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Category   Symbol Source: HGNC EntrezGene Ensembl GeneCards RNA genes CroW21
GIFtS

CES2 Gene

protein-coding   GIFtS: 63
GCID: GC16P066969

Carboxylesterase 2

(Previous names: carboxylesterase 2 (intestine, liver))
  See related diseases
at  

(According to 1HGNC, 2Entrez Gene,
3UniProtKB/Swiss-Prot, 4UniProtKB/TrEMBL, 5OMIM, 6GeneLoc, 7Ensembl, 8DME, 9miRBase, 10fRNAdb, 12H-InvDB, 13NCBI, 14NONCODE, and/or 15RNAdb)
About This Section

This gene clusters with an RNA gene
Subcategory (RNA class): lncRNA

Quality score for the ORGUL clustered with this gene is 3

Aliases
Carboxylesterase 21 2 3     Cocaine Esterase2
Carboxylesterase 2 (Intestine, Liver)1 2     iCE2
Methylumbelliferyl-Acetate Deacetylase 22 3     Intestinal Carboxylesterase; Liver Carboxylesterase-22
CE-22 3     EC 3.1.1.563
hCE-22 3     EC 3.1.1.843
EC 3.1.1.13 8     ICE3
CES2A12     EC 3.1.18
PCE-22     

External Ids:    HGNC: 18641   Entrez Gene: 88242   Ensembl: ENSG000001728317   OMIM: 6052785   UniProtKB: O007483   
ORGUL members:         
NONCODE14:n410182      

Export aliases for CES2 gene to outside databases

Previous GC identifers: GC16P057662 GC16P067346 GC16P066703 GC16P066744 GC16P065525 GC16P052842


(According to Entrez Gene, Tocris Bioscience, Wikipedia's Gene Wiki, PharmGKB,
UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL)
About This Section

Entrez Gene summary for CES2 Gene:
This gene encodes a member of the carboxylesterase large family. The family members are responsible for the
hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates
with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and
may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal
enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for
this gene.(provided by RefSeq, Oct 2010)

GeneCards Summary for CES2 Gene: 
CES2 (carboxylesterase 2) is a protein-coding gene, and is affiliated with the lncRNA class. Diseases associated with CES2 include north american indian childhood cirrhosis, and cystic echinococcosis, and among its related super-pathways are Irinotecan Pathway, Pharmacokinetics and Fluoropyrimidine Pathway, Pharmacokinetics. GO annotations related to this gene include carboxylesterase activity and methyl indole-3-acetate esterase activity. An important paralog of this gene is NLGN1.

UniProtKB/Swiss-Prot: EST2_HUMAN, O00748
Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows
high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and
6-monoacetylmorphine

Gene Wiki entry for CES2 (Carboxylesterase 2) Gene


(According to GeneLoc and/or HGNC, and/or
Entrez Gene (NCBI build 37),
and/or miRBase,
Genomic Views according to UCSC (hg19) and Ensembl (release 73), Regulatory elements and Epigenetics data according to QIAGEN, SABiosciences, and/or SwitchGear Genomics)
About This Section
RefSeq DNA sequence:
NC_000016.9  NC_018927.2  NT_010498.15  
Regulatory elements:
   SABiosciences Regulatory transcription factor binding sites in the CES2 gene promoter:
         AML1a   
         Other transcription factors

SwitchGear Promoter luciferase reporter plasmidCES2 promoter sequence
   Search SABiosciences Chromatin IP Primers for CES2

Epigenetics:
QIAGEN PyroMark CpG Assay predesigned Pyrosequencing DNA Methylation assays in human, mouse, rat CES2


Genomic Location:
Genomic View: UCSC Golden Path with GeneCards custom track

Entrez Gene cytogenetic band: 16q22.1   Ensembl cytogenetic band:  16q22.1   HGNC cytogenetic band: 16q22.1

CES2 Gene in genomic location: bands according to Ensembl, locations according to (and/or Entrez Gene and/or Ensembl if different)
CES2 gene location

