CETN1 Gene
protein-coding GIFtS: 56
GCID: GC18P000570
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centrin, EF-hand protein, 1
(Previous symbol: CETN)
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Aliases
for CETN1 gene
(According to
1HGNC,
2Entrez Gene,
3UniProtKB/Swiss-Prot,
4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc,
7Ensembl,
8DME,
9miRBase,
and/or 10fRNAdb)
About This Section
|
| Aliases |
|---|
| Centrin, EF-Hand Protein, 11 2 | | Caltractin1 | | CEN11 2 3 5 | | Centrin-11 | | CETN1 2 3 | | EF-Hand Protein2 | | Calcium Binding Protein2 | | Caltractin Isoform 23 |
Export aliases for CETN1 gene to outside databasesPrevious GC identifers: GC18P000864 GC18P000567 |
Summaries
for CETN1 gene(According to Entrez Gene,
Tocris Bioscience,
Wikipedia's
Gene Wiki,
PharmGKB,
UniProtKB/Swiss-Prot,
and/or
UniProtKB/TrEMBL)
About This Section
|
Entrez Gene summary for CETN1:
The protein encoded by this gene plays important roles in the determination of centrosome position and segregation, andin the process of microtubule severing. This encoded protein is localized to the centrosome of interphase cells, andredistributes to the region of the spindle poles during mitosis, reflecting the dynamic behavior of the centrosomeduring the cell cycle. (provided by RefSeq, Jul 2008)
UniProtKB/Swiss-Prot: CETN1_HUMAN, Q12798Function: Plays a fundamental role in microtubule-organizing center structure and function
Gene Wiki entry for CETN1
|
Genomic Views
for CETN1 gene
(According to
GeneLoc and/or
HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to
UCSC (hg19) and
Ensembl (release 69),
Regulatory elements and Epigenetics data according to
QIAGEN,
SABiosciences, and/or
SwitchGear Genomics)
About This Section
| RefSeq DNA sequence:- NC_000018.9 NC_018929.1 NT_010859.14
Regulatory elements:
 SABiosciences Regulatory transcription factor binding sites in the CETN1 gene promoter:
SRF Sp1 p53 Bach2 SRF (504 AA) PPAR-alpha FAC1 Pax-3 Ik-2 STAT3
Other transcription factors
Search SABiosciences Chromatin IP Primers for CETN1
Epigenetics:
| | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CETN1 |
Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track
Entrez Gene cytogenetic band: 18p11.32 Ensembl cytogenetic band: 18p11.32 HGNC cytogenetic band: 18p11.32CETN1 Gene in genomic location: bands according to Ensembl, locations according to
 (and/or Entrez Gene and/or Ensembl if different)
GeneLoc information about chromosome 18 GeneLoc Exon Structure GeneLoc location for GC18P000570: view genomic region
(about GC identifiers)
Start:
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580,367 bp from pter |
End:
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581,524 bp from pter |
Size:
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1,158 bases |
Orientation:
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plus strand |
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Proteins
for CETN1 gene
(According to
1UniProtKB,
HORDE,
neXtProt,
Ensembl,
and/or Reactome,
Modification sites according to 2PhosphoSitePlus,
Specific Peptides from DME,
Protein expression images according to data from SPIRE MOPED and PaxDb,
RefSeq according to NCBI,
PDB rendering according to OCA and/or Proteopedia,
Recombinant Proteins
from
EMD Millipore,
R&D Systems,
GenScript,
Enzo Life Sciences,
OriGene,
Novus Biologicals,
Sino Biological,
ProSpec, and/or
Uscn,
Biochemical Assays by
EMD Millipore,
R&D Systems,
OriGene,
GenScript,
