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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CES5A Gene

protein-coding   GIFtS: 49
GCID: GC16M055881

Carboxylesterase 5A

(Previous name: carboxylesterase 7)
(Previous symbol: CES7)
  See related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carboxylesterase 5A1 2     CES4C12
CES71 2 3     CES52
Carboxylesterase 71 2     Carboxylesterase 52
Carboxylesterase-Like Urinary Excreted Protein Homolog2 3     Cauxin3
CAUXIN2     EC 3.1.1.13

External Ids:    HGNC: 264591   Entrez Gene: 2212232   Ensembl: ENSG000001593987   UniProtKB: Q6NT323   

Export aliases for CES5A gene to outside databases


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CES5A Gene:
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the
hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates
with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and
may play a role in the blood-brain barrier system. This gene, also called CES5, is predominantly expressed in
peripheral tissues, including brain, kidney, lung and testis. It encodes a secreted enzyme. Because of high
levels in the urine of male domestic cats, this enzyme is also called cauxin (carboxylesterase-like urinary
excreted protein). The enzyme functions in regulating the production of a pheromone precursor and may contribute
to lipid and cholesterol transfer processes within male reproductive fluids. Multiple transcript variants
encoding different isoforms have been found for this gene. (provided by RefSeq, Jun 2010)

GeneCards Summary for CES5A Gene: 
CES5A (carboxylesterase 5A) is a protein-coding gene. Diseases associated with CES5A include alcoholism, and among its related super-pathways are the visual cycle I (vertebrates). GO annotations related to this gene include carboxylesterase activity and methyl indole-3-acetate esterase activity. An important paralog of this gene is NLGN1.

UniProtKB/Swiss-Prot: EST5A_HUMAN, Q6NT32
Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By
similarity)




(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NT_010498.15  NC_018927.2  
Regulatory elements:
   Search SABiosciences Regulatory transcription factor binding sites for CES5A
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCES5A promoter sequence
   Search SABiosciences Chromatin IP Primers for CES5A

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CES5A


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q12.2   Ensembl cytogenetic band:  16q12.2   HGNC cytogenetic band: 16q13

CES5A Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CES5A gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16M055881:  view genomic region     (about GC identifiers)

Start:
55,880,066 bp from pter      End:
55,989,943 bp from pter
Size:
109,878 bases      Orientation:
minus strand

1 alternative location:
Chr16-,NW_003315945 70,051-179,945     

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EST5A_HUMAN, Q6NT32 (See protein sequence)
Recommended Name: Carboxylesterase 5A precursor  
Size: 575 amino acids; 63926 Da
Subcellular location: Secreted (By similarity)
Caution: Was termed (Ref.1) CES5
Secondary accessions: B7Z252 B7ZLB6 Q8NBC8 Q96DN9
Alternative splicing: 4 isoforms:  Q6NT32-1   Q6NT32-2   Q6NT32-3   Q6NT32-4   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CES5A: NX_Q6NT32

Explore proteomics data for CES5A at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated (By similarity)
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6NT32

  • CES5A Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CES5A Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001137157.1  NP_001177087.1  NP_659461.1  

    ENSEMBL proteins: 
     ENSP00000461804   ENSP00000428864   ENSP00000324271   ENSP00000428571   ENSP00000290567  
     ENSP00000428887   ENSP00000461117   ENSP00000439810  

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    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005576extracellular region IEA--

    CES5A for ontologies           About GeneDecksing



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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CES: Carboxylesterases

    3 InterPro protein domains:
     IPR019826 Carboxylesterase_B_AS
     IPR019819 Carboxylesterase_B_CS
     IPR002018 CarbesteraseB

    Graphical View of Domain Structure for InterPro Entry Q6NT32

    ProtoNet protein and cluster: Q6NT32

    UniProtKB/Swiss-Prot: EST5A_HUMAN, Q6NT32
    Similarity: Belongs to the type-B carboxylesterase/lipase family


    CES5A for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EST5A_HUMAN, Q6NT32
    Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs (By
    similarity)
    Catalytic activity: A carboxylic ester + H(2)O = an alcohol + a carboxylate

         Enzyme Number (IUBMB): EC 3.1.1.11

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004091carboxylesterase activity IBA--
    GO:0016787hydrolase activity ----
    GO:0050253retinyl-palmitate esterase activity ----
    GO:0080030methyl indole-3-acetate esterase activity ----
    GO:0080031methyl salicylate esterase activity ----
         
