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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CETN3 Gene

protein-coding GIFtS: 53
GCID: GC05M089688

centrin, EF-hand protein, 3

(Previous names: centrin, EF-hand protein, 3 (CDC31 yeast homolog) )

Explore 3 diseases affiliated with
CETN3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Centrin, EF-Hand Protein, 3¹ ²		Centrin, EF-Hand Protein, 3 (CDC31 Homolog, Yeast)²
CEN3¹ ² ³		Centrin-3¹
Centrin, EF-Hand Protein, 3 (CDC31 Yeast Homolog)¹		EF-Hand Superfamily Member²
CDC31 Yeast Homolog²

External Ids:	HGNC: 1868¹	Entrez Gene: 1070²	Ensembl: ENSG00000153140⁷	OMIM: 602907⁵	UniProtKB: O15182³

Export aliases for CETN3 gene to outside databases

Previous GC identifers: GC05M088717 GC05M089980 GC05M089727 GC05M089773 GC05M089725 GC05M084900

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CETN3:

The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein

family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is

located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication

and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other

mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be

one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast

counterpart. (provided by RefSeq, Jul 2008)

UniProtKB/Swiss-Prot: CETN3_HUMAN, O15182

Function: Plays a fundamental role in microtubule-organizing center structure and function

Gene Wiki entry for CETN3

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000005.9 NC_018916.1 NT_006713.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CETN3 gene promoter:
AML1a POU2F1 POU2F1a FOXO1a FOXO1 Evi-1
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CETN3 promoter sequence

Search SABiosciences Chromatin IP Primers for CETN3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CETN3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 5q14.3 Ensembl cytogenetic band: 5q14.3 HGNC cytogenetic band: 5q14.3

CETN3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CETN3 gene location

GeneLoc information about chromosome 5 GeneLoc Exon Structure

GeneLoc location for GC05M089688: view genomic region (about GC identifiers)

Start:	89,688,078 bp from pter	End:	89,705,603 bp from pter
Size:	17,526 bases	Orientation:	minus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: CETN3_HUMAN, O15182 (See protein sequence)

Recommended Name: Centrin-3

Size: 167 amino acids; 19550 Da

Subunit: Monomer (By similarity)

Subcellular location: Cytoplasm, cytoskeleton, centrosome. Note=Centrosome of interphase and mitotic cells

Secondary accessions: Q53YD2 Q9BS23

Explore the universe of human proteins at neXtProt for CETN3: NX_O15182

Post-translational modifications:

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_O15182

CETN3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins: NP_004356.2

ENSEMBL proteins:

ENSP00000283122 ENSP00000428259 ENSP00000430361 ENSP00000429772 ENSP00000430409

ENSP00000429875

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Gene Ontology (GO): 5/6 cellular component terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005737	cytoplasm	IDA	--
GO:0005813	centrosome	IDA	--
GO:0005814	centriole	IEA	--
GO:0005932	microtubule basal body	IEA	--
GO:0032391	photoreceptor connecting cilium	IEA	--

CETN3 for ontologies About GeneDecksing

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(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CETN3 for domains About GeneDecksing

3 InterPro domains/families:

IPR011992 EF-hand-like_dom

IPR002048 EF_hand_Ca-bd

IPR018247 EF_Hand_1_Ca_BS

Graphical View of Domain Structure for InterPro Entry O15182

ProtoNet protein and cluster: O15182

UniProtKB/Swiss-Prot: CETN3_HUMAN, O15182

Similarity: Belongs to the centrin family

Similarity: Contains 4 EF-hand domains

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, Sirion Biotech, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, Sirion Biotech, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Molecular Function:

UniProtKB/Swiss-Prot Summary: CETN3_HUMAN, O15182

Function: Plays a fundamental role in microtubule-organizing center structure and function

Gene Ontology (GO): 3 molecular function terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005509	calcium ion binding	IEA	--
GO:0008017	microtubule binding	IEA	--
GO:0031683	G-protein beta/gamma-subunit complex binding	IEA	--

CETN3 for ontologies About GeneDecksing

Phenotypes:
2 GenomeRNAi human phenotypes for CETN3:

Increased cell death in breast

Increased gamma-H2AX phosphory

Animal Models:

inGenious Targeting Laboratory - Customizable classic, inducible, and humanized mouse model solutions for CETN3

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In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CETN3

