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Aliases for CES2 Gene

Aliases for CES2 Gene

  • Carboxylesterase 2 2 3 4
  • Methylumbelliferyl-Acetate Deacetylase 2 3 4
  • Carboxylesterase 2 (Intestine, Liver) 2 3
  • EC 3.1.1.1 4 63
  • HCE-2 3 4
  • CE-2 3 4
  • ICE 3 4
  • Intestinal Carboxylesterase; Liver Carboxylesterase-2 3
  • Cocaine Esterase 3
  • EC 3.1.1.84 4
  • EC 3.1.1.56 4
  • EC 3.1.1 63
  • CES2A1 3
  • PCE-2 3

External Ids for CES2 Gene

Previous GeneCards Identifiers for CES2 Gene

  • GC16P057662
  • GC16P067346
  • GC16P066703
  • GC16P066744
  • GC16P065525
  • GC16P066969
  • GC16P052842

Summaries for CES2 Gene

Entrez Gene Summary for CES2 Gene

  • This gene encodes a member of the carboxylesterase large family. The family members are responsible for the hydrolysis or transesterification of various xenobiotics, such as cocaine and heroin, and endogenous substrates with ester, thioester, or amide bonds. They may participate in fatty acyl and cholesterol ester metabolism, and may play a role in the blood-brain barrier system. The protein encoded by this gene is the major intestinal enzyme and functions in intestine drug clearance. Alternatively spliced transcript variants have been found for this gene.[provided by RefSeq, Oct 2010]

GeneCards Summary for CES2 Gene

CES2 (Carboxylesterase 2) is a Protein Coding gene. Diseases associated with CES2 include colorectal cancer. Among its related pathways are the visual cycle I (vertebrates) and E2F transcription factor network. GO annotations related to this gene include methylumbelliferyl-acetate deacetylase activity. An important paralog of this gene is CES3.

UniProtKB/Swiss-Prot for CES2 Gene

  • Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.

Gene Wiki entry for CES2 Gene

No data available for Tocris Summary , PharmGKB "VIP" Summary , fRNAdb sequence ontologies and piRNA Summary for CES2 Gene

Genomics for CES2 Gene

Regulatory Elements for CES2 Gene

Transcription factor binding sites by QIAGEN in the CES2 gene promoter:

Epigenetics Products

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat

Genomic Location for CES2 Gene

Start:
66,934,444 bp from pter
End:
66,945,096 bp from pter
Size:
10,653 bases
Orientation:
Plus strand

Genomic View for CES2 Gene

UCSC Golden Path with GeneCards custom track
Cytogenetic band:
Genomic Location for CES2 Gene
GeneLoc Logo Genomic Neighborhood Exon StructureGene Density

RefSeq DNA sequence for CES2 Gene

Proteins for CES2 Gene

  • Protein details for CES2 Gene (UniProtKB/Swiss-Prot)

    Protein Symbol:
    O00748-EST2_HUMAN
    Recommended name:
    Cocaine esterase
    Protein Accession:
    O00748
    Secondary Accessions:
    • A8K367
    • Q16859
    • Q5MAB8
    • Q7Z366
    • Q8IUP4
    • Q8TCP8

    Protein attributes for CES2 Gene

    Size:
    559 amino acids
    Molecular mass:
    61807 Da
    Quaternary structure:
    • Monomer.
    SequenceCaution:
    • Sequence=AAH32095.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=AAW29943.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD28531.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305}; Sequence=CAD98009.1; Type=Erroneous initiation; Note=Translation N-terminally shortened.; Evidence={ECO:0000305};

    Alternative splice isoforms for CES2 Gene

    UniProtKB/Swiss-Prot:

neXtProt entry for CES2 Gene

Proteomics data for CES2 Gene at MOPED

Selected DME Specific Peptides for CES2 Gene

Post-translational modifications for CES2 Gene

Antibody Products

  • R&D Systems Antibodies for CES2 (Carboxylesterase 2/CES2)

Domains for CES2 Gene

Gene Families for CES2 Gene

HGNC:
  • CES :Carboxylesterases

Protein Domains for CES2 Gene

Suggested Antigen Peptide Sequences for CES2 Gene

Graphical View of Domain Structure for InterPro Entry

O00748

UniProtKB/Swiss-Prot:

EST2_HUMAN :
  • O00748
Family:
  • Belongs to the type-B carboxylesterase/lipase family.
genes like me logo Genes that share domains with CES2: view

Function for CES2 Gene

Molecular function for CES2 Gene

UniProtKB/Swiss-Prot BiophysicochemicalProperties: Kinetic parameters: KM=0.39 mM for cocaine {ECO:0000269 PubMed:9169443}; KM=0.15 mM for 4-methylumbelliferyl acetate {ECO:0000269 PubMed:9169443}; KM=6.8 mM for heroin {ECO:0000269 PubMed:9169443}; KM=0.13 mM for 6-monoacetylmorphine {ECO:0000269 PubMed:9169443};
UniProtKB/Swiss-Prot CatalyticActivity: Cocaine + H(2)O = ecgonine methyl ester + benzoate.
UniProtKB/Swiss-Prot CatalyticActivity: A carboxylic ester + H(2)O = an alcohol + a carboxylate.
UniProtKB/Swiss-Prot CatalyticActivity: 4-methylumbelliferyl acetate + H(2)O = 4-methylumbelliferone + acetate.
UniProtKB/Swiss-Prot Function: Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. Shows high catalytic efficiency for hydrolysis of cocaine, 4-methylumbelliferyl acetate, heroin and 6-monoacetylmorphine.

Enzyme Numbers (IUBMB) for CES2 Gene

Gene Ontology (GO) - Molecular Function for CES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0016787 hydrolase activity --
GO:0047374 methylumbelliferyl-acetate deacetylase activity IEA --
GO:0052689 carboxylic ester hydrolase activity TAS 9169443
genes like me logo Genes that share ontologies with CES2: view

Animal Model Products

CRISPR Products

miRNA for CES2 Gene

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CES2

In Situ Assay Products

Flow Cytometry Products

No data available for Phenotypes , Animal Models , Transcription Factor Targeting and HOMER Transcription for CES2 Gene

Localization for CES2 Gene

Subcellular locations from UniProtKB/Swiss-Prot for CES2 Gene

Endoplasmic reticulum lumen.

Subcellular locations from

COMPARTMENTS
Jensen Localization Image for CES2 Gene COMPARTMENTS Subcellular localization image for CES2 gene
Compartment Confidence
endoplasmic reticulum 4
plasma membrane 3
cytosol 1
golgi apparatus 1

Gene Ontology (GO) - Cellular Components for CES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0005615 extracellular space IBA --
GO:0005783 endoplasmic reticulum TAS 9144407
GO:0005788 endoplasmic reticulum lumen IEA --
genes like me logo Genes that share ontologies with CES2: view

Pathways for CES2 Gene

genes like me logo Genes that share pathways with CES2: view

PCR Array Products

  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism in human,mouse,rat
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat
    • Molecular Toxicology PathwayFinder 384HT in human,mouse,rat

Interacting Proteins for CES2 Gene

Gene Ontology (GO) - Biological Process for CES2 Gene

GO ID Qualified GO term Evidence PubMed IDs
GO:0008152 metabolic process --
GO:0009056 catabolic process TAS 9169443
genes like me logo Genes that share ontologies with CES2: view

Compounds for CES2 Gene

(13) HMDB Compounds for CES2 Gene

Compound Synonyms Cas Number PubMed IDs
Arachidic acid
  • Arachate
506-30-9
Arachidonic acid
  • 5,8,11,14-Eicosatetraenoic acid
506-32-1
Benzoic acid
  • Benzenecarboxylate
65-85-0
Carbon dioxide
  • Carbon oxide
124-38-9
Ecgonine methyl ester
  • Methyl ecgonine
7143-09-1

(9) Novoseek inferred chemical compound relationships for CES2 Gene

Compound -log(P) Hits PubMed IDs
4-methylumbelliferyl acetate 89.6 2
sn 38 82.9 2
irinotecan 80.9 13
pyrethroids 66.8 6
permethrin 66.4 2
genes like me logo Genes that share compounds with CES2: view

Transcripts for CES2 Gene

Unigene Clusters for CES2 Gene

Carboxylesterase 2:
Representative Sequences:

CRISPR Products

miRNA Products

Inhibitory RNA Products

  • Predesigned siRNA for gene silencing in human,mouse,rat for CES2

Primer Products

Flow Cytometry Products

Alternative Splicing Database (ASD) splice patterns (SP) for CES2 Gene

ExUns: 1a · 1b ^ 2 ^ 3a · 3b · 3c · 3d · 3e ^ 4a · 4b · 4c ^ 5 ^ 6 ^ 7a · 7b ^ 8a · 8b ^ 9a · 9b ^ 10 ^ 11 ^ 12a · 12b ^ 13a · 13b · 13c ^
SP1: - - - -
SP2: - -
SP3: - - - - -
SP4: -
SP5:
SP6: - - - - - -
SP7:
SP8: - - - - -
SP9: -

ExUns: 14
SP1:
SP2:
SP3:
SP4:
SP5:
SP6:
SP7:
SP8:
SP9:

Relevant External Links for CES2 Gene

GeneLoc Exon Structure for
CES2
ECgene alternative splicing isoforms for
CES2

Expression for CES2 Gene

mRNA expression in normal human tissues for CES2 Gene

mRNA expression in embryonic tissues and stem cells from LifeMap Discovery

mRNA differential expression in normal tissues according to GTEx for CES2 Gene

This gene is overexpressed in Liver (5.4), Colon - Transverse (5.2), Small Intestine - Terminal Ileum (5.1), and Esophagus - Mucosa (4.5).

Integrated Proteomics: protein expression from ProteomicsDB, PaxDb, MOPED, and MaxQB for CES2 Gene

SOURCE GeneReport for Unigene cluster for CES2 Gene Hs.282975

mRNA Expression by UniProt/SwissProt for CES2 Gene

O00748-EST2_HUMAN
Tissue specificity: Preferentially expressed in intestine with moderate expression in liver. Within the intestine, highest expression is found in small intestine with lower expression in colon and rectum.
genes like me logo Genes that share expressions with CES2: view

In Situ Assay Products

Orthologs for CES2 Gene

This gene was present in the common ancestor of animals.

