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CES3 Gene

protein-coding   GIFtS: 61
GCID: GC16P066995

Carboxylesterase 3

(Previous name: carboxylesterase 3 (brain))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carboxylesterase 31 2     EC 3.1.1.13 8
Carboxylesterase 3 (Brain)1 2     ES312 5
Esterase 311 2     Brain Carboxylesterase BR31
Liver Carboxylesterase 31 Homolog2 3     EC 3.1.18

External Ids:    HGNC: 18651   Entrez Gene: 234912   Ensembl: ENSG000001728287   OMIM: 6052795   UniProtKB: Q6UWW83   

Export aliases for CES3 gene to outside databases

Previous GC identifers: GC16U990091 GC16P055532 GC16M055612 GC16M054394 GC16P065553 GC16P052869


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CES3 Gene:
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the
hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates
with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and
may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in
colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple
alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological
validity and/or full-length nature of some variants have not been determined.(provided by RefSeq, Jun 2010)

GeneCards Summary for CES3 Gene:
CES3 (carboxylesterase 3) is a protein-coding gene. Diseases associated with CES3 include dental pulp necrosis, and lymph node tuberculosis. GO annotations related to this gene include . An important paralog of this gene is NLGN1.

UniProtKB/Swiss-Prot: EST3_HUMAN, Q6UWW8
Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows
low catalytic efficiency for hydrolysis of CPT-11
(7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer
therapeutics

Gene Wiki entry for CES3 (Carboxylesterase 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence:
NC_000016.10  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CES3 gene promoter:
         GR   HEN1   Pax-3   AML1a   GR-alpha   NF-kappaB1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCES3 promoter sequence
   Search Chromatin IP Primers for CES3

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CES3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

CES3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CES3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P066995:  view genomic region     (about GC identifiers)

Start:
66,995,132 bp from pter      End:
67,009,052 bp from pter
Size:
13,921 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EST3_HUMAN, Q6UWW8 (See protein sequence)
Recommended Name: Carboxylesterase 3 precursor  
Size: 571 amino acids; 62282 Da
Secondary accessions: B2Z3W9 F5H242 Q7Z6J1 Q9H6X7
Alternative splicing: 2 isoforms:  Q6UWW8-1   Q6UWW8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CES3: NX_Q6UWW8

Explore proteomics data for CES3 at MOPED

Post-translational modifications: 

  • N-glycosylated1
  • Glycosylation2 at Asn105
  • Modification sites at PhosphoSitePlus
  • Selected DME Specific Peptides for CES3 (Q6UWW8) (see all 5)
     GFFSTGD  AALRWVQ  FLGIPFA  FARTGDPN 


    See CES3 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (3 alternative transcripts): 
    NP_001172105.1  NP_001172106.1  NP_079198.2  

    ENSEMBL proteins: 
     ENSP00000304782   ENSP00000377602   ENSP00000456203   ENSP00000457547   ENSP00000445559  

    CES3 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
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    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Protein for CES3
    OriGene Protein Over-expression Lysate for CES3
    OriGene MassSpec for CES3
    OriGene Custom Protein Services for CES3
    GenScript Custom Purified and Recombinant Proteins Services for CES3
    Novus Biologicals CES3 Protein
    Novus Biologicals CES3 Lysates
    Sino Biological Recombinant Protein for CES3
    Browse Sino Biological Cell Lysates
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CES3

    CES3 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CES3 (Carboxylesterase 3/CES3)
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    Novus Biologicals CES3 Antibodies
    Abcam antibodies for CES3
    Cloud-Clone Corp. Antibodies for CES3
    ThermoFisher Antibodies for CES3
    LSBio Antibodies in human, mouse, rat for CES3

    CES3 Assay Products:

    Browse Kits and Assays available from EMD Millipore
    OriGene Custom Assay Services for CES3
    Browse R&D Systems for biochemical assays
    GenScript Custom Assay Services for CES3
    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CES3
    Cloud-Clone Corp. CLIAs for CES3


