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Aliases for CETN2 Gene

Aliases for CETN2 Gene

  • Centrin 2 2 3 5
  • Centrin, EF-Hand Protein, 2 2 3
  • CALT 3 4
  • CEN2 3 4
  • Caltractin (20kD Calcium-Binding Protein) 3
  • Caltractin Isoform 1 4

External Ids for CETN2 Gene

Previous HGNC Symbols for CETN2 Gene

  • CALT

Previous GeneCards Identifiers for CETN2 Gene

  • GC0XM146335
  • GC0XM148653
  • GC0XM149743
  • GC0XM150613
  • GC0XM151666
  • GC0XM151746
  • GC0XM151996

Summaries for CETN2 Gene

Entrez Gene Summary for CETN2 Gene

  • Caltractin belongs to a family of calcium-binding proteins and is a structural component of the centrosome. The high level of conservation from algae to humans and its association with the centrosome suggested that caltractin plays a fundamental role in the structure and function of the microtubule-organizing center, possibly required for the proper duplication and segregation of the centrosome. [provided by RefSeq, Jul 2008]

GeneCards Summary for CETN2 Gene

CETN2 (Centrin 2) is a Protein Coding gene. Diseases associated with CETN2 include xeroderma pigmentosum, variant type and xeroderma pigmentosum, group c. Among its related pathways are Nucleotide excision repair and Cytoskeletal Signaling. GO annotations related to this gene include nucleic acid binding and microtubule binding. An important paralog of this gene is CETN3.

UniProtKB/Swiss-Prot for CETN2 Gene

  • Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.

  • Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.

  • The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5-to-3 direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.

  • Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed:22307388).

Gene Wiki entry for CETN2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CETN2 Gene

Genomics for CETN2 Gene

Regulatory Elements for CETN2 Gene

Enhancers for CETN2 Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CETN2 on UCSC Golden Path with GeneCards custom track

Promoters for CETN2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

ENSRs around CETN2 on UCSC Golden Path with GeneCards custom track

Genomic Location for CETN2 Gene

Chromosome:
X
Start:
152,826,973 bp from pter
End:
152,830,777 bp from pter
Size:
3,805 bases
Orientation:
Minus strand

Genomic View for CETN2 Gene

Genes around CETN2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CETN2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CETN2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CETN2 Gene

Proteins for CETN2 Gene

  • Protein details for CETN2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    P41208-CETN2_HUMAN
    Recommended name:
    Centrin-2
    Protein Accession:
    P41208
    Secondary Accessions:
    • B2R4T4
    • Q53XW1

    Protein attributes for CETN2 Gene

    Size:
    172 amino acids
    Molecular mass:
    19738 Da
    Quaternary structure:
    • Monomer. Homooligomer. Interacts with CCP110, SFI1. Component of the XPC complex composed of XPC, RAD23B and CETN2. Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388).
    Miscellaneous:
    • Binds two moles of calcium per mole of protein.

    Three dimensional structures from OCA and Proteopedia for CETN2 Gene

neXtProt entry for CETN2 Gene

Proteomics data for CETN2 Gene at MOPED

Post-translational modifications for CETN2 Gene

  • Ubiquitination at Lys 111
  • Modification sites at PhosphoSitePlus

Other Protein References for CETN2 Gene

ENSEMBL proteins:
REFSEQ proteins:

Antibody Products

  • Cell Signaling Technology (CST) Antibodies for CETN2 (CETN2)

No data available for DME Specific Peptides for CETN2 Gene

Domains & Families for CETN2 Gene

Gene Families for CETN2 Gene

Protein Domains for CETN2 Gene

Suggested Antigen Peptide Sequences for CETN2 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

P41208

UniProtKB/Swiss-Prot:

CETN2_HUMAN :
  • Contains 4 EF-hand domains.
  • Belongs to the centrin family.
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the centrin family.
genes like me logo Genes that share domains with CETN2: view