Orthologs for CES2 Gene

Organism Taxonomy Gene Similarity Type Details
chimpanzee
(Pan troglodytes)
Mammalia CES2 35
  • 97.81 (n)
  • 97.27 (a)
CES2 36
  • 97 (a)
OneToOne
cow
(Bos Taurus)
Mammalia CES2 35
  • 80.01 (n)
  • 72.94 (a)
CES2 36
  • 72 (a)
OneToOne
dog
(Canis familiaris)
Mammalia CES2 35
  • 71.89 (n)
  • 64.32 (a)
CES2 36
  • 75 (a)
OneToOne
mouse
(Mus musculus)
Mammalia Ces2a 36
  • 67 (a)
OneToMany
Ces2b 36
  • 71 (a)
OneToMany
Ces2c 36
  • 71 (a)
OneToMany
Ces2d-ps 36
  • 71 (a)
OneToMany
Ces2e 36
  • 71 (a)
OneToMany
Ces2f 36
  • 64 (a)
OneToMany
Ces2g 36
  • 69 (a)
OneToMany
Ces2h 35
  • 77.78 (n)
  • 72.94 (a)
Ces2h 16
Ces2h 36
  • 73 (a)
OneToMany
oppossum
(Monodelphis domestica)
Mammalia -- 36
  • 52 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
-- 36
  • 58 (a)
OneToMany
rat
(Rattus norvegicus)
Mammalia Ces2h 35
  • 78.2 (n)
  • 73.48 (a)
lizard
(Anolis carolinensis)
Reptilia -- 36
  • 49 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 50 (a)
ManyToMany
-- 36
  • 48 (a)
ManyToMany
-- 36
  • 42 (a)
ManyToMany
zebrafish
(Danio rerio)
Actinopterygii ces2 36
  • 42 (a)
ManyToMany
ces3 36
  • 43 (a)
ManyToMany
si:ch211-93f2.1 36
  • 15 (a)
ManyToMany
fruit fly
(Drosophila melanogaster)
Insecta CG7529 37
  • 28 (a)
alpha-Est2 37
  • 30 (a)
Glt 37
  • 27 (a)
Est-6 37
  • 28 (a)
CG6414 37
  • 29 (a)
alpha-Est8 37
  • 29 (a)
CG9289 37
  • 28 (a)
alpha-Est1 37
  • 29 (a)
CG9287 37
  • 26 (a)
CG12869 37
  • 27 (a)
CG3841 37
  • 28 (a)
CG4382 37
  • 26 (a)
alpha-Est6 37
  • 29 (a)
CG8424 37
  • 31 (a)
CG5397 37
  • 29 (a)
CG10175 37
  • 28 (a)
Est-P 37
  • 29 (a)
Jhe 37
  • 30 (a)
alpha-Est10 37
  • 30 (a)
alpha-Est4 37
  • 40 (a)
alpha-Est9 37
  • 28 (a)
clt 37
  • 29 (a)
alpha-Est7 37
  • 30 (a)
worm
(Caenorhabditis elegans)
Secernentea F55D10.3 37
  • 26 (a)
ZC376.2 37
  • 26 (a)
T02B5.3 37
  • 31 (a)
C52A10.2 37
  • 31 (a)
B0238.13 37
  • 36 (a)
T28C12.4a 37
  • 27 (a)
F13H6.4 37
  • 29 (a)
R173.3 37
  • 30 (a)
ges-1 37
  • 27 (a)
B0238.7 37
  • 28 (a)
T28C12.4b 37
  • 27 (a)
Y71H2AM.13 37
  • 29 (a)
K07C11.4 37
  • 28 (a)
T02B5.1 37
  • 25 (a)
T07H6.1a 37
  • 39 (a)
F13H6.3 37
  • 31 (a)
Species with no ortholog for CES2:
  • A. gosspyii yeast (Ashbya gossypii)
  • Actinobacteria (Mycobacterium tuberculosis)
  • African clawed frog (Xenopus laevis)
  • African malaria mosquito (Anopheles gambiae)
  • Alicante grape (Vitis vinifera)
  • alpha proteobacteria (Wolbachia pipientis)
  • amoeba (Dictyostelium discoideum)
  • Archea (Pyrococcus horikoshii)
  • baker's yeast (Saccharomyces cerevisiae)
  • barley (Hordeum vulgare)
  • beta proteobacteria (Neisseria meningitidis)
  • bread mold (Neurospora crassa)
  • chicken (Gallus gallus)
  • Chromalveolata (Phytophthora infestans)
  • common water flea (Daphnia pulex)
  • corn (Zea mays)
  • E. coli (Escherichia coli)
  • filamentous fungi (Aspergillus nidulans)
  • Firmicute bacteria (Streptococcus pneumoniae)
  • fission yeast (Schizosaccharomyces pombe)
  • green algae (Chlamydomonas reinhardtii)
  • honey bee (Apis mellifera)
  • K. lactis yeast (Kluyveromyces lactis)
  • loblloly pine (Pinus taeda)
  • malaria parasite (Plasmodium falciparum)
  • medicago trunc (Medicago Truncatula)
  • moss (Physcomitrella patens)
  • orangutan (Pongo pygmaeus)
  • pig (Sus scrofa)
  • platypus (Ornithorhynchus anatinus)
  • rainbow trout (Oncorhynchus mykiss)
  • rice (Oryza sativa)
  • rice blast fungus (Magnaporthe grisea)
  • schistosome parasite (Schistosoma mansoni)
  • sea anemone (Nematostella vectensis)
  • sea squirt (Ciona intestinalis)
  • sea squirt (Ciona savignyi)
  • sea urchin (Strongylocentrotus purpuratus)
  • sorghum (Sorghum bicolor)
  • soybean (Glycine max)
  • stem rust fungus (Puccinia graminis)
  • sugarcane (Saccharum officinarum)
  • thale cress (Arabidopsis thaliana)
  • tomato (Lycopersicon esculentum)
  • toxoplasmosis (Toxoplasma gondii)
  • Trichoplax (Trichoplax adhaerens)
  • tropical clawed frog (Silurana tropicalis)
  • wheat (Triticum aestivum)

Evolution for CES2 Gene

ENSEMBL:
Gene Tree for CES2 (if available)
TreeFam:
Gene Tree for CES2 (if available)

