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CES3 Gene(Protein Coding)

Carboxylesterase 3

GCID:
GC16P066963
GIFtS:
55
Genes Participants
UDN Logo

Aliases for CES3 Gene

Aliases for CES3 Gene

  • Carboxylesterase 3 2 3 5
  • Liver Carboxylesterase 31 Homolog 3 4
  • Carboxylesterase 3 (Brain) 2 3
  • Esterase 31 2 3
  • EC 3.1.1.1 4 61
  • Brain Carboxylesterase BR3 2
  • EC 3.1.1 61
  • ES31 3

External Ids for CES3 Gene

Previous GeneCards Identifiers for CES3 Gene

  • GC16U990091
  • GC16P055532
  • GC16M055612
  • GC16M054394
  • GC16P065553
  • GC16P066995
  • GC16P052869

Summaries for CES3 Gene

Entrez Gene Summary for CES3 Gene

  • This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]

GeneCards Summary for CES3 Gene

CES3 (Carboxylesterase 3) is a Protein Coding gene. Among its related pathways are Lipoprotein metabolism and E2F transcription factor network. GO annotations related to this gene include hydrolase activity and carboxylic ester hydrolase activity. An important paralog of this gene is CES2.

UniProtKB/Swiss-Prot for CES3 Gene

  • Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.

Gene Wiki entry for CES3 Gene

No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CES3 Gene

Genomics for CES3 Gene

Products:

  1. Regulatory Element

Regulatory Elements for CES3 Gene

Enhancers for CES3 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
GH16G066902 2.3 VISTA FANTOM5 Ensembl ENCODE dbSUPER 9.5 -56.7 -56689 4.1 PKNOX1 FOXA2 MLX ARNT ARID4B DMAP1 ZNF2 ZNF48 YY1 FOS CES2 KIAA0895L E2F4 RRAD FAM96B CENPT EXOC3L1 C16orf70 CES3 LINC00920
GH16G066952 1.7 FANTOM5 Ensembl ENCODE dbSUPER 12 -7.6 -7570 2.4 ARID4B ZNF48 YY1 SLC30A9 ZNF121 ZNF143 SP5 REST MIER2 PPARG CES3 LRRC29 LRRC36 GC16M066947 ENSG00000280416
GH16G066947 1.4 Ensembl ENCODE dbSUPER 11.9 -13.2 -13171 1.9 ATF1 AGO1 WRNIP1 ARID4B SIN3A YY1 ZNF143 PAF1 SP5 NFYC CES3 ENSG00000280416 GC16M066947
GH16G066932 1.4 ENCODE dbSUPER 11.8 -25.9 -25928 5.0 FOXA2 MLX CREB3L1 ARID4B SIN3A DMAP1 ZNF2 YY1 SLC30A9 ZNF302 CES3 CES2 NAE1 ENSG00000265408
GH16G066899 1.7 Ensembl ENCODE dbSUPER 9.3 -60.5 -60502 3.4 CREB3L1 DMAP1 YY1 SLC30A9 ZNF143 SP3 NFYC MEF2D SSRP1 ZNF610 CES2 E2F4 RRAD FAM96B LINC00920 FBXL8 TRADD HSF4 PLEKHG4 EXOC3L1
- Elite enhancer and/or Elite enhancer-gene association Download GeneHancer data dump

Enhancers around CES3 on UCSC Golden Path with GeneCards custom track

Transcription factor binding sites by QIAGEN in the CES3 gene promoter:

Genomic Location for CES3 Gene

Chromosome:
16
Start:
66,961,229 bp from pter
End:
66,975,149 bp from pter
Size:
13,921 bases
Orientation:
Plus strand

Genomic View for CES3 Gene

Genes around CES3 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CES3 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CES3 Gene
GeneLoc Logo Genomic Neighborhood • Exon Structure • Gene Density

RefSeq DNA sequence for CES3 Gene

Proteins for CES3 Gene

Products:

  1. Antibody
  2. Protein
  3. Assay

  • Protein details for CES3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWW8-EST3_HUMAN
    Recommended name:
    Carboxylesterase 3
    Protein Accession:
    Q6UWW8
    Secondary Accessions:
    • B2Z3W9
    • F5H242
    • Q7Z6J1
    • Q9H6X7

