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Aliases for CES2 Gene

Aliases for CES2 Gene

  • Carboxylesterase 2 2 3 4 5
  • Methylumbelliferyl-Acetate Deacetylase 2 3 4
  • Carboxylesterase 2 (Intestine, Liver) 2 3
  • EC 3.1.1.1 4 61
  • HCE-2 3 4
  • CE-2 3 4
  • ICE 3 4
  • Intestinal Carboxylesterase; Liver Carboxylesterase-2 3
  • Cocaine Esterase 3
  • EC 3.1.1.84 4
  • EC 3.1.1.56 4
  • EC 3.1.1 61
  • CES2A1 3
  • PCE-2 3

External Ids for CES2 Gene

Previous GeneCards Identifiers for CES2 Gene

  • GC16P057662
  • GC16P067346
  • GC16P066703
  • GC16P066744
  • GC16P065525
  • GC16P066969
  • GC16P052842

Summaries for CES2 Gene

Entrez Gene Summary for CES2 Gene

  • This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]

GeneCards Summary for CES2 Gene

CES2 (Carboxylesterase 2) is a Protein Coding gene. Diseases associated with CES2 include Fiedler's Myocarditis and Sparganosis. Among its related pathways are Irinotecan Pathway, Pharmacokinetics and the visual cycle I (vertebrates). GO annotations related to this gene include hydrolase activity and methylumbelliferyl-acetate deacetylase activity. An important paralog of this gene is CES3.

UniProtKB/Swiss-Prot for CES2 Gene

  • Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.

Gene Wiki entry for CES2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CES2 Gene

Genomics for CES2 Gene

Regulatory Elements for CES2 Gene

Enhancers for CES2 Gene
GeneHancer Identifier Enhancer Score Enhancer Sources Gene-Enhancer Score TSS distance (kb) Number of Genes Away Size (kb) Transcription Factor Binding Sites within enhancer Gene Targets for Enhancer
- Elite enhancer/Elite enhancer-gene association

Enhancers around CES2 on UCSC Golden Path with GeneCards custom track

Promoters for CES2 Gene
Ensembl Regulatory Elements (ENSRs) TSS Distance (bp) Size (bp) Binding Sites for Transcription Factors within promoters

Transcription factor binding sites by QIAGEN in the CES2 gene promoter:

Genomic Location for CES2 Gene

Chromosome:
16
Start:
66,934,444 bp from pter
End:
66,945,096 bp from pter
Size:
10,653 bases
Orientation:
Plus strand

Genomic View for CES2 Gene

Genes around CES2 on UCSC Golden Path with GeneCards custom track

Cytogenetic band:
CES2 Gene in genomic location: bands according to Ensembl, locations according to GeneLoc (and/or Entrez Gene and/or Ensembl if different)
Genomic Location for CES2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CES2 Gene

Proteins for CES2 Gene

  • Protein details for CES2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00748-EST2_HUMAN
    Recommended name:
    Cocaine esterase
    Protein Accession:
    O00748
    Secondary Accessions:
    • A8K367
    • Q16859
    • Q5MAB8
    • Q7Z366
    • Q8IUP4
    • Q8TCP8

    Protein attributes for CES2 Gene

    Size:
    559 amino acids
    Molecular mass:
    61807 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAH32095.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAW29943.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD28531.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD98009.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CES2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CES2 Gene

Selected DME Specific Peptides for CES2 Gene

Post-translational modifications for CES2 Gene

Antibody Products

  • R&D Systems Antibodies for CES2 (Carboxylesterase 2/CES2)
  • Abcam antibodies for CES2

Domains & Families for CES2 Gene

Gene Families for CES2 Gene

Protein Domains for CES2 Gene

Suggested Antigen Peptide Sequences for CES2 Gene

Graphical View of Domain Structure for InterPro Entry

O00748

UniProtKB/Swiss-Prot:

EST2_HUMAN :
  • Belongs to the type-B carboxylesterase/lipase family.
Family:
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with CES2: view

