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Aliases for CES4A Gene

Aliases for CES4A Gene

  • Carboxylesterase 4A 2 3 5
  • Carboxylesterase 8 (Putative) 2 3
  • CES8 3 4
  • Carboxylesterase 6 3
  • EC 3.1.1.- 4
  • CES6 3

External Ids for CES4A Gene

Previous HGNC Symbols for CES4A Gene

  • CES8

Previous GeneCards Identifiers for CES4A Gene

  • GC16P067023

Summaries for CES4A Gene

Entrez Gene Summary for CES4A Gene

  • This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They also participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene, also called CES6, encodes a secreted enzyme, and may play a role in the detoxification of drugs and xenobiotics in neural and other tissues of the body and in the cerebrospinal fluid. Multiple transcript variants encoding different isoforms have been reported, but the full-length nature and/or biological validity of some variants have not been determined. [provided by RefSeq, Jun 2010]

GeneCards Summary for CES4A Gene

CES4A (Carboxylesterase 4A) is a Protein Coding gene. Among its related pathways are the visual cycle I (vertebrates) and E2F transcription factor network. GO annotations related to this gene include hydrolase activity and carboxylic ester hydrolase activity. An important paralog of this gene is CES1.

UniProtKB/Swiss-Prot for CES4A Gene

  • Probable carboxylesterase.

No data available for CIViC summary , Tocris Summary , Gene Wiki entry , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CES4A Gene

Genomics for CES4A Gene

Regulatory Elements for CES4A Gene

Enhancers for CES4A Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G066996 1.8 FANTOM5 Ensembl ENCODE dbSUPER 5.1 +8.5 8487 1.6 HNRNPUL1 FOXA2 MLX YY1 SLC30A9 ZNF121 FOS SP5 PPARG KAT8 ATP6V0D1 CES4A DYNC1LI2 CA7 CMTM4 HSF4 PIR35653 GC16P067006 GC16P066989
GH16G066510 1.5 Ensembl ENCODE dbSUPER 4.5 -476.4 -476422 3.8 PKNOX1 FOXA2 ARID4B SIN3A TCF12 ZNF121 GATA2 ELK1 FOS SP5 BEAN1 TK2 BEAN1-AS1 CKLF-CMTM1 CKLF CMTM2 CES4A GC16M066512 ENSG00000260851
GH16G066871 1.6 FANTOM5 ENCODE 2.9 -114.7 -114749 5.1 CREB3L1 MLX FEZF1 DMAP1 SLC30A9 ZNF143 ZNF263 SP3 NFYC TBX21 E2F4 CES2 CA7 PLEKHG4 ZDHHC1 KIAA0895L CENPT ENSG00000260465 FAM96B FBXL8
GH16G067013 1.7 FANTOM5 Ensembl ENCODE dbSUPER 1.8 +25.6 25596 2.2 ATF1 ARNT CREB3L1 AGO1 SIN3A ZNF121 GLIS2 ZNF416 ZNF207 SP3 ACD CENPT THAP11 CBFB ATP6V0D1 RIPOR1 CES4A FBXL8 ENSG00000280334 GC16P067020
GH16G066984 0.5 FANTOM5 dbSUPER 2.5 -3.6 -3644 0.3 FBXL8 CES4A CMTM3 CBFB TRADD CKLF CES3
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CES4A on UCSC Golden Path with GeneCards custom track

Genomic Location for CES4A Gene

66,988,589 bp from pter
67,009,758 bp from pter
21,170 bases
Plus strand

Genomic View for CES4A Gene

Genes around CES4A on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CES4A Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CES4A Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CES4A Gene

Proteins for CES4A Gene

  • Protein details for CES4A Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carboxylesterase 4A
    Protein Accession:
    Secondary Accessions:
    • A8KAJ6
    • B7Z349
    • B7Z3L2
    • B7Z6R3
    • Q6UX55
    • Q8N9F4

    Protein attributes for CES4A Gene

    561 amino acids
    Molecular mass:
    63529 Da
    Quaternary structure:
    No Data Available
    • Sequence=AAQ88868.1; Type=Miscellaneous discrepancy; Note=Chimeric cDNA.; Evidence={ECO:0000305}; Sequence=BAH12248.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CES4A Gene

neXtProt entry for CES4A Gene

Post-translational modifications for CES4A Gene

  • Glycosylation at posLast=214214, posLast=276276, and Asn388
  • Modification sites at PhosphoSitePlus

No data available for DME Specific Peptides for CES4A Gene

Domains & Families for CES4A Gene

Gene Families for CES4A Gene

Protein Domains for CES4A Gene

Suggested Antigen Peptide Sequences for CES4A Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the type-B carboxylesterase/lipase family.
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with CES4A: view

Function for CES4A Gene

Molecular function for CES4A Gene

UniProtKB/Swiss-Prot Function:
Probable carboxylesterase.