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CETN3

STRING Interaction Network Preview (showing 5 interactants - click image to see 8)

5/71 Interacting proteins for CETN3 (O15182^{2, 3} ENSP00000283122⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 71)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
HIST1H4A	P62805³	I2D: score=1
HIST1H4B	P62805³	I2D: score=1
HIST1H4C	P62805³	I2D: score=1
HIST1H4D	P62805³	I2D: score=1
HIST1H4E	P62805³	I2D: score=1

About this table

Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0007067	mitosis	IEA	--
GO:0007098	centrosome cycle	TAS	9256449
GO:0051301	cell division	IEA	--

CETN3 for ontologies About GeneDecksing

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CETN3
Search CenterWatch for drugs/clinical trials and news about CETN3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
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Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CETN3 gene:

NM_004365.2

Unigene Cluster for CETN3:

Centrin, EF-hand protein, 3

Hs.591767 [show with all ESTs]

Unigene Representative Sequence: BF218841

6 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000283122(uc003kjo.3) ENST00000522083 ENST00000522864 ENST00000518458

ENST00000522565 ENST00000522842

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		hsa-miR-133a hsa-miR-133b
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Additional cDNA sequence:

BC005383.1 BC093793.1 BC112040.1 BT006688.1 CR450346.1 Y12473.1

6 DOTS entries:

DT.316013 DT.95169524 DT.95355816 DT.100819485 DT.91768596 DT.75122641

24/202 AceView cDNA sequences (see all 202):

CB157894 AI075035 AA876260 CB160616 AA291295 AA372190 CA771197 AW961403

BI439055 BG533064 AI371271 AA628204 BG542073 BE046504 BU617349 CA430726

AA417010 BU740197 AW296966 AW958093 BF589356 CB156152 AI056696 BM722364

GeneLoc Exon Structure

3 Alternative Splicing Database (ASD) splice patterns (SP) for CETN3 About this scheme

ExUns:	1	^	2a	·	2b	^	3	^	4a	·	4b	·	4c
SP1:					-
SP2:
SP3:							-

ECgene alternative splicing isoforms for CETN3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CETN3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGAAAAAAAC

About this image

CETN3 expression in embryonic tissues and stem cells
Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

1 LifeMap In Vivo Development Anatomical Compartment/Cell

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Eye

Retina

Eye

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CETN3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CETN3

SOURCE GeneReport for Unigene cluster: Hs.591767

SABiosciences Custom PCR Arrays for CETN3

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In Situ
Assay Products:

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(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals and fungi.

Orthologs for CETN3 gene from 7/27 species (see all 27) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
mouse (Mus musculus)	Mammalia	Cetn3^{1 , 5}	centrin 3^{1, 5}	89.02(n)¹ 98.8(a)¹		13 (43.68 cM)⁵ 12626¹ NM_007684.3¹ NP_031710.1¹ 81783292⁵
chicken (Gallus gallus)	Aves	CETN3¹	centrin, EF-hand protein, 3	86.63(n) 94.01(a)		427104 XM_424696.2 XP_424696.2
lizard (Anolis carolinensis)	Reptilia	CETN3⁶	--	90(a)	1 ↔ 1	4(104451020-104456329)
African clawed frog (Xenopus laevis)	Amphibia	Xl.703²	Xenopus laevis transcribed sequence with moderate similarity more	79.61(n)		CA983293.1
zebrafish (Danio rerio)	Actinopterygii	cetn3¹	centrin 3	77.31(n) 83.73(a)		552931 NM_001020499.1 NP_001018335.1
honey bee (Apis mellifera)	Insecta	--	--	39(a)	1 ↔ 1	Group9.11(284888-285630)
baker's yeast (Saccharomyces cerevisiae)	Saccharomycetes	CDC31(YOR257W)⁴ CDC31¹	Calcium-binding component of the spindle pole body more⁴ Cdc31p¹	64.58(n)¹ 61.81(a)¹		15(811008-811493)⁴ 854431^{1, 4} NP_014900.3¹ NP_014900.1⁴

ENSEMBL Gene Tree for CETN3 (if available)
TreeFam Gene Tree for CETN3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CETN3 gene

EFCAB2² CETN2² CETN1²

18/20 SIMAP similar genes for CETN3 using alignment to 7 protein entries: CETN3_HUMAN (see all proteins) (see all similar genes):