Function for CETN2 Gene

Molecular function for CETN2 Gene

UniProtKB/Swiss-Prot Function:
Plays a fundamental role in microtubule organizing center structure and function. Required for centriole duplication and correct spindle formation. Has a role in regulating cytokinesis and genome stability via cooperation with CALM1 and CCP110.
UniProtKB/Swiss-Prot Function:
Involved in global genome nucleotide excision repair (GG-NER) by acting as component of the XPC complex. Cooperatively with RAD23B appears to stabilize XPC. In vitro, stimulates DNA binding of the XPC:RAD23B dimer.
UniProtKB/Swiss-Prot Function:
The XPC complex is proposed to represent the first factor bound at the sites of DNA damage and together with other core recognition factors, XPA, RPA and the TFIIH complex, is part of the pre-incision (or initial recognition) complex. The XPC complex recognizes a wide spectrum of damaged DNA characterized by distortions of the DNA helix such as single-stranded loops, mismatched bubbles or single-stranded overhangs. The orientation of XPC complex binding appears to be crucial for inducing a productive NER. XPC complex is proposed to recognize and to interact with unpaired bases on the undamaged DNA strand which is followed by recruitment of the TFIIH complex and subsequent scanning for lesions in the opposite strand in a 5-to-3 direction by the NER machinery. Cyclobutane pyrimidine dimers (CPDs) which are formed upon UV-induced DNA damage esacpe detection by the XPC complex due to a low degree of structural perurbation. Instead they are detected by the UV-DDB complex which in turn recruits and cooperates with the XPC complex in the respective DNA repair.
UniProtKB/Swiss-Prot Function:
Component of the TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3 (PubMed:22307388). The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery (PubMed:22307388).
genes like me logo Genes that share phenotypes with CETN2: view

Animal Models for CETN2 Gene

MGI Knock Outs for CETN2:

Animal Model Products

miRNA for CETN2 Gene

miRTarBase miRNAs that target CETN2

No data available for Enzyme Numbers (IUBMB) , Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Transcription Factor Targets and HOMER Transcription for CETN2 Gene

Localization for CETN2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CETN2 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome, centriole. Nucleus. Note=Centrosome of S-phase, interphase and mitotic cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CETN2 Gene COMPARTMENTS Subcellular localization image for CETN2 gene
Compartment Confidence
cytoskeleton 5
cytosol 5
nucleus 5

Gene Ontology (GO) - Cellular Components for CETN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005654 nucleoplasm TAS --
GO:0032391 photoreceptor connecting cilium IEA --
genes like me logo Genes that share ontologies with CETN2: view

Pathways & Interactions for CETN2 Gene

genes like me logo Genes that share pathways with CETN2: view

Pathways by source for CETN2 Gene

1 KEGG pathway for CETN2 Gene

SIGNOR curated interactions for CETN2 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CETN2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000086 G2/M transition of mitotic cell cycle TAS --
GO:0000717 nucleotide-excision repair, DNA duplex unwinding TAS --
GO:0006996 organelle organization TAS --
GO:0016925 protein sumoylation TAS --
GO:0032465 regulation of cytokinesis IMP 16760425
genes like me logo Genes that share ontologies with CETN2: view

Drugs & Compounds for CETN2 Gene

(1) Drugs for CETN2 Gene - From: HMDB and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CETN2: view

Transcripts for CETN2 Gene

mRNA/cDNA for CETN2 Gene

Unigene Clusters for CETN2 Gene

Centrin, EF-hand protein, 2:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CETN2 Gene

ExUns: 1a · 1b · 1c ^ 2a · 2b ^ 3a · 3b · 3c ^ 4a · 4b ^ 5a · 5b
SP1: - -
SP2: - - - -
SP3: -
SP4:

Relevant External Links for CETN2 Gene

GeneLoc Exon Structure for
CETN2
ECgene alternative splicing isoforms for
CETN2

Expression for CETN2 Gene

mRNA expression in normal human tissues for CETN2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

Protein differential expression in normal tissues from HIPED for CETN2 Gene

This gene is overexpressed in Peripheral blood mononuclear cells (15.9).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CETN2 Gene



SOURCE GeneReport for Unigene cluster for CETN2 Gene Hs.82794

genes like me logo Genes that share expression patterns with CETN2: view

Protein tissue co-expression partners for CETN2 Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA differential expression in normal tissues and mRNA Expression by UniProt/SwissProt for CETN2 Gene

