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Aliases for CETN3 Gene

Aliases for CETN3 Gene

  • Centrin 3 2 3 5
  • EF-Hand Superfamily Member 2 3
  • CDC31 Yeast Homolog 2 3
  • CEN3 3 4
  • Centrin, EF-Hand Protein, 3 (CDC31 Homolog, Yeast) 3
  • Centrin, EF-Hand Protein, 3 (CDC31 Yeast Homolog) 2
  • Centrin, EF-Hand Protein, 3 2
  • Centrin-3 3
  • CDC31 3

External Ids for CETN3 Gene

Previous GeneCards Identifiers for CETN3 Gene

  • GC05M088717
  • GC05M089980
  • GC05M089727
  • GC05M089773
  • GC05M089725
  • GC05M084900
  • GC05M089688

Summaries for CETN3 Gene

Entrez Gene Summary for CETN3 Gene

  • The protein encoded by this gene contains four EF-hand calcium binding domains, and is a member of the centrin protein family. Centrins are evolutionarily conserved proteins similar to the CDC31 protein of S. cerevisiae. Yeast CDC31 is located at the centrosome of interphase and mitotic cells, where it plays a fundamental role in centrosome duplication and separation. Multiple forms of the proteins similar to the yeast centrin have been identified in human and other mammalian cells, some of which have been shown to be associated with centrosome fractions. This protein appears to be one of the most abundant centrins associated with centrosome, which suggests a similar function to its yeast counterpart. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2014]

GeneCards Summary for CETN3 Gene

CETN3 (Centrin 3) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and G-protein beta/gamma-subunit complex binding. An important paralog of this gene is CETN1.

UniProtKB/Swiss-Prot for CETN3 Gene

  • Plays a fundamental role in microtubule-organizing center structure and function.

  • Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed:22307388).

Gene Wiki entry for CETN3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CETN3 Gene

Genomics for CETN3 Gene

Regulatory Elements for CETN3 Gene

Enhancers for CETN3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CETN3 on UCSC Golden Path with GeneCards custom track

Promoters for CETN3 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Genomic Location for CETN3 Gene

Chromosome:
5
Start:
90,392,261 bp from pter
End:
90,409,786 bp from pter
Size:
17,526 bases
Orientation:
Minus strand

Genomic View for CETN3 Gene

Genes around CETN3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CETN3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CETN3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CETN3 Gene

Proteins for CETN3 Gene

  • Protein details for CETN3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O15182-CETN3_HUMAN
    Recommended name:
    Centrin-3
    Protein Accession:
    O15182
    Secondary Accessions:
    • Q53YD2
    • Q9BS23

    Protein attributes for CETN3 Gene

    Size:
    167 amino acids
    Molecular mass:
    19550 Da
    Quaternary structure:
    • Monomer (By similarity). Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388).

neXtProt entry for CETN3 Gene

Post-translational modifications for CETN3 Gene

  • Ubiquitination at Lys 108 and Lys 117
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CETN3 Gene

Domains & Families for CETN3 Gene

Gene Families for CETN3 Gene

Protein Domains for CETN3 Gene

Suggested Antigen Peptide Sequences for CETN3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

O15182

UniProtKB/Swiss-Prot:

CETN3_HUMAN :
  • Contains 4 EF-hand domains.
  • Belongs to the centrin family.
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the centrin family.
genes like me logo Genes that share domains with CETN3: view

Function for CETN3 Gene

Molecular function for CETN3 Gene

UniProtKB/Swiss-Prot Function:
Plays a fundamental role in microtubule-organizing center structure and function.
UniProtKB/Swiss-Prot Function:
Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed:22307388).

Gene Ontology (GO) - Molecular Function for CETN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 25416956
GO:0008017 microtubule binding IEA --
GO:0031683 G-protein beta/gamma-subunit complex binding IEA --
genes like me logo Genes that share ontologies with CETN3: view
genes like me logo Genes that share phenotypes with CETN3: view

Animal Model Products

CRISPR Products

miRNA for CETN3 Gene

miRTarBase miRNAs that target CETN3

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CETN3

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CETN3 Gene

Localization for CETN3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CETN3 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Nucleus, nucleolus. Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Note=Centrosome of interphase and mitotic cells (PubMed:9256449). Localizes to centriole distal lumen (PubMed:26337392). {ECO:0000269 PubMed:26337392, ECO:0000269 PubMed:9256449}.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CETN3 Gene COMPARTMENTS Subcellular localization image for CETN3 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3
extracellular 1

Gene Ontology (GO) - Cellular Components for CETN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005730 nucleolus IEA --
GO:0005813 centrosome IDA 21399614
GO:0005814 centriole IEA,IDA 26337392
GO:0032391 photoreceptor connecting cilium IEA --
GO:0035869 ciliary transition zone IEA --
genes like me logo Genes that share ontologies with CETN3: view

Pathways & Interactions for CETN3 Gene

SuperPathways for CETN3 Gene

No Data Available

SIGNOR curated interactions for CETN3 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CETN3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007067 mitotic nuclear division IEA --
GO:0007098 centrosome cycle TAS 9256449
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CETN3: view

No data available for Pathways by source for CETN3 Gene

Drugs & Compounds for CETN3 Gene

No Compound Related Data Available

Transcripts for CETN3 Gene

Unigene Clusters for CETN3 Gene

Centrin, EF-hand protein, 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CETN3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CETN3 Gene

ExUns: 1 ^ 2a · 2b ^ 3 ^ 4a · 4b · 4c
SP1: -
SP2:
SP3: -

Relevant External Links for CETN3 Gene

GeneLoc Exon Structure for
CETN3
ECgene alternative splicing isoforms for
CETN3

Expression for CETN3 Gene

mRNA expression in normal human tissues for CETN3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CETN3 Gene

This gene is overexpressed in Testis (x6.0).