CETN2 CETN1 CALM3 CALM2 CALM1 CALML3

CALML5 TNNC2 EFCAB2 CABP1 CABP5 TNNC1

CABP2 MYL5 MYL2 MYL1 ACTN4 MYL6

CETN3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 5 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs75619683^1,2	F	--	89689067(+)	`GTTTTC/ATATTT`	1	--	ds500¹		1		WA	118
rs10514326^1,2	C,F,H	--	89689226(+)	`TTACAA/TTGATA`	1	--	ds500¹		18		NS EA NA WA	1310
rs181135141^1,2		--	89689439(+)	`TGTTTC/TAGAAA`	1	--	ds500¹		0	--	--	--	--
rs78613014^1,2		--	89689478(+)	`GAAATA/CCACTC`	1	--	ds500¹		0	--	--	--	--
rs184829496^1,2		--	89689542(+)	`CTAATA/GAAATA`	1	--	ut3¹		0	--	--	--	--
rs189352555^1,2		--	89689561(+)	`ATTAAC/TGAAAG`	1	--	ut3¹		0	--	--	--	--
rs148176689^1,2	C	--	89689973(+)	`TTATTC/TTTTCA`	1	--	int¹		0	--	--	--	--
rs180876421^1,2		--	89689992(+)	`GACTAC/TCATTT`	1	--	int¹		0	--	--	--	--
rs144073894^1,2		--	89690133(+)	`ATAATA/GTGATA`	1	--	int¹		0	--	--	--	--
rs187231634^1,2		--	89690141(+)	`ATAAAC/TATTAC`	1	--	int¹		0	--	--	--	--

HapMap Linkage Disequilibrium report for CETN3 (89688078 - 89705603 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CETN3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CETN3

DNA2.0 Custom Variant and Variant Library Synthesis for CETN3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CETN3 for disorders           About GeneDecksing

OMIM gene information: 602907    OMIM disorders: --

3 diseases for CETN3:    About MalaCards

insulin resistance breast cancer malaria

Human Genome Epidemiology (HuGE) Navigator: CETN3 (1 document)

Export disorders for CETN3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CETN3 gene, integrated from 9 sources (see all 24):
(articles sorted by number of sources associating them with CETN3)

Utopia: connect your pdf to the dynamic
world of online information

Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene. (PubMed id 9256449)^{1, 2, 3} Middendorp S.... Bornens M. (1997)
The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)^{1, 2} Gerhard D.S....Malek J. (2004)
Calcium and magnesium binding to human centrin 3 and interaction with target peptides. (PubMed id 15654740)^{1, 9} Cox J.A....Craescu C.T. (2005)
Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro. (PubMed id 10725219)^{1, 9} Laoukili J....Tournier F. (2000)
A proteome-wide, quantitative survey of in vivo ubiqui tylation sites reveals widespread regulatory roles. (PubMed id 21890473)¹ Wagner S.A....Choudhary C. (2011)
Systematic analysis of human protein complexes identi fies chromosome segregation proteins. (PubMed id 20360068)¹ Hutchins J.R....Peters J.M. (2010)
Centrosome-related genes, genetic variation, and risk of breast cancer. (PubMed id 20508983)¹ Olson J.E....Couch F.J. (2010)
Expanding the substantial interactome of NEMO using p rotein microarrays. (PubMed id 20098747)¹ Fenner B.J....Prehn J.H. (2010)
Genetic variant near IRS1 is associated with type 2 d iabetes, insulin resistance and hyperinsulinemia. (PubMed id 19734900)¹ Rung J....Sladek R. (2009)
Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)¹ Sowa M.E....Harper J.W. (2009)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 1070	HGNC: 1868	AceView: CETN3	Ensembl:ENSG00000153140	euGenes: HUgn1070
ECgene: CETN3	H-InvDB: CETN3

(According to HUGE)
About This Section

(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section

Name	Description
PharmGKB entry for CETN3	Pharmacogenomics, SNPs, Pathways

Intellectual Property for CETN3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

About This Section

Patent Information for CETN3 gene:
Search GeneIP for patents involving CETN3

GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search

(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0 and Sirion Biotech, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript, LifeMap BioReagents, and Sirion Biotech, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or Enzo Life Sciences, In Situ Hybridization Assays from
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centrin, EF-hand protein, 3

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centrin, EF-hand protein, 3

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