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Aliases for CES5A Gene

Aliases for CES5A Gene

  • Carboxylesterase 5A 2 3 5
  • Carboxylesterase-Like Urinary Excreted Protein Homolog 3 4
  • Carboxylesterase 7 2 3
  • CAUXIN 3 4
  • CES7 3 4
  • Epididymis Luminal Protein 126 3
  • Carboxylesterase 5 3
  • EC 4
  • CES4C1 3
  • HEL126 3
  • CES5 3

External Ids for CES5A Gene

Previous HGNC Symbols for CES5A Gene

  • CES7

Summaries for CES5A Gene

Entrez Gene Summary for CES5A Gene

  • This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES5, is predominantly expressed in peripheral tissues, including brain, kidney, lung and testis. It encodes a secreted enzyme. Because of high levels in the urine of male domestic cats, this enzyme is also called cauxin (carboxylesterase-like urinary excreted protein). The enzyme functions in regulating the production of a pheromone precursor and may contribute to lipid and cholesterol transfer processes within male reproductive fluids. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jun 2010]

GeneCards Summary for CES5A Gene

CES5A (Carboxylesterase 5A) is a Protein Coding gene. Among its related pathways are Phase I, non P450 and E2F transcription factor network. GO annotations related to this gene include hydrolase activity and carboxylic ester hydrolase activity. An important paralog of this gene is CES2.

UniProtKB/Swiss-Prot for CES5A Gene

  • Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CES5A Gene

Genomics for CES5A Gene

Regulatory Elements for CES5A Gene

Enhancers for CES5A Gene
GeneHancer Identifier Score Enhancer Sources TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Other Gene Targets for Enhancer

Enhancers around CES5A on UCSC Golden Path with GeneCards custom track

Genomic Location for CES5A Gene

55,846,154 bp from pter
55,956,031 bp from pter
109,878 bases
Minus strand

Genomic View for CES5A Gene

Genes around CES5A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CES5A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CES5A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CES5A Gene

Proteins for CES5A Gene

  • Protein details for CES5A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carboxylesterase 5A
    Protein Accession:
    Secondary Accessions:
    • B7Z252
    • B7ZLB6
    • Q8NBC8
    • Q96DN9

    Protein attributes for CES5A Gene

    575 amino acids
    Molecular mass:
    63926 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CES5A Gene


neXtProt entry for CES5A Gene

Proteomics data for CES5A Gene at MOPED

Post-translational modifications for CES5A Gene

Antibody Products

  • Cloud-Clone Corp. Antibodies for CES5A
  • Santa Cruz Biotechnology (SCBT) Antibodies for CES5A

No data available for DME Specific Peptides for CES5A Gene

Domains & Families for CES5A Gene

Gene Families for CES5A Gene

Protein Domains for CES5A Gene

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the type-B carboxylesterase/lipase family.
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with CES5A: view

Function for CES5A Gene

Molecular function for CES5A Gene

UniProtKB/Swiss-Prot CatalyticActivity:
A carboxylic ester + H(2)O = an alcohol + a carboxylate.
UniProtKB/Swiss-Prot Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs.

Enzyme Numbers (IUBMB) for CES5A Gene

genes like me logo Genes that share phenotypes with CES5A: view

Animal Model Products

CRISPR Products

No data available for Gene Ontology (GO) - Molecular Function , Human Phenotype Ontology , Animal Models , miRNA , Transcription Factor Targets and HOMER Transcription for CES5A Gene

Localization for CES5A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CES5A Gene


Subcellular locations from

Jensen Localization Image for CES5A Gene COMPARTMENTS Subcellular localization image for CES5A gene
Compartment Confidence
extracellular 4
endoplasmic reticulum 3
plasma membrane 2
cytosol 1
lysosome 1
mitochondrion 1
peroxisome 1

No data available for Gene Ontology (GO) - Cellular Components for CES5A Gene

Pathways & Interactions for CES5A Gene

genes like me logo Genes that share pathways with CES5A: view

Pathways by source for CES5A Gene

Interacting Proteins for CES5A Gene

Gene Ontology (GO) - Biological Process for CES5A Gene


No data available for SIGNOR curated interactions for CES5A Gene

Drugs & Compounds for CES5A Gene

(9) Drugs for CES5A Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
1-Butanol Experimental Pharma 0
1-Proponol Experimental Pharma 0
Benzoic Acid Experimental Pharma 7
Ecgonine methyl ester Experimental Pharma 0
MYRISTIC ACID Experimental Pharma 0

(10) Additional Compounds for CES5A Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
  • 1-Hexanol
  • 1-Hexyl alcohol
  • 1-Hydroxyhexane
  • Alcohol C-6
  • Alcohol(C6)
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
carbon dioxide
  • Carbon oxide
  • Carbon-12 dioxide
  • Carbonic acid anhydride
  • Carbonic acid gas
  • Carbonic anhydride
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
genes like me logo Genes that share compounds with CES5A: view

