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CES2 Gene

protein-coding   GIFtS: 62
GCID: GC16P066969

Carboxylesterase 2

(Previous names: carboxylesterase 2 (intestine, liver))
  See CES2-related disease
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
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Aliases
Carboxylesterase 21 2 3     Cocaine Esterase2
Carboxylesterase 2 (Intestine, Liver)1 2     iCE2
Methylumbelliferyl-Acetate Deacetylase 22 3     Intestinal Carboxylesterase; Liver Carboxylesterase-22
CE-22 3     EC 3.1.1.563
hCE-22 3     EC 3.1.1.843
EC 3.1.1.13 8     ICE3
CES2A12     EC 3.1.18
PCE-22     

External Ids:    HGNC: 18641   Entrez Gene: 88242   Ensembl: ENSG000001728317   OMIM: 6052785   UniProtKB: O007483   

Export aliases for CES2 gene to outside databases

Previous GC identifers: GC16P057662 GC16P067346 GC16P066703 GC16P066744 GC16P065525 GC16P052842


(According to Entrez Gene, GeneCards, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
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Entrez Gene summary for CES2 Gene:
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the
hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates
with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and
may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal
enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for
this gene.(provided by RefSeq, Oct 2010)

GeneCards Summary for CES2 Gene:
CES2 (carboxylesterase 2) is a protein-coding gene. Diseases associated with CES2 include north american indian childhood cirrhosis. GO annotations related to this gene include and methylumbelliferyl-acetate deacetylase activity. An important paralog of this gene is NLGN1.

UniProtKB/Swiss-Prot: EST2_HUMAN, O00748
Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows
high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and
6-monoacetylmorphine

Gene Wiki entry for CES2 (Carboxylesterase 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 75), Regulatory elements and Epigenetics data according to QIAGEN, and/or SwitchGear Genomics)
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RefSeq DNA sequence at NCBI GenBank:
NC_000016.9  NC_018927.2  NT_010498.16  
Regulatory elements:
   Regulatory transcription factor binding sites in the CES2 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCES2 promoter sequence
   Search Chromatin IP Primers for CES2

Epigenetics:
DNA Methylation CpG Assay Predesigned for Pyrosequencing in human, mouse, rat CES2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

CES2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CES2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P066969:  view genomic region     (about GC identifiers)

Start:
66,968,347 bp from pter      End:
66,978,999 bp from pter
Size:
10,653 bases      Orientation:
plus strand

(According to 1UniProtKB, HORDE, 2neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, Cloud-Clone Corp., and/or eBioscience,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, Cloud-Clone Corp., and/or eBioscience, Antibodies by EMD Millipore, R&D Systems, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, Cloud-Clone Corp, and/or others.)
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UniProtKB/Swiss-Prot: EST2_HUMAN, O00748 (See protein sequence)
Recommended Name: Cocaine esterase precursor  
Size: 559 amino acids; 61807 Da
Subunit: Monomer
Sequence caution: Sequence=AAH32095.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAW29943.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAD28531.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAD98009.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q16859 Q5MAB8 Q7Z366 Q8IUP4 Q8TCP8
Alternative splicing: 2 isoforms:  O00748-1   O00748-2   

Explore the universe of human proteins at neXtProt for CES2: NX_O00748

Explore proteomics data for CES2 at MOPED

Post-translational modifications: 

  • Glycosylated1
  • Glycosylation2 at Asn111, Asn276
  • Selected DME Specific Peptides for CES2 (O00748) (see all 7)
     PLGPLRF  GFFSTGD  AALRWVQ  FLGIPFA 


    See CES2 Protein Expression from SPIRE MOPED, PaxDB, and MaxQB

    REFSEQ proteins (2 alternative transcripts): 
    NP_003860.2  NP_932327.1  

    ENSEMBL proteins: 
     ENSP00000394452   ENSP00000463641   ENSP00000317842   ENSP00000456167   ENSP00000463166  
     ENSP00000457721   ENSP00000464620  

    CES2 Human Recombinant Protein Products:

    Browse Purified and Recombinant Proteins at EMD Millipore
    R&D Systems Recombinant & Natural Proteins for CES2 (Carboxylesterase 2/CES2)
    Browse recombinant and purified proteins available from Enzo Life Sciences
    OriGene Purified Proteins for CES2
    OriGene Protein Over-expression Lysate for CES2
    OriGene MassSpec for CES2
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    GenScript Custom Purified and Recombinant Proteins Services for CES2
    Novus Biologicals CES2 Proteins
    Novus Biologicals CES2 Lysates
    Sino Biological Recombinant Protein for CES2
    Sino Biological Cell Lysate for CES2
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CES2

     
    Search eBioscience for Proteins for CES2 

    CES2 Antibody Products:

    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
    R&D Systems Antibodies for CES2 (Carboxylesterase 2/CES2)
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    Novus Biologicals CES2 Antibodies
    Abcam antibodies for CES2
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    LSBio Antibodies in human, mouse, rat for CES2

    CES2 Assay Products:

    Browse Kits and Assays available from EMD Millipore
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    Browse Enzo Life Sciences for kits & assays
    Cloud-Clone Corp. ELISAs for CES2
    Cloud-Clone Corp. CLIAs for CES2
    Search eBioscience for ELISAs for CES2 


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
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    HGNC Gene Families:
    CES: Carboxylesterases

    3 InterPro protein domains:
     IPR019826 Carboxylesterase_B_AS
     IPR019819 Carboxylesterase_B_CS
     IPR002018 CarbesteraseB

    Graphical View of Domain Structure for InterPro Entry O00748

    ProtoNet protein and cluster: O00748

    UniProtKB/Swiss-Prot: EST2_HUMAN, O00748
    Similarity: Belongs to the type-B carboxylesterase/lipase family


    Find genes that share domains with CES2           About GenesLikeMe


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    transcription factor targeting from QIAGEN and/or HOMER, miRNA Gene Targets from miRTarBase, shRNA from OriGene, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, SwitchGear Genomics, Gene Editing from DNA2.0, Clones from OriGene, GenScript, Sino Biological, DNA2.0, Vector BioLabs and/or Addgene, Cell Lines from GenScript, ESI BIO, In Situ Hybridization Assays from Advanced Cell Diagnostics, Flow cytometry from eBioscience, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EST2_HUMAN, O00748
    Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows
    high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and
    6-monoacetylmorphine
    Catalytic activity: Cocaine + H(2)O = ecgonine methyl ester + benzoate
    Catalytic activity: A carboxylic ester + H(2)O = an alcohol + a carboxylate
    Catalytic activity: 4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate
    Biophysicochemical properties: Kinetic parameters: KM=0.39 mM for cocaine; KM=0.15 mM for 4-methylumbelliferyl
    acetate; KM=6.8 mM for heroin; KM=0.13 mM for 6-monoacetylmorphine;

         Enzyme Numbers (IUBMB): EC 3.1.1.11 2 EC 3.1.1.841 EC 3.1.12 EC 3.1.1.561

         Gene Ontology (GO): 3 molecular function terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0016787hydrolase activity ----
    GO:0047374methylumbelliferyl-acetate deacetylase activity IEA--
    GO:0052689carboxylic ester hydrolase activity TAS9169443
         
    Find genes that share ontologies with CES2           About GenesLikeMe


    Animal Models:
       inGenious Targeting Laboratory: Let us create your new Knockout/Knockin mouse model for CES2
       inGenious Targeting Laboratory: Contact us about creating complex and humanized mouse models for CES2

       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CES2
       genOway customized Knockin model: humanization, point mutation, expression monitoring, etc. for CES2

    miRNA
    Products:
        
    miRTarBase miRNAs that target CES2:
    hsa-mir-1254 (MIRT035859), hsa-mir-92a-3p (MIRT049577), hsa-mir-18a-3p (MIRT040956), hsa-mir-106b-5p (MIRT044342)

    Block miRNA regulation of human, mouse, rat CES2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CES2:
    hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidCES2 3' UTR sequence
    Inhib. RNA
    Products:
        
    OriGene RNAi products in human, mouse, rat for CES2
    Predesigned siRNA for gene silencing in human, mouse, rat CES2

    Gene Editing
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    DNA2.0 Custom Protein Engineering Service for CES2

