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Aliases for CES3 Gene

Aliases for CES3 Gene

  • Carboxylesterase 3 2 3
  • Liver Carboxylesterase 31 Homolog 3 4
  • Carboxylesterase 3 (Brain) 2 3
  • Esterase 31 2 3
  • EC 3.1.1.1 4 64
  • ES31 3 6
  • Brain Carboxylesterase BR3 2
  • EC 3.1.1 64

External Ids for CES3 Gene

Summaries for CES3 Gene

Entrez Gene Summary for CES3 Gene

  • This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological validity and/or full-length nature of some variants have not been determined.[provided by RefSeq, Jun 2010]

GeneCards Summary for CES3 Gene

CES3 (Carboxylesterase 3) is a Protein Coding gene. Diseases associated with CES3 include dental pulp necrosis. Among its related pathways are E2F transcription factor network. An important paralog of this gene is CES2.

UniProtKB/Swiss-Prot for CES3 Gene

  • Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics

Gene Wiki entry for CES3 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CES3 Gene

Genomics for CES3 Gene

Genomic Location for CES3 Gene

Start:
66,961,229 bp from pter
End:
66,975,149 bp from pter
Size:
13,921 bases
Orientation:
Plus strand

Genomic View for CES3 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CES3 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CES3 Gene

Regulatory Elements for CES3 Gene

Proteins for CES3 Gene

  • Protein details for CES3 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    Q6UWW8-EST3_HUMAN
    Recommended name:
    Carboxylesterase 3
    Protein Accession:
    Q6UWW8
    Secondary Accessions:
    • B2Z3W9
    • F5H242
    • Q7Z6J1
    • Q9H6X7

    Protein attributes for CES3 Gene

    Size:
    571 amino acids
    Molecular mass:
    62282 Da
    Quaternary structure:
    No Data Available

    Alternative splice isoforms for CES3 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CES3 Gene

Proteomics data for CES3 Gene at MOPED

Selected DME Specific Peptides for CES3 Gene

Post-translational modifications for CES3 Gene

Other Protein References for CES3 Gene

Domains for CES3 Gene

Gene Families for CES3 Gene

HGNC:
  • CES :Carboxylesterases

Protein Domains for CES3 Gene

UniProtKB/Swiss-Prot:

EST3_HUMAN
Family:
  • Belongs to the type-B carboxylesterase/lipase family.:
    • Q6UWW8
genes like me logo Genes that share domains with CES3: view

Function for CES3 Gene

Molecular function for CES3 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=137 uM for 7-ethyl-10-[4-(1-piperidino)-1-piperidino]- carbonyloxycamptothecin {ECO:0000269 PubMed:15100172}; KM=460 uM for 7-ethyl-10-[4-(1-piperidino)-1-amino]- carbonyloxycamptothecin {ECO:0000269 PubMed:15100172};
UniProtKB/Swiss-Prot CatalyticActivity: A carboxylic ester + H(2)O = an alcohol + a carboxylate.
UniProtKB/Swiss-Prot Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows low catalytic efficiency for hydrolysis of CPT-11 (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer therapeutics

Enzyme Numbers (IUBMB) for CES3 Gene

Gene Ontology (GO) - Molecular Function for CES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity --
GO:0052689 carboxylic ester hydrolase activity IBA --
genes like me logo Genes that share ontologies with CES3: view
genes like me logo Genes that share phenotypes with CES3: view

Animal Models for CES3 Gene

MGI Knock Outs for CES3:

miRNA for CES3 Gene

miRTarBase miRNAs that target CES3

No data available for Transcription Factor Targeting and HOMER Transcription for CES3 Gene

Localization for CES3 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CES3 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CES3 Gene COMPARTMENTS Subcellular localization image for CES3 gene
Compartment Confidence
endoplasmic reticulum 2
extracellular 2
cytosol 1
lysosome 1
nucleus 1
plasma membrane 1