GeneLoc information about chromosome 16         GeneLoc Exon Structure

GeneLoc location for GC16P066969:  view genomic region     (about GC identifiers)

Start:
66,968,347 bp from pter      End:
66,978,999 bp from pter
Size:
10,653 bases      Orientation:
plus strand

(According to UniProtKB, HORDE, neXtProt, Ensembl, and/or Reactome, Modification sites according to PhosphoSitePlus, Specific Peptides from DME, Protein expression images according to data from SPIRE 1MOPED, 2PaxDb, and 3MAXQB RefSeq according to NCBI, PDB rendering according to OCA and/or Proteopedia, Recombinant Proteins from EMD Millipore, R&D Systems, GenScript, Enzo Life Sciences, OriGene, Novus Biologicals, Sino Biological, ProSpec, and/or Cloud-Clone Corp.,
Biochemical Assays by EMD Millipore, R&D Systems, OriGene, GenScript, Cell Signaling Technology, Enzo Life Sciences, and/or Cloud-Clone Corp., Ontologies according to Gene Ontology Consortium 01 Oct 2013 and Entrez Gene, Antibodies by EMD Millipore, R&D Systems, GenScript, Cell Signaling Technology, OriGene, Novus Biologicals, Thermo Fisher Scientific, LSBio, Abcam, and/or Cloud-Clone Corp.)
About This Section

UniProtKB/Swiss-Prot: EST2_HUMAN, O00748 (See protein sequence)
Recommended Name: Cocaine esterase precursor  
Size: 559 amino acids; 61807 Da
Subunit: Monomer
Subcellular location: Endoplasmic reticulum lumen (By similarity)
Sequence caution: Sequence=AAH32095.1; Type=Erroneous initiation; Note=Translation N-terminally shortened;
Sequence=AAW29943.1; Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAD28531.1;
Type=Erroneous initiation; Note=Translation N-terminally shortened; Sequence=CAD98009.1; Type=Erroneous
initiation; Note=Translation N-terminally shortened;
Secondary accessions: Q16859 Q5MAB8 Q7Z366 Q8IUP4 Q8TCP8
Alternative splicing: 2 isoforms:  O00748-1   O00748-2   

Explore the universe of human proteins at neXtProt for CES2: NX_O00748

Explore proteomics data for CES2 at MOPED 

Post-translational modifications:

  • UniProtKB: Glycosylated
  • View modification sites using PhosphoSitePlus
  • View neXtProt modification sites for NX_O00748

  • 4/7 DME Specific Peptides for CES2 (O00748) (see all 7)
     PLGPLRF  GFFSTGD  AALRWVQ  FLGIPFA 

    CES2 Protein expression data from MOPED1, PaxDb2 and MAXQB3 :    About this image 

    CES2 Protein Expression
    REFSEQ proteins (2 alternative transcripts): 
    NP_003860.2  NP_932327.1  

    ENSEMBL proteins: 
     ENSP00000394452   ENSP00000463641   ENSP00000317842   ENSP00000456167   ENSP00000463166  
     ENSP00000457721   ENSP00000464620  

    Human Recombinant Protein Products for CES2: 
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    Novus Biologicals CES2 Proteins
    Novus Biologicals CES2 Lysates
    Sino Biological Recombinant Protein for CES2
    Sino Biological Cell Lysate for CES2 
    Browse ProSpec Recombinant Proteins
    Cloud-Clone Corp. Proteins for CES2 

    Gene Ontology (GO): 2 cellular component terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0005783endoplasmic reticulum TAS9144407
    GO:0005788endoplasmic reticulum lumen IEA--

    CES2 for ontologies           About GeneDecksing



    CES2 Antibody Products: 
    Browse EMD Millipore's Extensive Line of Mono- and Polyclonal Antibodies
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    Cloud-Clone Corp. CLIAs for CES2


    (According to HGNC, IUPHAR, InterPro, ProtoNet, UniProtKB, and/or BLOCKS, Sets of similar genes according to GeneDecks)
    About This Section
    HGNC Gene Families: 
    CES: Carboxylesterases