Function for CES2 Gene

Molecular function for CES2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties:
Kinetic parameters: KM=0.39 mM for cocaine {ECO:0000269 PubMed:9169443}; KM=0.15 mM for 4-methylumbelliferyl acetate {ECO:0000269 PubMed:9169443}; KM=6.8 mM for heroin {ECO:0000269 PubMed:9169443}; KM=0.13 mM for 6-monoacetylmorphine {ECO:0000269 PubMed:9169443};
UniProtKB/Swiss-Prot CatalyticActivity:
Cocaine + H(2)O = ecgonine methyl ester + benzoate.
UniProtKB/Swiss-Prot CatalyticActivity:
A carboxylic ester + H(2)O = an alcohol + a carboxylate.
UniProtKB/Swiss-Prot CatalyticActivity:
4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate.
UniProtKB/Swiss-Prot Function:
Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.

Enzyme Numbers (IUBMB) for CES2 Gene

Gene Ontology (GO) - Molecular Function for CES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0047374 methylumbelliferyl-acetate deacetylase activity IEA --
GO:0052689 carboxylic ester hydrolase activity TAS --
genes like me logo Genes that share ontologies with CES2: view
genes like me logo Genes that share phenotypes with CES2: view

Animal Model Products

CRISPR Products

miRNA for CES2 Gene

miRTarBase miRNAs that target CES2

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

No data available for Human Phenotype Ontology , Animal Models , Transcription Factor Targets and HOMER Transcription for CES2 Gene

Localization for CES2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CES2 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CES2 Gene COMPARTMENTS Subcellular localization image for CES2 gene
Compartment Confidence
endoplasmic reticulum 5
cytosol 3
extracellular 3
plasma membrane 3
golgi apparatus 2
nucleus 1
vacuole 1

Gene Ontology (GO) - Cellular Components for CES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005783 endoplasmic reticulum TAS 9144407
GO:0005788 endoplasmic reticulum lumen TAS --
genes like me logo Genes that share ontologies with CES2: view

Pathways & Interactions for CES2 Gene

genes like me logo Genes that share pathways with CES2: view

Gene Ontology (GO) - Biological Process for CES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0006805 xenobiotic metabolic process TAS --
GO:0009056 catabolic process TAS 9169443
genes like me logo Genes that share ontologies with CES2: view

No data available for SIGNOR curated interactions for CES2 Gene

Drugs & Compounds for CES2 Gene

(22) Drugs for CES2 Gene - From: DrugBank, FDA Approved Drugs, HMDB, and Novoseek

Name Status Disease Links Group Role Mechanism of Action Clinical Trials
Irinotecan Approved, Investigational Pharma Enzyme, substrate Topoisomerase I inhibitor, TOPO I inhibitor, Topoisomerase 1 Inhibitors 1062
Cocaine Approved, Illicit Pharma 472
Dabigatran etexilate Approved Pharma Enzyme, substrate 0
Mycophenolate mofetil Approved, Investigational Pharma Enzyme IMPDH inhibitor 919
Prasugrel Approved Pharma Enzyme, substrate ADP receptor inhibitor 0

(13) Additional Compounds for CES2 Gene - From: HMDB and Novoseek

Name Synonyms Role CAS Number PubChem IDs PubMed IDs
4-Methylumbelliferyl acetate
  • 4-Methyl-7-acetyloxy coumarin
  • 4-Methylumbelliferyl acetate
  • 7-(Acetyloxy)-4-methyl-2-benzopyrone
  • 7-Acetoxy-4-methyl-2H-1-benzopyran-2-one
  • 7-Acetoxy-4-methylcoumarin
2747-05-9
1,4'-Bipiperidine-1'-carboxylic acid
1-Pentanol
  • 1-Pentanol
  • 1-Pentol
  • 1-Pentyl alcohol
  • Alcool amylique
  • Alcool amylique (french)
71-41-0
4-Amino-1-piperidinecarboxylic acid
4-methylumbelliferone
genes like me logo Genes that share compounds with CES2: view

Transcripts for CES2 Gene

Unigene Clusters for CES2 Gene

Carboxylesterase 2:
Representative Sequences:

CRISPR Products

Inhibitory RNA Products

Clone Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CES2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5:
SP6: - - - - - -
SP7:
SP8: - - - - -
SP9: -

ExUns: 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CES2 Gene

GeneLoc Exon Structure for
CES2
ECgene alternative splicing isoforms for
CES2

Expression for CES2 Gene

mRNA expression in normal human tissues for CES2 Gene

mRNA differential expression in normal tissues according to GTEx for CES2 Gene

This gene is overexpressed in Liver (x5.4), Colon - Transverse (x5.2), Small Intestine - Terminal Ileum (x5.1), and Esophagus - Mucosa (x4.5).

Protein differential expression in normal tissues from HIPED for CES2 Gene

This gene is overexpressed in Liver (20.9) and Stomach (11.4).

Integrated Proteomics: protein expression in normal tissues and cell lines from ProteomicsDB, PaxDb, MaxQB, and MOPED for CES2 Gene



NURSA nuclear receptor signaling pathways regulating expression of CES2 Gene:

CES2

SOURCE GeneReport for Unigene cluster for CES2 Gene:

Hs.282975

mRNA Expression by UniProt/SwissProt for CES2 Gene:

O00748-EST2_HUMAN
Tissue specificity: Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.
genes like me logo Genes that share expression patterns with CES2: view

Primer Products

No data available for mRNA expression in embryonic tissues and stem cells from LifeMap Discovery and Protein tissue co-expression partners for CES2 Gene

Orthologs for CES2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CES2 Gene

Organism Taxonomy Gene Similarity Type Details
cow
(Bos Taurus)
Mammalia CES2 34
  • 80.01 (n)
  • 72.94 (a)
CES2 35
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CES2 34
  • 71.89 (n)
  • 64.32 (a)
CES2 35
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ces2h 34
  • 77.78 (n)
  • 72.94 (a)
Ces2h 16
Ces2a 35
  • 67 (a)
OneToMany
Ces2b 35
  • 71 (a)
OneToMany
Ces2c 35
  • 71 (a)
OneToMany
Ces2d-ps 35
  • 71 (a)
OneToMany
Ces2e 35
  • 71 (a)
OneToMany
Ces2f 35
  • 64 (a)
OneToMany
Ces2g 35
  • 69 (a)
OneToMany
Ces2h 35
  • 73 (a)
OneToMany
chimpanzee
(Pan troglodytes)
Mammalia CES2 34
  • 97.81 (n)
  • 97.27 (a)
CES2 35
  • 97 (a)
OneToOne
rat
(Rattus norvegicus)
Mammalia Ces2h 34
  • 78.2 (n)
  • 73.48 (a)
oppossum
(Monodelphis domestica)
Mammalia -- 35
  • 52 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
-- 35
  • 58 (a)
OneToMany
lizard
(Anolis carolinensis)
Reptilia -- 35
  • 49 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
-- 35
  • 50 (a)
ManyToMany
-- 35
  • 48 (a)
ManyToMany
-- 35
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ces2 35
  • 42 (a)
ManyToMany
ces3 35
  • 43 (a)
ManyToMany
si:ch211-93f2.1 35
  • 15 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta alpha-Est1 36
  • 29 (a)
alpha-Est10 36
  • 30 (a)
alpha-Est2 36
  • 30 (a)
alpha-Est4 36
  • 40 (a)
alpha-Est6 36
  • 29 (a)
alpha-Est7 36
  • 30 (a)
alpha-Est8 36
  • 29 (a)
alpha-Est9 36
  • 28 (a)
CG10175 36
  • 28 (a)
CG12869 36
  • 27 (a)
CG3841 36
  • 28 (a)
CG4382 36
  • 26 (a)
CG5397 36
  • 29 (a)
CG6414 36
  • 29 (a)
CG7529 36
  • 28 (a)
CG8424 36
  • 31 (a)
CG9287 36
  • 26 (a)
CG9289 36
  • 28 (a)
clt 36
  • 29 (a)
Est-6 36
  • 28 (a)
Est-P 36
  • 29 (a)
Glt 36
  • 27 (a)
Jhe 36
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea B0238.13 36
  • 36 (a)
B0238.7 36
  • 28 (a)
C52A10.2 36
  • 31 (a)
F13H6.3 36
  • 31 (a)
F13H6.4 36
  • 29 (a)
F55D10.3 36
  • 26 (a)
ges-1 36
  • 27 (a)
K07C11.4 36
  • 28 (a)
R173.3 36
  • 30 (a)
T02B5.1 36
  • 25 (a)
T02B5.3 36
  • 31 (a)
T07H6.1a 36
  • 39 (a)
T28C12.4a 36
  • 27 (a)
T28C12.4b 36
  • 27 (a)
Y71H2AM.13 36
  • 29 (a)
ZC376.2 36
  • 26 (a)
Species where no ortholog for CES2 was found in the sources mined by GeneCards:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CES2 Gene

