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CETN1 Gene

protein-coding   GIFtS: 56
GCID: GC18P000570

Centrin, EF-Hand Protein, 1


(Previous symbol: CETN)
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Centrin, EF-Hand Protein, 11 2     caltractin2
CETN1 2 3     centrin-12
CEN12 3 5     EF-Hand Protein2
Calcium Binding Protein2     Caltractin Isoform 23

External Ids:    HGNC: 18661   Entrez Gene: 10682   Ensembl: ENSG000001771437   OMIM: 6031875   UniProtKB: Q127983   

Export aliases for CETN1 gene to outside databases

Previous GC identifers: GC18P000864 GC18P000567


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CETN1 Gene:
The protein encoded by this gene plays important roles in the determination of centrosome position and
segregation, and in the process of microtubule severing. This encoded protein is localized to the centrosome of
interphase cells, and redistributes to the region of the spindle poles during mitosis, reflecting the dynamic
behavior of the centrosome during the cell cycle. (provided by RefSeq, Jul 2008)

GeneCards Summary for CETN1 Gene:
CETN1 (centrin, EF-hand protein, 1) is a protein-coding gene. Diseases associated with CETN1 include nasopharynx carcinoma, and pelvic inflammatory disease. GO annotations related to this gene include microtubule binding and calcium ion binding. An important paralog of this gene is EFCAB2.

UniProtKB/Swiss-Prot: CETN1_HUMAN, Q12798
Function: Plays a fundamental role in microtubule-organizing center structure and function

Gene Wiki entry for CETN1 Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000018.10  NC_018929.2  NT_010859.15  
Regulatory elements:
   Regulatory transcription factor binding sites in the CETN1 gene promoter:
         SRF   Sp1   p53   Bach2   SRF (504 AA)   PPAR-alpha   FAC1   Pax-3   Ik-2   STAT3   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmids (see all 2): CETN1 promoter sequence
   Search Chromatin IP Primers for CETN1

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CETN1


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 18p11.32   Ensembl cytogenetic band:  18p11.32   HGNC cytogenetic band: 18p11.32

CETN1 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CETN1 gene location

GeneLoc information about chromosome 18         GeneLoc Exon Structure

GeneLoc location for GC18P000570:  view genomic region     (about GC identifiers)

Start:
580,367 bp from pter      End:
581,524 bp from pter
Size:
1,158 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
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UniProtKB/Swiss-Prot: CETN1_HUMAN, Q12798 (See protein sequence)
Recommended Name: Centrin-1  
Size: 172 amino acids; 19570 Da
Subunit: Monomer (By similarity). Interacts with PIFO
Miscellaneous: Binds two moles of calcium per mole of protein
Secondary accessions: B2R536

Explore the universe of human proteins at neXtProt for CETN1: NX_Q12798

Explore proteomics data for CETN1 at MOPED

Post-translational modifications: 

  • Ubiquitination2 at Lys120, Lys124
  • Modification sites at PhosphoSitePlus

  • See CETN1 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins: NP_004057.1  
    ENSEMBL proteins: 
     ENSP00000319052  

    CETN1 Human Recombinant Protein Products:

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    Cloud-Clone Corp. CLIAs for CETN1


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    EFHAND: EF-hand domain containing

    4 InterPro protein domains:
     IPR000629 RNA-helicase_DEAD-box_CS
     IPR011992 EF-hand-dom_pair
     IPR002048 EF_hand_dom
     IPR018247 EF_Hand_1_Ca_BS

    Graphical View of Domain Structure for InterPro Entry Q12798

    ProtoNet protein and cluster: Q12798

    UniProtKB/Swiss-Prot: CETN1_HUMAN, Q12798
    Similarity: Belongs to the centrin family
    Similarity: Contains 4 EF-hand domains


    CETN1 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: CETN1_HUMAN, Q12798
    Function: Plays a fundamental role in microtubule-organizing center structure and function

         Gene Ontology (GO): Selected molecular function terms (see all 8):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0003676nucleic acid binding IEA--
    GO:0005509calcium ion binding IEA--
    GO:0005515protein binding IPI--
    GO:0005524ATP binding IEA--
    GO:0008017microtubule binding IEA--
         
    CETN1 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CETN1
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    miRNA
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    miRTarBase miRNAs that target CETN1:
    hsa-mir-128-3p (MIRT022033)

    Block miRNA regulation of human, mouse, rat CETN1 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CETN1:
    hsa-miR-580
    SwitchGear 3'UTR luciferase reporter plasmidCETN1 3' UTR sequence
    Inhib. RNA
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    Predesigned siRNA for gene silencing in human, mouse, rat CETN1

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    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    CETN1_HUMAN, Q12798: Cytoplasm, cytoskeleton, microtubule organizing center, centrosome. Note=Centrosome of
    interphase and mitotic cells
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    cytoskeleton5
    cytosol3
    nucleus3