Transcripts for CES5A Gene

mRNA/cDNA for CES5A Gene

(3) REFSEQ mRNAs :
(7) Additional mRNA sequences :
(10) Selected AceView cDNA sequences:
(9) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CES5A Gene

Carboxylesterase 5A:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CES5A Gene

ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
SP1: - -
SP2: - - -
SP3: -
SP4: -

Relevant External Links for CES5A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CES5A Gene

mRNA expression in normal human tissues for CES5A Gene

mRNA differential expression in normal tissues according to GTEx for CES5A Gene

This gene is overexpressed in Liver (x16.7) and Brain - Spinal cord (cervical c-1) (x4.5).

Protein differential expression in normal tissues from HIPED for CES5A Gene

This gene is overexpressed in Urine (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CES5A Gene

SOURCE GeneReport for Unigene cluster for CES5A Gene Hs.350800

genes like me logo Genes that share expression patterns with CES5A: view

Protein tissue co-expression partners for CES5A Gene

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CES5A Gene

Orthologs for CES5A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CES5A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CES5A 35
  • 81.4 (n)
  • 75.94 (a)
CES5A 36
  • 73 (a)
(Canis familiaris)
Mammalia CES5A 35
  • 83.27 (n)
  • 77.09 (a)
CES5A 36
  • 73 (a)
(Mus musculus)
Mammalia Ces5a 35
  • 77.28 (n)
  • 70.71 (a)
Ces5a 16
Ces5a 36
  • 69 (a)
(Pan troglodytes)
Mammalia CES5A 35
  • 98.61 (n)
  • 98.26 (a)
CES5A 36
  • 96 (a)
(Rattus norvegicus)
Mammalia Ces5a 35
  • 77.58 (n)
  • 71.43 (a)
(Anolis carolinensis)
Reptilia -- 36
  • 45 (a)
-- 36
  • 45 (a)
-- 36
  • 46 (a)
-- 36
  • 46 (a)
-- 36
  • 39 (a)
(Danio rerio)
Actinopterygii ces2 36
  • 42 (a)
ces3 36
  • 41 (a)
si:ch211-93f2.1 36
  • 14 (a)
Species with no ortholog for CES5A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • oppossum (Monodelphis domestica)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CES5A Gene

Gene Tree for CES5A (if available)
Gene Tree for CES5A (if available)

Paralogs for CES5A Gene

Paralogs for CES5A Gene

(13) SIMAP similar genes for CES5A Gene using alignment to 5 proteins: Pseudogenes for CES5A Gene

genes like me logo Genes that share paralogs with CES5A: view

Variants for CES5A Gene

Sequence variations from dbSNP and Humsavar for CES5A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_036836 -
VAR_036837 -
VAR_036838 -
VAR_036839 -
VAR_036840 -

Structural Variations from Database of Genomic Variants (DGV) for CES5A Gene

Variant ID Type Subtype PubMed ID
dgv892e1 CNV Complex 17122850
nsv7284 OTHER Inversion 18451855
dgv2865n71 CNV Gain 21882294
nsv833240 CNV Gain 17160897
nsv906713 CNV Gain 21882294
esv22088 CNV Gain 19812545
esv2714508 CNV Deletion 23290073
esv3683 CNV Deletion 18987735
nsv103512 CNV Loss 16902084
esv2274629 CNV Deletion 18987734

Variation tolerance for CES5A Gene

Residual Variation Intolerance Score: 97.1% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 15.31; 97.05% of all genes are more intolerant (likely to be disease-causing)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot and Relevant External Links for CES5A Gene

Disorders for CES5A Gene

Relevant External Links for CES5A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CES5A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CES5A Gene

Publications for CES5A Gene

  1. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. (PMID: 20931200) Holmes R.S. … Maltais L.J. (Mamm. Genome 2010) 2 3 67
  2. Mammalian carboxylesterase 5: comparative biochemistry and genomics. (PMID: 19727319) Holmes R.S. … Vandeberg J.L. (Comp. Biochem. Physiol. Part D Genomics Proteomics 2008) 3 23
  3. Molecular cloning and characterization of a novel carboxylesterase-like protein that is physiologically present at high concentrations in the urine of domestic cats (Felis catus). (PMID: 12401131) Miyazaki M. … Yamashita T. (Biochem. J. 2003) 3 23
  4. Genome wide association study (GWAS) of Chagas cardiomyopathy in Trypanosoma cruzi seropositive subjects. (PMID: 24324551) Deng X. … Seielstad M. (PLoS ONE 2013) 3
  5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PMID: 20379614) Rose J.E. … Uhl G.R. (Mol. Med. 2010) 3

Products for CES5A Gene

Sources for CES5A Gene