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CES: Carboxylesterases

    2 InterPro protein domains:
     IPR019826 Carboxylesterase_B_AS
     IPR002018 CarbesteraseB

    Graphical View of Domain Structure for InterPro Entry Q6UWW8

    ProtoNet protein and cluster: Q6UWW8

    UniProtKB/Swiss-Prot: EST3_HUMAN, Q6UWW8
    Similarity: Belongs to the type-B carboxylesterase/lipase family


    CES3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, and Vector BioLabs, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EST3_HUMAN, Q6UWW8
    Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows
    low catalytic efficiency for hydrolysis of CPT-11
    (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer
    therapeutics
    Catalytic activity: A carboxylic ester + H(2)O = an alcohol + a carboxylate
    Biophysicochemical properties: Kinetic parameters: KM=137 uM for 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-
    carbonyloxycamptothecin; KM=460 uM for 7-ethyl-10-[4-(1-piperidino)-1-amino]- carbonyloxycamptothecin;

         Enzyme Numbers (IUBMB): EC 3.1.1.11 2 EC 3.1.12

         Gene Ontology (GO): 2 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity ----
    GO:0052689carboxylic ester hydrolase activity IEA--
         
    CES3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CES3:
     Decreased viability with pacli  Increased G1 DNA content 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ces1d):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  homeostasis/metabolism  liver/biliary system 

    CES3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ces1dtm1Rile for CES3

       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CES3
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CES3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CES3
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CES3

    miRNA
    Products:
        
    miRTarBase miRNAs that target CES3:
    hsa-mir-26b-5p (MIRT030333)

    Block miRNA regulation of human, mouse, rat CES3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CES3:
    hsa-miR-645 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidCES3 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CES3
    Predesigned siRNA for gene silencing in human, mouse, rat CES3

    Gene Editing
    Products:
    DNA2.0 Custom Protein Engineering Service for CES3

    Clone
    Products:
         
    OriGene clones in human, mouse for CES3 (see all 11)
    OriGene ORF clones in mouse, rat for CES3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CES3 (NM_024922)
    Browse Sino Biological Human cDNA Clones
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CES3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CES3

    Cell Line
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    GenScript Custom overexpressing Cell Line Services for CES3
    Browse ESI BIO Cell Lines and PureStem Progenitors for CES3 
    In Situ Assay
    Products:
       

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CES3


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EST3_HUMAN, Q6UWW8: Endoplasmic reticulum lumen (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum2
    extracellular2
    cytosol1
    lysosome1
    nucleus1
    plasma membrane1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005788endoplasmic reticulum lumen IEA--
    GO:0070062extracellular vesicular exosome IDA19199708

    CES3 for ontologies           About GeneDecksing


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CES3 About    
    See pathways by source

    SuperPathContained pathways About
    1E2F transcription factor network
    E2F transcription factor network


    1 BioSystems Pathway for CES3
        E2F transcription factor network



        Pathway & Disease-focused RT2 Profiler PCR Arrays including CES3: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        Search GeneGlobe Interaction Network for CES3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    Selected Interacting proteins for CES3 (Q6UWW83 ENSP000003047824) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMPR2Q138733, ENSP000003637084I2D: score=1 STRING: ENSP00000363708
    CES1ENSP000003537204STRING: ENSP00000353720
    CES4AENSP000003813974STRING: ENSP00000381397
    CES5AENSP000002905674STRING: ENSP00000290567
    E2F1ENSP000003455714STRING: ENSP00000345571
    About this table

    Gene Ontology (GO): 1 biological process term:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----

    CES3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CES3 (EST3)

    9 HMDB Compounds for CES3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
    Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
    Myristic acid1-Tridecanecarboxylate (see all 15)544-63-8--
    Palmitic acidHexaectylic acid (see all 45)57-10-3--
    Pentadecanoic acidPentadecanoate (see all 8)1002-84-2--
    Stearic acid1-Heptadecanecarboxylate (see all 12)57-11-4--
    Tridecanoic acid(S)-2-Aminotridecanoate (see all 12)638-53-9--



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, Primers from OriGene, and/or QIAGEN )
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    REFSEQ mRNAs for CES3 gene (4 alternative transcripts): 
    NM_001185176.1  NM_001185177.1  NM_024922.5  NM_012122.1  

