Aliases for CES2 Gene
Aliases for CES2 Gene
External Ids for CES2 Gene
- HGNC: 1864
- Entrez Gene: 8824
- Ensembl: ENSG00000172831
- OMIM: 605278
- UniProtKB: O00748
Previous GeneCards Identifiers for CES2 Gene
- GC16P057662
- GC16P067346
- GC16P066703
- GC16P066744
- GC16P065525
- GC16P066969
- GC16P052842
Summaries for CES2 Gene
-
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]
GeneCards Summary for CES2 Gene
CES2 (Carboxylesterase 2) is a Protein Coding gene. Diseases associated with CES2 include Fiedler's Myocarditis and Western Equine Encephalitis. Among its related pathways are the visual cycle I (vertebrates) and Phase I biotransformations, non P450. GO annotations related to this gene include hydrolase activity and methylumbelliferyl-acetate deacetylase activity. An important paralog of this gene is CES3.
UniProtKB/Swiss-Prot for CES2 Gene
-
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.
No data available for CIViC summary , Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CES2 Gene
Genomics for CES2 Gene
Regulatory Elements for CES2 Gene
Enhancers for CES2 Gene
- Elite enhancer and/or Elite enhancer-gene association
Download GeneHancer data dump
Enhancers around CES2 on UCSC Golden Path with GeneCards custom track
- Transcription factor binding sites by QIAGEN in the CES2 gene promoter:
Regulatory Element Products
Genomic Location for CES2 Gene
- Chromosome:
- 16
- Start:
- 66,934,444 bp from pter
- End:
- 66,945,096 bp from pter
- Size:
- 10,653 bases
- Orientation:
- Plus strand
Genomic View for CES2 Gene
Genes around CES2 on UCSC Golden Path with GeneCards custom track
- Cytogenetic band:
-
- 16q22.1 by Ensembl
- 16q22.1 by Entrez Gene
- 16q22.1 by HGNC
CES2 Gene in genomic location: bands according to
Ensembl, locations according to GeneLoc
(and/or Entrez Gene and/or Ensembl if different)
Genomic Neighborhood
• Exon Structure
• Gene Density
RefSeq DNA sequence for CES2 Gene
Proteins for CES2 Gene
-
Protein details for CES2 Gene (UniProtKB/Swiss-Prot)
- Protein Symbol:
- O00748-EST2_HUMAN
- Recommended name:
- Cocaine esterase
- Protein Accession:
- O00748
- A8K367
- Q16859
- Q5MAB8
- Q7Z366
- Q8IUP4
- Q8TCP8
Protein attributes for CES2 Gene
- Size:
- 559 amino acids
- Molecular mass:
- 61807 Da
- Quaternary structure:
-
- Monomer.
- SequenceCaution:
-
- Sequence=AAH32095.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAW29943.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD28531.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD98009.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};
Protein Expression for CES2 Gene
Selected DME Specific Peptides for CES2 Gene
- O00748:
-
- AALRWVQ
- AIMESGVA
- PLGPLRF
- GFFSTGD
- FLGIPFA
- YRLGVLGF
- PVMVWIHGG
Post-translational modifications for CES2 Gene
- Glycosylated.
- Glycosylation at Asn111 and posLast=276276
- Modification sites at PhosphoSitePlus
Other Protein References for CES2 Gene
- ENSEMBL proteins:
- REFSEQ proteins:
Antibody Products
- EMD Millipore Complete listing of Mono and Polychlonal Antibodies for CES2
- R&D Systems Antibodies for CES2 (Carboxylesterase 2/CES2)
- Novus Biologicals Antibodies for CES2
-
Abcam antibodies for CES2
- Invitrogen Antibodies for CES2
- GeneTex CES2 antibody for CES2
-
Santa Cruz Biotechnology (SCBT) Antibodies for CES2
Protein Products
- R&D Systems Proteins and Enzymes for CES2 (Carboxylesterase 2/CES2)
- Search Origene for MassSpec and Protein Over-expression Lysates for CES2
- Origene Custom Protein Services for CES2
- Sino Biological Recombinant Proteins for CES2
- Sino Biological Cell Lysates for CES2
- Search GeneTex for Proteins for CES2
-
Abcam proteins for CES2
Assay Products
Domains & Families for CES2 Gene
Gene Families for CES2 Gene
- HGNC:
Protein Domains for CES2 Gene
- InterPro:
- ProtoNet:
Suggested Antigen Peptide Sequences for CES2 Gene
- GenScript: Design optimal peptide antigens:
Graphical View of Domain Structure for InterPro Entry
O00748- Family:
-
- Belongs to the type-B carboxylesterase/lipase family.
