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Aliases for CETN1 Gene

Aliases for CETN1 Gene

  • Centrin 1 2 3 5
  • Centrin, EF-Hand Protein, 1 2 3
  • CETN 3 4
  • CEN1 3 4
  • Testicular Tissue Protein Li 37 3
  • Calcium Binding Protein 3
  • Caltractin Isoform 2 4
  • EF-Hand Protein 3
  • Caltractin 3
  • Centrin-1 3

External Ids for CETN1 Gene

Previous HGNC Symbols for CETN1 Gene

  • CETN

Previous GeneCards Identifiers for CETN1 Gene

  • GC18P000864
  • GC18P000567

Summaries for CETN1 Gene

Entrez Gene Summary for CETN1 Gene

  • The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, and in the process of microtubule severing. This protein is localized to the centrosome of interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosome during the cell cycle. [provided by RefSeq, Jan 2015]

GeneCards Summary for CETN1 Gene

CETN1 (Centrin 1) is a Protein Coding gene. GO annotations related to this gene include nucleic acid binding and microtubule binding. An important paralog of this gene is CETN2.

UniProtKB/Swiss-Prot for CETN1 Gene

  • Plays a fundamental role in microtubule-organizing center structure and function.

Gene Wiki entry for CETN1 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CETN1 Gene

Genomics for CETN1 Gene

Regulatory Elements for CETN1 Gene

Enhancers for CETN1 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH18F000157 1.5 FANTOM5 ENCODE 38.8 -421.4 -421391 2.3 HDGF PKNOX1 ARNT MLX CREB3L1 WRNIP1 ZFP64 ARID4B SIN3A DMAP1 CETN1 ROCK1P1 USP14 GC18M000160
GH18F000322 1.7 FANTOM5 Ensembl ENCODE 10.5 -257.4 -257380 1.7 ATF1 ARNT CREB3L1 ARID4B ZNF48 FOS JUNB NCOA1 REST NFIL3 THOC1 ENSG00000264514 CETN1 CLUL1 GC18P000404
GH18F000392 1.5 FANTOM5 Ensembl ENCODE 10.6 -185.4 -185435 4.8 PKNOX1 SIN3A FEZF1 ZNF2 GLIS2 FOS SP3 TSHZ1 REST ZNF488 THOC1 LINC01925 RN7SKP146 IL9RP4 LOC105371950 ENSG00000265671 LOC105371953 SLC25A3P3 ENSG00000263396 COLEC12
GH18F000518 1.2 Ensembl ENCODE 11.3 -61.3 -61301 2.0 ATF1 PKNOX1 ZNF766 GATA2 CREB3 MEF2D SMARCA4 PBX2 NBN LEF1 THOC1 CETN1 GC18M000518 COLEC12
GH18F000360 1.2 Ensembl ENCODE 10.4 -217.3 -217255 4.8 MLX ARID4B SIN3A FEZF1 ZNF48 ZNF2 KLF7 REST TSHZ1 ZNF488 COLEC12 CETN1 GC18P000404 ENSG00000264514
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CETN1 on UCSC Golden Path with GeneCards custom track

Genomic Location for CETN1 Gene

Chromosome:
18
Start:
580,343 bp from pter
End:
582,114 bp from pter
Size:
1,772 bases
Orientation:
Plus strand

Genomic View for CETN1 Gene

Genes around CETN1 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CETN1 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CETN1 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CETN1 Gene

Proteins for CETN1 Gene

  • Protein details for CETN1 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q12798-CETN1_HUMAN
    Recommended name:
    Centrin-1
    Protein Accession:
    Q12798
    Secondary Accessions:
    • B2R536

    Protein attributes for CETN1 Gene

    Size:
    172 amino acids
    Molecular mass:
    19570 Da
    Quaternary structure:
    • Monomer (By similarity). Interacts with PIFO.
    Miscellaneous:
    • Binds two moles of calcium per mole of protein.

neXtProt entry for CETN1 Gene

Post-translational modifications for CETN1 Gene

  • Modification sites at PhosphoSitePlus
  • Modification sites at neXtProt

Other Protein References for CETN1 Gene

ENSEMBL proteins:
REFSEQ proteins:

No data available for DME Specific Peptides for CETN1 Gene

Domains & Families for CETN1 Gene

Gene Families for CETN1 Gene

Suggested Antigen Peptide Sequences for CETN1 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q12798

UniProtKB/Swiss-Prot:

CETN1_HUMAN :
  • Contains 4 EF-hand domains.
  • Belongs to the centrin family.
Domain:
  • Contains 4 EF-hand domains.
Family:
  • Belongs to the centrin family.
genes like me logo Genes that share domains with CETN1: view

Function for CETN1 Gene

Molecular function for CETN1 Gene

UniProtKB/Swiss-Prot Function:
Plays a fundamental role in microtubule-organizing center structure and function.