    Clone
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    OriGene clones in human, mouse for CES2 (see all 12)
    OriGene ORF clones in mouse, rat for CES2
    OriGene custom cloning services - gene synthesis, subcloning, mutagenesis, variant library, vector shuttling
    GenScript: all cDNA clones in your preferred vector (see all 2): CES2 (NM_198061)
    Sino Biological Human cDNA Clone for CES2
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CES2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CES2

    Cell Line
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    Browse ESI BIO Cell Lines and PureStem Progenitors for CES2 
    In Situ Assay
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    Advanced Cell Diagnostics RNAscope RNA in situ hybridization assays for CES2


    (According to UniProtKB, COMPARTMENTS Subcellular localization database, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene.)
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    Subcellular locations from UniProtKB/Swiss-Prot
    EST2_HUMAN, O00748: Endoplasmic reticulum lumen (By similarity)
    Subcellular locations from COMPARTMENTS: 

    CompartmentConfidence
    endoplasmic reticulum4
    plasma membrane3
    cytosol1
    golgi apparatus1

    Gene Ontology (GO): 2 cellular component terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS9144407
    GO:0005788endoplasmic reticulum lumen IEA--

    Find genes that share ontologies with CES2           About GenesLikeMe


    (SuperPaths according to PathCards, Pathways according to R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to QIAGEN, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Apr 2014 via Entrez Gene).
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    SuperPaths for CES2 About   (see all 6)  
    See pathways by source

    SuperPathContained pathways About
    1Irinotecan Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacokinetics0.69
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics0.50
    Irinotecan Pathway0.69
    Irinotecan Pathway, Pharmacodynamics0.50
    2Pyrimidine metabolism
    Fluoropyrimidine Activity0.69
    Fluoropyrimidine Pathway, Pharmacokinetics0.69
    3the visual cycle I (vertebrates)
    retinol biosynthesis0.52
    4Glucuronidation
    Drug metabolism - other enzymes0.36
    5Phase I, non P450
    Phase I, non P450


    Find genes that share SuperPaths with CES2           About GenesLikeMe

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for CES2
        Fluoropyrimidine Activity
    Phase I, non P450
    Irinotecan Pathway
    E2F transcription factor network
    retinol biosynthesis


    4 PharmGKB Pathways for CES2
        Fluoropyrimidine Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacodynamics
    Irinotecan Pathway, Pharmacokinetics
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics

    1 Kegg Pathway  (Kegg details for CES2):
        Drug metabolism - other enzymes

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CES2: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Drug Metabolism in human mouse rat

    Interactions:

        GeneGlobe Interaction Network for CES2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 25)

    Selected Interacting proteins for CES2 (ENSP000003178424) via UniProtKB, MINT, STRING, and/or I2D (see all 26)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYP3A4ENSP000003379154STRING: ENSP00000337915
    CYP3A43ENSP000002223824STRING: ENSP00000222382
    CYP3A5ENSP000002229824STRING: ENSP00000222982
    GUSBENSP000003027284STRING: ENSP00000302728
    UGT1A1ENSP000003048454STRING: ENSP00000304845
    About this table

    Gene Ontology (GO): 2 biological process terms:    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0009056catabolic process TAS9169443

    Find genes that share ontologies with CES2           About GenesLikeMe



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience, ApexBio, HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB)
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    Browse Small Molecules at EMD Millipore
       Browse drugs & compounds from Enzo Life Sciences
      Browse compounds at ApexBio 

    Browse Tocris compounds for CES2 (EST2)

    Selected HMDB Compounds for CES2 (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Benzoic acidBenzenecarboxylate (see all 22)65-85-0--
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Ecgonine methyl esterMethyl ecgonine 7143-09-1--
    Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
    Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
    Myristic acid1-Tridecanecarboxylate (see all 15)544-63-8--
    Palmitic acidHexaectylic acid (see all 45)57-10-3--
    Pentadecanoic acidPentadecanoate (see all 8)1002-84-2--

    9 Novoseek inferred chemical compound relationships for CES2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4-methylumbelliferyl acetate 89.6 5 9169443 (2)
    sn 38 82.9 4 15592324 (1), 17640957 (1)
    irinotecan 80.9 18 12171903 (4), 15592324 (3), 17640957 (2), 17537833 (1) (see all 7)
    pyrethroids 66.8 11 16387282 (3), 17936933 (2), 16359636 (1)
    permethrin 66.4 7 18983829 (1), 16387282 (1)
    oseltamivir 54.4 1 17537833 (1), 18983829 (1)
    heroin 30.2 12 8930175 (3), 9169443 (2)
    serine 27.9 4 16858120 (1), 17640957 (1)
    cocaine 11.8 13 8930175 (3), 9169443 (2)