Function for CES2 Gene
Molecular function for CES2 Gene
- UniProtKB/Swiss-Prot BiophysicochemicalProperties:
- Kinetic parameters: KM=0.39 mM for cocaine {ECO:0000269 PubMed:9169443}; KM=0.15 mM for 4-methylumbelliferyl acetate {ECO:0000269 PubMed:9169443}; KM=6.8 mM for heroin {ECO:0000269 PubMed:9169443}; KM=0.13 mM for 6-monoacetylmorphine {ECO:0000269 PubMed:9169443};
- UniProtKB/Swiss-Prot CatalyticActivity:
- Cocaine + H(2)O = ecgonine methyl ester + benzoate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- A carboxylic ester + H(2)O = an alcohol + a carboxylate.
- UniProtKB/Swiss-Prot CatalyticActivity:
- 4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate.
- UniProtKB/Swiss-Prot Function:
- Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.
Enzyme Numbers (IUBMB) for CES2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0016787 | hydrolase activity | IEA | -- |
| GO:0047374 | methylumbelliferyl-acetate deacetylase activity | IEA | -- |
| GO:0052689 | carboxylic ester hydrolase activity | IEA,TAS | -- |
Phenotypes for CES2 Gene
Animal Model Products
- Taconic Biosciences: Generate A Custom CRISPR Mouse Model For Your Study
- Cyagen custom Knockout/knockin (KOKI) mouse models for CES2
-
-
ViGene Biosciences lentiviral particle packaged cDNA for CES2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CES2 gene
- Search ViGene Biosciences for CES2
CRISPR Products
-
OriGene CRISPR knockouts for CES2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CES2
- GenScript: Design CRISPR guide RNA sequences for CES2
miRNA for CES2 Gene
- miRTarBase miRNAs that target CES2
-
- hsa-mir-1254 (MIRT035859)
- hsa-mir-18a-3p (MIRT040956)
- hsa-mir-106b-5p (MIRT044342)
- hsa-mir-92a-3p (MIRT049577)
- hsa-mir-3915 (MIRT458723)
- hsa-mir-7847-3p (MIRT458724)
- hsa-mir-6880-5p (MIRT458725)
- hsa-mir-4710 (MIRT458726)
- hsa-mir-7106-5p (MIRT458727)
- hsa-mir-6878-5p (MIRT458728)
- hsa-mir-4763-3p (MIRT458729)
- hsa-mir-1207-5p (MIRT458730)
- hsa-mir-6851-5p (MIRT458731)
- hsa-mir-3689d (MIRT458732)
- hsa-mir-765 (MIRT458733)
- hsa-mir-5703 (MIRT458734)
- hsa-mir-4516 (MIRT458735)
- hsa-mir-4434 (MIRT458736)
- hsa-mir-3202 (MIRT458737)
- hsa-mir-7854-3p (MIRT458738)
- hsa-mir-3928-3p (MIRT458739)
- hsa-mir-6770-5p (MIRT458740)
- hsa-mir-7515 (MIRT458741)
- hsa-mir-605-3p (MIRT458742)
- hsa-mir-6754-5p (MIRT458743)
- hsa-mir-4441 (MIRT458744)
- hsa-mir-4270 (MIRT458745)
- hsa-mir-6805-5p (MIRT458746)
- hsa-mir-4756-5p (MIRT458747)
- hsa-mir-4739 (MIRT458748)
- hsa-mir-6760-5p (MIRT458749)
- hsa-mir-1321 (MIRT458750)
- hsa-mir-6893-5p (MIRT458751)
- hsa-mir-940 (MIRT458752)
- hsa-mir-6808-5p (MIRT458753)
- hsa-mir-4779 (MIRT458754)
- hsa-mir-6876-5p (MIRT458755)
- hsa-mir-4476 (MIRT458756)
- hsa-mir-3714 (MIRT458757)
- hsa-mir-6869-5p (MIRT458758)
- hsa-mir-4279 (MIRT458759)
- hsa-mir-4465 (MIRT458760)
- hsa-mir-1200 (MIRT458761)
- hsa-mir-26b-5p (MIRT458762)
- hsa-mir-26a-5p (MIRT458763)
- hsa-mir-1297 (MIRT458764)