Enzyme Numbers (IUBMB) for CES4A Gene

Gene Ontology (GO) - Molecular Function for CES4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0052689 carboxylic ester hydrolase activity IEA,IBA --
genes like me logo Genes that share ontologies with CES4A: view
genes like me logo Genes that share phenotypes with CES4A: view

Animal Model Products

CRISPR Products

Inhibitory RNA Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CES4A Gene

Localization for CES4A Gene

Subcellular locations from UniProtKB/Swiss-Prot for CES4A Gene


Subcellular locations from

Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CES4A gene
Compartment Confidence
extracellular 4
mitochondrion 2
endoplasmic reticulum 2
cytosol 2
plasma membrane 1
peroxisome 1
lysosome 1

Gene Ontology (GO) - Cellular Components for CES4A Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005576 extracellular region IEA --
genes like me logo Genes that share ontologies with CES4A: view

Pathways & Interactions for CES4A Gene

genes like me logo Genes that share pathways with CES4A: view

Pathways by source for CES4A Gene

Interacting Proteins for CES4A Gene

Gene Ontology (GO) - Biological Process for CES4A Gene


No data available for SIGNOR curated interactions for CES4A Gene

Drugs & Compounds for CES4A Gene

No Compound Related Data Available

Transcripts for CES4A Gene

Unigene Clusters for CES4A Gene

Carboxylesterase 4A:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Alternative Splicing Database (ASD) splice patterns (SP) for CES4A Gene

ExUns: 1 ^ 2a · 2b · 2c ^ 3a · 3b ^ 4 ^ 5 ^ 6 ^ 7 ^ 8 ^ 9 ^ 10a · 10b ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c · 13d
SP1: - - -
SP2: - - - - - -
SP3: - - -
SP4: - -

Relevant External Links for CES4A Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CES4A Gene

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CES4A Gene

mRNA differential expression in normal tissues according to GTEx for CES4A Gene

This gene is overexpressed in Pituitary (x4.7).

Protein differential expression in normal tissues from HIPED for CES4A Gene

This gene is overexpressed in Heart (69.0).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, and MOPED for CES4A Gene

Protein tissue co-expression partners for CES4A Gene

- Elite partner

NURSA nuclear receptor signaling pathways regulating expression of CES4A Gene:


SOURCE GeneReport for Unigene cluster for CES4A Gene:


Evidence on tissue expression from TISSUES for CES4A Gene

  • Nervous system(4.2)
  • Blood(4.1)
genes like me logo Genes that share expression patterns with CES4A: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , mRNA Expression by UniProt/SwissProt and Phenotype-based relationships between genes and organs from Gene ORGANizer for CES4A Gene

Orthologs for CES4A Gene

This gene was present in the common ancestor of chordates.

Orthologs for CES4A Gene

Organism Taxonomy Gene Similarity Type Details
(Pan troglodytes)
Mammalia CES4A 34 35
  • 99.35 (n)
(Bos Taurus)
Mammalia CES4A 34 35
  • 83.41 (n)
(Rattus norvegicus)
Mammalia Ces4a 34
  • 77.24 (n)
(Mus musculus)
Mammalia Ces4a 34 16 35
  • 76.46 (n)
(Ornithorhynchus anatinus)
Mammalia CES4A 35
  • 61 (a)
(Monodelphis domestica)
Mammalia CES4A 35
  • 48 (a)
(Gallus gallus)
Aves -- 35
  • 35 (a)
-- 35
  • 35 (a)
(Danio rerio)
Actinopterygii ces3 35
  • 29 (a)
ces2 35
  • 28 (a)
si:ch211-93f2.1 35
  • 10 (a)
Species where no ortholog for CES4A was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • fruit fly (Drosophila melanogaster)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)
  • worm (Caenorhabditis elegans)

Evolution for CES4A Gene

Gene Tree for CES4A (if available)
Gene Tree for CES4A (if available)

Paralogs for CES4A Gene

Variants for CES4A Gene

Sequence variations from dbSNP and Humsavar for CES4A Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000845454 -- 66,990,061(+) TTTTT(C/T)TTTTT intron-variant
rs1000947993 -- 66,994,093(+) AAGAC(A/T)CCATC intron-variant
rs1001019954 -- 66,993,970(+) GTGGC(A/G)GGTGC intron-variant
rs1001111840 -- 67,000,214(+) GGGTA(C/T)TGTCC intron-variant, upstream-variant-2KB, utr-variant-5-prime
rs1001120067 -- 67,003,513(+) CCCAT(A/G)GAGAT splice-acceptor-variant

Structural Variations from Database of Genomic Variants (DGV) for CES4A Gene

Variant ID Type Subtype PubMed ID
dgv526e214 CNV gain 21293372
nsv1840 CNV insertion 18451855
nsv509626 CNV insertion 20534489
nsv827706 CNV loss 20364138

Variation tolerance for CES4A Gene

Residual Variation Intolerance Score: 74.8% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.69; 66.02% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CES4A Gene

Human Gene Mutation Database (HGMD)
SNPedia medical, phenotypic, and genealogical associations of SNPs for

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CES4A Gene

Disorders for CES4A Gene

Relevant External Links for CES4A

Atlas of Genetics and Cytogenetics in Oncology and Haematology:

No disorders were found for CES4A Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CES4A Gene

Publications for CES4A Gene

  1. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PMID: 12975309) Clark H.F. … Gray A.M. (Genome Res. 2003) 2 3 4 64
  2. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. (PMID: 20931200) Holmes R.S. … Maltais L.J. (Mamm. Genome 2010) 2 3 64
  3. Genomic structure and transcriptional regulation of the rat, mouse, and human carboxylesterase genes. (PMID: 17364878) Hosokawa M. … Chiba K. (Drug Metab. Rev. 2007) 2 3 64
  4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PMID: 14702039) Ota T. … Sugano S. (Nat. Genet. 2004) 3 4 64
  5. Mammalian carboxylesterase 3: comparative genomics and proteomics. (PMID: 20422440) Holmes R.S. … VandeBerg J.L. (Genetica 2010) 3 64

Products for CES4A Gene

Sources for CES4A Gene

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