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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CES3 Gene

protein-coding   GIFtS: 60
GCID: GC16P066995

Carboxylesterase 3

(Previous name: carboxylesterase 3 (brain))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

Aliases
Carboxylesterase 31 2     EC 3.1.1.13 8
Carboxylesterase 3 (Brain)1 2     ES312 5
Esterase 311 2     Brain Carboxylesterase BR31
Liver Carboxylesterase 31 Homolog2 3     EC 3.1.18

External Ids:    HGNC: 18651   Entrez Gene: 234912   Ensembl: ENSG000001728287   OMIM: 6052795   UniProtKB: Q6UWW83   

Export aliases for CES3 gene to outside databases

Previous GC identifers: GC16U990091 GC16P055532 GC16M055612 GC16M054394 GC16P065553 GC16P052869


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CES3 Gene:
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the
hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates
with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and
may play a role in the blood-brain barrier system. This gene is expressed in several tissues, particularly in
colon, trachea and in brain, and the protein participates in colon and neural drug metabolism. Multiple
alternatively spliced transcript variants encoding distinct isoforms have been reported, but the biological
validity and/or full-length nature of some variants have not been determined.(provided by RefSeq, Jun 2010)

GeneCards Summary for CES3 Gene: 
CES3 (carboxylesterase 3) is a protein-coding gene. Diseases associated with CES3 include dental pulp necrosis, and lymph node tuberculosis. GO annotations related to this gene include carboxylesterase activity and methyl indole-3-acetate esterase activity. An important paralog of this gene is NLGN1.

UniProtKB/Swiss-Prot: EST3_HUMAN, Q6UWW8
Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows
low catalytic efficiency for hydrolysis of CPT-11
(7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer
therapeutics

Gene Wiki entry for CES3 (Carboxylesterase 3) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CES3 gene promoter:
         GR   HEN1   Pax-3   AML1a   GR-alpha   NF-kappaB1   C/EBPalpha   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCES3 promoter sequence
   Search SABiosciences Chromatin IP Primers for CES3

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CES3


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

CES3 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CES3 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P066995:  view genomic region     (about GC identifiers)

Start:
66,995,132 bp from pter      End:
67,009,052 bp from pter
Size:
13,921 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EST3_HUMAN, Q6UWW8 (See protein sequence)
Recommended Name: Carboxylesterase 3 precursor  
Size: 571 amino acids; 62282 Da
Subcellular location: Endoplasmic reticulum lumen (By similarity)
Secondary accessions: B2Z3W9 F5H242 Q7Z6J1 Q9H6X7
Alternative splicing: 2 isoforms:  Q6UWW8-1   Q6UWW8-2   (No experimental confirmation available)

Explore the universe of human proteins at neXtProt for CES3: NX_Q6UWW8

Explore proteomics data for CES3 at MOPED 

Post-translational modifications:

  • UniProtKB: N-glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_Q6UWW8

  • 4/5 DME Specific Peptides for CES3 (Q6UWW8) (see all 5)
     GFFSTGD  AALRWVQ  FLGIPFA  FARTGDPN 

    CES3 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CES3 Protein Expression
    REFSEQ proteins (3 alternative transcripts): 
    NP_001172105.1  NP_001172106.1  NP_079198.2  

    ENSEMBL proteins: 
     ENSP00000304782   ENSP00000377602   ENSP00000456203   ENSP00000457547   ENSP00000445559  

    Human Recombinant Protein Products for CES3: 
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    Novus Biologicals CES3 Protein
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    Sino Biological Recombinant Protein for CES3
    Sino Biological Cell Lysate for CES3 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CES3 

    Gene Ontology (GO): 1 cellular component term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005788endoplasmic reticulum lumen IEA--

    CES3 for ontologies           About GeneDecksing



    CES3 Antibody Products: 
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    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CES: Carboxylesterases

    2 InterPro protein domains:
     IPR019826 Carboxylesterase_B_AS
     IPR002018 CarbesteraseB

    Graphical View of Domain Structure for InterPro Entry Q6UWW8

    ProtoNet protein and cluster: Q6UWW8

    UniProtKB/Swiss-Prot: EST3_HUMAN, Q6UWW8
    Similarity: Belongs to the type-B carboxylesterase/lipase family