Gene Ontology (GO) - Cellular Components for CES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005783 endoplasmic reticulum --
GO:0005788 endoplasmic reticulum lumen IEA --
GO:0070062 extracellular exosome IDA 19199708
genes like me logo Genes that share ontologies with CES3: view

Pathways for CES3 Gene

genes like me logo Genes that share pathways with CES3: view

Pathways by source for CES3 Gene

1 BioSystems pathway for CES3 Gene

Interacting Proteins for CES3 Gene

Gene Ontology (GO) - Biological Process for CES3 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process IEA --
genes like me logo Genes that share ontologies with CES3: view

Compounds for CES3 Gene

(9) HMDB Compounds for CES3 Gene

Compound Synonyms Cas Number PubMed IDs
Arachidic acid
  • Arachate
506-30-9
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
Heptadecanoic acid
  • Heptadecanoate
506-12-7
Heptadecanoyl CoA
  • Heptadecanoyl coenzyme A
3546-17-6
Myristic acid
  • 1-Tridecanecarboxylate
544-63-8
genes like me logo Genes that share compounds with CES3: view

Transcripts for CES3 Gene

mRNA/cDNA for CES3 Gene

(6) REFSEQ mRNAs :
(6) Additional mRNA sequences :
(8) Ensembl transcripts including schematic representations, and UCSC links where relevant :

Unigene Clusters for CES3 Gene

Carboxylesterase 3:
Representative Sequences:

Alternative Splicing Database (ASD) splice patterns (SP) for CES3 Gene

ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
SP1: - - -
SP2: - -
SP3: - - -
SP4: - - - -
SP5:
SP6:

Relevant External Links for CES3 Gene

GeneLoc Exon Structure for
CES3
ECgene alternative splicing isoforms for
CES3

Expression for CES3 Gene

mRNA expression in normal human tissues for CES3 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CES3 Gene

This gene is overexpressed in Colon - Transverse (15.5), Liver (9.4), and Muscle - Skeletal (6.0).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CES3 Gene

SOURCE GeneReport for Unigene cluster for CES3 Gene Hs.268700

mRNA Expression by UniProt/SwissProt for CES3 Gene

Q6UWW8-EST3_HUMAN
Tissue specificity: Expressed in liver, colon and small intestine.
genes like me logo Genes that share expressions with CES3: view

Orthologs for CES3 Gene

This gene was present in the common ancestor of animals.

Orthologs for CES3 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CES3 36
  • 98.89 (n)
  • 97.9 (a)
CES3 37
  • 98 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CES3 36
  • 79.82 (n)
  • 71.05 (a)
CES3 37
  • 71 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ces1d 16
Ces3a 37
  • 65 (a)
OneToMany
Ces3b 36
  • 75.23 (n)
  • 67.52 (a)
Ces3b 37
  • 66 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia CES3 37
  • 51 (a)
OneToOne
platypus
(Ornithorhynchus anatinus)
Mammalia CES3 37
  • 52 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ces3a 36
  • 74.05 (n)
  • 61.15 (a)
zebrafish
(Danio rerio)
Actinopterygii ces2 37
  • 41 (a)
ManyToMany
ces3 37
  • 41 (a)
ManyToMany
si:ch211-93f2.1 37
  • 14 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7529 38
  • 26 (a)
alpha-Est2 38
  • 30 (a)
Est-6 38
  • 27 (a)
CG6414 38
  • 29 (a)
alpha-Est8 38
  • 31 (a)
CG9289 38
  • 27 (a)
CG6018 38
  • 30 (a)
CG3841 38
  • 34 (a)
CG4382 38
  • 28 (a)
alpha-Est6 38
  • 30 (a)
alpha-Est3 38
  • 28 (a)
CG8424 38
  • 42 (a)
CG5397 38
  • 28 (a)
CG10175 38
  • 29 (a)
BcDNA:GH05741 38
  • 30 (a)
Est-P 38
  • 29 (a)
CG10339 38
  • 26 (a)
Jhe 38
  • 30 (a)
alpha-Est10 38
  • 29 (a)
alpha-Est4 38
  • 38 (a)
alpha-Est9 38
  • 28 (a)
clt 38
  • 31 (a)
alpha-Est7 38
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea F55D10.3 38
  • 27 (a)
K11G9.1 38
  • 41 (a)
ZC376.2 38
  • 24 (a)
T02B5.3 38
  • 27 (a)
F15A8.6 38
  • 45 (a)
C52A10.2 38
  • 31 (a)
Y75B8A.3 38
  • 36 (a)
B0238.13 38
  • 33 (a)
T28C12.4a 38
  • 29 (a)
F13H6.4 38
  • 29 (a)
K11G9.2 38
  • 27 (a)
R173.3 38
  • 37 (a)
ges-1 38
  • 28 (a)
B0238.7 38
  • 29 (a)
B0238.1 38
  • 31 (a)
T28C12.4b 38
  • 29 (a)
Y71H2AM.13 38
  • 30 (a)
K07C11.4 38
  • 28 (a)
C52A10.1 38
  • 31 (a)
T02B5.1 38
  • 26 (a)
F07C4.12 38
  • 30 (a)
T07H6.1a 38
  • 26 (a)
F13H6.3 38
  • 30 (a)
Species with no ortholog for CES3:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • dog (Canis familiaris)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • lizard (Anolis carolinensis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CES3 Gene