    Find genes that share compounds with CES2           About GenesLikeMe



    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN, SwitchGear Genomics,
    Tagged/untagged cDNA clones from OriGene, GenScript, DNA2.0, Vector BioLabs, and/or Addgene, Primers from OriGene, and/or QIAGEN, Flow cytometry from eBioscience )
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    REFSEQ mRNAs for CES2 gene (2 alternative transcripts): 
    NM_003869.5  NM_198061.2  

    Unigene Cluster for CES2:

    Carboxylesterase 2
    Hs.282975  [show with all ESTs]
    Unigene Representative Sequence: NR_036684
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000417689 ENST00000561697 ENST00000317091(uc002eqr.3 uc002eqq.3 uc002eqs.3)
    ENST00000568470 ENST00000566182 ENST00000570032 ENST00000566359 ENST00000561843
    ENST00000564420 ENST00000567128 ENST00000568347 ENST00000563988
    miRNA
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    Block miRNA regulation of human, mouse, rat CES2 using miScript Target Protectors
    1 qRT-PCR Assays for microRNA that regulate CES2:
    hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidCES2 3' UTR sequence
    Inhib. RNA
    Products:
         
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    Predesigned siRNA for gene silencing in human, mouse, rat CES2
    Clone
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    GenScript: all cDNA clones in your preferred vector (see all 2): CES2 (NM_198061)
    DNA2.0 Custom Codon Optimized Gene Synthesis Service for CES2
    Vector BioLabs ready-to-use adenovirus/AAV for human, mouse, rat CES2
    Primer
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    OriGene qPCR primer pairs and template standards for CES2
    OriGene qSTAR qPCR primer pairs in human, mouse for CES2
    Pre-validated RT2 qPCR Primer Assay in human, mouse / rat CES2
      QuantiTect SYBR Green Assays in human, mouse, rat CES2
      QuantiFast Probe-based Assays in human, mouse, rat CES2

    Additional mRNA sequence: 

    AK222724.1 AK290482.1 AL713761.1 BC032095.2 BC071874.1 BC098417.1 BX538086.1 D50579.1 
    NR_036684.1 U60553.1 Y09616.1 

    18 DOTS entries:

    DT.40253806  DT.100657424  DT.446048  DT.95090910  DT.97844372  DT.100019004  DT.92426599  DT.99966053 
    DT.100774506  DT.120704462  DT.75113902  DT.91662089  DT.95292699  DT.95304137  DT.100774505  DT.100807653 
    DT.120704408  DT.99930727 

    Selected AceView cDNA sequences (see all 228):

    BU677147 AA872847 CA427734 BU554150 AA365521 D50579 AW951458 CB117200 
    BQ184727 BE504597 AI342901 BU169071 AF147447 BM820193 BC032095 BG683103 
    CK904158 BQ639267 BM708843 BC071874 BQ953657 BI061986 BM672149 AJ712182 

    GeneLoc Exon Structure

    Selected Alternative Splicing Database (ASD) splice patterns (SP) for CES2 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^
    SP1:                                      -     -                                                                                                     -     -   
    SP2:                                                                                                                                                  -     -   
    SP3:                                      -     -                                                                                         -           -     -   
    SP4:                                                                                                                                      -                     
    SP5:                                                                                                                                                            

    ExUns: 14
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for CES2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MaxQB, plus additional links to SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from QIAGEN, Primers from OriGene, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
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    CES2 expression in normal human tissues (normalized intensities)
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGCCCATA
    CES2 Expression
    About this image


    CES2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database
     selected tissues (see all 10) fully expand
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex
     
     Ovary (Reproductive System)    fully expand to see all 2 entries
             Ovarian Mesenchymal Stroma Cells Ovary Interstitium
             Oviduct
     