    CES3 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EST3_HUMAN, Q6UWW8
    Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows
    low catalytic efficiency for hydrolysis of CPT-11
    (7-ethyl-10-[4-(1-piperidino)-1-piperidino]-carbonyloxycamptothecin), a prodrug for camptothecin used in cancer
    therapeutics
    Catalytic activity: A carboxylic ester + H(2)O = an alcohol + a carboxylate
    Biophysicochemical properties: Kinetic parameters: KM=137 uM for 7-ethyl-10-[4-(1-piperidino)-1-piperidino]-
    carbonyloxycamptothecin; KM=460 uM for 7-ethyl-10-[4-(1-piperidino)-1-amino]- carbonyloxycamptothecin;

         Enzyme Numbers (IUBMB): EC 3.1.1.11 2 EC 3.1.12

         Gene Ontology (GO): 5/6 molecular function terms (GO ID links to tree view) (see all 6):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004091carboxylesterase activity IBA--
    GO:0016787hydrolase activity ----
    GO:0050253retinyl-palmitate esterase activity ----
    GO:0080030methyl indole-3-acetate esterase activity ----
    GO:0080031methyl salicylate esterase activity ----
         
    CES3 for ontologies           About GeneDecksing


    Phenotypes:
         2 GenomeRNAi human phenotypes for CES3:
     Decreased viability with pacli  Increased G1 DNA content 

         5 MGI mutant phenotypes (inferred from 1 allele(MGI details for Ces1d):
     adipose tissue  behavior/neurological  endocrine/exocrine gland  homeostasis/metabolism  liver/biliary system 

    CES3 for phenotypes           About GeneDecksing

    Animal Models:
         MGI mouse knock-out Ces1dtm1Rile for CES3

       inGenious Targeting Laboratory - Custom generated mouse model solutions for CES3 
       inGenious Targeting Laboratory - Custom generated inducible mouse model solutions for CES3

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CES3 
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CES3 

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CES3
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CES3:
    hsa-miR-645 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidCES3 3' UTR sequence
    Inhib. RNA
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CES3


    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CES3 About                                                                                                See pathways by source

    SuperPathContained pathways About
    1E2F transcription factor network
    E2F transcription factor network


    1 BioSystems Pathway for CES3
        E2F transcription factor network



    Interactions:

        Search SABiosciences Gene Network CentralTM Interacting Genes and Proteins Networks for CES3

    STRING Interaction Network Preview (showing 5 interactants - click image to see 7)

    5/7 Interacting proteins for CES3 (Q6UWW83 ENSP000003047824) via UniProtKB, MINT, STRING, and/or I2D (see all 7)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    BMPR2Q138733, ENSP000003637084I2D: score=1 STRING: ENSP00000363708
    CES1ENSP000003537204STRING: ENSP00000353720
    CES4AENSP000003813974STRING: ENSP00000381397
    CES5AENSP000002905674STRING: ENSP00000290567
    E2F1ENSP000003455714STRING: ENSP00000345571
    About this table

    Gene Ontology (GO): 1 biological process term (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----

    CES3 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section
    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CES3 (EST3)

    9 HMDB Compounds for CES3    About this table
    CompoundSynonyms CAS #PubMed Ids
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
    Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
    Myristic acid1-Tridecanecarboxylate (see all 15)544-63-8--
    Palmitic acidHexaectylic acid (see all 45)57-10-3--
    Pentadecanoic acidPentadecanoate (see all 8)1002-84-2--
    Stearic acid1-Heptadecanecarboxylate (see all 12)57-11-4--
    Tridecanoic acid(S)-2-Aminotridecanoate (see all 12)638-53-9--

    Search CenterWatch for drugs/clinical trials and news about CES3 / EST3

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CES3 gene (4 alternative transcripts): 
    NM_001185176.1  NM_001185177.1  NM_024922.5  NM_012122.1  

    Unigene Cluster for CES3:

    Carboxylesterase 3
    Hs.268700  [show with all ESTs]
    Unigene Representative Sequence: NM_024922
    8 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000303334(uc002eqt.3 uc010cdz.3) ENST00000394037 ENST00000566453
    ENST00000566746 ENST00000568118 ENST00000570236 ENST00000564715 ENST00000543856(uc010viw.2)

    miRNA
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    QIAGEN Custom miScript Target Protector blocks miRNA-binding site of human, mouse, rat CES3
    2 QIAGEN miScript miRNA Assays for microRNAs that regulate CES3:
    hsa-miR-645 hsa-miR-3714
    SwitchGear 3'UTR luciferase reporter plasmidCES3 3' UTR sequence
    Inhib. RNA
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    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CES3
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CES3
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      QIAGEN QuantiTect SYBR Green Assays in human, mouse, rat CES3
      QIAGEN QuantiFast Probe-based Assays in human, mouse, rat CES3