Paralogs for CES2 Gene

Paralogs for CES2 Gene

Pseudogenes.org Pseudogenes for CES2 Gene

genes like me logo Genes that share paralogs with CES2: view

Variants for CES2 Gene

Sequence variations from dbSNP and Humsavar for CES2 Gene

SNP ID Clin Chr 16 pos Sequence Context AA Info Type MAF
rs1058924 -- 66,944,408(+) GCAAA(A/G)AAAAC utr-variant-3-prime, nc-transcript-variant
rs1058925 -- 66,944,413(+) gaaaa(A/C)aaaat utr-variant-3-prime, nc-transcript-variant
rs2241409 -- 66,943,191(-) TTCTC(C/T)GCTTT intron-variant
rs2241410 -- 66,938,470(-) CTGGA(G/T)CCAAT intron-variant
rs2303218 -- 66,939,065(-) GTTAC(A/G)GGCCA intron-variant

Structural Variations from Database of Genomic Variants (DGV) for CES2 Gene

Variant ID Type Subtype PubMed ID
dgv2885n71 CNV Loss 21882294
nsv827706 CNV Loss 20364138
nsv906791 CNV Loss 21882294
nsv906792 CNV Loss 21882294

Relevant External Links for CES2 Gene

HapMap Linkage Disequilibrium report
CES2
Human Gene Mutation Database (HGMD)
CES2

No data available for Polymorphic Variants from UniProtKB/Swiss-Prot for CES2 Gene

Disorders for CES2 Gene

MalaCards: The human disease database

MalaCards: The human disease database. (1) Diseases for CES2 Gene including...

Search for CES2 Gene in MalaCards »

(5) Novoseek inferred disease relationships for CES2 Gene

Disease -log(P) Hits PubMed IDs
colon carcinoma 28.8 1
colorectal cancer 1.26 1
adenocarcinoma 0 1
tumors 0 1
cancer 0 3

Relevant External Links for CES2

Genetic Association Database (GAD)
CES2
Human Genome Epidemiology (HuGE) Navigator
CES2
genes like me logo Genes that share disorders with CES2: view

No data available for UniProtKB/Swiss-Prot for CES2 Gene

Publications for CES2 Gene

  1. Molecular cloning and characterization of a novel putative carboxylesterase, present in human intestine and liver. (PMID: 9144407) Schwer H. … Schmitz G. (Biochem. Biophys. Res. Commun. 1997) 2 3 4 23
  2. Purification and cloning of a broad substrate specificity human liver carboxylesterase that catalyzes the hydrolysis of cocaine and heroin. (PMID: 9169443) Pindel E.V. … Bosron W.F. (J. Biol. Chem. 1997) 2 3 4 23
  3. Pharmacogenetics of human carboxylesterase 2, an enzyme involved in the activation of irinotecan into SN-38. (PMID: 15592324) Charasson V. … Robert J. (Clin. Pharmacol. Ther. 2004) 3 23 48
  4. Twelve novel single nucleotide polymorphisms in the CES2 gene encoding human carboxylesterase 2 (hCE-2). (PMID: 15618752) Kim S.-R. … Sawada J. (Drug Metab. Pharmacokinet. 2003) 3 4 23
  5. Haplotypes and a novel defective allele of CES2 found in a Japanese population. (PMID: 17640957) Kim S.R. … Sawada J. (Drug Metab. Dispos. 2007) 3 23 48

Products for CES2 Gene

  • DNA Methylation CpG Assay Predesigned for Pyrosequencing in human,mouse,rat
  • Pathway & Disease-focused RT² Profiler PCR Arrays
    • Drug Metabolism in human,mouse,rat
    • Drug Metabolism: Phase II Enzymes in human,mouse,rat
    • Molecular Toxicology PathwayFinder 384HT in human,mouse,rat
  • QIAGEN qRT-PCR Assays for microRNAs that regulate CES2
  • QuantiTect SYBR Green Assays in human,mouse,rat
  • Pre-validated RT² qPCR Primer Assay in human,mouse,rat
  • QuantiFast Probe-based Assays in human,mouse,rat
  • Predesigned siRNA for gene silencing in human,mouse,rat for CES2
  • Block miRNA regulation of CES2 using miScript Target Protectors

Sources for CES2 Gene

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