Orthologs for CETN2 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CETN2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CETN2 35
  • 90.5 (n)
  • 97.09 (a)
CETN2 36
  • 97 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CETN2 35
  • 90.12 (n)
  • 97.67 (a)
CETN2 36
  • 82 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cetn2 35
  • 90.89 (n)
  • 95.93 (a)
Cetn2 16
Cetn2 36
  • 96 (a)
OneToOne
chimpanzee
(Pan troglodytes)
Mammalia CETN2 35
  • 99.81 (n)
  • 100 (a)
CETN2 36
  • 100 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Cetn2 35
  • 90.31 (n)
  • 97.09 (a)
oppossum
(Monodelphis domestica)
Mammalia CETN2 36
  • 46 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CETN2 36
  • 92 (a)
OneToOne
chicken
(Gallus gallus)
Aves CETN2 35
  • 79.46 (n)
  • 88.95 (a)
CETN1 36
  • 84 (a)
ManyToMany
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 74 (a)
ManyToMany
tropical clawed frog
(Silurana tropicalis)
Amphibia cetn1 35
  • 77.13 (n)
  • 85.47 (a)
Str.6505 35
zebrafish
(Danio rerio)
Actinopterygii cetn2 35
LOC100006257 35
  • 70.54 (n)
  • 80.81 (a)
cetn2 36
  • 81 (a)
OneToMany
rainbow trout
(Oncorhynchus mykiss)
Actinopterygii Omy.838 35
fruit fly
(Drosophila melanogaster)
Insecta CG17493 37
  • 72 (a)
CG17493 35
  • 65.25 (n)
  • 72.12 (a)
CG17493 36
  • 65 (a)
ManyToMany
CG31802 36
  • 56 (a)
ManyToMany
African malaria mosquito
(Anopheles gambiae)
Insecta AgaP_AGAP009260 35
  • 69.75 (n)
  • 78.4 (a)
worm
(Caenorhabditis elegans)
Secernentea B0563.7 36
  • 24 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC31 36
  • 55 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CEN2 35
  • 67.35 (n)
  • 58.5 (a)
soybean
(Glycine max)
eudicotyledons Gma.1826 35
rice
(Oryza sativa)
Liliopsida Os07g0618800 35
  • 61.57 (n)
  • 52.87 (a)
sea squirt
(Ciona intestinalis)
Ascidiacea Cin.1446 35
Species with no ortholog for CETN2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • wheat (Triticum aestivum)

Evolution for CETN2 Gene

ENSEMBL:
Gene Tree for CETN2 (if available)
TreeFam:
Gene Tree for CETN2 (if available)

Paralogs for CETN2 Gene

Paralogs for CETN2 Gene

(27) SIMAP similar genes for CETN2 Gene using alignment to 1 proteins:

Pseudogenes.org Pseudogenes for CETN2 Gene

genes like me logo Genes that share paralogs with CETN2: view

Variants for CETN2 Gene

Sequence variations from dbSNP and Humsavar for CETN2 Gene

SNP ID Clin Chr 0X pos Sequence Context AA Info Type
rs8230 -- 152,827,362(-) TATTT(G/T)TTTTG utr-variant-3-prime
rs2301188 -- 152,828,729(+) TTACT(A/C)CTGTC intron-variant
rs3088344 -- 152,827,242(+) GTTTT(G/T)TATCT downstream-variant-500B
rs6627689 -- 152,827,019(+) GTTGC(A/G)TTAGC downstream-variant-500B
rs6653487 -- 152,828,151(+) GAATA(C/G)ATAAT intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CETN2 Gene

Variant ID Type Subtype PubMed ID
dgv2493e1 CNV Complex 17122850
nsv470373 CNV Gain 18288195
esv25868 CNV Gain 19812545

Variation tolerance for CETN2 Gene

Residual Variation Intolerance Score: 31.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 0.02; 0.46% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CETN2 Gene

HapMap Linkage Disequilibrium report
CETN2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CETN2 Gene

Disorders for CETN2 Gene

MalaCards: The human disease database

(2) MalaCards diseases for CETN2 Gene - From: DISEASES, Novoseek, and GeneCards

Disorder Aliases PubMed IDs
xeroderma pigmentosum, variant type
  • de sanctis-cacchione syndrome
xeroderma pigmentosum, group c
  • xeroderma pigmentosum, type 3
- elite association - COSMIC cancer census association via MalaCards
Search CETN2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CETN2

Genetic Association Database (GAD)
CETN2
Human Genome Epidemiology (HuGE) Navigator
CETN2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CETN2
genes like me logo Genes that share disorders with CETN2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CETN2 Gene

Publications for CETN2 Gene

  1. Centrin 2 stimulates nucleotide excision repair by interacting with xeroderma pigmentosum group C protein. (PMID: 15964821) Nishi R. … Hanaoka F. (Mol. Cell. Biol. 2005) 3 4 23 67
  2. Refined mapping of caltractin in human Xq28 and in the homologous region of the mouse X chromosome places the gene within the bare patches (Bpa) and striated (Str) critical regions. (PMID: 8597638) Chatterjee A. … Herman G.E. (Mamm. Genome 1995) 2 3 23
  3. Assignment of the human caltractin gene (CALT) to Xq28 by fluorescence in situ hybridization. (PMID: 7713520) Tanaka T. … Nakamura Y. (Genomics 1994) 2 3 23
  4. Structure, dynamics and thermodynamics of the human centrin 2/hSfi1 complex. (PMID: 19857500) Martinez-Sanz J. … Craescu C.T. (J. Mol. Biol. 2010) 3 23
  5. SUMO-dependent regulation of centrin-2. (PMID: 19706679) Klein U.R. … Nigg E.A. (J. Cell. Sci. 2009) 3 23

Products for CETN2 Gene

Sources for CETN2 Gene

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