2 variations for CETP:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv524073CNV Loss19592680
    nsv527160CNV Gain19592680


    Human Gene Mutation Database (HGMD): CETP
    SABiosciences Cancer Mutation PCR Assays
    Search QIAGEN SeqTarget long-range PCR primers for resequencing CETP
    DNA2.0 Custom Variant and Variant Library Synthesis for CETP

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 118470   
    OMIM disorders: 607322  143470  
    UniProtKB/Swiss-Prot: CETP_HUMAN, P11597
  • Hyperalphalipoproteinemia 1 (HALP1) [MIM:143470]: A condition characterized by high levels of high
    density lipoprotein (HDL) and increased HDL cholesterol levels. Note=The disease is caused by mutations affecting
    the gene represented in this entry

  • 20/95 diseases for CETP (see all 95):    About MalaCards
    hyperalphalipoproteinemia    cetp deficiency    basilar artery insufficiency    cetp-related hyperalphalipoproteinemia
    atherosclerosis    coronary stenosis    peripheral vascular disease    hyperlipoproteinemia type iii
    food allergy    rosacea    benign recurrent intrahepatic cholestasis    aortic atherosclerosis
    coronary restenosis    familial hypercholesterolemia    vascular disease    hypoalphalipoproteinemias
    gallbladder disease    hypercholesterolemia    tangier disease    familial hyperlipidemia

    5 diseases from the University of Copenhagen DISEASES database for CETP:
    Atherosclerosis     Coronary heart disease     Diabetes mellitus     Familial hyperlipidemia
    Myocardial infarction

    CETP for disorders           About GeneDecksing


    Congresses - knowledge worth sharing:  
    Alzheimer's & Parkinson's Diseases Congress (ADPD) 18 - 22 March 2015

    10/86 Novoseek inferred disease relationships for CETP gene (see all 86)    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    cetp deficiency 97.3 366 8911072 (6), 15256762 (6), 2215607 (6), 11020466 (6) (see all 99)
    hyperalphalipoproteinemia 92.6 58 11887180 (3), 8333866 (3), 11020466 (3), 8350515 (2) (see all 29)
    atherosclerosis 78.1 272 10195942 (4), 17272756 (4), 16946130 (4), 15256762 (3) (see all 99)
    hypertriglyceridemia 74.6 34 1752964 (3), 8376576 (3), 8977446 (2), 7989603 (2) (see all 21)
    dyslipidemia 71.8 41 15842977 (2), 15529021 (2), 15185777 (1), 17700364 (1) (see all 28)
    hypercholesterolemia familial 71.3 36 7605391 (2), 1634194 (2), 15026427 (2), 7701533 (2) (see all 22)
    coronary heart disease 70 74 15377415 (2), 1975178 (2), 10861897 (2), 16098387 (2) (see all 45)
    hypoalphalipoproteinemia 68.8 6 7712672 (1), 9102177 (1), 7749855 (1), 7583547 (1)
    allergy food 65 11 17489047 (2), 13679821 (1), 17496422 (1), 15672475 (1) (see all 10)
    hypercholesterolemia 63.9 42 10192749 (3), 7749806 (2), 9246022 (2), 12444911 (2) (see all 29)

    Genatlas disease: CETP
    elevated lipoprotein,high density (HDL) with coronary heart disease (Japanese-American men)

    Genetic Association Database (GAD): CETP
    Human Genome Epidemiology (HuGE) Navigator: CETP (323 documents)

    Export disorders for CETP gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CETP gene, integrated from 9 sources (see all 1465):
    (articles sorted by number of sources associating them with CETP)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Organization of the human cholesteryl ester transfer protein gene. (PubMed id 2334701)1, 2, 3, 9 Agellon L.B....Tall A.R. (1990)
    2. Two novel missense mutations in the CETP gene in Japanese hyperalphalipoproteinemic subjects: high-throughput assay by Invader assay. (PubMed id 12091484)1, 2, 4 Nagano M.... Matsuzawa Y. (2002)
    3. Cloning and sequencing of human cholesteryl ester transfer protein cDNA. (PubMed id 3600759)1, 2, 3 Drayna D....Lawn R. (1987)
    4. Separating the mechanism-based and off-target actions of cholesteryl ester transfer protein inhibitors with CETP gene polymorphisms. (PubMed id 20026784)1, 4, 9 Sofat R....Casas J.P. (2010)
    5. Increased high-density lipoprotein levels caused by a common cholesteryl-ester transfer protein gene mutation. (PubMed id 2215607)1, 2, 9 Inazu A.... Tall A.R. (1990)
    6. Cholesteryl ester transfer protein (CETP) genotype an d reduced CETP levels associated with decreased prevalence of hypertension. (PubMed id 20511482)1, 4, 9 Schechter C.B....Atzmon G. (2010)
    7. Cholesteryl ester transfer protein gene haplotypes, plasma high-density lipoprotein levels and the risk of coronary heart disease. (PubMed id 17287950)1, 4, 9 McCaskie P.A....Palmer L.J. (2007)
    8. Prevalence and phenotypic spectrum of cholesteryl ester transfer protein gene mutations in Japanese hyperalphalipoproteinemia. (PubMed id 12482565)1, 4, 9 Maruyama T....Matsuzawa Y. (2003)
    9. Taq1B polymorphism of cholesteryl ester transfer prot ein (CETP) gene in primary combined hyperlipidaemia. (PubMed id 19491422)1, 4, 9 Hassanzadeh T....Paoli M. (2009)
    10. Association of cholesteryl ester transfer protein genotypes with CETP mass and activity, lipid levels, and coronary risk. (PubMed id 18560005)1, 4, 9 Thompson A....Danesh J. (2008)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 1071 HGNC: 1869 AceView: CETP Ensembl:ENSG00000087237 euGenes: HUgn1071
    ECgene: CETP H-InvDB: CETP

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CETP Pharmacogenomics, SNPs, Pathways
    SHMPDhttp://shmpd.bii.a-star.edu.sg/gene.php?genestart=A&genename=CETP
    Wikipedia http://en.wikipedia.org/wiki/Cholesterylester_transfer_protein

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CETP gene:
    Search GeneIP for patents involving CETP

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Sirion Biotech, Cell lines from GenScript, and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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