ENSEMBL:
Gene Tree for CES3 (if available)
TreeFam:
Gene Tree for CES3 (if available)

Paralogs for CES3 Gene

Paralogs for CES3 Gene

Selected SIMAP similar genes for CES3 Gene using alignment to 3 proteins:

genes like me logo Genes that share paralogs with CES3: view

Variants for CES3 Gene

Sequence variations from dbSNP and Humsavar for CES3 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1211027 -- 66,968,302(-) ctgta(A/G)tccca intron-variant
rs1211028 -- 66,968,289(-) tactc(A/G)ggagg intron-variant
rs1308554 -- 66,968,464(-) CCAGg(A/G)ccggg intron-variant
rs1308555 -- 66,968,428(-) cattt(C/T)gggag intron-variant
rs3848288 -- 66,964,287(+) GCTAA(A/T)TCAAA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CES3 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv827706 CNV Loss 20364138
nsv906791 CNV Loss 21882294
nsv906792 CNV Loss 21882294

Relevant External Links for CES3 Gene

HapMap Linkage Disequilibrium report
CES3

Disorders for CES3 Gene

(1) MalaCards Diseases for CES3 Gene

Search for CES3 Gene in MalaCards »

(1) University of Copenhagen DISEASES for CES3 Gene

Relevant External Links for CES3

Human Genome Epidemiology (HuGE) Navigator
CES3
genes like me logo Genes that share disorders with CES3: view

No data available for UniProtKB/Swiss-Prot for CES3 Gene

Publications for CES3 Gene

  1. Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10- [4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. (PMID: 15100172) Sanghani S.P. … Bosron W.F. (Drug Metab. Dispos. 2004) 2 3 4 23
  2. Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis. (PMID: 14581373) Sanghani S.P. … Bosron W.F. (Clin. Cancer Res. 2003) 2 3 4 23
  3. Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide. (PMID: 15687373) Quinney S.K. … Bosron W.F. (J. Pharmacol. Exp. Ther. 2005) 4 23
  4. Human carboxylesterases: an update on CES1, CES2 and CES3. (PMID: 19508181) Sanghani S.P. … Bosron W.F. (Protein Pept. Lett. 2009) 3 23
  5. Mammalian carboxylesterase 3: comparative genomics and proteomics. (PMID: 20422440) Holmes R.S. … VandeBerg J.L. (Genetica 2010) 3 23

Products for CES3 Gene

Sources for CES3 Gene

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