Gene Ontology (GO) - Molecular Function for CETN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005509 calcium ion binding IEA --
GO:0005515 protein binding IPI 20643351
GO:0008017 microtubule binding IEA --
GO:0031683 G-protein beta/gamma-subunit complex binding IEA --
GO:0032795 heterotrimeric G-protein binding IEA --
genes like me logo Genes that share ontologies with CETN1: view
genes like me logo Genes that share phenotypes with CETN1: view

Animal Model Products

miRNA for CETN1 Gene

miRTarBase miRNAs that target CETN1

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CETN1

Flow Cytometry Products

No data available for Enzyme Numbers (IUBMB) , Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CETN1 Gene

Localization for CETN1 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CETN1 Gene

Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Centrosome of interphase and mitotic cells.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CETN1 gene
Compartment Confidence
cytoskeleton 5
nucleus 4
cytosol 3

Gene Ontology (GO) - Cellular Components for CETN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0000922 spindle pole IDA 8175926
GO:0005737 cytoplasm IEA --
GO:0005813 centrosome IMP,IDA 18331714
GO:0005814 centriole IDA 18331714
GO:0005815 microtubule organizing center IEA --
genes like me logo Genes that share ontologies with CETN1: view

Pathways & Interactions for CETN1 Gene

SuperPathways for CETN1 Gene

No Data Available

SIGNOR curated interactions for CETN1 Gene

Is activated by:

Gene Ontology (GO) - Biological Process for CETN1 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0007049 cell cycle IEA --
GO:0007067 mitotic nuclear division IEA --
GO:0034605 cellular response to heat IEA --
GO:0051301 cell division IEA --
genes like me logo Genes that share ontologies with CETN1: view

No data available for Pathways by source for CETN1 Gene

Drugs & Compounds for CETN1 Gene

(1) Drugs for CETN1 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
calcium Nutra 0
genes like me logo Genes that share compounds with CETN1: view

Transcripts for CETN1 Gene

mRNA/cDNA for CETN1 Gene

(1) REFSEQ mRNAs :
(3) Additional mRNA sequences :
(24) Selected AceView cDNA sequences:
(1) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CETN1 Gene

Centrin, EF-hand protein, 1:
Representative Sequences:

Inhibitory RNA Products

Clone Products

  • Addgene plasmids for CETN1

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CETN1 Gene

No ASD Table

Relevant External Links for CETN1 Gene

GeneLoc Exon Structure for
CETN1
ECgene alternative splicing isoforms for
CETN1

Expression for CETN1 Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and SAGE for CETN1 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CETN1 Gene

This gene is overexpressed in Testis (x52.7).

Protein differential expression in normal tissues from HIPED for CETN1 Gene

This gene is overexpressed in Brain (44.2), Peripheral blood mononuclear cells (12.4), and Ovary (12.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CETN1 Gene



Protein tissue co-expression partners for CETN1 Gene

NURSA nuclear receptor signaling pathways regulating expression of CETN1 Gene:

CETN1

SOURCE GeneReport for Unigene cluster for CETN1 Gene:

Hs.122511
genes like me logo Genes that share expression patterns with CETN1: view

No data available for mRNA Expression by UniProt/SwissProt for CETN1 Gene

Orthologs for CETN1 Gene

This gene was present in the common ancestor of eukaryotes.

