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Category Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21

GIFtS
-

CES3 Gene

protein-coding GIFtS: 57
GCID: GC16P066995

carboxylesterase 3

(Previous name: carboxylesterase 3 (brain) )

Explore 5 diseases affiliated with
CES3 via

MalaCards

our new
Human Malady Compendium

(According to ¹HGNC, ²Entrez Gene,
³UniProtKB/Swiss-Prot, ⁴UniProtKB/TrEMBL, ⁵OMIM, ⁶GeneLoc, ⁷Ensembl, ⁸DME, ⁹miRBase, and/or ¹⁰fRNAdb)
About This Section

Aliases
Carboxylesterase 3¹ ²		EC 3.1.1.1³ ⁸
ES31¹ ² ⁵		FLJ21736¹
Carboxylesterase 3 (Brain)¹ ²		Esterase 31²
Liver Carboxylesterase 31 Homolog² ³		EC 3.1.1⁸

External Ids:	HGNC: 1865¹	Entrez Gene: 23491²	Ensembl: ENSG00000172828⁷	OMIM: 605279⁵	UniProtKB: Q6UWW8³

Export aliases for CES3 gene to outside databases

Previous GC identifers: GC16U990091 GC16P055532 GC16M055612 GC16M054394 GC16P065553 GC16P052869

(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CES3:

This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis

or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester,

thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in

the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in

brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript

variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some

variants have not been determined.(provided by RefSeq, Jun 2010)

UniProtKB/Swiss-Prot: EST3_HUMAN, Q6UWW8

Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low

catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a

prodrug for camptothecin used in cancer therapeutics

Gene Wiki entry for CES3 (Carboxylesterase 3)

(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 69), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section

RefSeq DNA sequence:

NC_000016.9 NC_018927.1 NT_010498.15

Regulatory elements:

SABiosciences Regulatory transcription factor binding sites in the CES3 gene promoter:
GR HEN1 Pax-3 AML1a GR-alpha NF-kappaB1 C/EBPalpha
Other transcription factors

SwitchGear Promoter luciferase reporter plasmid: CES3 promoter sequence

Search SABiosciences Chromatin IP Primers for CES3

Epigenetics:

QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CES3

Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1 Ensembl cytogenetic band: 16q22.1 HGNC cytogenetic band: 16q22.1

CES3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CES3 gene location

GeneLoc information about chromosome 16 GeneLoc Exon Structure

GeneLoc location for GC16P066995: view genomic region (about GC identifiers)

Start:	66,995,132 bp from pter	End:	67,009,052 bp from pter
Size:	13,921 bases	Orientation:	plus strand

(According to ¹UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to ²PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE MOPED and PaxDb, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Uscn,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Uscn, Ontologies according to Gene Ontology Consortium 01 Mar 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, Abcam, and/or Uscn)
About This Section

UniProtKB/Swiss-Prot: EST3_HUMAN, Q6UWW8 (See protein sequence)

Recommended Name: Carboxylesterase 3 precursor

Size: 571 amino acids; 62282 Da

Subcellular location: Endoplasmic reticulum lumen (By similarity)

Secondary accessions: B2Z3W9 F5H242 Q7Z6J1 Q9H6X7

Alternative splicing: 2 isoforms: Q6UWW8-1 Q6UWW8-2 (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CES3: NX_Q6UWW8

Post-translational modifications:

N-glycosylated¹

View modification sites using PhosphoSitePlus²

View neXtProt modification sites for NX_Q6UWW8

4/5 DME Specific Peptides for CES3 (Q6UWW8) (see all 5)

GFFSTGD

AALRWVQ

FLGIPFA

FARTGDPN

CES3 Protein expression data from MOPED and PaxDb: About this image

REFSEQ proteins (3 alternative transcripts):

NP_001172105.1 NP_001172106.1 NP_079198.2

ENSEMBL proteins:

ENSP00000304782 ENSP00000377602 ENSP00000456203 ENSP00000457547 ENSP00000445559

Human Recombinant Protein Products:

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	Novus Biologicals CES3 Protein Novus Biologicals CES3 Lysates
	Browse Sino Biological Recombinant Proteins
	Browse ProSpec Recombinant Proteins
	Uscn Proteins for CES3

Gene Ontology (GO): 1 cellular component term (GO ID links to tree view): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0005788	endoplasmic reticulum lumen	IEA	--

