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Aliases for CES4A Gene

Aliases for CES4A Gene

  • Carboxylesterase 4A 2 3
  • Carboxylesterase 8 (Putative) 2 3
  • CES8 3 4
  • Carboxylesterase 6 3
  • EC 3.1.1.- 4
  • CES6 3

External Ids for CES4A Gene

Previous HGNC Symbols for CES4A Gene

  • CES8

Previous GeneCards Identifiers for CES4A Gene

  • GC16P067023

Summaries for CES4A Gene

Entrez Gene Summary for CES4A Gene

  • This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES6, encodes a secreted enzyme, and may play a role in the detoxification of drugs and xenobiotics in neural and other tissues of the body and in the cerebrospinal fluid. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2010]

GeneCards Summary for CES4A Gene

CES4A (Carboxylesterase 4A) is a Protein Coding gene. Among its related pathways are the visual cycle I (vertebrates) and E2F transcription factor network. GO annotations related to this gene include hydrolase activity and carboxylic ester hydrolase activity. An important paralog of this gene is CES2.

UniProtKB/Swiss-Prot for CES4A Gene

  • Probable carboxylesterase.

No data available for Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CES4A Gene

Genomics for CES4A Gene

Genomic Location for CES4A Gene

66,988,589 bp from pter
67,009,758 bp from pter
21,170 bases
Plus strand

Genomic View for CES4A Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CES4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CES4A Gene

No data available for Regulatory Elements for CES4A Gene

Proteins for CES4A Gene

  • Protein details for CES4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carboxylesterase 4A
    Protein Accession:
    Secondary Accessions:
    • A8KAJ6
    • B7Z349
    • B7Z3L2
    • B7Z6R3
    • Q6UX55
    • Q8N9F4

    Protein attributes for CES4A Gene

    561 amino acids
    Molecular mass:
    63529 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ88868.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305}; Sequence=BAH12248.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CES4A Gene

neXtProt entry for CES4A Gene

Proteomics data for CES4A Gene at MOPED

Post-translational modifications for CES4A Gene

  • Glycosylation at Asn 214, Asn 276, and Asn 388
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CES4A Gene

Domains & Families for CES4A Gene

Gene Families for CES4A Gene

Protein Domains for CES4A Gene

Suggested Antigen Peptide Sequences for CES4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the type-B carboxylesterase/lipase family.
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with CES4A: view

Function for CES4A Gene

Molecular function for CES4A Gene

UniProtKB/Swiss-Prot Function:
Probable carboxylesterase.

Enzyme Numbers (IUBMB) for CES4A Gene

Gene Ontology (GO) - Molecular Function for CES4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity --
GO:0052689 carboxylic ester hydrolase activity IBA --
genes like me logo Genes that share ontologies with CES4A: view
genes like me logo Genes that share phenotypes with CES4A: view

Animal Model Products

CRISPR Products

No data available for Animal Models , Transcription Factor Targets and HOMER Transcription for CES4A Gene

Localization for CES4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CES4A Gene


Subcellular locations from

Jensen Localization Image for CES4A Gene COMPARTMENTS Subcellular localization image for CES4A gene
Compartment Confidence
extracellular 3
cytosol 2

Gene Ontology (GO) - Cellular Components for CES4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
genes like me logo Genes that share ontologies with CES4A: view

Pathways & Interactions for CES4A Gene

genes like me logo Genes that share pathways with CES4A: view

Pathways by source for CES4A Gene

2 BioSystems pathways for CES4A Gene

Interacting Proteins for CES4A Gene

Gene Ontology (GO) - Biological Process for CES4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with CES4A: view

No data available for SIGNOR curated interactions for CES4A Gene

Drugs & Compounds for CES4A Gene

No Compound Related Data Available

Transcripts for CES4A Gene

Unigene Clusters for CES4A Gene

Carboxylesterase 4A:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CES4A

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CES4A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d
SP1: - - -
SP2: - - - - - -
SP3: - - -
SP4: - -

Relevant External Links for CES4A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CES4A Gene

mRNA expression in normal human tissues for CES4A Gene

mRNA differential expression in normal tissues according to GTEx for CES4A Gene

This gene is overexpressed in Pituitary (x4.7).