    3 InterPro protein domains:
     IPR019826 Carboxylesterase_B_AS
     IPR019819 Carboxylesterase_B_CS
     IPR002018 CarbesteraseB

    Graphical View of Domain Structure for InterPro Entry O00748

    ProtoNet protein and cluster: O00748

    UniProtKB/Swiss-Prot: EST2_HUMAN, O00748
    Similarity: Belongs to the type-B carboxylesterase/lipase family


    CES2 for domains           About GeneDecksing


    (According to 1UniProtKB, Genatlas, LifeMap Discovery™, IUBMB, and/or 2DME, Human phenotypes from GenomeRNAi, Animal models from MGI Mar 06 2013, inGenious Targeting Laboratory, genOway,
    bound targets from SABiosciences, miRNA Gene Targets from miRTarBase, shRNA from OriGene, RNAi from EMD Millipore, siRNAs from OriGene, QIAGEN, microRNA from QIAGEN, Gene Editing from DNA2.0, Sirion Biotech, Clones from EMD Millipore, OriGene, SwitchGear Genomics, GenScript, Sino Biological, DNA2.0, Vector BioLabs, and Sirion Biotech, Cell Lines from GenScript, LifeMap BioReagents, In Situ Hybridization Assays from Advanced Cell Diagnostics, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene.)
    About This Section

    Molecular Function:

         UniProtKB/Swiss-Prot Summary: EST2_HUMAN, O00748
    Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows
    high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and
    6-monoacetylmorphine
    Catalytic activity: Cocaine + H(2)O = ecgonine methyl ester + benzoate
    Catalytic activity: A carboxylic ester + H(2)O = an alcohol + a carboxylate
    Catalytic activity: 4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate
    Biophysicochemical properties: Kinetic parameters: KM=0.39 mM for cocaine; KM=0.15 mM for 4-methylumbelliferyl
    acetate; KM=6.8 mM for heroin; KM=0.13 mM for 6-monoacetylmorphine;

         Enzyme Numbers (IUBMB): EC 3.1.1.11 2 EC 3.1.1.841 EC 3.1.12 EC 3.1.1.561

         Gene Ontology (GO): 5/7 molecular function terms (GO ID links to tree view) (see all 7):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0004091carboxylesterase activity IBA--
    GO:0016787hydrolase activity ----
    GO:0047374methylumbelliferyl-acetate deacetylase activity IEA--
    GO:0050253retinyl-palmitate esterase activity ----
    GO:0080030methyl indole-3-acetate esterase activity ----
         
    CES2 for ontologies           About GeneDecksing


    Animal Models:
       inGenious Targeting Laboratory - Custom generated mouse model solutions for CES2 
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       genOway customized KO model: permanent, tissue-specific or time-controlled inactivation for CES2 
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    miRNA
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    1 QIAGEN miScript miRNA Assays for microRNA that regulate CES2:
    hsa-miR-1252
    SwitchGear 3'UTR luciferase reporter plasmidCES2 3' UTR sequence
    Inhib. RNA
    Products:
        
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    Clone
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    (Pathways according to EMD Millipore, R&D Systems, Cell Signaling Technology, KEGG, PharmGKB, BioSystems, Sino Biological, Reactome, Tocris Bioscience, GeneGo (Thomson Reuters), QIAGEN, and/or UniProtKB, Sets of similar genes according to GeneDecks, Interaction Networks according to SABiosciences, and/or STRING, Interactions according to 1UniProtKB, 2MINT, 3I2D, and/or 4STRING, with links to IntAct and Ensembl, Ontologies according to Gene Ontology Consortium 01 Oct 2013 via Entrez Gene).
    About This Section

    SuperPaths for CES2 About   (see all 6)                                                                                              See pathways by source

    SuperPathContained pathways About
    1Irinotecan Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacokinetics0.69
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics0.50
    Irinotecan Pathway0.69
    Irinotecan Pathway, Pharmacodynamics0.50
    2Fluoropyrimidine Activity
    Fluoropyrimidine Activity0.69
    Fluoropyrimidine Pathway, Pharmacokinetics0.69
    3the visual cycle I (vertebrates)
    retinol biosynthesis0.52
    4Glucuronidation
    Drug metabolism - other enzymes0.33
    5Phase I, non P450
    Phase I, non P450

