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Aliases for CES3 Gene

Aliases for CES3 Gene

  • Carboxylesterase 3 2 3
  • Liver Carboxylesterase 31 Homolog 3 4
  • Carboxylesterase 3 (Brain) 2 3
  • Esterase 31 2 3
  • EC 3.1.1.1 4 63
  • Brain Carboxylesterase BR3 2
  • EC 3.1.1 63
  • ES31 3

External Ids for CES3 Gene

Previous GeneCards Identifiers for CES3 Gene

  • GC16U990091
  • GC16P055532
  • GC16M055612
  • GC16M054394
  • GC16P065553
  • GC16P066995
  • GC16P052869

Summaries for CES3 Gene

Entrez Gene Summary for CES3 Gene

  • This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]

GeneCards Summary for CES3 Gene

CES3 (Carboxylesterase 3) is a Protein Coding gene. Among its related pathways are E2F transcription factor network. GO annotations related to this gene include hydrolase activity and carboxylic ester hydrolase activity. An important paralog of this gene is CES2.

UniProtKB/Swiss-Prot for CES3 Gene

  • Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics

Gene Wiki entry for CES3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CES3 Gene

Genomics for CES3 Gene

Regulatory Elements for CES3 Gene

Genomic Location for CES3 Gene

Chromosome:
16
Start:
66,961,229 bp from pter
End:
66,975,149 bp from pter
Size:
13,921 bases
Orientation:
Plus strand

Genomic View for CES3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CES3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CES3 Gene

Proteins for CES3 Gene

  • Protein details for CES3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWW8-EST3_HUMAN
    Recommended name:
    Carboxylesterase 3
    Protein Accession:
    Q6UWW8
    Secondary Accessions:
    • B2Z3W9
    • F5H242
    • Q7Z6J1
    • Q9H6X7

    Protein attributes for CES3 Gene

    Size:
    571 amino acids
    Molecular mass:
    62282 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CES3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CES3 Gene

Proteomics data for CES3 Gene at MOPED

Selected DME Specific Peptides for CES3 Gene

Post-translational modifications for CES3 Gene

Other Protein References for CES3 Gene

Antibody Products

  • R&D Systems Antibodies for CES3 (Carboxylesterase 3/CES3)

Domains & Families for CES3 Gene

Gene Families for CES3 Gene

Protein Domains for CES3 Gene

Suggested Antigen Peptide Sequences for CES3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWW8

UniProtKB/Swiss-Prot:

EST3_HUMAN :
  • Belongs to the type-B carboxylesterase/lipase family.
Family:
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with CES3: view

Function for CES3 Gene

Molecular function for CES3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=137 uM for 7-ethyl-10-[4-(1-piperidino)-1-piperidino]- carbonyloxycamptothecin {ECO:0000269 PubMed:15100172}; KM=460 uM for 7-ethyl-10-[4-(1-piperidino)-1-amino]- carbonyloxycamptothecin {ECO:0000269 PubMed:15100172};
UniProtKB/Swiss-Prot CatalyticActivity:
A carboxylic ester + H(2)O = an alcohol + a carboxylate.
UniProtKB/Swiss-Prot Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics

Enzyme Numbers (IUBMB) for CES3 Gene

Gene Ontology (GO) - Molecular Function for CES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0004771 sterol esterase activity IBA --
GO:0004806 triglyceride lipase activity IBA --
GO:0016787 hydrolase activity --
genes like me logo Genes that share ontologies with CES3: view
genes like me logo Genes that share phenotypes with CES3: view

Animal Models for CES3 Gene

MGI Knock Outs for CES3:

Animal Model Products

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CES3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targets and HOMER Transcription for CES3 Gene

Localization for CES3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CES3 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CES3 Gene COMPARTMENTS Subcellular localization image for CES3 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 3

Gene Ontology (GO) - Cellular Components for CES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with CES3: view

Pathways & Interactions for CES3 Gene

genes like me logo Genes that share pathways with CES3: view

Pathways by source for CES3 Gene

1 BioSystems pathway for CES3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism in human,mouse,rat
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat

Interacting Proteins for CES3 Gene

Gene Ontology (GO) - Biological Process for CES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0016042 lipid catabolic process IBA --
genes like me logo Genes that share ontologies with CES3: view

No data available for SIGNOR curated interactions for CES3 Gene

Drugs & Compounds for CES3 Gene

(5) Drugs for CES3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 20
Stearic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0
arachidonic acid Experimental Nutra Potentiation, Activator 27

(5) Additional Compounds for CES3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
3546-17-6
Pentadecanoic acid
  • N-Pentadecanoate
  • N-Pentadecanoic acid
  • N-Pentadecylate
  • N-Pentadecylic acid
  • Pentadecanoate
1002-84-2
Water
  • Dihydrogen oxide
  • Steam
7732-18-5
genes like me logo Genes that share compounds with CES3: view

Transcripts for CES3 Gene

mRNA/cDNA for CES3 Gene

(6) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CES3 Gene

Carboxylesterase 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CES3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CES3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5:
SP6:

Relevant External Links for CES3 Gene

GeneLoc Exon Structure for
CES3
ECgene alternative splicing isoforms for
CES3

Expression for CES3 Gene

mRNA expression in normal human tissues for CES3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CES3 Gene

This gene is overexpressed in Colon - Transverse (x15.5), Liver (x9.4), and Muscle - Skeletal (x6.0).