- hsa-mir-6829-3p (MIRT458765)
- hsa-mir-6791-3p (MIRT458766)
- hsa-mir-1976 (MIRT458767)
- hsa-mir-3653-5p (MIRT458768)
- hsa-mir-6747-3p (MIRT458769)
- hsa-mir-6727-3p (MIRT458770)
- hsa-mir-4722-3p (MIRT458771)
- hsa-mir-544b (MIRT458772)
- hsa-mir-4324 (MIRT458773)
- hsa-mir-660-3p (MIRT458774)
- hsa-mir-4726-3p (MIRT458775)
- hsa-mir-6764-5p (MIRT458776)
- hsa-mir-1915-3p (MIRT458777)
- hsa-mir-6840-3p (MIRT458778)
- hsa-mir-5697 (MIRT458779)
- hsa-mir-5571-5p (MIRT458780)
- hsa-mir-629-3p (MIRT714347)
- hsa-mir-1252-5p (MIRT714348)
miRNA Products
- Search ViGene Biosciences for CES2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CES2
- Browse OriGene Inhibitory RNA Products For CES2
-
ViGene Biosciences ready-to-package AAV shRNAs for CES2 gene
Clone Products
- Sino Biological Human cDNA Clone for CES2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CES2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CES2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Cell Line Products
-
Horizon Cell Lines for CES2
-
ViGene Biosciences adenoviral particle packaged cDNA for CES2 gene
-
ViGene Biosciences lentiviral particle packaged cDNA for CES2 gene
-
ViGene Biosciences ready-to-package AAV shRNAs for CES2 gene
Flow Cytometry Products
No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CES2 Gene
Localization for CES2 Gene
Subcellular locations from UniProtKB/Swiss-Prot for CES2 Gene
- Endoplasmic reticulum lumen.
| Compartment | Confidence |
|---|---|
| endoplasmic reticulum | 5 |
| plasma membrane | 3 |
| cytosol | 3 |
| golgi apparatus | 2 |
| nucleus | 1 |
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | TAS | 9144407 |
| GO:0005788 | endoplasmic reticulum lumen | IEA,TAS | -- |
Pathways & Interactions for CES2 Gene
| SuperPathway | Contained pathways | ||
|---|---|---|---|
| 1 | Irinotecan Pathway | ||
| 2 | Pyrimidine metabolism | ||
| 3 | Cytochrome P450 - arranged by substrate type | ||
| 4 | Porphyrin and chlorophyll metabolism | ||
| 5 | Metabolism |
.37
|
|
Pathways by source for CES2 Gene
6 BioSystems pathways for CES2 Gene
3 Reactome pathways for CES2 Gene
4 PharmGKB pathways for CES2 Gene
1 KEGG pathway for CES2 Gene
Interacting Proteins for CES2 Gene
| GO ID | Qualified GO term | Evidence | PubMed IDs |
|---|---|---|---|
| GO:0006805 | xenobiotic metabolic process | TAS | -- |
| GO:0009056 | catabolic process | TAS | 9169443 |
No data available for SIGNOR curated interactions for CES2 Gene
Drugs & Compounds for CES2 Gene
| Name | Status | Disease Links | Group | Role | Mechanism of Action | Clinical Trials |
|---|---|---|---|---|---|---|
| Irinotecan | Approved, Investigational | Pharma | Enzyme, substrate | Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors | 1123 | |
| Cocaine | Approved, Illicit | Pharma | 511 | |||
| Dabigatran etexilate | Approved | Pharma | Enzyme, substrate | 0 | ||
| Mycophenolate mofetil | Approved, Investigational | Pharma | Enzyme | IMPDH inhibitor | 952 | |