    Unigene Cluster for CES3:

    Carboxylesterase 3
    Hs.268700  [show with all ESTs]
    Unigene Representative Sequence: NM_024922
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303334(uc002eqt.3 uc010cdz.3) ENST00000394037 ENST00000566453
    ENST00000566746 ENST00000568118 ENST00000570236 ENST00000564715 ENST00000543856(uc010viw.2)

    miRNA
    Products:
         
    Block miRNA regulation of human, mouse, rat CES3 using miScript Target Protectors
    2 qRT-PCR Assays for microRNAs that regulate CES3:
    hsa-miR-645 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidCES3 3' UTR sequence
    Inhib. RNA
    Products:
         
    OriGene RNAi products in human, mouse, rat for CES3
    Predesigned siRNA for gene silencing in human, mouse, rat CES3
    Clone
    Products:
         
    OriGene clones in human, mouse for CES3 (see all 11)
    OriGene ORF clones in mouse, rat for CES3
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 3): CES3 (NM_024922)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CES3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CES3
    Primer
    Products:
        
    OriGene qSTAR qPCR primer pairs in human, mouse for CES3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CES3
      QuantiTect SYBR Green Assays in human, mouse, rat CES3
      QuantiFast Probe-based Assays in human, mouse, rat CES3

    Additional mRNA sequence: 

    AK000105.1 AK025158.1 AK025171.1 AK025389.1 AY358609.1 BC053670.1 

    5 DOTS entries:

    DT.101980426  DT.75128855  DT.92029825  DT.40251358  DT.120704429 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CES3 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
    SP1:                                            -                                         -                             -                           
    SP2:                                            -                                         -                                                         
    SP3:                                -     -                                               -                                                         
    SP4:                                                                                      -     -     -     -                                       
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for CES3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CES3 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGACCCTC
    CES3 Expression
    About this image


    CES3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Liver (Hepatobiliary System)    fully expand to see all 3 entries
             Hepatocytes Liver Lobule
             Liver Lobule
     
     Lung (Respiratory System)    fully expand to see all 2 entries
             Stem Bronchi
     
     Adipose (Muscoskeletal System)    fully expand to see all 2 entries
             Body Subcutaneous White Adipose
     
     Epithelial Cells
             Duct Cells Pancreatic Ducts
    CES3 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CES3 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.268700

    UniProtKB/Swiss-Prot: EST3_HUMAN, Q6UWW8
    Tissue specificity: Expressed in liver, colon and small intestine

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CES3: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
    Products:
    OriGene qSTAR qPCR primer pairs in human, mouse for CES3
    Pre-validated RT2 qPCR Primer Assay in human, mouse, rat CES3
    QuantiTect SYBR Green Assays in human, mouse, rat CES3
    QuantiFast Probe-based Assays in human, mouse, rat CES3
    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CES3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CES3 gene from Selected species (see all 9)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ces1d5
    Ces3b1
    carboxylesterase 1D5
    carboxylesterase 3B1
    75.23(n)1
    67.52(a)1
      8 (45.05 cM)5
    139091  NM_144511.21  NP_653094.21 
     931660685 
    zebrafish
    (Danio rerio)
    Actinopterygii ces26
    ces36
    (see all 3)
    carboxylesterase 3
    (see all 3)
    41(a)
    41(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    18(17067638-17074777) ENSDARG00000041569
    18(17077342-17085474) ENSDARG00000041595


    ENSEMBL Gene Tree for CES3 (if available)
    TreeFam Gene Tree for CES3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CES3 gene
    NLGN12  CES22  ACHE2  CES4A2  NLGN4X2  NLGN4Y2  NLGN32  NLGN22  
    CES12  CEL2  CES5A2  BCHE2  
    16 SIMAP similar genes for CES3 using alignment to 3 protein entries:     EST3_HUMAN (see all proteins):
    NLGN2    CES1P1    CES5A    CES1    CES2    CES hBr2
    CES8    TG    CES4A    DKFZp686F02202    NLGN3    ACHE
    CEL    BCHE    NLGN1    nlgn1