    Gene Ontology (GO): 5 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0000922spindle pole IDA8175926
    GO:0005737cytoplasm ----
    GO:0005813centrosome IDA8175926
    GO:0005814centriole IEA--
    GO:0032391photoreceptor connecting cilium IEA--

    CETN1 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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        Custom Pathway & Disease-focused RT2 Profiler PCR Arrays for CETN1
    Interactions:

        Search GeneGlobe Interaction Network for CETN1

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CETN1 (Q127982, 3 ENSP000003190524) via UniProtKB, MINT, STRING, and/or I2D (see all 104)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    TBCCD1Q9NVR72, 3, ENSP000003416524MINT-7891162 I2D: score=1 STRING: ENSP00000341652
    USP49Q70CQ13, ENSP000002972294I2D: score=2 STRING: ENSP00000297229
    PRKACAP176123, ENSP000003095914I2D: score=1 STRING: ENSP00000309591
    CCNE1ENSP000002626434STRING: ENSP00000262643
    TTKENSP000002305104STRING: ENSP00000230510
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0007067mitosis IEA--
    GO:0034605cellular response to heat IEA--

    CETN1 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CETN1

    1 HMDB Compound for CETN1    About this table
    CompoundSynonyms CAS #PubMed Ids
    CalciumCa (see all 2)7440-70-2--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CETN1 gene: 
    NM_004066.1  

    Unigene Cluster for CETN1:

    Centrin, EF-hand protein, 1
    Hs.122511  [show with all ESTs]
    Unigene Representative Sequence: BC029515
    1 Ensembl transcript including schematic representation, and UCSC links where relevant:
    ENST00000327228(uc002kko.1)
    miRNA
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    1 qRT-PCR Assays for microRNA that regulate CETN1:
    hsa-miR-580
    SwitchGear 3'UTR luciferase reporter plasmidCETN1 3' UTR sequence
    Inhib. RNA
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      QuantiTect SYBR Green Assays in human, mouse, rat CETN1
      QuantiFast Probe-based Assays in human, mouse, rat CETN1

    Additional mRNA sequence: 

    AK312047.1 BC029515.1 U03270.1 

    1 DOTS entry:

    DT.108313 

    24 AceView cDNA sequences:

    BI826477 BX093850 CR601265 CR590315 BX090760 BX382179 T29817 BI520329 
    BV199021 BI561765 AI125275 AA421649 U03270 NM_004066 BC029515 AI198628 
    BX360850 BM560327 AA778613 AA872034 AA470090 BP371095 BU854295 BX370117 

    GeneLoc Exon Structure


    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CETN1 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: TGTAAATTGT
    CETN1 Expression
    About this image


    CETN1 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 2) fully expand
     
     Eye (Sensory Organs)
             Retina
     
     Testis (Reproductive System)
    CETN1 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CETN1 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.122511
        Custom PCR Arrays for CETN1
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    In Situ
    Assay Products:
     

     
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of eukaryotes.

    Orthologs for CETN1 gene from Selected species (see all 17)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Cetn11 , 5 centrin 11, 5 85.08(n)1
    90.7(a)1
      18 (4.91 cM)5
    263691  NM_007593.51  NP_031619.31 
     96184195 
    chicken
    (Gallus gallus)
    Aves CETN11 centrin, EF-hand protein, 1 67.84(n)
    81.29(a)
      422668  NM_001277920.1  NP_001264849.1 
    lizard
    (Anolis carolinensis)
    Reptilia CETN16
    centrin, EF-hand protein, 1
    78(a)
    1 ↔ 1
    GL343202.1(1696694-1705150)
    zebrafish
    (Danio rerio)
    Actinopterygii cetn21 centrin, EF-hand protein, 2 74.27(n)
    81.87(a)
      795310  XM_002667181.3  XP_002667227.2 
    fruit fly
    (Drosophila melanogaster)
    Insecta CG174933 calcium ion binding 71(a)     --
    worm
    (Caenorhabditis elegans)
    Secernentea R08D7.56
    Protein R08D7.5 (R08D7.5) mRNA, complete cds
    34(a)
    many ↔ many
    III(8974186-8975062) WBGene00011145
    baker's yeast
    (Saccharomyces cerevisiae)
    Saccharomycetes CDC316
    Calcium-binding component of the spindle pole body...
    52(a)
    1 → many
    XV(811008-811493) YOR257W
    thale cress
    (Arabidopsis thaliana)
    eudicotyledons CEN21 CEN2 57.63(n)
    52.26(a)
      829855  NM_001036721.1  NP_001031798.1 
    rice
    (Oryza sativa)
    Liliopsida Os10g03890001 Os10g0389000 63.14(n)
    50.59(a)
      4348517  NM_001071033.2  NP_001064498.2 