| Prasugrel | Approved | Pharma | Enzyme, substrate | ADP receptor inhibitor | 0 |
| Name | Synonyms | Role | CAS Number | PubChem IDs | PubMed IDs | |
|---|---|---|---|---|---|---|
| 4-Methylumbelliferyl acetate |
|
2747-05-9 | ||||
| 1,4'-Bipiperidine-1'-carboxylic acid |
|
|
|
|||
| 1-Pentanol |
|
71-41-0 |
|
|||
| 4-Amino-1-piperidinecarboxylic acid |
|
|
|
|||
| 4-methylumbelliferone |
|
|
Transcripts for CES2 Gene
mRNA/cDNA for CES2 Gene
- (4) REFSEQ mRNAs :
- (11) Additional mRNA sequences :
- (228) Selected AceView cDNA sequences:
- (12) Ensembl transcripts including schematic representations, and UCSC links where relevant :
CRISPR Products
-
OriGene CRISPR knockouts for CES2
-
Santa Cruz Biotechnology (SCBT) CRISPR for CES2
- GenScript: Design CRISPR guide RNA sequences for CES2
miRNA Products
- Search ViGene Biosciences for CES2
Inhibitory RNA Products
- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CES2
- Browse OriGene Inhibitory RNA Products For CES2
-
ViGene Biosciences ready-to-package AAV shRNAs for CES2 gene
Clone Products
- Sino Biological Human cDNA Clone for CES2
- Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat
- VectorBuilder custom plasmid, inducible vectors for CES2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CES2
-
VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Flow Cytometry Products
| ExUns: | 1a | · | 1b | ^ | 2 | ^ | 3a | · | 3b | · | 3c | · | 3d | · | 3e | ^ | 4a | · | 4b | · | 4c | ^ | 5 | ^ | 6 | ^ | 7a | · | 7b | ^ | 8a | · | 8b | ^ | 9a | · | 9b | ^ | 10 | ^ | 11 | ^ | 12a | · | 12b | ^ | 13a | · | 13b | · | 13c | ^ |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| SP1: | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||
| SP2: | - | - | ||||||||||||||||||||||||||||||||||||||||||||||||||
| SP3: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP4: | - | |||||||||||||||||||||||||||||||||||||||||||||||||||
| SP5: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP6: | - | - | - | - | - | - | ||||||||||||||||||||||||||||||||||||||||||||||
| SP7: | ||||||||||||||||||||||||||||||||||||||||||||||||||||
| SP8: | - | - | - | - | - | |||||||||||||||||||||||||||||||||||||||||||||||
| SP9: | - |
| ExUns: | 14 |
|---|---|
| SP1: | |
| SP2: | |
| SP3: | |
| SP4: | |
| SP5: | |
| SP6: | |
| SP7: | |
| SP8: | |
| SP9: |
Expression for CES2 Gene
mRNA differential expression in normal tissues according to GTEx for CES2 Gene
This gene is overexpressed in Liver (x5.4), Colon - Transverse (x5.2), Small Intestine - Terminal Ileum (x5.1), and Esophagus - Mucosa (x4.5).
This gene is overexpressed in Liver (20.9) and Stomach (11.4).
Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CES2 Gene
NURSA nuclear receptor signaling pathways regulating expression of CES2 Gene:
CES2SOURCE GeneReport for Unigene cluster for CES2 Gene:
Hs.282975mRNA Expression by UniProt/SwissProt for CES2 Gene:
O00748-EST2_HUMAN
Tissue specificity:
Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.