CES3 for ontologies About GeneDecksing

CES3 Antibody Products:

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	Uscn ELISAs and CLIAs for CES3

(According to InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
About This Section

CES3 for domains About GeneDecksing

2 InterPro domains/families:

IPR019826 Carboxylesterase_B_AS

IPR002018 CarbesteraseB

Graphical View of Domain Structure for InterPro Entry Q6UWW8

ProtoNet protein and cluster: Q6UWW8

UniProtKB/Swiss-Prot: EST3_HUMAN, Q6UWW8

Similarity: Belongs to the type-B carboxylesterase/lipase family

(According to ¹UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or ²DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013,
bound targets from SABiosciences, miRNA Gene Targets from miRTarBase shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene.)
About This Section

Function Summary:

UniProtKB/Swiss-Prot: EST3_HUMAN, Q6UWW8

Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low

catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a

prodrug for camptothecin used in cancer therapeutics

Catalytic activity: A carboxylic ester + H(2)O = an alcohol + a carboxylate

Biophysicochemical properties: Kinetic parameters: KM=137 uM for 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-

carbonyloxycamptothecin; KM=460 uM for 7-ethyl-10-[4-(1-piperidino)-1-amino]- carbonyloxycamptothecin;

Enzyme Numbers (IUBMB): EC 3.1.1.1¹ ² EC 3.1.1²

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CES3
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CES3:
		hsa-miR-645 hsa-miR-3714
		SwitchGear 3'UTR luciferase reporter plasmid: CES3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CES3 OriGene shRNA RFP: CES3 OriGene siRNA: CES3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CES3

Gene Editing
Products:

DNA2.0 Custom Protein Engineering Service for CES3

Clone Products:		Browse Clones for the Expression of Recombinant Proteins Available from EMD Millipore
		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CES3 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CES3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CES3 (NM_024922)
		Sino Biological Human cDNA Clone for CES3
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		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CES3

Cell Line Products:		GenScript Custom overexpressing Cell Line Services for CES3
		Search LifeMap BioReagents cell lines for CES3

In Situ Assay
Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CES3

Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6): About this table

GO ID	Qualified GO term	Evidence	PubMed IDs
GO:0004091	carboxylesterase activity	IBA	--
GO:0016787	hydrolase activity	--	--
GO:0050253	retinyl-palmitate esterase activity	IEA	--
GO:0080030	methyl indole-3-acetate esterase activity	IEA	--
GO:0080031	methyl salicylate esterase activity	IEA	--

CES3 for ontologies About GeneDecksing

2 GenomeRNAi human phenotypes for CES3:

Decreased viability with pacli

Increased G1 DNA content

Animal Models:
Mouse knock-out Ces1d^tm1Rile for CES3
5 MGI mutant phenotypes (inferred from 1 allele) (MGI details for Ces1d):

adipose tissue

behavior/neurological

endocrine/exocrine gland

homeostasis/metabolism

liver/biliary system

CES3 for phenotypes About GeneDecksing

(Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to ¹UniProtKB, ²MINT, ³I2D, and/or ⁴STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Mar 2013 via Entrez Gene).
About This Section

Unified GeneCards pathways About this table

See pathways by source

Super-pathway

contained gene-specific pathways

E2F transcription factor network

E2F transcription factor network

1.00

1 BioSystems Pathway for CES3

E2F transcription factor network

Interactions:

Search SABiosciences Gene Network Central^TM Interacting Genes and Proteins Networks for CES3

STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

5/7 Interacting proteins for CES3 (Q6UWW8³ ENSP00000304782⁴) via UniProtKB, MINT, STRING, and/or I2D (see all 7)

Interactant		Interaction Details
GeneCard	External ID(s)	Interaction Details
BMPR2	Q13873³, ENSP00000363708⁴	I2D: score=1 STRING: ENSP00000363708
CES1	ENSP00000353720⁴	STRING: ENSP00000353720
CES4A	ENSP00000381397⁴	STRING: ENSP00000381397
CES5A	ENSP00000290567⁴	STRING: ENSP00000290567
E2F1	ENSP00000345571⁴	STRING: ENSP00000345571