Cell Signaling Technology,
Enzo Life Sciences, and/or
Uscn,
Ontologies according to Gene
Ontology Consortium 01 Mar 2013 and
Entrez Gene,
Antibodies by
EMD Millipore,
R&D Systems,
GenScript,
Cell Signaling Technology,
OriGene,
Novus Biologicals,
Thermo Fisher Scientific,
Abcam, and/or
Uscn)
About This Section
|
UniProtKB/Swiss-Prot: CETN1_HUMAN, Q12798 (See
protein sequence)Recommended Name: Centrin-1 Size: 172 amino acids; 19570 Da
Subunit: Monomer (By similarity). Interacts with PIFO
Subcellular location: Cytoplasm, cytoskeleton, centrosome. Note=Centrosome of interphase and mitotic cells
Miscellaneous: Binds two moles of calcium per mole of protein
Secondary accessions: B2R536Explore the universe of human proteins at neXtProt for CETN1: NX_Q12798
Post-translational modifications:
View modification sites using PhosphoSitePlus2View neXtProt modification sites for NX_Q12798
CETN1 Protein expression data from MOPED and PaxDb: About this image 
REFSEQ proteins: NP_004057.1
ENSEMBL proteins: ENSP00000319052
Human Recombinant Protein Products:
Gene Ontology (GO): 5 cellular component terms (GO ID links to tree view): About this table
CETN1 for ontologies About GeneDecksing
CETN1 Antibody Products:
Assay Products for CETN1: |
Protein
Domains /
Families
for CETN1 gene(According to InterPro, ProtoNet,
UniProtKB, and/or BLOCKS,
Sets of similar genes according to GeneDecks)
About This Section
|
CETN1 for domains About GeneDecksing
4 InterPro domains/families:Graphical View of Domain Structure for InterPro Entry Q12798ProtoNet protein and cluster: Q12798 UniProtKB/Swiss-Prot: CETN1_HUMAN, Q12798Similarity: Belongs to the centrin familySimilarity: Contains 4 EF-hand domains |
Function
for CETN1 gene
(According to 1UniProtKB,
Genatlas,
LifeMap Discovery™,
IUBMB, and/or
2DME,
Human phenotypes from GenomeRNAi,
Animal models from MGI Mar 06 2013,
bound targets from SABiosciences,
miRNA Gene Targets from miRTarBase
shRNA from
OriGene,
RNAi from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
microRNA from QIAGEN,
Gene Editing from DNA2.0,
Clones from EMD Millipore,
OriGene,
SwitchGear Genomics,
GenScript,
Sino Biological,
DNA2.0,
and Vector BioLabs,
Cell Lines from GenScript,
LifeMap BioReagents,
In Situ Hybridization Assays from Advanced Cell Diagnostics,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene.)
About This Section
|
Function Summary:
UniProtKB/Swiss-Prot: CETN1_HUMAN, Q12798Function: Plays a fundamental role in microtubule-organizing center structure and function
Clone
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OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CETN1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
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In Situ Assay
Products: |
 | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CETN1 |
Gene Ontology (GO): 5/8 molecular function terms (GO ID links to tree view) (see all 8): About this table
CETN1 for ontologies About GeneDecksing
|
Pathways & Interactions
for CETN1 gene
(Pathways according to
EMD Millipore,
R&D Systems,
Cell Signaling Technology,
KEGG,
PharmGKB,
BioSystems,
Reactome,
Tocris Bioscience,
GeneGo (Thomson Reuters),
QIAGEN,
and/or UniProtKB,
Sets of similar genes according to GeneDecks,
Interaction Networks according to
SABiosciences,
and/or STRING,
Interactions according to 1UniProtKB,
2MINT,
3I2D, and/or
4STRING,
with links to IntAct and
Ensembl,
Ontologies according to Gene Ontology Consortium 01 Mar 2013 via
Entrez Gene).