Evidence on tissue expression from TISSUES for CES2 Gene
- Intestine(4.9)
- Nervous system(4.9)
- Liver(4.7)
- Skin(4.3)
- Kidney(3.1)
- Lung(2.3)
Primer Products
-
OriGene qPCR primer pairs and template standards for CES2
-
OriGene qPCR primer pairs for CES2
No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery , Protein tissue co-expression partners and Phenotype-based relationships between genes and organs from Gene ORGANizer for CES2 Gene
Orthologs for CES2 Gene
This gene was present in the common ancestor of animals.
| Organism | Taxonomy | Gene | Similarity | Type | Details |
|---|---|---|---|---|---|
| chimpanzee (Pan troglodytes) |
Mammalia | CES2 34 35 |
|
||
| cow (Bos Taurus) |
Mammalia | CES2 34 35 |
|
||
| rat (Rattus norvegicus) |
Mammalia | Ces2h 34 |
|
||
| mouse (Mus musculus) |
Mammalia | Ces2h 34 16 35 |
|
||
| Ces2b 35 |
|
OneToMany | |||
| Ces2c 35 |
|
OneToMany | |||
| Ces2d-ps 35 |
|
OneToMany | |||
| Ces2e 35 |
|
OneToMany | |||
| Ces2g 35 |
|
OneToMany | |||
| Ces2a 35 |
|
OneToMany | |||
| Ces2f 35 |
|
OneToMany | |||
| dog (Canis familiaris) |
Mammalia | CES2 34 35 |
|
||
| oppossum (Monodelphis domestica) |
Mammalia | -- 35 |
|
OneToMany | |
| -- 35 |
|
OneToMany | |||
| -- 35 |
|
OneToMany | |||
| lizard (Anolis carolinensis) |
Reptilia | -- 35 |
|
ManyToMany | |
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| -- 35 |
|
ManyToMany | |||
| zebrafish (Danio rerio) |
Actinopterygii | ces3 35 |
|
ManyToMany | |
| ces2 35 |
|
ManyToMany | |||
| si:ch211-93f2.1 35 |
|
ManyToMany | |||
| fruit fly (Drosophila melanogaster) |
Insecta | alpha-Est4 36 |
|
|
|
| CG8424 36 |
|
|
|||
| alpha-Est10 36 |
|
|
|||
| alpha-Est2 36 |
|
|
|||
| alpha-Est7 36 |
|
|
|||
| Jhe 36 |
|
|
|||
| alpha-Est1 36 |
|
|
|||
| alpha-Est6 36 |
|
|
|||
| alpha-Est8 36 |
|
|
|||
| CG5397 36 |
|
|
|||
| CG6414 36 |
|
|
|||
| clt 36 |
|
|
|||
| Est-P 36 |
|
|
|||
| alpha-Est9 36 |
|
|
|||
| CG10175 36 |
|
|
|||
| CG3841 36 |
|
|
|||
| CG7529 36 |
|
|
|||
| CG9289 36 |
|
|
|||
| Est-6 36 |
|
|
|||
| CG12869 36 |
|
|
|||
| Glt 36 |
|
|
|||
| CG4382 36 |
|
|
|||
| CG9287 36 |
|
|
|||
| worm (Caenorhabditis elegans) |
Secernentea | T07H6.1a 36 |
|
|
|
| B0238.13 36 |
|
|
|||
| C52A10.2 36 |
|
|
|||
| F13H6.3 36 |
|
|
|||
| T02B5.3 36 |
|
|
|||
| R173.3 36 |
|
|
|||
| F13H6.4 36 |
|
|
|||
| Y71H2AM.13 36 |
|
|
|||
| B0238.7 36 |
|
|
|||
| K07C11.4 36 |
|
|
|||
| ges-1 36 |
|
|
|||
| T28C12.4a 36 |
|
|
|||
| T28C12.4b 36 |
|
|
|||
| F55D10.3 36 |
|
|
|||
| ZC376.2 36 |
|
|
|||
| T02B5.1 36 |
|
|
- Species where no ortholog for CES2 was found in the sources mined by GeneCards:
-
- A. gosspyii yeast (Ashbya gossypii)
- Actinobacteria (Mycobacterium tuberculosis)
- African clawed frog (Xenopus laevis)
- African malaria mosquito (Anopheles gambiae)
- Alicante grape (Vitis vinifera)
- alpha proteobacteria (Wolbachia pipientis)
- amoeba (Dictyostelium discoideum)
- Archea (Pyrococcus horikoshii)
- baker's yeast (Saccharomyces cerevisiae)
- barley (Hordeum vulgare)
- beta proteobacteria (Neisseria meningitidis)
- bread mold (Neurospora crassa)
- chicken (Gallus gallus)
- Chromalveolata (Phytophthora infestans)