ENSEMBL:
Gene Tree for CES2 (if available)
TreeFam:
Gene Tree for CES2 (if available)

Paralogs for CES2 Gene

Paralogs for CES2 Gene

Pseudogenes.org Pseudogenes for CES2 Gene

genes like me logo Genes that share paralogs with CES2: view

Variants for CES2 Gene

Sequence variations from dbSNP and Humsavar for CES2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type
VAR_018396 -
VAR_018397 -
rs3848286 -- 66,943,531(-) CCCCA(C/T)GCACC intron-variant
rs8061994 -- 66,945,416(+) cacag(A/G)acgag downstream-variant-500B
rs8192924 -- 66,940,496(+) ACTAC(A/G)CTGGG nc-transcript-variant, reference, missense

Structural Variations from Database of Genomic Variants (DGV) for CES2 Gene

Variant ID Type Subtype PubMed ID
dgv526e214 CNV gain 21293372
nsv572904 CNV loss 21841781
nsv827706 CNV loss 20364138

Variation tolerance for CES2 Gene

Residual Variation Intolerance Score: 22.4% of all genes are more intolerant (likely to be disease-causing)
Gene Damage Index Score: 1.30; 25.86% of all genes are more intolerant (likely to be disease-causing)

Relevant External Links for CES2 Gene

Human Gene Mutation Database (HGMD)
CES2
SNPedia medical, phenotypic, and genealogical associations of SNPs for
CES2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CES2 Gene

Disorders for CES2 Gene

MalaCards: The human disease database

(5) MalaCards diseases for CES2 Gene - From: DISEASES

Disorder Aliases PubMed IDs
fiedler's myocarditis
  • fiedler myocarditis
sparganosis
  • infection by sparganum
western equine encephalitis
  • wee
cystic echinococcosis
  • echinococcus granulosus infection
dental pulp necrosis
  • necrosis of the pulp
- elite association - COSMIC cancer census association via MalaCards
Search CES2 in MalaCards View complete list of genes associated with diseases

Relevant External Links for CES2

Genetic Association Database (GAD)
CES2
Human Genome Epidemiology (HuGE) Navigator
CES2
Atlas of Genetics and Cytogenetics in Oncology and Haematology:
CES2
genes like me logo Genes that share disorders with CES2: view

No data available for UniProtKB/Swiss-Prot and Genatlas for CES2 Gene

Publications for CES2 Gene

  1. Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver. (PMID: 9144407) Schwer H. … Schmitz G. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 22 65
  2. Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin. (PMID: 9169443) Pindel E.V. … Bosron W.F. (J. Biol. Chem. 1997) 2 3 4 22 65
  3. Haplotypes and a novel defective allele of CES2 found in a Japanese population. (PMID: 17640957) Kim S.R. … Sawada J. (Drug Metab. Dispos. 2007) 3 22 46 65
  4. Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38. (PMID: 15592324) Charasson V. … Robert J. (Clin. Pharmacol. Ther. 2004) 3 22 46 65
  5. Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2). (PMID: 15618752) Kim S.-R. … Sawada J. (Drug Metab. Pharmacokinet. 2003) 3 4 22 65

Products for CES2 Gene

Sources for CES2 Gene

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