About This Section
|
Interactions:
Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CETN1
STRING Interaction
Network Preview (showing 5 interactants - click image to see more details)
5 Interacting proteins for CETN1 (Q127982, 3 ENSP000003190524) via UniProtKB, MINT, STRING, and/or I2DAbout this table
Gene Ontology (GO): 3 biological process terms (GO ID links to tree view): About this table
CETN1 for ontologies About GeneDecksing
|
Drugs & Compounds
for CETN1 gene(Chemical Compounds according to UniProtKB, Enzo Life Sciences,
EMD Millipore, Tocris Bioscience
HMDB,
BitterDB, and/or
Novoseek, and Drugs according to
DrugBank,
Enzo Life Sciences, and/or
PharmGKB, with drugs/clinical trials/news
search links to CenterWatch)
About This Section
|
 Browse Tocris compounds for CETN1
1 HMDB Compound for CETN1 About this table
Search CenterWatch for drugs/clinical trials and news about CETN1
|
Transcripts
for CETN1 gene(Secondary structures according to
fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene
(Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or
AceView,
transcript ids from Ensembl
with links to UCSC,
exon structure from GeneLoc,
alternative splicing isoforms according to ASD and/or
ECgene,
RNAi Products from
EMD Millipore,
siRNAs from
OriGene,
QIAGEN,
shRNA from
OriGene,
microRNA from QIAGEN,
Tagged/untagged cDNA clones from
OriGene,
SwitchGear Genomics,
GenScript,
DNA2.0,
Vector BioLabs,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN
)
About This Section
|
REFSEQ mRNAs for CETN1 gene: NM_004066.1 Unigene Cluster for CETN1: Centrin, EF-hand protein, 1 Hs.122511 [show with all ESTs]Unigene Representative Sequence: BC0295151 Ensembl transcript including schematic representation, and UCSC links where relevant: ENST00000327228(uc002kko.1)
Clone
Products: | | OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CETN1 (see all 2)
OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CETN1 (see all 2)
OriGene custom cloning services – gene synthesis, subcloning, mutagenesis,
variant library, vector shuttling
| | | GenScript: all cDNA clones in your preferred vector: CETN1 (NM_004066) | | | DNA2.0 Custom Codon Optimized Gene
Synthesis Service for CETN1 | | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CETN1 |
Additional cDNA sequence: AK312047.1 BC029515.1 U03270.1 1 DOTS entry: DT.108313 24 AceView cDNA sequences: CR590315 CR601265 BX090760 BX093850 BI826477 BI520329 BM560327 BC029515 BX360850 BV199021 AI198628 U03270 NM_004066 BI561765 T29817 AA778613 BX382179 AA421649 AI125275 AA470090 AA872034 BU854295 BP371095 BX370117
GeneLoc Exon Structure
|
Expression
for CETN1 gene
(RNA expression data according to
H-InvDB,
NONCODE,
miRBase, and
RNAdb,
Expression images according to data from
BioGPS,
Illumina Human BodyMap, and
CGAP
SAGE,
Sets of similar genes according to GeneDecks,
in vivo and in vitro expression data from LifeMap Discovery™,
plus additional links to
Genevestigator, and/or
SOURCE, and/or
BioGPS, and/or
UniProtKB,
PCR Arrays from
SABiosciences,
Primers from
OriGene,
SABiosciences, and/or
QIAGEN,
In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section
| CETN1 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: TGTAAATTGT
About this image
See CETN1 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CETN1
SOURCE GeneReport for Unigene cluster: Hs.122511
SABiosciences Custom PCR Arrays for CETN1
Primer
Products: | | OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CETN1
Browse OriGene validated miRNA SYBR primer pairs
| | | SABiosciences RT2 qPCR Primer Assay in human, mouse, rat CETN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CETN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CETN1 | In Situ
Assay Products: |
| Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CETN1 |
Orthologs
for CETN1 gene
(Orthologs according to
1,2HomoloGene (2older version, for species not in 1newer version),
3euGenes,
4SGD
,
5MGI Mar 06 2013,
with possible further links to
Flybase
and/or
WormBase,
and/or
6Ensembl pan taxonomic compara ,
Gene Trees according to Ensembl and
TreeFam)
About This Section
|
This gene was present in the common ancestor of eukaryotes.
Orthologs for CETN1 gene from 6/24 species (see all 24) About this table
ENSEMBL Gene Tree for CETN1 (if available)
TreeFam Gene Tree for CETN1 (if available) |
Paralogs
for CETN1 gene(Paralogs according to
1HomoloGene,
2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
About This Section
| Paralogs for CETN1 gene
- EFCAB22 CETN22 CETN32
18/29 SIMAP similar genes for CETN1 using alignment to 1 protein entry: CETN1_HUMAN(see all similar genes):CETN2 CALM3 CETN3 CALM2 CALM1 CALML3
TNNC1 TNNC2 EFCAB2 CALML5 CABP7 MYL1
HZGJ PPP3R1 PPP3R2 CABP4 CABP5 CALML4
CETN1 for paralogs About GeneDecksing
|
Genomic Variants
for CETN1 gene(SNPs/Variants according to the
1NCBI SNP Database,
2Ensembl,
3PupaSUITE,
UniProtKB, and
DNA2.0,
Linkage Disequilibrium by HapMap,
Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene
Mutation Database (HGMD) and the Locus Specific Mutation
Databases (LSDB), Blood group antigen gene mutations by BGMUT,
Resequencing Primers from QIAGEN,
Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section
|
| Genomic Data | Transcription Related Data | Allele Frequencies | | SNP ID | Valid | Clinical
significance | Chr 18 pos | Sequence | # | AA
Chg | Type | More | # | Allele
freq | Pop | Total
sample | More |
|---|
HapMap Linkage Disequilibrium report for CETN1 (580367 - 581524 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV): 1 variation for CETN1
1 CNV: 5044 | SABiosciences Cancer Mutation PCR Assays |
| | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CETN1 |
|
Disorders
/ Diseases
for CETN1 gene
(in which this Gene is Involved, According to MalaCards,
OMIM, UniProtKB,
the University of Copenhagen DISEASES
database,
Genatlas, GeneTests,
GAD,
HuGE Navigator,
and/or TGDB.)