    ENSEMBL Gene Tree for CETN1 (if available)
    TreeFam Gene Tree for CETN1 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CETN1 gene
    EFCAB22  CETN22  CETN32  
    Selected SIMAP similar genes for CETN1 using alignment to 1 protein entry:     CETN1_HUMAN(see all similar genes):
    CETN2    CALM2    CETN3    CALM1    CALML3    CALM3
    TNNC1    TNNC2    EFCAB2    CALML5    CABP7    MYL1
    HZGJ    PPP3R1    PPP3R2    CABP4    CABP5    CALML4

    CETN1 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CETN1 (see all 113)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 18 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs5003791,2
    C,F,A,H--570459(-) TGTTTT/CTTAAA 1 -- int18Minor allele frequency- C:0.24MN WA NA CSA 433
    rs1114468911,2
    C,F--570501(+) TTTTGG/AGGTTT 1 -- int12Minor allele frequency- A:0.15CSA WA 120
    rs80950321,2
    C,F,A--570509(+) TTTTCA/GCTTGT 1 -- int115Minor allele frequency- G:0.39NA EA WA CSA 736
    rs1879588631,2
    --570627(+) TTGTTC/TGTTTT 1 -- int10--------
    rs1928174411,2
    --570656(+) CTCTGC/TTGCCT 1 -- int10--------
    rs118773651,2
    C,F,H--570698(+) actgcC/Aacctc 1 -- int11Minor allele frequency- A:0.50NA 4
    rs1838349681,2
    --570705(+) CCTCCA/GCCTCC 1 -- int10--------
    rs1509964511,2
    --570791(+) TTTTCA/GTATTT 1 -- int10--------
    rs1420547561,2
    --570793(+) TTCGTA/GTTTTT 1 -- int10--------
    rs1881597051,2
    --570830(+) GCCAGA/GCTGGT 1 -- int10--------

    HapMap Linkage Disequilibrium report for CETN1 (580367 - 581524 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 7 variations for CETN1:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv909289CNV Loss21882294
    nsv528169CNV Loss19592680
    nsv909293CNV Loss21882294
    nsv909288CNV Loss21882294
    nsv909292CNV Gain21882294
    nsv909287CNV Gain21882294
    nsv833577CNV Gain+Loss17160897

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CETN1
    DNA2.0 Custom Variant and Variant Library Synthesis for CETN1

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 603187    OMIM disorders: --

    8 diseases for CETN1:    
    About MalaCards
    nasopharynx carcinoma    pelvic inflammatory disease    usher syndrome    tonsillitis
    hiv-1    cerebritis    retinitis    thyroiditis


    CETN1 for disorders           About GeneDecksing


    Export disorders for CETN1 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CETN1 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with CETN1)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Cloning of a cDNA encoding human centrin, an EF-hand protein of centrosomes and mitotic spindle poles. (PubMed id 8175926)1, 2, 3 Errabolu R.... Salisbury J.L. (J. Cell Sci. 1994)
    2. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)1, 2 Gerhard D.S.... Malek J. (Genome Res. 2004)
    3. Differential expression and cellular distribution of centrin isoforms during human ciliated cell differentiation in vitro. (PubMed id 10725219)1, 9 Laoukili J....Tournier F. (J. Cell. Sci. 2000)
    4. Poly(ADP-ribose) polymerase-1 modulates Nrf2-dependent transcription. (PubMed id 24140708)1 Wu T....Zhang D.D. (amp 2014)
    5. Systems-wide analysis of ubiquitylation dynamics reveals a key role for PAF15 ubiquitylation in DNA-damage bypass. (PubMed id 23000965)1 Povlsen L.K....Choudhary C. (Nat. Cell Biol. 2012)
    6. Analysis of centrosome localization of BRCA1 and its activity in suppressing centrosomal aster formation. (PubMed id 22833046)1 Tarapore P....Fukasawa K. (Cell Cycle 2012)
    7. A proteome-wide, quantitative survey of in vivo ubiquitylation sites reveals widespread regulatory roles. (PubMed id 21890473)1 Wagner S.A....Choudhary C. (amp 2011)
    8. Pitchfork regulates primary cilia disassembly and left-right asymmetry. (PubMed id 20643351)2 Kinzel D.... Lickert H. (Dev. Cell 2010)
    9. Defining the human deubiquitinating enzyme interaction landscape. (PubMed id 19615732)1 Sowa M.E....Harper J.W. (Cell 2009)
    10. CP110 cooperates with two calcium-binding proteins to regulate cytokinesis and genome stability. (PubMed id 16760425)1 Tsang W.Y.... Dynlacht B.D. (Mol. Biol. Cell 2006)

    (in PubMed, OMIM, and NCBI Bookshelf)
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 1068 HGNC: 1866 AceView: CETN1 Ensembl:ENSG00000177143 euGenes: HUgn1068
    ECgene: CETN1 H-InvDB: CETN1

    (According to HUGE)
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    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CETN1 Pharmacogenomics, SNPs, Pathways
    ATLAS Chromosomes in Cancer entry for CETN1 Genetics and Cytogenetics in Oncology and Haematology

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CETN1 gene:
    Search GeneIP for patents involving CETN1

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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