Orthologs for CETN1 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CETN1 34 35
  • 97.67 (n)
dog
(Canis familiaris)
Mammalia CETN1 34 35
  • 87.79 (n)
cow
(Bos Taurus)
Mammalia CETN1 34 35
  • 87.02 (n)
mouse
(Mus musculus)
Mammalia Cetn1 34 16 35
  • 85.08 (n)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 85 (a)
ManyToMany
rat
(Rattus norvegicus)
Mammalia Cetn1 34
  • 84.3 (n)
platypus
(Ornithorhynchus anatinus)
Mammalia -- 35
  • 78 (a)
ManyToMany
chicken
(Gallus gallus)
Aves CETN2 35
  • 84 (a)
OneToOne
CETN1 34
  • 67.84 (n)
lizard
(Anolis carolinensis)
Reptilia CETN1 35
  • 78 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii cetn2 34 35
  • 74.27 (n)
fruit fly
(Drosophila melanogaster)
Insecta CG17493 36 35
  • 71 (a)
CG31802 35
  • 53 (a)
ManyToMany
worm
(Caenorhabditis elegans)
Secernentea R08D7.5 35
  • 34 (a)
ManyToMany
baker's yeast
(Saccharomyces cerevisiae)
Saccharomycetes CDC31 35
  • 52 (a)
OneToMany
thale cress
(Arabidopsis thaliana)
eudicotyledons CEN2 34
  • 57.63 (n)
rice
(Oryza sativa)
Liliopsida Os10g0389000 34
  • 63.14 (n)
barley
(Hordeum vulgare)
Liliopsida Hv.7959 34
sea squirt
(Ciona savignyi)
Ascidiacea -- 35
  • 31 (a)
ManyToMany
Species where no ortholog for CETN1 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CETN1 Gene

ENSEMBL:
Gene Tree for CETN1 (if available)
TreeFam:
Gene Tree for CETN1 (if available)

Paralogs for CETN1 Gene

Paralogs for CETN1 Gene

(27) SIMAP similar genes for CETN1 Gene using alignment to 1 proteins:

genes like me logo Genes that share paralogs with CETN1: view

Variants for CETN1 Gene

Sequence variations from dbSNP and Humsavar for CETN1 Gene

SNP ID Clin Chr 18 pos Sequence Context AA Info Type
rs1056234 -- 581,954(+) AACTG(C/T)TCCAC utr-variant-3-prime
rs111446891 -- 578,471(+) TTTTG(A/G)GGTTT upstream-variant-2KB
rs111457289 -- 581,369(+) CCTAG(C/G)CTGTC utr-variant-3-prime
rs112046549 -- 578,699(+) TTCCC(A/G)TGCCT upstream-variant-2KB
rs113168330 -- 579,229(+) AAGGC(A/G)ACCAG upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CETN1 Gene

Variant ID Type Subtype PubMed ID
nsv833577 CNV gain+loss 17160897
nsv576242 CNV gain 21841781
nsv576239 CNV gain 21841781
nsv576236 CNV gain 21841781
nsv576228 CNV loss 21841781
nsv528169 CNV loss 19592680
nsv482935 CNV loss 15286789
nsv1060188 CNV gain 25217958
esv3893055 CNV gain 25118596
esv3641497 CNV gain 21293372
esv3641496 CNV loss 21293372
dgv5810n54 CNV gain 21841781
dgv3307n100 CNV gain 25217958

Variation tolerance for CETN1 Gene

Residual Variation Intolerance Score: 46% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 6.02; 75.01% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CETN1 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CETN1

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CETN1 Gene

Disorders for CETN1 Gene

Relevant External Links for CETN1

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CETN1

No disorders were found for CETN1 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CETN1 Gene

Publications for CETN1 Gene

  1. Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles. (PMID: 8175926) Errabolu R. … Salisbury J.L. (J. Cell Sci. 1994) 2 3 4 64
  2. Pitchfork regulates primary cilia disassembly and left-right asymmetry. (PMID: 20643351) Kinzel D. … Lickert H. (Dev. Cell 2010) 3 4 64
  3. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PMID: 15489334) Gerhard D.S. … Malek J. (Genome Res. 2004) 3 4 64
  4. Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro. (PMID: 10725219) Laoukili J. … Tournier F. (J. Cell. Sci. 2000) 3 22 64
  5. A chirality change in XPC- and Sfi1-derived peptides affects their affinity for centrin. (PMID: 26923803) Grecu D. … Assairi L. (Peptides 2016) 3 64

Products for CETN1 Gene

Sources for CETN1 Gene

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