    Protein attributes for CES3 Gene

    Size:
    571 amino acids
    Molecular mass:
    62282 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CES3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CES3 Gene

Protein Expression for CES3 Gene

See protein expression from ProteomicsDB, MOPED, PaxDb, and MaxQB

Selected DME Specific Peptides for CES3 Gene

Q6UWW8:
  • GFFSTGD
  • FLGIPFA
  • FARTGDPN
  • AALRWVQ
  • YRLGVLGF

Post-translational modifications for CES3 Gene

Other Protein References for CES3 Gene

ENSEMBL proteins:
REFSEQ proteins:

Domains & Families for CES3 Gene

Gene Families for CES3 Gene

HGNC:

Protein Domains for CES3 Gene

InterPro:
ProtoNet:

Suggested Antigen Peptide Sequences for CES3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry

Q6UWW8

UniProtKB/Swiss-Prot:

EST3_HUMAN :
  • Belongs to the type-B carboxylesterase/lipase family.
Family:
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with CES3: view

Function for CES3 Gene

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  1. Animal Model
  2. CRISPR
  3. miRNA
  4. Inhibitory RNA
  5. Clone
  6. Cell Line
  7. Flow Cytometry

Molecular function for CES3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=137 uM for 7-ethyl-10-[4-(1-piperidino)-1-piperidino]- carbonyloxycamptothecin {ECO:0000269 PubMed:15100172}; KM=460 uM for 7-ethyl-10-[4-(1-piperidino)-1-amino]- carbonyloxycamptothecin {ECO:0000269 PubMed:15100172};
UniProtKB/Swiss-Prot CatalyticActivity:
A carboxylic ester + H(2)O = an alcohol + a carboxylate.
UniProtKB/Swiss-Prot Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics.

Enzyme Numbers (IUBMB) for CES3 Gene

Gene Ontology (GO) - Molecular Function for CES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity IEA --
GO:0052689 carboxylic ester hydrolase activity TAS --
genes like me logo Genes that share ontologies with CES3: view
genes like me logo Genes that share phenotypes with CES3: view

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Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CES3 Gene

Localization for CES3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CES3 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Extracellular space Cytosol Plasma membrane Cytoskeleton Lysosome Endosome Peroxisome ER Golgi Apparatus Nucleus Mitochondrion 0 1 2 3 4 5 Confidence
COMPARTMENTS Subcellular localization image for CES3 gene
Compartment Confidence
extracellular 5
endoplasmic reticulum 4
cytosol 4
lysosome 1

Gene Ontology (GO) - Cellular Components for CES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0005829 cytosol TAS --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with CES3: view

Pathways & Interactions for CES3 Gene

genes like me logo Genes that share pathways with CES3: view

Interacting Proteins for CES3 Gene

STRING Interaction Network Preview (showing 5 interactants - click image to see 25)
http://string-db.org/version_10/api/image/networkList?limit=0&targetmode=proteins&caller_identity=gene_cards&network_flavor=evidence&identifiers=9606.ENSP00000304782%0d%0a9606.ENSP00000420616%0d%0a9606.ENSP00000364519%0d%0a9606.ENSP00000317842%0d%0a9606.ENSP00000353720%0d%0a9606.ENSP00000444052%0d%0a
Selected Interacting proteins: ENSP00000304782 Q6UWW8-EST3_HUMAN for CES3 Gene via STRING IID

Gene Ontology (GO) - Biological Process for CES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0006898 receptor-mediated endocytosis TAS --
GO:0034383 low-density lipoprotein particle clearance TAS --
genes like me logo Genes that share ontologies with CES3: view

No data available for SIGNOR curated interactions for CES3 Gene

Drugs & Compounds for CES3 Gene

Products:

  1. Drug

(6) Drugs for CES3 Gene - From: HMDB

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Water Approved Pharma 0
MYRISTIC ACID Experimental Pharma 0
Palmitic Acid Experimental Pharma Full agonist, Agonist 22
Stearic acid Experimental Pharma 0
Tridecanoic acid Experimental Pharma 0