    Pathways by source                                                                                                                                                                 See SuperPaths
    Show all pathways


    5 BioSystems Pathways for CES2
        Fluoropyrimidine Activity
    Phase I, non P450
    Irinotecan Pathway
    E2F transcription factor network
    retinol biosynthesis


    4 PharmGKB Pathways for CES2
        Fluoropyrimidine Pathway, Pharmacokinetics
    Irinotecan Pathway, Pharmacodynamics
    Irinotecan Pathway, Pharmacokinetics
    Mycophenolic acid Pathway, Pharmacokinetics/Pharmacodynamics

    1         Kegg Pathway  (Kegg details for CES2):
        Drug metabolism - other enzymes


    CES2 for pathways           About GeneDecksing

    Interactions:

        SABiosciences Gene Network CentralTM Interacting Genes and Proteins Network for CES2

    STRING Interaction Network Preview (showing 5 interactants - click image to see 24)

    5/24 Interacting proteins for CES2 (ENSP000003178424) via UniProtKB, MINT, STRING, and/or I2D (see all 24)
    InteractantInteraction Details
    GeneCardExternal ID(s)
    CYP3A4ENSP000003379154STRING: ENSP00000337915
    CYP3A43ENSP000002223824STRING: ENSP00000222382
    CYP3A5ENSP000002229824STRING: ENSP00000222982
    GUSBENSP000003027284STRING: ENSP00000302728
    UGT1A1ENSP000003048454STRING: ENSP00000304845
    About this table

    Gene Ontology (GO): 2 biological process terms (GO ID links to tree view):    About this table

    GO IDQualified GO termEvidencePubMed IDs
    GO:0008152metabolic process ----
    GO:0009056catabolic process TAS9169443

    CES2 for ontologies           About GeneDecksing



    (Chemical Compounds according to UniProtKB, Enzo Life Sciences, EMD Millipore, Tocris Bioscience HMDB, BitterDB, and/or Novoseek, Ligands according to IUPHAR, and Drugs according to DrugBank, Enzo Life Sciences, and/or PharmGKB, with drugs/clinical trials/news search links to CenterWatch)
    About This Section

    CES2 for compounds           About GeneDecksing

    Browse Small Molecules at EMD Millipore
    Browse drugs & compounds from Enzo Life Sciences

    Browse Tocris compounds for CES2 (EST2)

    10/13 HMDB Compounds for CES2 (see all 13)    About this table
    CompoundSynonyms CAS #PubMed Ids
    Arachidic acidArachate (see all 10)506-30-9--
    Arachidonic acid5,8,11,14-Eicosatetraenoic acid (see all 16)506-32-1--
    Benzoic acidBenzenecarboxylate (see all 22)65-85-0--
    Carbon dioxideCarbon oxide (see all 5)124-38-9--
    Ecgonine methyl esterMethyl ecgonine 7143-09-1--
    Heptadecanoic acidHeptadecanoate (see all 16)506-12-7--
    Heptadecanoyl CoAHeptadecanoyl coenzyme A (see all 19)3546-17-6--
    Myristic acid1-Tridecanecarboxylate (see all 15)544-63-8--
    Palmitic acidHexaectylic acid (see all 45)57-10-3--
    Pentadecanoic acidPentadecanoate (see all 8)1002-84-2--

    9 Novoseek inferred chemical compound relationships for CES2 gene    About this table
    Compound   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    4-methylumbelliferyl acetate 89.6 5 9169443 (2)
    sn 38 82.9 4 15592324 (1), 17640957 (1)
    irinotecan 80.9 18 12171903 (4), 15592324 (3), 17640957 (2), 17537833 (1) (see all 7)
    pyrethroids 66.8 11 16387282 (3), 17936933 (2), 16359636 (1)
    permethrin 66.4 7 18983829 (1), 16387282 (1)
    oseltamivir 54.4 1 17537833 (1), 18983829 (1)
    heroin 30.2 12 8930175 (3), 9169443 (2)
    serine 27.9 4 16858120 (1), 17640957 (1)
    cocaine 11.8 13 8930175 (3), 9169443 (2)