About This Section
|
CETN1 for disorders About GeneDecksing
OMIM gene information: 603187
OMIM disorders: --
5  diseases for CETN1: About MalaCardspelvic inflammatory disease nasopharynx carcinoma usher syndrome malaria
carcinoma
1 disease from the University of Copenhagen DISEASES database for CETN1:Pelvic inflammatory disease Export disorders for CETN1 gene to outside databases
|
Publications
for CETN1 gene (in
PubMed.
Associations of this gene to articles via
1Entrez Gene,
2UniProtKB/Swiss-Prot,
3HGNC,
4GAD,
5PharmGKB,
6HMDB,
7DrugBank,
8UniProtKB/TrEMBL,
9 Novoseek, and/or
10fRNAdb)
About This Section
|
PubMed articles for CETN1 gene, integrated from 9 sources (see all 20):
(articles sorted by number of sources associating them with CETN1) | |  | Utopia: connect your pdf to the dynamic
world of online information |
- Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles. (PubMed id 8175926)1, 2, 3 Errabolu R.... Salisbury J.L. (1994)
- The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S....Malek J. (2004)
- Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro. (PubMed id 10725219)1, 9 Laoukili J....Tournier F. (2000)
- Pitchfork regulates primary cilia disassembly and lef t-right asymmetry. (PubMed id 20643351)2 Kinzel D....Lickert H. (2010)
- Defining the human deubiquitinating enzyme interactio n landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (2009)
- CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. (PubMed id 16760425)1 Tsang W.Y.... Dynlacht B.D. (2006)
- The GIT-associated kinase PAK targets to the centrosome and regulates Aurora-A. (PubMed id 16246726)1 Zhao Z.S....Manser E. (2005)
- HIV-1 Gag-RNA interaction occurs at a perinuclear/centrosomal site; analysis by confocal microscopy and FRET. (PubMed id 16101678)1 Poole E....Lever A.M. (2005)
- Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)2 Ota T.... Sugano S. (2004)
- A centrosomal localization signal in cyclin E required for Cdk2-independent S phase entry. (PubMed id 15514162)1 Matsumoto Y. and Maller J.L. (2004)
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External Searches for CETN1 gene
(in PubMed,
OMIM, and NCBI Bookshelf)
About This Section
|
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Genome Databases showing CETN1 gene
(According to
Entrez Gene,
HGNC,
AceView,
euGenes,
Ensembl,
miRBase,
ECgene,
Kegg,
and/or
H-InvDB)
About This Section
|
|
Other Databases showing CETN1 gene
(According to HUGE)
About This Section
| -- |
Specialized Databases showing CETN1 gene(According to PharmGKB,
ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
About This Section
|
|
About This Section
| Patent Information for CETN1 gene:
Search GeneIP for patents involving CETN1
GeneCards and IP:
Japan Patent Office Licenses GeneCards European Patent Office Licenses GeneCards Improving the IP Search
|
Products
for CETN1 gene(Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, SABiosciences, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Uscn, Thermo Fisher Scientific, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Cell lines from GenScript and LifeMap BioReagents, PCR Arrays from SABiosciences, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, and/or
Enzo Life Sciences),
In Situ Hybridization Assays from
Advanced Cell Diagnostics
About This Section
|
 | |
 | |
 |
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| | | QIAGEN Custom miScript Target Protector blocks miRNA-binding site of in human, mouse, rat CETN1 | | | QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CETN1 | | | QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CETN1 | | | QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CETN1 | | | QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CETN1 | | | QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CETN1 |
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| | | | Search Tocris compounds for CETN1 |
| |  |  |  |  | | | | | | Recombinant Protein for CETN1 |
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 | | | CETN1 Proteins, Antibodies, CLIAs, and ELISAs |
| | | | | Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CETN1 |
|  |  |  | | | | ThermoFisher Antibodies for CETN1 |
| | | Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CETN1 |
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