Free for academic non-profit institutions. Other users need a Commercial license

Aliases for CES3 Gene

Aliases for CES3 Gene

  • Carboxylesterase 3 2 3
  • Liver Carboxylesterase 31 Homolog 3 4
  • Carboxylesterase 3 (Brain) 2 3
  • Esterase 31 2 3
  • EC 4 63
  • ES31 3 6
  • Brain Carboxylesterase BR3 2
  • EC 3.1.1 63

External Ids for CES3 Gene

Previous GeneCards Identifiers for CES3 Gene

  • GC16U990091
  • GC16P055532
  • GC16M055612
  • GC16M054394
  • GC16P065553
  • GC16P066995
  • GC16P052869

Summaries for CES3 Gene

Entrez Gene Summary for CES3 Gene

  • This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]

GeneCards Summary for CES3 Gene

CES3 (Carboxylesterase 3) is a Protein Coding gene. Diseases associated with CES3 include dental pulp necrosis. Among its related pathways are E2F transcription factor network. An important paralog of this gene is CES2.

UniProtKB/Swiss-Prot for CES3 Gene

  • Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics

Gene Wiki entry for CES3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CES3 Gene

Genomics for CES3 Gene

Regulatory Elements for CES3 Gene

Genomic Location for CES3 Gene

66,961,229 bp from pter
66,975,149 bp from pter
13,921 bases
Plus strand

Genomic View for CES3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CES3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CES3 Gene

Proteins for CES3 Gene

  • Protein details for CES3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Recommended name:
    Carboxylesterase 3
    Protein Accession:
    Secondary Accessions:
    • B2Z3W9
    • F5H242
    • Q7Z6J1
    • Q9H6X7

    Protein attributes for CES3 Gene

    571 amino acids
    Molecular mass:
    62282 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CES3 Gene


neXtProt entry for CES3 Gene

Proteomics data for CES3 Gene at MOPED

Selected DME Specific Peptides for CES3 Gene

Post-translational modifications for CES3 Gene

Other Protein References for CES3 Gene

Antibody Products

  • R&D Systems Antibodies for CES3 (Carboxylesterase 3/CES3)

Domains for CES3 Gene

Gene Families for CES3 Gene

Protein Domains for CES3 Gene

Suggested Antigen Peptide Sequences for CES3 Gene

GenScript: Design optimal peptide antigens:

Graphical View of Domain Structure for InterPro Entry



  • Belongs to the type-B carboxylesterase/lipase family.
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with CES3: view

Function for CES3 Gene

Molecular function for CES3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=137 uM for 7-ethyl-10-[4-(1-piperidino)-1-piperidino]- carbonyloxycamptothecin {ECO:0000269 PubMed:15100172}; KM=460 uM for 7-ethyl-10-[4-(1-piperidino)-1-amino]- carbonyloxycamptothecin {ECO:0000269 PubMed:15100172};
UniProtKB/Swiss-Prot CatalyticActivity:
A carboxylic ester + H(2)O = an alcohol + a carboxylate.
UniProtKB/Swiss-Prot Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics

Enzyme Numbers (IUBMB) for CES3 Gene

Gene Ontology (GO) - Molecular Function for CES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity --
GO:0052689 carboxylic ester hydrolase activity IBA --
genes like me logo Genes that share ontologies with CES3: view
genes like me logo Genes that share phenotypes with CES3: view

Animal Models for CES3 Gene

MGI Knock Outs for CES3:

Animal Model Products

CRISPR Products

miRNA for CES3 Gene

miRTarBase miRNAs that target CES3

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CES3

In Situ Assay Products

Flow Cytometry Products

No data available for Transcription Factor Targeting and HOMER Transcription for CES3 Gene

Localization for CES3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CES3 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

Jensen Localization Image for CES3 Gene COMPARTMENTS Subcellular localization image for CES3 gene
Compartment Confidence
endoplasmic reticulum 2
extracellular 2
cytosol 1
lysosome 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005783 endoplasmic reticulum --
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with CES3: view

Pathways for CES3 Gene

genes like me logo Genes that share pathways with CES3: view

Pathways by source for CES3 Gene

1 BioSystems pathway for CES3 Gene

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat
    • Drug Metabolism in human,mouse,rat

Interacting Proteins for CES3 Gene

Gene Ontology (GO) - Biological Process for CES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with CES3: view

Compounds for CES3 Gene

(9) HMDB Compounds for CES3 Gene

Compound Synonyms Cas Number PubMed IDs
Arachidic acid
  • Arachate
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
Heptadecanoic acid
  • Heptadecanoate
Heptadecanoyl CoA
  • Heptadecanoyl coenzyme A
Myristic acid
  • 1-Tridecanecarboxylate
genes like me logo Genes that share compounds with CES3: view

Transcripts for CES3 Gene

mRNA/cDNA for CES3 Gene

(6) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CES3 Gene

Carboxylesterase 3:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CES3

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CES3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - -

Relevant External Links for CES3 Gene

GeneLoc Exon Structure for
ECgene alternative splicing isoforms for

Expression for CES3 Gene

mRNA expression in normal human tissues for CES3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CES3 Gene

This gene is overexpressed in Colon - Transverse (15.5), Liver (9.4), and Muscle - Skeletal (6.0).

