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Aliases for CETN1 Gene

Aliases for CETN1 Gene

  • Centrin, EF-Hand Protein, 1 2 3
  • CEN1 3 4 6
  • CETN 3 4
  • Calcium Binding Protein 3
  • Caltractin Isoform 2 4
  • EF-Hand Protein 3
  • Caltractin 3
  • Centrin-1 3

External Ids for CETN1 Gene

Previous HGNC Symbols for CETN1 Gene

  • CETN

Previous GeneCards Identifiers for CETN1 Gene

  • GC18P000864
  • GC18P000567

Summaries for CETN1 Gene

Entrez Gene Summary for CETN1 Gene

  • The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle. [provided by RefSeq, Jan 2015]

GeneCards Summary for CETN1 Gene

CETN1 (Centrin, EF-Hand Protein, 1) is a Protein Coding gene. GO annotations related to this gene include calcium ion binding and microtubule binding. An important paralog of this gene is CETN2.

UniProtKB/Swiss-Prot for CETN1 Gene

  • Plays a fundamental role in microtubule-organizing center structure and function

Gene Wiki entry for CETN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CETN1 Gene

Genomics for CETN1 Gene

Regulatory Elements for CETN1 Gene

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CETN1 Gene

Start:
580,357 bp from pter
End:
582,114 bp from pter
Size:
1,758 bases
Orientation:
Plus strand

Genomic View for CETN1 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CETN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CETN1 Gene

Proteins for CETN1 Gene

  • Protein details for CETN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12798-CETN1_HUMAN
    Recommended name:
    Centrin-1
    Protein Accession:
    Q12798
    Secondary Accessions:
    • B2R536

    Protein attributes for CETN1 Gene

    Size:
    172 amino acids
    Molecular mass:
    19570 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with PIFO.
    Miscellaneous:
    • Binds two moles of calcium per mole of protein

neXtProt entry for CETN1 Gene

Proteomics data for CETN1 Gene at MOPED

Post-translational modifications for CETN1 Gene

  • Ubiquitination at Lys120 and Lys124
  • Modification sites at PhosphoSitePlus

Other Protein References for CETN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CETN1 Gene

Domains for CETN1 Gene

Gene Families for CETN1 Gene

HGNC:
  • EFHAND :EF-hand domain containing

Protein Domains for CETN1 Gene

Suggested Antigen Peptide Sequences for CETN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12798

UniProtKB/Swiss-Prot:

CETN1_HUMAN :
  • Q12798
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the centrin family.
genes like me logo Genes that share domains with CETN1: view

Function for CETN1 Gene

Molecular function for CETN1 Gene

UniProtKB/Swiss-Prot Function: Plays a fundamental role in microtubule-organizing center structure and function

Gene Ontology (GO) - Molecular Function for CETN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0003676 nucleic acid binding --
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 20643351
GO:0005524 ATP binding --
GO:0008017 microtubule binding IEA --
genes like me logo Genes that share ontologies with CETN1: view

Animal Model Products

miRNA for CETN1 Gene

miRTarBase miRNAs that target CETN1

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CETN1

In Situ Assay Products

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CETN1 Gene

Localization for CETN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CETN1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Centrosome of interphase and mitotic cells.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CETN1 Gene COMPARTMENTS Subcellular localization image for CETN1 gene
Compartment Confidence
cytoskeleton 5
cytosol 3
nucleus 3

Gene Ontology (GO) - Cellular Components for CETN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 8175926
GO:0005813 centrosome IMP 18331714
GO:0005814 centriole IDA 18331714
GO:0032391 photoreceptor connecting cilium IEA --
genes like me logo Genes that share ontologies with CETN1: view

Pathways for CETN1 Gene

SuperPathways for CETN1 Gene

No Data Available

Gene Ontology (GO) - Biological Process for CETN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006200 obsolete ATP catabolic process --
GO:0007067 mitotic nuclear division IEA --
GO:0034605 cellular response to heat IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CETN1: view

No data available for Pathways by source for CETN1 Gene

Compounds for CETN1 Gene

(1) HMDB Compounds for CETN1 Gene

Compound Synonyms Cas Number PubMed IDs
Calcium
  • Ca
7440-70-2
genes like me logo Genes that share compounds with CETN1: view

Transcripts for CETN1 Gene

mRNA/cDNA for CETN1 Gene

(24) Selected AceView cDNA sequences:
(3) Additional mRNA sequences :
(1) REFSEQ mRNAs :
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CETN1 Gene

Centrin, EF-hand protein, 1:
Representative Sequences:

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CETN1

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CETN1 Gene

No ASD Table

Relevant External Links for CETN1 Gene

GeneLoc Exon Structure for
CETN1
ECgene alternative splicing isoforms for
CETN1

Expression for CETN1 Gene

mRNA expression in normal human tissues for CETN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CETN1 Gene

This gene is overexpressed in Testis (52.7).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, and MOPED for CETN1 Gene

SOURCE GeneReport for Unigene cluster for CETN1 Gene Hs.122511

genes like me logo Genes that share expressions with CETN1: view

In Situ Assay Products

No data available for mRNA Expression by UniProt/SwissProt for CETN1 Gene

Orthologs for CETN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CETN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CETN1 35
  • 97.67 (n)
  • 97.09 (a)
CETN1 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CETN1 35
  • 87.02 (n)
  • 89.53 (a)
CETN1 36
  • 90 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CETN1 35
  • 87.79 (n)
  • 93.02 (a)
CETN1 36
  • 93 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Cetn1 35
  • 85.08 (n)
  • 90.7 (a)
Cetn1 16
Cetn1 36
  • 91 (a)
OneToOne
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 85 (a)
ManyToMany
platypus
(Ornithorhynchus anatinus)
Mammalia -- 36
  • 78 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cetn1 35
  • 84.3 (n)
  • 90.12 (a)
chicken
(Gallus gallus)
Aves CETN1 35
  • 67.84 (n)
  • 81.29 (a)
CETN2 36
  • 84 (a)
OneToOne
lizard
(Anolis carolinensis)
Reptilia CETN1 36
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cetn2 35
  • 74.27 (n)
  • 81.87 (a)
cetn2 36
  • 80 (a)
OneToMany
fruit fly
(Drosophila melanogaster)
Insecta CG17493 36
  • 65 (a)
ManyToMany
CG31802 36
  • 53 (a)
ManyToMany
CG17493 37
  • 71 (a)
worm
(Caenorhabditis elegans)
Secernentea R08D7.5 36
  • 34 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC31 36
  • 52 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CEN2 35
  • 57.63 (n)
  • 52.26 (a)
barley
(Hordeum vulgare)
Liliopsida Hv.7959 35
rice
(Oryza sativa)
Liliopsida Os10g0389000 35
  • 63.14 (n)
  • 50.59 (a)
sea squirt
(Ciona savignyi)
Ascidiacea -- 36
  • 31 (a)
ManyToMany
Species with no ortholog for CETN1:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CETN1 Gene

ENSEMBL:
Gene Tree for CETN1 (if available)
TreeFam:
Gene Tree for CETN1 (if available)

Paralogs for CETN1 Gene

Paralogs for CETN1 Gene

Selected SIMAP similar genes for CETN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CETN1: view

Variants for CETN1 Gene

Sequence variations from dbSNP and Humsavar for CETN1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type MAF
rs500379 -- 578,429(-) TGTTT(C/T)TTAAA upstream-variant-2KB
rs1056234 -- 581,954(+) AACTG(C/T)TCCAC downstream-variant-500B
rs2298580 -- 582,022(-) ATCTT(A/G)CTCCA downstream-variant-500B
rs3016817 -- 579,758(-) AAGCC(G/T)GGCCT upstream-variant-2KB
rs3016818 -- 579,716(-) GTTCT(A/G)GCGGC upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CETN1 Gene

Variant ID Type Subtype PubMed ID
nsv909287 CNV Gain 21882294
nsv909288 CNV Loss 21882294
nsv909289 CNV Loss 21882294
nsv833577 CNV Gain+Loss 17160897
nsv909292 CNV Gain 21882294
nsv528169 CNV Loss 19592680
nsv909293 CNV Loss 21882294

Relevant External Links for CETN1 Gene

HapMap Linkage Disequilibrium report
CETN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CETN1 Gene

Disorders for CETN1 Gene

No disorders were found for CETN1 Gene.

No data available for UniProtKB/Swiss-Prot for CETN1 Gene

Publications for CETN1 Gene

  1. Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles. (PMID: 8175926) Errabolu R. … Salisbury J.L. (J. Cell Sci. 1994) 2 3 4
  2. Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro. (PMID: 10725219) Laoukili J. … Tournier F. (J. Cell. Sci. 2000) 3 23
  3. Pitchfork regulates primary cilia disassembly and left-right asymmetry. (PMID: 20643351) Kinzel D. … Lickert H. (Dev. Cell 2010) 3 4
  4. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4
  5. A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry. (PMID: 15514162) Matsumoto Y. … Maller J.L. (Science 2004) 3

Products for CETN1 Gene

Sources for CETN1 Gene

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