(4) Additional Compounds for CES3 Gene - From: HMDB

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
Arachidic acid
  • Arachate
  • Arachic acid
  • Arachidate
  • Arachidic acid
  • Eicosanoate
 506-30-9
Heptadecanoic acid
  • Heptadecanoate
  • Heptadecanoic acid
  • Margarate
  • Margaric acid
  • Margarinate
 506-12-7
Heptadecanoyl CoA
  • Heptadecanoate
  • Heptadecanoic acid
  • Heptadecanoic acid coa
  • Heptadecanoyl coenzyme A
  • Heptadecanoyl-coA
 3546-17-6
Pentadecanoic acid
  • N-Pentadecanoate
  • N-Pentadecanoic acid
  • N-Pentadecylate
  • N-Pentadecylic acid
  • Pentadecanoate
 1002-84-2
genes like me logo Genes that share compounds with CES3: view

Transcripts for CES3 Gene

Products:

  1. CRISPR
  2. miRNA
  3. Inhibitory RNA
  4. Clone
  5. Flow Cytometry

mRNA/cDNA for CES3 Gene

(6) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CES3 Gene

Carboxylesterase 3:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

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Alternative Splicing Database (ASD) splice patterns (SP) for CES3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5:
SP6:

Relevant External Links for CES3 Gene

GeneLoc Exon Structure for
CES3
ECgene alternative splicing isoforms for
CES3

Expression for CES3 Gene

Products:

  1. Primer

mRNA expression in normal human tissues from GTEx, Illumina, BioGPS, and CGAP SAGE for CES3 Gene

mRNA expression in normal human tissues for CES3 Gene
mRNA expression by BioGPS for CES3 GenemRNA expression by GTEx for CES3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CES3 Gene

This gene is overexpressed in Colon - Transverse (x15.5), Liver (x9.4), and Muscle - Skeletal (x6.0).

Protein differential expression in normal tissues from HIPED for CES3 Gene

This gene is overexpressed in Milk (24.2), Colon (14.8), Stomach (12.2), and Gallbladder (10.1).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CES3 Gene



Protein tissue co-expression partners for CES3 Gene

NURSA nuclear receptor signaling pathways regulating expression of CES3 Gene:

CES3

SOURCE GeneReport for Unigene cluster for CES3 Gene:

Hs.268700

mRNA Expression by UniProt/SwissProt for CES3 Gene:

Q6UWW8-EST3_HUMAN
Tissue specificity: Expressed in liver, colon and small intestine.

Evidence on tissue expression from TISSUES for CES3 Gene

  • Liver(4.4)
  • Intestine(4.3)
  • Eye(4)
genes like me logo Genes that share expression patterns with CES3: view

Primer Products

No data available for Phenotype-based relationships between genes and organs from Gene ORGANizer for CES3 Gene