- common water flea (Daphnia pulex)
- corn (Zea mays)
- E. coli (Escherichia coli)
- filamentous fungi (Aspergillus nidulans)
- Firmicute bacteria (Streptococcus pneumoniae)
- fission yeast (Schizosaccharomyces pombe)
- green algae (Chlamydomonas reinhardtii)
- honey bee (Apis mellifera)
- K. lactis yeast (Kluyveromyces lactis)
- loblloly pine (Pinus taeda)
- malaria parasite (Plasmodium falciparum)
- medicago trunc (Medicago Truncatula)
- moss (Physcomitrella patens)
- orangutan (Pongo pygmaeus)
- pig (Sus scrofa)
- platypus (Ornithorhynchus anatinus)
- rainbow trout (Oncorhynchus mykiss)
- rice (Oryza sativa)
- rice blast fungus (Magnaporthe grisea)
- schistosome parasite (Schistosoma mansoni)
- sea anemone (Nematostella vectensis)
- sea squirt (Ciona intestinalis)
- sea squirt (Ciona savignyi)
- sea urchin (Strongylocentrotus purpuratus)
- sorghum (Sorghum bicolor)
- soybean (Glycine max)
- stem rust fungus (Puccinia graminis)
- sugarcane (Saccharum officinarum)
- thale cress (Arabidopsis thaliana)
- tomato (Lycopersicon esculentum)
- toxoplasmosis (Toxoplasma gondii)
- Trichoplax (Trichoplax adhaerens)
- tropical clawed frog (Silurana tropicalis)
- wheat (Triticum aestivum)
Paralogs for CES2 Gene
Paralogs for CES2 Gene
(15) SIMAP similar genes for CES2 Gene using alignment to 7 proteins:
Pseudogenes.org Pseudogenes for CES2 Gene
Variants for CES2 Gene
| SNP ID | Clin | Chr 16 pos | Sequence Context | AA Info | Type |
|---|---|---|---|---|---|
| rs1000406021 | -- | 66,935,881(+) | TGGGC(-/TCCTAGAA)TCCTA | intron-variant, nc-transcript-variant, upstream-variant-2KB | |
| rs1000633117 | -- | 66,943,481(+) | TCACA(C/T)GATGG | intron-variant | |
| rs1000741847 | -- | 66,937,157(+) | GGGCA(A/G)CAGAT | intron-variant | |
| rs1000822938 | -- | 66,939,633(+) | AAGTG(C/T)CAAAG | intron-variant | |
| rs1000967376 | -- | 66,933,369(+) | TCCAA(A/C)CCCAT | intron-variant, upstream-variant-2KB |
Residual Variation Intolerance Score:
22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score:
1.30;
25.86% of all genes are more intolerant (likely to be disease-causing)
Relevant External Links for CES2 Gene
No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CES2 Gene
Disorders for CES2 Gene
| Disorder | Aliases | PubMed IDs |
|---|---|---|
| fiedler's myocarditis |
|
|
| western equine encephalitis |
|
|
| sparganosis |
|
|
Search CES2 in MalaCards
View complete list of genes associated with diseases
Relevant External Links for CES2
No data available for UniProtKB/Swiss-Prot and Genatlas for CES2 Gene
Publications for CES2 Gene
- Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver. (PMID: 9144407) Schwer H. … Schmitz G. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 22 64
- Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin. (PMID: 9169443) Pindel E.V. … Bosron W.F. (J. Biol. Chem. 1997) 2 3 4 22 64
- Haplotypes and a novel defective allele of CES2 found in a Japanese population. (PMID: 17640957) Kim S.R. … Sawada J. (Drug Metab. Dispos. 2007) 3 22 46 64
- Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38. (PMID: 15592324) Charasson V. … Robert J. (Clin. Pharmacol. Ther. 2004) 3 22 46 64
- Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2). (PMID: 15618752) Kim S.-R. … Sawada J. (Drug Metab. Pharmacokinet. 2003) 3 4 22 64
Products for CES2 Gene
- R&D Systems Antibodies for CES2 (Carboxylesterase 2/CES2)
- R&D Systems Proteins and Enzymes for CES2 (Carboxylesterase 2/CES2)
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- Search Origene for MassSpec and Protein Over-expression Lysates for CES2
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- Origene shRNA, siRNA, and RNAi products in human, mouse, rat for CES2
- Browse OriGene Inhibitory RNA Products For CES2
- OriGene qPCR primer pairs and template standards for CES2
- OriGene qPCR primer pairs for CES2
- OriGene CRISPR knockouts for CES2
- OriGene ORF clones in human for CES2
- Custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
- Browse OriGene miRNA Products For CES2
- GenScript: Next-day shipping cDNA ORF clone for CES2 in any vector
- GenScript Custom Purified and Recombinant Proteins Services for CES2
- GenScript Custom Assay Services for CES2
- GenScript Custom overexpressing Cell Line Services for CES2
- GenScript: Design CRISPR guide RNA sequences for CES2
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- CloneReady with Over 120,000 Genes
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- Gene Mutant Library, Variants up to 10^11
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- GenScript Custom Peptide Services for CES2
- Sino Biological Human cDNA Clone for CES2
- Sino Biological Recombinant Proteins for CES2
- Sino Biological Cell Lysates for CES2
- Sino Biological Antibodies
- Sino Biological ELISA Kits and Pair Sets
- Sino Biological Cell Lysates
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- Sino Biological CRO Services for Proteins, Antibodies and Genes
- Sino Biological Transfection Reagents
- Novus Biologicals Antibodies for CES2
- Novus Biologicals proteins and lysates for CES2
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- Abcam antibodies for CES2
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- ViGene Biosciences adenoviral particle packaged cDNA for CES2 gene
- ViGene Biosciences lentiviral particle packaged cDNA for CES2 gene
- ViGene Biosciences ready-to-package AAV shRNAs for CES2 gene
- Search ViGene Biosciences for CES2
- Santa Cruz Biotechnology (SCBT) Antibodies for CES2
- Search Santa Cruz Biotechnology (SCBT) for CES2 siRNA/shRNA
- Santa Cruz Biotechnology (SCBT) CRISPR for CES2
- Horizon Cell Lines for CES2
- Cyagen custom Knockout/knockin (KOKI) mouse models for CES2
- VectorBuilder custom plasmid, inducible vectors for CES2
- VectorBuilder custom lentivirus, adenovirus, AAV vector/virus packaging for CES2
- VectorBuilder Other custom vectors
- Mammalian expression: PiggyBac
- Mammalian Tet-on expression: plasmid
- Mammalian conditional (Cre-Lox): plasmid and PiggyBac
- Mammalian shRNA knockdown: lentiviral, adenoviral, AAV, and PiggyBac
- CRISPR: plasmid gRNA, lentiviral gRNA, and donor plasmid
- Bacterial expression: pET, pBAD, and pCS
- Yeast expression
Sources for CES2 Gene
- (1) GeneCards
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