Protein differential expression in normal tissues from HIPED for CES4A Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CES4A Gene

SOURCE GeneReport for Unigene cluster for CES4A Gene Hs.346947

genes like me logo Genes that share expression patterns with CES4A: view

Protein tissue co-expression partners for CES4A Gene

- Elite partner

Primer Products

In Situ Assay Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and mRNA Expression by UniProt/SwissProt for CES4A Gene

Orthologs for CES4A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CES4A Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CES4A 35
  • 83.41 (n)
  • 75 (a)
CES4A 36
  • 60 (a)
(Mus musculus)
Mammalia Ces4a 35
  • 76.46 (n)
  • 71.27 (a)
Ces4a 16
Ces4a 36
  • 56 (a)
(Pan troglodytes)
Mammalia CES4A 35
  • 99.35 (n)
  • 98.92 (a)
CES4A 36
  • 75 (a)
(Rattus norvegicus)
Mammalia Ces4a 35
  • 77.24 (n)
  • 71.12 (a)
(Monodelphis domestica)
Mammalia CES4A 36
  • 48 (a)
(Ornithorhynchus anatinus)
Mammalia CES4A 36
  • 61 (a)
(Gallus gallus)
Aves -- 36
  • 35 (a)
-- 36
  • 35 (a)
(Danio rerio)
Actinopterygii ces2 36
  • 28 (a)
ces3 36
  • 29 (a)
si:ch211-93f2.1 36
  • 10 (a)
Species with no ortholog for CES4A:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CES4A Gene

Gene Tree for CES4A (if available)
Gene Tree for CES4A (if available)

Paralogs for CES4A Gene

Paralogs for CES4A Gene

genes like me logo Genes that share paralogs with CES4A: view

Variants for CES4A Gene

Sequence variations from dbSNP and Humsavar for CES4A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs3848290 -- 67,006,432(-) ACGAG(C/T)GTGGT missense, reference, intron-variant
rs3859071 -- 67,004,116(+) GATGG(G/T)GTGGT synonymous-codon, reference
rs3859072 -- 67,004,118(+) TGGTG(G/T)GGTGA missense, reference
rs3894772 -- 66,991,738(+) ggggt(A/T)atata intron-variant, upstream-variant-2KB
rs4783748 -- 66,994,096(+) actcc(A/G)tctca intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CES4A Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv827706 CNV Loss 20364138
nsv906792 CNV Loss 21882294
nsv509626 CNV Insertion 20534489
nsv906793 CNV Loss 21882294
nsv1840 CNV Insertion 18451855

Variation tolerance for CES4A Gene

Residual Variation Intolerance Score: 74.81% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.69; 66.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CES4A Gene

HapMap Linkage Disequilibrium report
Human Gene Mutation Database (HGMD)

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CES4A Gene

Disorders for CES4A Gene

Relevant External Links for CES4A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:
genes like me logo Genes that share disorders with CES4A: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CES4A Gene

Publications for CES4A Gene

  1. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. (PMID: 20931200) Holmes R.S. … Maltais L.J. (Mamm. Genome 2010) 2 67
  2. Genomic structure and transcriptional regulation of the rat, mouse, and human carboxylesterase genes. (PMID: 17364878) Hosokawa M. … Chiba K. (Drug Metab. Rev. 2007) 2 67
  3. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 67
  4. Mammalian carboxylesterase 3: comparative genomics and proteomics. (PMID: 20422440) Holmes R.S. … VandeBerg J.L. (Genetica 2010) 67
  5. A new class of mammalian carboxylesterase CES6. (PMID: 20161041) Holmes R.S. … Vandeberg J.L. (Comp. Biochem. Physiol. Part D Genomics Proteomics 2009) 67

Products for CES4A Gene

Sources for CES4A Gene

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