    CES3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CES3 (see all 419)    About this table    
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs716478731,2
    C,F--66993252(+) GCAAGT/CGTAAA 2 -- us2k16Minor allele frequency- C:0.03NS EA 274
    rs1837143341,2
    --66993286(+) GTGCCA/GACCCT 2 -- us2k10--------
    rs1888181821,2
    --66993353(+) TGCTGA/GCCTGT 2 -- us2k10--------
    rs1451247001,2
    --66993510(+) GTGGGC/TGGAGA 2 -- us2k10--------
    rs2017048581,2
    --66993748(+) ATGAA-/TTTTTT 2 -- us2k10--------
    rs1917645151,2
    --66993879(+) TGGCAC/GTAGTT 2 -- us2k10--------
    rs1491060231,2
    --66993976(+) GTGTTC/TAGGCA 2 -- us2k10--------
    rs1845406171,2
    --66993991(+) CCTCAC/TTCTGT 2 -- us2k10--------
    rs1888994521,2
    --66994053(+) CCAGCC/TATGTT 2 -- us2k10--------
    rs680969281,2
    C,F--66994187(+) GTTCCC/TAGACT 2 -- us2k17Minor allele frequency- T:0.17NS WA NA 428

    HapMap Linkage Disequilibrium report for CES3 (66995132 - 67009052 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CES3:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv906791CNV Loss21882294
    nsv906792CNV Loss21882294
    dgv2885n71CNV Loss21882294
    nsv827706CNV Loss20364138

    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CES3
    DNA2.0 Custom Variant and Variant Library Synthesis for CES3

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605279    OMIM disorders: --

    5 diseases for CES3:    
    About MalaCards
    dental pulp necrosis    lymph node tuberculosis    tuberculosis    pancreatitis
    hepatitis

    1 disease from the University of Copenhagen DISEASES database for CES3:
    Dental pulp necrosis

    CES3 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: CES3 (1 document)

    Export disorders for CES3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

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    PubMed articles for CES3 gene, integrated from 10 sources (see all 24):
    (articles sorted by number of sources associating them with CES3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10- [4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. (PubMed id 15100172)1, 2, 3, 9 Sanghani S.P....Bosron W.F. (Drug Metab. Dispos. 2004)
    2. Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis. (PubMed id 14581373)1, 2, 3, 9 Sanghani S.P.... Bosron W.F. (Clin. Cancer Res. 2003)
    3. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. (PubMed id 20931200)1, 3 Holmes R.S....Maltais L.J. (Mamm. Genome 2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (Nat. Genet. 2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (Genome Res. 2003)
    6. Human carboxylesterases: an update on CES1, CES2 and CES3. (PubMed id 19508181)1, 9 Sanghani S.P....Bosron W.F. (Protein Pept. Lett. 2009)
    7. Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide. (PubMed id 15687373)2, 9 Quinney S.K.... Bosron W.F. (J. Pharmacol. Exp. Ther. 2005)
    8. Mammalian carboxylesterase 3: comparative genomics and proteomics. (PubMed id 20422440)1, 9 Holmes R.S....VandeBerg J.L. (Genetica 2010)
    9. Identification of a novel intracellular cholesteryl ester hydrolase (carboxylesterase 3) in human macrophages: compensatory increase in its expression after carboxylesterase 1 silencing. (PubMed id 22700792)1 Zhao B....Ghosh S. (Am. J. Physiol., Cell Physiol. 2012)
    10. Evaluation of candidate genes for cholinesterase activity in farmworkers exposed to organophosphorus pesticides: association of single nucleotide polymorphisms in BCHE. (PubMed id 20529763)1 Howard T.D....Arcury T.A. (Environ. Health Perspect. 2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 23491 HGNC: 1865 Ensembl:ENSG00000172828 euGenes: HUgn23491 ECgene: CES3
    H-InvDB: CES3

    (According to HUGE)
    About This Section

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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
    About This Section

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    NameDescription
    PharmGKB entry for CES3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ces3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section

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    Patent Information for CES3 gene:
    Search GeneIP for patents involving CES3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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