Orthologs for CES3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CES3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
 Mammalia CES3 34 35
  • 98.89 (n)
cow
(Bos Taurus)
 Mammalia CES3 34 35
  • 79.82 (n)
mouse
(Mus musculus)
 Mammalia Ces3b 34 16 35
  • 75.23 (n)
Ces3a 35
  • 65 (a)
 OneToMany
rat
(Rattus norvegicus)
 Mammalia Ces3a 34
  • 74.05 (n)
platypus
(Ornithorhynchus anatinus)
 Mammalia CES3 35
  • 52 (a)
 OneToOne
oppossum
(Monodelphis domestica)
 Mammalia CES3 35
  • 51 (a)
 OneToOne
zebrafish
(Danio rerio)
 Actinopterygii ces2 35
  • 41 (a)
 ManyToMany
ces3 35
  • 41 (a)
 ManyToMany
si:ch211-93f2.1 35
  • 14 (a)
 ManyToMany
fruit fly
(Drosophila melanogaster)
 Insecta CG8424 36
  • 42 (a)
alpha-Est4 36
  • 38 (a)
CG3841 36
  • 34 (a)
alpha-Est8 36
  • 31 (a)
clt 36
  • 31 (a)
alpha-Est2 36
  • 30 (a)
alpha-Est6 36
  • 30 (a)
alpha-Est7 36
  • 30 (a)
BcDNA:GH05741 36
  • 30 (a)
CG6018 36
  • 30 (a)
Jhe 36
  • 30 (a)
alpha-Est10 36
  • 29 (a)
CG10175 36
  • 29 (a)
CG6414 36
  • 29 (a)
Est-P 36
  • 29 (a)
alpha-Est3 36
  • 28 (a)
alpha-Est9 36
  • 28 (a)
CG4382 36
  • 28 (a)
CG5397 36
  • 28 (a)
CG9289 36
  • 27 (a)
Est-6 36
  • 27 (a)
CG10339 36
  • 26 (a)
CG7529 36
  • 26 (a)
worm
(Caenorhabditis elegans)
 Secernentea F15A8.6 36
  • 45 (a)
K11G9.1 36
  • 41 (a)
R173.3 36
  • 37 (a)
Y75B8A.3 36
  • 36 (a)
B0238.13 36
  • 33 (a)
B0238.1 36
  • 31 (a)
C52A10.1 36
  • 31 (a)
C52A10.2 36
  • 31 (a)
F07C4.12 36
  • 30 (a)
F13H6.3 36
  • 30 (a)
Y71H2AM.13 36
  • 30 (a)
B0238.7 36
  • 29 (a)
F13H6.4 36
  • 29 (a)
T28C12.4a 36
  • 29 (a)
T28C12.4b 36
  • 29 (a)
ges-1 36
  • 28 (a)
K07C11.4 36
  • 28 (a)
F55D10.3 36
  • 27 (a)
K11G9.2 36
  • 27 (a)
T02B5.3 36
  • 27 (a)
T02B5.1 36
  • 26 (a)
T07H6.1a 36
  • 26 (a)
ZC376.2 36
  • 24 (a)
Species where no ortholog for CES3 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CES3 Gene

ENSEMBL:
Gene Tree for CES3 (if available)
TreeFam:
Gene Tree for CES3 (if available)

Paralogs for CES3 Gene

Paralogs for CES3 Gene

(16) SIMAP similar genes for CES3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CES3: view

Variants for CES3 Gene

Sequence variations from dbSNP and Humsavar for CES3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
rs1000038179 -- 66,971,375(+) GCTGG(A/G)TCATC intron-variant, downstream-variant-500B
rs1000091655 -- 66,971,143(+) CCTGA(A/G)CAGGG intron-variant
rs1000285868 -- 66,967,163(+) CTTCA(A/G)CCTCC intron-variant, upstream-variant-2KB
rs1000580779 -- 66,975,132(+) GCAAT(A/G)AATCT utr-variant-3-prime
rs1001013068 -- 66,960,406(+) TTCTC(-/TT)TTTGT upstream-variant-2KB

Structural Variations from Database of Genomic Variants (DGV) for CES3 Gene

Variant ID Type Subtype PubMed ID
dgv526e214 CNV gain 21293372
nsv827706 CNV loss 20364138

Variation tolerance for CES3 Gene

Residual Variation Intolerance Score: 93.6% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 4.28; 62.65% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CES3 Gene

SNPedia medical, phenotypic, and genealogical associations of SNPs for
CES3

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CES3 Gene

Disorders for CES3 Gene

Relevant External Links for CES3

Human Genome Epidemiology (HuGE) Navigator
CES3
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CES3

No disorders were found for CES3 Gene.

No data available for MalaCards , UniProtKB/Swiss-Prot and Genatlas for CES3 Gene

Publications for CES3 Gene

  1. Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10- [4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. (PMID: 15100172) Sanghani S.P. … Bosron W.F. (Drug Metab. Dispos. 2004) 2 3 4 22 64
  2. Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis. (PMID: 14581373) Sanghani S.P. … Bosron W.F. (Clin. Cancer Res. 2003) 2 3 4 22 64
  3. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. (PMID: 20931200) Holmes R.S. … Maltais L.J. (Mamm. Genome 2010) 2 3 64
  4. Mammalian carboxylesterase 3: comparative genomics and proteomics. (PMID: 20422440) Holmes R.S. … VandeBerg J.L. (Genetica 2010) 3 22 64
  5. Human carboxylesterases: an update on CES1, CES2 and CES3. (PMID: 19508181) Sanghani S.P. … Bosron W.F. (Protein Pept. Lett. 2009) 3 22 64

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