Protein differential expression in normal tissues from HIPED for CETN3 Gene

This gene is overexpressed in Lung (25.3), Peripheral blood mononuclear cells (10.4), Bone (8.9), and Ovary (8.6).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CETN3 Gene



Protein tissue co-expression partners for CETN3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CETN3 Gene:

CETN3

SOURCE GeneReport for Unigene cluster for CETN3 Gene:

Hs.591767
genes like me logo Genes that share expression patterns with CETN3: view

Primer Products

No data available for mRNA Expression by UniProt/SwissProt for CETN3 Gene

Orthologs for CETN3 Gene

This gene was present in the common ancestor of animals and fungi.

Orthologs for CETN3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CETN3 34
  • 95.81 (n)
  • 98.2 (a)
CETN3 35
  • 99 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CETN3 34
  • 96.81 (n)
  • 99.4 (a)
CETN3 35
  • 99 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cetn3 34
  • 89.02 (n)
  • 98.8 (a)
Cetn3 16
Cetn3 35
  • 99 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CETN3 34
  • 100 (n)
  • 100 (a)
CETN3 35
  • 87 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia CETN3 35
  • 98 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CETN3 35
  • 93 (a)
OneToOne
chicken
(Gallus gallus)
Aves CETN3 34
  • 86.63 (n)
  • 94.01 (a)
CETN3 35
  • 83 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CETN3 35
  • 90 (a)
OneToOne
tropical clawed frog
(Silurana tropicalis)
Amphibia cetn3 34
  • 80.24 (n)
  • 89.82 (a)
Str.1142 34
African clawed frog
(Xenopus laevis)
Amphibia Xl.703 34
zebrafish
(Danio rerio)
Actinopterygii cetn3 34
  • 77.31 (n)
  • 83.73 (a)
cetn3 35
  • 84 (a)
OneToOne
fruit fly
(Drosophila melanogaster)
Insecta CG13898 35
  • 29 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea pat-10 35
  • 27 (a)
ManyToMany
A. gosspyii yeast
(Ashbya gossypii)
Saccharomycetes AGOS_AAL110C 34
  • 57.31 (n)
  • 60.27 (a)
K. lactis yeast
(Kluyveromyces lactis)
Saccharomycetes KLLA0C09669g 34
  • 64.25 (n)
  • 62.5 (a)
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC31 34
  • 64.58 (n)
  • 61.81 (a)
CDC31 35
  • 57 (a)
OneToMany
CDC31 37
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.6098 34
fission yeast
(Schizosaccharomyces pombe)
Schizosaccharomycetes cdc31 34
  • 66.21 (n)
  • 66.21 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 77 (a)
OneToOne
Species where no ortholog for CETN3 was found in the sources mined by GeneCards:
  • Actinobacteria (Mycobacterium tuberculosis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rat (Rattus norvegicus)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CETN3 Gene

ENSEMBL:
Gene Tree for CETN3 (if available)
TreeFam:
Gene Tree for CETN3 (if available)

Paralogs for CETN3 Gene

Paralogs for CETN3 Gene

genes like me logo Genes that share paralogs with CETN3: view

Variants for CETN3 Gene

Sequence variations from dbSNP and Humsavar for CETN3 Gene

SNP ID Clin Chr 05 pos Sequence Context AA Info Type
rs4873 - 90,407,824(-) AGCTT(C/G)TAGTG reference, missense
rs10043250 -- 90,395,613(+) acagg(A/C)atggg intron-variant
rs12517137 -- 90,402,831(+) CCTAT(A/C)TTTAC intron-variant
rs34062139 -- 90,411,775(+) TGTTT(-/A)CTCAC upstream-variant-2KB
rs76985464 -- 90,401,218(+) AAATG(C/T)AGCTT intron-variant

Variation tolerance for CETN3 Gene

Residual Variation Intolerance Score: 36.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 7.73; 83.15% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CETN3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CETN3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Structural Variations from Database of Genomic Variants (DGV) for CETN3 Gene

Disorders for CETN3 Gene

Relevant External Links for CETN3

Genetic Association Database (GAD)
CETN3
Human Genome Epidemiology (HuGE) Navigator
CETN3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CETN3

No disorders were found for CETN3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CETN3 Gene

Publications for CETN3 Gene

  1. Identification of a new mammalian centrin gene, more closely related to Saccharomyces cerevisiae CDC31 gene. (PMID: 9256449) Middendorp S. … Bornens M. (Proc. Natl. Acad. Sci. U.S.A. 1997) 2 3 4 65
  2. MDM1 is a microtubule-binding protein that negatively regulates centriole duplication. (PMID: 26337392) Van de Mark D. … Stearns T. (Mol. Biol. Cell 2015) 3 4 65
  3. Centrosome-related genes, genetic variation, and risk of breast cancer. (PMID: 20508983) Olson J.E. … Couch F.J. (Breast Cancer Res. Treat. 2011) 3 46 65
  4. Genetic variant near IRS1 is associated with type 2 diabetes, insulin resistance and hyperinsulinemia. (PMID: 19734900) Rung J. … Sladek R. (Nat. Genet. 2009) 3 46 65
  5. Calcium and magnesium binding to human centrin 3 and interaction with target peptides. (PMID: 15654740) Cox J.A. … Craescu C.T. (Biochemistry 2005) 3 22 65

Products for CETN3 Gene

Sources for CETN3 Gene

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