    Search CenterWatch for drugs/clinical trials and news about CES2 / EST2

    (Secondary structures according to fRNAdb,
    GenBank/EMBL/DDBJ Accessions according to
    Unigene (Build 236 Homo sapiens; Apr 25 2013) or GenBank,
    RefSeq according to Entrez Gene,
    DOTS (version 10), and/or AceView, transcript ids from Ensembl with links to UCSC,
    Conferences by KenesGroup, exon structure from GeneLoc, alternative splicing isoforms according to ASD and/or ECgene,
    RNAi Products from EMD Millipore,
    siRNAs from OriGene, QIAGEN, shRNA from OriGene, microRNA from QIAGEN,
    Tagged/untagged cDNA clones from OriGene, SwitchGear Genomics, GenScript, DNA2.0, Vector BioLabs, Sirion Biotech, Primers from OriGene, SABiosciences, and/or QIAGEN )
    About This Section

    REFSEQ mRNAs for CES2 gene (2 alternative transcripts): 
    NM_003869.5  NM_198061.2  

    Unigene Cluster for CES2:

    Carboxylesterase 2
    Hs.282975  [show with all ESTs]
    Unigene Representative Sequence: NR_036684
    12 Ensembl transcripts including schematic representations, and UCSC links where relevant:
    ENST00000417689 ENST00000561697 ENST00000317091(uc002eqr.3 uc002eqq.3 uc002eqs.3)
    ENST00000568470 ENST00000566182 ENST00000570032 ENST00000566359 ENST00000561843
    ENST00000564420 ENST00000567128 ENST00000568347 ENST00000563988
    miRNA
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    Additional mRNA sequence: 

    AK222724.1 AK290482.1 AL713761.1 BC032095.2 BC071874.1 BC098417.1 BX538086.1 D50579.1 
    NR_036684.1 U60553.1 Y09616.1 

    18 DOTS entries:

    DT.40253806  DT.100657424  DT.446048  DT.95090910  DT.97844372  DT.100019004  DT.92426599  DT.99966053 
    DT.100774506  DT.120704462  DT.75113902  DT.91662089  DT.95292699  DT.95304137  DT.100774505  DT.100807653 
    DT.120704408  DT.99930727 

    24/228 AceView cDNA sequences (see all 228):

    AA365521 AI076179 BQ184727 BI061986 AW951458 BU539622 AA586905 BQ005291 
    BQ649101 AA652652 BQ063048 BM820193 AI342901 NM_198061 AL713761 AF147447 
    AK095522 CN480493 AW769169 BG683103 CB850490 NM_003869 BC032095 BM755133 

    GeneLoc Exon Structure

    5/9 Alternative Splicing Database (ASD) splice patterns (SP) for CES2 (see all 9)    About this scheme

    ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^
    SP1:                                      -     -                                                                                                     -     -   
    SP2:                                                                                                                                                  -     -   
    SP3:                                      -     -                                                                                         -           -     -   
    SP4:                                                                                                                                      -                     
    SP5:                                                                                                                                                            

    ExUns: 14
    SP1:      
    SP2:      
    SP3:      
    SP4:      
    SP5:      


    ECgene alternative splicing isoforms for CES2

    (RNA expression data according to H-InvDB, NONCODE, miRBase, and RNAdb, Expression images according to data from BioGPS, Illumina Human BodyMap, and CGAP SAGE, Sets of similar genes according to GeneDecks, in vivo and in vitro expression data from LifeMap Discovery™, plus additional links to Genevestigator, and/or SOURCE, and/or BioGPS, and/or UniProtKB,
    PCR Arrays from SABiosciences, Primers from OriGene, SABiosciences, and/or QIAGEN, In Situ Hybridization Assays from Advanced Cell Diagnostics)
    About This Section