Protein differential expression in normal tissues for CES3 Gene

This gene is overexpressed in Milk (24.2), Colon (14.8), Stomach (12.2), and Gallbladder (10.1).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CES3 Gene

SOURCE GeneReport for Unigene cluster for CES3 Gene Hs.268700

mRNA Expression by UniProt/SwissProt for CES3 Gene

Tissue specificity: Expressed in liver, colon and small intestine.
genes like me logo Genes that share expressions with CES3: view

Expression partners for CES3 Gene

* - Elite partner

Primer Products

  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat

In Situ Assay Products

Orthologs for CES3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CES3 Gene

Organism Taxonomy Gene Similarity Type Details
(Bos Taurus)
Mammalia CES3 35
  • 79.82 (n)
  • 71.05 (a)
CES3 36
  • 71 (a)
(Mus musculus)
Mammalia Ces3b 35
  • 75.23 (n)
  • 67.52 (a)
Ces1d 16
Ces3a 36
  • 65 (a)
Ces3b 36
  • 66 (a)
(Pan troglodytes)
Mammalia CES3 35
  • 98.89 (n)
  • 97.9 (a)
CES3 36
  • 98 (a)
(Rattus norvegicus)
Mammalia Ces3a 35
  • 74.05 (n)
  • 61.15 (a)
(Monodelphis domestica)
Mammalia CES3 36
  • 51 (a)
(Ornithorhynchus anatinus)
Mammalia CES3 36
  • 52 (a)
(Danio rerio)
Actinopterygii ces2 36
  • 41 (a)
ces3 36
  • 41 (a)
si:ch211-93f2.1 36
  • 14 (a)
fruit fly
(Drosophila melanogaster)
Insecta alpha-Est10 37
  • 29 (a)
alpha-Est2 37
  • 30 (a)
alpha-Est3 37
  • 28 (a)
alpha-Est4 37
  • 38 (a)
alpha-Est6 37
  • 30 (a)
alpha-Est7 37
  • 30 (a)
alpha-Est8 37
  • 31 (a)
alpha-Est9 37
  • 28 (a)
BcDNA:GH05741 37
  • 30 (a)
CG10175 37
  • 29 (a)
CG10339 37
  • 26 (a)
CG3841 37
  • 34 (a)
CG4382 37
  • 28 (a)
CG5397 37
  • 28 (a)
CG6018 37
  • 30 (a)
CG6414 37
  • 29 (a)
CG7529 37
  • 26 (a)
CG8424 37
  • 42 (a)
CG9289 37
  • 27 (a)
clt 37
  • 31 (a)
Est-6 37
  • 27 (a)
Est-P 37
  • 29 (a)
Jhe 37
  • 30 (a)
(Caenorhabditis elegans)
Secernentea B0238.1 37
  • 31 (a)
B0238.13 37
  • 33 (a)
B0238.7 37
  • 29 (a)
C52A10.1 37
  • 31 (a)
C52A10.2 37
  • 31 (a)
F07C4.12 37
  • 30 (a)
F13H6.3 37
  • 30 (a)
F13H6.4 37
  • 29 (a)
F15A8.6 37
  • 45 (a)
F55D10.3 37
  • 27 (a)
ges-1 37
  • 28 (a)
K07C11.4 37
  • 28 (a)
K11G9.1 37
  • 41 (a)
K11G9.2 37
  • 27 (a)
R173.3 37
  • 37 (a)
T02B5.1 37
  • 26 (a)
T02B5.3 37
  • 27 (a)
T07H6.1a 37
  • 26 (a)
T28C12.4a 37
  • 29 (a)
T28C12.4b 37
  • 29 (a)
Y71H2AM.13 37
  • 30 (a)
Y75B8A.3 37
  • 36 (a)
ZC376.2 37
  • 24 (a)
Species with no ortholog for CES3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CES3 Gene

Gene Tree for CES3 (if available)
Gene Tree for CES3 (if available)

Paralogs for CES3 Gene

Paralogs for CES3 Gene

(16) SIMAP similar genes for CES3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CES3: view

Variants for CES3 Gene

Sequence variations from dbSNP and Humsavar for CES3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1211027 -- 66,968,302(-) ctgta(A/G)tccca intron-variant
rs1211028 -- 66,968,289(-) tactc(A/G)ggagg intron-variant
rs1308554 -- 66,968,464(-) CCAGg(A/G)ccggg intron-variant
rs1308555 -- 66,968,428(-) cattt(C/T)gggag intron-variant
rs3848288 -- 66,964,287(+) GCTAA(A/T)TCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CES3 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv827706 CNV Loss 20364138
nsv906791 CNV Loss 21882294
nsv906792 CNV Loss 21882294

Relevant External Links for CES3 Gene

HapMap Linkage Disequilibrium report

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CES3 Gene

Disorders for CES3 Gene

MalaCards: The human disease database

MalaCards: The human disease database.

Search for CES3 Gene in MalaCards »

(1) Disease for CES3 Gene

(1) University of Copenhagen DISEASES for CES3 Gene

Relevant External Links for CES3

Human Genome Epidemiology (HuGE) Navigator
genes like me logo Genes that share disorders with CES3: view

No data available for OMIM , UniProtKB/Swiss-Prot , Novoseek inferred disease relationships and Genatlas for CES3 Gene

Publications for CES3 Gene

  1. Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10- [4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. (PMID: 15100172) Sanghani S.P. … Bosron W.F. (Drug Metab. Dispos. 2004) 2 3 4 23
  2. Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis. (PMID: 14581373) Sanghani S.P. … Bosron W.F. (Clin. Cancer Res. 2003) 2 3 4 23
  3. Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide. (PMID: 15687373) Quinney S.K. … Bosron W.F. (J. Pharmacol. Exp. Ther. 2005) 4 23
  4. Human carboxylesterases: an update on CES1, CES2 and CES3. (PMID: 19508181) Sanghani S.P. … Bosron W.F. (Protein Pept. Lett. 2009) 3 23
  5. Mammalian carboxylesterase 3: comparative genomics and proteomics. (PMID: 20422440) Holmes R.S. … VandeBerg J.L. (Genetica 2010) 3 23

Products for CES3 Gene

Sources for CES3 Gene

Back to Top