About this table

(Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
About This Section

Browse Small Molecules at EMD Millipore

Browse drugs & compounds from Enzo Life Sciences

Browse Tocris compounds for CES3

9 HMDB Compounds for CES3 About this table

Compound	Synonyms	CAS #	PubMed Ids
Arachidic acid	Arachate (see all 10)	506-30-9	--
Arachidonic acid	5,8,11,14-Eicosatetraenoic acid (see all 16)	506-32-1	--
Heptadecanoic acid	Heptadecanoate (see all 16)	506-12-7	--
Heptadecanoyl CoA	Heptadecanoyl coenzyme A (see all 19)	3546-17-6	--
Myristic acid	1-Tridecanecarboxylate (see all 15)	544-63-8	--
Palmitic acid	Hexaectylic acid (see all 45)	57-10-3	--
Pentadecanoic acid	Pentadecanoate (see all 8)	1002-84-2	--
Stearic acid	1-Heptadecanecarboxylate (see all 12)	57-11-4	--
Tridecanoic acid	(S)-2-Aminotridecanoate (see all 12)	638-53-9	--

Search CenterWatch for drugs/clinical trials and news about CES3 / EST3

(Secondary structures according to fRNAdb,
GenBank/EMBL/DDBJ Accessions according to
Unigene (Build 235 Homo sapiens; Mar 10 2013) or GenBank,
RefSeq according to Entrez Gene,
DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
RNAi Products from EMD Millipore,
siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, SABiosciences, and/or QIAGEN )
About This Section

REFSEQ mRNAs for CES3 gene (4 alternative transcripts):

NM_001185176.1 NM_001185177.1 NM_024922.5 NM_012122.1

Unigene Cluster for CES3:

Carboxylesterase 3

Hs.268700 [show with all ESTs]

Unigene Representative Sequence: NM_024922

8 Ensembl transcripts including schematic representations, and UCSC links where relevant:

ENST00000303334(uc002eqt.3 uc010cdz.3) ENST00000394037 ENST00000566453

ENST00000566746 ENST00000568118 ENST00000570236 ENST00000564715 ENST00000543856(uc010viw.2)

miRNA Products:		Browse 3'-UTR reporter clones for miRNA target validation Browse OriGene MicroRNA Expression Plasmids
		QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CES3
		2 QIAGEN miScript miRNA Assays for microRNAs that regulate CES3:
		hsa-miR-645 hsa-miR-3714
		SwitchGear 3'UTR luciferase reporter plasmid: CES3 3' UTR sequence

Inhib. RNA Products:		Browse for Gene Knock-down Tools from EMD Millipore
		OriGene 29mer shRNA kits in GFP-retroviral vector in human, mouse, rat for CES3 OriGene shRNA RFP: CES3 OriGene siRNA: CES3
		QIAGEN FlexiTube/FlexiPlate siRNA for gene silencing in human, mouse, rat CES3

Clone Products:		OriGene Myc/DDK tagged cDNA clones in CMV expression vector in human, mouse, rat for CES3 (see all 5) OriGene untagged cDNA clones in CMV expression vector in human, mouse, rat for CES3 OriGene custom cloning services � gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
		GenScript: all cDNA clones in your preferred vector (see all 3): CES3 (NM_024922)
		DNA2.0 Custom Codon Optimized Gene Synthesis Service for CES3
		Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CES3

Primer Products:		OriGene genome-wide validated SYBR primer pairs in human, mouse, rat for CES3 Browse OriGene validated miRNA SYBR primer pairs
		SABiosciences RT² qPCR Primer Assay in human, mouse, rat CES3
		QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CES3
		QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CES3

Additional cDNA sequence:

AK000105.1 AK025158.1 AK025171.1 AK025389.1 AY358609.1 BC053670.1

5 DOTS entries:

DT.101980426 DT.75128855 DT.92029825 DT.40251358 DT.120704429

GeneLoc Exon Structure

5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CES3 (see all 6) About this scheme

ExUns:	1a	·	1b	·	1c	^	2	^	3a	·	3b	·	3c	^	4a	·	4b	^	5	^	6	^	7a	·	7b	^	8	^	9	^	10	^	11a	·	11b	^	12	^	13a	·	13b	^	14a	·	14b	·	14c
SP1:															-														-										-
SP2:															-														-
SP3:											-		-																-
SP4:																													-		-		-		-
SP5:

ECgene alternative splicing isoforms for CES3

(RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
About This Section

CES3 expression in normal human tissues (normalized intensities)
See probesets specificity/sensitivity at GeneAnnot
About this imageBioGPS
CGAP TAG: CCTGACCCTC

About this image

CES3 expression in embryonic tissues and stem cells

Expression by the Database of Embryonic development, Stem cell research, and Regenerative medicine About this table

5 LifeMap In Vivo Development Anatomical Compartments/Cells

Tissue

Anatomical Compartment

Cell

Category (developmental path)

Adipose

Body Subcutaneous White Adipose

Adipose

Visceral White Adipose

Adipose

Bone

Head Mesenchyme

Liver

Expression:

Positive

Negative

Selective marker

Experimental details:

Curated

Microarrays

In-situ hybridization

See CES3 Protein Expression from SPIRE MOPED and PaxDB
Genevestigator expression for CES3

SOURCE GeneReport for Unigene cluster: Hs.268700

UniProtKB/Swiss-Prot: EST3_HUMAN, Q6UWW8

Tissue specificity: Expressed in liver, colon and small intestine

SABiosciences Expression via Pathway-Focused PCR Arrays including CES3:

Drug Metabolism: Phase II Enzymes in human mouse rat

Drug Metabolism in human mouse rat

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In Situ
Assay Products:

Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CES3

(Orthologs according to ^1,2HomoloGene (²older version, for species not in ¹newer version), ³euGenes, ⁴SGD , ⁵MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or ⁶Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
About This Section

This gene was present in the common ancestor of animals.

Orthologs for CES3 gene from 3/13 species (see all 13) About this table

Organism	Taxonomic classification	Gene	Description	Human Similarity	Orthology Type	Details
chicken (Gallus gallus)	Aves	CES3⁶	Uncharacterized protein	46(a)	1 ↔ 1	11(12031878-12044915)
zebrafish (Danio rerio)	Actinopterygii	ces3⁶ ces2⁶ (see all 3)	carboxylesterase 2 (intestine, liver) (see all 3)	41(a) 40(a) (see all 3)	many ↔ many many ↔ many (see all 3)	18(17077342-17085474) 18(17067638-17074777)
worm (Caenorhabditis elegans)	Secernentea	F15A8.6³	esterase	45(a) (best of 23)		X(4466430-4469785) --

ENSEMBL Gene Tree for CES3 (if available)
TreeFam Gene Tree for CES3 (if available)

(Paralogs according to ¹HomoloGene,
²Ensembl, and ³SIMAP, Pseudogenes according to ⁴Pseudogene.org Build 68)
About This Section

Paralogs for CES3 gene

NLGN1² CES2² ACHE² CES4A² NLGN4X² NLGN4Y² NLGN3² NLGN2²

CES1² CEL² BCHE² CES5A²

16 SIMAP similar genes for CES3 using alignment to 3 protein entries: EST3_HUMAN (see all proteins):

NLGN2 CES1P1 CES1 CES2 CES5A CES hBr2

CES8 TG CES4A DKFZp686F02202 ACHE NLGN3

CEL BCHE NLGN1 nlgn1

CES3 for paralogs About GeneDecksing

(SNPs/Variants according to the ¹NCBI SNP Database, ²Ensembl, ³PupaSUITE, UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
About This Section

SNP ID	Valid	Clinical significance	Chr 16 pos	Sequence	#	AA Chg	Type	More	#	Allele freq	Pop	Total sample	More
Genomic Data					Transcription Related Data				Allele Frequencies
				--	--	--		--	--
rs71647873^1,2	C,F,	--	66993252(+)	`GCAAGT/CGTAAA`	2	--	us2k¹		6		NS EA	274
rs183714334^1,2		--	66993286(+)	`GTGCCA/GACCCT`	2	--	us2k¹		0	--	--	--	--
rs188818182^1,2		--	66993353(+)	`TGCTGA/GCCTGT`	2	--	us2k¹		0	--	--	--	--
rs145124700^1,2		--	66993510(+)	`GTGGGC/TGGAGA`	2	--	us2k¹		0	--	--	--	--
rs201704858^1,2		--	66993748(+)	`ATGAA-/TTTTTT`	2	--	us2k¹		0	--	--	--	--
rs191764515^1,2		--	66993879(+)	`TGGCAC/GTAGTT`	2	--	us2k¹		0	--	--	--	--
rs149106023^1,2		--	66993976(+)	`GTGTTC/TAGGCA`	2	--	us2k¹		0	--	--	--	--
rs184540617^1,2		--	66993991(+)	`CCTCAC/TTCTGT`	2	--	us2k¹		0	--	--	--	--
rs188899452^1,2		--	66994053(+)	`CCAGCC/TATGTT`	2	--	us2k¹		0	--	--	--	--
rs68096928^1,2	C,F,	--	66994187(+)	`GTTCCC/TAGACT`	2	--	us2k¹		7		NS WA NA	428