    Additional mRNA sequence: 

    AK000105.1 AK025158.1 AK025171.1 AK025389.1 AY358609.1 BC053670.1 

    5 DOTS entries:

    DT.101980426  DT.75128855  DT.92029825  DT.40251358  DT.120704429 

    GeneLoc Exon Structure

    5/6 Alternative Splicing Database (ASD) splice patterns (SP) for CES3 (see all 6)    About this scheme

    ExUns: 1a · 1b · 1c ^ 2 ^ 3a · 3b · 3c ^ 4a · 4b ^ 5 ^ 6 ^ 7a · 7b ^ 8 ^ 9 ^ 10 ^ 11a · 11b ^ 12 ^ 13a · 13b ^ 14a · 14b · 14c
    SP1:                                            -                                         -                             -                           
    SP2:                                            -                                         -                                                         
    SP3:                                -     -                                               -                                                         
    SP4:                                                                                      -     -     -     -                                       
    SP5:                                                                                                                                                


    ECgene alternative splicing isoforms for CES3

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CES3 expression in normal human tissues (normalized intensities)      CES3 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: CCTGACCCTC
    CES3 Expression
    About this image


    CES3 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/8 selected tissues (see all 8) fully expand
     
     Lung (Respiratory System)    fully expand to see all 4 entries
             Stem Bronchi
             visceral organ/lung/right lung   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             sigmoid colon mucosa   
     
     Pancreas (Endocrine System)    fully expand to see all 2 entries
             Duct Cells Pancreatic Ducts
             visceral organ/gut/foregut-midgut junction   
     
     Liver (Hepatobiliary System)    fully expand to see all 2 entries
             Mature Mesothelial Cells Hepatic Mesenchyme
             Liver Lobule
     
     Nose (Sensory Organs)    fully expand to see all 2 entries
             sensory organ/nose/nasal cavity   

    See CES3 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CES3

    SOURCE GeneReport for Unigene cluster: Hs.268700

    UniProtKB/Swiss-Prot: EST3_HUMAN, Q6UWW8
    Tissue specificity: Expressed in liver, colon and small intestine

        SABiosciences Expression via Pathway-Focused PCR Arrays including CES3: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Drug Metabolism in human mouse rat

    Primer
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    In Situ
    Assay Products:
     

     
    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CES3

    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CES3 gene from 4/6 species (see all 6)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ces1d5
    Ces3b1
    carboxylesterase 1D5
    carboxylesterase 3B1
    74.81(n)1
    66.55(a)1
      8 (45.05 cM)5
    139091  NM_144511.21  NP_653094.21 
     931660685 
    zebrafish
    (Danio rerio)
    Actinopterygii ces26
    ces36
    (see all 3)
    carboxylesterase 3
    (see all 3)
    40(a)
    40(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    18(17067638-17074777)
    18(17077342-17085474)
    fruit fly
    (Drosophila melanogaster)
    Insecta CG84243 carboxylesterase 42(a)
    (best of 23)
      52E5   --
    worm
    (Caenorhabditis elegans)
    Secernentea F15A8.63 esterase 45(a)
    (best of 23)
      X(4466430-4469785)   --


    ENSEMBL Gene Tree for CES3 (if available)
    TreeFam Gene Tree for CES3 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CES3 gene
    NLGN12  CES22  ACHE2  CES4A2  NLGN4X2  NLGN4Y2  NLGN32  NLGN22  
    CES12  CEL2  CES5A2  BCHE2  
    16 SIMAP similar genes for CES3 using alignment to 3 protein entries:     EST3_HUMAN (see all proteins):
    NLGN2    CES1P1    CES5A    CES1    CES2    CES hBr2
    CES8    TG    CES4A    DKFZp686F02202    ACHE    NLGN3
    CEL    BCHE    NLGN1    nlgn1