    CES5A for ontologies           About GeneDecksing


    Phenotypes:
         1 GenomeRNAi human phenotype for CES5A:
     Increased gamma-H2AX phosphory 

    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CES5A 
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CES5A About                                                                                                See pathways by source

    SuperPathContained pathways About
    1the visual cycle I (vertebrates)
    retinol biosynthesis0.52
    2E2F transcription factor network
    E2F transcription factor network
    3Phase I, non P450
    Phase I, non P450


    3 BioSystems Pathways for CES5A
        Phase I, non P450
    E2F transcription factor network
    retinol biosynthesis



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CES5A

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    5/30 Interacting proteins for CES5A (ENSP000002905674) via UniProtKB, MINT, STRING, and/or I2D (see all 30)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CES1ENSP000003537204STRING: ENSP00000353720
    CES3ENSP000003047824STRING: ENSP00000304782
    CES4AENSP000003813974STRING: ENSP00000381397
    CYP3A43ENSP000002223824STRING: ENSP00000222382
    CDAENSP000003642124STRING: ENSP00000364212
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----

    CES5A for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CES5A (EST5A)

    Search CenterWatch for drugs/clinical trials and news about CES5A / EST5A

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
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    About This Section

    REFSEQ mRNAs for CES5A gene (3 alternative transcripts): 
    NM_001143685.1  NM_001190158.1  NM_145024.2  

    Unigene Cluster for CES5A:

    Carboxylesterase 5A
    Hs.350800  [show with all ESTs]
    Unigene Representative Sequence: NM_001143685
    9 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000521228(uc002eiq.2) ENST00000521992(uc021tir.1) ENST00000319165(uc002eio.2)
    ENST00000518005(uc002eir.2) ENST00000290567(uc002eip.2) ENST00000520435
    ENST00000541580 ENST00000544479 ENST00000536025
    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CES5A:
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    Inhib. RNA
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    Additional mRNA sequence: 

    AK056109.1 AK294334.1 AY907669.1 BC069501.1 BC069548.1 BC117126.1 BC143692.1 

    4 DOTS entries:

    DT.95154656  DT.102820600  DT.100726873  DT.95154657 

    10 AceView cDNA sequences:

    BC039073 BI822069 BM422399 NM_145024 AK056109 AX746724 BC069548 AK090997 
    BC069501 BI824830 

    GeneLoc Exon Structure

    4 Alternative Splicing Database (ASD) splice patterns (SP) for CES5A    About this scheme

    ExUns: 1a · 1b ^ 2a · 2b ^ 3 ^ 4a · 4b ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10 ^ 11 ^ 12 ^ 13
    SP1:                    -                 -                                                         
    SP2:                    -                 -                                         -               
    SP3:                    -                                                                           
    SP4:                                      -                                                         


    ECgene alternative splicing isoforms for CES5A

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CES5A expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CTCCACAGTC
    CES5A Expression
    About this image


    See CES5A Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CES5A

    SOURCE GeneReport for Unigene cluster: Hs.350800
        SABiosciences Expression via Pathway-Focused PCR Array including CES5A: 
              Drug Metabolism: Phase II Enzymes in human mouse rat

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    In Situ
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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CES5A gene from 4/8 species (see all 8)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ces5a1 , 5 carboxylesterase 5A1, 5 76.77(n)1
    69.86(a)1
      8 (45.67 cM)5
    679351  NM_001003951.21  NP_001003951.11 
     934993785 
    zebrafish
    (Danio rerio)
    Actinopterygii ces26
    ces36
    (see all 3)
    carboxylesterase 3
    (see all 3)
    43(a)
    42(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    18(17067638-17074777)
    18(17077342-17085474)
    fruit fly
    (Drosophila melanogaster)
    Insecta Nlg16
    Neuroligin 1
    12(a)
    1 → many
    3R(3483971-3520596)
    worm
    (Caenorhabditis elegans)
    Secernentea nlg-16
    Neuroligin-1
    17(a)
    1 → many
    X(13625410-13631117)


    ENSEMBL Gene Tree for CES5A (if available)
    TreeFam Gene Tree for CES5A (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CES5A gene
    NLGN12  CES22  ACHE2  CES4A2  NLGN4X2  NLGN4Y2  CES32  NLGN32  
    NLGN22  CES12  CEL2  BCHE2  
    13 SIMAP similar genes for CES5A using alignment to 5 protein entries:     EST5A_HUMAN (see all proteins):
    NLGN2    CES2    CES3    CES8    CES1P1    CES4A
    TG    CES hBr2    CES1    DKFZp686F02202    ACHE    BCHE
    CEL