Protein differential expression in normal tissues from HIPED for CES3 Gene

This gene is overexpressed in Milk (24.2), Colon (14.8), Stomach (12.2), and Gallbladder (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MOPED, and MaxQB for CES3 Gene



SOURCE GeneReport for Unigene cluster for CES3 Gene Hs.268700

mRNA Expression by UniProt/SwissProt for CES3 Gene

Q6UWW8-EST3_HUMAN
Tissue specificity: Expressed in liver, colon and small intestine.
genes like me logo Genes that share expression patterns with CES3: view

Protein tissue co-expression partners for CES3 Gene

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for CES3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CES3 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CES3 35
  • 79.82 (n)
  • 71.05 (a)
CES3 36
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ces3b 35
  • 75.23 (n)
  • 67.52 (a)
Ces1d 16
Ces3a 36
  • 65 (a)
OneToMany
Ces3b 36
  • 66 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CES3 35
  • 98.89 (n)
  • 97.9 (a)
CES3 36
  • 98 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ces3a 35
  • 74.05 (n)
  • 61.15 (a)
oppossum
(Monodelphis domestica)
Mammalia CES3 36
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CES3 36
  • 52 (a)
OneToOne
zebrafish
(Danio rerio)
Actinopterygii ces2 36
  • 41 (a)
ManyToMany
ces3 36
  • 41 (a)
ManyToMany
si:ch211-93f2.1 36
  • 14 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta alpha-Est10 37
  • 29 (a)
alpha-Est2 37
  • 30 (a)
alpha-Est3 37
  • 28 (a)
alpha-Est4 37
  • 38 (a)
alpha-Est6 37
  • 30 (a)
alpha-Est7 37
  • 30 (a)
alpha-Est8 37
  • 31 (a)
alpha-Est9 37
  • 28 (a)
BcDNA:GH05741 37
  • 30 (a)
CG10175 37
  • 29 (a)
CG10339 37
  • 26 (a)
CG3841 37
  • 34 (a)
CG4382 37
  • 28 (a)
CG5397 37
  • 28 (a)
CG6018 37
  • 30 (a)
CG6414 37
  • 29 (a)
CG7529 37
  • 26 (a)
CG8424 37
  • 42 (a)
CG9289 37
  • 27 (a)
clt 37
  • 31 (a)
Est-6 37
  • 27 (a)
Est-P 37
  • 29 (a)
Jhe 37
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea B0238.1 37
  • 31 (a)
B0238.13 37
  • 33 (a)
B0238.7 37
  • 29 (a)
C52A10.1 37
  • 31 (a)
C52A10.2 37
  • 31 (a)
F07C4.12 37
  • 30 (a)
F13H6.3 37
  • 30 (a)
F13H6.4 37
  • 29 (a)
F15A8.6 37
  • 45 (a)
F55D10.3 37
  • 27 (a)
ges-1 37
  • 28 (a)
K07C11.4 37
  • 28 (a)
K11G9.1 37
  • 41 (a)
K11G9.2 37
  • 27 (a)
R173.3 37
  • 37 (a)
T02B5.1 37
  • 26 (a)
T02B5.3 37
  • 27 (a)
T07H6.1a 37
  • 26 (a)
T28C12.4a 37
  • 29 (a)
T28C12.4b 37
  • 29 (a)
Y71H2AM.13 37
  • 30 (a)
Y75B8A.3 37
  • 36 (a)
ZC376.2 37
  • 24 (a)
Species with no ortholog for CES3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CES3 Gene

ENSEMBL:
Gene Tree for CES3 (if available)
TreeFam:
Gene Tree for CES3 (if available)

Paralogs for CES3 Gene

Paralogs for CES3 Gene

(16) SIMAP similar genes for CES3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CES3: view

Variants for CES3 Gene

Sequence variations from dbSNP and Humsavar for CES3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1211027 -- 66,968,302(-) ctgta(A/G)tccca intron-variant
rs1211028 -- 66,968,289(-) tactc(A/G)ggagg intron-variant
rs1308554 -- 66,968,464(-) CCAGg(A/G)ccggg intron-variant
rs1308555 -- 66,968,428(-) cattt(C/T)gggag intron-variant
rs3848289 -- 66,972,935(-) CCGGC(C/T)CGTGG synonymous-codon, reference

Structural Variations from Database of Genomic Variants (DGV) for CES3 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv827706 CNV Loss 20364138
nsv906791 CNV Loss 21882294
nsv906792 CNV Loss 21882294

Variation tolerance for CES3 Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.28; 62.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CES3 Gene

HapMap Linkage Disequilibrium report
CES3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CES3 Gene

Disorders for CES3 Gene

Relevant External Links for CES3

Human Genome Epidemiology (HuGE) Navigator
CES3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CES3
genes like me logo Genes that share disorders with CES3: view

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CES3 Gene

Publications for CES3 Gene

  1. Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10- [4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. (PMID: 15100172) Sanghani S.P. … Bosron W.F. (Drug Metab. Dispos. 2004) 2 23 67
  2. Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis. (PMID: 14581373) Sanghani S.P. … Bosron W.F. (Clin. Cancer Res. 2003) 2 23 67
  3. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. (PMID: 20931200) Holmes R.S. … Maltais L.J. (Mamm. Genome 2010) 2 67
  4. Mammalian carboxylesterase 3: comparative genomics and proteomics. (PMID: 20422440) Holmes R.S. … VandeBerg J.L. (Genetica 2010) 23 67
  5. Human carboxylesterases: an update on CES1, CES2 and CES3. (PMID: 19508181) Sanghani S.P. … Bosron W.F. (Protein Pept. Lett. 2009) 23 67

Products for CES3 Gene

Sources for CES3 Gene

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