    CES2 expression in normal human tissues (normalized intensities)      CES2 embryonic expression: see
    See probesets specificity/sensitivity at GeneAnnot
    About this imageBioGPS <intensity>2/3
    CGAP TAG: ATGGCCCATA
    CES2 Expression
    About this image


    CES2 expression in embryonic tissues and stem cells    About this table
    Data from LifeMap, the Embryonic Development and Stem Cells Database 
     5/35 selected tissues (see all 35) fully expand
     
     Epithelium
             vagina ; squamous epithelial cells   
     
     Uterus
             uterus, post-menopause ; glandular cells   
     
     Testis (Reproductive System)    fully expand to see all 4 entries
             Leydig Cells Testis Interstitium
             seminal vesicle ; glandular cells   
     
     Colon (Gastrointestinal Tract)    fully expand to see all 4 entries
             colon ; peripheral nerve/ganglion   
     
     Brain (Nervous System)    fully expand to see all 4 entries
             Cerebral Cortex

    See CES2 Protein Expression from SPIRE MOPED and PaxDB
    Genevestigator expression for CES2

    SOURCE GeneReport for Unigene cluster: Hs.282975

    UniProtKB/Swiss-Prot: EST2_HUMAN, O00748
    Tissue specificity: Preferentially expressed in intestine with moderate expression in liver. Within the intestine,
    highest expression is found in small intestine with lower expression in colon and rectum

        SABiosciences Expression via Pathway-Focused PCR Arrays including CES2: 
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              Drug Metabolism in human mouse rat

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    (Orthologs according to 1,2HomoloGene (2older version, for species not in 1newer version), 3euGenes, 4SGD , 5MGI Mar 06 2013, with possible further links to Flybase and/or WormBase, and/or 6Ensembl pan taxonomic compara , Gene Trees according to Ensembl and TreeFam)
    About This Section

    This gene was present in the common ancestor of animals.

    Orthologs for CES2 gene from 6/11 species (see all 11)    About this table
    Organism Taxonomic
    classification
    Gene Description Human
    Similarity
    Orthology
    Type
    Details
    mouse
    (Mus musculus)
    Mammalia Ces2h1 , 5 carboxylesterase 2H1, 5 77.78(n)1
    72.94(a)1
      8 (53.04 cM)5
    4360591  XM_488149.11  XP_488149.11 
     1050008535 
    lizard
    (Anolis carolinensis)
    Reptilia --
    --
    (see all 5)
    --
    48(a)
    47(a)
    (see all 5)
    1 ↔ many
    1 ↔ many
    (see all 5)
    GL343884.1(123099-138373)
    GL343676.1(2729-12639)
    African clawed frog
    (Xenopus laevis)
    Amphibia CD101292.12   -- 70.39(n)    CD101292.1 
    zebrafish
    (Danio rerio)
    Actinopterygii ces26
    ces36
    (see all 3)
    carboxylesterase 3
    (see all 3)
    43(a)
    42(a)
    (see all 3)
    many ↔ many
    many ↔ many
    (see all 3)
    18(17067638-17074777)
    18(17077342-17085474)
    fruit fly
    (Drosophila melanogaster)
    Insecta alpha-Est43 carboxylesterase 40(a)
    (best of 23)
      3 84D9   --
    worm
    (Caenorhabditis elegans)
    Secernentea T07H6.1a3 esterase 39(a)
    (best of 16)
        --


    ENSEMBL Gene Tree for CES2 (if available)
    TreeFam Gene Tree for CES2 (if available)

    (Paralogs according to 1HomoloGene,
    2Ensembl, and 3SIMAP, Pseudogenes according to 4Pseudogene.org Build 68)
    About This Section
    Paralogs for CES2 gene
    NLGN12  ACHE2  CES4A2  NLGN4X2  NLGN4Y2  CES32  NLGN32  NLGN22  
    CES12  CEL2  CES5A2  BCHE2  
    15 SIMAP similar genes for CES2 using alignment to 7 protein entries:     EST2_HUMAN (see all proteins):
    CES1P1    CES5A    NLGN2    CES3    CES1    TG
    CES hBr2    CES8    CES4A    DKFZp686F02202    NLGN4X    ACHE
    NLGN3    BCHE    NLGN1