     Liver (Hepatobiliary System)
             Hepatocytes Liver Lobule
     
     Bone (Muscoskeletal System)
             Bone Marrow
     
     Trophoblast (Extraembryonic Tissues)
             Trophoblast Cells Trophoblast
    CES2 Protein expression data from MOPED1, PaxDb2 and MaxQB3    About this image

    CES2 Protein Expression

    SOURCE GeneReport for Unigene cluster: Hs.282975

    UniProtKB/Swiss-Prot: EST2_HUMAN, O00748
    Tissue specificity: Preferentially expressed in intestine with moderate expression in liver. Within the intestine,
    highest expression is found in small intestine with lower expression in colon and rectum

        Pathway & Disease-focused RT2 Profiler PCR Arrays including CES2: 
              Drug Metabolism: Phase II Enzymes in human mouse rat
              Molecular Toxicology PathwayFinder 384HT in human mouse rat
              Drug Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
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    This gene was present in the common ancestor of chordates.

    Orthologs for CES2 gene from Selected species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ces2h1 , 5 carboxylesterase 2H1, 5 77.78(n)1
    72.94(a)1
      8 (53.04 cM)5
    4360591  NM_001272045.11  NP_001258974.11 
     1050008535 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 5)
    Uncharacterized protein
    (see all 5)
    50(a)
    49(a)
    (see all 5)
    many ↔ many
    many ↔ many
    (see all 5)
    GL343884.1(123099-138373)
    GL343520.1(257373-277392)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD101292.12   -- 70.39(n)    CD101292.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ces36
    ces26
    (see all 3)
    carboxylesterase 2 (intestine, liver)
    (see all 3)
    43(a)
    42(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    18(17077342-17085474) ENSDARG00000041595
    18(17067638-17074777) ENSDARG00000041569


    ENSEMBL Gene Tree for CES2 (if available)
    TreeFam Gene Tree for CES2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
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    Paralogs for CES2 gene
    NLGN12  ACHE2  CES4A2  NLGN4X2  NLGN4Y2  CES32  NLGN32  NLGN22  
    CES12  CEL2  CES5A2  BCHE2  
    15 SIMAP similar genes for CES2 using alignment to 7 protein entries:     EST2_HUMAN (see all proteins):
    CES1P1    CES5A    NLGN2    CES3    CES1    TG
    CES hBr2    CES8    CES4A    DKFZp686F02202    NLGN3    NLGN4X
    ACHE    BCHE    NLGN1

    Find genes that share paralogs with CES2           About GenesLikeMe


    2 Pseudogenes.org Pseudogenes for CES2
    PGOHUM00000262940 PGOHUM00000262345


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD), the Human Cytochrome P450 Allele Nomenclature Database, and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers, Cancer Mutation PCR Arrays and Assays, and Copy Number PCR Arrays from QIAGEN)
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    Selected SNPs for CES2 (see all 261)    About this table                                 

    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    rs1900677121,2
    --66970431(+) TCCAGA/CAACAA 3 -- int10--------
    rs115683141,2
    C,F,H--66970561(+) TCAGAA/TGCTGG 3 -- int118Minor allele frequency- T:0.03NS EA NA 1266
    rs753568271,2
    F--66970565(+) AAGCTG/AGGGGA 3 -- int11Minor allele frequency- A:0.03WA 118
    rs1388636851,2
    C--66970590(+) GGTCCG/TCTCAC 3 -- int10--------
    rs1821693301,2
    --66970887(+) AGAGAC/GCAGCT 3 -- int10--------
    rs47837451,2
    C,F,A--66970975(+) TACTCA/GGGAGG 3 -- int118Minor allele frequency- G:0.25NS NA WA CSA EA 1447
    rs1419882411,2
    C--66971069(+) ATGGCA/GACCTT 3 -- int10--------
    rs1872491321,2
    --66971226(+) CCCCAC/TGGCCC 3 -- int10--------
    rs115683111,2
    C,F,H--66971257(+) ACACCG/ACAGTA 3 -- int130Minor allele frequency- A:0.06NS EA NA WA 3072
    rs1446691331,2
    --66971331(+) ACAGTC/TATAAA 3 -- int10--------

    HapMap Linkage Disequilibrium report for CES2 (66968347 - 66978999 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CES2:    About this table    
    Variant IDTypeSubtypePubMed ID
    nsv906791CNV Loss21882294
    nsv906792CNV Loss21882294
    dgv2885n71CNV Loss21882294
    nsv827706CNV Loss20364138