    CES3 for paralogs           About GeneDecksing



    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/419 SNPs in CES3 are shown (see all 419)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0607054
    ----see VAR_0607052 A V mis40--------
    rs716478731,2
    C,F--66993252(+) GCAAGT/CGTAAA 2 -- us2k16Minor allele frequency- C:0.03NS EA 274
    rs1837143341,2
    --66993286(+) GTGCCA/GACCCT 2 -- us2k10--------
    rs1888181821,2
    --66993353(+) TGCTGA/GCCTGT 2 -- us2k10--------
    rs1451247001,2
    --66993510(+) GTGGGC/TGGAGA 2 -- us2k10--------
    rs2017048581,2
    --66993748(+) ATGAA-/TTTTTT 2 -- us2k10--------
    rs1917645151,2
    --66993879(+) TGGCAC/GTAGTT 2 -- us2k10--------
    rs1491060231,2
    --66993976(+) GTGTTC/TAGGCA 2 -- us2k10--------
    rs1845406171,2
    --66993991(+) CCTCAC/TTCTGT 2 -- us2k10--------
    rs1888994521,2
    --66994053(+) CCAGCC/TATGTT 2 -- us2k10--------

    HapMap Linkage Disequilibrium report for CES3 (66995132 - 67009052 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CES3:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv906791CNV Loss21882294
    nsv906792CNV Loss21882294
    dgv2885n71CNV Loss21882294
    nsv827706CNV Loss20364138

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    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605279    OMIM disorders: --

    4 diseases for CES3:    About MalaCards
    dental pulp necrosis    lymph node tuberculosis    tuberculosis    alcoholism

    1 disease from the University of Copenhagen DISEASES database for CES3:
    Dental pulp necrosis

    CES3 for disorders           About GeneDecksing

    Human Genome Epidemiology (HuGE) Navigator: CES3 (1 document)

    Export disorders for CES3 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CES3 gene, integrated from 9 sources (see all 23):
    (articles sorted by number of sources associating them with CES3)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Hydrolysis of irinotecan and its oxidative metabolites, 7-ethyl-10- [4-N-(5-aminopentanoic acid)-1-piperidino] carbonyloxycamptothecin and 7-ethyl-10-[4-(1-piperidino)-1-amino]-carbonyloxycamptothecin, by human carboxylesterases CES1A1, CES2, and a newly expressed carboxylesterase isoenzyme, CES3. (PubMed id 15100172)1, 2, 3, 9 Sanghani S.P....Bosron W.F. (2004)
    2. Carboxylesterases expressed in human colon tumor tissue and their role in CPT-11 hydrolysis. (PubMed id 14581373)1, 2, 3, 9 Sanghani S.P.... Bosron W.F. (2003)
    3. Recommended nomenclature for five mammalian carboxyle sterase gene families: human, mouse, and rat genes and proteins. (PubMed id 20931200)1, 3 Holmes R.S....Maltais L.J. (2010)
    4. Complete sequencing and characterization of 21,243 full-length human cDNAs. (PubMed id 14702039)1, 2 Ota T.... Sugano S. (2004)
    5. The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment. (PubMed id 12975309)1, 2 Clark H.F.... Gray A.M. (2003)
    6. Human carboxylesterases: an update on CES1, CES2 and CES3. (PubMed id 19508181)1, 9 Sanghani S.P....Bosron W.F. (2009)
    7. Hydrolysis of capecitabine to 5'-deoxy-5-fluorocytidine by human carboxylesterases and inhibition by loperamide. (PubMed id 15687373)2, 9 Quinney S.K.... Bosron W.F. (2005)
    8. Mammalian carboxylesterase 3: comparative genomics an d proteomics. (PubMed id 20422440)1, 9 Holmes R.S....VandeBerg J.L. (2010)
    9. Identification of a novel intracellular cholesteryl es ter hydrolase (carboxylesterase 3) in human macrophages: compensatory increase i n its expression after carboxylesterase 1 silencing. (PubMed id 22700792)1 Zhao B....Ghosh S. (2012)
    10. Evaluation of candidate genes for cholinesterase acti vity in farmworkers exposed to organophosphorus pesticides: association of sing le nucleotide polymorphisms in BCHE. (PubMed id 20529763)1 Howard T.D....Arcury T.A. (2010)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
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    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 23491 HGNC: 1865 Ensembl:ENSG00000172828 euGenes: HUgn23491 ECgene: CES3
    H-InvDB: CES3

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CES3 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ces3/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CES3 gene:
    Search GeneIP for patents involving CES3

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    GeneCards Homepage - Last full update: 23 Oct 2013 - Incrementals: 3 Nov 2013 , 7 Nov 2013 , 23 Jan 2014

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