    CES2 for paralogs           About GeneDecksing


    2 Pseudogenes.org Pseudogenes for CES2
    PGOHUM00000262940 PGOHUM00000262345


    (SNPs/Variants according to the 1NCBI SNP Database, 2Ensembl, 3PupaSUITE, 4UniProtKB, and DNA2.0, Linkage Disequilibrium by HapMap, Structural Variations(CNVs/InDels/Inversions) from the Database of Genomic Variants, Mutations from the Human Gene Mutation Database (HGMD) and the Locus Specific Mutation Databases (LSDB), Blood group antigen gene mutations by BGMUT, Resequencing Primers from QIAGEN, Cancer Mutation PCR Arrays and Assays and Copy Number PCR Arrays from SABiosciences)
    About This Section

    10/261 SNPs in CES2 are shown (see all 261)    About this table     
    Genomic DataTranscription Related DataAllele Frequencies
    SNP IDValidClinical
    significance
    Chr 16 posSequence#AA
    Chg
    TypeMore#Allele
    freq
    PopTotal
    sample
    More
    ----------
    VAR_0183974
    ----see VAR_0183972 R H mis40--------
    VAR_0183964
    ----see VAR_0183962 R W mis40--------
    rs1900677121,2
    --66970431(+) TCCAGA/CAACAA 3 -- int10--------
    rs115683141,2
    C,F,H--66970561(+) TCAGAA/TGCTGG 3 -- int118Minor allele frequency- T:0.03NS EA NA 1266
    rs753568271,2
    F--66970565(+) AAGCTG/AGGGGA 3 -- int11Minor allele frequency- A:0.03WA 118
    rs1388636851,2
    C--66970590(+) GGTCCG/TCTCAC 3 -- int10--------
    rs1821693301,2
    --66970887(+) AGAGAC/GCAGCT 3 -- int10--------
    rs47837451,2
    C,F,A--66970975(+) TACTCA/GGGAGG 3 -- int118Minor allele frequency- G:0.25NS NA WA CSA EA 1447
    rs1419882411,2
    C--66971069(+) ATGGCA/GACCTT 3 -- int10--------
    rs1872491321,2
    --66971226(+) CCCCAC/TGGCCC 3 -- int10--------

    HapMap Linkage Disequilibrium report for CES2 (66968347 - 66978999 bp)

    Structural Variations
         Database of Genomic Variants (DGV) 4 variations for CES2:    About this table     
    Variant IDTypeSubtypePubMed ID
    nsv906791CNV Loss21882294
    nsv906792CNV Loss21882294
    dgv2885n71CNV Loss21882294
    nsv827706CNV Loss20364138


    Human Gene Mutation Database (HGMD): CES2
    SABiosciences Cancer Mutation PCR Assays
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    DNA2.0 Custom Variant and Variant Library Synthesis for CES2

    (in which this Gene is Involved, According to MalaCards, OMIM, UniProtKB, the University of Copenhagen DISEASES database, Conferences by KenesGroup, Novoseek, Genatlas, GeneTests, GAD, HuGE Navigator, and/or TGDB.)
    About This Section
    OMIM gene information: 605278    OMIM disorders: --

    20 diseases for CES2:    About MalaCards
    north american indian childhood cirrhosis    cystic echinococcosis    dental pulp necrosis    echinococcosis
    rubella    diffuse large b-cell lymphoma    barrett's esophagus    diarrhea
    b-cell lymphomas    neutropenia    multiple myeloma    cytochrome p450
    colorectal cancer    myeloma    osteosarcoma    hepatitis b
    alcoholism    adenocarcinoma    ovarian cancer    hepatitis


    CES2 for disorders           About GeneDecksing

    5 Novoseek inferred disease relationships for CES2 gene    About this table

    Disease   -log (P-Val)   Hits   PubMed IDs for Articles with Shared Sentences (# sentences)
    colon carcinoma 28.8 1 11950785 (1)
    colorectal cancer 1.26 1 15592324 (1)
    adenocarcinoma 0 1 15967118 (1)
    tumors 0 1 12939466 (1)
    cancer 0 3 11716702 (1), 17640957 (1), 15967118 (1)