    CES5A for paralogs           About GeneDecksing


    1 Pseudogenes.org Pseudogene for CES5A
    PGOHUM00000246278


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/2610 SNPs in CES5A are shown (see all 2610)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1465159251,2
    Cuntested155907843(+) AAGGGA/G/TACTCC 6 V syn11NA 4550
    rs772780241,2
    C--41795851(+) GAATT-/A/TTTTTT 1 -- int12NA CSA 4
    rs1899918371,2
    --55879590(+) GACGGA/GGTTTC 3 -- ds50010--------
    rs71843621,2
    C--55879620(+) TCTTGA/GACTCC 3 -- ds50012Minor allele frequency- G:0.00NA 4
    rs1812458561,2
    --55879650(+) TGCCTC/TAGCCT 3 -- ds50010--------
    rs1162971501,2
    F--55879774(+) TGATCC/TGACCC 3 -- ds50011Minor allele frequency- T:0.03WA 118
    rs178413391,2
    C,F,H--55879838(+) CCATGG/CCTGAG 3 -- ds50018Minor allele frequency- C:0.01NA NS EA 672
    rs1153519531,2
    C,F--55879846(+) GAGGAT/CACCCC 3 -- ds50011Minor allele frequency- C:0.03WA 118
    rs620387081,2
    C,F--55879851(+) TACCCC/TGTCAC 3 -- ds50012Minor allele frequency- T:0.01NA EA 240
    rs18948811,2
    C,F,H--55879900(-) TGTCAC/TGGGTT 3 -- ds500118Minor allele frequency- T:0.01NS EA NA WA CSA 796

    HapMap Linkage Disequilibrium report for CES5A (55880066 - 55989943 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 10 variations for CES5A:    About this table     
    Variant IDTypeSubtypePubMed ID
    esv3683CNV Deletion18987735
    esv2714508CNV Deletion23290073
    esv2274629CNV Deletion18987734
    nsv103512CNV Loss16902084
    esv22088CNV Gain19812545
    nsv833240CNV Gain17160897
    nsv906713CNV Gain21882294
    dgv2865n71CNV Gain21882294
    dgv892e1CNV Complex17122850
    nsv7284OTHER Inversion18451855

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    2 diseases for CES5A:    About MalaCards
    alcoholism    


    CES5A for disorders           About GeneDecksing


    Export disorders for CES5A gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CES5A gene, integrated from 9 sources (see all 13):
    (articles sorted by number of sources associating them with CES5A)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Recommended nomenclature for five mammalian carboxyle sterase gene families: human, mouse, and rat genes and proteins. (PubMed id 20931200)1, 3 Holmes R.S....Maltais L.J. (2010)
    2. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    3. Molecular cloning and characterization of a novel carboxylesterase-like protein that is physiologically present at high concentrations in the urine of domestic cats (Felis catus). (PubMed id 12401131)1, 9 Miyazaki M....Yamashita T. (2003)
    4. Mammalian carboxylesterase 5: comparative biochemistr y and genomics. (PubMed id 19727319)1, 9 Holmes R.S....Vandeberg J.L. (2008)
    5. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1 Rose J.E....Uhl G.R. (2010)
    6. Mammalian carboxylesterase 3: comparative genomics an d proteomics. (PubMed id 20422440)1 Holmes R.S....VandeBerg J.L. (2010)
    7. A new class of mammalian carboxylesterase CES6. (PubMed id 20161041)1 Holmes R.S....Vandeberg J.L. (2009)
    8. Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. (PubMed id 16344560)1 Kimura K.... Sugano S. (2006)
    9. The sequence and analysis of duplication-rich human chromosome 16. (PubMed id 15616553)2 Martin J.... Pennacchio L.A. (2004)
    10. The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). (PubMed id 15489334)2 Gerhard D.S....Malek J. (2004)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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      Query String
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 221223 HGNC: 26459 AceView: FLJ31547 Ensembl:ENSG00000159398 euGenes: HUgn221223
    ECgene: CES5A H-InvDB: CES5A

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CES5A Pharmacogenomics, SNPs, Pathways

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CES5A gene:
    Search GeneIP for patents involving CES5A

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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