HapMap Linkage Disequilibrium report for CES3 (66995132 - 67009052 bp)
Structural Variations (Copy Number Variations, Insertions/Deletions, Inversions)
Database of Genomic Variants (DGV) variations for CES3: --

SABiosciences Cancer Mutation PCR Assays

QIAGEN SeqTarget long-range PCR primers in human, mouse, rat for resequencing CES3

DNA2.0 Custom Variant and Variant Library Synthesis for CES3

(in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
About This Section

CES3 for disorders           About GeneDecksing

OMIM gene information: 605279    OMIM disorders: --

5 diseases for CES3:    About MalaCards

lymph node tuberculosis dental pulp necrosis cholesterol tuberculosis

alcoholism

1 disease from the University of Copenhagen DISEASES database for CES3:

Dental pulp necrosis

Human Genome Epidemiology (HuGE) Navigator: CES3 (1 document)

Export disorders for CES3 gene to outside databases

(in PubMed. Associations of this gene to articles via ¹Entrez Gene, ²UniProtKB/Swiss-Prot, ³HGNC, ⁴GAD, ⁵PharmGKB, ⁶HMDB, ⁷DrugBank, ⁸UniProtKB/TrEMBL, ⁹ Novoseek, and/or ¹⁰fRNAdb)
About This Section

PubMed articles for CES3 gene, integrated from 9 sources (see all 23):
(articles sorted by number of sources associating them with CES3)

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Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10- [4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. (PubMed id 15100172)^{1, 2, 3, 9} Sanghani S.P....Bosron W.F. (2004)
Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis. (PubMed id 14581373)^{1, 2, 3, 9} Sanghani S.P.... Bosron W.F. (2003)
Recommended nomenclature for five mammalian carboxyle sterase gene families: human, mouse, and rat genes and proteins. (PubMed id 20931200)^{1, 3} Holmes R.S....Maltais L.J. (2010)
Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)^{1, 2} Ota T.... Sugano S. (2004)
The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)^{1, 2} Clark H.F.... Gray A.M. (2003)
Human carboxylesterases: an update on CES1, CES2 and CES3. (PubMed id 19508181)^{1, 9} Sanghani S.P....Bosron W.F. (2009)
Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide. (PubMed id 15687373)^{2, 9} Quinney S.K.... Bosron W.F. (2005)
Mammalian carboxylesterase 3: comparative genomics an d proteomics. (PubMed id 20422440)^{1, 9} Holmes R.S....VandeBerg J.L. (2010)
Identification of a novel intracellular cholesteryl es ter hydrolase (carboxylesterase 3) in human macrophages: compensatory increase i n its expression after carboxylesterase 1 silencing. (PubMed id 22700792)¹ Zhao B....Ghosh S. (2012)
Evaluation of candidate genes for cholinesterase acti vity in farmworkers exposed to organophosphorus pesticides: association of sing le nucleotide polymorphisms in BCHE. (PubMed id 20529763)¹ Howard T.D....Arcury T.A. (2010)

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(According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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Entrez Gene: 23491	HGNC: 1865	Ensembl:ENSG00000172828	euGenes: HUgn23491	ECgene: CES3
H-InvDB: CES3

(According to HUGE)
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(According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
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Name	Description
PharmGKB entry for CES3	Pharmacogenomics, SNPs, Pathways
NIEHS-SNPs	http://egp.gs.washington.edu/data/ces3/

Intellectual Property for CES3 gene
(Patent information from GeneIP, Licensable technologies from WIS Yeda, Salk, Tufts, IP news from LifeMap Sciences, Inc.)

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Patent Information for CES3 gene:
Search GeneIP for patents involving CES3

GeneCards and IP:
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