    Genetic Association Database (GAD): CES2
    Human Genome Epidemiology (HuGE) Navigator: CES2 (24 documents)

    Export disorders for CES2 gene to outside databases

    (in PubMed. Associations of this gene to articles via 1Entrez Gene, 2UniProtKB/Swiss-Prot, 3HGNC, 4GAD, 5PharmGKB, 6HMDB, 7DrugBank, 8UniProtKB/TrEMBL, 9 Novoseek, and/or 10fRNAdb)
    About This Section

    PubMed articles for CES2 gene, integrated from 9 sources (see all 83):
    (articles sorted by number of sources associating them with CES2)
        Utopia: connect your pdf to the dynamic
    world of online information

    1. Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin. (PubMed id 9169443)1, 2, 3, 9 Pindel E.V.... Bosron W.F. (1997)
    2. Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver. (PubMed id 9144407)1, 2, 3, 9 Schwer H.... Schmitz G. (1997)
    3. Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2). (PubMed id 15618752)1, 2, 9 Kim S.-R....Sawada J. (2003)
    4. Haplotypes and a novel defective allele of CES2 found in a Japanese population. (PubMed id 17640957)1, 4, 9 Kim S.R....Sawada J. (2007)
    5. Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38. (PubMed id 15592324)1, 4, 9 Charasson V....Robert J. (2004)
    6. Genetic variation in carboxylesterase genes and susce ptibility to isoniazid-induced hepatotoxicity. (PubMed id 20195289)1, 4 Yamada S....Brooks-Wilson A. (2010)
    7. Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score. (PubMed id 20379614)1, 4 Rose J.E....Uhl G.R. (2010)
    8. Recommended nomenclature for five mammalian carboxyle sterase gene families: human, mouse, and rat genes and proteins. (PubMed id 20931200)1, 3 Holmes R.S....Maltais L.J. (2010)
    9. Variation at the NFATC2 locus increases the risk of t hiazolidinedione-induced edema in the Diabetes REduction Assessment with ramipr il and rosiglitazone Medication (DREAM) study. (PubMed id 20628086)1, 4 Bailey S.D....Anand S. (2010)
    10. Fulfilling the promise of personalized medicine? Syst ematic review and field synopsis of pharmacogenetic studies. (PubMed id 19956635)1, 4 Holmes M.V....Casas J.P. (2009)

    (in PubMed, OMIM, and NCBI Bookshelf)
    About This Section
     ANDOR
    Aliases
    Disorders
    Free Text  

      Query String
    PubMed
    OMIM
    NCBI Bookshelf
      (Note: In FireFox, select the above section and copy using Ctrl-C)

    (According to Entrez Gene, HGNC, AceView, euGenes, Ensembl, miRBase, ECgene, Kegg, and/or H-InvDB)
    About This Section
    Entrez Gene: 8824 HGNC: 1864 AceView: CES2 Ensembl:ENSG00000172831 euGenes: HUgn8824
    ECgene: CES2 Kegg: 8824 H-InvDB: CES2

    (According to HUGE)
    About This Section
      --

    (According to PharmGKB, ATLAS, HORDE, IMGT, LEIDEN, UniProtKB/Swiss-Prot, and/or UniProtKB/TrEMBL,
    Wikipedia and/or GeneReviews via UniProtKB/Swiss-Prot)
    About This Section
    NameDescription
    PharmGKB entry for CES2 Pharmacogenomics, SNPs, Pathways
    NIEHS-SNPshttp://egp.gs.washington.edu/data/ces2/

    (Patent information from GeneIP,
    Licensable technologies from WIS Yeda, Salk, Tufts,
    IP news from LifeMap Sciences, Inc.)
    About This Section
    Patent Information for CES2 gene:
    Search GeneIP for patents involving CES2

    GeneCards and IP:
    Japan Patent Office Licenses GeneCards     European Patent Office Licenses GeneCards     Improving the IP Search



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    About This Section

     
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