    Human Gene Mutation Database (HGMD): CES2
    Site Specific Mutation Identification with PCR Assays
    SeqTarget long-range PCR primers for resequencing CES2
    DNA2.0 Custom Variant and Variant Library Synthesis for CES2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
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    OMIM gene information: 605278    OMIM disorders: --

    1 disease for CES2:    
    About MalaCards
    north american indian childhood cirrhosis


    Find genes that share disorders with CES2           About GenesLikeMe

    5 Novoseek inferred disease relationships for CES2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon carcinoma 28.8 1 11950785 (1)
    colorectal cancer 1.26 1 15592324 (1)
    adenocarcinoma 0 1 15967118 (1)
    tumors 0 1 12939466 (1)
    cancer 0 3 11716702 (1), 17640957 (1), 15967118 (1)

    Genetic Association Database (GAD): CES2
    Human Genome Epidemiology (HuGE) Navigator: CES2 (24 documents)

    Export disorders for CES2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
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    PubMed articles for CES2 gene, integrated from 10 sources (see all 85):
    (articles sorted by number of sources associating them with CES2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin. (PubMed id 9169443)1, 2, 3, 9 Pindel E.V.... Bosron W.F. (J. Biol. Chem. 1997)
    2. Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver. (PubMed id 9144407)1, 2, 3, 9 Schwer H.... Schmitz G. (Biochem. Biophys. Res. Commun. 1997)
    3. Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2). (PubMed id 15618752)1, 2, 9 Kim S.-R....Sawada J. (Drug Metab. Pharmacokinet. 2003)
    4. Haplotypes and a novel defective allele of CES2 found in a Japanese population. (PubMed id 17640957)1, 4, 9 Kim S.R....Sawada J. (Drug Metab. Dispos. 2007)
    5. Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38. (PubMed id 15592324)1, 4, 9 Charasson V....Robert J. (Clin. Pharmacol. Ther. 2004)
    6. Genetic variation in carboxylesterase genes and susceptibility to isoniazid-induced hepatotoxicity. (PubMed id 20195289)1, 4 Yamada S....Brooks-Wilson A. (Pharmacogenomics J. 2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (Mol. Med. 2010)
    8. Recommended nomenclature for five mammalian carboxylesterase gene families: human, mouse, and rat genes and proteins. (PubMed id 20931200)1, 3 Holmes R.S....Maltais L.J. (Mamm. Genome 2010)
    9. Variation at the NFATC2 locus increases the risk of thiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipril and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (Diabetes Care 2010)
    10. Fulfilling the promise of personalized medicine? Systematic review and field synopsis of pharmacogenetic studies. (PubMed id 19956635)1, 4 Holmes M.V....Casas J.P. (PLoS ONE 2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
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     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
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    Entrez Gene: 8824 HGNC: 1864 AceView: CES2 Ensembl:ENSG00000172831 euGenes: HUgn8824
    ECgene: CES2 Kegg: 8824 H-InvDB: CES2

    (According to HUGE)
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      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, UniProtKB/TrEMBL, and/or others, e.g. Wikipedia and GeneReviews, via UniProtKB/Swiss-Prot)
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    NameDescription
    PharmGKB entry for CES2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ces2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
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    Patent Information for CES2 gene:
    Search GeneIP for patents involving CES2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



    (Antibodies, recombinant proteins, and assays from EMD Millipore, R&D Systems, OriGene, QIAGEN, GenScript, Cell Signaling Technology, Novus Biologicals, Sino Biological, Enzo Life Sciences, Abcam, ProSpec, Cloud-Clone Corp., Thermo Fisher Scientific, LSBio, eBioscience, and/or others, Gene Editing from DNA2.0. Clones from OriGene, GenScript, Sino Biological, DNA2.0, SwitchGear Genomics, Vector BioLabs, Addgene, Cell lines from GenScript, and ESI BIO, Flow cytometery from eBioscience, PCR Arrays from QIAGEN, Drugs and/or compounds from EMD Millipore, Tocris Bioscience, Enzo Life Sciences, and/or ApexBio, In Situ Hybridization Assays from
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